DRD3

Summary

Gene Symbol: DRD3
Description: dopamine receptor D3
Alias: D3DR, ETM1, FET1, D(3) dopamine receptor, essential tremor 1
Species: human
Products:     DRD3

Top Publications

  1. Jonsson E, Burgert E, Crocq M, Gustavsson J, Forslund K, Mattila Evenden M, et al. Association study between dopamine D3 receptor gene variant and personality traits. Am J Med Genet B Neuropsychiatr Genet. 2003;117B:61-5 pubmed
    ..We analyzed a dopamine D(3) receptor gene (DRD3) variant in a Swedish population (n = 373) investigated with one or more of several personality questionnaires...
  2. Vandenbergh D, O Connor R, Grant M, Jefferson A, Vogler G, Strasser A, et al. Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors. Addict Biol. 2007;12:106-16 pubmed
    ..smoking, like many addictive behaviors, has a genetic component, and the dopamine D2-like receptor genes (DRD2, DRD3 and DRD4) are candidates for contributing to these behaviors...
  3. Costas J, Carrera N, Dominguez E, Vilella E, Martorell L, Valero J, et al. A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia. Hum Genet. 2009;124:607-13 pubmed publisher
    ..we confirmed the existence of a common protective haplotype against schizophrenia at the dopamine D(3) receptor (DRD3) gene, by replication and pooled analysis with previous data (Mantel-Haenszel chi(2) P value = 0.00227; OR = 0...
  4. Hwang R, Zai C, Tiwari A, Muller D, Arranz M, Morris A, et al. Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant. Pharmacogenomics J. 2010;10:200-18 pubmed publisher
    ..We report a negative but consistent trend across individual studies in our meta-analysis for the DRD3 Ser allele and poor CLZ response...
  5. Sokoloff P, Giros B, Martres M, Bouthenet M, Schwartz J. Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature. 1990;347:146-51 pubmed
    ..It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors. ..
  6. Wang J, Liu Z, Chen B. Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD. Neurology. 2001;56:1757-9 pubmed
    ..b>DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations...
  7. Jonsson E, Flyckt L, Burgert E, Crocq M, Forslund K, Mattila Evenden M, et al. Dopamine D3 receptor gene Ser9Gly variant and schizophrenia: association study and meta-analysis. Psychiatr Genet. 2003;13:1-12 pubmed
    ..controversial putative association between a Ser9Gly variant in the first exon of the dopamine D3 receptor gene (DRD3) and schizophrenia...
  8. Novak G, LeBlanc M, Zai C, Shaikh S, Renou J, Deluca V, et al. Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia. Ann Hum Genet. 2010;74:291-8 pubmed publisher
    Emerging evidence indicates that the DRD1-BDNF-DRD3 cluster plays an important role in nicotine addiction...
  9. Dannlowski U, Domschke K, Birosova E, Lawford B, Young R, Voisey J, et al. Dopamine D? receptor gene variation: impact on electroconvulsive therapy response and ventral striatum responsiveness in depression. Int J Neuropsychopharmacol. 2013;16:1443-59 pubmed publisher
    ..Thus, the potential impact of dopamine D? receptor gene (DRD3) variation on ECT outcome in treatment-resistant major depression was evaluated by applying a combined molecular ..

More Information

Publications185 found, 100 shown here

  1. Shepherd A, Lea R, Hutchins C, Jordan K, Brimage P, Griffiths L. Dopamine receptor genes and migraine with and without aura: an association study. Headache. 2002;42:346-51 pubmed
    To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine. Migraine is a chronic debilitating disorder affecting approximately 12% of the white population...
  2. Pettersson Fernholm K, Forsblom C, Perola M, Fagerudd J, Groop P. Dopamine D3 receptor gene polymorphisms, blood pressure and nephropathy in type 1 diabetic patients. Nephrol Dial Transplant. 2004;19:1432-6 pubmed
    ..These results do not provide evidence for an involvement of the dopamine D3 receptor gene in blood pressure levels or in the pathogenesis of diabetic nephropathy in type 1 diabetic patients. ..
  3. Fiorentini C, Busi C, Gorruso E, Gotti C, Spano P, Missale C. Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Mol Pharmacol. 2008;74:59-69 pubmed publisher
    ..These data give a novel insight into how D1R and D3R may function in an integrated way, providing a molecular mechanism by which to converge D1R- and D3R-related dysfunctions. ..
  4. Liu Y, Tang B, Yan X, Liu J, Ouyang D, Nie L, et al. Association of the DRD2 and DRD3 polymorphisms with response to pramipexole in Parkinson's disease patients. Eur J Clin Pharmacol. 2009;65:679-83 pubmed publisher
    To evaluate the impact of the DRD2 TaqIA and DRD3 Ser9Gly polymorphisms on the efficacy of pramipexole in treating patients with Parkinson's disease (PD). Thirty patients with PD prospectively received pramipexole 0...
  5. Gasso P, Mas S, Bernardo M, Alvarez S, Parellada E, Lafuente A. A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. Pharmacogenomics J. 2009;9:404-10 pubmed publisher
    ..linkage disequilibrium mapping approach in seven-candidate genes with a well-established link to dopamine (DRD2, DRD3, ACE, COMT, DAT, MAO-A, MAO-B)...
  6. Muglia P, Jain U, Kennedy J. A transmission disequilibrium test of the Ser9/Gly dopamine D3 receptor gene polymorphism in adult attention-deficit hyperactivity disorder. Behav Brain Res. 2002;130:91-5 pubmed
    ..The dopamine D3 receptor gene (DRD3) represents a promising candidate to examine in ADHD...
  7. Lerer B, Segman R, Fangerau H, Daly A, Basile V, Cavallaro R, et al. Pharmacogenetics of tardive dyskinesia: combined analysis of 780 patients supports association with dopamine D3 receptor gene Ser9Gly polymorphism. Neuropsychopharmacology. 2002;27:105-19 pubmed
    ..an association between a serine (ser) to glycine (gly) polymorphism in exon 1 of the dopamine D3 receptor gene (DRD3) and TD; three failed to replicate this finding and one found an insignificant trend...
  8. Jeanneteau F, Funalot B, Jankovic J, Deng H, Lagarde J, Lucotte G, et al. A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. Proc Natl Acad Sci U S A. 2006;103:10753-8 pubmed
    ..Here, we report that the Ser9Gly variant in the dopamine D(3) receptor gene (DRD3), localized on 3q13.3, is associated and cosegregates with familial ET in 23 out of 30 French families...
  9. Bergen A, Conti D, Van Den Berg D, Lee W, Liu J, Li D, et al. Dopamine genes and nicotine dependence in treatment-seeking and community smokers. Neuropsychopharmacology. 2009;34:2252-64 pubmed publisher
    ..A community cohort of N=175 multiplex ever-smoking pedigrees (N=423 ever smokers) provided nominal evidence for association with the FTND at these top ranked SNPs, uncorrected for multiple comparisons. ..
  10. Chen P, Lao C, Chen J. The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5. J Neurochem. 2009;110:1180-90 pubmed publisher
  11. Savitz J, Hodgkinson C, Martin Soelch C, Shen P, Szczepanik J, Nugent A, et al. The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement. PLoS ONE. 2013;8:e54108 pubmed publisher
    ..Here we test the effect of a functional missense mutation in the dopamine 3 receptor (DRD3) gene (ser9gly, rs6280) on reward-associated dopamine (DA) release in the striatum...
  12. Stochino M, Asuni C, Congiu D, Del Zompo M, Severino G. Association study between the phenotype migraine without aura-panic disorder and dopaminergic receptor genes. Pharmacol Res. 2003;48:531-4 pubmed
    ..The allele frequencies of DRD1, DRD3, DRD5, DRD2 in probands did not differ from that of parental non-transmitted chromosomes...
  13. Czermak C, Lehofer M, Renger H, Wagner E, Lemonis L, Rohrhofer A, et al. Dopamine receptor D3 mRNA expression in human lymphocytes is negatively correlated with the personality trait of persistence. J Neuroimmunol. 2004;150:145-9 pubmed
    ..To test this "peripheral marker hypothesis", we compared mRNA expression of the dopamine receptors D3 (DRD3) and D4 (DRD4) in peripheral blood lymphocytes (PBL) to personality traits assessed with the Temperament and ..
  14. Chien E, Liu W, Zhao Q, KATRITCH V, Han G, Hanson M, et al. Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science. 2010;330:1091-5 pubmed publisher
    ..This difference provides direction to the design of D3R-selective agents for treating drug abuse and other neuropsychiatric indications. ..
  15. Huang W, Payne T, Ma J, Li M. A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1109-15 pubmed publisher
    ..We investigated 13 single nucleotide polymorphisms (SNPs) spanning a region of the dopamine D(3) receptor gene (DRD3) to determine whether DRD3 is associated with ND...
  16. Marcellino D, Ferre S, Casado V, Cortes A, Le Foll B, Mazzola C, et al. Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. J Biol Chem. 2008;283:26016-25 pubmed publisher
    ..The present study shows that a main functional significance of the D(3) receptor is to obtain a stronger dopaminergic response in the striatal neurons that co-express the two receptors. ..
  17. Pinna M, Manchia M, Oppo R, Scano F, Pillai G, Loche A, et al. Clinical and biological predictors of response to electroconvulsive therapy (ECT): a review. Neurosci Lett. 2018;669:32-42 pubmed publisher
    ..the brain-derived neurotrophic factor (BDNF), the dopamine 2 receptor gene (DRD2), the dopamine receptor 3 gene (DRD3), the cathechol-o-methyltransferase (COMT), the serotonin-transporter (5-HTT), the 5-hydroxytryptamine 2A receptor (..
  18. Bian Y, He X, Jing Y, Wang L, Wang J, Xie X. Computational systems pharmacology analysis of cannabidiol: a combination of chemogenomics-knowledgebase network analysis and integrated in silico modeling and simulation. Acta Pharmacol Sin. 2019;40:374-386 pubmed publisher
    ..Finally, the neurophysiological effects of CBD were illustrated at the molecular level, and dopamine receptor 3 (DRD3) was further predicted to be an active target for CBD.
  19. Qi X, Xuan J, Xing J, Wang B, Yao J. No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis. Neuropsychiatr Dis Treat. 2017;13:2855-2865 pubmed publisher
    Ser9Gly (rs6280) is a functional single-nucleotide polymorphism (SNP) in the dopamine receptor D3 (DRD3) gene that may be associated with schizophrenia...
  20. Zai C, Maes M, Tiwari A, Zai G, Remington G, Kennedy J. Genetics of tardive dyskinesia: Promising leads and ways forward. J Neurol Sci. 2018;389:28-34 pubmed publisher
    ..We therefore have reviewed the most promising genes associated with TD, including DRD2, DRD3, VMAT2, HSPG2, HTR2A, HTR2C, and SOD2...
  21. Molin A, Andrieux J, Koolen D, Malan V, Carella M, Colleaux L, et al. A novel microdeletion syndrome at 3q13.31 characterised by developmental delay, postnatal overgrowth, hypoplastic male genitals, and characteristic facial features. J Med Genet. 2012;49:104-9 pubmed publisher
    ..deleted region includes five RefSeq genes and two of them are strong candidate genes for the developmental delay: DRD3 and ZBTB20. A newly recognised 3q13...
  22. Guan X, Shi W, Zha S, Rong J, Su W, Liu G. Neurotoxic impact of acute TiO2 nanoparticle exposure on a benthic marine bivalve mollusk, Tegillarca granosa. Aquat Toxicol. 2018;200:241-246 pubmed publisher
    ..the expression of genes encoding modulatory enzymes (AChE, GABAT, and MAO) and receptors (mAChR3, GABAD, and DRD3) for the neurotransmitters tested were all significantly down-regulated after TiO2 NP exposure...
  23. Abe D, Doi H, Asai T, Kimura M, Wada T, Takahashi Y, et al. Association between COMT Val158Met polymorphism and competition results of competitive swimmers. J Sports Sci. 2018;36:393-397 pubmed publisher
    ..The investigated SNPs of DRD2 and DRD3 were not associated with swimmer's competitive performance...
  24. Dorokhov V, Puchkova A, Taranov A, Ermolayev V, Tupitsyna T, Slominsky P, et al. [Polymorphisms in Sleep and Cognitive Function Related Genes are Associated with Vehicle Crash History in Shift Working Bus Drivers]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2017;67:49-54 pubmed
    ..genes were genotyped: CLOCK (rs 12649507), RORA (rs1159814), NPAS2 (rs4851377), NPSR1 (rs324981), PER3 (rs2640909), DRD3 (rs6280), SLC6A3 (rs6347), DBH(rs1611125)...
  25. Hack L, Kalsi G, Aliev F, Kuo P, Prescott C, Patterson D, et al. Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). Alcohol Clin Exp Res. 2011;35:376-85 pubmed publisher
    ..However, false-positive findings remain possible, so our results must be interpreted with caution. ..
  26. Thomas P, Srivastava V, Singh A, Mathur P, Nimgaonkar V, Lerer B, et al. Correlates of response to Olanzapine in a North Indian Schizophrenia sample. Psychiatry Res. 2008;161:275-83 pubmed publisher
    ..Predictable covariates of treatment response were also noted. These results merit replicate studies. ..
  27. Derringer J, Krueger R, Dick D, Saccone S, Grucza R, Agrawal A, et al. Predicting sensation seeking from dopamine genes. A candidate-system approach. Psychol Sci. 2010;21:1282-90 pubmed publisher
  28. Warburton A, Savage A, Myers P, Peeney D, Bubb V, Quinn J. Molecular signatures of mood stabilisers highlight the role of the transcription factor REST/NRSF. J Affect Disord. 2015;172:63-73 pubmed publisher
    ..Global Pattern Recognition (GPR) analysis identified a total of 9 genes (DRD3(⁎), FOS(†), JUN(⁎), GAD1(⁎†), NRG1(⁎), PAFAH1B3(⁎), PER3(⁎), RELN(⁎) ..
  29. Cui Y, Prabhu V, Nguyen T, Yadav B, Chung Y. The mRNA Expression Status of Dopamine Receptor D2, Dopamine Receptor D3 and DARPP-32 in T Lymphocytes of Patients with Early Psychosis. Int J Mol Sci. 2015;16:26677-86 pubmed publisher
    ..Here, we measured the mRNA expression status of dopamine receptor D2 (DRD2), DRD3, and dopamine and cyclic adenosine 3',5'-monophosphate regulated phosphoprotein-32 (DARPP-32) in T lymphocytes of ..
  30. Seabrook G, Kemp J, Freedman S, Patel S, Sinclair H, McAllister G. Functional expression of human D3 dopamine receptors in differentiated neuroblastoma x glioma NG108-15 cells. Br J Pharmacol. 1994;111:391-3 pubmed
    ..These results demonstrate that human D3 receptors represent a functional class of dopamine receptor. ..
  31. Villar V, Jones J, Armando I, Palmes Saloma C, Yu P, Pascua A, et al. G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. J Biol Chem. 2009;284:21425-34 pubmed publisher
    ..These data demonstrate that GRK4, specifically the GRK4-gamma and GRK4-alpha isoforms, phosphorylates the D(3) receptor and is crucial for its signaling in human proximal tubule cells. ..
  32. Pou C, Mannoury La Cour C, Stoddart L, Millan M, Milligan G. Functional homomers and heteromers of dopamine D2L and D3 receptors co-exist at the cell surface. J Biol Chem. 2012;287:8864-78 pubmed publisher
    ..These data are of potential importance both to disorders in which D(2long) and D(3) receptors are implicated, like schizophrenia and Parkinson disease, and also to drugs exerting their actions via these sites. ..
  33. OZBURN A, Falcon E, Twaddle A, Nugent A, Gillman A, Spencer S, et al. Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2. Biol Psychiatry. 2015;77:425-433 pubmed publisher
    ..We identified the Drd3 dopamine receptor as a direct transcriptional target of NPAS2 and found that NPAS2 knockdown in the NAc disrupts ..
  34. Güzey C, Scordo M, Spina E, Landsem V, Spigset O. Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphisms. Eur J Clin Pharmacol. 2007;63:233-41 pubmed
    ..Little is known about the influence of polymorphisms of the dopamine and serotonin system on the risk for extrapyramidal symptoms (EPS) during treatment with antipsychotic drugs...
  35. Cote S, Kuzhikandathil E. Chronic levodopa treatment alters expression and function of dopamine D3 receptor in the MPTP/p mouse model of Parkinson's disease. Neurosci Lett. 2015;585:33-7 pubmed publisher
    ..b>drd3-EGFP reporter mice were injected biweekly with saline or MPTP and probenecid for a 5-week period...
  36. Papenberg G, Becker N, Ferencz B, Naveh Benjamin M, Laukka E, Backman L, et al. Dopamine Receptor Genes Modulate Associative Memory in Old Age. J Cogn Neurosci. 2017;29:245-253 pubmed publisher
    ..The effects of single-nucleotide polymorphisms of DA D1 (DRD1; rs4532), D2 (DRD2/ANKK1/Taq1A; rs1800497), and D3 (DRD3/Ser9Gly; rs6280) receptor genes were examined and combined into a single genetic score...
  37. Everett P, Senogles S. D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway. Neurosci Lett. 2004;371:34-9 pubmed
    ..PLD activation is a novel finding for the D(3) receptor, and is the first example of an effector system where D(3) signals without G(i)/G(o) protein intermediates. ..
  38. Srivastava V, Varma P, Prasad S, Semwal P, Nimgaonkar V, Lerer B, et al. Genetic susceptibility to tardive dyskinesia among schizophrenia subjects: IV. Role of dopaminergic pathway gene polymorphisms. Pharmacogenet Genomics. 2006;16:111-7 pubmed
    ..DRD4 and COMT genes were observed to be the most important candidates in North Indian schizophrenia subjects. These suggestive associations need to be investigated in replicate studies. ..
  39. Dai D, Cheng J, Zhou K, Lv Y, Zhuang Q, Zheng R, et al. Significant association between DRD3 gene body methylation and schizophrenia. Psychiatry Res. 2014;220:772-7 pubmed publisher
    The current study was the first one to reveal the contribution of DRD3 methylation to the risk of different (SCZ) subtypes...
  40. Nohesara S, Ghadirivasfi M, Barati M, Ghasemzadeh M, Narimani S, Mousavi Behbahani Z, et al. Methamphetamine-induced psychosis is associated with DNA hypomethylation and increased expression of AKT1 and key dopaminergic genes. Am J Med Genet B Neuropsychiatr Genet. 2016;171:1180-1189 pubmed publisher
    ..as control subjects (each group 25) were analyzed for expression and promoter DNA methylation status of DRD1, DRD2, DRD3, DRD4, MB-COMT, GAD1, and AKT1 using qRT-PCR and q-MSP, respectively...
  41. Segman R, Heresco Levy U, Finkel B, Inbar R, Neeman T, Schlafman M, et al. Association between the serotonin 2C receptor gene and tardive dyskinesia in chronic schizophrenia: additive contribution of 5-HT2Cser and DRD3gly alleles to susceptibility. Psychopharmacology (Berl). 2000;152:408-13 pubmed
    Tardive dyskinesia (TD) is a longterm adverse effect of dopamine receptor blockers. The dopamine D3 receptor gene (DRD3) ser9gly polymorphism has been previously associated with susceptibility to TD...
  42. Lee J, Cho J, Lee E, Park S, Jeon B. Differential genetic susceptibility in diphasic and peak-dose dyskinesias in Parkinson's disease. Mov Disord. 2011;26:73-9 pubmed publisher
    ..Genotyping was performed in the 503 patients and in 559 healthy controls to search for polymorphisms of DRD3 p.S9G, DRD2 Taq1A, GRIN2B c.2664C>T, c.366C>G, c.-200T>G, and the promoter region of SLC6A4...
  43. Huang H, Lee I, Chen K, Yeh T, Chen P, Yang Y, et al. Association of novelty seeking scores and striatal dopamine D?/D? receptor availability of healthy volunteers: single photon emission computed tomography with ¹²³i-iodobenzamide. J Formos Med Assoc. 2010;109:736-9 pubmed publisher
    ..25, p =0.07). A positive association was noted between the NS scores and left striatal D(2)/D(3) receptor availability (r= 0.29, p =0.04). The results suggest that a relationship might exist between NS score and dopaminergic activity. ..
  44. SanGiovanni J, Rosen R, Kaushal S. Application and interpretation of genome-wide association (GWA) studies for informing pharmacogenomic research - examples from the field of age-related macular degeneration. Curr Mol Med. 2014;14:814-32 pubmed
    ..SUCLA2, and GABBR2) and chromatin remodeling (HDAC9); and 2) Ropinirole and a geographic atrophy-associated gene (DRD3) with the capacity to alter systems involved in cAMP-PKA signaling...
  45. Paterson L, Flechais R, Murphy A, Reed L, Abbott S, Boyapati V, et al. The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description. J Psychopharmacol. 2015;29:943-60 pubmed publisher
    ..control task, and an evocative images task, using selective antagonists for µ-opioid, dopamine D3 receptor (DRD3) and neurokinin 1 (NK1) receptors (naltrexone, GSK598809, vofopitant/aprepitant), in a placebo-controlled, ..
  46. Chen C, Liu M, Wei F, Koong F, Hwu H, Hsiao K. Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia. Am J Med Genet. 1997;74:40-3 pubmed
    Dopamine D3 receptor (DRD3) was demonstrated to have important implications in schizophrenia, because it binds antipsychotic drugs and is abundant in the limbic system of the brain...
  47. Zai C, Hwang R, De Luca V, Muller D, King N, Zai G, et al. Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients. Int J Neuropsychopharmacol. 2007;10:639-51 pubmed
    ..The most consistent findings have been found with the Ser9Gly polymorphism of the DRD3 gene...
  48. Adams D, Close S, Farmen M, Downing A, Breier A, Houston J. Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder. Hum Psychopharmacol. 2008;23:267-74 pubmed publisher
    ..027). Gly/gly DRD-3 genotype predicted statistically and clinically significantly better acute positive symptom reduction compared with other ser-9-gly genotypes in patients treated with olanzapine. ..
  49. Bloemen O, de Koning M, Gleich T, Meijer J, De Haan L, Linszen D, et al. Striatal dopamine D2/3 receptor binding following dopamine depletion in subjects at Ultra High Risk for psychosis. Eur Neuropsychopharmacol. 2013;23:126-32 pubmed publisher
    ..Higher synaptic dopamine concentration was associated with more severe positive symptoms and a greater reduction of these symptoms following depletion. ..
  50. Krishnamoorthy S, Rajan R, Banerjee M, Kumar H, Sarma G, Krishnan S, et al. Dopamine D3 receptor Ser9Gly variant is associated with impulse control disorders in Parkinson's disease patients. Parkinsonism Relat Disord. 2016;30:13-7 pubmed publisher
    ..We investigated whether the allelic variants of dopamine (DRD3), glutamate (GRIN2B) and serotonin (HTR2A) receptors are linked to ICD in Indian Parkinson's disease (PD) patients...
  51. Xu Y, Wang J, Rao S, Ritter M, Manor L, Backer R, et al. An Integrative Computational Approach to Evaluate Genetic Markers for Bipolar Disorder. Sci Rep. 2017;7:6745 pubmed publisher
    ..g. GRIN2A, DRD1, DRD2, HTR2A, CACNA1C, TH, BDNF, SLC6A3, P2RX7, DRD3, and DRD4) and also highlighted several recently reported BP genes (e.g. GRIK5, GRM1 and CACNA1A)...
  52. Chen C, Hu X, Lin S, Sham P, Loh E, Li T, et al. Association analysis of dopamine D2-like receptor genes and methamphetamine abuse. Psychiatr Genet. 2004;14:223-6 pubmed
    ..Genetic polymorphisms of D2-like dopamine receptor genes, DRD2 TaqI A, DRD3 Ser-9-Gly, and DRD4 exon III variable number of tandem repeats, were compared between: (a) MAMP users as a whole ..
  53. Keri S, Juhász A, Rimanóczy A, Szekeres G, Kelemen O, Cimmer C, et al. Habit learning and the genetics of the dopamine D3 receptor: evidence from patients with schizophrenia and healthy controls. Behav Neurosci. 2005;119:687-93 pubmed
    ..study, the authors investigated the relationship between the Ser9Gly (SG) polymorphism of the dopamine D3 receptor (DRD3) and striatal habit learning in healthy controls and patients with schizophrenia...
  54. Gourion D, Goldberger C, Leroy S, Bourdel M, Olie J, Krebs M. Age at onset of schizophrenia: interaction between brain-derived neurotrophic factor and dopamine D3 receptor gene variants. Neuroreport. 2005;16:1407-10 pubmed
    ..Our findings show that this gene-gene interaction was significantly associated with an earlier emergence of psychosis by 3 years. ..
  55. Al Hadithy A, Wilffert B, Stewart R, Looman N, Bruggeman R, Brouwers J, et al. Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African-Caribbean inpatients: differences in association with dopamine and serotonin receptors. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:890-7 pubmed publisher
    We studied the association between polymorphisms of genes coding for dopamine D(2) (DRD2), dopamine D(3) (DRD3), serotonin 2(a) (HTR2A), and serotonin 2(c) (HTR2C) receptors and Antipsychotic-Induced Parkinsonism (AIP), rigidity, ..
  56. Utsunomiya K, Shinkai T, De Luca V, Hwang R, Sakata S, Fukunaka Y, et al. Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations: evidence from a case-control study and meta-analysis. Neurosci Lett. 2008;444:161-5 pubmed publisher
    ..Dopamine D3 receptors (DRD3) concentrated in limbic regions of the brain (important for cognitive, emotional and endocrine function) may be ..
  57. Zhang F, Fan H, Xu Y, Zhang K, Huang X, Zhu Y, et al. Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:613-9 pubmed publisher
    ..A glycine-to-serine polymorphism at codon 9 of the dopamine D3 receptor gene (DRD3), rs6280, has been widely studied for its association with SZ, but with conflicting results...
  58. Mannoury La Cour C, Salles M, Pasteau V, Millan M. Signaling pathways leading to phosphorylation of Akt and GSK-3? by activation of cloned human and rat cerebral D?and D? receptors. Mol Pharmacol. 2011;79:91-105 pubmed publisher
    ..However, significant differences were seen regarding the involvement of PLC, calmodulin, and ERK1/2. ..
  59. Chang T, Chen S, Chang Y, Chen P, Chu C, Chen S, et al. The DRD3 Ser9Gly Polymorphism Predicted Metabolic Change in Drug-Naive Patients With Bipolar II Disorder. Medicine (Baltimore). 2016;95:e3488 pubmed publisher
    ..The dopamine receptor D3 (DRD3) gene, one of the candidate genes for BDII, is also involved in the dopaminergic system...
  60. Purves Tyson T, Owens S, Rothmond D, Halliday G, Double K, Stevens J, et al. Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain. Transl Psychiatry. 2017;7:e1003 pubmed publisher
    ..monoamine transporter (VMAT2) and DAT mRNAs were significantly decreased in schizophrenia, with no change in DRD3 mRNA, DRD3nf mRNA and DAT protein between diagnostic groups...
  61. de Leon J, Susce M, Pan R, Koch W, Wedlund P. Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness. J Clin Psychopharmacol. 2005;25:448-56 pubmed
    ..2 cytochrome P450 (CYP) genes (CYP2D6 or CYP3A5), (b) 2 DRD2 variants (Ser311Cys and -141C Ins/del) and the Ser9Gly DRD3 variants, (c) 2 glutathione S-transferases (GSTT1 and GSTM1), and (d) variations in the PgP gene, MDR1...
  62. Urata T, Takahashi N, Hakamata Y, Iijima Y, Kuwahara N, Ozaki N, et al. Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis. Neurosci Lett. 2007;414:209-12 pubmed
    ..The present study investigated the relationship between the specific polymorphisms of MAO-A, COMT, DRD2, DRD3 and personality traits in Japanese women using a novel genotyping method involving electrochemical DNA array (ECA) ..
  63. Fathalli F, Rouleau G, Xiong L, Tabbane K, Benkelfat C, DeGuzman R, et al. No association between the DRD3 Ser9Gly polymorphism and schizophrenia. Schizophr Res. 2008;98:98-104 pubmed
    To investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia...
  64. Wolf E, Mitchell K, Logue M, Baldwin C, Reardon A, Aiello A, et al. The dopamine D3 receptor gene and posttraumatic stress disorder. J Trauma Stress. 2014;27:379-87 pubmed publisher
    The dopamine D3 receptor (DRD3) gene has been implicated in schizophrenia, autism, and substance use-disorders and is related to emotion reactivity, executive functioning, and stress-responding, processes impaired in posttraumatic stress ..
  65. Okita K, Mandelkern M, London E. Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
    ..The results suggest an effect of smoking on ventral striatal D2/3 dopamine receptors that may contribute to nicotine dependence. ..
  66. Robinson S, Caron M. Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells. J Neurochem. 1996;67:212-9 pubmed
  67. Joober R, Toulouse A, Benkelfat C, Lal S, Bloom D, Labelle A, et al. DRD3 and DAT1 genes in schizophrenia: an association study. J Psychiatr Res. 2000;34:285-91 pubmed
    To investigate the role of the dopamine receptor 3 (DRD3) and transporter 1 (DAT1) genes in schizophrenia or in modulating its phenotype...
  68. Kabbani N, Negyessy L, Lin R, Goldman Rakic P, Levenson R. Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. J Neurosci. 2002;22:8476-86 pubmed
    ..NCS-1-D2 receptor interaction may serve to couple dopamine and calcium signaling pathways, thereby providing a critical component in the regulation of dopaminergic signaling in normal and diseased brain. ..
  69. Zhang Z, Hou G, Zhang X, Yao H, Sha W, Zhang X. [Pharmacogenetic assessment of antipsychotic-induced tardive dyskinesia: contribution of 5-hydroxytryptamine 2C receptor gene and of a combination of dopamine D3 variant allele (Gly) and MnSOD wild allele (Val)]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20:98-102 pubmed
    To further investigate whether the functional polymorphisms of dopamine D2 receptor (DRD2) and dopamine D3 receptor (DRD3) genes associate with the development of tardive dyskinesia (TD) in schizophrenia, and whether the interactive ..
  70. Ton T, Rossing M, Bowen D, Srinouanprachan S, Wicklund K, Farin F. Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. Behav Brain Funct. 2007;3:22 pubmed
    ..in genes involved in dopamine synthesis (tyrosine hydroxylase [TH]), receptor activation (dopamine receptors [DRD2, DRD3, DRD4]), reuptake (dopamine transporter [SLC6A3]), and metabolism (catechol-o-methyltransferase [COMT])...
  71. Ballon N, Leroy S, Roy C, Bourdel M, Olie J, Charles Nicolas A, et al. Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents?. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:1034-41 pubmed
    ..The potential association of the variants TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT was examined in African-Caribbean males, smoked-cocaine ..
  72. Muller D, Zai C, Sicard M, Remington E, Souza R, Tiwari A, et al. Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain. Pharmacogenomics J. 2012;12:156-64 pubmed publisher
    ..The other genes were primarily negative. We provide evidence that dopamine receptor DRD2 gene variants might be associated with antipsychotic-induced weight gain in chronic schizophrenia patients. ..
  73. Munafò M, Clark T, Moore L, Payne E, Walton R, Flint J. Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis. Mol Psychiatry. 2003;8:471-84 pubmed
    ..fixed-effects model suggested significant associations between the 5HTT LPR, DRD4 c>t, DRD4 length, DRD2 A1/A2, DRD3 A1/A2 polymorphisms and personality traits...
  74. Szekeres G, Keri S, Juhász A, Rimanóczy A, Szendi I, Czimmer C, et al. Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004;124B:1-5 pubmed
    ..In this study, we investigated the relationship of the Ser9Gly (S/G) polymorphism of the dopamine D3 receptor (DRD3) and the variable number of tandem repeats (VNTR) polymorphism of the dopamine transporter (DAT) with therapeutic ..
  75. Lin C, Lee S, Chang Y, Wu J, Wu Y, Wu P, et al. Temperamentsxgenes in bipolar I and bipolar II disorder patients. Psychiatry Res. 2010;177:364-6 pubmed publisher
    ..This study provided evidence that differences existed between BP-I and BPII in gene and temperament interactions. ..
  76. Min C, Zheng M, Zhang X, Guo S, Kwon K, Shin C, et al. N-linked Glycosylation on the N-terminus of the dopamine D2 and D3 receptors determines receptor association with specific microdomains in the plasma membrane. Biochim Biophys Acta. 2015;1853:41-51 pubmed publisher
    ..These data suggest that changes in the cellular environment that influence posttranslational modification could be an important determinant of intracellular GPCR trafficking. ..
  77. Oldenhof J, Ray A, Vickery R, Van Tol H. SH3 ligands in the dopamine D3 receptor. Cell Signal. 2001;13:411-6 pubmed
    ..Disruption of the PXXP motifs in the D3 receptor did not affect the interaction with Grb2. These results indicate that GPCRs may contain SH3 ligands that do not contain the postulated minimal consensus sequence PXXP. ..
  78. Kim K, Gainetdinov R, Laporte S, Caron M, Barak L. G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. J Biol Chem. 2005;280:12774-80 pubmed
    ..These findings provide a novel GRK-based mechanism for regulating D3R signaling potential and provide insight for interpreting D3R autoreceptor behavior. ..
  79. Wiesbeck G, Dursteler MacFarland K, Wurst F, Walter M, Petitjean S, Muller S, et al. No association of dopamine receptor sensitivity in vivo with genetic predisposition for alcoholism and DRD2/DRD3 gene polymorphisms in alcohol dependence. Addict Biol. 2006;11:72-5 pubmed
    ..to explore whether this sensitivity might be associated with functional variations of dopamine D2 (DRD2) and D3 (DRD3) receptor genes along with a genetic predisposition for alcoholism as reflected by an alcohol-dependent first-..
  80. Prasad P, Kumar K, Ammini A, Gupta A, Gupta R, Thelma B. Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. BMC Genet. 2008;9:26 pubmed publisher
    ..Genetic association of 12 polymorphisms (SNPs) from five genes namely-dopamine receptor-1 (DRD1), DRD2, DRD3, DRD4, andcatechol-O-methyltransferase (COMT) with diabetic CRI was investigated using a case-control approach...
  81. Lorenz D, Klebe S, Stevanin G, Thier S, Nebel A, Feingold J, et al. Dopamine receptor D3 gene and essential tremor in large series of German, Danish and French patients. Eur J Hum Genet. 2009;17:766-73 pubmed publisher
    ..has been found associated with a functional variant (Ser9Gly) of the dopamine D(3) receptor (DRD3), located in the ETM1 locus on chromosome 3q13.3 described for the first time in 1997...
  82. Cosentino M, Zaffaroni M, Legnaro M, Bombelli R, Schembri L, Baroncini D, et al. Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis. J Neuroimmunol. 2016;298:82-9 pubmed publisher
    ..Results show the involvement of dopaminergic and adrenergic pathways in CIS as well as in MS pathogenesis, supporting the evaluation of dopaminergic and adrenergic agents in MS. ..
  83. Seeman P, Guan H, Van Tol H. Dopamine D4 receptors elevated in schizophrenia. Nature. 1993;365:441-5 pubmed
  84. Newton C, Wood M, Strange P. Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors. PLoS ONE. 2016;11:e0158808 pubmed publisher
  85. Nakajima S, Gerretsen P, Takeuchi H, Caravaggio F, Chow T, Le Foll B, et al. The potential role of dopamine D₃ receptor neurotransmission in cognition. Eur Neuropsychopharmacol. 2013;23:799-813 pubmed publisher
    ..Clinical trials are needed to confirm these effects. ..
  86. Kuo S, Yeh Y, Chen C, Huang C, Chang H, Yen C, et al. DRD3 variation associates with early-onset heroin dependence, but not specific personality traits. Prog Neuropsychopharmacol Biol Psychiatry. 2014;51:1-8 pubmed publisher
    ..The aim of this study was to examine whether the corresponding gene, DRD3, is associated with the development of heroin dependence and specific personality traits in HD patients...
  87. Pagerols M, Richarte V, Sánchez Mora C, Garcia Martinez I, Corrales M, Corominas M, et al. Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder. Pharmacogenomics J. 2017;17:98-104 pubmed publisher
    ..Our results provide evidence for the contribution of DRD3 (P=0.041; odds ratio (OR)=4.00), DBH (P=0.032; OR=2.85), TH (P=5.5e-03; OR=4.34) and prenatal smoking (P=1...
  88. Tsai S, Yu Y, Chen T, Chen M, Hong C. Association analysis for dopamine D3 receptor, dopamine D4 receptor and dopamine transporter genetic polymorphisms and P300 event-related potentials for normal young females. Psychiatr Genet. 2003;13:51-3 pubmed
    ..Our negative findings suggest that these genetic polymorphisms do not play a major role in the modulation of P300 event-related potentials. ..
  89. Lorenzo C, Baca Garcia E, Hernandez M, Martin C, Perez Rodriguez M, Saiz Gonzalez M, et al. No association between the Ser9Gly polymorphism of the dopamine D3 receptor gene and schizophrenia in a Spanish sample. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:344-6 pubmed
    ..the controversial association between the Ser9Gly polymorphism in codon 9 of the D3 dopamine receptor gene (DRD3) and schizophrenia in psychiatric inpatients acutely hospitalized in two general hospitals in Madrid, Spain...