Gene Symbol: DRD1
Description: dopamine receptor D1
Alias: DADR, DRD1A, D(1A) dopamine receptor, dopamine D1 receptor
Species: human
Products:     DRD1

Top Publications

  1. Gahete M, Rubio A, Duran Prado M, Avila J, Luque R, Castaño J. Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients. J Alzheimers Dis. 2010;20:465-75 pubmed publisher
    ..we measured by quantitative real-time PCR the mRNA levels of SST/CST, their receptors (sst1-5 and DA receptors (drd1-5) in addition to neprilysin (a SST-regulated enzyme involved in Abeta degradation) in three regions of the ..
  2. Marcellino D, Ferre S, Casado V, Cortes A, Le Foll B, Mazzola C, et al. Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. J Biol Chem. 2008;283:26016-25 pubmed publisher
    ..The present study shows that a main functional significance of the D(3) receptor is to obtain a stronger dopaminergic response in the striatal neurons that co-express the two receptors. ..
  3. Zhu F, Yan C, Wang Q, Zhu Y, Zhao Y, Huang J, et al. An association study between dopamine D1 receptor gene polymorphisms and the risk of schizophrenia. Brain Res. 2011;1420:106-13 pubmed publisher
    ..Genetic polymorphisms in functional regions of DRD1 have a plausible role in modulating the risk of schizophrenia...
  4. Bermak J, Li M, Bullock C, Zhou Q. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat Cell Biol. 2001;3:492-8 pubmed
    ..FxxxFxxxF, which is highly conserved among GPCRs, functions independently as an ER-export signal for the dopamine D1 receptor. A newly identified ER-membrane-associated protein, DRiP78, binds to this motif...
  5. Albrecht F, Drago J, Felder R, Printz M, Eisner G, Robillard J, et al. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. J Clin Invest. 1996;97:2283-8 pubmed
  6. Stochino M, Asuni C, Congiu D, Del Zompo M, Severino G. Association study between the phenotype migraine without aura-panic disorder and dopaminergic receptor genes. Pharmacol Res. 2003;48:531-4 pubmed
    ..The allele frequencies of DRD1, DRD3, DRD5, DRD2 in probands did not differ from that of parental non-transmitted chromosomes...
  7. Batel P, Houchi H, Daoust M, Ramoz N, Naassila M, Gorwood P. A haplotype of the DRD1 gene is associated with alcohol dependence. Alcohol Clin Exp Res. 2008;32:567-72 pubmed publisher
    ..Indeed, DRD1 antagonists may reduce cocaine-seeking behavior and the acquisition of cocaine-cue associations. The D1...
  8. Gildea J, Wang X, Jose P, Felder R. Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor. Hypertension. 2008;51:360-6 pubmed publisher
    ..The discovery of differential regulation by D(1)R and D(5)R opens new avenues for the development of agonists selective to either receptor subtype as targeted antihypertensive agents that can decrease AT(1)R-mediated antinatriuresis. ..
  9. Chun L, Free R, Doyle T, Huang X, Rankin M, Sibley D. D1-D2 dopamine receptor synergy promotes calcium signaling via multiple mechanisms. Mol Pharmacol. 2013;84:190-200 pubmed publisher
    ..In addition, SKF83959 may not exhibit selective activation of D(1)-D(2) heteromers, and its significant cross-reactivity to other receptors warrants careful interpretation of its use in vivo. ..

More Information


  1. Shepherd A, Lea R, Hutchins C, Jordan K, Brimage P, Griffiths L. Dopamine receptor genes and migraine with and without aura: an association study. Headache. 2002;42:346-51 pubmed
    To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine. Migraine is a chronic debilitating disorder affecting approximately 12% of the white population...
  2. Rieckmann A, Karlsson S, Karlsson P, Brehmer Y, Fischer H, Farde L, et al. Dopamine D1 receptor associations within and between dopaminergic pathways in younger and elderly adults: links to cognitive performance. Cereb Cortex. 2011;21:2023-32 pubmed publisher
  3. Gildea J, Wang X, Shah N, Tran H, Spinosa M, Van Sciver R, et al. Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. Hypertension. 2012;60:396-403 pubmed publisher
    ..These studies shed new light on the regulation of renal sodium transport by the dopaminergic and angiotensin systems and potential new therapeutic targets for selectively treating hypertension. ..
  4. Huang W, Ma J, Payne T, Beuten J, Dupont R, Li M. Significant association of DRD1 with nicotine dependence. Hum Genet. 2008;123:133-40 pubmed
    ..this study, we examined five single-nucleotide polymorphisms (SNPs) within or near the dopamine D(1) receptor gene (DRD1) for their association with ND, which was assessed by smoking quantity (SQ), the Heaviness of Smoking Index (HSI), ..
  5. Rashid A, So C, Kong M, Furtak T, El Ghundi M, Cheng R, et al. D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci U S A. 2007;104:654-9 pubmed
  6. Kim D, Park B, Yoon S, Lee H, Joe K, Cheon Y, et al. 5' UTR polymorphism of dopamine receptor D1 (DRD1) associated with severity and temperament of alcoholism. Biochem Biophys Res Commun. 2007;357:1135-41 pubmed
    ..To examine the genetic effects of the Dopamine Receptor D1 (DRD) gene family (DRD1-DRD5) in the Korean population, 11 polymorphisms in the DRD gene family were genotyped and analyzed in 535 alcohol-..
  7. Fiorentini C, Busi C, Gorruso E, Gotti C, Spano P, Missale C. Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Mol Pharmacol. 2008;74:59-69 pubmed publisher
    ..These data give a novel insight into how D1R and D3R may function in an integrated way, providing a molecular mechanism by which to converge D1R- and D3R-related dysfunctions. ..
  8. Hettinger J, Liu X, Schwartz C, Michaelis R, Holden J. A DRD1 haplotype is associated with risk for autism spectrum disorders in male-only affected sib-pair families. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:628-36 pubmed publisher
    ..Because the dopamine D1 receptor (encoded by DRD1) is integral to the neural circuitry mediating these processes, we examined the DRD1 gene ..
  9. Beige J, Bellmann A, Sharma A, Gessner R. Ethnic origin determines the impact of genetic variants in dopamine receptor gene (DRD1) concerning essential hypertension. Am J Hypertens. 2004;17:1184-7 pubmed
    The dopamine receptor type 1 (DRD1) has been implicated in the development of hypertension in humans as well as in animal models of spontaneous hypertension...
  10. Yu P, Yang Z, Jones J, Wang Z, Owens S, Mueller S, et al. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 2004;66:2167-80 pubmed
    ..The majority of hD1Rs are distributed in lipid rafts. Heterologously and endogenously expressed D1Rs in renal cells are associated with and regulated by caveolin-2. ..
  11. Takahashi H, Kato M, Takano H, Arakawa R, Okumura M, Otsuka T, et al. Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functions. J Neurosci. 2008;28:12032-8 pubmed publisher
    ..Our findings suggest that orchestration of prefrontal D(1) receptors and hippocampal D(2) receptors might be necessary for human executive function including working memory. ..
  12. Prasad P, Kumar K, Ammini A, Gupta A, Gupta R, Thelma B. Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. BMC Genet. 2008;9:26 pubmed publisher
    ..Genetic association of 12 polymorphisms (SNPs) from five genes namely-dopamine receptor-1 (DRD1), DRD2, DRD3, DRD4, andcatechol-O-methyltransferase (COMT) with diabetic CRI was investigated using a case-control ..
  13. d Emmanuele di Villa Bianca R, Sorrentino R, Roviezzo F, Imbimbo C, Palmieri A, De Dominicis G, et al. Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips. Int J Impot Res. 2005;17:127-33 pubmed
  14. Missale C, Nash S, Robinson S, Jaber M, Caron M. Dopamine receptors: from structure to function. Physiol Rev. 1998;78:189-225 pubmed
    ..However, targeted deletion of several of these dopamine receptor genes in mice should provide valuable information about their physiological functions...
  15. da Silva Lobo D, Vallada H, Knight J, Martins S, Tavares H, Gentil V, et al. Dopamine genes and pathological gambling in discordant sib-pairs. J Gambl Stud. 2007;23:421-33 pubmed
    ..of the dopaminergic system in addictions and impulse control disorders and associations of dopamine receptor genes (DRD1, DRD2, and DRD4) and PG have been reported...
  16. Vargas G, von Zastrow M. Identification of a novel endocytic recycling signal in the D1 dopamine receptor. J Biol Chem. 2004;279:37461-9 pubmed
  17. Koks S, Nikopensius T, Koido K, Maron E, Altmäe S, Heinaste E, et al. Analysis of SNP profiles in patients with major depressive disorder. Int J Neuropsychopharmacol. 2006;9:167-74 pubmed
    ..SNPs in CCKAR, DRD1, DRD2, and HTR2C genes showed nominally significant associations with MDD...
  18. Dmitrzak Weglarz M, Rybakowski J, Slopien A, Czerski P, Leszczynska Rodziewicz A, Kapelski P, et al. Dopamine receptor D1 gene -48A/G polymorphism is associated with bipolar illness but not with schizophrenia in a Polish population. Neuropsychobiology. 2006;53:46-50 pubmed
    ..The dopamine D(1) receptor (DRD1) plays a role in some brain functions and mechanisms of psychotropic drugs...
  19. Limosin F, Loze J, Rouillon F, Ades J, Gorwood P. Association between dopamine receptor D1 gene DdeI polymorphism and sensation seeking in alcohol-dependent men. Alcohol Clin Exp Res. 2003;27:1226-8 pubmed
    ..We investigated whether the DRD1 DdeI polymorphism could be associated with the sensation-seeking level among a sample of 72 alcohol-dependent male ..
  20. Jin H, Xie Z, George S, O Dowd B. Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor. Eur J Pharmacol. 1999;386:305-12 pubmed
  21. Free R, Hazelwood L, Cabrera D, Spalding H, Namkung Y, Rankin M, et al. D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin. J Biol Chem. 2007;282:21285-300 pubmed
    ..Our data suggest that optimal receptor-calnexin interactions critically regulate D(1) and D(2) receptor trafficking and expression at the cell surface, a mechanism likely to be of importance for many GPCRs. ..
  22. Severino G, Congiu D, Serreli C, De Lisa R, Chillotti C, Del Zompo M, et al. A48G polymorphism in the D1 receptor genes associated with bipolar I disorder. Am J Med Genet B Neuropsychiatr Genet. 2005;134B:37-8 pubmed
    ..In line with a considerable amount of evidence, the dopamine D1 receptor gene (DRD1) is considered to be a good candidate gene for bipolar disorders...
  23. Cao F, Souders C, Li P, Pang S, Liang X, Qiu L, et al. Developmental neurotoxicity of maneb: Notochord defects, mitochondrial dysfunction and hypoactivity in zebrafish (Danio rerio) embryos and larvae. Ecotoxicol Environ Saf. 2019;170:227-237 pubmed publisher
    ..sod1 and sod2), nor those related to dopamine synthesis (th1), dopamine transporter (dat), dopamine receptors (drd1, drd2a, drd3, and drd4b)...
  24. OZBURN A, Falcon E, Twaddle A, Nugent A, Gillman A, Spencer S, et al. Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2. Biol Psychiatry. 2015;77:425-433 pubmed publisher
    ..Furthermore, we found that NPAS2 expression is restricted to Drd1 expressing neurons while CLOCK is ubiquitous...
  25. Gao L, Feng S, Liu Z, Wang J, Qi K, Wang K. A computational network analysis based on targets of antipsychotic agents. Schizophr Res. 2018;193:154-160 pubmed publisher
    ..significant brain region specific target-drug interactions were identified in targets of dopamine receptors (DRD1-Olanzapine in caudate nucleus and pons (P-value<0...
  26. Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, et al. Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease. Clin Exp Nephrol. 2016;20:218-25 pubmed publisher
    ..mRNA expression levels of GABA receptor (GABBR2), noradrenaline receptor (ADRA1A), dopamine receptor (DRD1) and histamine receptor (HRH1) showed an inverse correlation with renal function...
  27. MacDonald S, Karlsson S, Rieckmann A, Nyberg L, Backman L. Aging-related increases in behavioral variability: relations to losses of dopamine D1 receptors. J Neurosci. 2012;32:8186-91 pubmed publisher
    ..These findings suggest that dysfunctional DA modulation may contribute to increased variability in cognitive performance among older adults. ..
  28. Katidou M, Grosmaitre X, Lin J, Mombaerts P. G-protein coupled receptors Mc4r and Drd1a can serve as surrogate odorant receptors in mouse olfactory sensory neurons. Mol Cell Neurosci. 2018;88:138-147 pubmed publisher
    ..gene-targeted mouse strains in which the mouse melanocortin 4 receptor (Mc4r) or the mouse dopamine receptor D1 (Drd1a) is coexpressed with tauGFP in OSNs that express the OR locus M71...
  29. Novak G, LeBlanc M, Zai C, Shaikh S, Renou J, Deluca V, et al. Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia. Ann Hum Genet. 2010;74:291-8 pubmed publisher
    Emerging evidence indicates that the DRD1-BDNF-DRD3 cluster plays an important role in nicotine addiction...
  30. Eisenberg D, Campbell B, MacKillop J, Lum J, Wilson D. Season of birth and dopamine receptor gene associations with impulsivity, sensation seeking and reproductive behaviors. PLoS ONE. 2007;2:e1216 pubmed
    ..These findings suggest that SOB should be included in future studies of risky behaviors and behavioral genetic studies of the dopamine system. ..
  31. González C, González B, Matzkin M, Muñiz J, Cadet J, Garcia Rill E, et al. Psychostimulant-Induced Testicular Toxicity in Mice: Evidence of Cocaine and Caffeine Effects on the Local Dopaminergic System. PLoS ONE. 2015;10:e0142713 pubmed publisher
    ..Moreover, using transgenic BAC-Drd1a-tdTomato and D2R-eGFP mice, we report for the first time the presence of dopamine receptors (DRs) D1 and D2 in ..
  32. Tupala E, Tiihonen J. Striatal dopamine D1 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography. Brain Res. 2005;1031:20-9 pubmed
  33. Plouffe B, Yang X, Tiberi M. The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner. Cell Signal. 2012;24:106-18 pubmed publisher
    ..Overall, our results strongly suggest that IL3 is the critical determinant underlying the subtype-specific regulation of human D1-like receptor responsiveness by PKC. ..
  34. Juhasz J, Hasbi A, Rashid A, So C, George S, O Dowd B. Mu-opioid receptor heterooligomer formation with the dopamine D1 receptor as directly visualized in living cells. Eur J Pharmacol. 2008;581:235-43 pubmed publisher
    Our immunohistochemistry experiments demonstrated that the mu-opioid receptor co-localized with the dopamine D1 receptor in neurons of the cortex and caudate nucleus...
  35. Garcia A, Depena C, Bezner K, Yin W, Gore A. The timing and duration of estradiol treatment in a rat model of the perimenopause: Influences on social behavior and the neuromolecular phenotype. Horm Behav. 2018;97:75-84 pubmed publisher
    ..for genes involved in regulating social behavior such as neuropeptides (Oxt, Oxtr &Avp), neurotransmitters (Drd1, Drd2, Htr2a, Grin2d &Gabbr1), and steroid hormone receptors (Esr2, Ar, Pgr)...
  36. Larese T, Yan Y, Eipper B, Mains R. Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors. BMC Neurosci. 2017;18:45 pubmed publisher
    ..expressing neurons produced a transient enhancement of cocaine-induced locomotion, while knockout of Kalirin in Drd1a- or Drd2-dopamine receptor expressing neurons was without effect...
  37. Knowles M, de la Tremblaye P, Azogu I, Plamondon H. Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity. Prog Neuropsychopharmacol Biol Psychiatry. 2016;66:8-21 pubmed publisher
    ..hormone (CRH), vesicular glutamate transporter 2 (vGluT2), tyrosine hydroxylase (TH) and dopamine receptor 1 (DRD1) signaling expression, together with CA1 neuronal damage and anxiety-like behaviors were assessed...
  38. Zhang K, Chammas C, Soghomonian J. Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience. 2015;303:586-94 pubmed publisher
    ..In light of evidence that the dopamine Drd1a receptor is densely expressed in striatal direct pathway striatal neurons while the orphan G-protein-coupled ..
  39. Pardini M, Krueger F, Hodgkinson C, Raymont V, Strenziok M, Amore M, et al. Aggression, DRD1 polymorphism, and lesion location in penetrating traumatic brain injury. CNS Spectr. 2014;19:382-90 pubmed publisher
    ..Participants were genotyped for 3 functional single nucleotide polymorphisms (SNPs): dopamine receptor D1 (DRD1) rs686, dopamine receptor D2 (DRD2) rs4648317, and catechol-O-methyltransferase (COMT) Val158Met...
  40. Fujiwara H, Ito H, Kodaka F, Kimura Y, Takano H, Suhara T. Association between striatal subregions and extrastriatal regions in dopamine D(1) receptor expression: a positron emission tomography study. PLoS ONE. 2012;7:e49775 pubmed publisher
  41. Mileva Seitz V, Fleming A, Meaney M, Mastroianni A, Sinnwell J, Steiner M, et al. Dopamine receptors D1 and D2 are related to observed maternal behavior. Genes Brain Behav. 2012;11:684-94 pubmed publisher
    The dopamine pathway and especially the dopamine receptors 1 and 2 (DRD1 and DRD2) are implicated in the regulation of mothering in rats. Evidence for this in humans is lacking...
  42. Luo R, Li X, Qin S, Luo Z, Luo X, Hu P, et al. Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. Pharmacogenomics. 2017;: pubmed publisher
    To evaluate the potential association of the genetic polymorphisms in ABCB1, ARRB2, DRD1 and OPRD1 genes with methadone dosage requirement among Han Chinese opioid-dependent patients.
  43. Robaa D, Enzensperger C, Abul Azm S, El Khawass E, El Sayed O, Lehmann J. Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists. J Med Chem. 2010;53:2646-50 pubmed publisher
  44. Misener V, Luca P, Azeke O, Crosbie J, Waldman I, Tannock R, et al. Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder. Mol Psychiatry. 2004;9:500-9 pubmed
    ..has a strong genetic basis, and evidence from human and animal studies suggests the dopamine receptor D1 gene, DRD1, to be a good candidate for involvement...
  45. Hack L, Kalsi G, Aliev F, Kuo P, Prescott C, Patterson D, et al. Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). Alcohol Clin Exp Res. 2011;35:376-85 pubmed publisher
    ..We conducted an association study on the products encoded by 10 DA-related genes (DRD1-D5, SLC18A2, SLC6A3, DDC, TH, COMT) using a large, ethnically homogeneous sample with severe AD (n = 545) and ..
  46. Sarty K, Cowie A, Martyniuk C. The legacy pesticide dieldrin acts as a teratogen and alters the expression of dopamine transporter and dopamine receptor 2a in zebrafish (Danio rerio) embryos. Comp Biochem Physiol C Toxicol Pharmacol. 2017;194:37-47 pubmed publisher
    ..Lastly, GABAA receptor subunits gabrB1 and gabrB2, as well as dopamine receptors drd1 and drd2a, were inherently higher in abundance in dechorionated embryos compared to chorionated embryos...
  47. Beste C, Stock A, Epplen J, Arning L. Dissociable electrophysiological subprocesses during response inhibition are differentially modulated by dopamine D1 and D2 receptors. Eur Neuropsychopharmacol. 2016;26:1029-36 pubmed publisher
    ..We, therefore, investigated this question by examining the effects of DRD1 (rs4532) and DRD2 (rs6277) receptor polymorphisms on electrophysiological correlates of response inhibition ..
  48. Lobo D, Souza R, Tong R, Casey D, Hodgins D, Smith G, et al. Association of functional variants in the dopamine D2-like receptors with risk for gambling behaviour in healthy Caucasian subjects. Biol Psychol. 2010;85:33-7 pubmed publisher
    ..We evaluated the association of genetic variants in the dopaminergic receptor genes (DRD1-3s) with risk for gambling in healthy subjects using the Canadian Problem Gambling Index (CPGI)...
  49. Stock A, Arning L, Epplen J, Beste C. DRD1 and DRD2 genotypes modulate processing modes of goal activation processes during action cascading. J Neurosci. 2014;34:5335-41 pubmed publisher
    ..and cascading can be accomplished in a serial manner or a parallel manner, we investigated the potential effects of DRD1 (rs4531) and DRD2 (rs6277) receptor polymorphisms on this dimension...
  50. Lee S, Minowa M, Mouradian M. Two distinct promoters drive transcription of the human D1A dopamine receptor gene. J Biol Chem. 1996;271:25292-9 pubmed
    ..These data taken together indicate that the human D1A gene has two functional TATA-less promoters, both in D1A expressing cultured neuroblastoma cells and in the human striatum. ..
  51. Cho E, Choi S, Kim J, Kim J, Lee M, Chung B, et al. A Mutation in Plant-Specific SWI2/SNF2-Like Chromatin-Remodeling Proteins, DRD1 and DDM1, Delays Leaf Senescence in Arabidopsis thaliana. PLoS ONE. 2016;11:e0146826 pubmed publisher
    ..Therefore, we chose to examine the functions of DRD1, a SWI2/SNF2 chromatin remodeling protein, in epigenetic regulation of leaf senescence, particularly because drd1-6 ..
  52. de Moura A, Lazzari V, Becker R, Gil M, Ruthschilling C, Agnes G, et al. Gene expression in the CNS of lactating rats with different patterns of maternal behavior. Neurosci Res. 2015;99:8-15 pubmed publisher
    ..This study aimed to analyze the gene expression of the receptors for dopamine (Drd1a), prolactin (Prlr), serotonin (Htr1a, Htr1b), estrogen (Esr1, Esr2), and of Bdnf in the olfactory bulb (OB), ..
  53. Verhoeff N, Hussey D, Lee M, Tauscher J, Papatheodorou G, Wilson A, et al. Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humans. Mol Psychiatry. 2002;7:233, 322-8 pubmed
    ..Thus, while DA depletion "uncovers" D(2)receptors, it does not do so for D(1) receptors. The implications of this finding for measuring endogenous DA and its effects on in vivo receptor binding in humans are discussed. ..
  54. Yao J, Ding M, Pang H, Xing J, Xuan J, Wang B. Dopamine D1 receptor (DRD1) 5' region haplotypes significantly affect transcriptional activity in vitro. Neurosci Lett. 2015;609:120-3 pubmed publisher
    The role of dopamine D1 receptor (DRD1) gene promoter polymorphisms in schizophrenia remains controversial...
  55. Torvinen M, Gines S, Hillion J, Latini S, Canals M, Ciruela F, et al. Interactions among adenosine deaminase, adenosine A(1) receptors and dopamine D(1) receptors in stably cotransfected fibroblast cells and neurons. Neuroscience. 2002;113:709-19 pubmed
  56. Preuss U, Koller G, Samochowiec A, Zill P, Samochowiec J, Kucharska Mazur J, et al. Serotonin and Dopamine Candidate Gene Variants and Alcohol- and Non-Alcohol-Related Aggression. Alcohol Alcohol. 2015;50:690-9 pubmed publisher
    ..With findings from genome-wide association studies linking aggression-related traits to second messenger systems, further studies are needed to determine the genetic underpinnings of non-alcohol and alcohol-related aggression. ..
  57. Dolzan V, Plesnicar B, Serretti A, Mandelli L, Zalar B, Koprivsek J, et al. Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:809-15 pubmed
    ..the complex interaction between genetic and clinical factors, we studied the possible cross-interactions between DRD1 and DRD2 dopamine receptor gene polymorphisms, symptomatology of schizophrenia and schizoaffective disorders, and ..
  58. Wolski H, Marek P, Drews K, Barlik M, Kurzawińska G, Oarowski M, et al. DRD1 and DRD4 dopamine receptors in the etiology of preeclampsia. Ginekol Pol. 2015;86:672-7 pubmed
    ..The aim of the study was to evaluate the impact of the -48A>G DRD1 and -521C>T DRD4 polymorphisms in the etiology of PE among Polish women...
  59. Zhang H, Sun Z, Liu S, Yang L. Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis. Clin Interv Aging. 2016;11:17-27 pubmed publisher
    The role of GRK4 and DRD1 genes in hypertension remains controversial...
  60. Al Fulaij M, Ren Y, Beinborn M, Kopin A. Pharmacological analysis of human D1 AND D2 dopamine receptor missense variants. J Mol Neurosci. 2008;34:211-23 pubmed publisher
    ..The observation that the hD1R mutations induce significant alterations in pharmacologic properties may have implications both for disease susceptibility and/or therapeutic response to dopaminergic ligands. ..
  61. Lee K, Joo E, Ji Y, Kim D, Park J, Chung I, et al. Associations between DRDs and schizophrenia in a Korean population: multi-stage association analyses. Exp Mol Med. 2011;43:44-52 pubmed
    ..We investigated DRD1-5 for association with schizophrenia using a multi-stage approach in a Korean sample...
  62. Lee S, So C, Rashid A, Varghese G, Cheng R, Lança A, et al. Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal. J Biol Chem. 2004;279:35671-8 pubmed
  63. Fuenzalida J, Galaz P, Araya K, Slater P, Blanco E, Campusano J, et al. Dopamine D1 and corticotrophin-releasing hormone type-2? receptors assemble into functionally interacting complexes in living cells. Br J Pharmacol. 2014;171:5650-64 pubmed publisher
    ..We hypothesized that this observed synergism could be instrumented by heteromers containing the dopamine D1 receptor and CRF2 ? receptor...
  64. Grippo R, Purohit A, Zhang Q, Zweifel L, Guler A. Direct Midbrain Dopamine Input to the Suprachiasmatic Nucleus Accelerates Circadian Entrainment. Curr Biol. 2017;27:2465-2475.e3 pubmed publisher
    ..We demonstrate that D1 dopamine receptor (Drd1) signaling within the SCN is necessary for properly timed resynchronization of activity rhythms to phase-shifted ..
  65. Corrales E, Navarro A, Cuenca P, Campos D. Candidate gene study reveals DRD1 and DRD2 as putative interacting risk factors for youth depression. Psychiatry Res. 2016;244:71-7 pubmed publisher
    ..interaction effect was detected between rs1039089 in conjunction with rs877138 located upstream of the dopamine D1 receptor (DRD1) and the dopamine D2 receptor (DRD2) genes respectively, although no evidence was found for any ..
  66. Yasseen B, Kennedy J, Zawertailo L, Busto U. Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. Psychiatry Res. 2010;176:30-3 pubmed publisher
    ..RFLP analysis of single nucleotide polymorphisms were performed in dopamine (DRD1, DRD2 and DRD3) and serotonin receptor and transporter genes (5HTTLPR, 5HT1B, 5HT2A, 5HT2C)...
  67. Ribases M, Ramos Quiroga J, Hervas A, Sánchez Mora C, Bosch R, Bielsa A, et al. Candidate system analysis in ADHD: evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1. World J Biol Psychiatry. 2012;13:281-92 pubmed publisher
    ..on this information we evaluated the contribution to ADHD of nine genes involved in dopaminergic neurotransmission (DRD1, DRD2, DRD3, DRD4, DRD5, DAT1, TH, DBH and COMT)...
  68. Mahajan S, Aalinkeel R, Reynolds J, Nair B, Sykes D, Hu Z, et al. Therapeutic targeting of "DARPP-32": a key signaling molecule in the dopiminergic pathway for the treatment of opiate addiction. Int Rev Neurobiol. 2009;88:199-222 pubmed publisher
    ..These findings have the potential to facilitate the development of DARPP32 siRNA-based therapeutics against drug addiction. ..
  69. Holmes C, Smith H, Ganderton R, Arranz M, Collier D, Powell J, et al. Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation. J Neurol Neurosurg Psychiatry. 2001;71:777-9 pubmed
    This study investigated possible associations between selected polymorphisms in the dopamine receptor genes DRD1 and DRD3 with the presence of psychotic phenomena or aggressive behaviour in a community based cohort of 134 patients with ..
  70. Muñiz J, Prieto J, Gonzalez B, Sosa M, Cadet J, Scorza C, et al. Cocaine and Caffeine Effects on the Conditioned Place Preference Test: Concomitant Changes on Early Genes within the Mouse Prefrontal Cortex and Nucleus Accumbens. Front Behav Neurosci. 2017;11:200 pubmed publisher
    ..Gene expression analysis after CPP test revealed specific up-regulation in the CAF-COC group of Drd1a, cFos, and FosB in the NAc, and cFos, Egr1, and Npas4 in the mPFC...
  71. Sidharthan N, Minchin R, Butcher N. Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J Biol Chem. 2013;288:34364-74 pubmed publisher
    ..Taken together, these results show that dopamine can induce its own metabolism and protect neuron-like cells from damage, suggesting that SULT1A3 activity may be a risk factor for dopamine-dependent neurodegenerative diseases. ..
  72. Hazelwood L, Free R, Cabrera D, Skinbjerg M, Sibley D. Reciprocal modulation of function between the D1 and D2 dopamine receptors and the Na+,K+-ATPase. J Biol Chem. 2008;283:36441-53 pubmed publisher
    ..This evidence for reciprocal regulation between DARs and NKA provides a novel control mechanism for both DAR signaling and cellular ion balance. ..
  73. Maron E, Tõru I, Tasa G, Must A, Toover E, Lang A, et al. Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers. Neurosci Lett. 2008;446:88-92 pubmed publisher
    ..including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T-C, CCKR1 246G-A, CCKR2 -215C-A, DRD1 -94G-A and COMT Val158Met, were selected for genotyping based on previous positive findings from genetic ..
  74. Ferrari M, Comi C, Marino F, Magistrelli L, De Marchi F, Cantello R, et al. Polymorphisms of dopamine receptor genes and risk of visual hallucinations in Parkinson's patients. Eur J Clin Pharmacol. 2016;72:1335-1341 pubmed
    ..Polymerase chain reaction for SNPs in both D1-like (DRD1A-48G [rs4532] and C62T [rs686], DRD5T798C [rs6283]) and D2-like DR (DRD2G2137A [rs1800497] and C957T [rs6277], ..
  75. Rankin M, Marinec P, Cabrera D, Wang Z, Jose P, Sibley D. The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4. Mol Pharmacol. 2006;69:759-69 pubmed
    ..Furthermore, our data provide direct evidence that, in contrast to current dogma, GRKs can (at least in some instances) constitutively phosphorylate GPCRs in the absence of agonist activation resulting in constitutive desensitization. ..
  76. Sakolsky D, Ashby B. Patterns of cyclic AMP formation by coexpressed D1 and D2L dopamine receptors in HEK 293 cells. Receptors Channels. 2001;7:479-89 pubmed
    ..The model leads to a re-interpretation of the pharmacology of dopaminergic ligands. Hence, one consequence of colocalization is that D2 receptor antagonists become functional agonists of cAMP formation. ..
  77. Fung M, Rana B, Tang C, Shiina T, Nievergelt C, Rao F, et al. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. Kidney Int. 2009;76:1070-80 pubmed publisher
    Because dopamine D(1) receptors (DRD1) influence renal sodium transport and vascular hemodynamics, we examined whether genetic polymorphisms play a role in renal function...
  78. Paweł K, Hauser J, Skibinska M, Szczepankiewicz A, Dmitrzak Weglarz M, Gorzkowska K, et al. [Family based association study of DRD1, DRD2, DRD3, DRD4, DAT, COMT gene polymorphism in schizophrenia]. Psychiatr Pol. 2010;44:405-13 pubmed
    ..The genes under investigation were the following: DRD1 (polymorphism -48A/G), DRD2 (polymorphism -141C ins/del), DRD3 (polymorphism Ser9Gly), DRD4 (polymorphism -521C/T), ..
  79. Kollins S, Anastopoulos A, Lachiewicz A, Fitzgerald D, Morrissey Kane E, Garrett M, et al. SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1580-8 pubmed publisher
    ..Results also shed light on the molecular genetic basis of specific processes that may underlie the disorder. ..
  80. Błasiak E, Łukasiewicz S, Szafran Pilch K, Dziedzicka Wasylewska M. Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor. Pharmacol Rep. 2017;69:235-241 pubmed publisher
    ..dopamine receptors, polymorphic mutations in the D2 receptor play a role in dimmer formation with the dopamine D1 receptor. The association level of dopamine receptors is affected by ligand administration, with variable effects ..
  81. Lee F, Xue S, Pei L, Vukusic B, Chery N, Wang Y, et al. Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Cell. 2002;111:219-30 pubmed
    ..While one interaction is involved in the inhibition of NMDA receptor-gated currents, the other is implicated in the attenuation of NMDA receptor-mediated excitotoxicity through a PI-3 kinase-dependent pathway. ..
  82. Orun O, Nacar C, Cabadak H, Tiber P, Dogan Y, Guneysel O, et al. Investigation of the association between dopamine D1 receptor gene polymorphisms and essential hypertension in a group of Turkish subjects. Clin Exp Hypertens. 2011;33:418-21 pubmed publisher
    ..renal sodium excretion through direct interaction with the dopamine receptors, especially with the Dopamine D1 receptor (DRD1)...
  83. Ujike H. [Molecular genetics of alcohol dependence]. Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008;43:87-96 pubmed
    ..These unexpected new findings by gene-chip technology, which need to be confirmed by case-control association one by one, must bring about breakthrough in investigation of neural mechanisms of alcohol dependence and innovative therapy. ..
  84. Zhang C, Wu Z, Shao Y, Li Z, Yu S, Fang Y. [Association analysis between dopamine D1 receptor gene and symptom quantitative trait of schizophrenia]. Zhonghua Yi Xue Za Zhi. 2011;91:2019-22 pubmed
    To explore the relationship between dopamine D1 receptor gene (DRD1) and symptom quantitative trait of schizophrenia. Peripheral blood samples were collected from 211 schizophrenics and 247 healthy controls at our center...
  85. Baetu I, Burns N, Urry K, Barbante G, Pitcher J. Commonly-occurring polymorphisms in the COMT, DRD1 and DRD2 genes influence different aspects of motor sequence learning in humans. Neurobiol Learn Mem. 2015;125:176-88 pubmed publisher
    ..the catechol-O-methyltransferase (COMT) enzyme, the dopamine transporter (DAT) and dopamine D1 and D2 receptors (DRD1 and DRD2)...