Gene Symbol: DUOX2
Description: dual oxidase 2
Alias: LNOX2, NOXEF2, P138-TOX, TDH6, THOX2, dual oxidase 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, NADPH thyroid oxidase 2, dual oxidase-like domains 2, flavoprotein NADPH oxidase, large NOX 2, long NOX 2, nicotinamide adenine dinucleotide phosphate oxidase, p138 thyroid oxidase, thyroid oxidase 2
Species: human
Products:     DUOX2

Top Publications

  1. Forteza R, Salathe M, Miot F, Forteza R, Conner G. Regulated hydrogen peroxide production by Duox in human airway epithelial cells. Am J Respir Cell Mol Biol. 2005;32:462-9 pubmed
    ..In addition, the data suggest that extracellular H(2)O(2) production may be regulated by stimuli that raise intracellular Ca(2+)...
  2. Pachucki J, Wang D, Christophe D, Miot F. Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions. Mol Cell Endocrinol. 2004;214:53-62 pubmed
    ..Human ThOX1 and ThOX2 genes span 75 kb and are composed of 35 and 34 exons, respectively...
  3. Schwarzer C, Machen T, Illek B, Fischer H. NADPH oxidase-dependent acid production in airway epithelial cells. J Biol Chem. 2004;279:36454-61 pubmed
    ..These data suggest a role for an apically located Duox-based NADPH oxidase during intracellular H(+) production and H(+) secretion, but not in H(+) conduction. ..
  4. Vigone M, Fugazzola L, Zamproni I, Passoni A, Di Candia S, Chiumello G, et al. Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings. Hum Mutat. 2005;26:395 pubmed
    ..Only one study reported mutations in DUOX2 gene in congenital hypothyroidism (CH) associated with total iodide organification defect (TIOD) in homozygosity ..
  5. Lipinski S, Till A, Sina C, Arlt A, Grasberger H, Schreiber S, et al. DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses. J Cell Sci. 2009;122:3522-30 pubmed publisher
    ..We demonstrate that the NAD(P)H oxidase family member DUOX2 is involved in NOD2-dependent ROS production...
  6. Dupuy C, Ohayon R, Valent A, Noël Hudson M, Deme D, Virion A. Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J Biol Chem. 1999;274:37265-9 pubmed
    ..The gene of human p138(Tox) has been localized on chromosome 15q15. ..
  7. Geiszt M, Witta J, Baffi J, Lekstrom K, Leto T. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J. 2003;17:1502-4 pubmed
    ..the catalytic core of this enzyme, were described recently; dual oxidase (Duox)1/thyroid oxidase 1 and Duox2/thyroid oxidase 2 were identified in the thyroid gland and characterized as H2O2 donors for thyroxin biosynthesis...
  8. Harper R, Xu C, Eiserich J, Chen Y, Kao C, Thai P, et al. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Lett. 2005;579:4911-7 pubmed
    ..Increasing evidence supports the hypothesis that the dual function NAD(P)H oxidases/peroxidases, Duox1 and Duox2, are important sources of regulated H2O2 production in respiratory tract epithelium...
  9. Wu Y, Antony S, Juhasz A, Lu J, Ge Y, Jiang G, et al. Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFN-gamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines. J Biol Chem. 2011;286:12245-56 pubmed publisher
    b>Dual oxidase 2 is a member of the NADPH oxidase (Nox) gene family that plays a critical role in the biosynthesis of thyroid hormone as well as in the inflammatory response of the upper airway mucosa and in wound healing, presumably ..

More Information

Publications114 found, 100 shown here

  1. Caillou B, Dupuy C, Lacroix L, Nocera M, Talbot M, Ohayon R, et al. Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues. J Clin Endocrinol Metab. 2001;86:3351-8 pubmed
    The large homolog of NADPH oxidase flavoprotein LNOX2, and probably LNOX1, are flavoproteins involved in the thyroid H(2)O(2) generator...
  2. Lacroix L, Nocera M, Mian C, Caillou B, Virion A, Dupuy C, et al. Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas. Thyroid. 2001;11:1017-23 pubmed
    b>Duox2, and probably Duox1 are glycoflavoproteins involved in the thyroid H2O2 generator functionally associated to thyroperoxidase (TPO)...
  3. De Deken X, Wang D, Dumont J, Miot F. Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system. Exp Cell Res. 2002;273:187-96 pubmed
    We have recently cloned two thyroid-specific cDNAs encoding new members of the NADPH oxidase family. ThOX1 and ThOX2 proteins are colocalized with thyroperoxidase at the apical membrane of human thyroid cells...
  4. Ameziane El Hassani R, Morand S, Boucher J, Frapart Y, Apostolou D, Agnandji D, et al. Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity. J Biol Chem. 2005;280:30046-54 pubmed
    b>Duox2 (and probably Duox1) is a glycoflavoprotein involved in thyroid hormone biosynthesis, as the thyroid H2O2 generator functionally associated with Tpo (thyroperoxidase)...
  5. Grasberger H, Refetoff S. Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent. J Biol Chem. 2006;281:18269-72 pubmed
    b>Dual oxidase 2 (DUOX2), an NADPH:O(2) oxidoreductase flavoprotein, is a component of the thyroid H(2)O(2) generator crucial for hormone synthesis at the apical membrane. Mutations in DUOX2 produce congenital hypothyroidism in humans...
  6. Luxen S, Belinsky S, Knaus U. Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. Cancer Res. 2008;68:1037-45 pubmed publisher
    ..Here we report that the NADPH oxidases DUOX1 and DUOX2, which are one of the main sources for reactive oxygen species production in the airway, are frequently silenced ..
  7. El Hassani R, Benfares N, Caillou B, Talbot M, Sabourin J, Belotte V, et al. Dual oxidase2 is expressed all along the digestive tract. Am J Physiol Gastrointest Liver Physiol. 2005;288:G933-42 pubmed
    ..b>DUOX2 mRNA was recently detected by RT-PCR and in-situ hybridization experiments in other tissues, such as rat colon and ..
  8. Varela V, Rivolta C, Esperante S, Gruñeiro Papendieck L, Chiesa A, Targovnik H. Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A>C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect. Clin Chem. 2006;52:182-91 pubmed
    Iodide organification defects are associated with mutations in the dual oxidase 2 (DUOX2) gene and are characterized by a positive perchlorate discharge test...
  9. Mao Z, Shen S, Wan Y, Sun W, Chen H, Huang M, et al. Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid. J Ethnopharmacol. 2015;173:256-65 pubmed publisher
    ..including malondialdehyde, total superoxide dismutase, 8-hydroxy-2'-deoxyguanosine and nicotinamide adenine dinucleotide phosphate oxidase 4, but did not lower blood glucose in DN model rats...
  10. Hunt K, Srivastava R, Elmets C, Athar M. The mechanistic basis of arsenicosis: pathogenesis of skin cancer. Cancer Lett. 2014;354:211-9 pubmed publisher
    ..Arsenic promotes oxidative stress by upregulating nicotinamide adenine dinucleotide phosphate oxidase, uncoupling nitric oxide synthase, and by depleting natural antioxidants such as nitric ..
  11. Zhang Z, Hu X, Qi X, Di G, Zhang Y, Wang Q, et al. Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice. Mol Vis. 2018;24:274-285 pubmed
    ..Furthermore, RvD1 directly attenuated the accumulation of ROS and nicotinamide adenine dinucleotide phosphate oxidase 2/4 expression, while RvD1 enhanced GSH synthesis and reactivated the Nrf2-ARE signaling ..
  12. Nadesalingam A, Chen J, Farahvash A, Khan M. Hypertonic Saline Suppresses NADPH Oxidase-Dependent Neutrophil Extracellular Trap Formation and Promotes Apoptosis. Front Immunol. 2018;9:359 pubmed publisher
    ..This study found that hypertonic NaCl suppresses nicotinamide adenine dinucleotide phosphate oxidase (NADPH2 or NOX2)-dependent NETosis induced by agonists PMA, Escherichia coli LPS (..
  13. Yahyapour R, Motevaseli E, Rezaeyan A, Abdollahi H, Farhood B, Cheki M, et al. Reduction-oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics. Clin Transl Oncol. 2018;20:975-988 pubmed publisher
    ..of cyclooxygenases (COXs), nitric oxide synthase (NOSs), lipoxygenases (LOXs) as well as nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), and their effected changes in mitochondrial functions are markedly ..
  14. Watanabe T, Arita S, Shiraishi Y, Suguro T, Sakai T, Hongo S, et al. Human urotensin II promotes hypertension and atherosclerotic cardiovascular diseases. Curr Med Chem. 2009;16:550-63 pubmed
    ..U-II produces reactive oxygen species (ROS) via nicotinamide adenine dinucleotide phosphate oxidase activation in human VSMCs, and stimulates VSMC proliferation with synergistic effects when ..
  15. Jia Q, Yang R, Liu X, Wang Q, Lu H, Ma S. [Sodium hydrosulfide attenuates myocardial injury through activating thioredoxin system in diabetic rats]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1385-1391 pubmed
    ..The expression levels of Trx, Trx-interacting protein (TXNIP), and nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) in myocardium were measured using Western blotting...
  16. Ma Z, Li Y, Li W, Yan X, Yang G, Zhang J, et al. Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2017;18: pubmed publisher
    ..that PQS administration significantly suppressed the protein expression levels of nicotinamide adenine dinucleotide phosphate oxidase type 4 (Nox4), cleaved Caspase-3, cleaved Caspase-9, Bax, nuclear factor-κB (NF-κB), ..
  17. He K, Li W, Chai X, Yin Y, Jiang Y, Li W. Astragaloside IV prevents kidney injury caused by iatrogenic hyperinsulinemia in a streptozotocin?induced diabetic rat model. Int J Mol Med. 2017;: pubmed publisher
    ..b>Nicotinamide adenine dinucleotide phosphate oxidase 4 expression and extracellular signal?regulated kinase 1/2 (ERK1/2) activation were ..
  18. Dal S, Jeandidier N, Seyfritz E, Bietiger W, Péronet C, Moreau F, et al. Featured Article: Oxidative stress status and liver tissue defenses in diabetic rats during intensive subcutaneous insulin therapy. Exp Biol Med (Maywood). 2016;241:184-92 pubmed publisher
    ..Targeting oxidative stress and/or inflammation in diabetic patients could be an interesting strategy to improve therapeutic options. ..
  19. Targovnik H, Citterio C, Rivolta C. Iodide handling disorders (NIS, TPO, TG, IYD). Best Pract Res Clin Endocrinol Metab. 2017;31:195-212 pubmed publisher
    ..5 transporter (SLC5A5, encoding NIS), solute carrier family 26, member 4 transporter (SLC26A4, encoding PDS), TPO, DUOX2, DUOXA2, TG and IYD genes...
  20. Kong X, Li W, Guo L, Zhang J, Chen X, Liu W, et al. Sesamin enhances nitric oxide bioactivity in aortas of spontaneously hypertensive rats. Ther Adv Cardiovasc Dis. 2015;9:314-24 pubmed publisher
    ..nitric oxide synthase (eNOS), phosphorylated eNOS (P-eNOS), dihydrofolate reductase (DHFR), nicotinamide adenine dinucleotide phosphate oxidase subunit p47phox, and copper, zinc superoxide dismutase (Cu/Zn-SOD) in aortas was detected ..
  21. Czaja A. Nature and Implications of Oxidative and Nitrosative Stresses in Autoimmune Hepatitis. Dig Dis Sci. 2016;61:2784-2803 pubmed publisher
    ..site- and organelle-specific actions may improve outcomes, and they include inhibitors of nicotinamide adenine dinucleotide phosphate oxidase, nitric oxide synthase, and transforming growth factor beta...
  22. Sharifpanah F, De Silva S, Bekhite M, Hurtado Oliveros J, Preissner K, Wartenberg M, et al. Stimulation of vasculogenesis and leukopoiesis of embryonic stem cells by extracellular transfer RNA and ribosomal RNA. Free Radic Biol Med. 2015;89:1203-17 pubmed publisher
    ..Ex-tRNA increased NOX1, NOX2, NOX4 and DUOX2 mRNA and boosted the generation of superoxide and hydrogen peroxide which was inhibited by radical scavengers, the ..
  23. Patel S, Ali Q, Hussain T. Angiotensin II Type 2-Receptor Agonist C21 Reduces Proteinuria and Oxidative Stress in Kidney of High-Salt-Fed Obese Zucker Rats. Hypertension. 2016;67:906-15 pubmed publisher
    ..Compared with normal sodium diet controls, HSD rats exhibited increase in cortical nicotinamide adenine dinucleotide phosphate oxidase activity, urinary H2O2, and 8-isoprostanes, which were associated with severe ..
  24. Wang Z, Zhai D, Zhang D, Bai L, Yao R, Yu J, et al. Quercetin Decreases Insulin Resistance in a Polycystic Ovary Syndrome Rat Model by Improving Inflammatory Microenvironment. Reprod Sci. 2017;24:682-690 pubmed publisher
    ..The treatment inhibited the expression of inflammation-related genes, including the nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox, oxidized low-density lipoprotein, and Toll-like receptor 4, in ovarian ..
  25. Romero M, Toral M, Robles Vera I, Sanchez M, Jimenez R, O Valle F, et al. Activation of Peroxisome Proliferator Activator Receptor ?/? Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus. Hypertension. 2017;69:641-650 pubmed publisher
    ..showed reduced endothelium-dependent vasodilator responses to acetylcholine and increased nicotinamide adenine dinucleotide phosphate oxidase-driven vascular reactive oxygen species production, which were normalized by GW0742 ..
  26. Shen J, Zhang N, Lin Y, Xiang P, Liu X, Shan P, et al. Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and Its Agonists. Circ Res. 2018;122:1395-1408 pubmed publisher
    ..induced elevated cytosolic cAMP and its target, protein kinase A which in turn blocked nicotinamide adenine dinucleotide phosphate oxidase activity and reduced production of reactive oxygen species, thus blocking the ..
  27. Salmeen A, Park B, Meyer T. The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway. Oncogene. 2010;29:4473-84 pubmed publisher
    ..for growth factor-induced cell cycle entry, we show that two ROS-generating proteins, the NADPH oxidases NOX4 and DUOX2, are required for platelet-derived growth factor (PDGF) induced retinoblastoma protein (Rb) phosphorylation in ..
  28. Youn J, Zhou J, Cai H. Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus. Mol Endocrinol. 2015;29:1123-33 pubmed publisher
    ..which was attenuated by H(4)B precursor sepiapterin or small interfering RNA silencing nicotinamide adenine dinucleotide phosphate oxidase isoform 1 (NOX1)...
  29. Nie Y, Speakman J, Wu Q, Zhang C, Hu Y, Xia M, et al. ANIMAL PHYSIOLOGY. Exceptionally low daily energy expenditure in the bamboo-eating giant panda. Science. 2015;349:171-4 pubmed publisher
    ..A giant panda-unique mutation in the DUOX2 gene, critical for thyroid hormone synthesis, might explain these low thyroid hormone levels...
  30. Madlala H, Maarman G, Ojuka E. Uric acid and transforming growth factor in fructose-induced production of reactive oxygen species in skeletal muscle. Nutr Rev. 2016;74:259-66 pubmed publisher
    ..This review examines the evidence for fructose-induced production of ROS in skeletal muscle, highlights proposed mechanisms, and identifies gaps in current knowledge. ..
  31. Liu C, Liu M. Daily sesame oil supplementation attenuates local renin-angiotensin system via inhibiting MAPK activation and oxidative stress in cardiac hypertrophy. J Nutr Biochem. 2017;42:108-116 pubmed publisher
    ..Furthermore, the induction of nicotinamide adenine dinucleotide phosphate oxidase, superoxide anion and hydroxyl radical and lipid peroxidation by DOCA/salt were inhibited ..
  32. Parlato M, Charbit Henrion F, Hayes P, Tiberti A, Aloi M, Cucchiara S, et al. First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease. Gastroenterology. 2017;153:609-611.e3 pubmed publisher
  33. Jin H, Heo S, Kim Y, Kim G, Choi J, Lee B, et al. High frequency of DUOX2 mutations in transient or permanent congenital hypothyroidism with eutopic thyroid glands. Horm Res Paediatr. 2014;82:252-60 pubmed publisher
    This study aimed to clarify the frequency, phenotypes, and molecular spectrum of DUOX2, TPO, TSHR, and TG mutations in patients with congenital hypothyroidism (CH) with enlarged or normal-sized eutopic thyroid glands...
  34. Lou Z, Ren K, Tan B, Peng J, Ren X, Yang Z, et al. Salviaolate Protects Rat Brain from Ischemia-Reperfusion Injury through Inhibition of NADPH Oxidase. Planta Med. 2015;81:1361-9 pubmed publisher
  35. Cowley A, Yang C, Zheleznova N, Staruschenko A, Kurth T, Rein L, et al. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Hypertension. 2016;67:440-50 pubmed publisher
  36. Santoro V, Jia R, Thompson H, Nijhuis A, Jeffery R, Kiakos K, et al. Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer. J Natl Cancer Inst. 2016;108:djv394 pubmed publisher
    ..immunoprecipitation (ChIP) measured signal transducer and activator of transcription 1 (STAT-1) binding to dual oxidase 2 (DUOX2) promoter...
  37. Min A, Lee Y, Kim K, El Benna J, Shin M. SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4. Infect Immun. 2017;85: pubmed publisher
    ..SNAP23-dependent surface trafficking of LTB4 receptor 1 (BLT1) is required for nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-mediated exocytotic degranulation of mast cells induced by TvSP...
  38. De Ravin S, Li L, Wu X, Choi U, Allen C, Koontz S, et al. CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease. Sci Transl Med. 2017;9: pubmed publisher
    ..Whole-exome sequencing detected no indels outside of the CYBB gene after gene correction. CRISPR-mediated gene editing of HSPCs may be applicable to other CGD mutations and other monogenic disorders of the hematopoietic system. ..
  39. Cha J, Min H, Kim K, Kim J, Ghee J, Kim H, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017;97:419-431 pubmed publisher
    ..Nox1 KO, and Duox1 KO mice, but did not induce Nox activity in pMMCs from Nox2 knockout (KO), Nox4 KO, or Duox2 KO mice...
  40. Lan T, Kisseleva T, Brenner D. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. PLoS ONE. 2015;10:e0129743 pubmed publisher
    Reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate oxidase (NOX) play a key role in liver injury and fibrosis...
  41. Wang J, He C, Wu W, Chen F, Wu Y, Li W, et al. Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage and oxidative stress in a rat model of Parkinson's disease. Pharmacol Biochem Behav. 2015;138:96-103 pubmed publisher
    ..Moreover, biochanin A inhibited nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) activation and malondialdehyde (MDA) production, increased superoxide ..
  42. Harbort C, Soeiro Pereira P, von Bernuth H, Kaindl A, Costa Carvalho B, Condino Neto A, et al. Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis. Blood. 2015;126:2842-51 pubmed publisher
    ..Furthermore, we show that the oxidative burst, catalyzed by nicotinamide adenine dinucleotide phosphate oxidase, can activate ATM in neutrophils...
  43. Zempo H, Suzuki J, Watanabe R, Wakayama K, Kumagai H, Ikeda Y, et al. Cacao polyphenols ameliorate autoimmune myocarditis in mice. Hypertens Res. 2016;39:203-9 pubmed publisher
    ..Our data suggest that CPE ameliorates EAM in mice. CPE is a promising dietary supplement to suppress cardiovascular inflammation and oxidative stress. ..
  44. Choy K, Lau Y, Murugan D, Vanhoutte P, Mustafa M. Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently. J Pharmacol Exp Ther. 2018;364:420-432 pubmed publisher
    ..of Toll-like receptor 4 (TLR4), bone morphogenic protein 4 (BMP4), BMP receptor type 1A, nicotinamide adenine dinucleotide phosphate oxidase subunit 2, mitogen-activated protein kinase (MAPK), inducible nitric oxide synthase (iNOS), ..
  45. Pettigrew C, Clerkin J, Cotter T. DUOX enzyme activity promotes AKT signalling in prostate cancer cells. Anticancer Res. 2012;32:5175-81 pubmed
    ..This report shows that ROS levels in PC3 cells are constitutively maintained by DUOX enzymes, and these ROS positively regulate AKT signalling through inactivating phosphatases, leading to increased resistance to apoptosis. ..
  46. Wan W, Hollins F, Haste L, Woodman L, Hirst R, Bolton S, et al. NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma. Chest. 2016;149:1445-59 pubmed publisher
    ..Bronchial epithelial oxidative damage was determined by 8-oxo-dG expression. Nicotinamide adenine dinucleotide phosphate oxidase (NOX)/dual oxidase (DUOX) expression was assessed in bronchial epithelial cells by using ..
  47. Li Q, Mao M, Qiu Y, Liu G, Sheng T, Yu X, et al. Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension. PLoS ONE. 2016;11:e0149164 pubmed publisher
    ..These results indicated that 15-HETE-regulated ROS mediated hypoxia-induced pulmonary vascular remodeling (PVR) via the p38 MAPK pathway. ..
  48. Fatima N, Upadhyay T, Sharma D, Sharma R. Particulate beta-glucan induces early and late phagosomal maturation in murine macrophages. Front Biosci (Elite Ed). 2017;9:129-140 pubmed
    ..shown to engage dectin-1 receptor, which leads to the recruitment and activation of nicotinamide adenine dinucleotide phosphate oxidase-2 (NOX-2) and release of antimicrobial reactive oxygen species (ROS)...
  49. Chen J, Tang H, Hay N, Xu J, Ye R. Akt isoforms differentially regulate neutrophil functions. Blood. 2010;115:4237-46 pubmed publisher
    ..its membrane translocation, suggesting that Akt2 is important for the assembly of phagocyte nicotinamide adenine dinucleotide phosphate oxidase. In wild-type neutrophils, Akt2 but not Akt1 translocated to plasma membrane upon ..
  50. Lucke Wold B, Naser Z, Logsdon A, Turner R, Smith K, Robson M, et al. Amelioration of nicotinamide adenine dinucleotide phosphate-oxidase mediated stress reduces cell death after blast-induced traumatic brain injury. Transl Res. 2015;166:509-528.e1 pubmed publisher
    ..Using a clinically relevant and validated rodent blast model, we investigated how nicotinamide adenine dinucleotide phosphate oxidase (Nox) expression and associated oxidative stress contribute to cellular apoptosis after ..
  51. Bielli A, Scioli M, Mazzaglia D, Doldo E, Orlandi A. Antioxidants and vascular health. Life Sci. 2015;143:209-16 pubmed publisher
    ..stimuli promote oxidative stress generated from the increased activity of mitochondrial nicotinamide adenine dinucleotide phosphate oxidase, particularly of the Nox4 isoform, with the consequent impairment of mitochondrial β-..
  52. Potje S, Troiano J, Graton M, Ximenes V, Nakamune A, Antoniali C. Hypotensive and vasorelaxant effect of Diapocynin in normotensive rats. Free Radic Biol Med. 2017;106:148-157 pubmed publisher
    b>Nicotinamide adenine dinucleotide phosphate oxidase (NAD(P)H-oxidase) is a multicomponent enzyme system that generates superoxide anion by one-electron reduction of molecular oxygen and represents the major source of reactive oxygen ..
  53. Shlezinger N, Irmer H, Dhingra S, Beattie S, Cramer R, Braus G, et al. Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death. Science. 2017;357:1037-1041 pubmed publisher
    ..Immune surveillance exploits a fungal apoptosis-like programmed cell death pathway to maintain sterilizing immunity in the lung. ..
  54. Okamura T, Okada M, Kikuchi T, Wakizaka H, Zhang M. Kinetics and metabolism of apocynin in the mouse brain assessed with positron-emission tomography. Phytomedicine. 2018;38:84-89 pubmed publisher
    Apocynin is a constituent of the medicinal herb Picrorhiza kurroa. It is an inhibitor of nicotinamide adenine dinucleotide phosphate oxidase. This compound shows potential anti-inflammatory and antioxidant effects and has been tested as ..
  55. Zhao X, Liu J, Yang S, Song D, Wang C, Chen C, et al. Ling-Yang-Gou-Teng-decoction prevents vascular dementia through inhibiting oxidative stress induced neurovascular coupling dysfunction. J Ethnopharmacol. 2018;222:229-238 pubmed publisher
    ..LG was associated with antioxidant effects, which was confirmed as significantly decreased nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) expression, and increased superoxide dismutase 3 (SOD3) expression...
  56. Streeter J, Thiel W, Brieger K, Miller F. Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease. Cardiovasc Ther. 2013;31:125-37 pubmed publisher
  57. Trevisan G, Benemei S, Materazzi S, De Logu F, De Siena G, Fusi C, et al. TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress. Brain. 2016;139:1361-77 pubmed publisher
    ..001), which were abated by the antioxidant, ?-lipoic acid, and the nicotinamide adenine dinucleotide phosphate oxidase inhibitor, apocynin (both P < 0.001)...
  58. Ma S, Zheng X, Qiu Y, Guo M, Shao X. Compound heterozygous mutations (p.T561M and c.2422delT) in the TPO gene associated with congenital hypothyroidism. J Pediatr Endocrinol Metab. 2016;29:567-70 pubmed publisher
    ..The proband and her younger brother with GCH were enrolled for molecular analysis of the dual oxidase 2 (DUOX2), dual oxidase maturation factor 2 (DUOXA2), and thyroid peroxidase (TPO) genes...
  59. Del Pino García R, Rivero Pérez M, González Sanjosé M, Castilla Camina P, Croft K, Muñiz P. Attenuation of oxidative stress in Type 1 diabetic rats supplemented with a seasoning obtained from winemaking by-products and its effect on endothelial function. Food Funct. 2016;7:4410-4421 pubmed
    ..Other important genes for endothelial function, including endothelial ?-nicotinamide adenine dinucleotide phosphate oxidase (NOX4), endothelial and inducible nitric oxide synthases (eNOS, iNOS), and angiotensin-..
  60. Abo El Gheit R, Emam M. Targeting heme oxygenase-1 in early diabetic nephropathy in streptozotocin-induced diabetic rats. Physiol Int. 2016;103:413-427 pubmed publisher
    ..marker, NF-?B, abrogated the elevated renal hydroxyprolin, and decreased the enhanced renal nicotinamide adenine dinucleotide phosphate oxidase activity with parallel reduction of urinary oxidative stress markers...
  61. Warren M, Shimada H. Cytologic and Ultrastructural Findings of Bronchoalveolar Lavage in Patients With Chronic Granulomatous Disease. Pediatr Dev Pathol. 2017;:1093526617736188 pubmed publisher
    ..disease (CGD) is a hereditary immunodeficiency caused by mutations in genes encoding nicotinamide adenine dinucleotide phosphate oxidase enzyme complex, which lead to the inability to kill intracellular pathogens...
  62. Abe K, Narumi S, Suwanai A, Hamajima T, Hasegawa T. Pseudodominant inheritance in a family with nonautoimmune hypothyroidism due to biallelic DUOX2 mutations. Clin Endocrinol (Oxf). 2015;83:394-8 pubmed publisher
    Mutations in the dual oxidase 2 gene (DUOX2) is the most common genetic cause of congenital hypothyroidism (CH) in Japan. All previously described DUOX2 mutation-carrying families have followed autosomal recessive inheritance...
  63. Wu Y, Antony S, Hewitt S, Jiang G, Yang S, Meitzler J, et al. Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody. Int J Oncol. 2013;42:1229-38 pubmed publisher
    b>Dual oxidase 2 (Duox2), one of the seven members of the NADPH oxidase gene family, plays a critical role in generating H2O2 for thyroid hormone biosynthesis and as an integral part of the host defense system of the respiratory epithelium ..
  64. Yoshizawa Ogasawara A, Ogikubo S, Satoh M, Narumi S, Hasegawa T. Congenital hypothyroidism caused by a novel mutation of the dual oxidase 2 (DUOX2) gene. J Pediatr Endocrinol Metab. 2013;26:45-52 pubmed publisher
    The dual oxidase 2 (DUOX2) mutation results in an impairment of the hydrogen peroxidase-generating system and is identified as a dyshormonogenic cause of congenital hypothyroidism (CH)...
  65. Ko E, Choi H, Park K, Park J, Lee T, Shin D, et al. Dual oxidase 2 is essential for house dust mite-induced pro-inflammatory cytokine production in human keratinocytes. Exp Dermatol. 2015;24:936-41 pubmed publisher
    ..In this study, we found that TLR2 ligation by HDMs induced the activation of dual oxidase 2 (Duox2) and nuclear factor-κB (NF-κB), leading to the production of pro-inflammatory cytokines in human ..
  66. Krick S, Wang J, St Pierre M, Gonzalez C, Dahl G, Salathe M. Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H2O2 Production. J Biol Chem. 2016;291:6423-32 pubmed publisher
    ..The IFN-γ-induced functional down-regulation of Panx1 was due to the up-regulation of dual oxidase 2 (Duox2)...
  67. de Araujo G, Rabelo A, Meira J, Rossoni Júnior J, Castro Borges W, Guerra Sa R, et al. Baccharis trimera inhibits reactive oxygen species production through PKC and down-regulation p47 phox phosphorylation of NADPH oxidase in SK Hep-1 cells. Exp Biol Med (Maywood). 2017;242:333-343 pubmed publisher
    ..trimera on the modulation of PKC signaling pathway and to characterize the effect of the nicotinamide adenine dinucleotide phosphate oxidase enzyme (NOX) on the generation of reactive oxygen species in SK Hep-1 cells...
  68. Dupuy C, Pomerance M, Ohayon R, Noël Hudson M, Deme D, Chaaraoui M, et al. Thyroid oxidase (THOX2) gene expression in the rat thyroid cell line FRTL-5. Biochem Biophys Res Commun. 2000;277:287-92 pubmed
    ..The predicted 1517-residue polypeptide was 82.5% identical to the human THOX2/DUOX2 and 74% similar to THOX1/DUOX1...
  69. Yoshizawa Ogasawara A, Abe K, Ogikubo S, Narumi S, Hasegawa T, Satoh M. Transient congenital hypothyroidism caused by compound heterozygous mutations affecting the NADPH-oxidase domain of DUOX2. J Pediatr Endocrinol Metab. 2016;29:363-71 pubmed publisher
    ..loss-of-function mutations in the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase (NOX) domain of dual oxidase 2 (DUOX2) occurring along with concurrent missense mutations in thyroid peroxidase (TPO), leading to transient ..
  70. Song Y, Ruf J, Lothaire P, Dequanter D, Andry G, Willemse E, et al. Association of duoxes with thyroid peroxidase and its regulation in thyrocytes. J Clin Endocrinol Metab. 2010;95:375-82 pubmed publisher
    ..down-regulated through the Gs-cAMP-protein kinase A pathway, 3) H(2)O(2) increases the association of Duox1 and Duox2 to TPO in cells and in membranes, and 4) truncated NH(2)- or COOH-terminal Duox1 and Duox2 proteins show different ..
  71. Fortunato R, Lima de Souza E, Ameziane El Hassani R, Boufraqech M, Weyemi U, Talbot M, et al. Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane. J Clin Endocrinol Metab. 2010;95:5403-11 pubmed publisher
    ..For this purpose, HEK293 cells were transiently transfected with a combination of human TPO with human DUOX1 or DUOX2 in the presence of their respective maturation factors, DUOXA1 or DUOXA2...
  72. Strengert M, Jennings R, Davanture S, Hayes P, Gabriel G, Knaus U. Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection. Antioxid Redox Signal. 2014;20:2695-709 pubmed publisher
    ..Duox1 and Duox2 are the main ROS-producing enzymes in the airway epithelium, but their contribution to mammalian host defense is ..
  73. Carré A, Louzada R, Fortunato R, Ameziane El Hassani R, Morand S, Ogryzko V, et al. When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2. Antioxid Redox Signal. 2015;23:724-33 pubmed publisher
    The dual oxidase 2 (DUOX2) protein belongs to the NADPH oxidase (NOX) family. As H2O2 generator, it plays a key role in both thyroid hormone biosynthesis and innate immunity...
  74. Lu H, Wu Q, Yang H. DUOX2 promotes the elimination of the Klebsiella pneumoniae strain K5 from T24 cells through the reactive oxygen species pathway. Int J Mol Med. 2015;36:551-8 pubmed publisher
    b>Dual oxidase 2 (DUOX2) plays a major role in host defense in intestinal and airway epithelial cells through the reactive oxygen species (ROS) pathway. Klebsiella pneumoniae is a uropathogen that causes urinary tract infections...
  75. Wang J, Shao M, Liu M, Peng P, Li L, Wu W, et al. PKCα promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma. Biochem Biophys Res Commun. 2015;463:839-45 pubmed publisher
    ..PKCα stimulated generation of ROS by up-regulating DUOX2 at post-transcriptional level...
  76. Yu B, Liu Z, Fu Y, Wang Y, Zhang L, Cai Z, et al. CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling. Arterioscler Thromb Vasc Biol. 2017;37:1698-1709 pubmed publisher
    ..We further asked whether CYLD mediates AF activation via the regulation of nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) as it is an essential factor during AF transdifferentiation...
  77. Hill T, Rice R. DUOX expression in human keratinocytes and bronchial epithelial cells: Influence of vanadate. Toxicol In Vitro. 2018;46:257-264 pubmed publisher
    ..Maximal DUOX1 mRNA levels were 50 fold those of DUOX2. DUOX1 and 2 were induced ≈3 fold by interleukin 4, but only DUOX1 was induced by interferon gamma (IFNγ)...
  78. Morand S, Agnandji D, Noel Hudson M, Nicolas V, Buisson S, Macon Lemaitre L, et al. Targeting of the dual oxidase 2 N-terminal region to the plasma membrane. J Biol Chem. 2004;279:30244-51 pubmed
    b>Dual oxidase 2 (Duox2) is a cell surface glycoprotein that probably provides thyroperoxidase with the H2O2 required to catalyze thyroid hormone synthesis...
  79. De Marco G, Agretti P, Montanelli L, Di Cosmo C, Bagattini B, De Servi M, et al. Identification and functional analysis of novel dual oxidase 2 (DUOX2) mutations in children with congenital or subclinical hypothyroidism. J Clin Endocrinol Metab. 2011;96:E1335-9 pubmed publisher
    Congenital hypothyroidism (CH) associated with goiter or a gland of normal size has been linked to dual oxidase 2 (DUOX2) mutations in the presence of iodide organification defect...
  80. Wu Y, Lu J, Antony S, Juhasz A, Liu H, Jiang G, et al. Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines. J Immunol. 2013;190:1859-72 pubmed publisher
    ..oxygen species-related, gastrointestinal host defense, is regulated by IFN-γ-mediated Stat1 binding to the Duox2 promoter in pancreatic tumor lines...
  81. Park K, Park H, Kim Y, Lee K, Park J, Park J, et al. DUOX2 Mutations Are Frequently Associated With Congenital Hypothyroidism in the Korean Population. Ann Lab Med. 2016;36:145-53 pubmed publisher
    ..All coding exons of TSHR, PAX8, TPO, DUOX2, DUOXA2, and SCL5A5 were sequenced. The mutation incidence of CH was estimated to be 1 in 6,580 newborns...
  82. Maruo Y, Nagasaki K, Matsui K, Mimura Y, Mori A, Fukami M, et al. Natural course of congenital hypothyroidism by dual oxidase 2 mutations from the neonatal period through puberty. Eur J Endocrinol. 2016;174:453-63 pubmed publisher
    We previously reported that biallelic mutations in dual oxidase 2 (DUOX2) cause transient hypothyroidism. Since then, many cases with DUOX2 mutations have been reported...
  83. Aycan Z, Cangul H, Muzza M, Bas V, Fugazzola L, Chatterjee V, et al. Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism. J Clin Endocrinol Metab. 2017;102:3085-3090 pubmed publisher
    The DUOX2 enzyme generates hydrogen peroxide (H2O2), a crucial electron acceptor for the thyroid peroxidase-catalyzed iodination and coupling reactions mediating thyroid hormone biosynthesis...
  84. Hara S, Kobayashi M, Kuriiwa F, Ikematsu K, Mizukami H. Hydroxyl radical production via NADPH oxidase in rat striatum due to carbon monoxide poisoning. Toxicology. 2018;394:63-71 pubmed publisher
    ..the previous microarray finding that CO at 3000 ppm, but not 1000 ppm, enhanced mRNA expression of dual oxidase 2 (DUOX2), but not DUOX1, in rat striatum, both of which are NOX family members producing reactive oxygen ..
  85. Lambeth J. Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases. Curr Opin Hematol. 2002;9:11-7 pubmed
    ..The phagocyte nicotinamide adenine dinucleotide phosphate oxidase provides an example of deliberate reactive oxygen species generation, but the function of ..
  86. Moreno J, Bikker H, Kempers M, van Trotsenburg A, Baas F, de Vijlder J, et al. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N Engl J Med. 2002;347:95-102 pubmed
    ..of the patients and their relatives was analyzed for mutations in the genes for thyroid oxidase 1 (THOX1 ) and 2 (THOX2 )...
  87. Belforte F, Citterio C, Testa G, Olcese M, Sobrero G, Miras M, et al. Compound heterozygous DUOX2 gene mutations (c.2335-1G>C/c.3264_3267delCAGC) associated with congenital hypothyroidism. Characterization of complex cryptic splice sites by minigene analysis. Mol Cell Endocrinol. 2016;419:172-84 pubmed publisher
    ..10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2)...
  88. Fu C, Luo S, Zhang S, Wang J, Zheng H, Yang Q, et al. Next-generation sequencing analysis of DUOX2 in 192 Chinese subclinical congenital hypothyroidism (SCH) and CH patients. Clin Chim Acta. 2016;458:30-4 pubmed publisher
    Defects in the human dual oxidase 2 (DUOX2) gene are reported to be one of the major causes of congenital hypothyroidism (CH)...
  89. Kim B, Cho S, Jeon Y, An S, Jo A, Lim J, et al. Intranasal delivery of Duox2 DNA using cationic polymer can prevent acute influenza A viral infection in vivo lung. Appl Microbiol Biotechnol. 2018;102:105-115 pubmed publisher
    We studied the contribution of Duox2 in mucosal host defense against influenza A virus (IAV) infection in in vivo lung...
  90. Edens W, Sharling L, Cheng G, Shapira R, Kinkade J, Lee T, et al. Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox. J Cell Biol. 2001;154:879-91 pubmed
    ..Thus, Ce-Duox catalyzes the cross-linking of tyrosine residues involved in the stabilization of cuticular extracellular matrix. ..
  91. Luxen S, Noack D, Frausto M, Davanture S, Torbett B, Knaus U. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. J Cell Sci. 2009;122:1238-47 pubmed publisher
    ..Inactivating mutations of Duox2 have been linked to congenital hypothyroidism, and epigenetic silencing of Duox is frequently observed in lung ..
  92. MacFie T, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, et al. DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid. Inflamm Bowel Dis. 2014;20:514-24 pubmed publisher
    ..arrays, quantitative real-time polymerase chain reaction for NADPH oxidase family members, in situ hybridization (DUOX2 and DUOXA2) and immunofluorescence for DUOX, 8-OHdG (DNA damage), and ?H2AX (DNA damage response) and sought ..