DUOX1

Summary

Gene Symbol: DUOX1
Description: dual oxidase 1
Alias: LNOX1, NOXEF1, THOX1, dual oxidase 1, NADPH thyroid oxidase 1, flavoprotein NADPH oxidase, large NOX 1, long NOX 1, nicotinamide adenine dinucleotide phosphate oxidase, thyroid oxidase 1
Species: human
Products:     DUOX1

Top Publications

  1. Ameziane El Hassani R, Morand S, Boucher J, Frapart Y, Apostolou D, Agnandji D, et al. Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity. J Biol Chem. 2005;280:30046-54 pubmed
    Duox2 (and probably Duox1) is a glycoflavoprotein involved in thyroid hormone biosynthesis, as the thyroid H2O2 generator functionally associated with Tpo (thyroperoxidase)...
  2. Pachucki J, Wang D, Christophe D, Miot F. Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions. Mol Cell Endocrinol. 2004;214:53-62 pubmed
    ..Human ThOX1 and ThOX2 genes span 75 kb and are composed of 35 and 34 exons, respectively...
  3. Luxen S, Noack D, Frausto M, Davanture S, Torbett B, Knaus U. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. J Cell Sci. 2009;122:1238-47 pubmed publisher
    ..Functional Duox1 and Duox2 localize to the leading edge of migrating cells, augmenting motility and wound healing...
  4. Geiszt M, Witta J, Baffi J, Lekstrom K, Leto T. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J. 2003;17:1502-4 pubmed
    ..homologues of gp91phox, the catalytic core of this enzyme, were described recently; dual oxidase (Duox)1/thyroid oxidase 1 and Duox2/thyroid oxidase 2 were identified in the thyroid gland and characterized as H2O2 donors for ..
  5. Shao M, Nadel J. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2005;102:767-72 pubmed
    ..b>Dual oxidase 1 (Duox1), a homologue of glycoprotein p91(phox), is expressed in airway epithelium and generates ROS...
  6. Wesley U, Bove P, Hristova M, McCarthy S, van Der Vliet A. Airway epithelial cell migration and wound repair by ATP-mediated activation of dual oxidase 1. J Biol Chem. 2007;282:3213-20 pubmed
    ..Here, we report a critical role for dual oxidase 1 (Duox1), a newly identified NADPH oxidase homolog within the tracheobronchial epithelium, in airway epithelial ..
  7. Caillou B, Dupuy C, Lacroix L, Nocera M, Talbot M, Ohayon R, et al. Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues. J Clin Endocrinol Metab. 2001;86:3351-8 pubmed
    The large homolog of NADPH oxidase flavoprotein LNOX2, and probably LNOX1, are flavoproteins involved in the thyroid H(2)O(2) generator...
  8. Schwarzer C, Machen T, Illek B, Fischer H. NADPH oxidase-dependent acid production in airway epithelial cells. J Biol Chem. 2004;279:36454-61 pubmed
    ..We determined levels of transcripts for the NADPH oxidase transmembrane isoforms (Nox1 through -5, Duox1 and -2, and p22(phox)) and found Duox1, -2, and p22(phox) to be highly expressed in hTE, as well as the ..
  9. Harper R, Xu C, Eiserich J, Chen Y, Kao C, Thai P, et al. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Lett. 2005;579:4911-7 pubmed
    ..Increasing evidence supports the hypothesis that the dual function NAD(P)H oxidases/peroxidases, Duox1 and Duox2, are important sources of regulated H2O2 production in respiratory tract epithelium...

More Information

Publications106 found, 100 shown here

  1. Dupuy C, Ohayon R, Valent A, Noël Hudson M, Deme D, Virion A. Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J Biol Chem. 1999;274:37265-9 pubmed
    ..The gene of human p138(Tox) has been localized on chromosome 15q15. ..
  2. Rigutto S, Hoste C, Grasberger H, Milenkovic M, Communi D, Dumont J, et al. Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation. J Biol Chem. 2009;284:6725-34 pubmed publisher
    ..However, the Duox1 function in thyroid remains elusive...
  3. Flores M, Crawford K, Pullin L, Hall C, Crosier K, Crosier P. Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties. Biochem Biophys Res Commun. 2010;400:164-8 pubmed publisher
    ..Zebrafish duox is highly expressed in intestinal epithelial cells. Knockdown of Duox impaired larval capacity to control enteric Salmonella infection. ..
  4. Wang L, Zhen H, Yao W, Bian F, Zhou F, Mao X, et al. Lipid raft-dependent activation of dual oxidase 1/H2O2/NF-?B pathway in bronchial epithelial cells. Am J Physiol Cell Physiol. 2011;301:C171-80 pubmed publisher
    The present study addressed whether dual oxidase 1 (Duox1), a predominant isoform of NADPH oxidase in bronchial epithelial cells, is also activated through assembling of Duox1 and its partners such as p47(phox) due to lipid raft (LR) ..
  5. De Deken X, Wang D, Dumont J, Miot F. Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system. Exp Cell Res. 2002;273:187-96 pubmed
    We have recently cloned two thyroid-specific cDNAs encoding new members of the NADPH oxidase family. ThOX1 and ThOX2 proteins are colocalized with thyroperoxidase at the apical membrane of human thyroid cells...
  6. De Deken X, Wang D, Many M, Costagliola S, Libert F, Vassart G, et al. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem. 2000;275:23227-33 pubmed
    ..thyroid cells in primary culture yielded two distinct human cDNA clones harboring open reading frames of 1551 (ThOX1) and 1548 amino acids (ThOX2), respectively...
  7. Forteza R, Salathe M, Miot F, Forteza R, Conner G. Regulated hydrogen peroxide production by Duox in human airway epithelial cells. Am J Respir Cell Mol Biol. 2005;32:462-9 pubmed
    ..in human airway epithelia redifferentiated at the air-liquid interface (ALI) and demonstrated the presence of Duox1 and 2...
  8. Sham D, Wesley U, Hristova M, van Der Vliet A. ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. PLoS ONE. 2013;8:e54391 pubmed publisher
    ..Based on previous studies indicating involvement of ATP-dependent activation of the NADPH oxidase homolog DUOX1 in epithelial wound responses, the present studies were performed to elucidate the mechanisms by which DUOX1-..
  9. Mao Z, Shen S, Wan Y, Sun W, Chen H, Huang M, et al. Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid. J Ethnopharmacol. 2015;173:256-65 pubmed publisher
    ..including malondialdehyde, total superoxide dismutase, 8-hydroxy-2'-deoxyguanosine and nicotinamide adenine dinucleotide phosphate oxidase 4, but did not lower blood glucose in DN model rats...
  10. Hunt K, Srivastava R, Elmets C, Athar M. The mechanistic basis of arsenicosis: pathogenesis of skin cancer. Cancer Lett. 2014;354:211-9 pubmed publisher
    ..Arsenic promotes oxidative stress by upregulating nicotinamide adenine dinucleotide phosphate oxidase, uncoupling nitric oxide synthase, and by depleting natural antioxidants such as nitric ..
  11. Watanabe T, Arita S, Shiraishi Y, Suguro T, Sakai T, Hongo S, et al. Human urotensin II promotes hypertension and atherosclerotic cardiovascular diseases. Curr Med Chem. 2009;16:550-63 pubmed
    ..U-II produces reactive oxygen species (ROS) via nicotinamide adenine dinucleotide phosphate oxidase activation in human VSMCs, and stimulates VSMC proliferation with synergistic effects when ..
  12. Jia Q, Yang R, Liu X, Wang Q, Lu H, Ma S. [Sodium hydrosulfide attenuates myocardial injury through activating thioredoxin system in diabetic rats]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1385-1391 pubmed
    ..The expression levels of Trx, Trx-interacting protein (TXNIP), and nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) in myocardium were measured using Western blotting...
  13. Ma Z, Li Y, Li W, Yan X, Yang G, Zhang J, et al. Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2017;18: pubmed publisher
    ..that PQS administration significantly suppressed the protein expression levels of nicotinamide adenine dinucleotide phosphate oxidase type 4 (Nox4), cleaved Caspase-3, cleaved Caspase-9, Bax, nuclear factor-κB (NF-κB), ..
  14. He K, Li W, Chai X, Yin Y, Jiang Y, Li W. Astragaloside IV prevents kidney injury caused by iatrogenic hyperinsulinemia in a streptozotocin?induced diabetic rat model. Int J Mol Med. 2017;: pubmed publisher
    ..b>Nicotinamide adenine dinucleotide phosphate oxidase 4 expression and extracellular signal?regulated kinase 1/2 (ERK1/2) activation were ..
  15. Dal S, Jeandidier N, Seyfritz E, Bietiger W, Péronet C, Moreau F, et al. Featured Article: Oxidative stress status and liver tissue defenses in diabetic rats during intensive subcutaneous insulin therapy. Exp Biol Med (Maywood). 2016;241:184-92 pubmed publisher
    ..Targeting oxidative stress and/or inflammation in diabetic patients could be an interesting strategy to improve therapeutic options. ..
  16. Kong X, Li W, Guo L, Zhang J, Chen X, Liu W, et al. Sesamin enhances nitric oxide bioactivity in aortas of spontaneously hypertensive rats. Ther Adv Cardiovasc Dis. 2015;9:314-24 pubmed publisher
    ..nitric oxide synthase (eNOS), phosphorylated eNOS (P-eNOS), dihydrofolate reductase (DHFR), nicotinamide adenine dinucleotide phosphate oxidase subunit p47phox, and copper, zinc superoxide dismutase (Cu/Zn-SOD) in aortas was detected ..
  17. Czaja A. Nature and Implications of Oxidative and Nitrosative Stresses in Autoimmune Hepatitis. Dig Dis Sci. 2016;61:2784-2803 pubmed publisher
    ..site- and organelle-specific actions may improve outcomes, and they include inhibitors of nicotinamide adenine dinucleotide phosphate oxidase, nitric oxide synthase, and transforming growth factor beta...
  18. Wang Z, Zhai D, Zhang D, Bai L, Yao R, Yu J, et al. Quercetin Decreases Insulin Resistance in a Polycystic Ovary Syndrome Rat Model by Improving Inflammatory Microenvironment. Reprod Sci. 2017;24:682-690 pubmed publisher
    ..The treatment inhibited the expression of inflammation-related genes, including the nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox, oxidized low-density lipoprotein, and Toll-like receptor 4, in ovarian ..
  19. Romero M, Toral M, Robles Vera I, Sanchez M, Jimenez R, O Valle F, et al. Activation of Peroxisome Proliferator Activator Receptor ?/? Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus. Hypertension. 2017;69:641-650 pubmed publisher
    ..showed reduced endothelium-dependent vasodilator responses to acetylcholine and increased nicotinamide adenine dinucleotide phosphate oxidase-driven vascular reactive oxygen species production, which were normalized by GW0742 ..
  20. Shen J, Zhang N, Lin Y, Xiang P, Liu X, Shan P, et al. Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and Its Agonists. Circ Res. 2018;122:1395-1408 pubmed publisher
    ..induced elevated cytosolic cAMP and its target, protein kinase A which in turn blocked nicotinamide adenine dinucleotide phosphate oxidase activity and reduced production of reactive oxygen species, thus blocking the ..
  21. Carestia A, Kaufman T, Rivadeneyra L, Landoni V, Pozner R, Negrotto S, et al. Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets. J Leukoc Biol. 2016;99:153-62 pubmed publisher
    ..kinase, phosphatidylinositol 3-kinase, and Src kinases, but not p38 or reduced nicotinamide adenine dinucleotide phosphate oxidase, was involved in platelet-triggered neutrophil extracellular trap release...
  22. Fraga Silva R, Costa Fraga F, Montecucco F, Sturny M, Faye Y, Mach F, et al. Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury. J Sex Med. 2015;12:289-302 pubmed publisher
    ..Additionally, treatment with DIZE improved hypercholesterolemia-induced CC injury, suggesting ACE2 as a potential target for treating ED. . ..
  23. Leticia F, Anita I. Adrenomedullin and angiotensin II signaling pathways involved in the effects on cerebellar antioxidant enzymes activity. Brain Res Bull. 2017;128:83-91 pubmed publisher
    ..the role of angiotensin II (ANG II), protein kinase A (PKA) activity, and protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase (PKC/NAD(P)H) (oxidase) pathway...
  24. Liu C, Liu M. Daily sesame oil supplementation attenuates local renin-angiotensin system via inhibiting MAPK activation and oxidative stress in cardiac hypertrophy. J Nutr Biochem. 2017;42:108-116 pubmed publisher
    ..Furthermore, the induction of nicotinamide adenine dinucleotide phosphate oxidase, superoxide anion and hydroxyl radical and lipid peroxidation by DOCA/salt were inhibited ..
  25. Abais J, Xia M, Li G, Gehr T, Boini K, Li P. Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia. Free Radic Biol Med. 2014;67:211-20 pubmed publisher
    ..Recent studies have demonstrated the implication of nicotinamide adenine dinucleotide phosphate oxidase-mediated NLRP3 inflammasome activation in the development of podocyte injury and glomerular ..
  26. Qaradakhi T, Apostolopoulos V, Zulli A. Angiotensin (1-7) and Alamandine: Similarities and differences. Pharmacol Res. 2016;111:820-826 pubmed publisher
    ..and receptors which increase nitric oxide release from the endothelium and decrease nicotinamide adenine dinucleotide phosphate oxidase-related superoxide production...
  27. Cha J, Min H, Kim K, Kim J, Ghee J, Kim H, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017;97:419-431 pubmed publisher
    ..that TGF-β stimulated ROS generation in primary mouse mesangial cells (pMMCs) from wild-type, Nox1 KO, and Duox1 KO mice, but did not induce Nox activity in pMMCs from Nox2 knockout (KO), Nox4 KO, or Duox2 KO mice...
  28. Streeter J, Thiel W, Brieger K, Miller F. Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease. Cardiovasc Ther. 2013;31:125-37 pubmed publisher
  29. Silva E, Soares A, Costa F, Castro J, Matos L, Almeida H. Antioxidant Supplementation Modulates Age-Related Placental Bed Morphology and Reproductive Outcome in Mice. Biol Reprod. 2015;93:56 pubmed publisher
    ..To test this hypothesis, two different antioxidants, the nicotinamide adenine dinucleotide phosphate oxidase (NOX) inhibitor apocynin and the superoxide dismutase mimetic 4-hydroxy-2,2,6,6-..
  30. Virdis A, Tani C, Duranti E, Vagnani S, Carli L, Kühl A, et al. Early treatment with hydroxychloroquine prevents the development of endothelial dysfunction in a murine model of systemic lupus erythematosus. Arthritis Res Ther. 2015;17:277 pubmed publisher
    ..The ED that characterizes this mouse model of SLE is caused by the nicotinamide adenine dinucleotide phosphate oxidase-driven ROS excess...
  31. Chen S, Yin L, Xu Z, An F, Liu A, Wang Y, et al. Inhibiting receptor for advanced glycation end product (AGE) and oxidative stress involved in the protective effect mediated by glucagon-like peptide-1 receptor on AGE induced neuronal apoptosis. Neurosci Lett. 2016;612:193-198 pubmed publisher
    ..In summary, the results indicated that inhibiting RAGE/oxidative stress was involved in the protective effect of GLP-1 on neuron cells against AGEs induced apoptosis. ..
  32. Antonopoulos A, Margaritis M, Verheule S, Recalde A, Sanna F, Herdman L, et al. Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling. Circ Res. 2016;118:842-55 pubmed publisher
    ..that increase ADIPOQ expression (encoding adiponectin) led to reduced myocardial nicotinamide adenine dinucleotide phosphate oxidase-derived O2 (-), whereas circulating adiponectin and ADIPOQ expression in EpAT were ..
  33. Sasakura H, Moribe H, Nakano M, Ikemoto K, Takeuchi K, Mori I. Lifespan extension by peroxidase and dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans. J Cell Sci. 2017;130:2631-2643 pubmed publisher
    ..Cell biology experiments demonstrated a similarity between the mechanisms of PQQ-induced activation of human DUOX1 and DUOX2 and that of C...
  34. Lu H, Wu Q, Yang H. DUOX2 promotes the elimination of the Klebsiella pneumoniae strain K5 from T24 cells through the reactive oxygen species pathway. Int J Mol Med. 2015;36:551-8 pubmed publisher
    ..Our findings also provide insight into the protection of uroepithelial cells from Klebsiella pneumoniae K5 bacterial cytoinvasion, and thus lay the foundation for the development of novel therapies for urinary tract infections. ..
  35. Costa S, Reina Couto M, Albino Teixeira A, Sousa T. Statins and oxidative stress in chronic heart failure. Rev Port Cardiol. 2016;35:41-57 pubmed publisher
    ..By regulating several molecular pathways that control nicotinamide adenine dinucleotide phosphate oxidase and endothelial nitric oxide synthase activity, statins help restore redox homeostasis...
  36. Fatima N, Upadhyay T, Sharma D, Sharma R. Particulate beta-glucan induces early and late phagosomal maturation in murine macrophages. Front Biosci (Elite Ed). 2017;9:129-140 pubmed
    ..shown to engage dectin-1 receptor, which leads to the recruitment and activation of nicotinamide adenine dinucleotide phosphate oxidase-2 (NOX-2) and release of antimicrobial reactive oxygen species (ROS)...
  37. Marreiro D, Cruz K, Morais J, Beserra J, Severo J, de Oliveira A. Zinc and Oxidative Stress: Current Mechanisms. Antioxidants (Basel). 2017;6: pubmed publisher
    ..against oxidative damage, acts in the stabilization of membranes and inhibits the enzyme nicotinamide adenine dinucleotide phosphate oxidase (NADPH-Oxidase)...
  38. Menden H, Xia S, Mabry S, Navarro A, Nyp M, Sampath V. Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Regulates LPS-Induced Inflammation and Alveolar Remodeling in the Developing Lung. Am J Respir Cell Mol Biol. 2016;55:767-778 pubmed
    ..We developed a neonatal mouse model of sepsis-induced lung injury to investigate whether nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) regulates Toll-like receptor (TLR)-mediated inflammation and alveolar remodeling...
  39. Lee J, Kagan E. Role of nicotinamide adenine dinucleotide phosphate oxidase in mediating vesicant-induced interleukin-6 secretion in human airway epithelial cells. Am J Respir Cell Mol Biol. 2014;50:713-22 pubmed publisher
    ..Furthermore, knockdown of DUOX1 or DUOX2 by short hairpin RNA resulted in inhibition of ROS generation, EGFR pathway activation, and IL-6 ..
  40. Trevisan G, Benemei S, Materazzi S, De Logu F, De Siena G, Fusi C, et al. TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress. Brain. 2016;139:1361-77 pubmed publisher
    ..001), which were abated by the antioxidant, ?-lipoic acid, and the nicotinamide adenine dinucleotide phosphate oxidase inhibitor, apocynin (both P < 0.001)...
  41. Sirokmány G, Pató A, Zana M, Donkó A, Biro A, Nagy P, et al. Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1. Free Radic Biol Med. 2016;97:204-211 pubmed publisher
    ..of NADPH oxidase isoforms and found both A431 and HaCaT cells to express the calcium-sensitive NADPH oxidase, Dual oxidase 1 (Duox1) and its protein partner Duox activator 1 (DuoxA1)...
  42. Little A, Sham D, Hristova M, Danyal K, Heppner D, Bauer R, et al. DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties. Oncogenesis. 2016;5:e261 pubmed publisher
    b>Dual oxidase 1 (DUOX1) is an oxidant-generating enzyme within the airway epithelium that participates in innate airway host defense and epithelial homeostasis...
  43. Bielli A, Scioli M, Mazzaglia D, Doldo E, Orlandi A. Antioxidants and vascular health. Life Sci. 2015;143:209-16 pubmed publisher
    ..stimuli promote oxidative stress generated from the increased activity of mitochondrial nicotinamide adenine dinucleotide phosphate oxidase, particularly of the Nox4 isoform, with the consequent impairment of mitochondrial β-..
  44. Jiang S, Hu L, Ping L, Sun F, Wang X. Glutathione protects against hepatic injury in a murine model of primary Sjögren's syndrome. Bosn J Basic Med Sci. 2016;16:227-31 pubmed publisher
    ..GSH, tumor necrosis factor, interleukin (IL) 10, integrin alpha M, IL1B, malondialdehyde, nicotinamide adenine dinucleotide phosphate oxidase 4, and superoxide dismutases in hepatocyte homogenates...
  45. Alves Lopes R, Neves K, Montezano A, Harvey A, Carneiro F, Touyz R, et al. Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase-Dependent Mechanisms. Hypertension. 2016;68:1056-64 pubmed publisher
    ..that downregulation of nuclear factor E2-related factor 2 (Nrf2), consequent to increased nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1)-derived reactive oxygen species (ROS), impairs IPA function in DM...
  46. Ahmadinejad F, Geir Møller S, Hashemzadeh Chaleshtori M, Bidkhori G, Jami M. Molecular Mechanisms behind Free Radical Scavengers Function against Oxidative Stress. Antioxidants (Basel). 2017;6: pubmed publisher
  47. Chang S, Linderholm A, Harper R. DUOX-Mediated Signaling Is Not Required for LPS-Induced Neutrophilic Response in the Airways. PLoS ONE. 2015;10:e0131810 pubmed publisher
    Oxidant production from DUOX1 has been proposed to lead to neutrophil recruitment into the airways when lung homeostasis is compromised...
  48. Weisser M, Demel U, Stein S, Chen Wichmann L, Touzot F, Santilli G, et al. Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions. J Allergy Clin Immunol. 2016;138:219-228.e9 pubmed publisher
    Defects in phagocytic nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) function cause chronic granulomatous disease (CGD), a primary immunodeficiency characterized by dysfunctional microbicidal activity and chronic ..
  49. Abo El Gheit R, Emam M. Targeting heme oxygenase-1 in early diabetic nephropathy in streptozotocin-induced diabetic rats. Physiol Int. 2016;103:413-427 pubmed publisher
    ..marker, NF-?B, abrogated the elevated renal hydroxyprolin, and decreased the enhanced renal nicotinamide adenine dinucleotide phosphate oxidase activity with parallel reduction of urinary oxidative stress markers...
  50. Conti F, Lugo Reyes S, Blancas Galicia L, He J, Aksu G, Borges de Oliveira E, et al. Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases. J Allergy Clin Immunol. 2016;138:241-248.e3 pubmed publisher
    ..disease (CGD) is a rare primary immunodeficiency caused by inborn errors of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase complex...
  51. Zhang B, Bailey W, McVicar A, Gensel J. Age increases reactive oxygen species production in macrophages and potentiates oxidative damage after spinal cord injury. Neurobiol Aging. 2016;47:157-167 pubmed publisher
    ..b>Nicotinamide adenine dinucleotide phosphate oxidase (NOX) contributes to reactive oxygen species (ROS)-mediated damage and macrophage ..
  52. Bubb K, Birgisdottir A, Tang O, Hansen T, Figtree G. Redox modification of caveolar proteins in the cardiovascular system- role in cellular signalling and disease. Free Radic Biol Med. 2017;109:61-74 pubmed publisher
    ..that reside in the immediate vicinity of the two major cellular sources of ROS, nicotinamide adenine dinucleotide phosphate oxidase (Nox) and uncoupled endothelial nitric oxide synthase (eNOS)...
  53. Zhang X, Cao X, Zhang C, Zhao Z. 17β-estradiol protects against doxorubicin-induced cardiotoxicity in male Sprague-Dawley rats by regulating NADPH oxidase and apoptosis genes. Mol Med Rep. 2017;15:2695-2702 pubmed publisher
    ..E2 treatment inhibited the DOX‑induced increase in the expression of cardiac genes, nicotinamide adenine dinucleotide phosphate oxidase (NOX) 2, NOX4, B‑cell lymphoma 2‑associated X protein and caspase 3...
  54. Tahmasbpour Marzony E, Nejad Moghadam A, Ghanei M, Panahi Y. Sulfur mustard causes oxidants/antioxidants imbalance through the overexpression of free radical producing-related genes in human mustard lungs. Environ Toxicol Pharmacol. 2016;45:187-92 pubmed publisher
    ..6467±0.05922 nmol/l). All ROS producing-related genes were overexpressed in the order AOX1>MPO>DUOX2>DUOX1>TPO>EPO...
  55. Hernández Saavedra D, Sanders L, Perez M, Kosmider B, Smith L, Mitchell J, et al. RTP801 Amplifies Nicotinamide Adenine Dinucleotide Phosphate Oxidase-4-Dependent Oxidative Stress Induced by Cigarette Smoke. Am J Respir Cell Mol Biol. 2017;56:62-73 pubmed publisher
    ..that in Rtp801 Wt cells after CSE treatment, and it was inhibited in Wt MLF by silencing nicotinamide adenine dinucleotide phosphate oxidase-4 (Nox4) expression with small interfering Nox4 RNA...
  56. Sakai Y, Yamamori T, Yoshikawa Y, Bo T, Suzuki M, Yamamoto K, et al. NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells. Free Radic Res. 2018;52:92-102 pubmed publisher
    ..Among all six murine NOX isoforms (NOX1-4 and DUOX1/2), only NOX4 was detectable under basal conditions and was upregulated following IR...
  57. Kim S, Hur D, Hong S, Kim J. EBV-encoded EBNA1 regulates cell viability by modulating miR34a-NOX2-ROS signaling in gastric cancer cells. Biochem Biophys Res Commun. 2017;494:550-555 pubmed publisher
    ..to contribute to tumor progression through an increase in reactive oxygen species via nicotinamide adenine dinucleotide phosphate oxidase. However, the underlying molecular mechanism of EBNA1-induced ROS accumulation in gastric ..
  58. Lu C, Qiu J, Huang P, Zou R, Hong J, Li B, et al. NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy. Tumour Biol. 2011;32:1173-82 pubmed publisher
    NADPH oxidase DUOX1, DUOX2, and NOX4 have recently been gained considerable concerns, owing to the fact that they involve in reactive oxygen species-induced genetic and epigenetic alternations of human carcinogenesis and serve as ..
  59. Schnider D, Rieder S, Leeb T, Gerber V, Neuditschko M. A genome-wide association study for equine recurrent airway obstruction in European Warmblood horses reveals a suggestive new quantitative trait locus on chromosome 13. Anim Genet. 2017;48:691-693 pubmed publisher
    ..the protein-coding gene TXNDC11, which is possibly involved in the folding process of the multiprotein complexes DUOX1 and DUOX2...
  60. Ke K, Sul O, Chung S, Suh J, Choi H. Lack of NOD2 attenuates ovariectomy-induced bone loss via inhibition of osteoclasts. J Endocrinol. 2017;235:85-96 pubmed publisher
    ..NOD2 was found to physically interact with nicotinamide adenine dinucleotide phosphate oxidase 1, and this led to increased production of ROS in OCs...
  61. Cao Z, Ye T, Sun Y, Ji G, Shido K, Chen Y, et al. Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis. Sci Transl Med. 2017;9: pubmed publisher
    ..Our data suggest that targeting dysfunctional perivascular and vascular cells in diseased organs can bypass fibrosis and enable reparative cell engraftment to reinstate lung and liver regeneration. ..
  62. Pettigrew C, Clerkin J, Cotter T. DUOX enzyme activity promotes AKT signalling in prostate cancer cells. Anticancer Res. 2012;32:5175-81 pubmed
    ..This report shows that ROS levels in PC3 cells are constitutively maintained by DUOX enzymes, and these ROS positively regulate AKT signalling through inactivating phosphatases, leading to increased resistance to apoptosis. ..
  63. Wang D, De Deken X, Milenkovic M, Song Y, Pirson I, Dumont J, et al. Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. J Biol Chem. 2005;280:3096-103 pubmed
    ..By yeast two-hybrid method using EF-hand fragment of dog Duox1 as the bait we have isolated EFP1 (EF-hand binding protein 1), one partner of Duoxs that belongs to the ..
  64. Eun H, Cho S, Joo J, Kang S, Moon H, Lee E, et al. Gene expression of NOX family members and their clinical significance in hepatocellular carcinoma. Sci Rep. 2017;7:11060 pubmed publisher
    ..In addition, HCC survival analyses indicated better overall survival in patients with high NOX4 and DUOX1 expression, whereas patients with high NOX1/2/5 expression showed poor prognoses...
  65. Edens W, Sharling L, Cheng G, Shapira R, Kinkade J, Lee T, et al. Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox. J Cell Biol. 2001;154:879-91 pubmed
    ..Ce-Duox1 is expressed in hypodermal cells underlying the cuticle of larval animals...
  66. Williams D, Kadaria D, Sodhi A, Fox R, Williams G, Threlkeld S. Chronic Granulomatous Disease Presenting as Aspergillus Fumigatus Pneumonia in a Previously Healthy Young Woman. Am J Case Rep. 2017;18:351-354 pubmed
    ..Clinicians should consider this disease in patients presenting with recurrent or non-resolving infections. Timely treatment and prophylaxis has been shown to reduce serious infections as well as mortality in these patients...
  67. Song Y, Ruf J, Lothaire P, Dequanter D, Andry G, Willemse E, et al. Association of duoxes with thyroid peroxidase and its regulation in thyrocytes. J Clin Endocrinol Metab. 2010;95:375-82 pubmed publisher
    ..pathway and down-regulated through the Gs-cAMP-protein kinase A pathway, 3) H(2)O(2) increases the association of Duox1 and Duox2 to TPO in cells and in membranes, and 4) truncated NH(2)- or COOH-terminal Duox1 and Duox2 proteins show ..
  68. Zhang M, Hou Y, Shen Y, Guo X, Shang D, Zhang D. Probucol reverses homocysteine induced inflammatory monocytes differentiation and oxidative stress. Eur J Pharmacol. 2018;818:67-73 pubmed publisher
    ..The activity of nicotinamide adenine dinucleotide phosphate oxidase in THP-1 cells was measured by assay kit on enzyme-labelling instrument...
  69. Hara S, Kobayashi M, Kuriiwa F, Ikematsu K, Mizukami H. Hydroxyl radical production via NADPH oxidase in rat striatum due to carbon monoxide poisoning. Toxicology. 2018;394:63-71 pubmed publisher
    ..finding that CO at 3000?ppm, but not 1000?ppm, enhanced mRNA expression of dual oxidase 2 (DUOX2), but not DUOX1, in rat striatum, both of which are NOX family members producing reactive oxygen species...
  70. Lacroix L, Nocera M, Mian C, Caillou B, Virion A, Dupuy C, et al. Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas. Thyroid. 2001;11:1017-23 pubmed
    Duox2, and probably Duox1 are glycoflavoproteins involved in the thyroid H2O2 generator functionally associated to thyroperoxidase (TPO)...
  71. Aycan Z, Cangul H, Muzza M, Bas V, Fugazzola L, Chatterjee V, et al. Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism. J Clin Endocrinol Metab. 2017;102:3085-3090 pubmed publisher
    ..dietary iodine) and oligogenic modifiers (e.g., variants in the homologous reduced form of NAD phosphate-oxidase DUOX1)...
  72. Wang X, Yang J, Ji C, Zeng X, Shi G, Fisher M, et al. Inhibition of NADPH Oxidase-Dependent Oxidative Stress in the Rostral Ventrolateral Medulla Mediates the Antihypertensive Effects of Acupuncture in Spontaneously Hypertensive Rats. Hypertension. 2018;71:356-365 pubmed publisher
    ..Oxidative stress in the RVLM was alleviated by acupuncture, accompanied by a decrease in nicotinamide adenine dinucleotide phosphate oxidase activity and expression of its subunits...
  73. Ko E, Choi H, Kim B, Kim M, Park K, Bae I, et al. Testosterone stimulates Duox1 activity through GPRC6A in skin keratinocytes. J Biol Chem. 2014;289:28835-45 pubmed publisher
    ..complex is required for activation of Gq protein, IP3 generation, and [Ca(2+)]i mobilization, leading to Duox1 activation...
  74. Hill T, Rice R. DUOX expression in human keratinocytes and bronchial epithelial cells: Influence of vanadate. Toxicol In Vitro. 2018;46:257-264 pubmed publisher
    ..Both DUOX1 and 2 were expressed at much higher levels after confluence than in the preconfluent state...
  75. Lee P, West C, Crain K, Wang L. Genetic polymorphisms and susceptibility to lung disease. J Negat Results Biomed. 2006;5:5 pubmed
    ..polymorphisms in ten genes: p47phox (NCF1), p67phox (NCF2), p40phox (NCF4), p22phox (CYBA), gp91phox (CYBB), DUOX1, DUOX2, TLR2, TLR9 and alpha 1-antitrypsin (AAT) in a cohort of 95 lung disease individuals and 95 control ..
  76. Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed M, et al. Low-level laser therapy for beta amyloid toxicity in rat hippocampus. Neurobiol Aging. 2017;49:165-182 pubmed publisher
    ..triphosphate synthesis; (6) suppressed Aβ-induced glucose-6-phosphate dehydrogenase and nicotinamide adenine dinucleotide phosphate oxidase activity; (7) enhanced the total antioxidant capacity of hippocampal CA1 neurons, whereas ..
  77. Nagai K, Betsuyaku T, Suzuki M, Nasuhara Y, Kaga K, Kondo S, et al. Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease. Antioxid Redox Signal. 2008;10:705-14 pubmed publisher
    ..We investigated the epithelial expression of Duox1 and Duox2 in the airways of smokers, and the relationship between this expression and COPD at early stage...
  78. Ameziane El Hassani R, Talbot M, de Souza Dos Santos M, Al Ghuzlan A, Hartl D, Bidart J, et al. NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation. Proc Natl Acad Sci U S A. 2015;112:5051-6 pubmed publisher
    ..Our results show that IR induces delayed NADPH oxidase DUOX1-dependent H2O2 production in a dose-dependent manner, which is sustained for several days...
  79. Toklu H, Scarpace P, Sakarya Y, Kirichenko N, Matheny M, Bruce E, et al. Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway. Appl Physiol Nutr Metab. 2017;42:59-67 pubmed publisher
    ..Tempol significantly decreased (p < 0.01) nicotinamide adenine dinucleotide phosphate oxidase activity in the hypothalamus but failed to reduce food intake or weight gain and did not ..
  80. Fischer H, Gonzales L, Kolla V, Schwarzer C, Miot F, Illek B, et al. Developmental regulation of DUOX1 expression and function in human fetal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1506-14 pubmed
    The purpose of this study was to determine the expression and cellular functions of the epithelial NADPH oxidase DUOX1 during alveolar type II cell development...
  81. Shlezinger N, Irmer H, Dhingra S, Beattie S, Cramer R, Braus G, et al. Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death. Science. 2017;357:1037-1041 pubmed publisher
    ..Immune surveillance exploits a fungal apoptosis-like programmed cell death pathway to maintain sterilizing immunity in the lung. ..
  82. de Araujo G, Rabelo A, Meira J, Rossoni Júnior J, Castro Borges W, Guerra Sa R, et al. Baccharis trimera inhibits reactive oxygen species production through PKC and down-regulation p47 phox phosphorylation of NADPH oxidase in SK Hep-1 cells. Exp Biol Med (Maywood). 2017;242:333-343 pubmed publisher
    ..trimera on the modulation of PKC signaling pathway and to characterize the effect of the nicotinamide adenine dinucleotide phosphate oxidase enzyme (NOX) on the generation of reactive oxygen species in SK Hep-1 cells...
  83. Lambeth J. Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases. Curr Opin Hematol. 2002;9:11-7 pubmed
    ..The phagocyte nicotinamide adenine dinucleotide phosphate oxidase provides an example of deliberate reactive oxygen species generation, but the function of ..
  84. Potje S, Troiano J, Graton M, Ximenes V, Nakamune A, Antoniali C. Hypotensive and vasorelaxant effect of Diapocynin in normotensive rats. Free Radic Biol Med. 2017;106:148-157 pubmed publisher
    b>Nicotinamide adenine dinucleotide phosphate oxidase (NAD(P)H-oxidase) is a multicomponent enzyme system that generates superoxide anion by one-electron reduction of molecular oxygen and represents the major source of reactive oxygen ..
  85. Yu B, Liu Z, Fu Y, Wang Y, Zhang L, Cai Z, et al. CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling. Arterioscler Thromb Vasc Biol. 2017;37:1698-1709 pubmed publisher
    ..We further asked whether CYLD mediates AF activation via the regulation of nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) as it is an essential factor during AF transdifferentiation...
  86. Hernandez Saavedra D, Swain K, Tuder R, Petersen S, Nozik Grayck E. Redox Regulation of the Superoxide Dismutases SOD3 and SOD2 in the Pulmonary Circulation. Adv Exp Med Biol. 2017;967:57-70 pubmed publisher
    ..pulmonary circulation, these sources include the mitochondrial electron transport chain, NADPH oxidases (NOX1-4, Duox1,2), nitric oxide synthases, and xanthine oxidase; this important topic has been thoroughly reviewed recently [1]...
  87. Hirakawa S, Saito R, Ohara H, Okuyama R, Aiba S. Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes. J Immunol. 2011;186:4762-70 pubmed publisher
    ..However, the expression of DUOX1 or DUOX2 has not yet been examined in keratinocytes...
  88. Pacquelet S, Lehmann M, Luxen S, Regazzoni K, Frausto M, Noack D, et al. Inhibitory action of NoxA1 on dual oxidase activity in airway cells. J Biol Chem. 2008;283:24649-58 pubmed publisher
    ..A functional Duox1-based oxidase was reconstituted in model cell lines to permit mutational analysis of Noxa1 and Duox1...
  89. Hristova M, Veith C, Habibovic A, Lam Y, Deng B, Geiszt M, et al. Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells. Redox Biol. 2014;2:436-46 pubmed publisher
    The NADPH oxidase homolog dual oxidase 1 (DUOX1) plays an important role in innate airway epithelial responses to infection or injury, but the precise molecular mechanisms are incompletely understood and the cellular redox-sensitive ..
  90. Chen S, Yu K, Ling Q, Huang C, Li N, Zheng J, et al. The combination of three molecular markers can be a valuable predictive tool for the prognosis of hepatocellular carcinoma patients. Sci Rep. 2016;6:24582 pubmed publisher
    ..Cox multivariate regression analysis demonstrated that DUOX1, GLS2, FBP1 and age were independent risk factors for the prognosis of HCC patients after surgery...
  91. Choi H, Park J, Kim H, Noh M, Ueyama T, Bae Y, et al. Hydrogen peroxide generated by DUOX1 regulates the expression levels of specific differentiation markers in normal human keratinocytes. J Dermatol Sci. 2014;74:56-63 pubmed publisher
    ..in normal human keratinocytes (NHKs), and elucidate the physiological role of H2O2 generated by identified dual oxidase 1 (DUOX1) on differentiation markers of NHKs...
  92. Tang H, Pang S. Proline Catabolism Modulates Innate Immunity in Caenorhabditis elegans. Cell Rep. 2016;17:2837-2844 pubmed publisher
    ..Intriguingly, proline catabolism-mediated activation of SKN-1 requires cell-membrane dual-oxidase Ce-Duox1/BLI-3, highlighting the importance of interaction between mitochondrial and cell-membrane components in host ..