DRAM1

Summary

Gene Symbol: DRAM1
Description: DNA damage regulated autophagy modulator 1
Alias: DRAM, DNA damage-regulated autophagy modulator protein 1, damage-regulated autophagy modulator
Species: human
Products:     DRAM1

Top Publications

  1. Crighton D, Wilkinson S, O Prey J, Syed N, Smith P, Harrison P, et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell. 2006;126:121-34 pubmed
    ..Here we describe DRAM (damage-regulated autophagy modulator), a p53 target gene encoding a lysosomal protein that induces macroautophagy, ..
  2. Crighton D, Wilkinson S, Ryan K. DRAM links autophagy to p53 and programmed cell death. Autophagy. 2007;3:72-4 pubmed
    ..The recent discovery, therefore, of DRAM (damage-regulated autophagy modulator) as a new p53 target which modulates autophagy is a major step forward in ..
  3. Zhang X, Qi L, Wu J, Qin Z. DRAM1 regulates autophagy flux through lysosomes. PLoS ONE. 2013;8:e63245 pubmed publisher
    ..inhibitor 3-nitropropionic acid (3-NP), induces the expression of DNA damage-regulated autophagy modulator1 (DRAM1) and activation of autophagy in rat striatum...
  4. Mah L, O Prey J, Baudot A, Hoekstra A, Ryan K. DRAM-1 encodes multiple isoforms that regulate autophagy. Autophagy. 2012;8:18-28 pubmed publisher
    ..p53 induces autophagy via transcriptional activation of Damage-Regulated Autophagy Modulator (DRAM-1)...
  5. Lorin S, Borges A, Ribeiro Dos Santos L, Souquere S, Pierron G, Ryan K, et al. c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. Cancer Res. 2009;69:6924-31 pubmed publisher
    ..Furthermore, we showed that 2-ME up-regulates damage-regulated autophagy modulator (DRAM), a p53 target gene, in Ewing sarcoma cells through a mechanism that involves JNK activation...
  6. Wang W, Chen G, Pan X, Zhang Y, Wang X, Bindschaedler V, et al. Leaky Cauldron on the Dark Land: Understanding Memory Side-Channel Hazards in SGX. Conf Comput Commun Secur. 2017;2017:2421-2434 pubmed publisher
    ..Our research identifies 8 potential attack vectors, ranging from TLB to DRAM modules...
  7. Shin H, Chung E. In-DRAM Cache Management for Low Latency and Low Power 3D-Stacked DRAMs. Micromachines (Basel). 2019;10: pubmed publisher
    Recently, 3D-stacked dynamic random access memory (DRAM) has become a promising solution for ultra-high capacity and high-bandwidth memory implementations...
  8. Zhu B, Wu X, Liu W, Ding S, Zhang D, Fan Z. Dielectric Enhancement of Atomic Layer-Deposited Al2O3/ZrO2/Al2O3 MIM Capacitors by Microwave Annealing. Nanoscale Res Lett. 2019;14:53 pubmed publisher
    For metal-insulator-metal (MIM) capacitors applicated in the fields of RF, DRAM, and analog/mixed-signal integrated circuits, a high capacitance density is imperative with the downscaling of the device feature size...
  9. Kim M, Ha J, Kwon I, Han J, Cho S, Cho I. A Novel One-Transistor Dynamic Random-Access Memory (1T DRAM) Featuring Partially Inserted Wide-Bandgap Double Barriers for High-Temperature Applications. Micromachines (Basel). 2018;9: pubmed publisher
    ..In this work, a novel one-transistor dynamic random-access memory (1T DRAM) featuring the device channel with partially inserted wide-bandgap semiconductor material toward the high-..

More Information

Publications60

  1. Benjamin D, Frawley H, Shields N, van de Water A, Taylor N. Relationship between diastasis of the rectus abdominis muscle (DRAM) and musculoskeletal dysfunctions, pain and quality of life: a systematic review. Physiotherapy. 2019;105:24-34 pubmed publisher
    Diastasis of the rectus abdominis muscle (DRAM) is common during and after pregnancy...
  2. Mrschtik M, O Prey J, Lao L, Long J, Beaumatin F, Strachan D, et al. DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose. Cell Death Differ. 2015;22:1714-26 pubmed publisher
    ..We report here the characterization of a novel autophagy regulator that we have termed DRAM-3 due to its significant homology to damage-regulated autophagy modulator (DRAM-1)...
  3. Kim T, Kim H, Kang Y, Yoon S, Lee J, Choi W, et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-10 pubmed publisher
    ..of this, it was found that PsA significantly increased the expression of damage-regulated autophagy modulator (DRAM), a p53-induced protein...
  4. Vialle E, de Oliveira Pinto B, Vialle L, Gomez J. Evaluation of psychosomatic distress and its influence in the outcomes of lumbar fusion procedures for degenerative disorders of the spine. Eur J Orthop Surg Traumatol. 2015;25 Suppl 1:S25-8 pubmed publisher
    ..60 were included in the study and underwent objective evaluation using the Distress Risk Assessment Method (DRAM) evaluation for depressive/distress symptoms, VAS and Oswestry scores pre- and postoperatively...
  5. Abtahi A, Brodke D, Lawrence B, Zhang C, Spiker W. Association between patient-reported measures of psychological distress and patient satisfaction scores after spine surgery. J Bone Joint Surg Am. 2015;97:824-8 pubmed publisher
    ..Any patient who completed both a patient satisfaction survey and a Distress and Risk Assessment Method (DRAM) questionnaire for the same clinical encounter was included in the study...
  6. Chen X, Zheng Y, Zhu M, Ren K, Wang Y, Li T, et al. Scandium doping brings speed improvement in Sb2Te alloy for phase change random access memory application. Sci Rep. 2018;8:6839 pubmed publisher
    ..To develop PCRAM materials with better properties, especially to draw closer to dynamic random access memory (DRAM), the key challenge is to research new high-speed phase change materials...
  7. Zhou Z, Mao H, Wang X, Sun T, Chang Q, Chen Y, et al. Transient and flexible polymer memristors utilizing full-solution processed polymer nanocomposites. Nanoscale. 2018;10:14824-14829 pubmed publisher
    ..The obtained device exhibits reversible resistive switching behavior and a dynamic random access memory (DRAM) storage feature, with the significant merits of a high ON/OFF ratio, low switching voltage, excellent ..
  8. Zhang Z, Wang Y, Luo Y, He Y, Ma M, Yang R, et al. Electrochemical metallization cell with anion supplying active electrode. Sci Rep. 2018;8:12617 pubmed publisher
    ..metallization (ECM) memories are among the various emerging non-volatile memory technologies, contending to replace DRAM and Flash and enabling novel neuromorphic computing applications...
  9. Pang L, Liu K, Liu D, Lv F, Zang Y, Xie F, et al. Differential effects of reticulophagy and mitophagy on nonalcoholic fatty liver disease. Cell Death Dis. 2018;9:90 pubmed publisher
    ..When treated with OA for 24 h, DRAM expression-dependent mitophagy resulted in increased apoptosis in HepG2 cells...
  10. Charles R, Douglas P, Hallin I, Matthews I, Liversage G. An investigation of trends in precious metal and copper content of RAM modules in WEEE: Implications for long term recycling potential. Waste Manag. 2017;60:505-520 pubmed publisher
    ..b>DRAM was found to be 'high grade' waste with: stable levels of gold and silver over time; 80% reduction in palladium ..
  11. Nelson G, Lines A, Casella A, Bello J, Bryan S. Development and testing of a novel micro-Raman probe and application of calibration method for the quantitative analysis of microfluidic nitric acid streams. Analyst. 2018;143:1188-1196 pubmed publisher
    ..Spectra recorded for each probe using the same static HNO3 solution set contained in 2 dram glass vials were used as training sets to produce models for the respective probes...
  12. Scherer M, Fell J, Thomas S, Voas R. Effects of Dram Shop, Responsible Beverage Service Training, and State Alcohol Control Laws on Underage Drinking Driver Fatal Crash Ratios. Traffic Inj Prev. 2015;16 Suppl 2:S59-65 pubmed publisher
    In this study, we aimed to determine whether three minimum legal drinking age 21 (MLDA-21) laws-dram shop liability, responsible beverage service (RBS) training, and state control of alcohol sales-have had an impact on underage drinking ..
  13. Mioka T, Fujimura Kamada K, Mizugaki N, Kishimoto T, Sano T, Nunome H, et al. Phospholipid flippases and Sfk1p, a novel regulator of phospholipid asymmetry, contribute to low permeability of the plasma membrane. Mol Biol Cell. 2018;: pubmed publisher
    ..We isolated Sfk1p, a conserved membrane protein in the TMEM150/FRAG1/DRAM family, as a multicopy suppressor of this sensitivity...
  14. Tatura R, Kraus T, Giese A, Arzberger T, Buchholz M, Höglinger G, et al. Parkinson's disease: SNCA-, PARK2-, and LRRK2- targeting microRNAs elevated in cingulate gyrus. Parkinsonism Relat Disord. 2016;33:115-121 pubmed publisher
    ..An additional 5 out of ten potential target genes tested were downregulated. These are DRAM (DNA damage regulated autophagy modulator 1), predicted to be regulated by miR-144, EVC (Ellis Van Creveld Protein) by miR-221, ZNF440 (Zinc ..
  15. Memmert S, Nogueira A, Damanaki A, Nokhbehsaim M, Eick S, Divnic Resnik T, et al. Damage-regulated autophagy modulator 1 in oral inflammation and infection. Clin Oral Investig. 2018;22:2933-2941 pubmed publisher
    ..This study sought to examine the presence and regulation of DRAM1 in periodontal diseases...
  16. van de Water A, Benjamin D. Measurement methods to assess diastasis of the rectus abdominis muscle (DRAM): A systematic review of their measurement properties and meta-analytic reliability generalisation. Man Ther. 2016;21:41-53 pubmed publisher
    Systematic literature review. Diastasis of the rectus abdominis muscle (DRAM) has been linked with low back pain, abdominal and pelvic dysfunction. Measurement is used to either screen or to monitor DRAM width...
  17. Werner L, Huang S, Francis D, Armstrong E, Ma F, Li C, et al. Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors. Mol Cancer Ther. 2015;14:1994-2003 pubmed publisher
    ..apoptosis were specifically modulated following the combined AMG 232/radiation treatment, including FoxM1, ULK-1, DRAM, and BAX...
  18. Li W, Liu H, Wang S, Chen S, Wang Q. The Optimization of Spacer Engineering for Capacitor-Less DRAM Based on the Dual-Gate Tunneling Transistor. Nanoscale Res Lett. 2018;13:73 pubmed publisher
    The DRAM based on the dual-gate tunneling FET (DGTFET) has the advantages of capacitor-less structure and high retention time...
  19. Larsson E, Wahlstrand B, Hedblad B, Hedner T, Kjeldsen S, Melander O, et al. Hypertension and genetic variation in endothelial-specific genes. PLoS ONE. 2013;8:e62035 pubmed publisher
    ..A common variant (rs10860812) in the DRAM (damage-regulated autophagy modulator) locus showed association with hypertension (P = 0...
  20. Fell J, Scherer M, Thomas S, Voas R. Assessing the Impact of Twenty Underage Drinking Laws. J Stud Alcohol Drugs. 2016;77:249-60 pubmed
    ..8%), fake identification support provisions for retailers (-11.9%), dram shop liability (-2.5%), and social host civil liability (-1.7%)...
  21. Huang T, Tsai C, Tateyama S, Kaneko T, Liou G. Highly transparent and flexible bio-based polyimide/TiO2 and ZrO2 hybrid films with tunable refractive index, Abbe number, and memory properties. Nanoscale. 2016;8:12793-802 pubmed publisher
    ..Therefore, memory devices derived from these PI hybrid films exhibited tunable memory properties from DRAM, SRAM, to WORM with a different TiO2 or ZrO2 content from 0 wt% to 50 wt% with a high ON/OFF ratio (10(8))...
  22. Zhang L, Xie D, Chen X, Hughes M, Jiang G, Lu Z, et al. p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells. Antimicrob Agents Chemother. 2016;60:5294-301 pubmed publisher
    ..expression levels of the target genes and proteins involved in autophagy and apoptosis, including LC3-II/I, p53, DRAM (damage-regulated autophagy modulator), PUMA (p53 upregulated modulator of apoptosis), Bax, p-AMPK (activated form ..
  23. Gao Z, Shan J, Wang B, Qiao L, Chen D, Zhang Y. DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner. Mol Neurobiol. 2018;55:1988-1997 pubmed publisher
    ..Damage-regulated autophagy modulator (DRAM) overexpression was also involved in NA-induced neuronal autophagy...
  24. Yang X, Xu X, Zhu J, Zhang S, Wu Y, Wu Y, et al. miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts. Oncotarget. 2016;7:79617-79628 pubmed publisher
    ..that treatment of CAFs with miR-31 mimic inhibited the expression of the autophagy-related genes Beclin-1, ATG, DRAM and LC3...
  25. Choi B, Joo J, Lee Y, Jang I, Park S, Park Y. Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell. BMC Complement Altern Med. 2017;17:277 pubmed publisher
    ..death in CSC was mediated by p53-induced apoptosis acompanied by expresson of damage-regulated autophagy modulator (DRAM). In CRC, decreased DRAM expression (p < 0...
  26. Romano E, Scherer M, Fell J, Taylor E. A comprehensive examination of U.S. laws enacted to reduce alcohol-related crashes among underage drivers. J Safety Res. 2015;55:213-21 pubmed publisher
    ..Policies such as those regulating the age of bartenders, sellers, or servers; social host civil liability laws; dram shop laws; internal possession of alcohol laws; and fake identification laws do not appear to have the same impact ..
  27. Wei G, Huang Y, Li F, Zeng F, Li Y, Deng R, et al. XingNaoJing, prescription of traditional Chinese medicine, prevents autophagy in experimental stroke by repressing p53-DRAM pathway. BMC Complement Altern Med. 2015;15:377 pubmed publisher
    ..of autophagy induced by serum-free condition and ischemia stroke in rats to further investigate whether the p53-DRAM pathway is involved in the effects of XNJ on autophagy...
  28. Guan J, Zhang X, Sun W, Qi L, Wu J, Qin Z. DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX. Cell Death Dis. 2015;6:e1624 pubmed publisher
    b>DRAM1 (DNA damage-regulated autophagy modulator 1) is a TP53 target gene that modulates autophagy and apoptosis. We previously found that DRAM1 increased autophagy flux by promoting lysosomal acidification and protease activation...
  29. Mommers E, Ponten J, Al Omar A, de Vries Reilingh T, Bouvy N, Nienhuijs S. The general surgeon's perspective of rectus diastasis. A systematic review of treatment options. Surg Endosc. 2017;31:4934-4949 pubmed publisher
    Diastasis of the rectus abdominis muscles (DRAM) is characterised by thinning and widening of the linea alba, combined with laxity of the ventral abdominal musculature...
  30. Laforge M, Limou S, Harper F, Casartelli N, Rodrigues V, Silvestre R, et al. DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV. PLoS Pathog. 2013;9:e1003328 pubmed publisher
    ..Herein, we demonstrate that HIV infection induces damage-regulated autophagy modulator (DRAM) expression in a p53-dependent manner...
  31. Humbert M, Mueller C, Fey M, Tschan M. Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells. Leuk Res. 2012;36:1552-6 pubmed publisher
    The damage-regulator autophagy modulator 1 (DRAM-1) is a lysosomal protein that positively regulates autophagy in a p53-dependent manner. We aimed at analyzing the role of DRAM-1 in granulocytic differentiation of APL cells...
  32. Park S, Kim K, Lee E, Kim B, Lee T, Seo T, et al. Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death. Biochem Biophys Res Commun. 2009;390:1340-4 pubmed publisher
    ..Damage-regulated autophagy regulator (DRAM) has been identified as an effector molecule that is critical for p53-mediated apoptosis, and we investigated ..
  33. Wang L, Zhu Z, Zhang X, Dong X, Wang Y. DOMe: A deduplication optimization method for the NewSQL database backups. PLoS ONE. 2017;12:e0185189 pubmed publisher
    ..A recent research pointed out that the future NewSQL server will have thousands of CPU cores, large DRAM and huge NVRAM...
  34. Kerley Hamilton J, Pike A, Hutchinson J, Freemantle S, Spinella M. The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins. Biochim Biophys Acta. 2007;1769:209-19 pubmed
    ..In previous work we identified by microarray analysis a candidate p53 target gene, FLJ11259/DRAM. In this report we have identified three uncharacterized human proteins with sequence homology to FLJ11259, ..
  35. Takahashi M, Kakudo Y, Takahashi S, Sakamoto Y, Kato S, Ishioka C. Overexpression of DRAM enhances p53-dependent apoptosis. Cancer Med. 2013;2:1-10 pubmed publisher
    ..We identified damage-regulated autophagy modulator (DRAM) as one of the genes that were more upregulated by S121F than wild-type p53...
  36. Liu D, Liu M, Wang W, Pang L, Wang Z, Yuan C, et al. Overexpression of apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) induces apoptosis by promoting the transcription of caspase3 and DRAM in hepatoma cells. Biochem Biophys Res Commun. 2018;498:453-457 pubmed publisher
    ..Our data further showed that the expression of two pro-apoptotic genes, caspase3 and DRAM, were involved in full-length AIFM1 infection-induced apoptosis, and full-length AIFM1 could also positively ..
  37. Green D, Chipuk J. p53 and metabolism: Inside the TIGAR. Cell. 2006;126:30-2 pubmed
    ..The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy. ..
  38. Yu S, Yang H, Wang R, Luan Z, Qian D. Evaluating architecture impact on system energy efficiency. PLoS ONE. 2017;12:e0188428 pubmed publisher
    ..subcomponent level such as Central Processing Unit (CPU) cores, uncore components and Dynamic Random-Access Memory (DRAM) through exploiting the power measurement ability exposed by RAPL...
  39. Hu Y, Lin C, Li W. Design of dynamic genetic memory. IET Syst Biol. 2017;11:182-189 pubmed publisher
    In electronic systems, dynamic random access memory (DRAM) is one of the core modules in the modern silicon computer...
  40. Yi H, Liang B, Jia J, Liang N, Xu H, Ju G, et al. Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells. FEBS Lett. 2013;587:436-43 pubmed publisher
    ..We also identify DRAM1 and Beclin1 as novel target genes for miR-199a-5p...
  41. O Prey J, Skommer J, Wilkinson S, Ryan K. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. Cell Cycle. 2009;8:2260-5 pubmed
    ..a number of new autophagy regulators have been defined, including the Damage-Regulated Autophagy Modulator (DRAM), which is a lysosomal protein that links autophagy and the tumor suppressor, p53...
  42. Valbuena A, Castro Obregón S, Lazo P. Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway. PLoS ONE. 2011;6:e17320 pubmed publisher
    ..We have identified that downregulation of VRK1 protein levels requires DRAM expression, a p53-induced gene. DRAM is located in the endosomal-lysosomal compartment...
  43. Garufi A, Pistritto G, Baldari S, Toietta G, Cirone M, D Orazi G. p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions. J Exp Clin Cancer Res. 2017;36:126 pubmed publisher
    ..Here we report that, in response to drug adriamycin (ADR) in HG, p53 efficiently induced the expression of DRAM (damage-regulated autophagy modulator), a p53 target gene and a stress-induced regulator of autophagy...
  44. Huang T, Cheng S, Tsai C, Liou G. Optically Isotropic, Colorless, and Flexible PITEs/TiO2 and ZrO2 Hybrid Films with Tunable Refractive Index, Abbe Number, and Memory Properties. Sci Rep. 2017;7:7978 pubmed publisher
    ..of memory prepared from these polymer films of hybrid showed interesting and adjustable memory behavior from DRAM, SRAM, to WORM at various titania or zirconia contents with a large ON/OFF ratio (108), denoting that ..
  45. van der Vaart M, Korbee C, Lamers G, Tengeler A, Hosseini R, Haks M, et al. The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected]. Cell Host Microbe. 2014;15:753-67 pubmed publisher
    ..and human macrophage models of mycobacterial infection reveals that the DNA damage-regulated autophagy modulator DRAM1 functions downstream of pathogen recognition by the Toll-like receptor (TLR)/interleukin-1 receptor (IL1R)-MYD88-..
  46. Ward M, Flemming N, Gallo L, Fotheringham A, McCarthy D, Zhuang A, et al. Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes. Sci Rep. 2017;7:15190 pubmed publisher
    ..Intervention therapies (i) vehicle (D); (ii) MitoQ (DMitoQ;0.6 mg/kg/day); (iii) Ramipril (DRam;3 mg/kg/day) or (iv) combination (DCoAd) were administered to male diabetic db/db mice for 12 weeks (nâ€..
  47. Li W, Liu H, Wang S, Chen S, Wang Q. The Programming Optimization of Capacitorless 1T DRAM Based on the Dual-Gate TFET. Nanoscale Res Lett. 2017;12:524 pubmed publisher
    ..the inherent disadvantages for the traditional one transistor (1T)-one capacitor (1C) dynamic random access memory (DRAM)...
  48. Clark R. Emerging Applications for High K Materials in VLSI Technology. Materials (Basel). 2014;7:2913-2944 pubmed publisher
    ..in Very Large Scale Integrated circuit (VLSI) manufacturing for leading edge Dynamic Random Access Memory (DRAM) and Complementary Metal Oxide Semiconductor (CMOS) applications is summarized along with the deposition methods ..
  49. Liu K, Shi Y, Guo X, Ouyang Y, Wang S, Liu D, et al. Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria. Cell Death Dis. 2014;5:e1078 pubmed publisher
    Increasing autophagy is beneficial for curing hepatocellular carcinoma (HCC). Damage-regulated autophagy modulator (DRAM) was recently reported to induce apoptosis by mediating autophagy...
  50. Kim S, Jung H, Lim C. Reactive oxygen species-dependent down-regulation of tumor suppressor genes PTEN, USP28, DRAM, TIGAR, and CYLD under oxidative stress. Biochem Genet. 2013;51:901-15 pubmed publisher
    ..and tensin homolog (PTEN), ubiquitin specific peptidase 28 (USP28), damage-regulated autophagy modulator (DRAM), TP53-induced glycolysis and apoptosis regulator (TIGAR), and cylindromatosis (CYLD)...
  51. Galavotti S, Bartesaghi S, Faccenda D, Shaked Rabi M, Sanzone S, McEvoy A, et al. The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Oncogene. 2013;32:699-712 pubmed publisher
    ..This autophagy signature included the autophagy-associated genes DRAM1 and SQSTM1, which encode a key regulator of selective autophagy, p62...