DTNBP1

Summary

Gene Symbol: DTNBP1
Description: dystrobrevin binding protein 1
Alias: BLOC1S8, DBND, HPS7, My031, SDY, dysbindin, BLOC-1 subunit 8, Hermansky-Pudlak syndrome 7 protein, biogenesis of lysosomal organelles complex-1, subunit 8, biogenesis of lysosome-related organelles complex 1 subunit 8, dysbindin-1
Species: human
Products:     DTNBP1

Top Publications

  1. Tochigi M, Zhang X, Ohashi J, Hibino H, Otowa T, Rogers M, et al. Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population. Neurosci Res. 2006;56:154-8 pubmed
    b>Dysbindin (DTNBP1: dystrobrevin binding protein 1), located on 6p22.3, is a candidate susceptibility gene for schizophrenia...
  2. Vilella E, Costas J, Sanjuan J, Guitart M, de Diego Y, Carracedo A, et al. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. J Psychiatr Res. 2008;42:278-88 pubmed
    ..In summary, these results may provide further support for an association between the dysbindin gene (DTNBP1) and schizophrenia, but not between the disease and DAO, DAOA, NRG1 and RGS4 or with the ..
  3. Markov V, Krug A, Krach S, Whitney C, Eggermann T, Zerres K, et al. Genetic variation in schizophrenia-risk-gene dysbindin 1 modulates brain activation in anterior cingulate cortex and right temporal gyrus during language production in healthy individuals. Neuroimage. 2009;47:2016-22 pubmed publisher
    Genetic variation in dysbindin 1 (DTNBP1) gene region tagged by SNP rs1018381 exhibits a linkage with cognitive deficits in patients with schizophrenia and healthy subjects...
  4. Wolf C, Jackson M, Kissling C, Thome J, Linden D. Dysbindin-1 genotype effects on emotional working memory. Mol Psychiatry. 2011;16:145-55 pubmed publisher
    We combined functional imaging and genetics to investigate the behavioral and neural effects of a dysbindin-1 (DTNBP1) genotype associated with the expression level of this important synaptic protein, which has been implicated in ..
  5. Fallgatter A, Herrmann M, Hohoff C, Ehlis A, Jarczok T, Freitag C, et al. DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in healthy individuals. Neuropsychopharmacology. 2006;31:2002-10 pubmed
    DTNBP1 (dysbindin) is one of the several putative schizophrenia genes supported by association, neuroanatomical, and cellular studies...
  6. Maier W. Common risk genes for affective and schizophrenic psychoses. Eur Arch Psychiatry Clin Neurosci. 2008;258 Suppl 2:37-40 pubmed publisher
    ..The reasons are a series of cross-diagnostic molecular-genetic discoveries: specific alleles in the genes for dysbindin (DTNBP1), neuregulin (NRG1) and DAOA (G72/G30) reveal associations for each of both groups of disorders in the ..
  7. Morris D, McGhee K, Schwaiger S, Scully P, Quinn J, Meagher D, et al. No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study. Schizophr Res. 2003;60:167-72 pubmed
    ..association study identified a putative association between variants in the dystrobrevin binding protein 1 (dysbindin) gene (DTNBP1) and schizophrenia...
  8. Burdick K, Lencz T, Funke B, Finn C, Szeszko P, Kane J, et al. Genetic variation in DTNBP1 influences general cognitive ability. Hum Mol Genet. 2006;15:1563-8 pubmed
    ..The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder ..
  9. Mechelli A, Viding E, Kumar A, Pettersson Yeo W, Fusar Poli P, Tognin S, et al. Dysbindin modulates brain function during visual processing in children. Neuroimage. 2010;49:817-22 pubmed publisher
    ..Several genetic studies have identified dystrobrevin binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain function is poorly understood...

More Information

Publications78

  1. Tosato S, Ruggeri M, Bonetto C, Bertani M, Marrella G, Lasalvia A, et al. Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:647-59 pubmed
    There is evidence suggesting that Dysbindin (DTNBP1) is a susceptibility gene for schizophrenia in Caucasian, Chinese, and Japanese populations...
  2. Joo E, Lee K, Jeong S, Chang J, Ahn Y, Koo Y, et al. Dysbindin gene variants are associated with bipolar I disorder in a Korean population. Neurosci Lett. 2007;418:272-5 pubmed
    The dysbindin gene (DTNBP1) has been associated with schizophrenia in several populations...
  3. Luciano M, Miyajima F, Lind P, Bates T, Horan M, Harris S, et al. Variation in the dysbindin gene and normal cognitive function in three independent population samples. Genes Brain Behav. 2009;8:218-27 pubmed publisher
    ..Our results therefore support involvement of the dysbindin gene in cognitive function, but further work is needed to clarify the specific functional variants involved and ..
  4. Kirov G, Ivanov D, Williams N, Preece A, Nikolov I, Milev R, et al. Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biol Psychiatry. 2004;55:971-5 pubmed
    The gene encoding the dystrobrevin binding protein (DTNBP1) has been implicated in the pathogenesis of schizophrenia by several association studies...
  5. Bray N, Preece A, Williams N, Moskvina V, Buckland P, Owen M, et al. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Hum Mol Genet. 2005;14:1947-54 pubmed
    The DTNBP1 gene, encoding dysbindin, is now generally considered to be a susceptibility gene for schizophrenia...
  6. Williams N, Preece A, Morris D, Spurlock G, Bray N, Stephens M, et al. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Arch Gen Psychiatry. 2004;61:336-44 pubmed
    Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been identified in more than 1 study...
  7. Stefanis N, Trikalinos T, Avramopoulos D, Smyrnis N, Evdokimidis I, Ntzani E, et al. Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level. Biol Psychiatry. 2007;62:784-92 pubmed
    ..We examined the potential impact of 18 single nucleotide polymorphisms (SNPs) within the DTNBP1, NRG1, DAOA/G32, and DAAO genes, on cognition and self-rated schizotypy, in a representative population of 2243 ..
  8. Kircher T, Markov V, Krug A, Eggermann T, Zerres K, Nöthen M, et al. Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects. Psychol Med. 2009;39:1657-65 pubmed publisher
    ..The dystrobrevin-binding protein 1 (DTNBP1) gene located at chromosome 6p22.3 is one of the most often replicated vulnerability genes for schizophrenia...
  9. Talbot K, Cho D, Ong W, Benson M, Han L, Kazi H, et al. Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin. Hum Mol Genet. 2006;15:3041-54 pubmed
    Variations in the gene encoding the novel protein dysbindin-1 (DTNBP1) are among the most commonly reported genetic variations associated with schizophrenia...
  10. Kohn Y, Danilovich E, Filon D, Oppenheim A, Karni O, Kanyas K, et al. Linkage disequlibrium in the DTNBP1 (dysbindin) gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel: findings from identity by descent haplotype sharing analysis. Am J Med Genet B Neuropsychiatr Genet. 2004;128B:65-70 pubmed
    ..One was for psychotic patients with any diagnosis at the location of dysbindin, a gene previously associated with schizophrenia...
  11. Strohmaier J, Frank J, Wendland J, Schumacher J, Jamra R, Treutlein J, et al. A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry. Schizophr Res. 2010;118:98-105 pubmed publisher
    b>Dysbindin (DTNBP1) is a widely studied candidate gene for schizophrenia (SCZ); however, inconsistent results across studies triggered skepticism towards the validity of the findings...
  12. Mutsuddi M, Morris D, Waggoner S, Daly M, Scolnick E, Sklar P. Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia. Am J Hum Genet. 2006;79:903-9 pubmed
    b>DTNBP1 was first identified as a putative schizophrenia-susceptibility gene in Irish pedigrees, with a report of association to common genetic variation...
  13. Wessman J, Paunio T, Tuulio Henriksson A, Koivisto M, Partonen T, Suvisaari J, et al. Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia. Biol Psychiatry. 2009;66:990-6 pubmed publisher
    While DTNBP1, DISC1, and NRG1 have been extensively studied as candidate genes of schizophrenia, results remain inconclusive...
  14. Weickert C, Rothmond D, Hyde T, Kleinman J, Straub R. Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Schizophr Res. 2008;98:105-10 pubmed
    Genetic and molecular studies indicate that dysbindin-1 plays a role in the pathophysiology of schizophrenia...
  15. Voisey J, Swagell C, Hughes I, Lawford B, Young R, Morris C. Analysis of HapMap tag-SNPs in dysbindin (DTNBP1) reveals evidence of consistent association with schizophrenia. Eur Psychiatry. 2010;25:314-9 pubmed publisher
    Dystrobrevin binding protein 1 (DTNBP1), or dysbindin, is thought to be critical in regulating the glutamatergic system...
  16. Schwab S, Knapp M, Mondabon S, Hallmayer J, Borrmann Hassenbach M, Albus M, et al. Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am J Hum Genet. 2003;72:185-90 pubmed
    Genetic variants in a gene on 6p22.3, dysbindin, have been shown recently to be associated with schizophrenia (Straub et al. 2002a)...
  17. Nazarian R, Starcevic M, Spencer M, Dell Angelica E. Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein. Biochem J. 2006;395:587-98 pubmed
    b>Dysbindin was identified as a dystrobrevin-binding protein potentially involved in the pathogenesis of muscular dystrophy...
  18. Thimm M, Krug A, Kellermann T, Markov V, Krach S, Jansen A, et al. The effects of a DTNBP1 gene variant on attention networks: an fMRI study. Behav Brain Funct. 2010;6:54 pubmed publisher
    ..event-related fMRI study investigated the effect of the single nucleotide polymorphism (SNP) rs1018381 of the DTNBP1 (dystrobrevin-binding protein 1) gene on brain activity in 80 subjects while performing the attention network test ..
  19. Pae C, Drago A, Kim J, Patkar A, Jun T, Lee C, et al. DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients. Neurosci Lett. 2008;440:150-4 pubmed publisher
    b>Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required...
  20. Gaysina D, Cohen Woods S, Chow P, Martucci L, Schosser A, Ball H, et al. Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS). Am J Med Genet B Neuropsychiatr Genet. 2009;150B:836-44 pubmed publisher
    ..There is some evidence for an association of the dystrobrevin binding protein 1 gene (DTNBP1) with schizophrenia, and, thus, this gene has also become a focus of further investigation in bipolar disorder (BD)..
  21. Talbot K, Louneva N, Cohen J, Kazi H, Blake D, Arnold S. Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location. PLoS ONE. 2011;6:e16886 pubmed publisher
    ..DTNBP1 encodes dysbindin-1, reduced levels of which have been found in synaptic fields of schizophrenia cases...
  22. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, et al. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet. 2004;13:2699-708 pubmed
    Genetic variation in dysbindin (DTNBP1: dystrobrevin-binding protein 1) has recently been shown to be associated with schizophrenia. The dysbindin gene is located at chromosome 6p22...
  23. Duan J, Martinez M, Sanders A, Hou C, Burrell G, Krasner A, et al. DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene. Hum Hered. 2007;64:97-106 pubmed
    b>Dysbindin (DTNBP1) has been identified as a susceptibility gene for schizophrenia (SZ) through a positional approach...
  24. Benson M, Newey S, Martin Rendon E, Hawkes R, Blake D. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J Biol Chem. 2001;276:24232-41 pubmed
    ..Here we describe the identification of a dysbindin, a novel dystrobrevin-binding protein...
  25. Mullin A, Gokhale A, Larimore J, Faundez V. Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene. Mol Neurobiol. 2011;44:53-64 pubmed publisher
    There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia...
  26. Owen M, Williams N, O Donovan M. Dysbindin-1 and schizophrenia: from genetics to neuropathology. J Clin Invest. 2004;113:1255-7 pubmed
    The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al...
  27. Ciciotte S, Gwynn B, Moriyama K, Huizing M, Gahl W, Bonifacino J, et al. Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1). Blood. 2003;101:4402-7 pubmed
  28. Hall D, Gogos J, Karayiorgou M. The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations. Genes Brain Behav. 2004;3:240-8 pubmed
    ..strong candidate schizophrenia susceptibility genes; G72, neuregulin 1 (NRG1) and dystrobrevin-binding protein 1 (DTNBP1) in two independent datasets of patients with distinct genetic backgrounds...
  29. Kishimoto M, Ujike H, Motohashi Y, Tanaka Y, Okahisa Y, Kotaka T, et al. The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis. Biol Psychiatry. 2008;63:191-6 pubmed
    The dysbindin (DTNBP1 [dystrobrevin-binding protein 1]) gene has repeatedly been shown to be associated with schizophrenia across diverse populations...
  30. Thimm M, Krug A, Markov V, Krach S, Jansen A, Zerres K, et al. The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval. Hum Brain Mapp. 2010;31:203-9 pubmed publisher
    ..the effect of the single nucleotide polymorphism (SNP) rs1018381 (P1578) of the dystrobrevin-binding protein 1 (DTNBP1) on brain activity in 84 healthy subjects assessed by functional magnetic resonance imaging (fMRI) while they ..
  31. Donohoe G, Morris D, De Sanctis P, Magno E, Montesi J, Garavan H, et al. Early visual processing deficits in dysbindin-associated schizophrenia. Biol Psychiatry. 2008;63:484-9 pubmed
    Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing...
  32. Starcevic M, Dell Angelica E. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem. 2004;279:28393-401 pubmed
    ..The complex is known to contain the coiled-coil-forming proteins, Pallidin, Muted, Cappuccino, and Dysbindin. The genes encoding these proteins are defective in inbred mouse strains that serve as models of Hermansky-..
  33. Wirgenes K, Djurovic S, Agartz I, Jonsson E, Werge T, Melle I, et al. Dysbindin and d-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia. Neuropsychobiology. 2009;60:31-6 pubmed publisher
    ..Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both involved in glutamate receptor function, reported associations with ..
  34. Li D, He L. Association study between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia: a meta-analysis. Schizophr Res. 2007;96:112-8 pubmed
    Positional, functional and association studies have strongly implicated the dystrobrevin binding protein 1 gene (DTNBP1) as a promising novel candidate gene for schizophrenia...
  35. Fatjó Vilas M, Papiol S, Estrada G, Bombin I, Peralta V, Rosa A, et al. Dysbindin-1 gene contributes differentially to early- and adult-onset forms of functional psychosis. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:322-33 pubmed publisher
    b>Dysbindin-1 is a relatively ubiquitous protein in the brain which is involved in the modulation of synaptic homeostasis. The dysbindin-1 gene (DTNBP1) has been associated with schizophrenia and bipolar disorder diagnoses...
  36. Straub R, Jiang Y, MacLean C, Ma Y, Webb B, Myakishev M, et al. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet. 2002;71:337-48 pubmed
    ..this region, single-nucleotide polymorphisms within the 140-kb gene DTNBP1 (dystrobrevin-binding protein 1, or dysbindin) are strongly associated with schizophrenia...
  37. Marley A, von Zastrow M. Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes. PLoS ONE. 2010;5:e9325 pubmed publisher
    b>Dysbindin, a cytoplasmic protein long known to function in the biogenesis of specialized lysosome-related organelles (LROs), has been reported to reduce surface expression of D2 dopamine receptors in neurons...
  38. Pae C, Mandelli L, De Ronchi D, Kim J, Jun T, Patkar A, et al. Dysbindin gene (DTNBP1) and schizophrenia in Korean population. Eur Arch Psychiatry Clin Neurosci. 2009;259:137-42 pubmed publisher
    b>Dysbindin gene (DTNBP1) has been consistently reported to be associated with schizophrenia. However data from East Asian population has been sparse and inconsistent till today...
  39. Turunen J, Peltonen J, Pietiläinen O, Hennah W, Loukola A, Paunio T, et al. The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland. Schizophr Res. 2007;91:27-36 pubmed
    ..Significant associations between schizophrenia and neuregulin 1 (NRG1) and dysbindin (DTNBP1) were first reported in 2002 and studies in several populations have since independently reported ..
  40. Donohoe G, Morris D, Clarke S, McGhee K, Schwaiger S, Nangle J, et al. Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study. Neuropsychologia. 2007;45:454-8 pubmed
    ..We investigated the association between genotype and cognitive performance for a Dysbindin risk haplotype which is associated with schizophrenia in our sample...
  41. Nickl Jockschat T, Stöcker T, Markov V, Krug A, Huang R, Schneider F, et al. The impact of a Dysbindin schizophrenia susceptibility variant on fiber tract integrity in healthy individuals: a TBSS-based diffusion tensor imaging study. Neuroimage. 2012;60:847-53 pubmed publisher
    ..We here present a study on the effects of a Dysbindin schizophrenia susceptibility gene variant on fiber tract integrity in healthy young subjects...
  42. DeRosse P, Funke B, Burdick K, Lencz T, Ekholm J, Kane J, et al. Dysbindin genotype and negative symptoms in schizophrenia. Am J Psychiatry. 2006;163:532-4 pubmed
    Converging evidence has demonstrated an association between variants in the dysbindin gene (DTNBP1) and schizophrenia...
  43. Li W, Zhang Q, Oiso N, Novak E, Gautam R, O Brien E, et al. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet. 2003;35:84-9 pubmed
    ..7). Here we show that the sdy mutant mouse expresses no dysbindin protein owing to a deletion in the gene Dtnbp1 (encoding dysbindin) and that mutation of the human ortholog ..
  44. Ma X, Fei E, Fu C, Ren H, Wang G. Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol Psychiatry. 2011;16:1105-16 pubmed publisher
    Genetic variations in the DTNBP1 gene (encoding the protein dysbindin-1) have been implicated as risk factors in the pathogenesis of schizophrenia...
  45. Maher B, Reimers M, Riley B, Kendler K. Allelic heterogeneity in genetic association meta-analysis: an application to DTNBP1 and schizophrenia. Hum Hered. 2010;69:71-9 pubmed publisher
    ..We then apply these methods to the association between DTNBP1 and schizophrenia (Scz), one of the most studied relationships in complex disease genetics...
  46. van den Oord E, Sullivan P, Jiang Y, Walsh D, O Neill F, Kendler K, et al. Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families. Mol Psychiatry. 2003;8:499-510 pubmed
    ..1). The cluster was identified as the human dystrobrevin binding protein 1 gene (DTNBP1) by sequence database comparisons and homology with mouse DTNBP1. (2)...
  47. Locke M, Tinsley C, Benson M, Blake D. TRIM32 is an E3 ubiquitin ligase for dysbindin. Hum Mol Genet. 2009;18:2344-58 pubmed publisher
    ..Using the yeast two-hybrid system, we found that TRIM32 binds and ubiquitinates dysbindin, a protein implicated in the genetic aetiology of schizophrenia, augmenting its degradation...
  48. Liu C, Liu Y, Fann C, Yang W, Wu J, Hung S, et al. No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families. Schizophr Res. 2007;93:391-8 pubmed
    ..to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 (DTNBP1)...
  49. Pae C, Serretti A, Mandelli L, Yu H, Patkar A, Lee C, et al. Effect of 5-haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:701-3 pubmed
    We investigated a possible association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID)...
  50. Van Den Bogaert A, Schumacher J, Schulze T, Otte A, Ohlraun S, Kovalenko S, et al. The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease. Am J Hum Genet. 2003;73:1438-43 pubmed
    We have investigated the gene for dystrobrevin-binding protein 1 (DTNBP1), or dysbindin, which has been strongly suggested as a positional candidate gene for schizophrenia, in three samples of subjects with schizophrenia and unaffected ..
  51. Funke B, Finn C, Plocik A, Lake S, DeRosse P, Kane J, et al. Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet. 2004;75:891-8 pubmed
    Linkage and association studies have recently implicated dystrobrevin-binding protein 1 (DTNBP1) in the etiology of schizophrenia...
  52. Gornick M, Addington A, Sporn A, Gogtay N, Greenstein D, Lenane M, et al. Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS). J Autism Dev Disord. 2005;35:831-8 pubmed
    Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13...
  53. Breen G, Prata D, Osborne S, Munro J, Sinclair M, Li T, et al. Association of the dysbindin gene with bipolar affective disorder. Am J Psychiatry. 2006;163:1636-8 pubmed
    ..The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and ..
  54. Tang J, LeGros R, Louneva N, Yeh L, Cohen J, Hahn C, et al. Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression. Hum Mol Genet. 2009;18:3851-63 pubmed publisher
    ..Reduced expression of this gene and of its encoded protein, dysbindin-1, have been reported in the brains of schizophrenia cases...
  55. Markov V, Krug A, Krach S, Jansen A, Eggermann T, Zerres K, et al. Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals. Hum Brain Mapp. 2010;31:266-75 pubmed publisher
    ..A strong linkage between genetic variants in the dysbindin 1 gene and schizophrenia has been demonstrated...
  56. Joo E, Lee K, Jeong S, Ahn Y, Koo Y, Kim Y. The dysbindin gene (DTNBP1) and schizophrenia: no support for an association in the Korean population. Neurosci Lett. 2006;407:101-6 pubmed
    The dysbindin gene (DTNBP1) is located in chromosome 6p22.3, one of the regions of positive linkage for schizophrenia. A strong genetic association between DTNBP1 and schizophrenia has been replicated through many recent studies...
  57. Di Pietro S, Falcon Perez J, Tenza D, Setty S, Marks M, Raposo G, et al. BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol Biol Cell. 2006;17:4027-38 pubmed
    ..These findings support the idea that BLOC-1 and -2 represent hitherto unknown components of the endosomal protein trafficking machinery. ..
  58. Zuo L, Luo X, Kranzler H, Lu L, Rosenheck R, Cramer J, et al. Association study of DTNBP1 with schizophrenia in a US sample. Psychiatr Genet. 2009;19:292-304 pubmed
    ..this original finding, but the reported findings are highly diverse and at least five pathways by which dysbindin protein might be involved in schizophrenia have been proposed...
  59. Talbot K, Eidem W, Tinsley C, Benson M, Thompson E, Smith R, et al. Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J Clin Invest. 2004;113:1353-63 pubmed
    ..between schizophrenia and certain haplotypes of single-nucleotide polymorphisms in the gene encoding dysbindin-1 at 6p22.3...
  60. Tang J, Zhou J, Fan J, Li X, Shi Y, Gu N, et al. Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. Mol Psychiatry. 2003;8:717-8 pubmed
  61. Zill P, Baghai T, Engel R, Zwanzger P, Schule C, Eser D, et al. The dysbindin gene in major depression: an association study. Am J Med Genet B Neuropsychiatr Genet. 2004;129B:55-8 pubmed
    ..In this context, the dysbindin gene (dystrobrevin-binding-protein 1, DTNBP1), which was recently reported to be associated with schizophrenia ..
  62. Sanders A, Duan J, Levinson D, Shi J, He D, Hou C, et al. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry. 2008;165:497-506 pubmed publisher
    The authors carried out a genetic association study of 14 schizophrenia candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, and ARVCF)...
  63. Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Suzuki T, Iwata N, et al. A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. World J Biol Psychiatry. 2010;11:431-8 pubmed publisher
    ..A genetic variation in the dysbindin gene (DTNBP1: dystrobrevin binding protein 1), a susceptibility gene for schizophrenia, has been reported to be ..
  64. Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, et al. Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects. Psychiatry Clin Neurosci. 2009;63:550-6 pubmed publisher
    The dysbindin gene (dystrobrevin binding protein 1: DTNBP1) is a susceptibility gene for schizophrenia...
  65. Li T, Zhang F, Liu X, Sun X, Sham P, Crombie C, et al. Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations. Mol Psychiatry. 2005;10:1037-44 pubmed
    The dystrobrevin-binding protein 1 (DTNBP1) gene on chromosome 6p has emerged as a potential susceptibility gene for schizophrenia...
  66. Burdick K, Goldberg T, Funke B, Bates J, Lencz T, Kucherlapati R, et al. DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophr Res. 2007;89:169-72 pubmed
    ..current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1)...
  67. Raybould R, Green E, Macgregor S, Gordon Smith K, Heron J, Hyde S, et al. Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biol Psychiatry. 2005;57:696-701 pubmed
    Several studies support the dysbindin (dystrobrevin binding protein 1) gene (DTNBP1) as a susceptibility gene for schizophrenia...
  68. Zinkstok J, de Wilde O, van Amelsvoort T, Tanck M, Baas F, Linszen D. Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings. Behav Brain Funct. 2007;3:19 pubmed
    The dystrobrevin-binding protein 1 (DTNBP1) gene is a susceptibility gene for schizophrenia. There is growing evidence that DTNPB1 contributes to intelligence and cognition...
  69. Iizuka Y, Sei Y, Weinberger D, Straub R. Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization. J Neurosci. 2007;27:12390-5 pubmed
    The schizophrenia susceptibility gene dystrobrevin-binding protein 1 (DTNBP1) encodes dysbindin, which along with its binding partner Muted is an essential component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)...