doublecortin

Summary

Gene Symbol: doublecortin
Description: doublecortin
Alias: DBCN, LISX, SCLH, XLIS, neuronal migration protein doublecortin, doublecortex, doublin, lis-X, lissencephalin-X
Species: human
Products:     doublecortin

Top Publications

  1. Des Portes V, Pinard J, Billuart P, Vinet M, Koulakoff A, Carrie A, et al. A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. Cell. 1998;92:51-61 pubmed
    ..We report the characterization of a novel CNS gene encoding a 40 kDa predicted protein that we named Doublecortin and the identification of mutations in four unrelated X-SCLH/LIS cases...
  2. Gleeson J, Lin P, Flanagan L, Walsh C. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron. 1999;23:257-71 pubmed
    b>Doublecortin (DCX) is required for normal migration of neurons into the cerebral cortex, since mutations in the human gene cause a disruption of cortical neuronal migration...
  3. Gleeson J, Allen K, Fox J, Lamperti E, Berkovic S, Scheffer I, et al. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell. 1998;92:63-72 pubmed
    ..interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Doublecortin. Four double cortex/X-linked lissencephaly families and three sporadic double cortex patients show independent ..
  4. Des Portes V, Francis F, Pinard J, Desguerre I, Moutard M, Snoeck I, et al. doublecortin is the major gene causing X-linked subcortical laminar heterotopia (SCLH). Hum Mol Genet. 1998;7:1063-70 pubmed
    ..This clinical entity has been described as X-SCLH/LIS syndrome. Recently we have demonstrated that the doublecortin gene, which is localized on the X chromosome, is implicated in this disorder...
  5. Kim M, Cierpicki T, Derewenda U, Krowarsch D, Feng Y, Devedjiev Y, et al. The DCX-domain tandems of doublecortin and doublecortin-like kinase. Nat Struct Biol. 2003;10:324-33 pubmed
    The doublecortin-like domains (DCX), which typically occur in tandem, are novel microtubule-binding modules...
  6. Schaar B, Kinoshita K, McConnell S. Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons. Neuron. 2004;41:203-13 pubmed
    b>Doublecortin (Dcx) is a microtubule-associated protein that is mutated in X-linked lissencephaly (X-LIS), a neuronal migration disorder associated with epilepsy and mental retardation...
  7. Bielas S, Serneo F, Chechlacz M, Deerinck T, Perkins G, Allen P, et al. Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist. Cell. 2007;129:579-91 pubmed
    ..a Protein-phosphatase 1 (PP1) targeting protein, is responsible for the dephosphorylation of the MAP Doublecortin (Dcx) Ser 297 selectively at the "wrist" of growing axons, leading to activation...
  8. Zhang Y, Ryan J, Di Cesare P, Liu J, Walsh C, You Z. Doublecortin is expressed in articular chondrocytes. Biochem Biophys Res Commun. 2007;363:694-700 pubmed
    ..In this study, we found that doublecortin (DCX) was expressed in articular chondrocytes but not in chondrocytes from the cartilaginous anlagen or growth ..
  9. Dijkmans T, van Hooijdonk L, Fitzsimons C, Vreugdenhil E. The doublecortin gene family and disorders of neuronal structure. Cent Nerv Syst Agents Med Chem. 2010;10:32-46 pubmed
    The doublecortin gene family is associated with subcortical band heterotopia, lissencephaly, epilepsy, developmental dyslexia and retinitis pigmentosa. At least 11 genes homologous to the doublecortin gene exist in humans and mice...

More Information

Publications136 found, 100 shown here

  1. de Miranda A, Brant F, Campos A, Vieira L, Rocha N, Cisalpino D, et al. Evidence for the contribution of adult neurogenesis and hippocampal cell death in experimental cerebral malaria cognitive outcome. Neuroscience. 2015;284:920-33 pubmed publisher
    ..Neurogenesis in the dentate gyrus was determined through quantification of doublecortin (DCX) positive cells. PbA-infected mice presented working memory impairment on day 5 post-infection...
  2. Lee J, Espinera A, Chen D, Choi K, Caslin A, Won S, et al. Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats. J Neuroinflammation. 2016;13:109 pubmed publisher
    ..The number of bromodeoxyuridine (BrdU) and doublecortin (DCX) double-positive cells in the hippocampal dentate gyrus of P21 rats was significantly lower than that in ..
  3. Han T, Leem Y, Kim H. Treadmill exercise restores high fat diet-induced disturbance of hippocampal neurogenesis through β2-adrenergic receptor-dependent induction of thioredoxin-1 and brain-derived neurotrophic factor. Brain Res. 2019;1707:154-163 pubmed publisher
    ..test and recovered HFD-induced anti-neurogenic effects as shown by immunohistochemistry data with Ki-67 and doublecortin (DCX) antibodies...
  4. Lee W, Moon M, Kim H, Lee T, Oh M. Heat stress-induced memory impairment is associated with neuroinflammation in mice. J Neuroinflammation. 2015;12:102 pubmed publisher
    ..Moreover, in heat-exposed mice, we found that the number of cells positive for doublecortin (DCX), a marker of neurogenesis, was significantly decreased compared with control mice...
  5. Zhang Z, Wang H, Jin Z, Cai X, Gao N, Cui X, et al. Downregulation of survivin regulates adult hippocampal neurogenesis and apoptosis, and inhibits spatial learning and memory following traumatic brain injury. Neuroscience. 2015;300:219-28 pubmed publisher
    ..Brain slices were stained for 5'-bromo-2'-deoxyuridine (BrdU) and doublecortin (DCX)...
  6. Zhang K, Yang J, Wang F, Pan X, Liu J, Wang L, et al. Antidepressant-like effects of Xiaochaihutang in a neuroendocrine mouse model of anxiety/depression. J Ethnopharmacol. 2016;194:674-683 pubmed publisher
    ..In addition, Ki-67 and doublecortin (DCX) were performed to assess hippocampal cell proliferation and neurogenesis by immunohistochemistry...
  7. Zhang C, Zeng M, Zhou L, Li Y, Zhao F, Shang Z, et al. Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression. Int Immunopharmacol. 2018;64:175-182 pubmed publisher
    ..showed that administration of BA improved depressive-like behaviors and significantly increased the levels of doublecortin (DCX), Neuron-specific enolase (NSE), and Brain-derived neurotrophic factor (BDNF) in hippocampus...
  8. Kim G, Lim K, Yang H, Lee J, Kim Y, Park S, et al. Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models. J Chem Neuroanat. 2019;98:27-40 pubmed publisher
    ..These results identify PF as a potential therapy for enhancing memory functions and prevention of Alzheimer's disease through actions on the hippocampus. ..
  9. Kesidou E, Touloumi O, Lagoudaki R, Nousiopoulou E, Theotokis P, Poulatsidou K, et al. Humoral response in experimental autoimmune encephalomyelitis targets neural precursor cells in the central nervous system of naive rodents. J Neuroinflammation. 2017;14:227 pubmed publisher
    ..Thus, our findings provide indication that cross-talk between immunity and NPCs may lead to functional alteration of NPCs regarding their viability and potentially oligodendrogenesis and effective remyelination. ..
  10. Pavlov D, Bettendorff L, Gorlova A, Olkhovik A, Kalueff A, Ponomarev E, et al. Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies. Prog Neuropsychopharmacol Biol Psychiatry. 2019;90:104-116 pubmed publisher
  11. Hutton C, Déry N, Rosa E, Lemon J, Rollo C, Boreham D, et al. Synergistic effects of diet and exercise on hippocampal function in chronically stressed mice. Neuroscience. 2015;308:180-93 pubmed publisher
    ..of dietary supplementation and exercise had multiple beneficial effects, as reflected in the number of doublecortin (DCX)-positive immature neurons in the dentate gyrus (DG), the sectional area of the DG and hippocampal CA1, as ..
  12. Kim H, Chadwick L, Alzaidi Y, Picker J, Poduri A, Manzi S. HLA-A*31:01 and Oxcarbazepine-Induced DRESS in a Patient With Seizures and Complete DCX Deletion. Pediatrics. 2018;141:S434-S438 pubmed publisher
    ..Finally, we discuss the potential utility of preemptive pharmacogenomic screening of patients before pharmacological treatment of epilepsy to assess the risk of developing hypersensitivity reactions. ..
  13. Wang W, Lu L, Bao T, Zhang H, Yuan J, Miao W, et al. Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells. J Mol Neurosci. 2016;58:210-20 pubmed publisher
    ..to the oligodendrocyte and neuronal lineages, as evidenced by NG2 chondroitin sulfate proteoglycan (NG2) and doublecortin (DCX) staining...
  14. Chien M, Chuang C, Chern C, Liou K, Liu D, Hou Y, et al. Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice. Free Radic Biol Med. 2016;99:508-519 pubmed publisher
    ..dentate gyrus by compromising the activation of GSK3? and p25/Cdk5, which in turn upregulated ?-catenin, doublecortin (DCX), and Bcl-2, most possibly through the activation of PI3K/Akt signaling via the upregulation of brain-..
  15. Moon H, Javadi S, Stremlau M, Yoon K, Becker B, Kang S, et al. Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells. Neuropharmacology. 2019;145:123-130 pubmed publisher
    ..Treatment of aNPCs with a specific fraction of the AICAR-CM upregulated expression of doublecortin (DCX) and Tuj1, markers of immature neurons...
  16. Singhakumar R, Boontem P, Ekthuwapranee K, Sotthibundhu A, Mukda S, Chetsawang B, et al. Melatonin attenuates methamphetamine-induced inhibition of neurogenesis in the adult mouse hippocampus: An in vivo study. Neurosci Lett. 2015;606:209-14 pubmed publisher
    ..results showed that METH caused a decrease in neuronal phenotypes as determined by the expressions of nestin, doublecortin (DCX) and beta-III tubulin while causing an increase in glial fibrillary acidic protein (GFAP) expression...
  17. Ma J, Wang F, Yang J, Dong Y, Su G, Zhang K, et al. Xiaochaihutang attenuates depressive/anxiety-like behaviors of social isolation-reared mice by regulating monoaminergic system, neurogenesis and BDNF expression. J Ethnopharmacol. 2017;208:94-104 pubmed publisher
    ..The findings indicate that XCHT may have a therapeutic application for early-life stress model of depression and in turn provide further evidence supporting XCHT a novel potential antidepressant from a distinct perspective. ..
  18. Cipriani R, Chara J, Rodríguez Antigüedad A, Matute C. Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury. J Neuroinflammation. 2017;14:147 pubmed publisher
    ..analyses were performed on rat brain slices to measure the production of new neuronal precursors (doublecortin/DCX+ cells) and new oligodendrocytes precursors (proteoglycan/NG2+ cells)...
  19. Genestine M, Lin L, Durens M, Yan Y, Jiang Y, Prem S, et al. Engrailed-2 (En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior. Hum Mol Genet. 2015;24:5805-27 pubmed publisher
    ..These studies suggest that disruption of hindbrain patterning genes can alter monoamine system development and thereby produce forebrain defects that are relevant to human neurodevelopmental disorders. ..
  20. Luo L, Li C, Du X, Shi Q, Huang Q, Xu X, et al. Effect of aerobic exercise on BDNF/proBDNF expression in the ischemic hippocampus and depression recovery of rats after stroke. Behav Brain Res. 2019;362:323-331 pubmed publisher
    ..HE staining and immunostaining for doublecortin (DCX)+ neurons were used to observe the changes of neuronal cell morphology and proliferation, ..
  21. Moraga A, Pradillo J, García Culebras A, Palma Tortosa S, Ballesteros I, Hernández Jiménez M, et al. Aging increases microglial proliferation, delays cell migration, and decreases cortical neurogenesis after focal cerebral ischemia. J Neuroinflammation. 2015;12:87 pubmed publisher
    ..Thus, our results highlight the importance of using aged animals for translation to clinical studies. ..
  22. Perez S, Du K, Rendeiro C, Wang L, Wu Q, Rubakhin S, et al. A unique combination of micronutrients rejuvenates cognitive performance in aged mice. Behav Brain Res. 2017;320:97-112 pubmed publisher
    ..Number of immature neurons were measured by immunohistochemical detection of doublecortin (DCX+) in the granule layer of the dentate gyrus...
  23. Zonis S, Breunig J, Mamelak A, Wawrowsky K, Bresee C, Ginzburg N, et al. Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. J Neuroinflammation. 2018;15:260 pubmed publisher
    ..galactosidase and the cell cycle inhibitor p16 and suppressing neuroblast proliferation and expression of doublecortin (DCX) and neuron-specific class III beta-tubulin (Tuj-1), both neuroblast markers, while promoting ..
  24. Flowers A, Lee J, Acosta S, Hudson C, Small B, Sanberg C, et al. NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats. J Neuroinflammation. 2015;12:174 pubmed publisher
    ..NeuN-positive cells showed a basal increase in nuclear β-catenin in the aged rats, which was not observed in doublecortin (DCX)-labeled cells, microglia, or astrocytes...
  25. Grubić Kezele T, Blagojević Zagorac G, Jakovac H, Domitrovic R, Radosević Stasić B. Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats. Histol Histopathol. 2017;32:137-151 pubmed publisher
    ..in subgranular zone (SGZ) of DA rats an augmented number of GFAP+ precursors, but decreased number of doublecortin (DCX)+ neuroblasts and immature NeuN+ neurons were found, implying that in DA rats the neurogenesis was delayed ..
  26. Klein B, Mrowetz H, Thalhamer J, Scheiblhofer S, Weiss R, Aigner L. Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus. Front Cell Neurosci. 2016;10:169 pubmed publisher
    ..e., cells expressing doublecortin (DCX). The number of DCX(+) cells was clearly increased in the allergy animals...
  27. Pinkas A, Turgeman G, Tayeb S, Yanai J. An avian model for ascertaining the mechanisms of organophosphate neuroteratogenicity and its therapy with mesenchymal stem cell transplantation. Neurotoxicol Teratol. 2015;50:73-81 pubmed publisher
  28. Kim T, Sung Y. Regular exercise promotes memory function and enhances hippocampal neuroplasticity in experimental autoimmune encephalomyelitis mice. Neuroscience. 2017;346:173-181 pubmed publisher
    ..basic protein (MBP), 2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNPase), 5-bromo-2'-deoxyuridine (brdU), doublecortin (DCX), bcl-2, bax, TUNEL, caspase-3, and brain derived neurotrophic factor (BDNF) via immunoassay or ..
  29. Xing H, Zhang K, Zhang R, Shi H, Bi K, Chen X. Antidepressant-like effect of the water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium and Magnolia officinalis in a rat model of chronic unpredictable mild stress. Phytomedicine. 2015;22:1178-85 pubmed publisher
    ..neurotrophic factor (BDNF) in hippocampus was measured, as well as hippocampal neurogenesis was investigated by doublecortin (DCX) and 5-bromo-2-deoxyuridine/neuronal nuclei (BrdU/NeuN)...
  30. Seth B, Yadav A, Agarwal S, Tiwari S, Chaturvedi R. Inhibition of the transforming growth factor-β/SMAD cascade mitigates the anti-neurogenic effects of the carbamate pesticide carbofuran. J Biol Chem. 2017;292:19423-19440 pubmed publisher
    ..Therefore, we conclude that TGF-β may represent a potential therapeutic target against carbofuran-mediated neurotoxicity and neurogenesis disruption. ..
  31. Sakharkar A, Vetreno R, Zhang H, Kokare D, Crews F, Pandey S. A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. Brain Struct Funct. 2016;221:4691-4703 pubmed
    ..Similarly, neurogenesis was inhibited by AIE in adulthood as demonstrated by the decrease in Ki-67 and doublecortin (DCX)-positive cells in the dentate gyrus, which was normalized by TSA treatment...
  32. Zhang Y, Xu C, Zheng H, Loh H, Law P. Morphine Modulates Adult Neurogenesis and Contextual Memory by Impeding the Maturation of Neural Progenitors. PLoS ONE. 2016;11:e0153628 pubmed publisher
    ..markers, we observed that morphine reduced the number of late stage progenitors and immature neurons such as Doublecortin (DCX) and βIII Tubulin (TuJ1) positive cells in the SGZ but did not reduce the number of early progenitors ..
  33. Shetty A, Hattiangady B. Grafted Subventricular Zone Neural Stem Cells Display Robust Engraftment and Similar Differentiation Properties and Form New Neurogenic Niches in the Young and Aged Hippocampus. Stem Cells Transl Med. 2016;5:1204-15 pubmed publisher
    ..In both age groups, graft cores located in non-neurogenic regions displayed many doublecortin-positive (DCX+) immature neurons at 3 months after grafting...
  34. Nishijima T, Kamidozono Y, Ishiizumi A, Amemiya S, Kita I. Negative rebound in hippocampal neurogenesis following exercise cessation. Am J Physiol Regul Integr Comp Physiol. 2017;312:R347-R357 pubmed publisher
    ..Exercise resulted in a significant increase in the density of doublecortin (DCX)-positive immature neurons in the dentate gyrus (at week 0)...
  35. Bermudez Hernandez K, Lu Y, Moretto J, Jain S, Lafrancois J, Duffy A, et al. Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX. Brain Struct Funct. 2017;222:3147-3161 pubmed publisher
    ..Most hilar Prox1-positive cells at PND16 co-expressed doublecortin (DCX) and calretinin, markers of immature GCs...
  36. Liu J, REEVES C, Jacques T, McEvoy A, Miserocchi A, Thompson P, et al. Nestin-expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity. Glia. 2018;66:62-77 pubmed publisher
  37. Ma F, Martínez San Segundo P, Barceló V, Morancho A, Gabriel Salazar M, Giralt D, et al. Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice. Neurobiol Dis. 2016;91:236-46 pubmed publisher
    ..Together, our results indicate that MMP-13 is a central protease in infarct development and cortical remodeling during post-stroke neurorepair, which is critical for optimal angiogenic and neurogenic responses. ..
  38. Lian D, He D, Wu J, Liu Y, Zhu M, Sun J, et al. Exogenous BDNF increases neurogenesis in the hippocampus in experimental Streptococcus pneumoniae meningitis. J Neuroimmunol. 2016;294:46-55 pubmed publisher
    ..Administration of exogenous BDNF might improve the neurogenesis of endogenous NSCs in the hippocampus and may provide a promising therapy after bacterial meningitis. ..
  39. Oliveros A, Cho C, Cui A, Choi S, Lindberg D, Hinton D, et al. Adenosine A2A receptor and ERK-driven impulsivity potentiates hippocampal neuroblast proliferation. Transl Psychiatry. 2017;7:e1095 pubmed publisher
    ..is associated with hippocampal neuroblast development, we investigated expression of BrdU+ and doublecortin (DCX+) following 5-CSRTT testing...
  40. Amrein I, Nosswitz M, Slomianka L, van Dijk R, Engler S, Klaus F, et al. Septo-temporal distribution and lineage progression of hippocampal neurogenesis in a primate (Callithrix jacchus) in comparison to mice. Front Neuroanat. 2015;9:85 pubmed publisher
    ..This clear dissociation between DCX+ and CR+ young neurons has not been reported for other species and may therefore represent a key primate-specific feature of adult hippocampal neurogenesis. ..
  41. Fu S, Jiang W, Gao X, Zeng A, Cholger D, Cannon J, et al. Aberrant Adult Neurogenesis in the Subventricular Zone-Rostral Migratory Stream-Olfactory Bulb System Following Subchronic Manganese Exposure. Toxicol Sci. 2016;150:347-68 pubmed publisher
    ..In the OB, however, Mn exposure significantly reduces the surviving adult-born cells and markedly inhibits their differentiation into mature neurons, resulting in an overall decreased adult neurogenesis in the OB. ..
  42. Stenger M, Klein K, Grønnemose R, Klitgaard J, Kolmos H, Lindholt J, et al. Co-release of dicloxacillin and thioridazine from catheter material containing an interpenetrating polymer network for inhibiting device-associated Staphylococcus aureus infection. J Control Release. 2016;241:125-134 pubmed publisher
    ..Lastly, the IPN catheters were tested in a novel porcine model of central venous catheter-related infection, in which drug-loaded IPN catheters were found to significantly decrease the frequency of infection. ..
  43. Stenger M, Behr Rasmussen C, Klein K, Grønnemose R, Andersen T, Klitgaard J, et al. Systemic thioridazine in combination with dicloxacillin against early aortic graft infections caused by Staphylococcus aureus in a porcine model: In vivo results do not reproduce the in vitro synergistic activity. PLoS ONE. 2017;12:e0173362 pubmed publisher
    ..However, unexpected severe adverse effects related to the planned dose of TDZ required a considerable reduction to the administered dose of TDZ, which may have compromised the results. ..
  44. Poser R, Dokter M, von Bohlen Und Halbach V, Berger S, Busch R, Baldus M, et al. Impact of a deletion of the full-length and short isoform of p75NTR on cholinergic innervation and the population of postmitotic doublecortin positive cells in the dentate gyrus. Front Neuroanat. 2015;9:63 pubmed publisher
    ..Furthermore, adult neurogenesis in the DG was found to be significantly altered with increased numbers of doublecortin (DCX) positive cells and reduced numbers of apoptotic cells in p75NTR (ExIV) knockout mice...
  45. Kim Y, Nam T, Park C, Kim S, Yoon W, Choi S, et al. Familial pachygyria in both genders related to a DCX mutation. Brain Dev. 2016;38:585-9 pubmed publisher
    b>Doublecortin (DCX) and tubulin play critical roles in neuronal migration. DCX mutations usually cause anterior dominant lissencephaly in males and subcortical band heterotopia (SBH) in females...
  46. Chen B, Park J, Cho J, Kim I, Lee J, Lee T, et al. Tanshinone I Enhances Neurogenesis in the Mouse Hippocampal Dentate Gyrus via Increasing Wnt-3, Phosphorylated Glycogen Synthase Kinase-3? and ?-Catenin Immunoreactivities. Neurochem Res. 2016;41:1958-68 pubmed publisher
    ..neuronal differentiation in the subgranular zone (SGZ) of the mouse dentate gyrus (DG) using Ki-67, BrdU and doublecortin (DCX) immunohistochemistry. Mice were treated with 1 and 2 mg/kg TsI for 28 days...
  47. Nam S, Kim J, Kwon H, Yoo D, Jung H, Kim D, et al. Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice. Neurochem Res. 2017;42:3149-3159 pubmed publisher
    ..Compared to the CD-fed mice, HFD-feeding elicited the reduction of neurogenic markers such as nestin, Ki67, doublecortin (DCX), and 5-bromo-2'-deoxyuridine (BrdU) in the dentate gyrus...
  48. Bengoa Vergniory N, Gorroño Etxebarria I, López Sánchez I, Marra M, Di Chiaro P, Kypta R. Identification of Noncanonical Wnt Receptors Required for Wnt-3a-Induced Early Differentiation of Human Neural Stem Cells. Mol Neurobiol. 2017;54:6213-6224 pubmed publisher
  49. Xu Y, He F, Qi F, Yang G, Zheng F, Yang J, et al. Remodeling the Th1 polarized systemic environment contributes to neurogenesis and cognitive function via the Wnt7a pathway in neonatal mice. Neurobiol Learn Mem. 2017;141:60-71 pubmed publisher
  50. Schiavon A, Bonato J, Milani H, Guimarães F, Weffort de Oliveira R. Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice. Prog Neuropsychopharmacol Biol Psychiatry. 2016;64:27-34 pubmed publisher
    ..3 mg/kg) increased cell proliferation and neurogenesis, as seen by an increased number of Ki-67-, BrdU- and doublecortin (DCX)-positive cells in both in DG and SVZ...
  51. Tian X, Sun L, Feng D, Sun Q, Dou Y, Liu C, et al. HMGB1 promotes neurovascular remodeling via Rage in the late phase of subarachnoid hemorrhage. Brain Res. 2017;1670:135-145 pubmed publisher
    ..In conclusion, our investigation identified that HMGB1 promotes neurovascular recovery via Rage and may act in the oxidized state in the late stage of SAH. ..
  52. Li H, Karl T, Garner B. Abca7 deletion does not affect adult neurogenesis in the mouse. Biosci Rep. 2016;36: pubmed publisher
    ..study of cell proliferation and neurogenic potential using cellular bromodeoxyuridine (BrdU) incorporation and doublecortin (DCX) immunostaining in adult Abca7 deficient mice and wild-type-like (WT) littermates...
  53. Li M, Qian S. Gastrodin Protects Neural Progenitor Cells Against Amyloid ? (1-42)-Induced Neurotoxicity and Improves Hippocampal Neurogenesis in Amyloid ? (1-42)-Injected Mice. J Mol Neurosci. 2016;60:21-32 pubmed publisher
    ..administration of GAS could improve hippocampal neurogenesis, manifested by the increased number of SOX-2 and doublecortin (DCX)-positive cells in the DG area...
  54. Ahmed M, Tucker D, Dong Y, Lu Y, Zhao N, Wang R, et al. Methylene Blue promotes cortical neurogenesis and ameliorates behavioral deficit after photothrombotic stroke in rats. Neuroscience. 2016;336:39-48 pubmed publisher
  55. Kappeler C, Dhenain M, Phan Dinh Tuy F, Saillour Y, Marty S, Fallet Bianco C, et al. Magnetic resonance imaging and histological studies of corpus callosal and hippocampal abnormalities linked to doublecortin deficiency. J Comp Neurol. 2007;500:239-54 pubmed
    Mutated doublecortin (DCX) gives rise to severe abnormalities in human cortical development. Adult Dcx knockout mice show no major neocortical defects but do have a disorganized hippocampus...
  56. Fernández López B, Romaus Sanjurjo D, Senra Martínez P, Anadón R, Barreiro Iglesias A, Rodicio M. Spatiotemporal Pattern of Doublecortin Expression in the Retina of the Sea Lamprey. Front Neuroanat. 2016;10:5 pubmed publisher
    Despite the importance of doublecortin (DCX) for the development of the nervous system, its expression in the retina of most vertebrates is still unknown...
  57. Liu F, Ni J, Sun F. Expression of Phospho-MeCP2s in the Developing Rat Brain and Function of Postnatal MeCP2 in Cerebellar Neural Cell Development. Neurosci Bull. 2017;33:1-16 pubmed publisher
  58. Guigueno M, MacDougall Shackleton S, Sherry D. Sex and seasonal differences in hippocampal volume and neurogenesis in brood-parasitic brown-headed cowbirds (Molothrus ater). Dev Neurobiol. 2016;76:1275-1290 pubmed publisher
    ..Females had a larger hippocampus than males in both species, but hippocampal neurogenesis, measured by doublecortin immunoreactivity (DCX+), was greater in female than in male cowbirds in the absence of any sex difference in ..
  59. Csabai D, Csekő K, Szaiff L, Varga Z, Miseta A, Helyes Z, et al. Low intensity, long term exposure to tobacco smoke inhibits hippocampal neurogenesis in adult mice. Behav Brain Res. 2016;302:44-52 pubmed publisher
    ..To investigate the effect of tobacco smoke on the population of immature neurons, we quantified the number of doublecortin-positive (DCX+) neurons in the same animals...
  60. Shiraki A, Tanaka T, Watanabe Y, Saito F, Akahori Y, Imatanaka N, et al. Immunohistochemistry of aberrant neuronal development induced by 6-propyl-2-thiouracil in rats. Toxicol Lett. 2016;261:59-71 pubmed publisher
    ..In contrast, only hippocampal neurogenesis was sensitive to adult-stage exposure. ..
  61. Tseng K, Anttila J, Khodosevich K, Tuominen R, Lindahl M, Domanskyi A, et al. MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke. Mol Ther. 2018;26:238-255 pubmed publisher
    ..injections of MANF did not affect cell proliferation in the SVZ, but promoted migration of doublecortin (DCX)+ cells toward the corpus callosum and infarct boundary on day 14 post-stroke...
  62. Sakurai M, Suzuki H, Tomita N, Sunden Y, Shimada A, Miyata H, et al. Enhanced neurogenesis and possible synaptic reorganization in the piriform cortex of adult rat following kainic acid-induced status epilepticus. Neuropathology. 2018;38:135-143 pubmed publisher
    ..These results suggested the enhanced neurogenesis and possible synaptic reorganization in the piriform cortex of the KA-treated rat. ..
  63. Subhash V, Tan S, Tan W, Yeo M, Xie C, Wong F, et al. GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells. BMC Cancer. 2015;15:550 pubmed publisher
    ..This study also suggests the repressive role of GTSE1 in cisplatin induced apoptosis and signifies its potential utility as a therapeutic target for better clinical management of gastric cancer patients. ..
  64. Zhang G, Guo X, Chen L, Li B, Gu B, Wang H, et al. Interferon-? promotes neuronal repair by transplanted neural stem cells in ischemic rats. Stem Cells Dev. 2018;: pubmed publisher
    ..Thus, our findings suggest that co-delivery of NSCs and IFN-? without genetic modification may be an effective, simple, and novel approach for the treatment of ischemic stroke. ..
  65. Parsons White A, Spitzer N. Environmentally relevant manganese overexposure alters neural cell morphology and differentiation in vitro. Toxicol In Vitro. 2018;50:22-28 pubmed publisher
    ..These effects of Mn overexposure on brain cell function could underlie manganism and neurocognitive and developmental defects associated with environmental Mn overexposure. ..
  66. Burger D, Stihle M, Sharma A, Di Lello P, Benz J, D Arcy B, et al. Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies. J Biol Chem. 2016;291:16292-306 pubmed publisher
    b>Doublecortin is a microtubule-associated protein produced during neurogenesis. The protein stabilizes microtubules and stimulates their polymerization, which allows migration of immature neurons to their designated location in the brain...
  67. Zeke A, Misheva M, Remenyi A, Bogoyevitch M. JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships. Microbiol Mol Biol Rev. 2016;80:793-835 pubmed publisher
    ..These advances open new opportunities to understand the role of JNK signaling in diverse physiological and pathophysiological states. ..
  68. Unger M, Marschallinger J, Kaindl J, Höfling C, Rossner S, Heneka M, et al. Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease. Mol Neurobiol. 2016;53:5796-806 pubmed publisher
    ..Moreover and surprisingly, proliferation of doublecortin (DCX) expressing neuroblasts was significantly and specifically elevated during the pre-plaque stage in the APP-..
  69. Suliman N, Taib C, Moklas M, Basir R. Delta-9-Tetrahydrocannabinol (∆9-THC) Induce Neurogenesis and Improve Cognitive Performances of Male Sprague Dawley Rats. Neurotox Res. 2018;33:402-411 pubmed publisher
    ..The brains were stained with antibodies, namely BrdU, glial fibrillary acidic protein (GFAP), nestin, doublecortin (DCX) and class III β-tubulin (TuJ-1)...
  70. Lau C, Mulet X, Konstas K, Doherty C, Sani M, Separovic F, et al. Hypercrosslinked Additives for Ageless Gas-Separation Membranes. Angew Chem Int Ed Engl. 2016;55:1998-2001 pubmed publisher
    ..This reduces particle-size effects and the internal free volume is almost unchanged over time. This study shows this inexpensive and scalable polymer additive delivers exceptional gas-transport performance and selectivity. ..
  71. Ettinger A, van Haren J, Ribeiro S, Wittmann T. Doublecortin Is Excluded from Growing Microtubule Ends and Recognizes the GDP-Microtubule Lattice. Curr Biol. 2016;26:1549-1555 pubmed publisher
    ..b>Doublecortin (DCX), a MT-associated protein (MAP) required for neuronal migration during cortical development [4, 5], binds ..
  72. Chawana R, Patzke N, Alagaili A, Bennett N, Mohammed O, Kaswera Kyamakya C, et al. The Distribution of Ki-67 and Doublecortin Immunopositive Cells in the Brains of Three Microchiropteran Species, Hipposideros fuliginosus, Triaenops persicus, and Asellia tridens. Anat Rec (Hoboken). 2016;299:1548-1560 pubmed publisher
    This study uses Ki-67 and doublecortin (DCX) immunohistochemistry to delineate potential neurogenic zones, migratory pathways, and terminal fields associated with adult neurogenesis in the brains of three microchiropterans...
  73. Nagayasu E, Hwang Y, Liu J, Murray J, Hu K. Loss of a doublecortin (DCX)-domain protein causes structural defects in a tubulin-based organelle of Toxoplasma gondii and impairs host-cell invasion. Mol Biol Cell. 2017;28:411-428 pubmed publisher
    ..One candidate for this role is TgDCX, which has a doublecortin (DCX) domain and a TPPP/P25-? domain, both of which are known modulators of tubulin polymer structure...
  74. Bae J, Han M, Shin H, Shon D, Lee S, Shin C, et al. Lycopersicon esculentum Extract Enhances Cognitive Function and Hippocampal Neurogenesis in Aged Mice. Nutrients. 2016;8: pubmed
    ..The TEE supplement increased doublecortin (DCX)-positive cells and postsynaptic density-95 (PSD95) expression in mice hippocampus...
  75. Li X, Sun D, Li X, Zhu D, Jia Z, Jiao J, et al. PEGylation corannulene enhances response of stress through promoting neurogenesis. Biomater Sci. 2017;5:849-859 pubmed publisher
    ..Furthermore, pathological analysis showed that PEGylation CoNps caused little inflammation. These findings suggest that PEGylation CoNps are a potential functionalized carbon nanomaterial for promoting neurogenesis. ..
  76. Gleeson J, Minnerath S, Fox J, Allen K, Luo R, Hong S, et al. Characterization of mutations in the gene doublecortin in patients with double cortex syndrome. Ann Neurol. 1999;45:146-53 pubmed
    Mutations in the X-linked gene doublecortin, which encodes a protein with no dear structural homologues, are found in pedigrees in which affected females show "double cortex" syndrome (DC; also known as subcortical band ..
  77. Bernreuther C, Salein N, Matschke J, Hagel C. Expression of doublecortin in tumours of the central and peripheral nervous system and in human non-neuronal tissues. Acta Neuropathol. 2006;111:247-54 pubmed
    b>Doublecortin is a microtubule-associated phosphoprotein involved in neuronal migration and differentiation expressed in migrating neuroblasts in the central nervous system...
  78. Masui K, Mawatari S, Suzuki S, Iwaki T. Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells. Brain Tumor Pathol. 2008;25:1-7 pubmed publisher
    ..b>Doublecortin (DCX) is a microtubule-associated protein (MAP) that plays a crucial role in neuroblast migration...
  79. Takeshita S, Higuchi M, Suyama M, Koide W, Maki K, Ushijima K, et al. Novel DCX mutation-caused lissencephaly in a boy and very mild heterotopia in his mother. Pediatr Int. 2015;57:321-3 pubmed publisher
    ..conclude that a DCX mutation causes a pleiotropic phenotype in the female even if X chromosome inactivation pattern is not skewed, and the novel missense mutation in DCX produced relatively mild dysfunction of the doublecortin protein.
  80. Khalaf Nazzal R, Stouffer M, Olaso R, Muresan L, Roumegous A, Lavilla V, et al. Early born neurons are abnormally positioned in the doublecortin knockout hippocampus. Hum Mol Genet. 2017;26:90-108 pubmed publisher
    Human doublecortin (DCX) mutations are associated with severe brain malformations leading to aberrant neuron positioning (heterotopia), intellectual disability and epilepsy...
  81. Schomann T, Mezzanotte L, de Groot J, Rivolta M, Hendriks S, Frijns J, et al. Neuronal differentiation of hair-follicle-bulge-derived stem cells co-cultured with mouse cochlear modiolus explants. PLoS ONE. 2017;12:e0187183 pubmed publisher
    ..explants without hair cells were co-cultured with DCX-copGFP-transduced HFBSCs, which demonstrate copGFP upon doublecortin expression during neuronal differentiation...
  82. Kato M, Kimura T, Lin C, Ito A, Kodama S, Morikawa T, et al. A novel mutation of the doublecortin gene in Japanese patients with X-linked lissencephaly and subcortical band heterotopia. Hum Genet. 1999;104:341-4 pubmed
    The doublecortin (DCX) gene was recently found to be involved in patients with X-linked lissencephaly and subcortical band heterotopia or double cortex syndrome...
  83. Matsumoto N, Leventer R, Kuc J, Mewborn S, Dudlicek L, Ramocki M, et al. Mutation analysis of the DCX gene and genotype/phenotype correlation in subcortical band heterotopia. Eur J Hum Genet. 2001;9:5-12 pubmed
    ..LIS and SBH are caused by alterations in at least two genes: LIS1 (PAFAH1B1) at 17p13.3 and DCX (doublecortin) at Xq22.3-q23...
  84. Friocourt G, Chafey P, Billuart P, Koulakoff A, Vinet M, Schaar B, et al. Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system. Mol Cell Neurosci. 2001;18:307-19 pubmed
    b>Doublecortin is a microtubule-associated protein required for normal corticogenesis in the developing brain. We carried out a yeast two-hybrid screen to identify interacting proteins...
  85. Kato M, Kanai M, Soma O, Takusa Y, Kimura T, Numakura C, et al. Mutation of the doublecortin gene in male patients with double cortex syndrome: somatic mosaicism detected by hair root analysis. Ann Neurol. 2001;50:547-51 pubmed
    ..We conclude that somatic mosaic mutations in the doublecortin gene in male patients can cause subcortical band heterotopia, and that molecular analysis using hair roots is a ..
  86. Friocourt G, Kappeler C, Saillour Y, Fauchereau F, Rodriguez M, Bahi N, et al. Doublecortin interacts with the ubiquitin protease DFFRX, which associates with microtubules in neuronal processes. Mol Cell Neurosci. 2005;28:153-64 pubmed
    b>Doublecortin (DCX) is a microtubule-associated protein involved in neuronal migration, which causes X-linked lissencephaly and subcortical laminar heterotopia (SCLH) when mutated...
  87. Lawrence K, Mei D, Newton M, Leventer R, Guerrini R, Berkovic S. Familial Lennox-Gastaut syndrome in male siblings with a novel DCX mutation and anterior pachygyria. Epilepsia. 2010;51:1902-5 pubmed publisher
    ..Neuroimaging revealed anterior predominant pachygyria. DNA sequencing of the gene doublecortin (DCX) on the X chromosome revealed a novel missense mutation in the two living affected male siblings...
  88. Quelin C, Saillour Y, Souville I, Poirier K, N guyen Morel M, Vercueil L, et al. Mosaic DCX deletion causes subcortical band heterotopia in males. Neurogenetics. 2012;13:367-73 pubmed publisher
    ..is a neuronal migration disorder usually described in females carrying heterozygous mutations in the X-linked doublecortin (DCX) gene. Hemizygous DCX mutations in males result in lissencephaly...
  89. Yáñez Y, Hervás D, Grau E, Oltra S, Pérez G, Palanca S, et al. TH and DCX mRNAs in peripheral blood and bone marrow predict outcome in metastatic neuroblastoma patients. J Cancer Res Clin Oncol. 2016;142:573-80 pubmed publisher
    ..This study aims to evaluate the independent prognostic significance of detecting tyrosine hydroxylase (TH) and doublecortin (DCX) mRNAs by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) in peripheral blood (PB) ..
  90. Soares L, De Vry J, Steinbusch H, Milani H, Prickaerts J, Weffort de Oliveira R. Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia. Neuroscience. 2016;326:69-83 pubmed publisher
    ..the effects of rolipram on hippocampal neurodegeneration and the expression of the neuronal plasticity markers doublecortin (DCX) and microtubule-associated protein (MAP-2)...
  91. Spritzer M, Panning A, Engelman S, Prince W, Casler A, Georgakas J, et al. Seasonal and sex differences in cell proliferation, neurogenesis, and cell death within the dentate gyrus of adult wild-caught meadow voles. Neuroscience. 2017;360:155-165 pubmed publisher
    ..Overall, these results suggest higher levels of neuronal turn-over during the non-breeding season relative to the breeding season, possibly due to seasonal changes in sex steroids. ..
  92. Lai F, Fagernes C, Bernier N, Miller G, Munday P, Jutfelt F, et al. Responses of neurogenesis and neuroplasticity related genes to elevated CO2 levels in the brain of three teleost species. Biol Lett. 2017;13: pubmed publisher
    ..to elevated CO2 The mRNA expression levels of the neurogenic differentiation factor (NeuroD) and doublecortin (DCX) were upregulated in three-spined stickleback exposed to high-CO2 compared with controls, while ..