Gene Symbol: DRD5
Description: dopamine receptor D5
Alias: DBDR, DRD1B, DRD1L2, D(1B) dopamine receptor, D1beta dopamine receptor, d(5) dopamine receptor, dopamine D5 receptor, dopamine receptor D1B
Species: human
Products:     DRD5

Top Publications

  1. Shepherd A, Lea R, Hutchins C, Jordan K, Brimage P, Griffiths L. Dopamine receptor genes and migraine with and without aura: an association study. Headache. 2002;42:346-51 pubmed
    To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine. Migraine is a chronic debilitating disorder affecting approximately 12% of the white population...
  2. Zheng S, Yu P, Zeng C, Wang Z, Yang Z, Andrews P, et al. Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron. Hypertension. 2003;41:604-10 pubmed
    ..The consequences of the differential G-protein subunit linkage on D1- and D5-mediated sodium transport remains to be determined. ..
  3. Sidhu A, Kimura K, Uh M, White B, Patel S. Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz. J Neurochem. 1998;70:2459-67 pubmed
    ..2 +/- 5.2% of G protein-associated D5 receptors, indicating coupling between D5 and Gz alpha. The coupling to Gz alpha was specific for D5 receptors, because similar associations were not detected between D1 receptors and Gz alpha. ..
  4. Stochino M, Asuni C, Congiu D, Del Zompo M, Severino G. Association study between the phenotype migraine without aura-panic disorder and dopaminergic receptor genes. Pharmacol Res. 2003;48:531-4 pubmed
    ..The allele frequencies of DRD1, DRD3, DRD5, DRD2 in probands did not differ from that of parental non-transmitted chromosomes...
  5. Yang Z, Asico L, Yu P, Wang Z, Jones J, Escano C, et al. D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure. Am J Physiol Regul Integr Comp Physiol. 2006;290:R96-R104 pubmed
    ..The ability of D5 receptor stimulation to decrease ROS production may explain, in part, the antihypertensive action of D5 receptor activation. ..
  6. Gildea J, Wang X, Jose P, Felder R. Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor. Hypertension. 2008;51:360-6 pubmed publisher
    ..The discovery of differential regulation by D(1)R and D(5)R opens new avenues for the development of agonists selective to either receptor subtype as targeted antihypertensive agents that can decrease AT(1)R-mediated antinatriuresis. ..
  7. Gildea J, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, et al. Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. Hypertension. 2012;60:396-403 pubmed publisher
    ..These studies shed new light on the regulation of renal sodium transport by the dopaminergic and angiotensin systems and potential new therapeutic targets for selectively treating hypertension. ..
  8. Sunahara R, Guan H, O Dowd B, Seeman P, Laurier L, Ng G, et al. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991;350:614-9 pubmed
    ..As with D1, the dopamine D5 receptor stimulates adenylyl cyclase activity...
  9. Hawi Z, Cummins T, Tong J, Johnson B, Lau R, Samarrai W, et al. The molecular genetic architecture of attention deficit hyperactivity disorder. Mol Psychiatry. 2015;20:289-97 pubmed publisher
    ..Candidate gene associations of minor effect size have been replicated across a number of genes including SLC6A3, DRD5, DRD4, SLC6A4, LPHN3, SNAP-25, HTR1B, NOS1 and GIT1...

More Information

Publications116 found, 100 shown here

  1. Prabhu V, Madhukar N, Gilvary C, Kline C, Oster S, El Deiry W, et al. Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism. Clin Cancer Res. 2019;25:2305-2313 pubmed publisher
    ..b>DRD5 is a dopamine receptor family member that opposes DRD2 signaling...
  2. Hallgren S, Viberg H. Postnatal exposure to PFOS, but not PBDE 99, disturb dopaminergic gene transcription in the mouse CNS. Environ Toxicol Pharmacol. 2016;41:121-6 pubmed publisher
    ..tissue from mice euthanized 24h post exposure revealed that PFOS affected transcription of Dopamine receptor-D5 (DRD5) in cerebral cortex and Tyrosine hydroxylase (TH) in the hippocampus...
  3. Khan Z, Gutierrez A, Martin R, Penafiel A, Rivera A, De la Calle A. Dopamine D5 receptors of rat and human brain. Neuroscience. 2000;100:689-99 pubmed
    ..Furthermore, the presence of D5 receptors in the areas of dopamine pathways suggests that this receptor may participate actively in dopaminergic neurotransmission. ..
  4. Gahete M, Rubio A, Duran Prado M, Avila J, Luque R, Castaño J. Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients. J Alzheimers Dis. 2010;20:465-75 pubmed publisher
    ..Collectively, our results define a comprehensive scenario wherein reduction of ssts, drds, and sst ligands SST and CST, could be involved, at least in part, in some of the more important defects observed in AD. ..
  5. Missale C, Nash S, Robinson S, Jaber M, Caron M. Dopamine receptors: from structure to function. Physiol Rev. 1998;78:189-225 pubmed
    ..However, targeted deletion of several of these dopamine receptor genes in mice should provide valuable information about their physiological functions...
  6. Leng Z, Lin S, Wu Z, Guo Y, Cai L, Shang H, et al. Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death. Autophagy. 2017;13:1404-1419 pubmed publisher
    ..However, their therapeutic mechanisms are not fully understood. In this study we demonstrated that DRD5 (dopamine receptor D5) agonists were potent inhibitors of pituitary tumor growth...
  7. Brancati F, Valente E, Castori M, Vanacore N, Sessa M, Galardi G, et al. Role of the dopamine D5 receptor (DRD5) as a susceptibility gene for cervical dystonia. J Neurol Neurosurg Psychiatry. 2003;74:665-6 pubmed
    ..Recently, a polymorphism in the dopamine D5 receptor (DRD5) gene has been associated with the disease in a British population, suggesting that DRD5 is a ..
  8. Thompson D, Whistler J. Trafficking properties of the D5 dopamine receptor. Traffic. 2011;12:644-56 pubmed publisher
    ..Together, these data show that the D5 receptor shows a trafficking profile distinct from that of any of the other dopamine receptors. ..
  9. Plouffe B, Yang X, Tiberi M. The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner. Cell Signal. 2012;24:106-18 pubmed publisher
    ..Overall, our results strongly suggest that IL3 is the critical determinant underlying the subtype-specific regulation of human D1-like receptor responsiveness by PKC. ..
  10. Pornour M, Ahangari G, Hejazi S, Ahmadkhaniha H, Akbari M. Dopamine receptor gene (DRD1-DRD5) expression changes as stress factors associated with breast cancer. Asian Pac J Cancer Prev. 2014;15:10339-43 pubmed
    ..from PBMC and MCF-7 cells and RT-PCR was performed to confirm the presence of five dopamine receptors (DRD1-DRD5). Expression changes of dopamine receptor genes were evaluated by real time PCR...
  11. Sadat Shirazi M, Zarrindast M, Daneshparvar H, Ziaie A, Fekri M, Abbasnezhad E, et al. Alteration of dopamine receptors subtypes in the brain of opioid abusers: A postmortem study in Iran. Neurosci Lett. 2018;687:169-176 pubmed publisher
    ..In mRNA and protein level of DRD5, it followed the same pattern like DRD1...
  12. Misbahuddin A, Placzek M, Chaudhuri K, Wood N, Bhatia K, Warner T. A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. Neurology. 2002;58:124-6 pubmed
    ..Allele 2 of a DRD5 dinucleotide repeat was significantly associated with blepharospasm...
  13. Sibbing D, Asmus F, Konig I, Tezenas du Montcel S, Vidailhet M, Sangla S, et al. Candidate gene studies in focal dystonia. Neurology. 2003;61:1097-101 pubmed
    ..in the DYT1 gene can cause focal dystonia, and an association with a polymorphism in the D5 receptor gene (DRD5) has been reported but not confirmed...
  14. Nyman E, Loukola A, Varilo T, Ekelund J, Veijola J, Joukamaa M, et al. Impact of the dopamine receptor gene family on temperament traits in a population-based birth cohort. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:854-65 pubmed publisher
    ..we investigated one gene family in its entirety by addressing the role of all known dopamine receptor genes, DRD1-DRD5, on Cloninger's temperament traits in a Finnish population-based birth cohort...
  15. Molina Fuentes Ã, Pacheco D, Marín P, Philipp B, Schink B, Marqués S. Identification of the Gene Cluster for the Anaerobic Degradation of 3,5-Dihydroxybenzoate (α-Resorcylate) in Thauera aromatica Strain AR-1. Appl Environ Microbiol. 2015;81:7201-14 pubmed publisher
    ..operons, three of which have been shown to be under the control of a single LysR-type transcriptional regulator, DbdR. Despite sequence homology, the genetic organizations of the clusters in T. aromatica strain AR-1 and A...
  16. Andreou D, Söderman E, Axelsson T, Sedvall G, Terenius L, Agartz I, et al. Associations between a locus downstream DRD1 gene and cerebrospinal fluid dopamine metabolite concentrations in psychosis. Neurosci Lett. 2016;619:126-30 pubmed publisher
    ..e., DRD1, DRD2, DRD3, DRD4 and DRD5, and the CSF HVA concentrations in 74 patients with psychotic disorder...
  17. Wohl M, Purper Ouakil D, Mouren M, Ades J, Gorwood P. [Meta-analysis of candidate genes in attention-deficit hyperactivity disorder]. Encephale. 2005;31:437-47 pubmed
    ..13, p = 0.21). On the other hand, DRD4 (OR = 1.26, p = 0.01) and DRD5 (OR = 1.4, p = 0...
  18. Pal P, Mihanovic M, Molnar S, Xi H, Sun G, Guha S, et al. Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population. Croat Med J. 2009;50:361-9 pubmed
    ..frequency differences between schizophrenia cases and controls were observed at 4 tagSNPs located in the genes DRD5, HTR1B1, DBH, and TH1 (P<0.005). A trend test also confirmed the genotypic association (P<0...
  19. D Aoust J, Tiberi M. Role of the extracellular amino terminus and first membrane-spanning helix of dopamine D1 and D5 receptors in shaping ligand selectivity and efficacy. Cell Signal. 2010;22:106-16 pubmed publisher
    ..In summary, our study shows that NT and TM1 of D1-like receptors control ligand binding and agonist-induced activation, poising these regions as important structural determinants for catecholamine GPCR function. ..
  20. O Dowd B, Nguyen T, Ji X, George S. D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation. Biochem Biophys Res Commun. 2013;431:586-9 pubmed publisher
    ..Any pairing of these three D(5) receptor glutamic acids were sufficient for heteromer formation. These identified residues in D(5) and D(2) receptors are oppositely charged and likely interact by electrostatic interactions. ..
  21. Loo S, Rich E, Ishii J, McGough J, McCracken J, Nelson S, et al. Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes. J Child Psychol Psychiatry. 2008;49:950-7 pubmed publisher
    ..Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5)...
  22. Tımırcı Kahraman Ö, Yilmaz U, Yilmaz N, Cevik A, Horozoglu C, Celik F, et al. A Study of Short- and Long-term mRNA Levels of the Retn, Iapp, and Drd5 Genes in Obese Mice Induced with High-fat Diet. In Vivo. 2018;32:813-817 pubmed publisher
    ..this study, we aimed to examine the expression of resistin (Retn), amylin (Iapp), and dopamine receptor domain 5 (Drd5) genes previously suggested to contribute to the pathogenesis of obesity, albeit controversially...
  23. Wang J, Zhao C, Chen B, Liu Z. Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease. Neurosci Lett. 2004;355:193-6 pubmed
    ..Our data suggest that the loci investigated here are not associated with the visual hallucinogenesis in Parkinson's disease. ..
  24. Housley D, Nikolas M, Venta P, Jernigan K, Waldman I, Nigg J, et al. SNP discovery and haplotype analysis in the segmentally duplicated DRD5 coding region. Ann Hum Genet. 2009;73:274-82 pubmed publisher
    The dopamine receptor 5 gene (DRD5) holds much promise as a candidate locus for contributing to neuropsychiatric disorders and other diseases influenced by the dopaminergic system, as well as having potential to affect normal behavioral ..
  25. Zainal Abidin S, Tan E, Chan S, Jaafar A, Lee A, Abd Hamid M, et al. DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson's disease patients. BMC Neurol. 2015;15:59 pubmed publisher
    ..rs265981), DRD2 (ANKK1 rs1800497, rs104894220 and rs144999500), DRD3 (rs3732783 and rs6280), DRD4 (rs1800443), and DRD5 (rs144132215)] and 1 polymorphism in GRIN2B (rs7301328) in PD patients with (cases, n = 52) and without (controls, ..
  26. Muller D, Chiesa A, Mandelli L, De Luca V, De Ronchi D, Jain U, et al. Correlation of a set of gene variants, life events and personality features on adult ADHD severity. J Psychiatr Res. 2010;44:598-604 pubmed publisher
    ..Common polymorphisms within a set of nine important candidate genes (SLC6A3, DBH, DRD4, DRD5, HTR2A, CHRNA7, BDNF, PRKG1 and TAAR9) were genotyped for each subject...
  27. Oporto G, Bornhardt T, Iturriaga V, Salazar L. Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism. Clin Oral Investig. 2018;22:331-337 pubmed publisher
    ..the frequency of single nucleotide polymorphisms (SNPs) in dopaminergic pathway genes (DRD1, DRD2, DRD3, DRD4, DRD5, and MAOB) in patients undergoing bruxism treatment and controls...
  28. Jürgensen S, Antonio L, Mussi G, Brito Moreira J, Bomfim T, De Felice F, et al. Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers. J Biol Chem. 2011;286:3270-6 pubmed publisher
    ..Results suggest that D1/D5 receptors may be relevant targets for development of novel pharmacological approaches to prevent synapse failure in AD. ..
  29. Wei J, Chu C, Wang Y, Yang Y, Wang Q, Li T, et al. Association study of 45 candidate genes in nicotine dependence in Han Chinese. Addict Behav. 2012;37:622-6 pubmed publisher
    ..Individual SNP-based association analysis revealed that nine SNPs located in DRD3 (rs2630351), DRD5 (rs1967550), MAP3K4 (rs2314378), DDC (rs11575461), CHRNB3 (rs4954), GABBR2 (rs2779562), DRD2 (rs11214613 and ..
  30. Kabbani N, Negyessy L, Lin R, Goldman Rakic P, Levenson R. Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. J Neurosci. 2002;22:8476-86 pubmed
    ..NCS-1-D2 receptor interaction may serve to couple dopamine and calcium signaling pathways, thereby providing a critical component in the regulation of dopaminergic signaling in normal and diseased brain. ..
  31. Klein M, Berger S, Hoogman M, Dammers J, Makkinje R, Heister A, et al. Meta-analysis of the DRD5 VNTR in persistent ADHD. Eur Neuropsychopharmacol. 2016;26:1527-1532 pubmed publisher
    ..b>DRD5, the gene encoding the dopamine receptor D5, was recently confirmed as a candidate gene for ADHD in children ..
  32. Hack L, Kalsi G, Aliev F, Kuo P, Prescott C, Patterson D, et al. Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). Alcohol Clin Exp Res. 2011;35:376-85 pubmed publisher
    ..Two SNPs across 2 genes were associated with a disinhibitory symptom count, while 1 SNP in DRD5 was positive for association with the general disinhibitory factor score...
  33. Villar V, Jones J, Armando I, Asico L, Escano C, Lee H, et al. Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice. J Biol Chem. 2013;288:152-63 pubmed publisher
    ..The dopamine D5 receptor (D(5)R) interacts with sorting nexin 1 (SNX1), a protein involved in receptor retrieval from the trans-..
  34. Kool M, Galac S, van der Helm N, Spandauw C, Kooistra H, Mol J. Expression of somatostatin, dopamine, progesterone and growth hormone receptor mRNA in canine cortisol-secreting adrenocortical tumours. Vet J. 2015;206:108-10 pubmed publisher
    ..growth hormone receptor, progesterone receptor, somatostatin receptors (SSTR1-3) and dopamine receptors (DRD1-2 and DRD5) was evaluated in 36 canine ATs and 15 adrenal glands obtained from healthy dogs...
  35. Yu P, Sun M, Villar V, Zhang Y, Weinman E, Felder R, et al. Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells. Cell Signal. 2014;26:2521-9 pubmed publisher
    ..We conclude that LRs are essential not only for the proper membrane distribution and maintenance of AC5/6 activity but also for the regulation of D1R- and D5R-mediated AC signaling. ..
  36. Muller D, Zai C, Sicard M, Remington E, Souza R, Tiwari A, et al. Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain. Pharmacogenomics J. 2012;12:156-64 pubmed publisher
    ..polymorphisms (SNPs) and one variable-number tandem repeat, spanning the five dopamine receptor genes (DRD1-DRD5) were analyzed...
  37. Ruegsegger G, Brown J, Kovarik M, Miller D, Booth F. Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running. Neuroscience. 2016;339:525-537 pubmed publisher
    ..Naltrexone (20mg/kg) decreased tyrosine hydroxylase mRNA in the ventral tegmental area and Fos and Drd5 mRNA in NAc shell of HVR, but not LVR, rats...
  38. Weinshank R, Adham N, Macchi M, Olsen M, Branchek T, Hartig P. Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene. J Biol Chem. 1991;266:22427-35 pubmed
    ..This new receptor appears to be identical to the recently described dopamine D5 receptor. A second closely related gene, GL39, was isolated and shown to represent a pseudogene, the first to be ..
  39. Johansson S, Halleland H, Halmøy A, Jacobsen K, Landaas E, Dramsdahl M, et al. Genetic analyses of dopamine related genes in adult ADHD patients suggest an association with the DRD5-microsatellite repeat, but not with DRD4 or SLC6A3 VNTRs. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1470-5 pubmed
    ..5 kb upstream of the DRD5 locus and the 3'UTR dopamine transporter SLC6A3 (DAT 1) VNTR...
  40. Cosentino M, Ferrari M, Kustrimović N, Rasini E, Marino F. Influence of dopamine receptor gene polymorphisms on circulating T lymphocytes: A pilot study in healthy subjects. Hum Immunol. 2015;76:747-52 pubmed publisher
    ..peripheral blood of healthy subjects and their association with selected DR gene variants (DRD1 rs4532 and rs686, DRD5 rs6283, DRD2 rs1800497 and rs6277, DRD3 rs6280 and rs1800828, DRD4 rs747302 and 7 48-base pair VNTR)...
  41. Fonseca D, Mateus H, Gálvez J, Forero D, Talero Gutierrez C, Velez van Meerbeke A. Lack of association of polymorphisms in six candidate genes in colombian adhd patients. Ann Neurosci. 2015;22:217-21 pubmed publisher
    ..Candidate genes include those related to dopaminergic (e.g. DRD4, DRD5, SLC6A3 and DBH)and serotoninergic (e.g.HTR1B and SLC6A4) pathways...
  42. Maitra S, Sarkar K, Sinha S, Mukhopadhyay K. The Dopamine Receptor D5 May Influence Age of Onset: An Exploratory Study on Indo-Caucasoid ADHD Subjects. J Child Neurol. 2016;31:1250-6 pubmed publisher
    The objective was to investigate contribution of the dopamine receptor 5 (DRD5) gene variants in the symptoms of attention-deficit/hyperactivity disorder (ADHD) probands since brain regions identified to be affected in these group of ..
  43. Eubanks J, Altherr M, Wagner McPherson C, McPherson J, Wasmuth J, Evans G. Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus. Genomics. 1992;12:510-6 pubmed
    ..We mapped the gene encoding the D5 dopamine receptor (DRD5) to human chromosome 4p, an area implicated in HD and the Wolf-Hirschhorn syndrome, using gene-specific ..
  44. Kustanovich V, Ishii J, Crawford L, Yang M, McGough J, McCracken J, et al. Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5. Mol Psychiatry. 2004;9:711-7 pubmed
    ..uptake, transport and receptor binding of dopamine in the etiology of ADHD, including DRD4, DAT1, DRD2, and DRD5. In the present study, we genotyped a large multiplex sample of ADHD affected children and their parents for ..
  45. Corominas R, Ribases M, Camiña M, Cuenca León E, Pardo J, Boronat S, et al. Two-stage case-control association study of dopamine-related genes and migraine. BMC Med Genet. 2009;10:95 pubmed publisher
    ..The present study does not support the involvement of the DRD1, DRD2, DRD3, DRD5, DBH, COMT, SLC6A3 and TH genes in the genetic predisposition to migraine in the Spanish population.
  46. Akbari M, Kashani F, Ahangari G, Pornour M, Hejazi H, Nooshinfar E, et al. The effects of spiritual intervention and changes in dopamine receptor gene expression in breast cancer patients. Breast Cancer. 2016;23:893-900 pubmed
    ..The findings were of great significance in management and treatment of cancer because they revealed the possibility of using alternative treatments (e.g., spiritual interventions) apart from conventional medical treatments. ..
  47. Sifuentes Rincón A, Trejo Tapia A, Randel R, Ambriz Morales P, Parra Bracamonte G. Bovine dopamine receptors DRD1, DRD4, and DRD5: genetic polymorphisms and diversities among ten cattle breeds. Genet Mol Res. 2016;15: pubmed publisher
    ..and/or between different cattle genetic groups of four novel single nucleotide polymorphisms of the bovine DRD1 and DRD5 genes and one reported SNP from the DRD4 gene...
  48. Comi C, Ferrari M, Marino F, Magistrelli L, Cantello R, Riboldazzi G, et al. Polymorphisms of Dopamine Receptor Genes and Risk of L-Dopa-Induced Dyskinesia in Parkinson's Disease. Int J Mol Sci. 2017;18: pubmed publisher
    ..chain reaction for single nucleotide polymorphisms (SNP) in both D1-like (DRD1A48G; DRD1C62T and DRD5T798C) and D2-like DR (DRD2G2137A, DRD2C957T, DRD3G25A, DRD3G712C, DRD4..
  49. Liu F, Wan Q, Pristupa Z, Yu X, Wang Y, Niznik H. Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors. Nature. 2000;403:274-80 pubmed
  50. Marley A, von Zastrow M. DISC1 regulates primary cilia that display specific dopamine receptors. PLoS ONE. 2010;5:e10902 pubmed publisher
    ..Our findings provide new insight to receptor cell biology and suggest a relationship between DISC1 and neural dopamine signaling. ..
  51. Cosentino M, Zaffaroni M, Legnaro M, Bombelli R, Schembri L, Baroncini D, et al. Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis. J Neuroimmunol. 2016;298:82-9 pubmed publisher
    ..Results show the involvement of dopaminergic and adrenergic pathways in CIS as well as in MS pathogenesis, supporting the evaluation of dopaminergic and adrenergic agents in MS. ..
  52. Sobell J, Lind T, Sigurdson D, Zald D, Snitz B, Grove W, et al. The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. Hum Mol Genet. 1995;4:507-14 pubmed
    To determine whether mutations in the D5 dopamine receptor gene (DRD5) are associated with schizophrenia, the gene was examined in 78 unrelated schizophrenic individuals (156 DRD5 alleles)...
  53. Hemby S, Trojanowski J, Ginsberg S. Neuron-specific age-related decreases in dopamine receptor subtype mRNAs. J Comp Neurol. 2003;456:176-83 pubmed
    ..Furthermore, these results support the hypothesis that alterations in dopaminergic function may also be related to behavioral abnormalities, such as psychosis, that occur with aging. ..
  54. Lasky Su J, Biederman J, Laird N, Tsuang M, Doyle A, Smoller J, et al. Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder. Ann Hum Genet. 2007;71:648-59 pubmed
    ..One hundred and forty-three SNPs were genotyped across five candidate genes (DRD5, SLC6A3, HTR1B, SNAP25, DRD4) for ADHD in 229 families with at least one affected offspring...
  55. Squassina A, Lanktree M, De Luca V, Jain U, Krinsky M, Kennedy J, et al. Investigation of the dopamine D5 receptor gene (DRD5) in adult attention deficit hyperactivity disorder. Neurosci Lett. 2008;432:50-3 pubmed publisher
    ..5 kb from the start codon of the DRD5 gene, and ADHD...
  56. Gardner M, Bertranpetit J, Comas D. Worldwide genetic variation in dopamine and serotonin pathway genes: implications for association studies. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1070-5 pubmed publisher
    ..A list of tagSNPs per gene and continental region is proposed providing a guide for future association studies with these genes. ..
  57. Li H, Armando I, Yu P, Escano C, Mueller S, Asico L, et al. Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells. J Clin Invest. 2008;118:2180-9 pubmed publisher
    ..Our results therefore suggest that treatments for hypertension might be optimized by designing compounds that can target the AT1R and the D5R. ..
  58. Langley K, Fowler T, Grady D, Moyzis R, Holmans P, van den Bree M, et al. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. Eur Child Adolesc Psychiatry. 2009;18:26-32 pubmed publisher
    ..Association with variants at DRD4, DRD5, and the dopamine transporter gene, DAT was analyzed using linear regression...
  59. Sloan C, Shen L, West J, Wishart H, Flashman L, Rabin L, et al. Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1060-9 pubmed publisher
    ..The genes found in at least one cluster are ABCB1, APBA1, BACE1, BACE2, BCL2, BCL2L1, CASP7, CHAT, CST3, DRD3, DRD5, IL6, LRP1, NAT1, and PSEN2...
  60. Grandy D, Allen L, Zhang Y, Magenis R, Civelli O. Chromosomal localization of three human D5 dopamine receptor genes. Genomics. 1992;13:968-73 pubmed
    ..of PCR products from microdissected chromosomes, somatic cell hybrids, and radiation hybrids, we have assigned DRD5 (the locus containing the functional human D5 receptor gene) to chromosome 4p16...
  61. Sullivan P, Neale M, Silverman M, Harris Kerr C, Myakishev M, Wormley B, et al. An association study of DRD5 with smoking initiation and progression to nicotine dependence. Am J Med Genet. 2001;105:259-65 pubmed
    ..functional candidate genes and a linkage and an association study suggested that the type 5 dopamine receptor gene (DRD5) may be etiologically involved...
  62. Placzek M, Misbahuddin A, Chaudhuri K, Wood N, Bhatia K, Warner T. Cervical dystonia is associated with a polymorphism in the dopamine (D5) receptor gene. J Neurol Neurosurg Psychiatry. 2001;71:262-4 pubmed
    ..Further studies are required to confirm this finding and to assess whether these alleles are part of distinct haplotypes associated with other polymorphisms imparting a functional effect on the D5 receptor. ..
  63. Taurines R, Grunblatt E, Schecklmann M, Schwenck C, Albantakis L, Reefschläger L, et al. Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder. World J Biol Psychiatry. 2011;12 Suppl 1:104-8 pubmed publisher
    ..We analyzed mRNA-expression of monoaminergic candidate genes (DRD4, DRD5, TPH1) in peripheral tissue of patients with attention deficit hyperactivity disorder (ADHD) and autism spectrum ..
  64. Li D, Sham P, Owen M, He L. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum Mol Genet. 2006;15:2276-84 pubmed
    ..5 kb from the 5' end of dopamine receptor 5 gene (DRD5)...
  65. Zhang B, Yang X, Tiberi M. Functional importance of two conserved residues in intracellular loop 1 and transmembrane region 2 of Family A GPCRs: insights from ligand binding and signal transduction responses of D1 and D5 dopaminergic receptor mutants. Cell Signal. 2015;27:2014-25 pubmed publisher
    ..Our work thus potentially highlights a structural role of Thr59 and Ser65 in the formation of critical intramolecular interactions for ligand binding and signal transduction of D1-class dopaminergic receptors. ..
  66. Polymeropoulos M, Xiao H, Merril C. The human D5 dopamine receptor (DRD5) maps on chromosome 4. Genomics. 1991;11:777-8 pubmed
  67. Vanyukov M, Moss H, Kaplan B, Kirillova G, Tarter R. Antisociality, substance dependence, and the DRD5 gene: a preliminary study. Am J Med Genet. 2000;96:654-8 pubmed
    A pilot population-based study of a microsatellite polymorphism at the DRD5 locus in adult European-Americans showed its association with childhood symptom counts for oppositional defiant disorder (ODD) in males and females and adult ..
  68. Robaa D, Enzensperger C, Abul Azm S, El Khawass E, El Sayed O, Lehmann J. Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists. J Med Chem. 2010;53:2646-50 pubmed publisher
  69. Ke Y, Li W, Tan Z, Yang Z. Induction of dopamine D1 and D5 receptors in R28 cells by light exposures. Biochem Biophys Res Commun. 2017;486:686-692 pubmed publisher
    ..receptors were not detected in the total RNA preparations of all the cells, those of D1 and D5 receptors (DRD1 and DRD5) were induced by lighting in contrast to the dark control...
  70. Wang J, Liu Z, Chen B, Li J, Pan Y, Lu X, et al. Dopamine receptor gene polymorphisms in Guangzhou Hans. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2000;17:348-51 pubmed
    To determine the distribution of dopamine D2, D3, and D5 receptor(DRD2, DRD3, DRD5) gene polymorphisms in Guangzhou Hans...
  71. Hawi Z, Segurado R, Conroy J, Sheehan K, Lowe N, Kirley A, et al. Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. Am J Hum Genet. 2005;77:958-65 pubmed
    ..We have observed that several of these genes are associated with ADHD, including DAT1, DBH, DRD4, DRD5, and 5HT1B...
  72. Cosentino M, Colombo C, Mauri M, Ferrari M, Corbetta S, Marino F, et al. Expression of apoptosis-related proteins and of mRNA for dopaminergic receptors in peripheral blood mononuclear cells from patients with Alzheimer disease. Alzheimer Dis Assoc Disord. 2009;23:88-90 pubmed
    ..Levels of mRNA for DRD3 and DRD5 were similar in cells from healthy subjects and from AD patients...
  73. Gizer I, Ficks C, Waldman I. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet. 2009;126:51-90 pubmed publisher
    ..Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25...
  74. Hanami K, Nakano K, Tanaka Y. [Dopamine receptor signaling regulates human osteoclastogenesis]. Nihon Rinsho Meneki Gakkai Kaishi. 2013;36:35-9 pubmed
  75. Cunha V, Rodrigues P, Santos M, Moradas Ferreira P, Ferreira M. Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos. Chemosphere. 2018;191:954-961 pubmed publisher
    ..0015, 0.05, 0.1, 0.5 and 0.8 ?M) and mRNA levels of sert, 5-ht1a, 5-ht2c, dat, drd1b, drd2b, net, adra2a, adra2b, adra2c, vmat and mao were evaluated...
  76. Wang Q, Jolly J, Surmeier J, Mullah B, Lidow M, Bergson C, et al. Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase. J Biol Chem. 2001;276:39386-93 pubmed
  77. Hoogendoorn M, Bakker S, Schnack H, Selten J, Otten H, Verduijn W, et al. No association between 12 dopaminergic genes and schizophrenia in a large Dutch sample. Am J Med Genet B Neuropsychiatr Genet. 2005;134B:6-9 pubmed
    ..After correcting for multiple testing, significantly different allele frequencies were detected for DRD5 marker D4S615...
  78. Gildea J, Shah I, Van Sciver R, Israel J, Enzensperger C, McGrath H, et al. The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport. Kidney Int. 2014;86:118-26 pubmed publisher
    ..Thus, D1R and D5R interact in the inhibition of NHE3 and NaKATPase activity, the D1R primarily by cAMP, whereas the D1R/D5R heteromer modulates the D1R effect through a PLC pathway. ..
  79. Roosterman D. Agonist-dependent and -independent dopamine-1-like receptor signalling differentially regulates downstream effectors. FEBS J. 2014;281:4792-804 pubmed publisher
    ..Our data suggest that constitutive and agonist-induced activity of D5R differentially regulates the activity and expression of proteins. ..
  80. Xu Y, Chen X, Luo M, Tang Y, Zhang G, Wu D, et al. Multiple epigenetic factors predict the attention deficit/hyperactivity disorder among the Chinese Han children. J Psychiatr Res. 2015;64:40-50 pubmed publisher
    ..The expression levels of risk genes DAT1, DRD4, DRD5, as well as their promoter methylation, were determined respectively, followed by the expression profiles of ..
  81. Bobb A, Addington A, Sidransky E, Gornick M, Lerch J, Greenstein D, et al. Support for association between ADHD and two candidate genes: NET1 and DRD1. Am J Med Genet B Neuropsychiatr Genet. 2005;134B:67-72 pubmed
    ..in 12 previously studied candidate genes (5-HT1B, 5-HT2A, 5-HT2C, ADRA2A, CHRNA4, COMT, DAT1, DRD1, DRD4, DRD5, NET1, and SNAP-25)...
  82. Grant P, Gabriel F, Kuepper Y, Wielpuetz C, Hennig J. Psychosis-proneness correlates with expression levels of dopaminergic genes. Eur Psychiatry. 2014;29:304-6 pubmed publisher
    ..We found significant negative correlations regarding the expression of the genes COMT, MAOB, DRD4, DRD5 and FOS, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the ..
  83. Sherrington R, Mankoo B, Attwood J, Kalsi G, Curtis D, Buetow K, et al. Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1. Genomics. 1993;18:423-5 pubmed
    We identified a cosmid clone with exact sequence homology to part of the human dopamine D5 receptor gene (DRD5) after screening a cosmid library with the human DRD1 gene. The dopamine D5 receptor was mapped to chromosome 4p15.1-p15...
  84. Misbahuddin A, Placzek M, Warner T. Focal dystonia is associated with a polymorphism of the dopamine D5 receptor gene. Adv Neurol. 2004;94:143-6 pubmed
  85. Kim J, Waldman I, Faraone S, Biederman J, Doyle A, Purcell S, et al. Investigation of parent-of-origin effects in ADHD candidate genes. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:776-80 pubmed
    ..examined this phenomenon in a sample of 291 trios for five genes previously associated with ADHD (HTR1B, SNAP-25, DRD5, DAT1, and BDNF)...
  86. Langley K, Turic D, Rice F, Holmans P, van den Bree M, Craddock N, et al. Testing for gene x environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:49-53 pubmed
    ..In a clinical sample of 266 children with ADHD, we tested for interaction between gene variants (in DRD4, DAT1, DRD5, and 5HTT) found to be associated with ADHD in pooled analyses and maternal smoking, alcohol use during pregnancy ..
  87. Ikeda M, Yamanouchi Y, Kinoshita Y, Kitajima T, Yoshimura R, Hashimoto S, et al. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics. 2008;9:1437-43 pubmed publisher
    ..We conducted a pharmacogenetic study to evaluate whether variants in dopamine-related genes (DRD1-DRD5, AKT1 and GSK3beta) and serotonin receptor genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR2C, HTR6 and HTR7) can be used to ..
  88. Cosentino M, Zaffaroni M, Marino F. Levels of mRNA for dopaminergic receptor D₅ in circulating lymphocytes may be associated with subsequent response to interferon-β in patients with multiple sclerosis. J Neuroimmunol. 2014;277:193-6 pubmed publisher
    ..Lymphocyte DR D5 is reduced in MS and IFN-β restores their expression and responsiveness. DR D5 mRNA levels in circulating lymphocytes might represent an early marker of response to IFN-β in MS patients. ..
  89. Li Y, Shao C, Zhang D, Zhao M, Lin L, Yan P, et al. The effect of dopamine D2, D5 receptor and transporter (SLC6A3) polymorphisms on the cue-elicited heroin craving in Chinese. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:269-73 pubmed
    ..gene (DAT) SLC6A3 and with the dinucleotide repeat polymorphism (DRP) 148bp allele in D5 dopamine receptor gene (DRD5)...
  90. Sakihama T, Masuda K, Sato T, Doi T, Kodama T, Hamakubo T. Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system. J Biotechnol. 2008;135:28-33 pubmed publisher
    ..Since BV is essentially free of endogenous GPCRs, this BV co-display system should prove highly useful for the development of functional assay systems for GPCRs. ..