DPF2

Summary

Gene Symbol: DPF2
Description: double PHD fingers 2
Alias: REQ, UBID4, ubi-d4, zinc finger protein ubi-d4, BAF45D, BRG1-associated factor 45D, D4, zinc and double PHD fingers family 2, apoptosis response zinc finger protein, protein requiem, requiem, apoptosis response zinc finger
Species: human
Products:     DPF2

Top Publications

  1. Pedersen T, Meuli J, Plazikowski E, Buttenberg M, Kleine Brueggeney M, Seidl C, et al. Loss of resistance: A randomised controlled trial assessing four low-fidelity epidural puncture simulators. Eur J Anaesthesiol. 2017;34:602-608 pubmed publisher
    ..Given the relative cost of a banana compared with a dedicated simulator, we suggest that a banana be used to teach the technique of LOR for epidural puncture. KEK Nr: Req-2015-z087.
  2. Sehnal L, Procházková T, Smutná M, Kohoutek J, Lepšová Skácelová O, Hilscherova K. Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species. Water Res. 2019;156:136-147 pubmed publisher
    ..water samples from 8 out of 17 localities with a maximal activity of 263 ng all-trans retinoic acid equivalent (REQ)/L...
  3. Almora Díaz C, Ramírez Solís A, Bunge C. Symmetric dissociation of the water molecule with truncation energy error. A benchmark study. Phys Chem Chem Phys. 2019;21:4953-4964 pubmed publisher
    ..The calculations comprise CISDTQ (CI-4x) through CI-8x for H2O at its equilibrium geometry (Req) and up to fifteen times Req. With the Dunning basis our SCI-TEE-8x energies differ from full CI by less than 0...
  4. Nakano M, Okada K, Nagami T, Tonami T, Kishi R, Kitagawa Y. Monte Carlo Wavefunction Approach to Singlet Fission Dynamics of Molecular Aggregates. Molecules. 2019;24: pubmed publisher
    ..03 fs) and a sufficiently large MC (~10⁵). The computational time (treq) in the MCWF approach also exhibits dramatic reduction with increasing the size of aggregates (N-mers) ..
  5. Shimazu A, Sonnentag S, Kubota K, Kawakami N. Validation of the Japanese version of the recovery experience questionnaire. J Occup Health. 2012;54:196-205 pubmed
    The aim of this study was to validate the Japanese version of the Recovery Experience Questionnaire (REQ-J), which assesses how individuals unwind and recuperate from work during leisure time (i.e...
  6. Zhang W, Chronis C, Chen X, Zhang H, Spalinskas R, Pardo M, et al. The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. Cell Stem Cell. 2019;24:138-152.e8 pubmed publisher
    ..Here we show that the Baf45 subunit Dpf2 maintains pluripotency and ESC differentiation potential...
  7. Cavar S, Vidic D, Maksimovic M. Volatile constituents, phenolic compounds, and antioxidant activity of Calamintha glandulosa (Req.) Bentham. J Sci Food Agric. 2013;93:1758-64 pubmed publisher
    Calamintha glandulosa (Req.) Bentham is an aromatic perennial plant belonging to the family Lamiaceae, mostly found on rocky pastures, dry meadows, and abandoned places of the Mediterranean area...
  8. Duesterdieck Zellmer K, Driscoll N, Ott J. Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1?. Am J Vet Res. 2012;73:1530-9 pubmed
    ..effects of tiludronate on cartilage explants incubated with or without recombinant equine interleukin-1? (rEq IL-1). Articular cartilage explants from the femorotibial joints of 3 young adult horses...
  9. Nirgianakis K, Lanz S, Imboden S, Worni M, Mueller M. Coagulation-Induced Diaphragm Fenestrations after Laparoscopic Excision of Diaphragmatic Endometriosis. J Minim Invasive Gynecol. 2018;25:771-772 pubmed publisher
    ..Institutional Review Board/Ethics Committee ruled that approval was not required for this study (Req-2017-00415)...

More Information

Publications42

  1. Fern J, Nitkowski D, Petermann U, Petermann F. [Functional and dysfunctional emotion regulation strategies for depressive symptoms in adolescents]. Z Kinder Jugendpsychiatr Psychother. 2018;46:17-27 pubmed publisher
    ..Method: The Regulation of Emotions Questionnaire (REQ) was used to examine the ability of emotion regulation in 247 adolescents between 12 to 17 years (M = 14.41, SD = 1...
  2. Janda J, Lehmann M, Luttmann W, Marti E. Cloning and expression of recombinant equine interleukin-3 and its effect on sulfidoleukotriene and cytokine production by equine peripheral blood leukocytes. Vet Immunol Immunopathol. 2015;163:202-9 pubmed publisher
    ..Recombinant equine IL-3 (req-IL-3) had a dose dependent effect on sLT production by stimulated equine PBL and significantly increased IL-4, IL-..
  3. Rivas E, Rao M, Castleberry T, Ben Ezra V. The change in metabolic heat production is a primary mediator of heat acclimation in adults. J Therm Biol. 2017;70:69-79 pubmed publisher
    ..Heat loss required (Ereq) to maintain steady state internal temperature (Ereq = 220 ± 32Wm-2), maximal capacity ..
  4. Ravanelli N, Gagnon D, Hodder S, Havenith G, Jay O. The biophysical and physiological basis for mitigated elevations in heart rate with electric fan use in extreme heat and humidity. Int J Biometeorol. 2017;61:313-323 pubmed publisher
    ..temperatures, and the combined convective/radiative heat loss (C+R), evaporative heat balance requirements (Ereq) and maximum evaporative potential (Emax) were assessed...
  5. Balmain B, Jay O, Sabapathy S, Royston D, Stewart G, Jayasinghe R, et al. Altered thermoregulatory responses in heart failure patients exercising in the heat. Physiol Rep. 2016;4: pubmed
    ..Metabolic heat production (Hprod) and the evaporative requirements for heat balance (Ereq) were also calculated...
  6. de Abreu A, de Oliveira B. A study of the Unna Boot compared with the elastic bandage in venous ulcers: a randomized clinical trial. Rev Lat Am Enfermagem. 2015;23:571-7 pubmed publisher
    ..Brazilian Clinical Trials Register: Trial (req: 195) and WHO UTN U1111-1122-5489.
  7. Leites G, Cunha G, Obeid J, Wilk B, Meyer F, Timmons B. Thermoregulation in boys and men exercising at the same heat production per unit body mass. Eur J Appl Physiol. 2016;116:1411-9 pubmed publisher
    ..710 ± 150 mL; P = 0.041), despite the same evaporative heat balance requirement (E req) (199.1 ± 34.2 vs. 201.0 ± 32.7 W, P = 0.87)...
  8. Priebojová J, Hilscherova K, Procházková T, Sychrova E, Smutná M. Intracellular and extracellular retinoid-like activity of widespread cyanobacterial species. Ecotoxicol Environ Saf. 2018;150:312-319 pubmed publisher
    ..Total produced retinoid-like activity of five selected species ranged from 170 to 25,600ng ATRA-equivalents (REQ)/g dm corresponding to 0.001-0.392ng REQ/106 cyanobacterial cells...
  9. Sinha S, Chatterjee S, Biswas M, Nag A, Banerjee D, De R, et al. SWI/SNF subunit expression heterogeneity in human aplastic anemia stem/progenitors. Exp Hematol. 2018;62:39-44.e2 pubmed publisher
    ..However, expression of SMARCA4, SMARCB1, SMARCD3, and DPF2 remained intact in our AA cohort...
  10. Vasileiou G, Vergarajauregui S, Endele S, Popp B, Büttner C, Ekici A, et al. Mutations in the BAF-Complex Subunit DPF2 Are Associated with Coffin-Siris Syndrome. Am J Hum Genet. 2018;102:468-479 pubmed publisher
    ..two splice site, and five missense) in the gene encoding the BAF complex subunit double plant homeodomain finger 2 (DPF2)...
  11. Smutna M, Priebojová J, Večerková J, Hilscherova K. Retinoid-like compounds produced by phytoplankton affect embryonic development of Xenopus laevis. Ecotoxicol Environ Saf. 2017;138:32-38 pubmed publisher
    ..The retinoid-like activity determined by in vitro reporter gene assay reached 528ng retinoid equivalents (REQ)/L and 1000ng REQ/L in exudates of Cylindrospermopsis raciborskii and Microcystis aeruginosa, respectively, while ..
  12. Božović M, Garzoli S, Sabatino M, Pepi F, Baldisserotto A, Andreotti E, et al. Essential Oil Extraction, Chemical Analysis and Anti-Candida Activity of Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) Ball-New Approaches. Molecules. 2017;22: pubmed publisher
    A comprehensive study on essential oils extracted from different Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) Ball samples from Tarquinia (Italy) is reported...
  13. Chestkov A, Baka I, Kost M, Georgiev G, Buchman V. The d4 gene family in the human genome. Genomics. 1996;36:174-7 pubmed
    ..The conservation of d4 proteins from nematodes to vertebrates suggests that they have a general importance, but a diversity of d4 proteins expressed in vertebrate nervous systems suggests that some family members have special functions. ..
  14. Zhang W, Xu C, Bian C, Tempel W, Crombet L, MacKenzie F, et al. Crystal structure of the Cys2His2-type zinc finger domain of human DPF2. Biochem Biophys Res Commun. 2011;413:58-61 pubmed publisher
    b>DPF2 is an evolutionary highly conserved member of the d4-protein family characterized by an N-terminal 2/3 domain, a C2H2-type zinc finger (ZF), and a C-terminal tandem PHD zinc finger...
  15. Lim Y, Mantalaris A, Yap M, Wong D. Simultaneous targeting of Requiem & Alg-2 in Chinese hamster ovary cells for improved recombinant protein production. Mol Biotechnol. 2010;46:301-7 pubmed publisher
    ..This in turn led to an approximately 1.5-fold increase in recombinant protein productivity. ..
  16. Kobayashi K, Hiramatsu H, Nakamura S, Kobayashi K, Haraguchi T, Iba H. Tumor suppression via inhibition of SWI/SNF complex-dependent NF-κB activation. Sci Rep. 2017;7:11772 pubmed publisher
    ..We previously reported that the d4-family proteins (DPF1, DPF2, DPF3a/b) function as adaptor proteins linking NF-κB with the SWI/SNF complex...
  17. Kaeser M, Aslanian A, Dong M, Yates J, Emerson B. BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. J Biol Chem. 2008;283:32254-63 pubmed publisher
    ..Taken together, our results provide insight into the function of compositionally diverse SWI/SNF enzymes that underlie their inherent gene-specific mode of action. ..
  18. Geor R, McCutcheon L, Ecker G, Lindinger M. Heat storage in horses during submaximal exercise before and after humid heat acclimation. J Appl Physiol (1985). 2000;89:2283-93 pubmed
    ..The ratios of required evaporative capacity to maximal evaporative capacity of the environment (E(req)/E(max)) for CD, HD, and HH were approximately 1.2, 1.6, and 2.5, respectively...
  19. Villanueva Chimal E, Salinas L, Fernández Cardenas L, Huelgas Morales G, Cabrera Wrooman A, Navarro R. DPFF-1 transcription factor deficiency causes the aberrant activation of MPK-1 and meiotic defects in the Caenorhabditis elegans germline. Genesis. 2017;55: pubmed publisher
    ..b>DPF2/requiem/ubi-d4 is expressed ubiquitously and presumably functions as an apoptotic factor, especially during the ..
  20. Shin D, Lee J, Park J, Min J. Double Plant Homeodomain Fingers 2 (DPF2) Promotes the Immune Escape of Influenza Virus by Suppressing Beta Interferon Production. J Virol. 2017;91: pubmed publisher
    ..using RNA interference and focused on one of the identified host factors, the double plant homeodomain fingers 2 (DPF2/REQ) gene, for this study...
  21. Cruickshank V, Sroczynska P, Sankar A, Miyagi S, Rundsten C, Johansen J, et al. SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance. PLoS ONE. 2015;10:e0142806 pubmed publisher
    ..Here we further explore the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia...
  22. Gao H, Mangion K, Carrick D, Husmeier D, Luo X, Berry C. Estimating prognosis in patients with acute myocardial infarction using personalized computational heart models. Sci Rep. 2017;7:13527 pubmed publisher
    ..included normalized active tension (AT norm) and active tension at the resting sarcomere length (T req, reflecting required contractility)...
  23. Gabig T, Mantel P, Rosli R, Crean C. Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells. J Biol Chem. 1994;269:29515-9 pubmed
    ..Requiem is likely to encode a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. ..
  24. Mahajan M, Narlikar G, Boyapaty G, Kingston R, Weissman S. Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc Natl Acad Sci U S A. 2005;102:15012-7 pubmed
    ..Independently of the initiation of transcription, LARC becomes associated with beta-like globin promoters. ..
  25. Xiong X, Panchenko T, Yang S, Zhao S, Yan P, Zhang W, et al. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2. Nat Chem Biol. 2016;12:1111-1118 pubmed publisher
    ..acetylation-binding double PHD finger (DPF) domains of human MOZ (also known as KAT6A) and DPF2 (also known as BAF45d) accommodate a wide range of histone lysine acylations with the strongest preference for Kcr...
  26. Liu C, Zhang D, Shen Y, Tao X, Liu L, Zhong Y, et al. DPF2 regulates OCT4 protein level and nuclear distribution. Biochim Biophys Acta. 2015;1853:3279-93 pubmed publisher
    ..Here, we report that DPF2, a plant homeodomain (PHD) finger protein, is upregulated during H9 cell differentiation induced by retinoic acid...
  27. Gabig T, Crean C, Klenk A, Long H, Copeland N, Gilbert D, et al. Expression and chromosomal localization of the Requiem gene. Mamm Genome. 1998;9:660-5 pubmed
    ..The gene is located in the proximal region of mouse Chromosome (Chr) 19. In the homologous human region at 11q13, it is located at about 150 kb centromeric from MLK3. ..
  28. Guru S, Agarwal S, Manickam P, Olufemi S, Crabtree J, Weisemann J, et al. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. Genome Res. 1997;7:725-35 pubmed
    ..8-Mb D11S480-D11S913 interval. Fifteen candidate genes (of which 10 were examined exhaustively) were evaluated by Southern blot and/or dideoxy fingerprinting analysis to identify the gene harboring disease-causing mutations. ..
  29. Li X, Foley E, Kawashima S, Molloy K, Li Y, Chait B, et al. Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach. Protein Sci. 2013;22:287-95 pubmed publisher
    ..Together, our findings indicate the CLASPI approach can be broadly applied to profile protein-protein interactions mediated by PTMs. ..
  30. Ninkina N, Mertsalov I, Kulikova D, Alimova Kost M, Simonova O, Korochkin L, et al. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. Mamm Genome. 2001;12:862-6 pubmed
    Two members of the d4 family of presumptive transcription modulators, neuro-d4 (Neud4) and ubi-d4/Requiem (Req), have been characterized previously...
  31. Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, et al. Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. J Biol Chem. 2010;285:21951-60 pubmed publisher
    ..In this study, we identify the human requiem protein (REQ/DPF2) as an adaptor molecule that links the NF-kappaB and SWI/SNF chromatin remodeling factor...
  32. Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, et al. Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-?B RelA/p50 heterodimer. J Biol Chem. 2012;287:11924-33 pubmed publisher
    We have previously shown that DPF2 (requiem/REQ) functions as a linker protein between the SWI/SNF complex and RelB/p52 NF-?B heterodimer and plays important roles in NF-?B transactivation via its noncanonical pathway...
  33. Huber F, Greenblatt S, Davenport A, Martínez C, Xu Y, Vu L, et al. Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Proc Natl Acad Sci U S A. 2017;114:6016-6021 pubmed publisher
    Double plant homeodomain finger 2 (DPF2) is a highly evolutionarily conserved member of the d4 protein family that is ubiquitously expressed in human tissues and was recently shown to inhibit the myeloid differentiation of hematopoietic ..