DSPP

Summary

Gene Symbol: DSPP
Description: dentin sialophosphoprotein
Alias: DFNA39, DGI1, DMP3, DPP, DSP, dentin sialophosphoprotein, dentin phosphophoryn, dentin phosphoprotein, dentin phosphoryn, dentin sialoprotein
Species: human
Products:     DSPP

Top Publications

  1. Song Y, Wang C, Fan M, Su B, Bian Z. Dentin phosphoprotein frameshift mutations in hereditary dentin disorders and their variation patterns in normal human population. J Med Genet. 2008;45:457-64 pubmed publisher
    b>Dentin phosphoprotein (DPP) is the most abundant non-collagenous protein in dentin, which is highly phosphorylated and plays key roles in dentin biomineralization...
  2. McKnight D, Suzanne Hart P, Hart T, Hartsfield J, Wilson A, Wright J, et al. A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene. Hum Mutat. 2008;29:1392-404 pubmed publisher
    ..III) patient/families, seven have 1 of 4 net -1 deletions within the approximately 2-kb coding repeat domain of the DSPP gene while the remaining two patients have splice-site mutations...
  3. McKnight D, Simmer J, Hart P, Hart T, Fisher L. Overlapping DSPP mutations cause dentin dysplasia and dentinogenesis imperfecta. J Dent Res. 2008;87:1108-11 pubmed
    Dentinogenesis imperfecta (DGI) and dentin dysplasia (DD) are allelic disorders due to mutations in DSPP. Typically, the phenotype breeds true within a family...
  4. Zhang X, Zhao J, Li C, Gao S, Qiu C, Liu P, et al. DSPP mutation in dentinogenesis imperfecta Shields type II. Nat Genet. 2001;27:151-2 pubmed
    We identified a nonsense mutation (Gln45stop) in exon 3 of the dentin sialophosphoprotein (DSPP) gene in a Chinese family with dentinogenesis imperfecta Shields type II (DGI-II), in which the affected members showed discoloration and ..
  5. Paine M, Luo W, Wang H, Bringas P, Ngan A, Miklus V, et al. Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis. J Biol Chem. 2005;280:31991-8 pubmed
    The gene for dentin sialophosphoprotein produces a single protein that is post-translationally modified to generate two distinct extracellular proteins: dentin sialoprotein and dentin phosphoprotein...
  6. Kida M, Tsutsumi T, Shindoh M, Ikeda H, Ariga T. De novo mutation in the DSPP gene associated with dentinogenesis imperfecta type II in a Japanese family. Eur J Oral Sci. 2009;117:691-4 pubmed publisher
    ..53T>A, p.V18D, g.1192T>A) involving the second nucleotide of the first codon within exon 3 of the dentin sialophosphoprotein (DSPP) gene. This mutation has previously been reported in a Korean family...
  7. MacDougall M, Simmons D, Luan X, Nydegger J, Feng J, Gu T. Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determination. J Biol Chem. 1997;272:835-42 pubmed
    ..Therefore, we propose that the gene be named dentin sialophosphoprotein. The location of the human dentin sialophosphoprotein gene on chromosome 4 suggests that this gene may ..
  8. Acevedo A, Santos L, Paula L, Dong J, MacDougall M. Phenotype characterization and DSPP mutational analysis of three Brazilian dentinogenesis imperfecta type II families. Cells Tissues Organs. 2009;189:230-6 pubmed publisher
    The aim of this study was to perform phenotype analysis and dentin sialophosphoprotein (DSPP) mutational analysis on 3 Brazilian families diagnosed with dentinogenesis imperfecta type II (DGI-II) attending the Dental Anomalies Clinic in ..
  9. Ogbureke K, Fisher L. Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs). Kidney Int. 2005;68:155-66 pubmed
    ..b>Dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE) were expressed in the proximal tubule and ..

More Information

Publications104 found, 100 shown here

  1. Lee S, Hu J, Lee K, Simmer J, Kim J. A dentin sialophosphoprotein mutation that partially disrupts a splice acceptor site causes type II dentin dysplasia. J Endod. 2008;34:1470-3 pubmed publisher
    The dentin sialophosphoprotein (DSPP) gene on chromosome 4q21.3 encodes the major noncollagenous protein in tooth dentin...
  2. Wang H, Hou Y, Cui Y, Huang Y, Shi Y, Xia X, et al. A novel splice site mutation in the dentin sialophosphoprotein gene in a Chinese family with dentinogenesis imperfecta type II. Mutat Res. 2009;662:22-7 pubmed publisher
    ..In the critical region between D4S1534 and DMP1, the dentin sialophosphoprotein (DSPP) gene (OMIM *125485) was considered as the strongest candidate gene...
  3. Lee S, Lee K, Jeon D, Lee G, Lee H, Shin C, et al. A novel mutation in the DSPP gene associated with dentinogenesis imperfecta type II. J Dent Res. 2009;88:51-5 pubmed publisher
    ..We hypothesized that a mutation in the DSPP gene is responsible for this severe phenotype. Mutational analyses revealed a novel mutation (c.53T>A, p...
  4. Yang R, Lim G, Dong Z, Lee A, Yee C, Fuller R, et al. The efficiency of dentin sialoprotein-phosphophoryn processing is affected by mutations both flanking and distant from the cleavage site. J Biol Chem. 2013;288:6024-33 pubmed publisher
    Normal dentin mineralization requires two highly acidic proteins, dentin sialoprotein (DSP) and phosphophoryn (PP)...
  5. MacDougall M. Refined mapping of the human dentin sialophosphoprotein (DSPP) gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci. Eur J Oral Sci. 1998;106 Suppl 1:227-33 pubmed
    ..and dentin phosphoprotein (DPP, phosphophoryn) have been shown to be encoded by a single gene, termed dentin sialophosphoprotein (DSPP), which has been mapped to human chromosome 4...
  6. Qin C, Brunn J, Cadena E, Ridall A, Tsujigiwa H, Nagatsuka H, et al. The expression of dentin sialophosphoprotein gene in bone. J Dent Res. 2002;81:392-4 pubmed
    ..DPP) are expressed as a single mRNA transcript coding for a large precursor protein termed dentin sialophosphoprotein (DSPP). DSP, DPP, and DSPP have been considered to be tooth-specific...
  7. Von Marschall Z, Fisher L. Dentin sialophosphoprotein (DSPP) is cleaved into its two natural dentin matrix products by three isoforms of bone morphogenetic protein-1 (BMP1). Matrix Biol. 2010;29:295-303 pubmed publisher
    The protease that cleaves the most abundant non-collagenous protein of dentin matrix, dentin sialophosphoprotein (DSPP), into its two final dentin matrix products, dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), has not been ..
  8. Von Marschall Z, Mok S, Phillips M, McKnight D, Fisher L. Rough endoplasmic reticulum trafficking errors by different classes of mutant dentin sialophosphoprotein (DSPP) cause dominant negative effects in both dentinogenesis imperfecta and dentin dysplasia by entrapping normal DSPP. J Bone Miner Res. 2012;27:1309-21 pubmed publisher
    ..imperfecta (DGI) and the milder, dentin dysplasia (DD), have mutations in one allele of the dentin sialophosphoprotein (DSPP) gene...
  9. Xiao S, Yu C, Chou X, Yuan W, Wang Y, Bu L, et al. Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet. 2001;27:201-4 pubmed
    ..We identified three disease-specific mutations within the dentin sialophosphoprotein gene (DSPP) in these three families...
  10. Joshi R, Tawfik A, Edeh N, McCloud V, Looney S, Lewis J, et al. Dentin sialophosphoprotein (DSPP) gene-silencing inhibits key tumorigenic activities in human oral cancer cell line, OSC2. PLoS ONE. 2010;5:e13974 pubmed publisher
    We determined recently that dentin sialophosphoprotein (DSPP), a member of the SIBLING (Small integrin-binding ligand N-linked glycoproteins) family of phosphoglycoproteins, is highly upregulated in human oral squamous cell carcinomas (..
  11. Suzuki S, Haruyama N, Nishimura F, Kulkarni A. Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues. Arch Oral Biol. 2012;57:1165-75 pubmed publisher
    b>Dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1) are highly phosphorylated proteins that belong to the family of small integrin-binding ligand N-linked glycoproteins (SIBLINGs), and are essential for proper ..
  12. Song Y, Wang C, Peng B, Ye X, Zhao G, Fan M, et al. Phenotypes and genotypes in 2 DGI families with different DSPP mutations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:360-74 pubmed
    ..The objective of this study was to characterize dentin ultrastructural features resulting from a nonsense mutation in DSPP gene and to define various phenotypes associated with specific DSPP mutations in families with Dentinogenesis ..
  13. Prasad M, Butler W, Qin C. Dentin sialophosphoprotein in biomineralization. Connect Tissue Res. 2010;51:404-17 pubmed publisher
    ..DPP and DSP are the cleavage products of dentin sialophosphoprotein (DSPP)...
  14. Nieminen P, Papagiannoulis Lascarides L, Waltimo Siren J, Ollila P, Karjalainen S, Arte S, et al. Frameshift mutations in dentin phosphoprotein and dependence of dentin disease phenotype on mutation location. J Bone Miner Res. 2011;26:873-80 pubmed publisher
    We describe results from a mutational analysis of the region of the dentin sialophosphoprotein (DSPP) gene encoding dentin phosphoprotein (DPP) in 12 families with dominantly inherited dentin diseases...
  15. Li D, Du X, Zhang R, Shen B, Huang Y, Valenzuela R, et al. Mutation identification of the DSPP in a Chinese family with DGI-II and an up-to-date bioinformatic analysis. Genomics. 2012;99:220-6 pubmed publisher
    ..Chinese family with multiple members afflicted with DGI (type II), we identified a novel missense mutation in DSPP. The mutation was located in exon 2 at the second nucleotide position of the last codon and resulted in a ..
  16. Ogbureke K, Fisher L. Expression of SIBLINGs and their partner MMPs in salivary glands. J Dent Res. 2004;83:664-70 pubmed
    ..The 2 SIBLING proteins without known MMP partners, dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE), were also expressed in salivary glands...
  17. Zhang X, Chen L, Liu J, Zhao Z, Qu E, Wang X, et al. A novel DSPP mutation is associated with type II dentinogenesis imperfecta in a Chinese family. BMC Med Genet. 2007;8:52 pubmed
    ..One disease-causing gene, the dentin sialophosphoprotein (DSPP) gene, has been reported for type II DGI...
  18. Ravindran S, Snee P, Ramachandran A, George A. Acidic domain in dentin phosphophoryn facilitates cellular uptake: implications in targeted protein delivery. J Biol Chem. 2013;288:16098-109 pubmed publisher
    b>Dentin phosphophoryn is nature's most acidic protein found predominantly in the dentin extracellular matrix. Its unique amino acid composition containing Asp-Ser (DS)-rich repeats makes it highly anionic...
  19. Ahn Y, Kim T, Choi H, Bae C, Yang Y, Baek J, et al. Disruption of Tgfbr2 in odontoblasts leads to aberrant pulp calcification. J Dent Res. 2015;94:828-35 pubmed publisher
    ..In mutant dentin, Dsp expression was reduced, but Dmp1 expression increased significantly...
  20. Verdelis K, Szabo Rogers H, Xu Y, Chong R, Kang R, Cusack B, et al. Accelerated enamel mineralization in Dspp mutant mice. Matrix Biol. 2016;52-54:246-259 pubmed publisher
    b>Dentin sialophosphoprotein (DSPP) is one of the major non-collagenous proteins present in dentin, cementum and alveolar bone; it is also transiently expressed by ameloblasts...
  21. Huang X, Wang F, Zhao C, Yang S, Cheng Q, Tang Y, et al. Dentinogenesis and tooth-alveolar bone complex defects in <i>BMP9/GDF2</i> knockout mice. Stem Cells Dev. 2019;: pubmed publisher
    ..Mechanistically, we demonstrated that both Dspp and Dmp1 were induced in dental stem cells by BMP9, while their expression was reduced when BMP9 was silenced...
  22. Hu A, Li X, Chen D, Lu T, Huang J, Xu X, et al. [Analysis of DSPP gene mutation in a Chinese pedigree affected with hereditary dentinogenesis imperfecta]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018;35:511-514 pubmed publisher
    ..phenotype of a Chinese pedigree affected with hereditary dentinogenesis imperfecta and mutation of dentin sialophosphoprotein (DSPP) gene. Affected members underwent intraoral photography, dental film and panoramic radiography...
  23. Yuan G, Chen L, Feng J, Yang G, Ni Q, Xu X, et al. Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo. Sci Rep. 2017;7:42449 pubmed publisher
    b>Dentin sialoprotein (DSP) is essential for dentinogenesis and processed into fragments in the odontoblast-like cells and the tooth compartments. Matrix metalloproteinase 9 (MMP9) is expressed in teeth from early embryonic to adult stage...
  24. Porntaveetus T, Osathanon T, Nowwarote N, Pavasant P, Srichomthong C, Suphapeetiporn K, et al. Dental properties, ultrastructure, and pulp cells associated with a novel DSPP mutation. Oral Dis. 2018;24:619-627 pubmed publisher
    ..of dental pulp cells of teeth isolated from a dentinogenesis imperfecta (DGI) patient with a novel dentin sialophosphoprotein (DSPP) mutation. Whole exome and Sanger sequencing were employed to identify mutations...
  25. Adeghate E, Kalasz H, Veress G, Teke K. Medicinal chemistry of drugs used in diabetic cardiomyopathy. Curr Med Chem. 2010;17:517-51 pubmed
    ..glucosidase inhibitors, sulfonylureas, biguanides, meglitinides, thiazolidinediones and dipeptidyl peptidase 4 (DPP-4) inhibitors); hormones (IGF-1); ACE inhibitors (captopril, enalapril); angiotensin II receptor antagonists (..
  26. Yisireyili M, Takeshita K, Hayashi M, Wu H, Uchida Y, Yamamoto K, et al. Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model. Psychoneuroendocrinology. 2016;73:186-195 pubmed publisher
    ..Glucose metabolism was assessed by glucose and insulin tolerance tests, plasma levels of DPP-4 activity, glucagon-like peptide-1, expression of DPP-4, insulin receptor substrate-1 and glucose transporter 4 in ..
  27. Fanjiang Y, Lu S. Dynamic Synchronous Capture Algorithm for an Electromagnetic Flowmeter. Sensors (Basel). 2017;17: pubmed publisher
    ..The DSC algorithm can be applied to the current general MCU firmware platform without using DSP (Digital Signal Processing) or a high-speed and high-end MCU platform, and signal amplification by hardware reduces ..
  28. Alzahrani S, Nelson J, Moss S, Paulus J, Knowler W, Pittas A. H. pylori seroprevalence and risk of diabetes: An ancillary case-control study nested in the diabetes prevention program. J Diabetes Complications. 2017;31:1515-1520 pubmed publisher
    ..risk of incident diabetes in adults at high risk for diabetes who participated in the Diabetes Prevention Program (DPP) study...
  29. Matthews D, Diskin M, Kenny D, Creevey C, Keogh K, Waters S. Effect of short term diet restriction on gene expression in the bovine hypothalamus using next generation RNA sequencing technology. BMC Genomics. 2017;18:857 pubmed publisher
    ..Q1KLR3, IFIH1, IL1 and IL8; RA v C and RA v RO); energy homeostasis (AgRP and NPY; RA v RO); cell motility (CADH1, DSP and TSP4; RO v C) and prevention of GnRH release (NTSR1 IL1?, IL1?, NPY and PACA; RA v RO)...
  30. Yin X, Zeng Z, Xing J, Zhang A, Jiang W, Wang W, et al. Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast?lineage cells. Int J Mol Med. 2018;41:331-339 pubmed publisher
    ..Furthermore, stable Hey1?overexpressing cells expressed higher levels of dentin sialophosphoprotein (DSPP) and exhibited higher mineralization capabilities following stimulation by differentiation medium...
  31. Wang Y, Hu Y, Zhang F. Effects of GPNMB on proliferation and odontoblastic differentiation of human dental pulp cells. Int J Clin Exp Pathol. 2015;8:6498-504 pubmed
    ..ALP) activity assay, qRT-PCR and Western blot were used to determine the expression levels of dentin sialophosphoprotein (DSPP) and dentin matrix protein-1 (DMP-1)...
  32. Newton F, Harris R, Sutcliffe C, Ashe H. Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development. Development. 2015;142:3362-73 pubmed publisher
    ..tumour (Brat) and Pumilio (Pum)-mediated post-transcriptional repression of mRNAs, including that encoding the Dpp transducer, Mad...
  33. Marques C, Cancela M, Laizé V. Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors. Gene. 2016;576:229-36 pubmed publisher
    ..As in other vertebrates, seabream BMP2 gene has a 5′ non-coding exon, a feature already present in DPP gene, the fruit fly ortholog of vertebrate BMP2 gene, and maintained throughout evolution...
  34. Namepetra A, Kitching E, Eftaiha A, Hill I, Welch G. Understanding the morphology of solution processed fullerene-free small molecule bulk heterojunction blends. Phys Chem Chem Phys. 2016;18:12476-85 pubmed publisher
    Bulk-heterojunction (BHJ) molecular blends prepared from small molecules based on diketopyrrolopyrrole (DPP) and perylene-diimide (PDI) chromophores have been studied using optical absorption, cyclic voltammetry, photoluminescence ..
  35. Busek P, Vanickova Z, Hrabal P, Brabec M, Fric P, Zavoral M, et al. Increased tissue and circulating levels of dipeptidyl peptidase-IV enzymatic activity in patients with pancreatic ductal adenocarcinoma. Pancreatology. 2016;16:829-38 pubmed publisher
    ..Dipeptidyl peptidase-IV (DPP-IV) and fibroblast activation protein alpha (FAP) are aminopeptidases that regulate several bioactive peptides ..
  36. Guo L, Jin L, Du J, Zhang C, Fan Z, Wang S. Depletion of SHANK2 inhibited the osteo/dentinogenic differentiation potentials of stem cells from apical papilla. Histol Histopathol. 2017;32:471-479 pubmed publisher
    ..using ALP staining, ALP activity, alizarin red staining, quantitative calcium, the expression levels of DSPP, DMP1, RUNX2 and OSX...
  37. Kodera R, Shikata K, Nakamura A, Okazaki S, Nagase R, Nakatou T, et al. The Glucose-lowering Efficacy of Sitagliptin in Obese Japanese Patients with Type 2 Diabetes. Intern Med. 2017;56:605-613 pubmed publisher
    Objective Dipeptidyl peptidase-4 (DPP-4) inhibitors are the most frequently prescribed oral hypoglycemic agents in Japan...
  38. Kim Y, Song C, Suranagi S, Lee J, Park C. Markedly different molecular formation in DPP-based small-molecule solar cells probed by grazing-incidence wide-angle X-ray scattering. Acta Crystallogr B Struct Sci Cryst Eng Mater. 2017;73:916-922 pubmed publisher
    This study comprehensively explores the nanostructural properties of two diketopyrrolo[3,4-c]pyrrole-1,4-dione (DPP)-based small molecules with different alkyl side groups and their blends with the fullerene derivative PC71BM, ..
  39. Wellard S, Hopkins J, Jordan P. A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model. J Vis Exp. 2018;: pubmed publisher
    ..The first wave of mouse spermatocytes undergoing meiotic initiation appear at day 10 post-partum (10 dpp) and are released into the lumen of seminiferous tubules as mature sperm at 35 dpp...
  40. Yu L, Lin X, Liu H, Shi J, Nong Q, Tang H, et al. Sex and Age Differences in Mortality in Southern China, 2004-2010. Int J Environ Res Public Health. 2015;12:7886-98 pubmed publisher
    ..mortality and population data from January 2004 to December 2010 were obtained from 12 Disease Surveillance Point (DSP) sites in four provinces of China...
  41. Steinan M, Morken G, Lagerberg T, Melle I, Andreassen O, Vaaler A, et al. Delayed sleep phase: An important circadian subtype of sleep disturbance in bipolar disorders. J Affect Disord. 2016;191:156-63 pubmed publisher
    ..studies of sleep in BD have reported on the most prevalent circadian sleep abnormality, namely Delayed Sleep Phase (DSP)...
  42. Rajput M, Sarkar P, Nirmal N. Inhibition of DPP-4 Activity and Neuronal Atrophy with Genistein Attenuates Neurological Deficits Induced by Transient Global Cerebral Ischemia and Reperfusion in Streptozotocin-Induced Diabetic Mice. Inflammation. 2017;40:623-635 pubmed publisher
    ..This study suggests that genistein has potent neuroprotective activity against global cerebral ischemia-reperfusion-induced neuronal injury and consequent neurological deficits in streptozotocin-induced diabetic mice. ..
  43. Patil Y, Misra R, Singh M, Sharma G. Ferrocene-diketopyrrolopyrrole based small molecule donors for bulk heterojunction solar cells. Phys Chem Chem Phys. 2017;19:7262-7269 pubmed publisher
    A symmetrical D-?-A-?-D type small molecule consisting of thiophene flanked diketopyrrolopyrrole (DPP) as a core and an end capping ferrocene donor linked by an ethynyl bridge, denoted as Fc-DPP-Fc, was synthesized and its optical, ..
  44. Nongonierma A, Lalmahomed M, Paolella S, FitzGerald R. Milk protein isolate (MPI) as a source of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides. Food Chem. 2017;231:202-211 pubmed publisher
    ..0, 1.5 and 2.0%)] design of experiments (DOE) was used to optimise the release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides during hydrolysis of bovine milk protein isolate (MPI) with Neutrase 0...
  45. Wink K, Roelofs E, Simone C, Dechambre D, Santiago A, van der Stoep J, et al. Photons, protons or carbon ions for stage I non-small cell lung cancer - Results of the multicentric ROCOCO in silico study. Radiother Oncol. 2018;128:139-146 pubmed publisher
    ..radiotherapy (IMRT), volumetric modulated arc therapy (VMAT) and CyberKnife], a double scattered proton (DSP) and an intensity-modulated carbon-ion (IMIT) therapy plan were created...
  46. Lee S, Lee K, Song S, Hyun H, Lee S, Kim J. A DSPP mutation causing dentinogenesis imperfecta and characterization of the mutational effect. Biomed Res Int. 2013;2013:948181 pubmed publisher
    Mutations in the DSPP gene have been identified in nonsyndromic hereditary dentin defects, but the genotype-phenotype correlations are not fully understood...
  47. Smits M, Tonneijck L, Muskiet M, Hoekstra T, Kramer M, Pieters I, et al. Cardiovascular, renal and gastrointestinal effects of incretin-based therapies: an acute and 12-week randomised, double-blind, placebo-controlled, mechanistic intervention trial in type 2 diabetes. BMJ Open. 2015;5:e009579 pubmed publisher
    Incretin-based therapies, that is, glucagon-like peptide (GLP)-1 receptor agonists and dipeptidyl peptidase (DPP)-4 inhibitors, are relatively novel antihyperglycaemic drugs that are frequently used in type 2 diabetes management...
  48. Shrestha S, Torneck C, Kishen A. Dentin Conditioning with Bioactive Molecule Releasing Nanoparticle System Enhances Adherence, Viability, and Differentiation of Stem Cells from Apical Papilla. J Endod. 2016;42:717-23 pubmed publisher
    ..05). SCAP cultured in Dex-CSnpII group expressed higher levels for DSPP and DMP-1 than in CSnp or Dex-CSnpI groups...
  49. Mannucci E, Monami M. Cardiovascular Safety of Incretin-Based Therapies in Type 2 Diabetes: Systematic Review of Integrated Analyses and Randomized Controlled Trials. Adv Ther. 2017;34:1-40 pubmed publisher
    ..that new drugs for treatment of patients with type 2 diabetes mellitus (T2DM), such as dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, are evaluated to show that they do not ..
  50. Bertone V, Tarantola E, Freitas I. Enzyme-Histochemistry Technique for Visualizing the Dipeptidyl-Peptidase IV (DPP-IV) Activity in the Liver Biliary Tree. Methods Mol Biol. 2017;1560:45-53 pubmed publisher
    ..Here we describe a histochemical method to demonstrate with accuracy and precision its in situ activity on cryostatic section of Wistar rat liver by means of a simultaneous azo-coupling method. ..
  51. Garnock Jones K. Saxagliptin/Dapagliflozin: A Review in Type 2 Diabetes Mellitus. Drugs. 2017;77:319-330 pubmed publisher
    ..As the first dipeptidyl peptidase-4 (DPP-4) inhibitor/sodium-glucose co-transporter (SGLT2) inhibitor fixed-dose combination available in the EU for ..
  52. Caron J, Cudennec B, Domenger D, Belguesmia Y, Flahaut C, Kouach M, et al. Simulated GI digestion of dietary protein: Release of new bioactive peptides involved in gut hormone secretion. Food Res Int. 2016;89:382-390 pubmed publisher
    ..Targeted gut hormones were Cholecystokinin (CCK) and Glucagon-Like Peptide 1 (GLP-1). The activity of DPP-IV was also considered as it strongly modulates GLP-1 action...
  53. Shen F, Yan R. Design and Implementation of a Hypothermic Machine Perfusion Device for Clinical Preservation of Isolated Organs. Sensors (Basel). 2017;17: pubmed publisher
    ..Also, a fuzzy-PID controller contributes to improve the accuracy and reduces the computational load using the DSP. Our experiments indicate that the reliability of the instrument meets the design requirements, thus being ..
  54. Xu J, Wang J, Cheng Y, Li X, He M, Zhu J, et al. Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats. Biomed Res Int. 2018;2018:1864107 pubmed publisher
    ..Sitagliptin (40?mg/kg/d), a classical dipeptidyl peptidase-4 (DPP-4) inhibitor, attenuated the renal microcirculation lesions by inhibiting glomerular tuft hypertrophy, glomerular ..
  55. Nagel A, Ahmed Sarwar N, Werner P, Cipriano G, van Manen R, Brown J. Dipeptidyl Peptidase-4 Inhibitor-Associated Pancreatic Carcinoma: A Review of the FAERS Database. Ann Pharmacother. 2016;50:27-31 pubmed publisher
    To date, there is limited literature regarding the association between dipeptidyl peptidase-4 (DPP-4) inhibitors and pancreatic carcinoma...
  56. Dey N, Ramesh P, Chugh M, Mandal S, Mandal L. Dpp dependent Hematopoietic stem cells give rise to Hh dependent blood progenitors in larval lymph gland of Drosophila. elife. 2016;5: pubmed publisher
    ..These HSCs require Decapentapelagic (Dpp) signal from the hematopoietic niche for their maintenance in an identical manner to vertebrate aorta-gonadal-..
  57. Kitzman H, Dodgen L, Mamun A, Slater J, King G, Slater D, et al. Community-based participatory research to design a faith-enhanced diabetes prevention program: The Better Me Within randomized trial. Contemp Clin Trials. 2017;62:77-90 pubmed publisher
    ..and cardiovascular risk; however, evidence-based lifestyle programs, such as the diabetes prevention program (DPP), show reduced effectiveness in African American (AA) women...
  58. McCurley J, Fortmann A, Gutierrez A, Gonzalez P, Euyoque J, Clark T, et al. Pilot Test of a Culturally Appropriate Diabetes Prevention Intervention for At-Risk Latina Women. Diabetes Educ. 2017;43:631-640 pubmed publisher
    ..effectiveness, feasibility, and acceptability of a peer-led, culturally appropriate, Diabetes Prevention Program (DPP)-based lifestyle intervention for Latina women at high-risk for type 2 diabetes (T2DM)...
  59. Leonardo S, Toldrà A, Rambla Alegre M, Fernández Tejedor M, Andree K, Ferreres L, et al. Self-assembled monolayer-based immunoassays for okadaic acid detection in seawater as monitoring tools. Mar Environ Res. 2018;133:6-14 pubmed publisher
    Rapid and cost-effective methods to monitor the presence of diarrhetic shellfish poisoning (DSP) toxins in seawater samples in an easy and reliable manner are required to protect human health and avoid economic losses to shellfish ..
  60. Zhang N, Lu X, Wu S, Li X, Duan J, Chen C, et al. Intrastriatal transplantation of stem cells from human exfoliated deciduous teeth reduces motor defects in Parkinsonian rats. Cytotherapy. 2018;20:670-686 pubmed publisher
    ..dental pulp and were induced to differentiate to neurons and dopamine neurons by inhibiting similar mothers against dpp (SMAD) signaling with Noggin and increase conversion of dopamine neurons from SHED with CHIR99021, Sonic Hedgehog (..
  61. Luo L, Siah C, Cai Y. Engrailed acts with Nejire to control decapentaplegic expression in the Drosophila ovarian stem cell niche. Development. 2017;144:3224-3231 pubmed publisher
    ..In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC self-renewal...
  62. Zhen E, Jin Z, Ackermann B, Thomas M, Gutierrez J. Circulating FGF21 proteolytic processing mediated by fibroblast activation protein. Biochem J. 2016;473:605-14 pubmed publisher
    ..Dipeptidyl peptidase IV (DPP-IV) was found to be the primary protease responsible for N-terminal cleavages after residues Pro-2 and Pro-4...
  63. Xu F, Wang K, Wang N, Li G, Liu D. Modified human glucagon-like peptide-1 (GLP-1) produced in E. coli has a long-acting therapeutic effect in type 2 diabetic mice. PLoS ONE. 2017;12:e0181939 pubmed publisher
    ..The half-life of GLP-1, however, is very short due to its rapid cleavage by dipeptidyl peptidase IV (DPP-IV). This presents a great challenge if it is to be used as a therapeutic drug...
  64. Men P, He N, Song C, Zhai S. Dipeptidyl peptidase-4 inhibitors and risk of arthralgia: A systematic review and meta-analysis. Diabetes Metab. 2017;43:493-500 pubmed publisher
    The US Food and Drug Administration has warned that treatment with dipeptidyl peptidase (DPP)-4 inhibitors may promote serious arthralgia. However, the clinical evidence for this is relatively lacking...
  65. Suda M, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, et al. Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. PLoS ONE. 2017;12:e0182422 pubmed publisher
    ..We found that linagliptin, a DPP-4 inhibitor, suppressed capillary rarefaction in the hearts of mice with dietary obesity...
  66. Gantz I, Chen M, Suryawanshi S, Ntabadde C, Shah S, O Neill E, et al. A randomized, placebo-controlled study of the cardiovascular safety of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2017;16:112 pubmed publisher
    Omarigliptin is a once-weekly (q.w.) oral DPP-4 inhibitor that is approved for the treatment of patients with type 2 diabetes mellitus (T2DM) in Japan...
  67. Dean J, Hartsfield J, Wright J, Hart T. Dentin dysplasia, type II linkage to chromosome 4q. J Craniofac Genet Dev Biol. 1997;17:172-7 pubmed
    ..1 cM, includes SPPI, D4S2691, D4S2690, D4S451, and D4S2456, and overlaps the most likely location of the DGII locus. A candidate gene for DGII should also be considered a candidate gene for dentin dysplasia, type II. ..
  68. Haspel A, Giguere S, Hart K, Berghaus L, Davis J. Bioavailability and tolerability of nebulised dexamethasone sodium phosphate in adult horses. Equine Vet J. 2018;50:85-90 pubmed publisher
    Nebulisation of the injectable dexamethasone sodium phosphate (DSP) would offer an inexpensive way of delivering a potent corticosteroid directly to the lungs of horses with asthma...
  69. Diniz C, Rodrigues M, Casarotto P, Pereira V, Crestani C, Joca S. Monoamine involvement in the antidepressant-like effect induced by P2 blockade. Brain Res. 2017;1676:19-27 pubmed publisher
    ..Next, the effects of depleting serotonin and noradrenaline levels, by means of PCPA (p-Chlorophenylalanine) or DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride) pretreatment, respectively, was investigated...
  70. Pan L, Chen J, Shen H, He X, Li G, Song X, et al. Profiling of Extracellular Toxins Associated with Diarrhetic Shellfish Poison in Prorocentrum lima Culture Medium by High-Performance Liquid Chromatography Coupled with Mass Spectrometry. Toxins (Basel). 2017;9: pubmed publisher
    ..characterization and quantification of extracellular toxin compounds associated with diarrhetic shellfish poison (DSP) in the culture medium of toxin-producing dinoflagellates were performed using high-performance liquid ..
  71. Colice G, Price D, Gerhardsson de Verdier M, Rabon Stith K, Ambrose C, Cappell K, et al. The effect of DPP-4 inhibitors on asthma control: an administrative database study to evaluate a potential pathophysiological relationship. Pragmat Obs Res. 2017;8:231-240 pubmed publisher
    b>DPP-4 may regulate immunological pathways implicated in asthma...
  72. Papagerakis P, Berdal A, Mesbah M, Peuchmaur M, Malaval L, Nydegger J, et al. Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth. Bone. 2002;30:377-85 pubmed
    ..of bone and dentin, osteocalcin (OC) and osteonectin (ON), in comparison to the dentin-specific protein, dentin sialophosphoprotein (DSPP)...
  73. Roy S, Huang H, Liu S, Kornberg T. Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein. Science. 2014;343:1244624 pubmed publisher
    Decapentaplegic (Dpp), a Drosophila morphogen signaling protein, transfers directly at synapses made at sites of contact between cells that produce Dpp and cytonemes that extend from recipient cells...
  74. Yang R, Lim G, Yee C, Fuller R, Ritchie H. Site specificity of DSP-PP cleavage by BMP1. Connect Tissue Res. 2014;55 Suppl 1:142-5 pubmed publisher
    ..site; P4P3P2P1|P1'P2'P3'P4') sequence homologies between two BMP1 substrates, dentin matrix protein 1 and dentin sialoprotein phosphophoryn (DSP-PP) (i.e. xMQx|DDP), no direct testing has so far been attempted...
  75. Tang Y, Geng Q, Chen D, Zhao S, Liu X, Wang Z. Germline Proliferation Is Regulated by Somatic Endocytic Genes via JNK and BMP Signaling in Drosophila. Genetics. 2017;206:189-197 pubmed publisher
    ..We demonstrated that this nonautonomous effect was mediated by the transcriptional activation of Dpp [the fly homolog of bone morphogenetic protein (BMP)] by examining the Dpp-reporter expression and knocking down ..
  76. Kathe N, Shah A, Said Q, Painter J. DPP-4 Inhibitor-Induced Rheumatoid Arthritis Among Diabetics: A Nested Case-Control Study. Diabetes Ther. 2018;9:141-151 pubmed publisher
    The risk of rheumatoid arthritis (RA) associated with dipeptidyl peptidase-4 inhibitor (DPP-4i) use is unclear. This study assesses the RA risk associated with DPP-4i use among a diabetic cohort initiating second-line therapy...
  77. Hirose M, Takano H, Hasegawa H, Tadokoro H, Hashimoto N, Takemura G, et al. The effects of dipeptidyl peptidase-4 on cardiac fibrosis in pressure overload-induced heart failure. J Pharmacol Sci. 2017;135:164-173 pubmed publisher
    Dipeptidyl peptidase-4 (DPP-4) inhibitors are hypoglycemic agents. DPP-4 inhibitor has cardioprotective effects after transverse aortic constriction (TAC), but role of DPP-4 on cardiac fibrosis after TAC is not well known...
  78. Patel B, Bhadada S, Ghate M. Design, synthesis and anti-diabetic activity of triazolotriazine derivatives as dipeptidyl peptidase-4 (DPP-4) inhibitors. Bioorg Chem. 2017;72:345-358 pubmed publisher
    ..Inhibition of the enzyme, dipeptidyl peptidase-4 (DPP-4) has been proved as successful and safe therapy for the treatment of T2DM since last decade...
  79. Wong F, Ariff A, Stuckey D. Downstream protein separation by surfactant precipitation: a review. Crit Rev Biotechnol. 2018;38:31-46 pubmed publisher
    In a conventional protein downstream processing (DSP) scheme, chromatography is the single most expensive step...
  80. Piper C, Marossy A, Griffiths Z, Adegboye A. Evaluation of a type 2 diabetes prevention program using a commercial weight management provider for non-diabetic hyperglycemic patients referred by primary care in the UK. BMJ Open Diabetes Res Care. 2017;5:e000418 pubmed publisher
    To determine if a diabetes prevention program (DPP) delivered by a commercial weight management provider using a UK primary care referral pathway could reduce the progression to type 2 diabetes (T2D) in those diagnosed with non-diabetic ..
  81. Venditti E, Bray G, Carrion Petersen M, Delahanty L, Edelstein S, Hamman R, et al. First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes. Int J Obes (Lond). 2008;32:1537-44 pubmed publisher
    Following unblinding of the Diabetes Prevention Program (DPP) results, a 16-session lifestyle intervention program was offered to all study participants, including those who had initially been randomized to lifestyle treatment...
  82. Xie H, Zeng S, He Y, Zhang G, Yu P, Zhong G, et al. Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation. Eur J Med Chem. 2017;141:519-529 pubmed publisher
    ..In our continuous effort to find better glucose-lowering agents, an exploration for long-acting DPP-4 inhibitors had been launched...
  83. Chen D, Huang X, Gan H, Du X, Lu S, Huang R, et al. Efficacy of alogliptin combined with motor imagery under hyperbaric oxygen in diabetic nephropathy with silent cerebral infarction. Biomed Rep. 2017;7:407-415 pubmed publisher
    In the present study, we evaluated the curative effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor alogliptin combined with motor imagery under hyperbaric oxygen in diabetic nephropathy (DN) with silent cerebral infarction (SCI)...
  84. Baptista A, Teixeira I, Romano S, Carneiro A, Perelman J. The place of DPP-4 inhibitors in the treatment algorithm of diabetes type 2: a systematic review of cost-effectiveness studies. Eur J Health Econ. 2017;18:937-965 pubmed publisher
    To conduct a systematic review of cost-effectiveness, cost-utility, and cost-benefit studies of DPP-4 inhibitors for diabetes treatment versus other antidiabetics...
  85. Ariffin S, Manogaran T, Abidin I, Wahab R, Senafi S. A Perspective on Stem Cells as Biological Systems that Produce Differentiated Osteoblasts and Odontoblasts. Curr Stem Cell Res Ther. 2017;12:247-259 pubmed publisher
    ..detected the expression of genes such as ALP, OCN, OPN, BMP2 and RUNX2 in osteoblasts and the expression of the DSPP gene in odontoblasts...
  86. Yang T, Shen M, Yu M, Huang Y, Chen C. Acute pancreatitis in patients with type 2 diabetes mellitus treated with dipeptidyl peptidase-4 inhibitors. J Food Drug Anal. 2016;24:450-454 pubmed publisher
    Dipeptidyl peptidase (DPP)-4 inhibitors are approved for use in monotherapy or in combination therapy for patients with type 2 diabetes mellitus for <1 decade...
  87. Sanz Y, Toldra F, Renault P, Poolman B. Specificity of the second binding protein of the peptide ABC-transporter (Dpp) of Lactococcus lactis IL1403. FEMS Microbiol Lett. 2003;227:33-8 pubmed
    ..of Lactococcus lactis IL1403 revealed the presence of a putative peptide-binding protein-dependent ABC-transporter (Dpp)...
  88. Majithia A, Jablonski K, McAteer J, Mather K, Goldberg R, Kahn S, et al. Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program. Diabetologia. 2011;54:2570-4 pubmed publisher
    ..In the Diabetes Prevention Program (DPP), increased proinsulin levels predicted type 2 diabetes and proinsulin levels were significantly reduced following ..
  89. Chambers E, Rehm C, Correra J, Garcia L, Marquez M, Wylie Rosett J, et al. Factors in Placement and Enrollment of Primary Care Patients in YMCA's Diabetes Prevention Program, Bronx, New York, 2010-2015. Prev Chronic Dis. 2017;14:E28 pubmed publisher
    The reach of the New York State YMCA's Diabetes Prevention Program (DPP) to at-risk populations may be increased through integration with primary care settings...
  90. Hussain M, Atif M, Tunio A, Ali B, Akhtar L, Serwar G. Effect Of Sitagliptin On Glycemic Control, Body Weight, Blood Pressure And Serum Lipid Profile In Type 2 Diabetic Hyperlipidemic Patients. J Ayub Med Coll Abbottabad. 2016;28:369-372 pubmed
    ..The objective of the study was to assess the effect of sitagliptin a (DPP-4 inhibitor) oral antidiabetic drug on blood sugar, body weight, blood pressure and dyslipidaemia in type 2 ..
  91. Naveen J, Baskaran V. Antidiabetic plant-derived nutraceuticals: a critical review. Eur J Nutr. 2018;57:1275-1299 pubmed publisher
    ..Critical DM targets include α-amylase, α-glucosidase, DPP-IV, aldose reductase, PPAR-γ, AMP kinase and GLUT4...
  92. Hiromura M, Nohtomi K, Mori Y, Kataoka H, Sugano M, Ohnuma K, et al. Caveolin-1, a binding protein of CD26, is essential for the anti-inflammatory effects of dipeptidyl peptidase-4 inhibitors on human and mouse macrophages. Biochem Biophys Res Commun. 2018;495:223-229 pubmed publisher
    We previously reported that inhibition of dipeptidyl peptidase (DPP)-4, the catalytic site of CD26, prevents atherosclerosis in animal models through suppression of inflammation; however, the underlying molecular mechanisms have not been ..