Gene Symbol: DPPA3
Description: developmental pluripotency associated 3
Alias: Pgc7, STELLA, developmental pluripotency-associated protein 3, stella-related protein
Species: human
Products:     DPPA3

Top Publications

  1. Sato M, Kimura T, Kurokawa K, Fujita Y, Abe K, Masuhara M, et al. Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells. Mech Dev. 2002;113:91-4 pubmed
    ..During the process, we cloned a novel gene, PGC7, which was preferentially expressed in PGCs...
  2. Payer B, Saitou M, Barton S, Thresher R, Dixon J, Zahn D, et al. Stella is a maternal effect gene required for normal early development in mice. Curr Biol. 2003;13:2110-7 pubmed
    b>stella is a novel gene specifically expressed in primordial germ cells, oocytes, preimplantation embryos, and pluripotent cells...
  3. Bortvin A, Goodheart M, Liao M, Page D. Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. BMC Dev Biol. 2004;4:2 pubmed
    ..The function of Dppa3 (also known as Pgc7 or stella), a gene expressed in primordial germ cells at the time of their emergence in gastrulating embryos, is unknown, ..
  4. Nakamura T, Arai Y, Umehara H, Masuhara M, Kimura T, Taniguchi H, et al. PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat Cell Biol. 2007;9:64-71 pubmed
    ..Here, we show that PGC7/Stella, a maternal factor essential for early development, protects the DNA methylation state of several imprinted loci ..
  5. Zuccotti M, Merico V, Redi C, Bellazzi R, Adjaye J, Garagna S. Role of Oct-4 during acquisition of developmental competence in mouse oocyte. Reprod Biomed Online. 2009;19 Suppl 3:57-62 pubmed
    ..summarizes the results of recent studies showing that the Oct-4 transcription factor regulating the expression of Stella and Foxj2 at the Nanog locus could play a pivotal role in the establishment of the oocyte's developmental ..
  6. Heggie V. Testing sex and gender in sports; reinventing, reimagining and reconstructing histories. Endeavour. 2010;34:157-63 pubmed publisher
    ..inaccurate information and false assertions about gender fraud, particularly in relation to the 'classic' cases of Stella Walsh and Heinrich/Hermann/Dora Ratjen...
  7. Zhang Y, Li P, Pang J, Wan Y, Zhang G, Fan Y, et al. Induction of goat bone marrow mesenchymal stem cells into putative male germ cells using mRNA for STRA8, BOULE and DAZL. Cytotechnology. 2019;71:563-572 pubmed publisher
    ..These cells expressed primordial germ cell specific genes STELLA, C-KIT and MVH, as well as premeiotic genes DAZL, BOULE, STRA8, PIWIL2 and RNF17...
  8. Luo Y, Xie L, Mohsin A, Ahmed W, Xu C, Peng Y, et al. Efficient generation of male germ-like cells derived during co-culturing of adipose-derived mesenchymal stem cells with Sertoli cells under retinoic acid and testosterone induction. Stem Cell Res Ther. 2019;10:91 pubmed publisher
    ..Moreover, the expression of male germ cell-related markers (Oct4, Stella, Ddx4, Dazl, PGP9...
  9. Nakamura I, Maegawa H, Tobe K, Uno S. Safety and Effectiveness of Ipragliflozin for Type 2 Diabetes in Japan: 12-Month Interim Results of the STELLA-LONG TERM Post-Marketing Surveillance Study. Adv Ther. 2019;36:923-949 pubmed publisher
    The present interim report of the STELLA-LONG TERM study aimed to examine the safety and effectiveness of ipragliflozin in real-word clinical practice in Japan using data up to 12 months...

More Information

Publications110 found, 100 shown here

  1. Segunda M, Bahamonde J, Munoz I, Sepulveda S, Cortez J, De los Reyes M, et al. Sertoli cell-mediated differentiation of bovine fetal mesenchymal stem cells into germ cell lineage using an in vitro co-culture system. Theriogenology. 2019;130:8-18 pubmed publisher
    ..with BM-MSC or AT-MSC was analyzed on the expression of pluripotent factors OCT4 and NANOG, GC genes FRAGILLIS, STELLA and VASA and male GC markers DAZL, PIWIL2, STRA8 and SCP3 at Day 14 of coculture...
  2. Eskandari N, Hassani Moghaddam M, Atlasi M, Amini Mahabadi J, Taherian A, Nikzad H. The combination of retinoic acid and estrogen can increase germ cells genes expression in mouse embryonic stem cells derived primordial germ cells. Biologicals. 2018;56:39-44 pubmed publisher
    ..acid with estrogen group-treated cells exhibited increased mRNA expression of Stra8, Fragilis, Sycp3, GDF9, and Stella compared to untreated controls...
  3. Silvestris E, Cafforio P, D Oronzo S, Felici C, Silvestris F, Loverro G. In vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization. Hum Reprod. 2018;33:464-473 pubmed publisher
    ..GDF-9 and SYCP3 as final, and developmental pluripotency-associated protein 3 (DPPA3) as primordial, germline markers were measured by droplet digital PCR...
  4. Kambayashi A, Dressman J. Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro-In Silico-In Vivo Approach: Case Examples-Dipyridamole, Prasugrel, and Nelfinavir. J Pharm Sci. 2019;108:584-591 pubmed publisher
    ..An in silico prediction model based on the STELLA software was designed and simulations were conducted to predict the oral pharmacokinetic profiles of the 3 drugs ..
  5. Li Y, Zhang Z, Chen J, Liu W, Lai W, Liu B, et al. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1. Nature. 2018;564:136-140 pubmed publisher
    ..Here we demonstrate the importance of Stella, a factor essential for female fertility5-7, in shaping the oocyte methylome in mice...
  6. El Behery E, El Naseery N, El Ghazali H, Elewa Y, Mahdy E, El Hady E, et al. The efficacy of chronic zinc oxide nanoparticles using on testicular damage in the streptozotocin-induced diabetic rat model. Acta Histochem. 2019;121:84-93 pubmed publisher
    ..anti-PCNA (proliferating cell marker), anti-ssDNA (apoptotic cell marker), anti-SOX9 (Sertoli cell marker), anti-Stella (spermatogonia marker), anti-STRA8 (preleptotene and early-leptotene spermatocytes marker), anti-DMC1 (leptotene ..
  7. Malendowicz L. 100th anniversary of the discovery of the human adrenal fetal zone by Stella Starkel and Lesław Węgrzynowski: how far have we come?. Folia Histochem Cytobiol. 2010;48:491-506 pubmed publisher
    Year 2010 marks a centennial anniversary of the description by Stella Starkel and Lesław Węgrzynowski, Polish students of the Faculty of Medicine, University of Lwów, the fetal zone of the human fetal adrenal gland...
  8. Borrelli C, Panieri G, Dahl T, Neufeld K. Novel biomineralization strategy in calcareous foraminifera. Sci Rep. 2018;8:10201 pubmed publisher
    ..g., Cassidulina neoteretis, Lobatula lobatula, Nonionella stella) did not reveal the presence of silicate grains in the shell of the specimens analyzed confirming this to be a ..
  9. Speakman C, Domke T, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten D, et al. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition. Stem Cells. 2014;32:2605-15 pubmed publisher
    ..However, the transition of naïve cells to primed pluripotency indicated by Rex1 (Zfp42), Nanog, Esrrb, and Dppa3 downregulation and Fgf5 upregulation remains unchanged...
  10. Saenz de Juano M, Billooye K, Smitz J, Anckaert E. The loss of imprinted DNA methylation in mouse blastocysts is inflicted to a similar extent by in vitro follicle culture and ovulation induction. Mol Hum Reprod. 2016;22:427-41 pubmed publisher
    ..1 (Dnmt1o), methyl-CpG binding domain protein 3 (MBD3) and developmental pluripotency-associated 3 (Dppa3) was performed by qPCR between in vivo and in vitro grown oocytes at the germinal vesicle and metaphase II (MII) ..
  11. Shaikh A, Bhartiya D, Kapoor S, Nimkar H. Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells. Stem Cell Res Ther. 2016;7:59 pubmed publisher
    ..the corresponding increase in BrdU uptake and upregulation of specific transcripts (Oct-4A, Oct-4, Sca-1, Nanog, Stella, Fragilis, Pcna). Cells that survived 5-FU formed colonies in vitro...
  12. Chen L, Tseng C, Tseng W. Development of a system dynamics model for polycyclic aromatic hydrocarbons and its application to assess the benefits of pollution reduction. Ecotoxicol Environ Saf. 2018;166:231-236 pubmed publisher
    ..DMT) model for polycyclic aromatic hydrocarbons (PAHs) was constructed using the system dynamics software STELLA to simulate the transmission and flow of PAHs in different media...
  13. Mills M, Thornewill J, Esterhay R. Future trends in the supply and demand for radiation oncology physicists. J Appl Clin Med Phys. 2010;11:3005 pubmed
    ..To that end, a Demand & Supply dynamic model was created using STELLA software...
  14. Cortez J, Bahamonde J, De los Reyes M, Palomino J, Torres C, Peralta O. In vitro differentiation of bovine bone marrow-derived mesenchymal stem cells into male germ cells by exposure to exogenous bioactive factors. Reprod Domest Anim. 2018;53:700-709 pubmed publisher
    ..bfMSC cultured under in vitro conditions expressed OCT4, NANOG and DAZL, but lacked expression of mRNA of VASA, STELLA, FRAGILIS, STRA8 and PIWIL2. Treatment with exogenous BMP4 and TGFβ1 induced a transient increase (p < ...
  15. Cook J, Zhang J, Norrie J, Blal B, Cheng Z. Seaweed Extract (Stella Maris®) Activates Innate Immune Responses in Arabidopsis thaliana and Protects Host against Bacterial Pathogens. Mar Drugs. 2018;16: pubmed publisher
    ..The stimulatory activities of the A.nodosum marine alga-derived extract (Stella Maris&reg;) were investigated in a broad range of immune assays...
  16. Leng L, Tan Y, Gong F, Hu L, Ouyang Q, Zhao Y, et al. Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency. Hum Reprod. 2015;30:737-48 pubmed publisher
    ..markers [PR domain containing 1, with ZNF domain (PRDM1, BLIMP1), developmental pluripotency-associated 3 (DPPA3, STELLA), deleted in azoospermia-like (DAZL), and VASA (DDX4)] in GFP-positive cells than in GFP-negative cells...
  17. Lai D, Xu M, Zhang Q, Chen Y, Li T, Wang Q, et al. Identification and characterization of epithelial cells derived from human ovarian follicular fluid. Stem Cell Res Ther. 2015;6:13 pubmed publisher
    ..vitro and expressed the following transcription markers: deleted in azoospermia-like (DAZL), developmental pluripotency associated protein 3 stella-related protein (STELLA), zona pellucida gene family C (ZPC), Syntaptonemal complex ..
  18. James K, Bhartiya D, Ganguly R, Kaushik A, Gala K, Singh P, et al. Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium. J Ovarian Res. 2018;11:83 pubmed publisher
    ..of treatment were observed on pluripotent (Oct4A, Sox2, Nanog), progenitors (Oct-4, Sca-1), primordial germ cells (Stella, Fragilis) and proliferation (Pcna) specific transcripts by qRT-PCR analysis...
  19. Udalov I. Cyst-forming amoebae of the genus Korotnevella (Amoebozoa: Dactylopodida), with description of two new species. Eur J Protistol. 2015;51:480-93 pubmed publisher
    ..b>stella (Schaeffer, 1926) Goodkov, 1988, K. limbata n. sp. and K. heteracantha n. sp.) of this genus...
  20. Bakhtari A, Ross P. DPPA3 prevents cytosine hydroxymethylation of the maternal pronucleus and is required for normal development in bovine embryos. Epigenetics. 2014;9:1271-9 pubmed publisher
    b>Dppa3 has been described in mice as an important maternal factor contributed by the oocyte that participates in protecting the maternal genome from oxidation of methylated cytosines (5mC) to hydroxymethylated cytosines (5hmC)...
  21. Xie L, Lin L, Tang Q, Li W, Huang T, Huo X, et al. Sertoli cell-mediated differentiation of male germ cell-like cells from human umbilical cord Wharton's jelly-derived mesenchymal stem cells in an in vitro co-culture system. Eur J Med Res. 2015;20:9 pubmed publisher
    ..confocal microscopy, and Western blot analyses revealed the expression of early germ cell markers STELLA and VASA and male germ cell-specific marker DAZL in differentiated HUMSCs, confirming the presence of cells with ..
  22. Farshchian M, Matin M, Armant O, Geerts D, Dastpak M, Nakhaei Rad S, et al. Suppression of dsRNA response genes and innate immunity following Oct4, Stella, and Nanos2 overexpression in mouse embryonic fibroblasts. Cytokine. 2018;106:1-11 pubmed publisher
    ..the reprogramming potential of germ cell- specific genes, we designed a polycistronic gene cassette expressing Stella, Oct4 and Nanos2 in a lentiviral-based vector...
  23. Bhartiya D, Hinduja I, Patel H, Bhilawadikar R. Making gametes from pluripotent stem cells--a promising role for very small embryonic-like stem cells. Reprod Biol Endocrinol. 2014;12:114 pubmed publisher
    ..epigenetic modifications of parentally imprinted genes loci like Igf2-H19 and KCNQ1p57, share several markers like Stella, Fragilis, Mvh, Dppa2, Dppa4, Sall4, Blimp1 and functional receptors...
  24. Hu X, Lu H, Cao S, Deng Y, Li Q, Wan Q, et al. Stem cells derived from human first-trimester umbilical cord have the potential to differentiate into oocyte-like cells in vitro. Int J Mol Med. 2015;35:1219-29 pubmed publisher
    ..maturation protein-1 (Blimp1), PR domain containing 14 (Prdm14), transcription factor AP-2 gamma (Tfap2C), VASA, STELLA, deleted in azoospermia-like (DAZL) and interferon-induced transmembrane protein 3 (IFITM3)...
  25. Davaine J, Quérat J, Kaladji A, Guyomarch B, Chaillou P, Costargent A, et al. Treatment of TASC C and D Femoropoliteal Lesions with Paclitaxel eluting Stents: 12 month Results of the STELLA-PTX Registry. Eur J Vasc Endovasc Surg. 2015;50:631-7 pubmed publisher
    ..It requires frequent re-interventions during the first year to maintain satisfactory clinical results. ..
  26. Hayama T, Yamaguchi T, Kato Itoh M, Hamanaka S, Kawarai M, Sanbo M, et al. Generation of mouse functional oocytes in rat by xeno-ectopic transplantation of primordial germ cells. Biol Reprod. 2014;91:89 pubmed publisher
    ..These tissues were histologically similar to the normal gonad and expressed the oocyte markers Vasa and Stella. In addition, mouse germinal vesicle-stage oocyte-like cells collected from ovary-like tissue in rats matured to ..
  27. Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, et al. Global DNA hypomethylation coupled to cellular transformation and metastatic ability. FEBS Lett. 2015;589:4053-60 pubmed publisher
    ..Here, we show that the enforced expression of Stella (also known as PGC7 and Dppa3) induced not only global DNA demethylation but also transformation of NIH3T3 cells...
  28. de Souza A, Pieri N, Roballo K, Bressan F, Casals J, Ambrosio C, et al. Dynamics of male canine germ cell development. PLoS ONE. 2018;13:e0193026 pubmed publisher
    ..Here, we elucidated the dynamics of the expression of pluripotent (POU5F1 and NANOG), germline (DDX4, DAZL and DPPA3), and epigenetic (5mC, 5hmC, H3K27me3 and H3K9me2) markers that are important for the development of male canine ..
  29. Nakatani T, Yamagata K, Kimura T, Oda M, Nakashima H, Hori M, et al. Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation. EMBO Rep. 2015;16:582-9 pubmed publisher
    In the mouse zygote, Stella/PGC7 protects 5-methylcytosine (5mC) of the maternal genome from Tet3-mediated oxidation to 5-hydroxymethylcytosine (5hmC)...
  30. Araújo P, Sousa S, Diniz V, Gomes P, da Silva J, Germano A. Evaluation of patients undergoing placement of zygomatic implants using sinus slot technique. Int J Implant Dent. 2016;2:2 pubmed
    This study aimed to evaluate patients undergoing placement of zygomatic implants by Stella and Warner's technique, considering the survival rate of conventional and zygomatic implants, and assess the health of the maxillary sinuses and ..
  31. Xu X, Smorag L, Nakamura T, Kimura T, Dressel R, Fitzner A, et al. Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting. Nat Commun. 2015;6:6008 pubmed publisher
    ..Here, we show that germ-cell marker Dppa3 is present only in lg-iPSCs and hg-iPSCs, and that induction with exogenous Dppa3 enhances reprogramming kinetics, ..
  32. Maestro S, Scardigli S, Brunori E, Calderoni S, Curzio O, Denoth F, et al. [Anorexia nervosa and hyperactivity in adolescence: psychiatric and internal medicine features]. Minerva Pediatr. 2014;66:237-48 pubmed
    ..of ANR (DSM-IV-TR) were consecutively enrolled in the Child and Adolescent Eating Disorders Unit of the IRCCS-Stella Maris and assessed by an extensive clinical protocol...
  33. Duggal G, Heindryckx B, Warrier S, Taelman J, Van der Jeught M, Deforce D, et al. Exogenous supplementation of Activin A enhances germ cell differentiation of human embryonic stem cells. Mol Hum Reprod. 2015;21:410-23 pubmed publisher
    ..ActA up-regulated early primordial germ cell (PGC) genes STELLA/DPPA3 (developmental pluripotency associated 3) and tyrosine kinase receptor cKIT in both ActA-derived and ..
  34. D Arcangelo M, Todaro M, Salvini J, Benfante A, Colorito M, D Incecco A, et al. Cancer Stem Cells Sensitivity Assay (STELLA) in Patients with Advanced Lung and Colorectal Cancer: A Feasibility Study. PLoS ONE. 2015;10:e0125037 pubmed publisher
    ..The approach used for the STELLA trial allowed isolation of cancer stem cells in a consistent proportion of patients...
  35. Chi D, Zeng Y, Xu M, Si L, Qu X, Liu H, et al. LC3-Dependent Autophagy in Pig 2-Cell Cloned Embryos Could Influence the Degradation of Maternal mRNA and the Regulation of Epigenetic Modification. Cell Reprogram. 2017;: pubmed publisher
    ..A markedly higher level of Bmp15, H1foo, and Dppa3 was shown in cloned embryos at 2-cell stage (p?<?0.05 or p?<?0...
  36. Ogawa H, Watanabe H, Fukuda A, Kono T. Deficiency of genomic reprogramming in trophoblast stem cells following nuclear transfer. Cell Reprogram. 2015;17:115-23 pubmed publisher
    ..These TS cloned two-cell embryos were expressed low level of Dappa3 (also known as PGC7/Stella), indicating that zygotic gene activation (ZGA) was disrupted in these embryos...
  37. Aljayyoussi G, Kay K, Ward S, Biagini G. OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens. Malar J. 2016;15:344 pubmed publisher
    ..An internet-based tool has been developed using STELLA(®) software...
  38. Joo J, Choi H, Kim M, Zaehres H, Tapia N, Stehling M, et al. Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions. Sci Rep. 2014;4:7477 pubmed publisher
    ..of epiblast markers, such as Cer1, Eomes, Fgf5, Sox17, and T, and further showed complete DNA methylation of Stella and Dppa5 promoters...
  39. Farshchian M, Matin M, Bahrami M, Geerts D, Dastpak M, Shahriyari M, et al. Pluripotency induction in HEK293T cells by concurrent expression of STELLA, OCT4 and NANOS2. Biochem Biophys Res Commun. 2016;480:635-640 pubmed publisher
    ..In this study, we over-expressed 3 GSC-specific markers, STELLA, OCT4 and NANOS2, collectively designated as (SON), using the novel polycistronic lentiviral gene construct FUM-FD,..
  40. Bochkov A, OConnor B, Skoracki M. New Species and New Records of Mites of the Family Myocoptidae (Acariformes: Sarcoptoidea) From African Rodents. J Med Entomol. 2017;54:587-596 pubmed publisher
    ..from Hylomyscus anselli Bishop, 1979 (Rodentia: Muridae) from Tanzania (type host and locality) and Hylomyscus stella (Thomas, 1911) from Gabon, and Trichoecius faini sp. nov...
  41. Hua J, Pan S, Yang C, Dong W, Dou Z, Sidhu K. Derivation of male germ cell-like lineage from human fetal bone marrow stem cells. Reprod Biomed Online. 2009;19:99-105 pubmed
    ..These cells expressed early germ cell markers OCT4, STELLA, NANOG and VASA, and male germ-ceil-specific markers such as DAZL, TH2, c-kit, beta(1)-integrin, ACR, PRMl, FSHR, ..
  42. Sotelo K, Hamid N, Oey I, Gutierrez Maddox N, Ma Q, Leong S. Effect of pulsed electric fields on the flavour profile of red-fleshed sweet cherries (Prunus avium var. Stella). Molecules. 2015;20:5223-38 pubmed publisher
    ..effect of pulsed electric fields (PEF) on the flavour profile of red-fleshed sweet cherries (Prunus avium variety Stella)...
  43. Scaldaferri M, Klinger F, Farini D, Di Carlo A, Carsetti R, Giorda E, et al. Hematopoietic activity in putative mouse primordial germ cell populations. Mech Dev. 2015;136:53-63 pubmed publisher
    ..we identified various OCT3/4 positive populations showing distinct expression of PGC markers (BLIMP-1, AP, TG-1, STELLA) and co-expressing several proteins (CD-34, CD-41, FLK-1) and genes (Brachyury, Hox-B4, Scl/Tal-1 and Gata-2) of ..
  44. Kurkure P, Prasad M, Dhamankar V, Bakshi G. Very small embryonic-like stem cells (VSELs) detected in azoospermic testicular biopsies of adult survivors of childhood cancer. Reprod Biol Endocrinol. 2015;13:122 pubmed publisher
    ..studies on testicular smears showed that the VSELs were CD133+/CD45-/LIN-, expressed nuclear OCT-4, STELLA and cell surface SSEA-4...
  45. Ghasemi Hamidabadi H, Sobhani A, Nazm Bojnordi M. Multipotent SSEA1 Positive Cells Population Differentiation into Primordial Germ Cells and Subsequently Progress into Oocyte-like Cells. Arch Iran Med. 2015;18:404-10 pubmed publisher
    ..SSEA1 positive cells expressed Oct4, Stella, Mvh, c-kit, Scp3, Desmin, GFAP and Albumin. Interestingly, SSEA1 negative cells expressed Desmin and GFAP...
  46. Olesen N, Westh P, Holm R. Displacement of Drugs From Cyclodextrin Complexes by Bile Salts: A Suggestion of an Intestinal Drug-Solubilizing Capacity From an In Vitro Model. J Pharm Sci. 2016;105:2640-2647 pubmed publisher
    ..cyclodextrin formulation requires sufficient amount of cyclodextrins to fully solubilize the drug, as described by Stella's cyclodextrin utility number (UCD)...
  47. Mikedis M, Downs K. PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula. Dev Dyn. 2017;246:50-71 pubmed publisher
    ..While PRDM1 and STELLA colocalized predominantly within the hindgut, where putative PGCs reside, other colocalizing cells were found in ..
  48. Wen Y, He W, Jiang M, Zeng M, Cai L. Deriving cells expressing markers of female germ cells from premature ovarian failure patient-specific induced pluripotent stem cells. Regen Med. 2017;12:143-152 pubmed publisher
    ..Expression of markers of different stages of FGCs were detected. c-KIT, STELLA/DPPA3, VASA/DDX4, SCP3, GDF9 and ZP3 were positively detected and statistically significant different when ..
  49. Ye H, Li X, Zheng T, Hu C, Pan Z, Huang J, et al. The Hippo Signaling Pathway Regulates Ovarian Function via the Proliferation of Ovarian Germline Stem Cells. Cell Physiol Biochem. 2017;41:1051-1062 pubmed publisher
    ..separation were used to isolate and identify OGSCs by determining the expression of Mvh, Oct4, Nanog, Fragilis and Stella markers...
  50. Huang Y, Kim J, Do D, Lee C, Penfold C, Zylicz J, et al. Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition. elife. 2017;6: pubmed publisher
    ..We investigated the function of the maternally inherited factor Stella (encoded by Dppa3) using single-cell/embryo approaches...
  51. Rahjouei A, Pirouz M, Di Virgilio M, Kamin D, Kessel M. MAD2L2 Promotes Open Chromatin in Embryonic Stem Cells and Derepresses the Dppa3 Locus. Stem Cell Reports. 2017;8:813-821 pubmed publisher
    ..Among the most strongly suppressed genes was Dppa3, an ESC- and germ-cell-specific gene regulating DNA methylation...
  52. Han L, Ren C, Li L, Li X, Ge J, Wang H, et al. Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes. Nat Genet. 2018;50:432-442 pubmed publisher
    ..In a high-fat diet (HFD)-based female mouse model of obesity, we identified a marked reduction of Stella (also known as DPPA3 or PGC7) protein in oocytes...
  53. Rosa P, Wei N, Xu Z. Contribution to the genus Omalus Panzer, 1801 of China, with descriptions of two new species (Hymenoptera, Chrysididae). Zootaxa. 2015;4013:67-76 pubmed publisher
    ..hainanensis Rosa, Wei & Xu, sp. nov. (China, Hainan); the other two are newly recorded from China, O. stella (Semenov & Nikol'skaya, 1954) and O. timidus (Nurse, 1902), comb. nov...
  54. Semwanga A, Nakubulwa S, Adam T. Applying a system dynamics modelling approach to explore policy options for improving neonatal health in Uganda. Health Res Policy Syst. 2016;14:35 pubmed publisher
    ..completed the last three stages of DSM, which involved the development of a quantitative (simulation) model, using STELLA modelling software. We used statistical data to populate the model...
  55. Leong S, Burritt D, Hocquel A, Penberthy A, Oey I. The relationship between the anthocyanin and vitamin C contents of red-fleshed sweet cherries and the ability of fruit digests to reduce hydrogen peroxide-induced oxidative stress in Caco-2 cells. Food Chem. 2017;227:404-412 pubmed publisher
    ..work investigated the bioprotective capacities of red-fleshed sweet cherry cultivars (Prunus avium; Lapins, Stella, Sweetheart and Staccato), with distinct differences in anthocyanins and vitamin C contents, on human intestinal ..
  56. Vent P, Kaladji A, Davaine J, Guyomarch B, Chaillou P, Costargent A, et al. Bare Metal Versus Paclitaxel-Eluting Stents for Long Femoropopliteal Lesions: Prospective Cohorts Comparison Using a Propensity Score-Matched Analysis. Ann Vasc Surg. 2017;43:166-175 pubmed publisher
    ..In total, 110 limbs were treated (STELLA: n = 62; STELLA PTX: n = 48). We noted some difference between both cohorts regarding type 2 diabetes (P = 0...
  57. Leopardo N, Vitullo A. Early embryonic development and spatiotemporal localization of mammalian primordial germ cell-associated proteins in the basal rodent Lagostomus maximus. Sci Rep. 2017;7:594 pubmed publisher
    ..In the neural plate stage, a reduced 8 to 12 OCT4-positive cell population transiently expresses FRAGILIS, STELLA and SOX17 in the posterior streak...
  58. Rubbens J, Riethorst D, Brouwers J, Wolfs K, Adams E, Tack J, et al. Gastric and Duodenal Ethanol Concentrations after Intake of Alcoholic Beverages in Postprandial Conditions. Mol Pharm. 2017;14:4202-4208 pubmed publisher
    ..Volunteers subsequently consumed two standard units of beer (Stella Artois, 500 mL, 5...
  59. Sotelo K, Hamid N, Oey I, Pook C, Gutierrez Maddox N, Ma Q, et al. Red cherries (Prunus avium var. Stella) processed by pulsed electric field - Physical, chemical and microbiological analyses. Food Chem. 2018;240:926-934 pubmed publisher
    ..In conclusion, sweet cherries were only influenced by storage after PEF processing. PEF processing did not affect the growth of probiotic bacteria. ..
  60. Ip P. Benign endometrial proliferations mimicking malignancies: a review of problematic entities in small biopsy specimens. Virchows Arch. 2018;472:907-917 pubmed publisher
    ..The latter has been proposed as a precursor of endometrial mucinous carcinoma. Misinterpreting the Arias-Stella reaction as a malignant or premalignant lesion is more likely to occur if the pathologist is unaware that the ..
  61. Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Nakano T. Inhibition of maintenance DNA methylation by Stella. Biochem Biophys Res Commun. 2014;453:455-60 pubmed publisher
    ..We found that the enforced expression of Stella (also known as PGC7, Dppa3), a maternal factor required for the maintenance of DNA methylation in early embryos, ..
  62. Zhang C, Wu J. Production of offspring from a germline stem cell line derived from prepubertal ovaries of germline reporter mice. Mol Hum Reprod. 2016;22:457-64 pubmed publisher
    ..cell line, such as Ddx4, Deleted in azoospermia-like (Dazl), B lymphocyte-induced maturation protein-1 (Blimp1), Stella and Fragilis, was detected...
  63. Wasielak M, Wiesak T, Bogacka I, Jalali B, Bogacki M. Zygote arrest 1, nucleoplasmin 2, and developmentally associated protein 3 mRNA profiles throughout porcine embryo development in vitro. Theriogenology. 2016;86:2254-2262 pubmed publisher
    ..the MEGs, zygote arrest 1 (ZAR-1), nucleoplasmin 2 (NPM2), and developmentally associated pluripotency protein 3 (DPPA3), in porcine oocytes and embryos produced in vitro and in vivo...
  64. Dong G, Shang Z, Liu L, Liu C, Ge Y, Wang Q, et al. Retinoic acid combined with spermatogonial stem cell conditions facilitate the generation of mouse germ-like cells. Biosci Rep. 2017;37: pubmed publisher
    ..as shown by the activation of spermatogenesis-associated genes such as Mvh, Dazl, Prdm14, Stella, Scp1, Scp3, Stra8 and Rec8 In contrast, for cells cultured in control medium, the ..
  65. Wolfe A, Rodriguez A, Downs K. STELLA collaborates in distinct mesendodermal cell subpopulations at the fetal-placental interface in the mouse gastrula. Dev Biol. 2017;425:44-57 pubmed publisher
    ..Results of recent studies in the mouse have reported that STELLA (DPPA-3, PGC7) co-localizes with PRDM1 (BLIMP1), the bimolecular signature of putative primordial germ cells (PGCs)..
  66. Nyabadza F, Coetzee L. A Systems Dynamic Model for Drug Abuse and Drug-Related Crime in the Western Cape Province of South Africa. Comput Math Methods Med. 2017;2017:4074197 pubmed publisher
    ..The dynamics of drug abuse and drug-related crimes within the Western Cape are simulated using STELLA software...
  67. Uribe Etxebarria V, Luzuriaga J, García Gallastegui P, Agliano A, Unda F, Ibarretxe G. Notch/Wnt cross-signalling regulates stemness of dental pulp stem cells through expression of neural crest and core pluripotency factors. Eur Cell Mater. 2017;34:249-270 pubmed publisher
    ..with core transcriptional factors associated with stem cell pluripotency, such as Oct4a, Sox2, c-Myc, Rex1, Stella/Dppa3, Ssea1/Fut4, Lin28 and Nanog...
  68. Clark A, Rodriguez R, Bodnar M, Abeyta M, Cedars M, Turek P, et al. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. Stem Cells. 2004;22:169-79 pubmed
    ..The genes we identified in the current study include the human stella-related (STELLAR) gene, which encodes a highly divergent protein (with just 32...
  69. Julaton V, Reijo Pera R. NANOS3 function in human germ cell development. Hum Mol Genet. 2011;20:2238-50 pubmed publisher
    ..Findings may contribute to our understanding of the basic biology of human germ cell development and may provide clinical insights regarding infertility. ..
  70. Wongtrakoongate P, Jones M, Gokhale P, Andrews P. STELLA facilitates differentiation of germ cell and endodermal lineages of human embryonic stem cells. PLoS ONE. 2013;8:e56893 pubmed publisher
    b>Stella is a developmentally regulated gene highly expressed in mouse embryonic stem (ES) cells and in primordial germ cells (PGCs)...
  71. Matsunuma M, Motomura H. Chelidoperca stella, a new species of perchlet (Perciformes: Serranidae) from the Andaman Sea, eastern Indian Ocean. Zootaxa. 2016;4092:388-400 pubmed publisher
    A new species of serranid fish, Chelidoperca stella, is described on the basis of five specimens from the Andaman Sea in the eastern Indian Ocean...
  72. Kambayashi A, Dressman J. Forecasting gastrointestinal precipitation and oral pharmacokinetics of dantrolene in dogs using an in vitro precipitation testing coupled with in silico modeling and simulation. Eur J Pharm Biopharm. 2017;119:107-113 pubmed publisher
    ..The in silico prediction tool was designed using STELLA software and the predicted plasma concentration profiles of dantrolene using the in vitro precipitation data were ..
  73. Nakamura I, Maegawa H, Tobe K, Tabuchi H, Uno S. Safety and efficacy of ipragliflozin in Japanese patients with type 2 diabetes in real-world clinical practice: Interim results of the STELLA-LONG TERM post-marketing surveillance study. Expert Opin Pharmacother. 2017;: pubmed publisher
    ..The STELLA-LONG TERM study is an ongoing 3-year post-marketing surveillance study of ipragliflozin in type 2 diabetes (T2D) ..
  74. Ehrenpreis E, Smith D. Patients with newly diagnosed cervical cancer should be screened for anal human papilloma virus and anal dysplasia: Results of a pilot study using a STELLA computer simulation and economic model. Papillomavirus Res. 2018;5:38-45 pubmed publisher
    ..However, effectiveness of anal HPV screening is unknown. A dynamic model was constructed using STELLA. Populations are represented as "stocks" that change according to model rates...
  75. Bowles J, Teasdale R, James K, Koopman P. Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. Cytogenet Genome Res. 2003;101:261-5 pubmed
    ..11M2 corresponds to a recently reported gene variously known as PGC7, STELLA or DPPA3...
  76. Elliman S, Wu I, Kemp D. Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. J Biol Chem. 2006;281:16-9 pubmed
    ..Nanog, Oct4, and Dppa3 (Stella/PGC7) presented as source genes for >30 processed pseudogenes within the human genome...
  77. Waghray A, Saiz N, Jayaprakash A, Freire A, Papatsenko D, Pereira C, et al. Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm. Stem Cell Reports. 2015;5:97-110 pubmed publisher
    ..In-depth transcriptome analysis of this mESC state reveals Dppa3 as a direct downstream target of Tbx3...
  78. Xie F, Anderson C, Timme K, Kurz S, Fernando S, Wood J. Obesity-Dependent Increases in Oocyte mRNAs Are Associated With Increases in Proinflammatory Signaling and Gut Microbial Abundance of Lachnospiraceae in Female Mice. Endocrinology. 2016;157:1630-43 pubmed publisher
    ..The abundance of oocyte-specific Bnc1, Dppa3, and Pou5f1 mRNAs as well as markers of proinflammatory signaling were significantly increased in ovaries of obese ..
  79. Rubbens J, Brouwers J, Wolfs K, Adams E, Tack J, Augustijns P. Ethanol concentrations in the human gastrointestinal tract after intake of alcoholic beverages. Eur J Pharm Sci. 2016;86:91-5 pubmed publisher
    ..were asked to drink two standard consumptions of commercially available alcoholic beverages, including beer (Stella Artois®, 500 mL, 5...
  80. Mercier A, Sun Z, Parrish C, Hamel J. Remarkable Shifts in Offspring Provisioning during Gestation in a Live-Bearing Cnidarian. PLoS ONE. 2016;11:e0154051 pubmed publisher
    ..Here we studied the brooding sea anemone Aulactinia stella, using behavioural, morphological and biochemical indicators of offspring phenotype to characterize gestation and ..
  81. Blinka S, Reimer M, Pulakanti K, Rao S. Super-Enhancers at the Nanog Locus Differentially Regulate Neighboring Pluripotency-Associated Genes. Cell Rep. 2016;17:19-28 pubmed publisher
    ..One distal super-enhancer 45 kb upstream of Nanog (-45 enhancer) regulates both nearest neighbor genes, Nanog and Dppa3. Interestingly, eRNAs produced at the -45 enhancer specifically regulate Dppa3 expression by stabilizing looping ..
  82. Framenau V, Baehr B. Revision of the Australian Union-Jack wolf spiders, genus <i>Tasmanicosa</i> (Araneae, Lycosidae, Lycosinae). Zootaxa. 2016;4213:zootaxa.4213.1.1 pubmed publisher
    ..nov.); T. ramosa (L. Koch, 1877), comb. nov.; T. salmo sp. nov.; T. semicincta (L. Koch, 1877) comb. nov.; T. stella sp. nov.; and T. subrufa (Karsch, 1878) comb. nov...
  83. Shin S, Vogt E, Jimenez Movilla M, Baibakov B, Dean J. Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017;8:1643 pubmed publisher
    ..DPPA3/Stella/PGC7, encoded by a maternal effect gene, is present in the nucleus and cytoplasm of zygotes and has been ..
  84. Gerovska D, Araúzo Bravo M. Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?. Mol Hum Reprod. 2016;22:208-25 pubmed publisher
    ..primitive endoderm (PE)-epiblast (EPI) lineage specification? A burst of expression of PGC markers, such as Dppa3/Stella, Ifitm2/Fragilis, Fkbp6 and Prdm4, is observed from embryonic day (E) 3...
  85. Hosseini S, Moulavi F, Tanhaie Vash N, Asgari V, Ghanaei H, Abedi Dorche M, et al. The Principal Forces of Oocyte Polarity Are Evolutionary Conserved but May Not Affect the Contribution of the First Two Blastomeres to the Blastocyst Development in Mammals. PLoS ONE. 2016;11:e0148382 pubmed publisher
    ..examples of maternal mRNA localized to subcellular substructures S (NPM2, GMNN, H19, PCAF, DNMT3A, DNMT1, and STELLA), NS (SOX2, NANOG, POU5F1, and TET1), and FS (GCN) of MII oocyte...
  86. Díaz Feijoo B, Correa Paris A, Pérez Benavente A, Franco Camps S, Sanchez Iglesias J, Cabrera S, et al. Prospective Randomized Trial Comparing Transperitoneal Versus Extraperitoneal Laparoscopic Aortic Lymphadenectomy for Surgical Staging of Endometrial and Ovarian Cancer: The STELLA Trial. Ann Surg Oncol. 2016;23:2966-74 pubmed publisher
    ..A prospective randomized trial (STELLA trial) was designed to compare the perioperative outcomes and node retrieval of extraperitoneal versus ..
  87. Li P, Yan G, Han L, Pang J, Zhong B, Zhang G, et al. Overexpression of STRA8, BOULE, and DAZL Genes Promotes Goat Bone Marrow-Derived Mesenchymal Stem Cells In Vitro Transdifferentiation Toward Putative Male Germ Cells. Reprod Sci. 2017;24:300-312 pubmed publisher
    ..into early goat germ cell-like cells and that these cells expressed primordial germ cell specification genes STELLA (also known as DPPA3, developmental pluripotency associated 3) and C-KIT (tyrosine kinase receptor) as well as ..
  88. Wasielak M, Wiesak T, Bogacka I, Jalali B, Bogacki M. Maternal effect gene expression in porcine metaphase II oocytes and embryos in vitro: effect of epidermal growth factor, interleukin-1? and leukemia inhibitory factor. Zygote. 2017;25:120-130 pubmed publisher
    ..or LIF (leukemia inhibitory factor) affects the mRNA level of ZAR-1 (zygote arrest 1), NPM2 (nucleoplasmin 2) and DPPA3 (developmental associated protein 3) in porcine MII oocytes and embryos...
  89. Ruff A, Fiolka T, Kostewicz E. Prediction of Ketoconazole absorption using an updated in vitro transfer model coupled to physiologically based pharmacokinetic modelling. Eur J Pharm Sci. 2017;100:42-55 pubmed publisher
    ..these experiments for Ketoconazole (KTZ) were coupled to physiologically based pharmacokinetic (PBPK) model using Stella® software, which also incorporated the disposition kinetics of KTZ taken from the literature, in order to ..
  90. Kaladji A, Vent P, Danvin A, Chaillou P, Costargent A, Guyomarch B, et al. Impact of Vascular Calcifications on Long Femoropopliteal Stenting Outcomes. Ann Vasc Surg. 2018;47:170-178 pubmed publisher
    ..Patients belonging to 2 previously published registries (STELLA and STELLA PTX) and who underwent a preoperative CT scan were retrospectively included in the study...
  91. Palm S, Bäck T, Lindegren S, Hultborn R, Jacobsson L, Albertsson P. Model of Intraperitoneal Targeted α-Particle Therapy Shows That Posttherapy Cold-Antibody Boost Enhances Microtumor Radiation Dose and Treatable Tumor Sizes. J Nucl Med. 2018;59:646-651 pubmed publisher
    ..This finding should also hold for other high-affinity mAbs and short-lived α-emitters. ..
  92. Kawaguchi T, Tsukiyama T, Kimura K, Matsuyama S, Minami N, Yamada M, et al. Generation of Naïve Bovine Induced Pluripotent Stem Cells Using PiggyBac Transposition of Doxycycline-Inducible Transcription Factors. PLoS ONE. 2015;10:e0135403 pubmed publisher
    ..of biPSCs had strong alkaline phosphatase activity, expressed pluripotent markers (OCT3/4, NANOG, REX1, ESRRβ, STELLA, and SOCS3), and formed embryoid bodies that gave rise to differentiated cells from all three embryonic germ ..