dsg3

Summary

Gene Symbol: dsg3
Description: desmoglein 3
Alias: CDHF6, PVA, desmoglein-3, 130 kDa pemphigus vulgaris antigen, cadherin family member 6
Species: human
Products:     dsg3

Top Publications

  1. Amagai M, Klaus Kovtun V, Stanley J. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 1991;67:869-77 pubmed
    ..skin disease in which autoantibodies against a keratinocyte cell surface 130 kd glycoprotein, PV antigen (PVA), cause loss of cell-cell adhesion, with resultant epidermal blisters...
  2. Schafer S, Koch P, Franke W. Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins. Exp Cell Res. 1994;211:391-9 pubmed
    ..By contrast, the epidermal isoforms Dsg1 and Dsg3 are restricted to certain specialized epithelia, mostly stratified squamous ones...
  3. Yamamoto Y, Aoyama Y, Shu E, Tsunoda K, Amagai M, Kitajima Y. Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity. J Biol Chem. 2007;282:17866-76 pubmed
    ..by the loss of cell-cell adhesion between epidermal keratinocytes and the presence of autoantibody against desmoglein 3 (Dsg3), which provides adhesive integrity to desmosomes between adjacent keratinocytes...
  4. Kanno M, Isa Y, Aoyama Y, Yamamoto Y, Nagai M, Ozawa M, et al. P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3. Exp Cell Res. 2008;314:1683-92 pubmed publisher
    ..To determine which region is involved in the association between Dsg3 and p120ctn, we constructed mutant Dsg3 proteins, in which various cytoplasmic subdomains were removed...
  5. Tsang S, Liu L, Teh M, Wheeler A, Grose R, Hart I, et al. Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. PLoS ONE. 2010;5:e14211 pubmed publisher
    b>Desmoglein 3 (Dsg3), a desmosomal adhesion protein, is expressed in basal and immediate suprabasal layers of skin and across the entire stratified squamous epithelium of oral mucosa...
  6. Wu H, Stanley J, Cotsarelis G. Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. J Invest Dermatol. 2003;120:1052-7 pubmed
    ..We found that the expression pattern of desmoglein 3 correlated with different types of keratinization...
  7. Wan H, Stone M, Simpson C, Reynolds L, Marshall J, Hart I, et al. Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes. J Cell Sci. 2003;116:4239-48 pubmed
    ..We then showed that a low desmoglein 3 (Dsg3) expression on the cell surface could be used to enrich for a cell population with high clonogenecity, ..
  8. Chen Y, Chang J, Lee L, Wang H, Liao C, Chiu C, et al. DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis. Oncogene. 2007;26:467-76 pubmed
    ..Using reverse transcription-polymerase chain reaction and Western blot analysis, desmoglein 3 (DSG3) was identified as being differentially expressed at both the RNA and protein levels...
  9. Wan H, Yuan M, Simpson C, Allen K, Gavins F, Ikram M, et al. Stem/progenitor cell-like properties of desmoglein 3dim cells in primary and immortalized keratinocyte lines. Stem Cells. 2007;25:1286-97 pubmed
    We showed previously that primary keratinocytes selected for low desmoglein 3 (Dsg3) expression levels exhibited increased colony-forming efficiency and heightened proliferative potential relative to cells with higher Dsg3 expression ..

More Information

Publications111 found, 100 shown here

  1. Mannan T, Jing S, Foroushania S, Fortune F, Wan H. RNAi-mediated inhibition of the desmosomal cadherin (desmoglein 3) impairs epithelial cell proliferation. Cell Prolif. 2011;44:301-10 pubmed publisher
    b>Desmoglein 3 (Dsg3) is a desmosomal adhesion protein expressed in basal and immediate suprabasal layers of skin...
  2. Calkins C, Setzer S, Jennings J, Summers S, Tsunoda K, Amagai M, et al. Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies. J Biol Chem. 2006;281:7623-34 pubmed
    ..vulgaris (PV) is an autoimmune disorder in which antibodies are directed against the desmosomal adhesion molecule Dsg3, resulting in severe mucosal erosions and epidermal blistering...
  3. Spindler V, Drenckhahn D, Zillikens D, Waschke J. Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3. Am J Pathol. 2007;171:906-16 pubmed
    ..Because we recently demonstrated that pemphigus-IgG causes epidermal splitting by inhibition of Rho A, we propose that Rho GTPase inactivation contributes to the mechanisms accounting for the cleavage plane in pemphigus skin splitting. ..
  4. Heupel W, Zillikens D, Drenckhahn D, Waschke J. Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction. J Immunol. 2008;181:1825-34 pubmed
    ..These data demonstrate that PV-IgG and PF-IgG reduce Dsg transinteraction by cell-dependent mechanisms and suggest that in addition, Abs to Dsg 3 contribute to PV by direct inhibition of Dsg transinteraction. ..
  5. Spindler V, Endlich A, Hartlieb E, Vielmuth F, Schmidt E, Waschke J. The extent of desmoglein 3 depletion in pemphigus vulgaris is dependent on Ca(2+)-induced differentiation: a role in suprabasal epidermal skin splitting?. Am J Pathol. 2011;179:1905-16 pubmed publisher
    ..Depletion of Dsg3 is a critical mechanism in PV pathogenesis...
  6. Roh J, Stanley J. Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment. J Invest Dermatol. 1995;104:720-4 pubmed
    Desmogleins are transmembrane desmosomal cadherins. Two desmogleins, Dsg3 and Dsg1, have been shown to bind plakoglobin, an intracytoplasmic (IC) desmosomal plaque protein. This binding may be critical for desmosome assembly or stability...
  7. Andl C, Stanley J. Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes. J Invest Dermatol. 2001;117:1068-74 pubmed
    ..In this study we wanted to determine whether the carboxy- terminal cytoplasmic domains of desmoglein 3 are important for targeting it to the desmosome...
  8. Wang L, Liu T, Wang Y, Cao L, Nishioka M, Aguirre R, et al. Altered expression of desmocollin 3, desmoglein 3, and beta-catenin in oral squamous cell carcinoma: correlation with lymph node metastasis and cell proliferation. Virchows Arch. 2007;451:959-66 pubmed
    Desmocollin 3 (Dsc3) and desmoglein 3 (Dsg3) are both transmembrane glycoproteins that belong to the cadherin family of calcium-dependent cell adhesion molecules...
  9. Delva E, Jennings J, Calkins C, Kottke M, Faundez V, Kowalczyk A. Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism. J Biol Chem. 2008;283:18303-13 pubmed publisher
    ..The autoantibodies generated target the desmosomal cadherin desmoglein-3 (Dsg3)...
  10. Tsang S, Brown L, Lin K, Liu L, Piper K, O Toole E, et al. Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol. 2012;227:81-93 pubmed publisher
    ..Recently we reported that a desmosomal cadherin, desmoglein 3 (Dsg3), an autoantigen in pemphigus vulgaris (PV), associates with E-cadherin and activates Src, which results ..
  11. Merritt A, Berika M, Zhai W, Kirk S, Ji B, Hardman M, et al. Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation. Mol Cell Biol. 2002;22:5846-58 pubmed
    ..1 (Dsc1) isoforms of the desmosomal cadherins are expressed in the suprabasal layers of epidermis, whereas Dsg3 and Dsc3 are more strongly expressed basally...
  12. Fukuoka J, Dracheva T, Shih J, Hewitt S, Fujii T, Kishor A, et al. Desmoglein 3 as a prognostic factor in lung cancer. Hum Pathol. 2007;38:276-83 pubmed
    b>Desmoglein 3 is a desmosomal protein of the cadherin family...
  13. Heupel W, Muller T, Efthymiadis A, Schmidt E, Drenckhahn D, Waschke J. Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus. J Biol Chem. 2009;284:8589-95 pubmed publisher
    ..Therefore, we modeled the Dsg1 and Dsg3 sequences into resolved cadherin structures and predicted peptides targeting the adhesive interface of both Dsg3 ..
  14. Savci Heijink C, Kosari F, Aubry M, Caron B, Sun Z, Yang P, et al. The role of desmoglein-3 in the diagnosis of squamous cell carcinoma of the lung. Am J Pathol. 2009;174:1629-37 pubmed publisher
    ..Results from several microarray-based studies have led to the identification of up-regulated expression levels of the DSG3 gene in pulmonary squamous cell carcinomas (SQCCs)...
  15. Jolly P, Berkowitz P, Bektas M, Lee H, Chua M, Diaz L, et al. p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis. J Biol Chem. 2010;285:8936-41 pubmed publisher
    Pemphigus vulgaris (PV) is an autoimmune blistering disease in which antibodies against the desmosomal cadherin, DSG3 (desmoglein-3), cause acantholysis...
  16. Di Zenzo G, Amber K, Sayar B, Müller E, Borradori L. Immune response in pemphigus and beyond: progresses and emerging concepts. Semin Immunopathol. 2016;38:57-74 pubmed publisher
    ..Finally, adoptive transfer of splenocytes from Dsg3-knockout mice immunized with murine Dsg3 into immunodeficient mice phenotypically recapitulates PV...
  17. Pollmann R, Schmidt T, Eming R, Hertl M. Pemphigus: a Comprehensive Review on Pathogenesis, Clinical Presentation and Novel Therapeutic Approaches. Clin Rev Allergy Immunol. 2018;54:1-25 pubmed publisher
    ..Specifically, IgG against the desmosomal adhesion proteins, desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), preferentially target their ectodomains which are presumably critical for the ..
  18. Stahley S, Warren M, Feldman R, Swerlick R, Mattheyses A, Kowalczyk A. Super-Resolution Microscopy Reveals Altered Desmosomal Protein Organization in Tissue from Patients with Pemphigus Vulgaris. J Invest Dermatol. 2016;136:59-66 pubmed publisher
    ..epidermal blistering disease in which autoantibodies (IgG) are directed against the desmosomal cadherin desmoglein 3. To better understand how PV IgG alters desmosome morphology and function in vivo, biopsies from patients with ..
  19. Ferris R, Stefanika P, Xi L, Gooding W, Seethala R, Godfrey T. Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsy. Laryngoscope. 2012;122:1020-30 pubmed publisher
    ..the marker screen, the two most promising markers of SCCHN metastasis in the test set, pemphigus vulgaris antigen (PVA) and tumor-associated calcium signal transducer 1 (TACSTD1), also known as epithelial cell adhesion molecule (EpCAM)..
  20. Luyet C, Schulze K, Sayar B, Howald D, Müller E, Galichet A. Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris. PLoS ONE. 2015;10:e0119809 pubmed publisher
    ..The disease is caused by auto-antibodies that bind to desmosomal cadherins desmoglein (Dsg) 3 or Dsg3 and Dsg1 in mucous membranes and skin...
  21. Amber K, Valdebran M, Grando S. Paraneoplastic autoimmune multiorgan syndrome (PAMS): Beyond the single phenotype of paraneoplastic pemphigus. Autoimmun Rev. 2018;17:1002-1010 pubmed publisher
    ..Antibodies against desmoglein 3 (Dsg3) map to a broader array of epitopes than in pemphigus vulgaris and there is a higher prevalence of ..
  22. Joshi N, Minz R, Anand S, Parmar N, Kanwar A. Vitamin D deficiency and lower TGF-?/IL-17 ratio in a North Indian cohort of pemphigus vulgaris. BMC Res Notes. 2014;7:536 pubmed publisher
    ..Thus, there is a need to further evaluate the Treg/Th-17 axis, as it may have an important role in disease progression. ..
  23. Waschke J. Desmogleins as signaling hubs regulating cell cohesion and tissue/organ function in skin and heart - EFEM lecture 2018. Ann Anat. 2018;: pubmed publisher
    ..for loss of keratinocyte cohesion and have characterized a first disease-relevant adhesion receptor consisting of Dsg3 and p38MAPK...
  24. Kountikov E, Poe J, Maclver N, Rathmell J, Tedder T. A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. Am J Pathol. 2015;185:617-30 pubmed publisher
    b>Desmoglein 3 is a transmembrane component of desmosome complexes that mediate epidermal cell-to-cell adhesion and tissue integrity...
  25. Kiro A, Bajpai J, Bajpai A. Designing of silk and ZnO based antibacterial and noncytotoxic bionanocomposite films and study of their mechanical and UV absorption behavior. J Mech Behav Biomed Mater. 2017;65:281-294 pubmed publisher
    Bionanocomposites of sericin and polyvinyl alcohol (PVA) were prepared by solution casting method and zinc oxide nanoparticles were impregnated within the polymer blend matrix through homogenous phase reaction between zinc chloride and ..
  26. Gornowicz Porowska J, Seraszek Jaros A, Bowszyc Dmochowska M, Kaczmarek E, Pietkiewicz P, Bartkiewicz P, et al. A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses. Pol J Pathol. 2017;68:109-116 pubmed publisher
    ..expression in relation to the neutrophil elastase (NE) expression and serum level of anti-desmoglein 1 and 3 (DSG1/DSG3) IgG in pemphigus, anti-BP180/BP230 IgG in bullous pemphigoid (BP), anti-gliadin nonapeptides (npG), tissue (tTG), ..
  27. Agackiran Y, Ozcan A, Akyurek N, Memis L, Findik G, Kaya S. Desmoglein-3 and Napsin A double stain, a useful immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes. Appl Immunohistochem Mol Morphol. 2012;20:350-5 pubmed publisher
    ..The use of a desmoglein-3 and Napsin A double-staining strategy in our study confirmed that these markers are useful in differentiating pulmonary squamous cell carcinoma and pulmonary adenocarcinoma from other subtypes. ..
  28. Fernández Rodríguez O, Ríos A, Palenciano C, Ramírez P, Navarro J, Martínez Alarcón L, et al. A hemodynamic, metabolic and histopathological study of a heterotopic auxiliary swine liver graft with portal vein arterialization. Cir Esp. 2016;94:77-85 pubmed publisher
    Auxiliary heterotopic liver transplantation with portal vein arterialization (AHLT-PVA) is a model that has been hardly studied, despite its therapeutic potential...
  29. Mahmoodi N, Mokhtari Shourijeh Z, Ghane Karade A. Synthesis of the modified nanofiber as a nanoadsorbent and its dye removal ability from water: isotherm, kinetic and thermodynamic. Water Sci Technol. 2017;75:2475-2487 pubmed publisher
    In this paper, poly(vinyl alcohol) (PVA) nanofiber was prepared and modified by diethylenetriamine (DETA) and ethylenediamine (EDA) in the presence of glutaraldehyde (GA)...
  30. Cheng Y, Chang Y, Chen W, Shih H, Chen Y, Shyu B, et al. Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus. Nat Commun. 2017;8:826 pubmed publisher
    ..infarction is reduced, and this cardioprotection is induced via an anterior nucleus of paraventricular thalamus (PVA)-dependent parasympathetic pathway...
  31. Ajovalasit A, Sabatino M, Todaro S, Alessi S, Giacomazza D, Picone P, et al. Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships. Carbohydr Polym. 2018;179:262-272 pubmed publisher
    ..Polyvinyl alcohol (PVA) and glycerol (Gro) were added to have an optimal combination of softness, conformability and resilience...
  32. Hoover H, Li J, Marchese J, Rothwell C, Borawoski J, Jeffery D, et al. Quantitative Proteomic Verification of Membrane Proteins as Potential Therapeutic Targets Located in the 11q13 Amplicon in Cancers. J Proteome Res. 2015;14:3670-9 pubmed publisher
    ..We found that DSG3, CD109, and CD14 were differentially overexpressed in head and neck and breast tumor cells with 11q13 amplification...
  33. Lewandowska K. Characterization of chitosan composites with synthetic polymers and inorganic additives. Int J Biol Macromol. 2015;81:159-64 pubmed publisher
    ..of polymer composites containing chitosan (Ch) and montmorillonite (MMT) with and without poly(vinyl alcohol) (PVA) are presented...
  34. Akhil K, Jayakumar J, Gayathri G, Khan S. Effect of various capping agents on photocatalytic, antibacterial and antibiofilm activities of ZnO nanoparticles. J Photochem Photobiol B. 2016;160:32-42 pubmed publisher
    ..with and without the use of surface modifying agents including ethylene glycol (EG), gelatin, polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP). Preliminary characterization was done by UV-Visible spectroscopy...
  35. Knopp M, Chourak N, Khan F, Wendelboe J, Langguth P, Rades T, et al. Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions. Eur J Pharm Biopharm. 2016;105:106-14 pubmed publisher
    ..behavior and in vivo performance in rats of celecoxib (CCX) amorphous solid dispersions with polyvinyl acetate (PVA), polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC) at different drug doses...
  36. Cho M, Ellebrecht C, Hammers C, Mukherjee E, Sapparapu G, Boudreaux C, et al. Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6. J Immunol. 2016;197:1065-73 pubmed publisher
    Shared VH1-46 gene usage has been described in B cells reacting to desmoglein 3 (Dsg3) in the autoimmune disease pemphigus vulgaris (PV), as well as B cells responding to rotavirus capsid protein VP6...
  37. Mishra S, Teotia A, Kumar A, Kannan S. Mechanically tuned nanocomposite coating on titanium metal with integrated properties of biofilm inhibition, cell proliferation, and sustained drug delivery. Nanomedicine. 2017;13:23-35 pubmed publisher
    ..To this aim, a nanohybrid of silver nanoparticles (AgNPs) cored in polyvinyl alcohol nanocapsules (Ag-PVA NCs) embedded in chitosan (CS) matrix loaded with anti-inflammatory drug naproxen was prepared...
  38. Suktham K, Koobkokkruad T, Saesoo S, Saengkrit N, Surassmo S. Physical and biological characterization of sericin-loaded copolymer liposomes stabilized by polyvinyl alcohol. Colloids Surf B Biointerfaces. 2016;148:487-495 pubmed publisher
    ..value to wastewater from the silk industry, sericin protein was recovered as sericin-loaded copolymer-liposomes (SP-PVA-LP), prepared through thin film hydration...
  39. Chang S, Wu C, Wang R, Lin C. Electricity production and benzene removal from groundwater using low-cost mini tubular microbial fuel cells in a monitoring well. J Environ Manage. 2017;193:551-557 pubmed publisher
    ..Additionally, a thinner polyvinyl alcohol (PVA) hydrogel separator and PVA with a higher molecular weight improved electricity generation...
  40. Tolessa T, Zhou X, Amde M, Liu J. Development of reusable magnetic chitosan microspheres adsorbent for selective extraction of trace level silver nanoparticles in environmental waters prior to ICP-MS analysis. Talanta. 2017;169:91-97 pubmed publisher
    ..for 11 blank readings), for three AgNPs coated with polyvinyl pyrrolidone (PVP), citrate and polyvinyl alcohol (PVA) and sizes of 31, 40, 46nm, respectively, were in the range of 0.016?0.023?g/L...
  41. Yuan H, Zhou S, Liu Z, Cong W, Fei X, Zeng W, et al. Pivotal Role of Lesional and Perilesional T/B Lymphocytes in Pemphigus Pathogenesis. J Invest Dermatol. 2017;137:2362-2370 pubmed publisher
    ..In addition, a significantly increased number of Dsg1- and Dsg3-specific B cells could be identified by flow cytometric analysis or enzyme-linked immunospot technique (i.e...
  42. Åhlén M, Tummala G, Mihranyan A. Nanoparticle-loaded hydrogels as a pathway for enzyme-triggered drug release in ophthalmic applications. Int J Pharm. 2018;536:73-81 pubmed publisher
    ..drug delivery were developed by incorporating chitosan-poly (acrylic acid) nanoparticles into polyvinyl alcohol (PVA) hydrogels and in-situ gelled nanoparticles and cellulose nanocrystals (CNC) in PVA lenses...
  43. Coukouma A, Smith N, Asher S. Removable interpenetrating network enables highly-responsive 2-D photonic crystal hydrogel sensors. Analyst. 2015;140:6517-21 pubmed publisher
    ..We demonstrate the utility of this approach by incorporating an interpenetrating PVA hydrogel within a weak, low crosslinked pH sensitive hydrogel through a freeze-thaw process...
  44. Boulila S, Oudadesse H, Badraoui R, Lefeuvre B, Mabrouk M, Chaabouni K, et al. Antioxidative/oxidative effects and retarding osteoconductivity of ciprofloxacin-loaded porous polyvinyl alcohol/bioactive glass hybrid. Med Biol Eng Comput. 2017;55:17-32 pubmed publisher
    This study investigated the effect of bioglass (melting)-polyvinyl alcohol (BG (M)-PVA) and bioglass (melting)-polyvinyl alcohol-20 %ciprofloxacin (BG(M)-PVA-20Cip) in improving antioxidant activity and regenerating bone capacity...
  45. Tan Z, Wang H, Gao X, Liu T, Tan Y. Composite vascular grafts with high cell infiltration by co-electrospinning. Mater Sci Eng C Mater Biol Appl. 2016;67:369-377 pubmed publisher
    ..We fabricated grafts made of polycaprolactone, gelatin, and polyvinyl alcohol (PVA) by co-electrospinning, and the scaffolds were further functionalized by immobilizing heparin on them...
  46. Markl D, Zeitler J, Rasch C, Michaelsen M, Mullertz A, Rantanen J, et al. Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging. Pharm Res. 2017;34:1037-1052 pubmed publisher
    ..Printing was performed with either polyvinyl alcohol (PVA) or polylactic acid (PLA). The structures were examined by X?CT and TPI...
  47. Meshram J, Koli V, Phadatare M, Pawar S. Anti-microbial surfaces: An approach for deposition of ZnO nanoparticles on PVA-Gelatin composite film by screen printing technique. Mater Sci Eng C Mater Biol Appl. 2017;73:257-266 pubmed publisher
    ..Therefore, herein, we attempt screen printing technique for development of PVA-GE/ZnO nanocomposite (PG/ZnO) films...
  48. Moreau D, Villain A, Bachy M, Proudhon H, Ku D, Hannouche D, et al. In vivo evaluation of the bone integration of coated poly(vinyl-alcohol) hydrogel fiber implants. J Mater Sci Mater Med. 2017;28:114 pubmed publisher
    Recently, it has been shown that constructs of poly(vinyl alcohol) (PVA) hydrogel fibers reproduce closely the tensile behavior of ligaments. However, the biological response to these systems has not been explored yet...
  49. Mastrangelo R, Montis C, Bonelli N, Tempesti P, Baglioni P. Surface cleaning of artworks: structure and dynamics of nanostructured fluids confined in polymeric hydrogel networks. Phys Chem Chem Phys. 2017;19:23762-23772 pubmed publisher
    ..In this study PVA hydrogels, obtained via freeze-thaw processes, are prepared as scaffolds for water-based nanostructured fluids for ..
  50. Ma Q, Liang T, Cao L, Wang L. Intelligent poly (vinyl alcohol)-chitosan nanoparticles-mulberry extracts films capable of monitoring pH variations. Int J Biol Macromol. 2018;108:576-584 pubmed publisher
    The aim of this study was to prepare a visually responsive intelligent film based on poly (vinyl alcohol) (PVA), chitosan nanoparticles (CHNPs) and mulberry extracts (MBE)...
  51. Strehl C, Schellmann S, Maurizi L, Hofmann Amtenbrink M, Häupl T, Hofmann H, et al. Effects of PVA-coated nanoparticles on human T helper cell activity. Toxicol Lett. 2016;245:52-8 pubmed publisher
    ..Since we could demonstrate that professional phagocytes are activated by amino-polyvinyl-alcohol-coated-SPION (a-PVA-SPION), the study here focuses on the influence of a-PVA-SPION on human T cells activity...
  52. El Sherbiny I, El Shibiny A, Salih E. Photo-induced green synthesis and antimicrobial efficacy of poly (?-caprolactone)/curcumin/grape leaf extract-silver hybrid nanoparticles. J Photochem Photobiol B. 2016;160:355-63 pubmed publisher
    ..PCL/Cur/GLE NPs were synthesized via emulsion-solvent evaporation in the presence of PVA as a capping agent, then used as active nano-supports for the green synthesis and stabilization of AgNPs on their ..
  53. Falath W, Sabir A, Jacob K. Novel reverse osmosis membranes composed of modified PVA/Gum Arabic conjugates: Biofouling mitigation and chlorine resistance enhancement. Carbohydr Polym. 2017;155:28-39 pubmed publisher
    A novel crosslinked Poly (vinyl alcohol) (PVA) reverse osmosis (RO) thin film membrane conjugated with Gum Arabic (GA) with superb performance and features was synthesized for water desalination...
  54. Asgher M, Ahmad Z, Iqbal H. Bacterial cellulose-assisted de-lignified wheat straw-PVA based bio-composites with novel characteristics. Carbohydr Polym. 2017;161:244-252 pubmed publisher
    ..bio-composites from a de-lignified and bacterially modified wheat straw in the presence of polyvinyl alcohol (PVA) and glycerol as a plasticizer...
  55. Wei Q, Wang Y, Li X, Yang M, Chai W, Wang K, et al. Study the bonding mechanism of binders on hydroxyapatite surface and mechanical properties for 3DP fabrication bone scaffolds. J Mech Behav Biomed Mater. 2016;57:190-200 pubmed publisher
    ..between binders and HA surface is consistent with the cohesive energy densities of binders, which is PAM/HA>PVA/HA>PVP/HA...
  56. Samanta A, Nandan B, Srivastava R. Morphology of electrospun fibers derived from High Internal Phase Emulsions. J Colloid Interface Sci. 2016;471:29-36 pubmed publisher
    ..In the present work, electrospinning of HIPEs formed from aqueous solution of poly(vinyl alcohol) (PVA) dispersed in continuous phase comprised of poly(ε-caprolactone) (PCL) solution in toluene is conducted...
  57. Gani K, Singh J, Singh N, Ali M, Rose V, Kazmi A. Nitrogen and carbon removal efficiency of a polyvinyl alcohol gel based moving bed biofilm reactor system. Water Sci Technol. 2016;73:1511-9 pubmed publisher
    In this study, the effectiveness of polyvinyl alcohol (PVA) gel beads in treating domestic wastewater was investigated: a moving bed biofilm reactor (MBBR) configuration (oxic-anoxic and oxic) with 10% filling fraction of biomass ..
  58. Schulze J, Hendrikx S, Schulz Siegmund M, Aigner A. Microparticulate poly(vinyl alcohol) hydrogel formulations for embedding and controlled release of polyethylenimine (PEI)-based nanoparticles. Acta Biomater. 2016;45:210-222 pubmed publisher
    ..and their corresponding liposome-modified analogues (lipopolyplexes), into microparticulate poly (vinyl alcohol) (PVA) hydrogels. Various parameters are modified, and major differences are found...
  59. Ashrafi K, Tang Y, Britton H, Domenge O, Blino D, Bushby A, et al. Characterization of a novel intrinsically radiopaque Drug-eluting Bead for image-guided therapy: DC Bead LUMIâ„¢. J Control Release. 2017;250:36-47 pubmed publisher
    We have developed a straightforward and efficient method of introducing radiopacity into Polyvinyl alcohol (PVA)-2-Acrylamido-2-methylpropane sulfonic acid (AMPS) hydrogel beads (DC Beadâ„¢) that are currently used in the clinic to ..
  60. Radosinski L, Labus K. Molecular modeling studies of structural properties of polyvinyl alcohol: a comparative study using INTERFACE force field. J Mol Model. 2017;23:305 pubmed publisher
    Polyvinyl alcohol (PVA) is a material with a variety of applications in separation, biotechnology, and biomedicine...
  61. Vail N, Stubbs C, Biggs C, Gibson M. Ultra-Low Dispersity Poly(vinyl alcohol) Reveals Significant Dispersity Effects on Ice Recrystallization Inhibition Activity. ACS Macro Lett. 2017;6:1001-1004 pubmed publisher
    ..Poly(vinyl alcohol), PVA, is the most potent polymeric ice growth inhibitor known, but its mode of action and the impact of valency (DP) are ..
  62. Zhang R, Zhang Q, Ji Y, Su F, Meng L, Qi Z, et al. Stretch-induced complexation reaction between poly(vinyl alcohol) and iodine: an in situ synchrotron radiation small- and wide-angle X-ray scattering study. Soft Matter. 2018;14:2535-2546 pubmed publisher
    Fibrillation and the complexation reaction between poly(vinyl alcohol) (PVA)-iodine (i) complexes have been studied with in situ synchrotron radiation small- and wide-angle X-ray scattering (SAXS and WAXS) during the uniaxial stretching ..
  63. Abdelgawad A, El Naggar M, Hudson S, Rojas O. Fabrication and characterization of bactericidal thiol-chitosan and chitosan iodoacetamide nanofibres. Int J Biol Macromol. 2017;94:96-105 pubmed publisher
    ..nanofibres mats from aqueous solutions could be crosslinked and achieved using polyvinyl alcohol/Chitosan blend (PVA/Cs) polymers...
  64. Stocco E, Barbon S, Lora L, Grandi F, Sartore L, Tiengo C, et al. Partially oxidized polyvinyl alcohol conduitfor peripheral nerve regeneration. Sci Rep. 2018;8:604 pubmed publisher
    ..Thus, its characteristics were compared with neat polyvinyl alcohol (PVA) and silk-fibroin (SF) conduits, through in vitro and in vivo analysis...
  65. Nardo B, Montalti R, Puviani L, Pacile V, Beltempo P, Bertelli R, et al. An experimental pilot study on controlled portal vein arterialization with an extracorporeal device in the swine model of partial liver resection and ischemia. Int J Artif Organs. 2006;29:912-8 pubmed
    ..physiologically oxygenated arterial blood reversed in the portal system by means of portal vein arterialization (PVA) through an extracorporeal device which we have called L.E.O2.NARDO (Liver Extracorporeal Oxygen...
  66. Brandt O, Rafei D, Podstawa E, Niedermeier A, Jonkman M, Terra J, et al. Differential IgG recognition of desmoglein 3 by paraneoplastic pemphigus and pemphigus vulgaris sera. J Invest Dermatol. 2012;132:1738-41 pubmed publisher
  67. Rötzer V, Hartlieb E, Vielmuth F, Gliem M, Spindler V, Waschke J. E-cadherin and Src associate with extradesmosomal Dsg3 and modulate desmosome assembly and adhesion. Cell Mol Life Sci. 2015;72:4885-97 pubmed publisher
    ..in this study the relationship between the classical cadherin E-cadherin and the desmosomal cadherin Desmoglein 3 (Dsg3), the latter of which is indispensable for cell-cell adhesion in keratinocytes...
  68. Arnemann J, Spurr N, Buxton R. The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18. Hum Genet. 1992;89:347-50 pubmed
    ..Genes coding for DGI (DSG1) and HDGC (DSG2) have previously been assigned to human chromosome 18. We now present evidence, using a polymerase chain reaction assay, that DSG3, the gene coding for PVA, is assigned to the same chromosome.
  69. Vielmuth F, Hartlieb E, Kugelmann D, Waschke J, Spindler V. Atomic force microscopy identifies regions of distinct desmoglein 3 adhesive properties on living keratinocytes. Nanomedicine. 2015;11:511-20 pubmed publisher
    ..of living human keratinocytes and the distribution and binding properties of the desmosomal adhesion molecule desmoglein 3 (Dsg3)...
  70. Popov A, Enlow E, Bourassa J, Chen H. Mucus-penetrating nanoparticles made with "mucoadhesive" poly(vinyl alcohol). Nanomedicine. 2016;12:1863-1871 pubmed publisher
    ..Contrary to the established opinion that poly(vinyl alcohol) (PVA) is mucoadhesive, we discovered that coating otherwise mucoadhesive nanoparticles with certain partially hydrolyzed ..
  71. Habiba U, Siddique T, Joo T, Salleh A, Ang B, Afifi A. Synthesis of chitosan/polyvinyl alcohol/zeolite composite for removal of methyl orange, Congo red and chromium(VI) by flocculation/adsorption. Carbohydr Polym. 2017;157:1568-1576 pubmed publisher
    A chitosan/polyvinyl alcohol (PVA)/zeolite composite was fabricated in this study...
  72. Niknia N, Kadkhodaee R. Gum tragacanth-polyvinyl alcohol cryogel and xerogel blends for oral delivery of silymarin: Structural characterization and mucoadhesive property. Carbohydr Polym. 2017;177:315-323 pubmed publisher
    In this study silymarin (SM) loaded cryo- and xerogels of gum tragacanth-polyvinyl alcohol (GT-PVA) were prepared and their physico-mechanical, microstructural and release properties were investigated...
  73. Huang X, Hou Y, Zhong L, Huang D, Qian H, Karperien M, et al. Promoted Chondrogenesis of Cocultured Chondrocytes and Mesenchymal Stem Cells under Hypoxia Using In-situ Forming Degradable Hydrogel Scaffolds. Biomacromolecules. 2018;19:94-102 pubmed publisher
    ..5% O2) on the chondrogenesis of different cell systems cultured in pH-degradable PVA hydrogels, including human articular chondrocytes (hACs), human mesenchymal stem cells (hMSCs), and their ..
  74. Szabados H, Uray K, Majer Z, Silló P, Kárpáti S, Hudecz F, et al. Characterization of desmoglein-3 epitope region peptides as synthetic antigens: analysis of their in vitro T cell stimulating efficacy, cytotoxicity, stability, and their conformational features. J Pept Sci. 2015;21:731-42 pubmed publisher
    Desmoglein-3 (Dsg3) adhesion protein is the main target of autoantibodies and autoreactive T cells in Pemphigus vulgaris (PV) autoimmune skin disorder...
  75. Choi J, Lee B. Bonding Properties of Basalt Fiber and Strength Reduction According to Fiber Orientation. Materials (Basel). 2015;8:6719-6727 pubmed publisher
    ..properties of basalt fiber such as slip-hardening coefficient and strength reduction coefficient were worse than PVA and polyethylene fibers in terms of fiber bridging capacity...
  76. Kyrodimou M, Andreadis D, Drougou A, Amanatiadou E, Angelis L, Barbatis C, et al. Desmoglein-3/?-catenin and E-cadherin/ß-catenin differential expression in oral leukoplakia and squamous cell carcinoma. Clin Oral Investig. 2014;18:199-210 pubmed publisher
    ..Expression of desmogleins-2,3 (Dsg2/Dsg3), E-cadherin, and their cytoplasmic ligand, ?/?-catenins were quantitatively assessed in HSC-3 cells growing as ..
  77. Trivedi S, Mattos J, Gooding W, Godfrey T, Ferris R. Correlation of tumor marker expression with nodal disease burden in metastatic head and neck cancer. Otolaryngol Head Neck Surg. 2013;149:261-8 pubmed publisher
    ..cell carcinoma of the head and neck (HNSCC) and level of expression of 3 marker genes: pemphigus vulgaris antigen (PVA), parathyroid hormone-related peptide (PTHrP), and tumor-associated calcium signal transducer 1 (TACSTD1)...
  78. Brown L, Waseem A, Cruz I, Szary J, Gunic E, Mannan T, et al. Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation. Oncogene. 2014;33:2363-74 pubmed publisher
    b>Desmoglein 3 (Dsg3), the pemphigus vulgaris antigen, has recently been shown to be upregulated in squamous cell carcinoma (SCC) and has been identified as a good tumor-specific marker for clinical staging of cervical sentinel lymph nodes ..
  79. Cella C, Gerges I, Milani P, Lenardi C, Argentiere S. Calcium Stearate as an Effective Alternative to Poly(vinyl alcohol) in Poly-Lactic-co-Glycolic Acid Nanoparticles Synthesis. Biomacromolecules. 2017;18:452-460 pubmed publisher
    ..and uniform PLGA NPs has involved the use of a large excess of polyvinyl surfactants such as poly(vinyl alcohol) (PVA) and polyvinylpyrrolidone (PVP), whose removal requires multistep purification procedures of high ecological and ..
  80. Leitão A, Silva J, Dourado F, Gama M. Production and Characterization of a New Bacterial Cellulose/Poly(Vinyl Alcohol) Nanocomposite. Materials (Basel). 2013;6:1956-1966 pubmed publisher
    ..of a new interpenetrated polymer network nanocomposite obtained through the incorporation of poly(vinyl alcohol) (PVA) on the BC matrix and evaluates the effect of oven drying on the morphological, mechanical and mass transfer ..
  81. Fu S, Tian H, Wei D, Zhang X, Liu Y. Delineating the Origins of Vibrio parahaemolyticus Isolated from Outbreaks of Acute Hepatopancreatic Necrosis Disease in Asia by the Use of Whole Genome Sequencing. Front Microbiol. 2017;8:2354 pubmed publisher
    ..Core genome analysis of pVA-1-like plasmid sequences from V...
  82. Morandim Giannetti A, Silva R, Magalhães O, Schor P, Bersanetti P. Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute. J Biomed Mater Res B Appl Biomater. 2016;104:1386-95 pubmed publisher
    ..were defined for obtaining a hydrogel with characteristics similar to the vitreous humor using polyvinyl alcohol (PVA) and trisodium trimetaphosphate (STMP)...
  83. Asim S, Wasim M, Sabir A, Shafiq M, Andlib H, Khuram S, et al. The effect of Nanocrystalline cellulose/Gum Arabic conjugates in crosslinked membrane for antibacterial, chlorine resistance and boron removal performance. J Hazard Mater. 2018;343:68-77 pubmed publisher
    ..integrated with Nanocrystalline cellulose (NCC)/Gum Arabic (GuA) conjugates using crosslinked Poly (vinyl alcohol) (PVA) as a matrix phase with the addition of PEO-PPO-PEO block copolymer that insured pore formation...
  84. Liu J, Pan D, Wu X, Chen H, Cao H, Li Q, et al. Enhanced degradation of prometryn and other s-triazine herbicides in pure cultures and wastewater by polyvinyl alcohol-sodium alginate immobilized Leucobacter sp. JW-1. Sci Total Environ. 2018;615:78-86 pubmed publisher
    ..Leucobacter sp. JW-1 cells were immobilized in polyvinyl alcohol?sodium alginate (PVA-SA) beads and then used to degrade prometryn...
  85. Lim G, Woo S, Lee H, Moon K, Sohn H, Lee S, et al. Mechanically Robust Magnetic Carbon Nanotube Papers Prepared with CoFe2O4 Nanoparticles for Electromagnetic Interference Shielding and Magnetomechanical Actuation. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..filtration of an aqueous suspension of CNTs, CoFe2O4 nanoparticles, and poly(vinyl alcohol) (PVA). PVA plays a critical role in enhancing the mechanical strength of CNT papers...
  86. Velásquez Cock J, Gómez H B, Posada P, Serpa G A, Gómez H C, Castro C, et al. Poly (vinyl alcohol) as a capping agent in oven dried cellulose nanofibrils. Carbohydr Polym. 2018;179:118-125 pubmed publisher
    ..The present work examines a new approach that involves using poly (vinyl alcohol) (PVA) as a capping agent to redisperse CNFs...
  87. Karpati S, Amagai M, Prussick R, Cehrs K, Stanley J. Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes. J Cell Biol. 1993;122:409-15 pubmed
    Pemphigus vulgaris antigen (PVA) is a member of the desmoglein subfamily of cadherin cell adhesion molecules...
  88. Kamiya K, Aoyama Y, Wakashima C, Kudo T, Nakajima K, Sano S, et al. Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3. J Dermatol. 2016;43:429-31 pubmed publisher
    ..with pemphigus vulgaris (PV), pathogenic immunoglobulin (Ig)G antibodies are most commonly directed against desmoglein 3 (Dsg3)...
  89. Chen K, Zhang D, Yang X, Cui X, Zhang X, Wang Q. Research on torsional friction behavior and fluid load support of PVA/HA composite hydrogel. J Mech Behav Biomed Mater. 2016;62:182-194 pubmed publisher
    ..This study aimed to investigate (1) the torsional friction contact state and the transformation mechanism of PVA/HA composite hydrogel against CoCrMo femoral head and (2) effects of load and torsional angle on torsional friction ..
  90. Swift T, Seaton C, Rimmer S. Poly(acrylic acid) interpolymer complexes. Soft Matter. 2017;13:8736-8744 pubmed publisher
    ..poly(ethylene oxide) (PEO); poly(dimethylacrylamide) (PDMA); poly(diethyl acrylamide) (PDEAM) poly(vinyl alcohol) (PVA) and poly(vinyl pyrolidinone) (PVP)...
  91. Schmidt T, Willenborg S, Hünig T, Deeg C, Sonderstrup G, Hertl M, et al. Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris. Exp Dermatol. 2016;25:293-8 pubmed publisher
    ..Its pathogenesis is based on IgG autoantibodies that target the desmosomal cadherins, desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1) and induce intra-epidermal loss of adhesion...
  92. Zhu H, Zhang Q, Zhu S. Assembly of a Metal-Organic Framework into 3?D Hierarchical Porous Monoliths Using a Pickering High Internal Phase Emulsion Template. Chemistry. 2016;22:8751-5 pubmed publisher
    ..Furthermore, by adding small amount of polyvinyl alcohol (PVA) as binder or polymerization in the continuous aqueous phase, followed by freeze-drying, two types of MOF-based 3D ..