Gene Symbol: DTNA
Description: dystrobrevin alpha
Alias: D18S892E, DRP3, DTN, DTN-A, LVNC1, dystrobrevin alpha, dystrophin-related protein 3
Species: human
Products:     DTNA

Top Publications

  1. Ahn A, Kunkel L. Syntrophin binds to an alternatively spliced exon of dystrophin. J Cell Biol. 1995;128:363-71 pubmed
  2. Sadoulet Puccio H, Khurana T, Cohen J, Kunkel L. Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane. Hum Mol Genet. 1996;5:489-96 pubmed
    ..In addition, antibodies against either the Torpedo 87 kDa protein or human dystrobrevin demonstrate that at least three of the splice forms are translated as proteins in human brain tissue extracts. ..
  3. Ambrose H, Blake D, Nawrotzki R, Davies K. Genomic organization of the mouse dystrobrevin gene: comparative analysis with the dystrophin gene. Genomics. 1997;39:359-69 pubmed
    ..Interestingly, although there is only 27% amino acid identity between the homologous regions of dystrobrevin and dystrophin, the positions of 8 of the 15 exon-intron junctions are identical. ..
  4. Blake D, Nawrotzki R, Loh N, Gorecki D, Davies K. beta-dystrobrevin, a member of the dystrophin-related protein family. Proc Natl Acad Sci U S A. 1998;95:241-6 pubmed
    ..This finding may be relevant to the cognitive dysfunction affecting many patients with Duchenne muscular dystrophy. ..
  5. Ichida F, Tsubata S, Bowles K, Haneda N, Uese K, Miyawaki T, et al. Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. Circulation. 2001;103:1256-63 pubmed
    ..In addition, these results confirm that mutations in G4.5 result in a wide phenotypic spectrum of cardiomyopathies. ..
  6. Mizuno Y, Thompson T, Guyon J, Lidov H, Brosius M, Imamura M, et al. Desmuslin, an intermediate filament protein that interacts with alpha -dystrobrevin and desmin. Proc Natl Acad Sci U S A. 2001;98:6156-61 pubmed
    ..Our findings suggest that DMN may serve as a direct linkage between the extracellular matrix and the Z-discs (through plectin) and may play an important role in maintaining muscle cell integrity. ..
  7. Sadoulet Puccio H, Rajala M, Kunkel L. Dystrobrevin and dystrophin: an interaction through coiled-coil motifs. Proc Natl Acad Sci U S A. 1997;94:12413-8 pubmed
    ..From the accumulated evidence of protein-protein interactions presented here and elsewhere, we propose a partially revised model of the organization of the dystrophin-associated glycoprotein complex. ..
  8. Nawrotzki R, Loh N, Ruegg M, Davies K, Blake D. Characterisation of alpha-dystrobrevin in muscle. J Cell Sci. 1998;111 ( Pt 17):2595-605 pubmed
  9. Piluso G, Mirabella M, Ricci E, Belsito A, Abbondanza C, Servidei S, et al. Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. J Biol Chem. 2000;275:15851-60 pubmed
    ..Our present findings suggest a differentiated role of a modified dystrophin-associated complex in the central nervous system. ..

More Information

Publications115 found, 100 shown here

  1. Blake D, Nawrotzki R, Peters M, Froehner S, Davies K. Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic protein. J Biol Chem. 1996;271:7802-10 pubmed
    ..The occurrence of many dystrobrevin isoforms is significant because alternative splicing and phosphorylation often have profound effects upon the biological activity of synaptic proteins. ..
  2. Blake D, Hawkes R, Benson M, Beesley P. Different dystrophin-like complexes are expressed in neurons and glia. J Cell Biol. 1999;147:645-58 pubmed
    ..Thus, despite the similarity in primary sequence, alpha- and beta-dystrobrevin are differentially distributed in the brain where they form separate DPC-like complexes. ..
  3. Newey S, Benson M, Ponting C, Davies K, Blake D. Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. Curr Biol. 2000;10:1295-8 pubmed
    ..This is likely to have important consequences for the recruitment of specific signalling molecules to the DPC and ultimately for its function. ..
  4. Yoshida M, Hama H, Ishikawa Sakurai M, Imamura M, Mizuno Y, Araishi K, et al. Biochemical evidence for association of dystrobrevin with the sarcoglycan-sarcospan complex as a basis for understanding sarcoglycanopathy. Hum Mol Genet. 2000;9:1033-40 pubmed
    ..It is thus considered that the sarcoglycan-sarcospan complex is linked to the signaling protein neuronal nitric oxide synthase via alpha-syntrophin associated with dystrobrevin. ..
  5. Newey S, Howman E, Ponting C, Benson M, Nawrotzki R, Loh N, et al. Syncoilin, a novel member of the intermediate filament superfamily that interacts with alpha-dystrobrevin in skeletal muscle. J Biol Chem. 2001;276:6645-55 pubmed
  6. Benson M, Newey S, Martin Rendon E, Hawkes R, Blake D. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J Biol Chem. 2001;276:24232-41 pubmed
    ..These findings have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane. ..
  7. He Z, Zhang J, Shi Z, Liu J, Zhang J, Yan Z, et al. Modification of contact avoidance behaviour associated with pyrethroid resistance in Anopheles sinensis (Diptera: Culicidae). Malar J. 2019;18:131 pubmed publisher
    ..mosquitoes exhibited significantly longer flying time and more takeoffs on deltamethrin-treated bed nets (DTN) than on untreated bed nets (UTN), suggestive of robust avoidance behaviour...
  8. Kayvanpour E, Sedaghat Hamedani F, Gi W, Tugrul O, Amr A, Haas J, et al. Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals. Clin Res Cardiol. 2019;: pubmed publisher
    ..TPM1, MIB1, ACTC1, and LMNA mutations had an average frequency of 2% each. Mutations in PLN, HCN4, TAZ, DTNA, TNNT2, and RBM20 were reported with a frequency of 1% each...
  9. Rasmussen M, Fabricius Bjerre A, Kumarathurai P, Larsen B, Dominguez H, Kanters J, et al. Common source of miscalculation and misclassification of P-wave negativity and P-wave terminal force in lead V1. J Electrocardiol. 2019;53:85-88 pubmed publisher
    P-wave terminal force (PTF) > 4000 ms·μV and deep terminal negativity (DTN) are ECG markers of left atrial abnormality associated with both atrial fibrillation and stroke...
  10. La G, Zhou M, Lim J, Oh S, Xing H, Liu N, et al. Proteomics and Transcriptomics Analysis Reveals Clues into the Mechanism of the Beneficial Effect of Electrical Stimulation on Rat Denervated Gastrocnemius Muscle. Cell Physiol Biochem. 2019;52:769-786 pubmed publisher
    ..MYOM2), M-line structural protein (MYOM2), dystrophin combined with glycoprotein complex proteins (SGCB, SGCD, and DTNA), and anti-fibrosis-related proteins (POSTN, COL1A1, COL1A2, COL6A1, COL6A2, COL6A3, FN1, and LUM), may be related ..
  11. Saito M, Onodera S, Okubo K, Takagi S, Maruyama Y, Jin G, et al. Effects of physical and morphometric factors on nutrient removal properties in agricultural ponds. Water Sci Technol. 2015;72:2187-93 pubmed publisher
    ..5 m) and influenced by the thermal stratification. Removal ratios of dissolved total nitrogen (DTN) and dissolved total phosphorus in the ponds were estimated to be 53-98% and 39-98% in August and 10-92% and 36-57% ..
  12. Bujari A, Calafate C, Cano J, Manzoni P, Palazzi C, Ronzani D. A Location-Aware Waypoint-Based Routing Protocol for Airborne DTNs in Search and Rescue Scenarios. Sensors (Basel). 2018;18: pubmed publisher
    ..Simulation results show that the proposed solution outperforms the classic DTN routing protocols in terms of several performance metrics.
  13. Zhang Z, Ma M, Jin Z. CCS-DTN: clustering and network coding-based efficient routing in social DTNs. Sensors (Basel). 2014;15:285-303 pubmed publisher
    ..In our solution, the characteristics of nodes and the relation between nodes are fully considered. The simulation results show that our proposed scheme can significantly improve the performance of the routing scheme in social DTNs. ..
  14. Saleem M, Fetzer I, Harms H, Chatzinotas A. Trophic complexity in aqueous systems: bacterial species richness and protistan predation regulate dissolved organic carbon and dissolved total nitrogen removal. Proc Biol Sci. 2016;283:20152724 pubmed publisher
    Loading of water bodies with dissolved organic carbon (DOC) and dissolved total nitrogen (DTN) affects their integrity and functioning. Microbial interactions mitigate the negative effects of high nutrient loads in these ecosystems...
  15. Mao Y, Zhou C, Ling Y, Lloret J. An Optimized Probabilistic Delay Tolerant Network (DTN) Routing Protocol Based on Scheduling Mechanism for Internet of Things (IoT). Sensors (Basel). 2019;19: pubmed publisher
    ..Things (IoT) have been implemented based on unreliable wireless or mobile networks like the delay tolerant network (DTN). Therefore, it is an important issue for IoT applications to achieve efficient data transmission in DTN...
  16. Gao Y, Yu J, Song Y, Zhu G, Paerl H, Qin B. Spatial and temporal distribution characteristics of different forms of inorganic nitrogen in three types of rivers around Lake Taihu, China. Environ Sci Pollut Res Int. 2019;26:6898-6910 pubmed publisher
    ..The results showed that dissolved total nitrogen (DTN) was the main fraction of total nitrogen (TN) input from these rivers...
  17. Chang S, Chung Davidson Y, Libants S, Nanlohy K, Kiupel M, Brown C, et al. The sea lamprey has a primordial accessory olfactory system. BMC Evol Biol. 2013;13:172 pubmed publisher
    ..Neural tract-tracing revealed direct and reciprocal connections with the dorsomedial telencephalic neuropil (DTN) which in turn projects directly to the dorsal pallium and the rostral hypothalamus...
  18. Gilbert B, Huffman J, Slechta J, Porter C, Gallagher J. Pharmacoeconomic impact of an alternative workflow process for stroke. Am J Emerg Med. 2019;37:294-297 pubmed publisher
    ..ischemic stroke (AIS), was salvaged in an attempt to maximize cost effectiveness without impacting door-to-needle (DTN) administration times. This was a retrospective cohort between May 2017 and February 2018...
  19. Mao R, Li S. Temporal controls on dissolved organic carbon biodegradation in subtropical rivers: Initial chemical composition versus stoichiometry. Sci Total Environ. 2019;651:3064-3069 pubmed publisher
    ..Here, we investigated the concentrations of DOC, dissolved total nitrogen (DTN), and dissolved total phosphorus (DTP), humification index (HIX), fluorescence index (FI), and DOC biodegradation ..
  20. Yang X, Smith A, Williams M, Pal U. A dityrosine network mediated by dual oxidase and peroxidase influences the persistence of Lyme disease pathogens within the vector. J Biol Chem. 2014;289:12813-22 pubmed publisher
    ..scapularis ticks. This dityrosine network (DTN) is dependent upon a dual oxidase (Duox), which is a member of the NADPH oxidase family...
  21. Hao Z, Gao Y, Yang T, Tian J. Atmospheric wet deposition of nitrogen in a subtropical watershed in China: characteristics of and impacts on surface water quality. Environ Sci Pollut Res Int. 2017;24:8489-8503 pubmed publisher
    ..72 kg N hm-2 year-1 and dissolved total nitrogen (DTN) was 23.18 kg N hm-2 year-1, respectively...
  22. Pepe F, De Luca F, Stracquadanio M, Garraffo C, Santonocito V, Privitera A. [Pregnancy after bariatric surgery]. Minerva Ginecol. 2017;69:195-205 pubmed publisher
    ..is at high risk of prematurity and fetal growth restriction, but they seem not at increased risk of birth defects (DTN) except in individual cases of folic acid deficiency (DTN) or vitamin K defect (similar abnormalities in patients ..
  23. Iglesias Mohedano A, García Pastor A, García Arratibel A, Sobrino García P, Díaz Otero F, Romero Delgado F, et al. Factors associated with in-hospital delays in treating acute stroke with intravenous thrombolysis in a tertiary centre. Neurologia. 2016;31:452-8 pubmed publisher
    This study aims to determine which factors are associated with delays in door-to needle (DTN) time in our hospital. This will help us design future strategies to shorten time to treatment with intravenous thrombolysis (IVT)...
  24. Wu D, Huang Y, Hu S, Yi X, Wang J. Sensitive Hg2+ Sensing via Quenching the Fluorescence of the Complex between Polythymine and 5,10,15,20-tetrakis(N-methyl-4-pyridyl) Porphyrin (TMPyP). Sensors (Basel). 2018;18: pubmed publisher
    The interaction between polythymine (dTn) and 5,10,15,20-tetrakis(N-methyl-4-pyridyl) porphyrin (TMPyP) was systematically studied using various techniques...
  25. Wuttke S, Schweinberger S. The P200 predominantly reflects distance-to-norm in face space whereas the N250 reflects activation of identity-specific representations of known faces. Biol Psychol. 2019;140:86-95 pubmed publisher
    ..Similarly, varying distance-to-norm (DTN, in absolute values) should have equivalent effects on typicality for both unfamiliar faces and their anti-faces...
  26. Dickson R, Sumathipala D, Reeves J. Stop Stroke© Acute Care Coordination Medical Application: A Brief Report on Postimplementation Performance at a Primary Stroke Center. J Stroke Cerebrovasc Dis. 2016;25:1275-1279 pubmed publisher
    ..of our study was to evaluate the effect of the Pulsara Stop Stroke© medical application on door-to-needle (DTN) time in patients presenting to our emergency department with acute ischemic stroke (AIS)...
  27. Steen M, Adams M, Tesch Y, Froehner S. Amelioration of muscular dystrophy by transgenic expression of Niemann-Pick C1. Mol Biol Cell. 2009;20:146-52 pubmed publisher
    ..By examining gene expression alterations in mouse skeletal muscle lacking alpha-dystrobrevin (Dtna(-/-)), we identified a highly significant reduction of the cholesterol trafficking protein, Niemann-Pick C1 (NPC1)...
  28. Shah S, Luby M, Poole K, Morella T, KELLER E, Benson R, et al. Screening with MRI for Accurate and Rapid Stroke Treatment: SMART. Neurology. 2015;84:2438-44 pubmed publisher
    ..Quality improvement processes were initiated in 2013 to reduce door-to-needle (DTN) time at the 2 hospitals where the NIH stroke team provides clinical care...
  29. Wöstmann B, Seelbach M, Seelbach P, Podhorsky A, Kolb G, Bretzel R, et al. Mini dental assessment: a simple screening test for non-dental staff. Clin Oral Investig. 2017;21:1457-1464 pubmed publisher
    The objective of this study was to develop a simple tool for the assessment of possible dental treatment needs (DTN) for non-dental professionals (Mini Dental Assessment, MDA)...
  30. Iglesias Mohedano A, García Pastor A, Diaz Otero F, Vázquez Alen P, Vales Montero M, Luque Buzo E, et al. Efficacy of New Measures Saving Time in Acute Stroke Management: A Quantified Analysis. J Stroke Cerebrovasc Dis. 2017;26:1817-1823 pubmed publisher
    ..management and assessed its repercussion on door-to-imaging (DTI), imaging-to-needle (ITN), and door-to-needle (DTN) times...
  31. Sousa D, Luis M, Sargento S, Pereira A. An Aquatic Mobile Sensing USV Swarm with a Link Quality-Based Delay Tolerant Network. Sensors (Basel). 2018;18: pubmed publisher
    ..mobile sensing platform for data gathering with a swarm of USVs communicating through a Delay-Tolerant Network (DTN)...
  32. Andas A, Abdul A, Rahman H, Sukari M, Abdelwahab S, Samad N, et al. Dentatin from Clausena excavata Induces Apoptosis in HepG2 Cells via Mitochondrial Mediated Signaling. Asian Pac J Cancer Prev. 2015;16:4311-6 pubmed
    ..In this investigation, the antiproliferative effects of dentatin (DTN), a natural coumarin, were evaluated on HepG2 cells and DTN's probable preliminary molecular mechanisms in ..
  33. Prabhakaran S, Lee J, O Neill K. Regional Learning Collaboratives Produce Rapid and Sustainable Improvements in Stroke Thrombolysis Times. Circ Cardiovasc Qual Outcomes. 2016;9:585-92 pubmed publisher
    Reduction in door-to-needle (DTN) times in patients with acute ischemic stroke treated with tissue-type plasminogen activator is associated with improved outcomes...
  34. Xian Y, Xu H, Lytle B, Blevins J, Peterson E, Hernandez A, et al. Use of Strategies to Improve Door-to-Needle Times With Tissue-Type Plasminogen Activator in Acute Ischemic Stroke in Clinical Practice: Findings from Target: Stroke. Circ Cardiovasc Qual Outcomes. 2017;10: pubmed publisher
    ..stage of the American Heart Association's national quality improvement initiative to accelerate door-to-needle (DTN) times, was associated with an average 15-minute reduction in DTN times...
  35. Zguira Y, Rivano H, Meddeb A. Internet of Bikes: A DTN Protocol with Data Aggregation for Urban Data Collection. Sensors (Basel). 2018;18: pubmed publisher
    ..In this paper, we propose an efficient, "Internet of Bikes", IoB-DTN routing protocol based on data aggregation which applies the Delay Tolerant Network (DTN) paradigm to Internet of ..
  36. Mowla A, Doyle J, Lail N, Rajabzadeh Oghaz H, Deline C, Shirani P, et al. Delays in door-to-needle time for acute ischemic stroke in the emergency department: A comprehensive stroke center experience. J Neurol Sci. 2017;376:102-105 pubmed publisher
    ..This study aimed to identify the delaying factors in door-to-needle time (DTN) in the emergency department of one of the largest comprehensive stroke centers in New York State...
  37. Simon M, Wang M, Murchison C, Roese N, Boespflug E, Woltjer R, et al. Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology. Sci Rep. 2018;8:12389 pubmed publisher
    ..data, we demonstrate that expression of perivascular astroglial gene products dystroglycan (DAG1), dystrobrevin (DTNA) and alpha-syntrophin (SNTA1), are associated with dementia status and phosphorylated tau (P-tau) levels in ..
  38. Zhang C, Min L, Liu J, Tian W, Han Y, Qu L, et al. Integrated analysis identified an intestinal-like and a diffuse-like gene sets that predict gastric cancer outcome. Tumour Biol. 2016;: pubmed
    ..Among genes overexpressed in diffuse subtype, DTNA, GPR161, IDS, RHOQ, and TSHZ2 were correlated with negative prognosis...
  39. Li N, Tang Y, Liu B, Cong W, Liu C, Xiao J. Retinoid acid-induced microRNA-27b-3p impairs C2C12 myoblast proliferation and differentiation by suppressing ?-dystrobrevin. Exp Cell Res. 2017;350:301-311 pubmed publisher
    ..up-regulated in RA-treated C2C12 cells as in embryonic tongue, and predicted to target the 3'UTR of ?-dystrobrevin (DTNA). Luciferase reporter assays confirmed the direct interaction between miR-27b-3p and the 3'UTR of DTNA...
  40. Hébant B, Triquenot Bagan A, Guegan Massardier E, Ozkul Wermester O, Maltete D. In-hospital delays to stroke thrombolysis: Out of hours versus regular hours and reduction in treatment times through the creation of a 24/7 mobile thrombolysis team. J Neurol Sci. 2018;392:46-50 pubmed publisher
    ..In 2013-2014, 133 patients were included. Both median door-to-needle (DTN) and imaging to needle (ITN) times were shorter for patients admitted during RH than OH, respectively 75 min ..
  41. Mausbach K, Velten J, Rehmann P, Kolb G, Wostmann B. [Development and validation of the Mini Dental Assessment : A procedure for improved estimation of need for dental treatment in geriatrics]. Z Gerontol Geriatr. 2018;: pubmed publisher
    ..was to develop and validate a simple tool (Mini Dental Assessment, MDA) to assess possible dental treatment needs (DTN) of residential geriatric facilities by nursing personnel...
  42. Velásquez Villada C, Donoso Y. Delay/Disruption Tolerant Network-Based Message Forwarding for a River Pollution Monitoring Wireless Sensor Network Application. Sensors (Basel). 2016;16:436 pubmed publisher
    ..For non-real-time applications, we propose a Delay/Disruption Tolerant Network (DTN)-based solution where all nodes have persistent storage capabilities and DTN protocols to be able to wait minutes ..
  43. Moran J, Nakagawa K, Asai S, Koenig M. 24/7 Neurocritical Care Nurse Practitioner Coverage Reduced Door-to-Needle Time in Stroke Patients Treated with Tissue Plasminogen Activator. J Stroke Cerebrovasc Dis. 2016;25:1148-1152 pubmed publisher
    ..24/7 ACNP stroke code coverage (intervention) was introduced on July 1, 2011. The tPA utilization, door-to-needle (DTN) time, imaging-to-needle (ITN) time, and independent ambulation at hospital discharge were compared between the ..
  44. He S, Ding L, Pan Y, Hu H, Ye L, Ren H. Effect of hydraulic retention time on nitrogen removal and functional gene quantity/transcription in biochar packed reactors at 5 °C: A control-strategy study. Bioresour Technol. 2018;264:400-405 pubmed publisher
    ..time (HRT = 8, 12, 16, and 24 h) on effluent dissolved organic nitrogen (DON), dissolved total nitrogen (DTN), and functional gene quantity/transcription in biochar packed reactors over a 125-day operation at 5 °C...
  45. Burnett M, Zimmermann L, Coralic Z, Quon T, Whetstone W, Kim A. Simple text-messaging intervention is associated with improved door-to-needle times for acute ischemic stroke. Stroke. 2014;45:3714-6 pubmed publisher
    ..We developed and evaluated a simple quality improvement intervention designed to improve door-to-needle (DTN) times for resident-led Code Stroke teams at an academic medical center...
  46. Greenberg K, Maxwell C, Moore K, D Ambrosio M, Liebman K, Veznedaroglu E, et al. Improved door-to-needle times and neurologic outcomes when IV tissue plasminogen activator is administered by emergency physicians with advanced neuroscience training. Am J Emerg Med. 2015;33:234-7 pubmed publisher
    ..Door-to-needle (DTN) times, discharge location, and discharge National Institute of Health Stroke Scale (NIHSS) scores were studied ..
  47. Gu R, Xu J. Effects of Cavity on the Performance of Dual Throat Nozzle During the Thrust-Vectoring Starting Transient Process. J Eng Gas Turbine Power. 2014;136:0145021-145026 pubmed
    The dual throat nozzle (DTN) technique is capable to achieve higher thrust-vectoring efficiencies than other fluidic techniques, without compromising thrust efficiency significantly during vectoring operation...
  48. Almeida R, Oliveira R, Luis M, Senna C, Sargento S. A Multi-Technology Communication Platform for Urban Mobile Sensing. Sensors (Basel). 2018;18: pubmed publisher
    ..It also implements mobile Opportunistic VEhicular (mOVE), a delay-tolerant network (DTN)-based architecture to address the mobility dimension...
  49. Prabhakaran S, Khorzad R, Brown A, Nannicelli A, Khare R, Holl J. Academic-Community Hospital Comparison of Vulnerabilities in Door-to-Needle Process for Acute Ischemic Stroke. Circ Cardiovasc Qual Outcomes. 2015;8:S148-54 pubmed publisher
    Although best practices have been developed for achieving door-to-needle (DTN) times ≤60 minutes for stroke thrombolysis, critical DTN process failures persist...
  50. Sanders K, Patel R, Kiely J, Gwynn M, Johnston L. Improving Telestroke Treatment Times in an Expanding Network of Hospitals. J Stroke Cerebrovasc Dis. 2016;25:288-91 pubmed publisher
    ..Primary outcome measures were average door-to-needle (DTN) time for TPA administration and average call-to-needle (CTN) time...
  51. Navalkele D, Cai C, Vahidy F, Rahbar M, Pandurengan R, Wu T, et al. Higher prehospital blood pressure prolongs door to needle thrombolysis times: a target for quality improvement?. Am J Emerg Med. 2016;34:1268-72 pubmed publisher
    ..No studies have focused on prehospital BP and its impact on door to needle (DTN) times. We hypothesized that DTN times would be longer for patients with higher prehospital BP...
  52. Threlkeld Z, Kozak B, McCoy D, Cole S, Martin C, Singh V. Collaborative Interventions Reduce Time-to-Thrombolysis for Acute Ischemic Stroke in a Public Safety Net Hospital. J Stroke Cerebrovasc Dis. 2017;26:1500-1505 pubmed publisher
    ..for AIS at our institution between 2008 and 2015 were included in a retrospective analysis of door-to-needle (DTN) time and associated factors. Between 2011 and 2014, we implemented 11 distinct interventions to reduce DTN time...
  53. Andrew B, Stack C, Yang J, Dodds J. mStroke: "Mobile Stroke"-Improving Acute Stroke Care with Smartphone Technology. J Stroke Cerebrovasc Dis. 2017;26:1449-1456 pubmed publisher
    ..Comparison of metrics (door-to-needle time [DTN] and door-to-CT time [DTC], and rate of DTN???60 minutes [goal DTN]) was performed between subgroups based on ..
  54. Nagaoka N, Yamashita A, Kurisu R, Watari Y, Ishizuna F, Tsutsumi N, et al. DRP3 and ELM1 are required for mitochondrial fission in the liverwort Marchantia polymorpha. Sci Rep. 2017;7:4600 pubmed publisher
    ..Two of them, DRP3 (dynamin-related protein3) and FIS1 (FISSION1), are well conserved in eukaryotes...
  55. Hsieh M, Tang S, Chiang W, Tsai L, Jeng J, Ma M. Effect of prehospital notification on acute stroke care: a multicenter study. Scand J Trauma Resusc Emerg Med. 2016;24:57 pubmed publisher
    ..may shorten the time between hospital arrival and brain computed tomography (door-to-CT) and the door-to-needle (DTN) time...
  56. Urquiza Aguiar L, Tripp Barba C, Aguilar Igartua M. A Geographical Heuristic Routing Protocol for VANETs. Sensors (Basel). 2016;16: pubmed publisher
    ..Recently, Delay-Tolerant Network (DTN) routing protocols have increased their popularity among the research community for being used in non-safety VANET ..
  57. Sauser Zachrison K, Levine D, Fonarow G, Bhatt D, Cox M, Schulte P, et al. Timely Reperfusion in Stroke and Myocardial Infarction Is Not Correlated: An Opportunity for Better Coordination of Acute Care. Circ Cardiovasc Qual Outcomes. 2017;10: pubmed publisher
    ..was a positive correlation between hospital performance on door-to-balloon (D2B) time for STEMI and door-to-needle (DTN) time for AIS, with and without controlling for patient and hospital differences...
  58. Gupta B, Pathak S, Poudel B, Regmi S, Ruttala H, Gautam M, et al. Folate receptor-targeted hybrid lipid-core nanocapsules for sequential delivery of doxorubicin and tanespimycin. Colloids Surf B Biointerfaces. 2017;155:83-92 pubmed publisher
    ..hybrid lipid-core nanocapsules comprising a hybrid lipid core lodging TNP and a polymeric corona lodging DOX (F-DTN)...
  59. Anita K, Premlatha M, Kanagavel M, Akino Mercy C, Raja V, Shanmughapriya S, et al. Evaluation of combined B cell specific N-terminal immunogenic domains of LipL21 for diagnosis of leptospirosis. Int J Biol Macromol. 2016;91:465-70 pubmed publisher
    ..Epitope1 ACS STD TGQ KDA TTV GDG (1.8837), Epitope2 WGG PPE QRN DGK TPR DTN (0.9483), Epitope3 VKG VGV YEC KAT GSG SDP (1.4077) and Epitope4 NEW ECQ CVI YAK FPG GKD (0.4462) were predicted...
  60. Kamal N, Holodinsky J, Stephenson C, Kashayp D, Demchuk A, Hill M, et al. Improving Door-to-Needle Times for Acute Ischemic Stroke: Effect of Rapid Patient Registration, Moving Directly to Computed Tomography, and Giving Alteplase at the Computed Tomography Scanner. Circ Cardiovasc Qual Outcomes. 2017;10: pubmed publisher
    The effectiveness of specific systems changes to reduce DTN (door-to-needle) time has not been fully evaluated. We analyzed the impact of 4 specific DTN time reduction strategies implemented prospectively in a staggered fashion...
  61. Ibrahim F, Akhtar N, Salam A, Kamran S, Deleu D, D Souza A, et al. Stroke Thrombolysis Protocol Shortens "Door-to-Needle Time" and Improves Outcomes-Experience at a Tertiary Care Center in Qatar. J Stroke Cerebrovasc Dis. 2016;25:2043-6 pubmed publisher
    To assess the effect of acute thrombolysis protocol on "door-to-needle time" (DTN) and improvement in outcome following acute stroke (AS)...
  62. Bhatt A, Lesko A, Lucas L, Kansara A, Baraban E. Patients with Low National Institutes of Health Stroke Scale Scores Have Longer Door-to-Needle Times: Analysis of a Telestroke Network. J Stroke Cerebrovasc Dis. 2016;25:2253-8 pubmed publisher
    ..of Health Stroke Scale (NIHSS) scores, indicating a less severe stroke, would have longer door-to-needle (DTN) times compared to patients with higher NIHSS scores...
  63. Hébant B, Triquenot Bagan A, Guegan Massardier E, Ozkul Wermester O, Grangeon L, Maltete D. Impact of an intrahospital mobile thrombolysis team on 3-month clinical outcomes in patients benefiting from intravenous thrombolysis for acute ischemic stroke. Rev Neurol (Paris). 2017;173:152-158 pubmed publisher
    ..MTT allowed significant decreases in the median onset-to-treatment (OTT) time of 26min and median door-to-needle (DTN) time of 27min (P<0.001)...
  64. Advani R, Naess H, Kurz M. The golden hour of acute ischemic stroke. Scand J Trauma Resusc Emerg Med. 2017;25:54 pubmed publisher
    ..onwards, systematic changes were made to the AIS treatment chain leading to a dramatic decrease in Door-to-Needle (DTN) time...
  65. Birnbaum L, Rodriguez J, Topel C, Behrouz R, Misra V, Palacio S, et al. Older Stroke Patients with High Stroke Scores Have Delayed Door-To-Needle Times. J Stroke Cerebrovasc Dis. 2016;25:2668-2672 pubmed publisher
    ..t-PA) to acute ischemic stroke patients from the period of symptom presentation to treatment, door-to-needle (DTN) time, is an important focus for quality improvement and best clinical practice...
  66. Mao R, Zhang X, Li S, Song C. Long-term phosphorus addition enhances the biodegradability of dissolved organic carbon in a nitrogen-limited temperate freshwater wetland. Sci Total Environ. 2017;605-606:332-336 pubmed publisher
    ..Here, we investigated the changes in the ratio of DOC to dissolved total nitrogen (DTN), specific UV absorbance at 254nm (SUVA254), and DOC biodegradation in surface water and soil pore water ..
  67. Moumeni A, Satoh K, Venuprasad R, Serraj R, Kumar A, Leung H, et al. Transcriptional profiling of the leaves of near-isogenic rice lines with contrasting drought tolerance at the reproductive stage in response to water deficit. BMC Genomics. 2015;16:1110 pubmed publisher
    ..Drought tolerance in the highly drought-tolerant NIL (DTN), IR77298-14-1-2-B-10, could be attributed to the up-regulation of genes with calcium ion binding, transferase, ..
  68. Frejo L, Giegling I, Teggi R, Lopez Escamez J, Rujescu D. Genetics of vestibular disorders: pathophysiological insights. J Neurol. 2016;263 Suppl 1:S45-53 pubmed publisher
    ..By using whole exome sequencing and combining bioinformatics tools, novel variants in DTNA and FAM136A genes have been identified in familial Meniere's disease, and this genomic strategy will facilitate the ..
  69. Sablot D, Gaillard N, Colas C, Smadja P, Gely C, Dutray A, et al. Results of a 1-year quality-improvement process to reduce door-to-needle time in acute ischemic stroke with MRI screening. Rev Neurol (Paris). 2017;173:47-54 pubmed publisher
    To determine the effects of a 1-year quality-improvement (QI) process to reduce door-to-needle (DTN) time in a secondary general hospital in which multimodal MRI screening is used before tissue plasminogen activator (tPA) administration ..
  70. Roest S, Visser T, Zeelenberg R. Dutch taboo norms. Behav Res Methods. 2018;50:630-641 pubmed publisher
    ..Finally, words rated high on taboo and insult rated high on arousal. The Dutch Taboo Norms (DTN) database is a useful tool for researchers interested in the effects of taboo words on cognitive processing...
  71. Tokunaga A, Ono K, Kondo S, Tanaka H, Kurose K, Nagai H. Retinal projections in the house musk shrew, Suncus murinus, as determined by anterograde transport of WGA-HRP. Brain Behav Evol. 1992;40:321-9 pubmed
    ..IGL), the pretectum, the superficial layers of the superior colliculus (CS), and the dorsal terminal nucleus (DTN) of the accessory optic system (AOS)...
  72. Cherif H, Argaw A, Cécyre B, Bouchard A, Gagnon J, Javadi P, et al. Role of GPR55 during Axon Growth and Target Innervation. Eneuro. 2015;2: pubmed publisher
    ..to their wild-type (WT) littermates, gpr55(-/-) mice revealed a decreased branching in the dorsal terminal nucleus (DTN) and a lower level of eye-specific segregation of retinal projections in the superior colliculus (SC) and in the ..
  73. Nardetto L, Dario C, Tonello S, Brunelli M, Lisiero M, Carraro M, et al. A one-to-one telestroke network: the first Italian study of a web-based telemedicine system for thrombolysis delivery and patient monitoring. Neurol Sci. 2016;37:725-30 pubmed publisher
    ..test yielded no statistically significant differences between the two populations in door-to-scan, door-to-needle (DTN), and onset-to-treatment times (OTT)...
  74. Compton A, Cooper S, Hill P, Yang N, Froehner S, North K. The syntrophin-dystrobrevin subcomplex in human neuromuscular disorders. J Neuropathol Exp Neurol. 2005;64:350-61 pubmed
  75. Khurana T, Engle E, Bennett R, Silverman G, Selig S, Bruns G, et al. (CA) repeat polymorphism in the chromosome 18 encoded dystrophin-like protein. Hum Mol Genet. 1994;3:841 pubmed
  76. Ueda H, Baba T, Kashiwagi K, Iijima H, Ohno S. Dystrobrevin localization in photoreceptor axon terminals and at blood-ocular barrier sites. Invest Ophthalmol Vis Sci. 2000;41:3908-14 pubmed
    ..In addition, dystrobrevin is localized at the blood-ocular barrier sites in extraocular tissue. These data suggest that dystrobrevin plays an important role in visual function. ..
  77. Blake D. Dystrobrevin dynamics in muscle-cell signalling: a possible target for therapeutic intervention in Duchenne muscular dystrophy?. Neuromuscul Disord. 2002;12 Suppl 1:S110-7 pubmed
    ..This article discusses the function of dystrobrevin in muscle and reviews its suitability as a therapeutic target for treating patients with Duchenne and Becker muscular dystrophies. ..
  78. Requena T, Cabrera S, Martín Sierra C, Price S, Lysakowski A, Lopez Escamez J. Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease. Hum Mol Genet. 2015;24:1119-26 pubmed publisher
    ..By whole-exome sequencing, we have identified two novel heterozygous single-nucleotide variants in FAM136A and DTNA genes, both in a Spanish family with three affected cases in consecutive generations, highly suggestive of ..
  79. Sadoulet Puccio H, Feener C, Schaid D, Thibodeau S, Michels V, Kunkel L. The genomic organization of human dystrobrevin. Neurogenetics. 1997;1:37-42 pubmed
    ..Based on intronic sequence, a primer set was designed to specifically amplify each exon of dystrobrevin to screen for mutations by SSCP in patients with neuromuscular diseases for which dystrobrevin could be a candidate. ..
  80. Hoshino S, Ohkoshi N, Ishii A, Shoji S. The expression of alpha-dystrobrevin and dystrophin during skeletal muscle regeneration. J Muscle Res Cell Motil. 2002;23:131-8 pubmed
    ..6 and 5.3 days, respectively. These data provide evidence that alpha-dystrobrevin regenerates more slowly than dystrophin in skeletal muscle. ..
  81. Lanciotti A, Brignone M, Camerini S, Serafini B, Macchia G, Raggi C, et al. MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation. Neurobiol Dis. 2010;37:581-95 pubmed publisher
    ..Because pathological mutations prevent MLC1 membrane expression, the identification of substances regulating MLC1 intracellular trafficking is potentially relevant for the therapy of MLC. ..
  82. Rostanski S, Shahn Z, Elkind M, Liberman A, Marshall R, Stillman J, et al. Door-to-Needle Delays in Minor Stroke: A Causal Inference Approach. Stroke. 2017;48:1980-1982 pubmed publisher
    ..We examined the association of delays in door-to-needle (DTN) time with stroke severity...
  83. Huang Y, Li P, Chen G, Peng L, Chen X. The production of cyanobacterial carbon under nitrogen-limited cultivation and its potential for nitrate removal. Chemosphere. 2018;190:1-8 pubmed publisher
    ..amount of dissolved organic carbon (DOC) and carbohydrates, but a smaller amount of dissolved total nitrogen (DTN) and proteins...
  84. Rostanski S, Stillman J, Schaff L, Perdomo C, Liberman A, Miller E, et al. E-Mail Is an Effective Tool for Rapid Feedback in Acute Stroke. Neurohospitalist. 2017;7:159-163 pubmed publisher
    ..whether e-mail is a useful mechanism to provide prompt, case-specific data feedback and improve door-to-needle (DTN) time for acute ischemic stroke treated with intravenous tissue plasminogen activator (IV-tPA) in the emergency ..
  85. Cao Q, Shen Y, Liu X, Yu X, Yuan P, Wan R, et al. Phenotype and Functional Analyses in a Transgenic Mouse Model of Left Ventricular Noncompaction Caused by a DTNA Mutation. Int Heart J. 2017;: pubmed publisher
    b>DTNA encoding dystrobrevin-? (?-DB) is a putative causal gene associated with left ventricular noncompaction cardiomyopathy (LVNC). The aim of the study was to investigate the causal role of DTNA in LVNC using a transgenic mouse model...
  86. Metzinger L, Blake D, Squier M, Anderson L, Deconinck A, Nawrotzki R, et al. Dystrobrevin deficiency at the sarcolemma of patients with muscular dystrophy. Hum Mol Genet. 1997;6:1185-91 pubmed
    ..This is the first indication that a cytoplasmic component of the dystrophin-associated protein complex may be involved in the pathogenesis of limb-girdle muscular dystrophy. ..
  87. Kulyté A, Navakauskiene R, Treigyte G, Gineitis A, Bergman T, Magnusson K. Characterization of human alpha-dystrobrevin isoforms in HL-60 human promyelocytic leukemia cells undergoing granulocytic differentiation. Mol Biol Cell. 2002;13:4195-205 pubmed
  88. Borutinskaite V, Magnusson K, Navakauskiene R. ?-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation. Mol Biol Rep. 2011;38:3001-11 pubmed publisher
  89. Straub V, Campbell K. Muscular dystrophies and the dystrophin-glycoprotein complex. Curr Opin Neurol. 1997;10:168-75 pubmed
  90. Ozawa E, Noguchi S, Mizuno Y, Hagiwara Y, Yoshida M. From dystrophinopathy to sarcoglycanopathy: evolution of a concept of muscular dystrophy. Muscle Nerve. 1998;21:421-38 pubmed
    ..In this review, the evolution of the concept of sarcoglycanopathy separate from that of dystrophinopathy is explained by comparing studies on these diseases. ..
  91. Grady R, Akaaboune M, Cohen A, Maimone M, Lichtman J, Sanes J. Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions. J Cell Biol. 2003;160:741-52 pubmed
    ..More generally, alphaDB may play multiple roles in muscle by means of differential distribution of isoforms with distinct signaling or structural properties...
  92. Nguyen Huynh M, Klingman J, Avins A, Rao V, Eaton A, Bhopale S, et al. Novel Telestroke Program Improves Thrombolysis for Acute Stroke Across 21 Hospitals of an Integrated Healthcare System. Stroke. 2018;49:133-139 pubmed publisher
    ..Northern California's Stroke EXpediting the PRrocess of Evaluating and Stopping Stroke program on door-to-needle (DTN) time, alteplase use, and symptomatic intracranial hemorrhage rates...