Gene Symbol: DRPLA
Description: atrophin 1
Alias: B37, D12S755E, DRPLA, HRS, NOD, atrophin-1, dentatorubral-pallidoluysian atrophy protein
Species: human
Products:     DRPLA

Top Publications

  1. Wood J, Nucifora F, Duan K, Zhang C, Wang J, Kim Y, et al. Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription. J Cell Biol. 2000;150:939-48 pubmed
    Dentato-rubral and pallido-luysian atrophy (DRPLA) is one of the family of neurodegenerative diseases caused by expansion of a polyglutamine tract...
  2. Nucifora F, Ellerby L, Wellington C, Wood J, Herring W, Sawa A, et al. Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity. J Biol Chem. 2003;278:13047-55 pubmed
    Dentatorubral and pallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder similar to Huntington's disease, with clinical manifestations including chorea, incoordination, ataxia, and dementia...
  3. Yazawa I, Nukina N, Hashida H, Goto J, Yamada M, Kanazawa I. Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain. Nat Genet. 1995;10:99-103 pubmed
    Dentatorubral-pallidoluysian atrophy (DRPLA) is associated with the expansion of an unstable CAG repeat...
  4. Nagafuchi S, Yanagisawa H, Ohsaki E, Shirayama T, Tadokoro K, Inoue T, et al. Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA). Nat Genet. 1994;8:177-82 pubmed
    ..These results provide clues toward understanding neurodegenerative diseases associated with triplet repeat expansion. ..
  5. Nagafuchi S, Yanagisawa H, Sato K, Shirayama T, Ohsaki E, Bundo M, et al. Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p. Nat Genet. 1994;6:14-8 pubmed
    Dentatorubral and pallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder characterized by combined systemic degeneration of the dentatofugal and pallidofugal pathways...
  6. Koide R, Ikeuchi T, Onodera O, Tanaka H, Igarashi S, Endo K, et al. Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nat Genet. 1994;6:9-13 pubmed
    Hereditary dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant neurologic disorder characterized by variable combinations of myoclonus, epilepsy, cerebellar ataxia, choreoathetosis and dementia...
  7. Wang L, Rajan H, Pitman J, McKeown M, Tsai C. Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors. Genes Dev. 2006;20:525-30 pubmed
  8. Li S, McInnis M, Margolis R, Antonarakis S, Ross C. Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. Genomics. 1993;16:572-9 pubmed
  9. Wood J, Yuan J, Margolis R, Colomer V, Duan K, Kushi J, et al. Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol Cell Neurosci. 1998;11:149-60 pubmed
    ..contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy (DRPLA). The normal function of atrophin-1 is unknown...

More Information

Publications138 found, 100 shown here

  1. Farrell G, Haczeyni F, Chitturi S. Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. Adv Exp Med Biol. 2018;1061:19-44 pubmed publisher
    ..stimulate innate immunity by binding pattern recognition receptors, such as Toll-like receptor 4 (TLR4) and the NOD-like receptor protein 3 (NLRP3) inflammasome, which release a cascade of pro-inflammatory chemokines and cytokines...
  2. Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Fröhlich T, et al. Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. Hum Reprod. 2016;31:133-49 pubmed publisher
    ..SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4) and NOD-like receptor family pyrin domain containing 5 (NLRP5) also known as MATER), RNA-binding proteins (MSY2 also known ..
  3. Doss H, Dey C, Sudandiradoss C, Rasool M. Targeting inflammatory mediators with ferulic acid, a dietary polyphenol, for the suppression of monosodium urate crystal-induced inflammation in rats. Life Sci. 2016;148:201-10 pubmed publisher
    ..mRNA) expression of pro-inflammatory cytokines (TNF-α and IL-1β), NLRP3 (nucleotide oligomerization domain (NOD)-like receptor family, pyrin domain containing 3) inflammasomes, caspase-1, and the transcription factor nuclear ..
  4. Dusséaux M, Masse Ranson G, Darche S, Ahodantin J, Li Y, Fiquet O, et al. Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver. Gastroenterology. 2017;153:1647-1661.e9 pubmed publisher
    ..We performed studies with BALB/c Rag2-/-Il2rg-/-SirpaNODAlb-uPAtg/tg mice, stably engrafted with human hepatocytes (HUHEP) with or without a human immune ..
  5. Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, et al. Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis. Front Immunol. 2018;9:1197 pubmed publisher
    ..Expression of several inflammasome components, the NOD-like receptor (NLR) family pyrin domain containing 1 (NLRP1), NLRP3, CARD-domain containing 4 (NLRC4), absent in ..
  6. Li Z, Yan Z, Lan F, Dong Y, Xiong Y. Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice. Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..Western blot analysis suggested that NLGN3-knockout inhibited the activation of nod-like receptor protein 3 (NLRP3) inflammasome and its adaptor of apoptosis-associated speck like protein (ASC), and ..
  7. Jia K, Pan S, Ding H, Liu J, Zheng Y, Wang S, et al. Chaihu-shugan san inhibits inflammatory response to improve insulin signaling in liver and prefrontal cortex of CUMS rats with glucose intolerance. Biomed Pharmacother. 2018;103:1415-1428 pubmed publisher
    ..including toll-like receptor 4 (TLR4), myeloid differentiation protein 88 (MyD88), nuclear factor-kappa B (NF-?B), Nod-like receptor family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing CARD (..
  8. Fu J, Sun H, Zhang Y, Xu W, Wang C, Fang Y, et al. Neuroprotective Effects of Luteolin Against Spinal Cord Ischemia-Reperfusion Injury by Attenuation of Oxidative Stress, Inflammation, and Apoptosis. J Med Food. 2017;: pubmed publisher
    ..Western blot analysis was used to examine the expression of nuclear factor erythroid 2-related factor (Nrf2) and nod-like receptor pyrin domain-containing 3 protein (NLRP3) levels...
  9. Boska M, Dash P, Knibbe J, Epstein A, Akhter S, Fields N, et al. Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice. Mol Neurodegener. 2014;9:58 pubmed publisher
    ..Chronic HIV-1 infection of NOD/scid-IL-2Rgcnull mice transplanted with human CD34+ hematopoietic stem cells (CD34-NSG) leads to persistent viremia,..
  10. Kim J, Choi S, Kim Y, Jeong H, Ryu J, Lee H, et al. Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye. Nutrients. 2017;9: pubmed publisher
    ..For an autoimmune dry eye model, 12-weeks-old NOD.B10.H2b mice were used. Donor cornea of B6 mice was transplanted into BALB/C mice...
  11. Chow E, Quach H, Zhang Y, Wang J, Evans D, Li A, et al. Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models. J Pharmacol Exp Ther. 2017;360:174-191 pubmed
    ..gene 2 (Rag2-/-), and interleukin 2 receptor subunit gamma (IL-2rg -/-) triple knockout] on nonobese diabetic (NOD) background] and chimeric mice: mFRGN and hFRGN (repopulated with mouse or human hepatocytes, respectively)...
  12. Lyu Z, Ji X, Chen G, An B. Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress. Int Immunopharmacol. 2019;72:348-357 pubmed publisher
    ..toll like receptor 4 (TLR4), nuclear factor kappa B (NF-κB), the mitogen-activated protein kinase (MAPK) and NOD-like receptor protein-3 (NLRP3) activation pathway...
  13. Ebbing E, Steins A, Fessler E, Stathi P, Lesterhuis W, Krishnadath K, et al. Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition. Gastroenterology. 2017;153:63-76.e14 pubmed publisher
    ..b>NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice were given subcutaneous injections of AMC-EAC-007B ..
  14. Hu J, Zhu Y, Zhang J, Zhang R, Li H. A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome. Chin Med J (Engl). 2017;130:586-593 pubmed publisher
    ..CAPS is associated with gain-of-function missense mutations in NOD-like receptor family pyrin domain-containing protein 3 (NLRP3), the gene encoding NLRP3...
  15. Martínez Torres A, Quiney C, Attout T, Boullet H, Herbi L, Vela L, et al. CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans. PLoS Med. 2015;12:e1001796 pubmed publisher
    ..Additionally, in a CLL-xenograft model developed in NOD/scid gamma mice, we demonstrate that the injection of CD47 agonist peptides reduces tumor burden without inducing ..
  16. Shah M, Brownlee M. Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. Circ Res. 2016;118:1808-29 pubmed publisher
    ..transcription of the neutrophil enzyme initiating NETosis, peptidylarginine deiminase 4, and activates the NOD-like receptor family, pyrin domain-containing 3 inflammasome...
  17. Bettini S, Franceschini V, Astolfi L, Simoni E, Mazzanti B, Martini A, et al. Human mesenchymal stromal cell therapy for damaged cochlea repair in nod-scid mice deafened with kanamycin. Cytotherapy. 2018;20:189-203 pubmed publisher
    ..selected for their availability, in vitro multipotency and regenerative potential in vivo in kanamycin-deafened nod-scid mice. MSCs were isolated from informed donors and expanded ex vivo...
  18. Sharma A, Wu W, Sung B, Huang J, Tsao T, Li X, et al. Respiratory Syncytial Virus (RSV) Pulmonary Infection in Humanized Mice Induces Human Anti-RSV Immune Responses and Pathology. J Virol. 2016;90:5068-5074 pubmed publisher
    ..of HLA class II genes, various human cytokines, and human B cell activation factor into immunodeficient NOD scid gamma (NSG) mice by the use of an adeno-associated virus vector, followed by engraftment of human ..
  19. Yuksel M, Xiao X, Tai N, Vijay M, Gülden E, Beland K, et al. The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model. Clin Exp Immunol. 2016;186:164-176 pubmed publisher
    ..the role of HLA-DR4 in the development of AIH by immunization of HLA-DR4 (DR4) transgenic non-obese diabetic (NOD) mice with DNA coding for human CYP2D6/FTCD fusion autoantigen...
  20. Engin A. The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation. Adv Exp Med Biol. 2017;960:221-245 pubmed publisher
    ..Additionally, systemic oxidative stress, macrophage recruitment, increase in the expression of NOD-like receptor (NLR) family protein (NLRP3) inflammasone and adipocyte death are predominant determinants in the ..
  21. Santagostino S, Arbona R, Nashat M, White J, Monette S. Pathology of Aging in NOD scid gamma Female Mice. Vet Pathol. 2017;54:855-869 pubmed publisher
    In the past decade, NOD.Cg- Prkdcscid Il2rgtm1Wjl/SzJ (NSG, NOD scid gamma) mice have become a model of choice in several areas of biomedical research; however, comprehensive data on their spontaneous age-related ..
  22. Chiu S, Chiu T, Huang S, Chang S, Chen S, Pang C, et al. Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells. BMC Complement Altern Med. 2017;17:523 pubmed publisher
    ..Tumor model in NOD-SCID mice were induced by injection of BFTC human bladder cancer cells...
  23. Wu X, Tang B, Liao X, Su Z, Lee S, Cai Y, et al. Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice. Food Funct. 2019;10:1212-1224 pubmed publisher
    ..investigations demonstrated that SEC inhibited CUMS-induced activation of the nuclear factor kappa B (NF-κB) and NOD-like receptor protein 3 (NLRP3) inflammasomes pathways but upregulated brain-derived neurotrophic factor (BDNF) ..
  24. Xu Y, Yang C, Zhang S, Li J, Xiao Q, Huang W. Ginsenoside Rg1 Protects against Non-alcoholic Fatty Liver Disease by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammasome Activation. Biol Pharm Bull. 2018;41:1638-1644 pubmed publisher
    ..Rg1 alleviated liver inflammation by inhibiting the activation of nucleotide binding oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) and thus reduced the production of inflammatory cytokines, ..
  25. Lindquist M, Zeng X, Altamura L, Daye S, Delp K, Blancett C, et al. Exploring Crimean-Congo Hemorrhagic Fever Virus-Induced Hepatic Injury Using Antibody-Mediated Type I Interferon Blockade in Mice. J Virol. 2018;92: pubmed publisher
    ..Similar experiments in CCHFV-exposed NOD-SCID-γ (NSG), Rag2-deficient, and perforin-deficient mice also demonstrated liver injury, suggesting that ..
  26. Dhanasekar C, Rasool M. Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators. Eur J Pharmacol. 2016;786:116-127 pubmed publisher
    ..The mRNA expression of NLRP3 (nucleotide oligomerization domain (NOD)-like receptor family, pyrin domain containing 3) inflammasome, caspase-1, pro-inflammatory cytokines, MCP-1, ..
  27. Chaves de Souza J, Frasnelli S, Curylofo Zotti F, Avila Campos M, Spolidorio L, Zamboni D, et al. NOD1 in the modulation of host-microbe interactions and inflammatory bone resorption in the periodontal disease model. Immunology. 2016;149:374-385 pubmed publisher
    ..Nucleotide-binding oligomerization domain containing 1 (NOD1) is a member of the Nod-like receptors (NLRs) family of proteins that participate in the activation of the innate immune system, in ..
  28. Xue A, Julovi S, Hugh T, Samra J, Wong M, Gill A, et al. A patient-derived subrenal capsule xenograft model can predict response to adjuvant therapy for cancers in the head of the pancreas. Pancreatology. 2015;15:397-404 pubmed publisher
    ..SRCPCXs from 32 pancreatectomy patients were established in six to ten NOD/SCID mice per patient...
  29. Wang H, Yang M, Lin L, Ren H, Lin C, Lin S, et al. HepG2 cells acquire stem cell-like characteristics after immune cell stimulation. Cell Oncol (Dordr). 2016;39:35-45 pubmed publisher
    ..We also found that 1x10(3) MSBC-HepG2 and MPMC-HepG2 cells were able to form tumors in NOD/SCID mice and that the Notch and SHH signaling pathways were highly activated in MSBC-HepG2 cells...
  30. Furrer A, Hottiger M, Valaperti A. Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation. Mol Immunol. 2016;74:47-58 pubmed publisher
    ..We found that the presence of AIM2, but not of the other inflammasome components Nod-like receptor (NLR) NLRP3 or NLRC4, specifically limited the transcription of the pro-inflammatory cytokines ..
  31. Vazquez Mateo C, Collins J, Fleury M, Dooms H. Broad induction of immunoregulatory mechanisms after a short course of anti-IL-7R? antibodies in NOD mice. BMC Immunol. 2017;18:18 pubmed publisher
    ..Anti-IL-7R? antibodies were administered to prediabetic NOD mice for 3 weeks and blood samples were taken at the end of treatment and 2 weeks later to analyze changes in T ..
  32. Wang Z, Lin L, Thomas D, Nadal E, Chang A, Beer D, et al. The role of Dickkopf-3 overexpression in esophageal adenocarcinoma. J Thorac Cardiovasc Surg. 2015;150:377-385.e2 pubmed publisher
    ..Tumorigenesis was evaluated by injecting 1 × 10(6) OE33/DKK3 and vector cells in NOD/SCIDγ mice. DKK3 was overexpressed (>2-fold) in 75.8% (72/95) of esophageal adenocarcinomas...
  33. Dirice E, Walpita D, Vetere A, Meier B, Kahraman S, Hu J, et al. Inhibition of DYRK1A Stimulates Human β-Cell Proliferation. Diabetes. 2016;65:1660-71 pubmed publisher
    ..Furthermore, 5-IT promotes β-cell proliferation in human islets grafted under the kidney capsule of NOD-scid IL2Rg(null) mice...
  34. Hosokawa Y, Hirao K, Yumoto H, Washio A, Nakanishi T, Takegawa D, et al. Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity. Biomed Res Int. 2016;2016:9325436 pubmed
    ..by pattern recognition receptors, such as Toll-like receptor and nucleotide-binding oligomerization domain (NOD); however, little is known about NODs in odontoblasts...
  35. Wei Z, Wang Y, Yu X, Zhang S. [Identification and characterization of stem cells in an ovarian cancer cell line and examination their drug resistance]. Zhonghua Fu Chan Ke Za Zhi. 2015;50:452-7 pubmed
    ..cell tumorigenesis was examined by subcutaneous and intraperitoneal injection of these cells to nonobes ediabetic (NOD)-severe combined immundeficient (SCID) mice...
  36. Zohaib A, Sarfraz A, Kaleem Q, Ye J, Mughal M, Navid M, et al. The Yin and Yang of Antiviral Innate Immunity in Central Nervous System. Curr Pharm Des. 2016;22:648-55 pubmed
    ..pattern recognition receptors (PRRs) such as Toll like receptors (TLRs), nucleotide binding oligomerization domain (NOD) - like receptors (NLRs), retinoic acid-inducible gene I (RIG-I) -like helicases or RIG-I-like receptors (RLRs) and ..
  37. Stein K, Brand S, Jenckel A, Sigmund A, Chen Z, Kirschning C, et al. Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects. J Allergy Clin Immunol. 2017;139:667-678.e5 pubmed publisher
    ..RNA, and synergistically enhanced by activation of nucleotide-binding oligomerization domain-containing protein (NOD) 2...
  38. Nishiguchi T, Ito I, Lee J, Suzuki S, Suzuki F, Kobayashi M. Macrophage polarization and MRSA infection in burned mice. Immunol Cell Biol. 2017;95:198-206 pubmed publisher
    ..Comparing NOD scid gamma mice inoculated with M? with 25% TBSA burns, all mice treated with CCL1 antisense oligodeoxynucleotide (..
  39. Zgadzaj R, Garrido Oter R, Jensen D, Koprivova A, Schulze Lefert P, Radutoiu S. Root nodule symbiosis in Lotus japonicus drives the establishment of distinctive rhizosphere, root, and nodule bacterial communities. Proc Natl Acad Sci U S A. 2016;113:E7996-E8005 pubmed
    ..Comparative analyses of wild-type (WT) and symbiotic mutants in Nod factor receptor5 (nfr5), Nodule inception (nin) and Lotus histidine kinase1 (lhk1) genes identified a previously ..
  40. He K, Zhu X, Liu Y, Miao C, Wang T, Li P, et al. Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development. Oncotarget. 2017;8:37657-37672 pubmed publisher
    b>NOD-like receptor (NLR) NLRP3 inflammasome activation has been implicated in the progression of non-alcoholic fatty liver disease (NAFLD) from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH)...
  41. Khalafalla M, Woods L, Camden J, Khan A, Limesand K, Petris M, et al. P2X7 receptor antagonism prevents IL-1? release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. J Biol Chem. 2017;292:16626-16637 pubmed publisher
    ..i>in vivo administration of the P2X7R antagonist A438079 in the CD28-/-, IFN?-/-, NOD.H-2h4 mouse model of salivary gland exocrinopathy ameliorated salivary gland inflammation and enhanced ..
  42. McLachlan S, Aliesky H, Banuelos B, Hee S, Rapoport B. Variable Effects of Dietary Selenium in Mice That Spontaneously Develop a Spectrum of Thyroid Autoantibodies. Endocrinology. 2017;158:3754-3764 pubmed publisher
    ..Nonobese diabetic (NOD).H2h4 mice spontaneously develop autoantibodies to thyroglobulin (Tg) and thyroid peroxidase (TPO)...
  43. Sato Y, Nagata S, Takiguchi M. Effective elicitation of human effector CD8+ T Cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1. PLoS ONE. 2012;7:e42776 pubmed publisher
    ..established HLA-B*51:01 transgenic humanized mice by transplanting human CD34(+) HSCs into HLA-B*51:01 transgenic NOD/SCID/Jak3(-/-) mice (hNOK/B51Tg mice) and investigated whether human effector CD8(+) T cells would be elicited in ..
  44. Lee S, Kang W, Yoon Y, Jin J, Song H, Her J, et al. Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain. BMC Cancer. 2015;15:1011 pubmed publisher
    ..from surgical samples of GBM patients and were inoculated into the brains of immune deficient BALB/c-nude or NOD-SCID IL2Rgamma(null) (NSG) mice...
  45. Chen S, Liu Y, Wang X, Wang H, Li S, Shi H, et al. Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge. Innate Immun. 2016;22:577-587 pubmed publisher
  46. Wang L, Ma J, Guo C, Chen C, Yin Z, Zhang X, et al. Danggui Buxue Tang Attenuates Tubulointerstitial Fibrosis via Suppressing NLRP3 Inflammasome in a Rat Model of Unilateral Ureteral Obstruction. Biomed Res Int. 2016;2016:9368483 pubmed
    ..This study aimed to characterize Danggui Buxue Tang (DBT) renoprotection and relationship with NOD-like receptors family pyrin domain-containing 3 (NLRP3) inflammasome expression in rats with unilateral ureteral ..
  47. Xu X, Bian L, Shen M, Li X, Zhu J, Chen S, et al. Multipeptide-coupled nanoparticles induce tolerance in 'humanised' HLA-transgenic mice and inhibit diabetogenic CD8+ T cell responses in type 1 diabetes. Diabetologia. 2017;60:2418-2431 pubmed publisher
    Induction of antigen-specific immunological tolerance may provide an attractive immunotherapy in the NOD mouse model but the conditions that lead to the successful translation to human type 1 diabetes are limited...
  48. Szpigel A, Hainault I, Carlier A, Venteclef N, Batto A, Hajduch E, et al. Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes. Diabetologia. 2018;61:399-412 pubmed publisher
    ..Recently, the thioredoxin interacting protein (TXNIP) has been implicated in the activation process of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome...
  49. Wang L, Ouyang F, Liu X, Wu S, Wu H, Xu Y, et al. Overexpressed CISD2 has prognostic value in human gastric cancer and promotes gastric cancer cell proliferation and tumorigenesis via AKT signaling pathway. Oncotarget. 2016;7:3791-805 pubmed publisher
    ..inhibited the proliferation and tumorigenicity of MGC-803 and SGC-7901 cells not only in vitro but also in vivo in NOD/SCID mice (P < 0.05)...
  50. Xiang J, Zhang S, Leclercq G, Nauwynck H. Difference in replication of low-passage MCMV HaNa1 in BALB/c, C57BL/6 and NOD mice and role of different branches of immunity in susceptibility. Virus Res. 2016;221:38-46 pubmed publisher
    ..Here, different inbred mice (BALB/c, C57BL/6 and NOD) were inoculated oronasally with a low-passage MCMV strain, HaNa1...
  51. Richard E, Grellety T, Velasco V, MacGrogan G, Bonnefoi H, Iggo R. The mammary ducts create a favourable microenvironment for xenografting of luminal and molecular apocrine breast tumours. J Pathol. 2016;240:256-261 pubmed publisher
    ..overnight with a lentiviral vector expressing tdTomato and injected through the nipple into the mammary ducts of NOD-SCID-IL2RG-/- mice...
  52. Sandén E, Dyberg C, Krona C, Gallo Oller G, Olsen T, Enríquez Pérez J, et al. Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation. Sci Rep. 2017;7:46366 pubmed publisher
    ..we acquired a patient-derived tumour sphere culture and inoculated low-passage spheres into the cerebellums of NOD-scid mice. Mice developed symptoms of brain tumours with a latency of 17-18 weeks...
  53. Zhang W, Liu Y, Wu M, Zhu X, Wang T, He K, et al. PI3K inhibition protects mice from NAFLD by down-regulating CMKLR1 and NLRP3 in Kupffer cells. J Physiol Biochem. 2017;73:583-594 pubmed publisher
    ..Consistently, the expression of chemokine-like receptor 1 (CMKLR1) and nucleotide oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) was significantly lower in the KCs and mice treated with ..
  54. Tonkin R, Bowles C, Perera C, Keating B, Makker P, Duffy S, et al. Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Exp Neurol. 2018;300:1-12 pubmed publisher
    ..Since ATP is a known activator of the NOD-like receptor protein 3 (NLRP3) inflammasome complex, a key mediator of neuroinflammation, we examined the effects ..
  55. Shafa M, Ionescu L, Vadivel A, Collins J, Xu L, Zhong S, et al. Human induced pluripotent stem cell-derived lung progenitor and alveolar epithelial cells attenuate hyperoxia-induced lung injury. Cytotherapy. 2018;20:108-125 pubmed publisher
    ..therapy, undifferentiated hiPSCs also preserved lung function and alveolar growth in hyperoxia-exposed neonatal NOD/SCID mice...
  56. Lakhter A, Pratt R, Moore R, Doucette K, Maier B, DiMeglio L, et al. Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes. Diabetologia. 2018;61:1124-1134 pubmed publisher
    ..Serum was collected weekly from 8-week-old female NOD mice until diabetes onset...
  57. Pearson J, Wong F, Wen L. The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes. J Autoimmun. 2016;66:76-88 pubmed publisher
    ..The successes of the Non-Obese Diabetic (NOD) mouse model have come in multiple forms including identifying key genetic and environmental risk factors e.g...
  58. Zhang L, Cong X, Zhang Y, Wei T, Su Y, Serrão A, et al. Interleukin-17 Impairs Salivary Tight Junction Integrity in Sjögren's Syndrome. J Dent Res. 2016;95:784-92 pubmed publisher
    ..Here, by using nonobese diabetic (NOD) mice as SS model, we found that the stimulated salivary flow rate was significantly decreased in NOD mice...
  59. Wu X, Hu Y, Xue N, Ren S, Chen S, Nie P, et al. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Dev Comp Immunol. 2017;68:58-68 pubmed publisher
    Intracellular NOD-like receptors (NLRs) are emerging as critical regulators of innate and adaptive immune responses...
  60. Arainga M, Edagwa B, Mosley R, Poluektova L, Gorantla S, Gendelman H. A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy. Retrovirology. 2017;14:17 pubmed publisher
    ..To such ends, we used HIV-1ADA-infected NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ mice reconstituted with a human immune system to explore two ..
  61. Oharomari L, de Moraes C, Navarro A. Exercise Training but not Curcumin Supplementation Decreases Immune Cell Infiltration in the Pancreatic Islets of a Genetically Susceptible Model of Type 1 Diabetes. Sports Med Open. 2017;3:15 pubmed publisher
    ..The non-obese diabetic (NOD) mouse is a model of spontaneous T1D and is the model most similar to human disease...
  62. Sharma A, Vatapalli R, Abdelfatah E, Wyatt McMahon K, Kerner Z, A Guzzetta A, et al. Hypomethylating agents synergize with irinotecan to improve response to chemotherapy in colorectal cancer cells. PLoS ONE. 2017;12:e0176139 pubmed publisher
    ..agent, 5-aza-cytidine (AZA) in-vitro, and the cells then established as in-vivo xenografts in untreated NOD-SCID mice; there is an enhanced response to cytotoxic chemotherapy with agents commonly used in CRC treatment...
  63. Miraglia M, Costa Franco M, Rodriguez A, Bellozi P, Ferrari C, Farias M, et al. Glial Cell-Elicited Activation of Brain Microvasculature in Response to Brucella abortus Infection Requires ASC Inflammasome-Dependent IL-1? Production. J Immunol. 2016;196:3794-805 pubmed publisher
    ..Both absent in melanoma 2 and Nod-like receptor containing a pyrin domain 3 are partially required for caspase-1 activation and IL-1? secretion, ..
  64. Bernales C, Encarnacion M, Criscuoli M, Yee I, Traboulsee A, Sadovnick A, et al. Analysis of NOD-like receptor NLRP1 in multiple sclerosis families. Immunogenetics. 2018;70:205-207 pubmed publisher
    ..G587S mutation. Further studies are necessary to confirm a role of NLRP1 in the pathophysiology of MS. ..
  65. Bonami R, Thomas J. Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice. J Immunol. 2015;195:4730-41 pubmed publisher
    ..The proportion of anti-insulin B cells that underwent receptor editing was reduced in the type 1 diabetes-prone NOD strain relative to a nonautoimmune strain...
  66. Wiernicki B, Rozwadowska N, Malcher A, Kolanowski T, Zimna A, Rugowska A, et al. Human myoblast transplantation in mice infarcted heart alters the expression profile of cardiac genes associated with left ventricle remodeling. Int J Cardiol. 2016;202:710-21 pubmed publisher
    ..Using NOD-SCID murine model of MI and human skeletal myoblast transplantation we were able to show that SkMC administration ..
  67. Wu L, Li N, Zhang M, Xue S, Cassady K, Lin Q, et al. MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice. Proc Natl Acad Sci U S A. 2015;112:15994-9 pubmed publisher
    ..We have reported that induction of MHC-mismatched mixed chimerism can cure autoimmunity in autoimmune NOD mice, but this approach has not yet been tested in animal models of MS, such as experimental autoimmune ..
  68. Puyang Z, Feng L, Chen H, Liang P, Troy J, Liu X. Retinal Ganglion Cell Loss is Delayed Following Optic Nerve Crush in NLRP3 Knockout Mice. Sci Rep. 2016;6:20998 pubmed publisher
    ..Speck-like protein containing a Caspase Activation and Recruitment Domain (CARD)), pro-caspase-1, and NLRP3 (NOD-Like Receptor family Pyrin domain containing 3)...
  69. Kovarova M, Swanson M, Sanchez R, Baker C, Steve J, Spagnuolo R, et al. A long-acting formulation of the integrase inhibitor raltegravir protects humanized BLT mice from repeated high-dose vaginal HIV challenges. J Antimicrob Chemother. 2016;71:1586-96 pubmed publisher
    ..Here, we evaluated a new long-acting formulation of raltegravir for prevention of vaginal HIV transmission...
  70. Lehmann C, Friess T, Birzele F, Kiialainen A, Dangl M. Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia models. J Hematol Oncol. 2016;9:50 pubmed publisher
    ..and orthotopic xenograft models generated in female nude or non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice...
  71. Dupont L, Garcia I, Poggi M, Alloing G, Mandon K, Le Rudulier D. The Sinorhizobium meliloti ABC transporter Cho is highly specific for choline and expressed in bacteroids from Medicago sativa nodules. J Bacteriol. 2004;186:5988-96 pubmed
    ..The choX mutation did not have an effect on growth under standard conditions, and neither Nod nor Fix phenotypes were impaired in the mutant, suggesting that the remaining choline uptake system(s) still ..
  72. Tonsing Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed publisher
    ..In vivo efficacy studies were conducted in the TMD231 orthotopic mammary fat pad model in NOD.Cg-Prkdc(scid)Il2rg(tm1Wjl)/SzJ (NSG) mice...
  73. Randhawa S, Cho B, Ghosh D, Sivina M, Koehrer S, Müschen M, et al. Effects of pharmacological and genetic disruption of CXCR4 chemokine receptor function in B-cell acute lymphoblastic leukaemia. Br J Haematol. 2016;174:425-36 pubmed publisher
    ..b>NOD/SCID/IL-2rγnull mice injected with CXCR4 gene-deleted B-ALL cells had significant delay in disease progression ..
  74. William D, Mullins C, Schneider B, Orthmann A, Lamp N, Krohn M, et al. Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies. J Transl Med. 2017;15:27 pubmed publisher
    ..Engraftment success was compared between NMRI Foxn1nu and NOD/SCID as well as between fresh and cryopreserved tissue...
  75. Alvarez C, Ramírez Cepeda F, Santana P, Torres E, Cortes J, Guzman F, et al. Insights into the diversity of NOD-like receptors: Identification and expression analysis of NLRC3, NLRC5 and NLRX1 in rainbow trout. Mol Immunol. 2017;87:102-113 pubmed publisher
    Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are efficient soluble intracellular sensors that activate defense mechanisms against pathogens...
  76. Zou F, Lai X, Li J, Lei S, Hu L. Downregulation of cathepsin G reduces the activation of CD4+ T cells in murine autoimmune diabetes. Am J Transl Res. 2017;9:5127-5137 pubmed
    ..mouse studies were conducted to demonstrate that CatG impacts the activation of CD4+ T cells in non-obese diabetic (NOD) mice. CatG gene expression and the activation of CD4+ T cells were examined in NOD mice...
  77. Suliman N, Taib C, Moklas M, Basir R. Delta-9-Tetrahydrocannabinol (∆9-THC) Induce Neurogenesis and Improve Cognitive Performances of Male Sprague Dawley Rats. Neurotox Res. 2018;33:402-411 pubmed publisher
    ..The cognitive test was used novel-object discrimination test (NOD) while the proteins involved, DCX and brain-derived neurotrophic factor (BDNF), were measured...
  78. de Oliveira E, Lazovic J, Guo L, Soto H, Faintuch B, Akhtari M, et al. Evaluation of Magnetonanoparticles Conjugated with New Angiogenesis Peptides in Intracranial Glioma Tumors by MRI. Appl Biochem Biotechnol. 2017;183:265-279 pubmed publisher
    ..MR imaging was performed in U87 glioblastoma-bearing NOD-SCID mice at different time points between 15 and 120 min post-injection to visualize particle distribution...
  79. Guo L, Kong Q, Dong Z, Dong W, Fu X, Su L, et al. NLRC3 promotes host resistance against Pseudomonas aeruginosa-induced keratitis by promoting the degradation of IRAK1. Int J Mol Med. 2017;40:898-906 pubmed publisher
    ..Nucleotide oligomerization domain (NOD)-like receptor (NLR) family with caspase activation and recruitment domain (CARD) containing 3 (NLRC3) ..
  80. Luo X, Yu Z, Deng C, Zhang J, Ren G, Sun A, et al. Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice. Sci Rep. 2017;7:16374 pubmed publisher
    ..Furthermore, baicalein reduced NOD-like receptor 3 (NLRP3) inflammasome activation and downstream interleukin-1β expression in a dose-dependent ..
  81. Santos D, Campos T, Saldanha M, Oliveira S, Nascimento M, Zamboni D, et al. IL-1β Production by Intermediate Monocytes Is Associated with Immunopathology in Cutaneous Leishmaniasis. J Invest Dermatol. 2018;138:1107-1115 pubmed publisher
    ..These results identify an important role for human intermediate monocytes in the production of IL-1β, which contributes to the immunopathology observed in cutaneous leishmaniasis patients. ..
  82. Tsuji S. Dentatorubral-pallidoluysian atrophy. Handb Clin Neurol. 2012;103:587-94 pubmed publisher
    Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare autosomal dominant neurodegenerative disorder clinically characterized by various combinations of cerebellar ataxia, choreoathetosis, myoclonus, epilepsy, dementia, and psychiatric ..
  83. Pitanga T, Oliveira R, Zanette D, Guarda C, Santiago R, Santana S, et al. Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell. Cytokine. 2016;83:75-84 pubmed publisher
    This study tested the hypothesis that sickle red blood cell (SS-RBC) induce Toll-like receptors (TLR) and Nod-like receptor family, pyrin domain containing 3 (NLRP3)- inflammasome expression in peripheral blood mononuclear cells (PBMC)...
  84. Martinic M, Caminschi I, O Keeffe M, Thinnes T, Grumont R, Gerondakis S, et al. The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+ Thymocyte Selection. J Immunol. 2017;198:2649-2660 pubmed publisher
    Nucleotide-binding and oligomerization domain (NOD)-like receptors NOD1 and NOD2 are cytosolic innate immune receptors that recognize microbial peptidoglycans...
  85. Murfitt S, Zaccone P, Wang X, Acharjee A, Sawyer Y, Koulman A, et al. A metabolomics and lipidomics study of mouse models of type 1 diabetes highlights divergent metabolism in purine and tryptophan metabolism prior to disease on-set. J Proteome Res. 2017;: pubmed publisher
    ..to follow the progression of disease in three models related to autoimmune diabetes: the non-obese diabetic (NOD) mouse, which is susceptible to the development of autoimmune diabetes, and the NOD-E (transgenic NOD mice that ..
  86. Sarvestani S, McAuley J. The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infection. Antiviral Res. 2017;148:32-42 pubmed publisher
    ..multiprotein oligomers which includes a sensor protein such as the nucleotide-binding oligomerization domain (NOD) like receptor proteins (NLRP), and an adapter protein, ASC, which critically activates pro-caspase-1...
  87. Ranson N, Kunde D, Eri R. Regulation and Sensing of Inflammasomes and Their Impact on Intestinal Health. Int J Mol Sci. 2017;18: pubmed publisher
    Pattern recognition receptors such as nucleotide-binding oligomerization domain (NOD)-containing protein receptors (NLRs) and the pyrin and hematopoitic interferon-inducible nuclear protein (HIN) domain (PYHIN) receptors initiate the ..
  88. Bacopulos S, Amemiya Y, Yang W, Zubovits J, Burger A, Yaffe M, et al. Effects of partner proteins on BCA2 RING ligase activity. BMC Cancer. 2012;12:63 pubmed publisher
    ..The interaction between BCA2 and hHR23a in breast cancer cells stabilizes BCA2. High expression of BCA2 is correlated with grade in breast cancer, suggesting regulation of this E3 ligase is important to cancer progression. ..
  89. Zhu B, Bradford L, Huang S, Szalay A, Leix C, Weissbach M, et al. Unexpected Diversity and High Abundance of Putative Nitric Oxide Dismutase (Nod) Genes in Contaminated Aquifers and Wastewater Treatment Systems. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..It may represent a new pathway in microbial nitrogen cycling catalyzed by a putative NO dismutase (Nod)...
  90. Liu H, Xu R, Kong Q, Liu J, Yu Z, Zhao C. Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitus. Biomed Pharmacother. 2017;94:619-626 pubmed publisher
    ..with siRNA, or ovexpressed by infected with lentiviral vectors in PBMCs and GCs from non obese diabetic (NOD) mice, respectively...
  91. MacDonagh L, Gallagher M, Ffrench B, Gasch C, Breen E, Gray S, et al. Targeting the cancer stem cell marker, aldehyde dehydrogenase 1, to circumvent cisplatin resistance in NSCLC. Oncotarget. 2017;8:72544-72563 pubmed publisher
    ..Xenograft studies in NOD/SCID mice demonstrated efficient tumorigenesis from low cell numbers of ALDH1-positive and ALDH1-negative ..
  92. Yu J, Zhu Y, Yang G, Zhang W, Zhou D, Su J, et al. Anti-inflammatory capacity of Lactobacillus rhamnosus GG in monophasic variant Salmonella infected piglets is correlated with impeding NLRP6-mediated host inflammatory responses. Vet Microbiol. 2017;210:91-100 pubmed publisher
    ..LGG also impeded the activation of the Nod-like receptor protein (NLRP) 6/apoptosis-associated speck-like protein/caspase-1 inflammasome and decreased the ..