dopamine transporter

Summary

Gene Symbol: dopamine transporter
Description: solute carrier family 6 member 3
Alias: DAT, DAT1, PKDYS, sodium-dependent dopamine transporter, DA transporter, dopamine transporter 1, solute carrier family 6 (neurotransmitter transporter), member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Species: human
Products:     dopamine transporter

Top Publications

  1. Dreher J, Kohn P, Kolachana B, Weinberger D, Berman K. Variation in dopamine genes influences responsivity of the human reward system. Proc Natl Acad Sci U S A. 2009;106:617-22 pubmed publisher
    In humans, dopamine neurotransmission is influenced by functional polymorphisms in the dopamine transporter (DAT1) and catechol-O-methyltransferase (COMT) genes...
  2. Laucht M, Becker K, Frank J, Schmidt M, Esser G, Treutlein J, et al. Genetic variation in dopamine pathways differentially associated with smoking progression in adolescence. J Am Acad Child Adolesc Psychiatry. 2008;47:673-81 pubmed publisher
    ..intention to quit was significantly lower in adolescents homozygous for the 10-repeat allele of the common dopamine transporter 3' untranslated region polymorphism...
  3. Soderqvist S, Bergman Nutley S, Peyrard Janvid M, Matsson H, Humphreys K, Kere J, et al. Dopamine, working memory, and training induced plasticity: implications for developmental research. Dev Psychol. 2012;48:836-43 pubmed publisher
    ..Novel data are presented showing that variation in the dopamine transporter gene (DAT1) influences improvements in WM and fluid intelligence in preschool-age children following ..
  4. Guptaroy B, Zhang M, Bowton E, Binda F, Shi L, Weinstein H, et al. A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation. Mol Pharmacol. 2009;75:514-24 pubmed publisher
    The human dopamine transporter (hDAT) regulates synaptic dopamine (DA) levels and is the site of action of abused and therapeutic drugs...
  5. Stevens S, Kumsta R, Kreppner J, Brookes K, Rutter M, Sonuga Barke E. Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: developmental continuities in gene-environment interplay. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:753-61 pubmed publisher
    ..Individuals were genotyped for polymorphisms in the dopamine D4 receptor (DRD4 48-bp VNTR in exon 3) and dopamine transporter gene (DAT1 haplotypes combining a 40-bp VNTR in 3'UTR and a 30-bp VNTR in intron 8)...
  6. da Silva N, Szobot C, Anselmi C, Jackowski A, Chi S, Hoexter M, et al. Attention deficit/hyperactivity disorder: is there a correlation between dopamine transporter density and cerebral blood flow?. Clin Nucl Med. 2011;36:656-60 pubmed publisher
    ..of the dopaminergic system has been suggested by genetic studies that report an overexpression of the dopamine transporter (DAT) gene...
  7. Treister R, Pud D, Ebstein R, Laiba E, Gershon E, Haddad M, et al. Associations between polymorphisms in dopamine neurotransmitter pathway genes and pain response in healthy humans. Pain. 2009;147:187-93 pubmed publisher
    ..promoter region of the monoamine oxidase-A gene (MAO-A), 40-bp repeat in the 3'-untranslated region of the dopamine transporter gene (DAT-1), and 48-bp repeat in the exon 3 of the dopamine receptor 4 gene (DRD4) were examined...
  8. Epstein L, Temple J, Neaderhiser B, Salis R, Erbe R, Leddy J. Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. Behav Neurosci. 2007;121:877-86 pubmed
    The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old...
  9. van de Giessen E, de Win M, Tanck M, van den Brink W, Baas F, Booij J. Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3. J Nucl Med. 2009;50:45-52 pubmed publisher
    Polymorphisms in the dopamine transporter (DAT) gene SLC6A3 are associated with human striatal DAT expression, but the exact effects on DAT expression are not clear...

More Information

Publications78

  1. Mata R, Hau R, Papassotiropoulos A, Hertwig R. DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART). PLoS ONE. 2012;7:e39135 pubmed publisher
    ..Analogue Risk Task, BART) and a variable number tandem repeat (VNTR) polymorphism in the 3'UTR of the dopamine transporter gene (SLC6A3/DAT1)...
  2. Shumay E, Fowler J, Volkow N. Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity. PLoS ONE. 2010;5:e11067 pubmed publisher
    Human dopamine transporter gene (DAT1 or SLC6A3) has been associated with various brain-related diseases and behavioral traits and, as such, has been investigated intensely in experimental- and clinical-settings...
  3. Costa A, Riedel M, Muller U, Möller H, Ettinger U. Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studies. Synapse. 2011;65:998-1005 pubmed publisher
    The human dopamine transporter (DAT) gene (SLC6A3) contains a 40-bp variable number of tandem repeats (VNTR) polymorphism...
  4. Saiz P, García Portilla M, Arango C, Morales B, Arias B, Corcoran P, et al. Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: Data from an association study. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:26-31 pubmed publisher
    ..63), p=0.019]. This study provides evidence that a genetic variant in the DRD2 gene and possible interaction between DRD3 and SLC6A3 genes are associated with schizophrenia. These findings warrant examination in replication studies. ..
  5. Malyuchenko N, Schegolkova J, Kulikova M, Timofeeva M, Shlepzova V, Sysoeva O, et al. Effects of genetic variations in the dopaminergic system on fatigue in humans: gender aspects. Bull Exp Biol Med. 2010;149:226-32 pubmed
    ..the functional status under the effect of intense mental exercise were studied in carriers of different variants of DAT1, DRD2, and COMT genes...
  6. Kniazeff J, Shi L, Loland C, Javitch J, Weinstein H, Gether U. An intracellular interaction network regulates conformational transitions in the dopamine transporter. J Biol Chem. 2008;283:17691-701 pubmed publisher
    ..Here we combine computational modeling and experimental probing in the dopamine transporter (DAT) to demonstrate the functional importance of a conserved intracellular interaction network...
  7. Lohoff F, Bloch P, Hodge R, Nall A, Ferraro T, Kampman K, et al. Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence. Neurosci Lett. 2010;473:87-91 pubmed publisher
    ..The dopamine receptor D(2) (DRD2) protein and dopamine transporter (DAT1) protein play regulatory roles in dopamine neurotransmission...
  8. Prata D, Mechelli A, Fu C, Picchioni M, Toulopoulou T, Bramon E, et al. Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proc Natl Acad Sci U S A. 2009;106:13600-5 pubmed publisher
    ..in the modulation of neurocognitive function, and synaptic dopamine activity is normally regulated by the dopamine transporter (DAT) and catechol-O-methyltransferase (COMT)...
  9. Singh M, Khan A, Shah P, Shukla R, Khanna V, Parmar D. Polymorphism in environment responsive genes and association with Parkinson disease. Mol Cell Biochem. 2008;312:131-8 pubmed publisher
    ..allele frequencies was observed for manganese-superoxide dismutase (MnSOD), dopamine receptor-D2(DRD2), and dopamine transporter (DAT) genes between controls and PD cases...
  10. Burt S, Mikolajewski A. Preliminary evidence that specific candidate genes are associated with adolescent-onset antisocial behavior. Aggress Behav. 2008;34:437-45 pubmed publisher
    ..e., tryptophan hydroxylase-A218C, 5HT(2A) His452Tyr, and the DAT1 variable nucleotide tandem repeat) were genotyped. Analyses revealed that two of the three polymorphisms (i.e...
  11. Valente N, Vallada H, Cordeiro Q, Miguita K, Bressan R, Andreoli S, et al. Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF. J Mol Neurosci. 2011;44:59-67 pubmed publisher
    ..study, whether the brain-derived neurotrophic factor (BDNF) val66met polymorphism (rs6265), the dopamine transporter (DAT1) three prime untranslated region (3'UTR) variable number of tandem repeats (VNTR), and the serotonin ..
  12. Scherk H, Backens M, Schneider Axmann T, Kraft S, Kemmer C, Usher J, et al. Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen. World J Biol Psychiatry. 2009;10:524-30 pubmed
    Dopaminergic activity in the brain is modulated by the dopamine transporter (DAT). Several lines of evidence suggest that a variable number of tandem repeats (VNTR) polymorphism of the DAT1 gene (SLC6A3) influences its gene expression...
  13. Althaus M, Groen Y, Wijers A, Minderaa R, Kema I, Dijck J, et al. Variants of the SLC6A3 (DAT1) polymorphism affect performance monitoring-related cortical evoked potentials that are associated with ADHD. Biol Psychol. 2010;85:19-32 pubmed publisher
    Although the 10-repeat (10R) variant of the dopamine transporter gene (DAT1 or SLC6A3) is suggested to be a risk allele for Attention Deficit Hyperactivity Disorder (ADHD) no relationships between DAT1 and measures of cognition in ..
  14. Guindalini C, Martins R, Andersen M, Tufik S. Influence of genotype on dopamine transporter availability in human striatum and sleep architecture. Psychiatry Res. 2010;179:238-40 pubmed publisher
    Genetic variants may modulate dopamine transporter (DAT) availability in the brain. A polymorphism within the intron 8 of the DAT1 gene was evaluated in 27 healthy men...
  15. Styn M, Nukui T, Romkes M, Perkins K, Land S, Weissfeld J. The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:254-61 pubmed publisher
    ..The association between DRD2 TaqIA and smoking cessation supports the hypothesis that genetic variation in the dopamine pathway influences smoking cessation. ..
  16. Brehmer Y, Westerberg H, Bellander M, Fürth D, Karlsson S, Backman L. Working memory plasticity modulated by dopamine transporter genotype. Neurosci Lett. 2009;467:117-20 pubmed publisher
    Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum...
  17. van der Zwaluw C, Engels R, Buitelaar J, Verkes R, Franke B, Scholte R. Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic review. Pharmacogenomics. 2009;10:853-66 pubmed publisher
    ..The dopamine transporter terminates dopaminergic neurotransmission, making the gene encoding the transporter (SLC6A3/DAT1) an ..
  18. Shumay E, Chen J, Fowler J, Volkow N. Genotype and ancestry modulate brain's DAT availability in healthy humans. PLoS ONE. 2011;6:e22754 pubmed publisher
    The dopamine transporter (DAT) is a principal regulator of dopaminergic neurotransmission and its gene (the SLC6A3) is a strong biological candidate gene for various behavioral- and neurological disorders...
  19. Garcia Garcia M, Clemente I, Domínguez Borràs J, Escera C. Dopamine transporter regulates the enhancement of novelty processing by a negative emotional context. Neuropsychologia. 2010;48:1483-8 pubmed publisher
    ..Forty healthy volunteers were genotyped for the dopamine transporter (DAT) gene SLC6A3 or DAT1 and performed an auditory-visual distraction paradigm in negative and neutral ..
  20. Alexander N, Osinsky R, Mueller E, Schmitz A, Guenthert S, Kuepper Y, et al. Genetic variants within the dopaminergic system interact to modulate endocrine stress reactivity and recovery. Behav Brain Res. 2011;216:53-8 pubmed publisher
    ..variations that affect dopamine availability in both cortical (COMT Val¹??Met polymorphism) and subcortical (DAT1 VNTR) brain regions on HPA-axis reactivity to psychosocial stress...
  21. Hahn T, Heinzel S, Dresler T, Plichta M, Renner T, Markulin F, et al. Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype. Hum Brain Mapp. 2011;32:1557-65 pubmed publisher
    ..magnetic resonance imaging, trait reward sensitivity, and dopamine (DA) transporter genotype (40-bp 3'VNTR of DAT, SLC6A3) affecting synaptic DA neurotransmission...
  22. Franke B, Hoogman M, Arias Vasquez A, Heister J, Savelkoul P, Naber M, et al. Association of the dopamine transporter (SLC6A3/DAT1) gene 9-6 haplotype with adult ADHD. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1576-9 pubmed publisher
    ..The gene that has received most attention in ADHD genetics is SLC6A3/DAT1 encoding the dopamine transporter. In the current study we attempted to replicate in adults with ADHD the reported association of a 10-6 ..
  23. Frank M, Fossella J. Neurogenetics and pharmacology of learning, motivation, and cognition. Neuropsychopharmacology. 2011;36:133-52 pubmed publisher
    ..a role for genes controlling dopaminergic function in frontostriatal circuitry, including COMT, DARPP-32, DAT1, DRD2, and DRD4...
  24. Bailey J, Goenjian A, Noble E, Walling D, Ritchie T, Goenjian H. PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake. Psychiatry Res. 2010;178:507-10 pubmed publisher
    The objective of this study was to assess the generality of the association of DRD2 and DAT genes and Post-Traumatic Stress Disorder (PTSD) diagnosis/symptom severity...
  25. Adkins E, Samuvel D, Fog J, Eriksen J, Jayanthi L, Vaegter C, et al. Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching. Biochemistry. 2007;46:10484-97 pubmed
    To investigate microdomain association of the dopamine transporter (DAT), we employed FCS (fluorescence correlation spectroscopy) and FRAP (fluorescence recovery after photobleaching)...
  26. Forbes E, Brown S, Kimak M, Ferrell R, Manuck S, Hariri A. Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. Mol Psychiatry. 2009;14:60-70 pubmed
    ..Genetic variants associated with relatively increased striatal DA release (DRD2 -141C deletion) and availability (DAT1 9-repeat), as well as diminished inhibitory postsynaptic DA effects (DRD2 -141C deletion and DRD4 7-repeat), ..
  27. Fuemmeler B, Agurs Collins T, McClernon F, Kollins S, Kail M, Bergen A, et al. Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. Obesity (Silver Spring). 2008;16:348-55 pubmed publisher
    ..Our findings lend further support to the involvement of genes implicated in dopamine and serotonin regulation on energy balance. ..
  28. Pinsonneault J, Han D, Burdick K, Kataki M, Bertolino A, Malhotra A, et al. Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder. Neuropsychopharmacology. 2011;36:1644-55 pubmed publisher
    The gene encoding the dopamine transporter (DAT) has been implicated in CNS disorders, but the responsible polymorphisms remain uncertain...
  29. Caldu X, Vendrell P, Bartrés Faz D, Clemente I, Bargallo N, Jurado M, et al. Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects. Neuroimage. 2007;37:1437-44 pubmed
    Two limiting factors of dopamine activity are the catechol-o-methyltransferase (COMT) and the dopamine transporter (DAT), which terminate dopamine activity by degradation and uptake, respectively...
  30. Ritz B, Manthripragada A, Costello S, Lincoln S, Farrer M, Cockburn M, et al. Dopamine transporter genetic variants and pesticides in Parkinson's disease. Environ Health Perspect. 2009;117:964-9 pubmed publisher
    Research suggests that independent and joint effects of genetic variability in the dopamine transporter (DAT) locus and pesticides may influence Parkinson's disease (PD) risk.
  31. Lim J, Ebstein R, Tse C, Monakhov M, Lai P, Dinges D, et al. Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test. PLoS ONE. 2012;7:e33767 pubmed publisher
    ..The 10-repeat allele of the variable number of tandem repeats marker (VNTR) in the dopamine transporter gene and the Met allele of the catechol-o-methyl transferase (COMT) Val158Met polymorphism were associated ..
  32. Franklin T, Lohoff F, Wang Z, Sciortino N, Harper D, Li Y, et al. DAT genotype modulates brain and behavioral responses elicited by cigarette cues. Neuropsychopharmacology. 2009;34:717-28 pubmed publisher
    ..Evidence suggests that a variable number of tandem repeats (VNTRs) polymorphism in the DA transporter (DAT) SLC6A3 gene may influence DA transport...
  33. Rommelse N, Altink M, Arias Vasquez A, Buschgens C, Fliers E, Faraone S, et al. A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHD. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1536-46 pubmed publisher
    Meta-analyses indicate that the gene coding for the dopamine transporter (DAT1 or SLC6A3) is associated with an increased risk for ADHD. The mechanisms of this gene for ADHD are unclear...
  34. Schmid B, Blomeyer D, Becker K, Treutlein J, Zimmermann U, Buchmann A, et al. The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds. Addict Biol. 2009;14:489-99 pubmed publisher
    ..in the age at onset could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with alcohol and nicotine consumption...
  35. Drury S, Theall K, Keats B, Scheeringa M. The role of the dopamine transporter (DAT) in the development of PTSD in preschool children. J Trauma Stress. 2009;22:534-9 pubmed publisher
    ..This study explored the influence of genetic variation in the dopamine transporter (DAT) 3' untranslated region variable number tandem repeat on the development of PTSD in preschool children ..
  36. Han D, Joe K, Na C, Lee Y. Effect of genetic polymorphisms on smoking cessation: a trial of bupropion in Korean male smokers. Psychiatr Genet. 2008;18:11-6 pubmed publisher
    ..frequencies of the A1/A2 genotype of the dopamine receptor type 2 TaqI A gene and SLC6A3-9 genotype of the dopamine transporter 1 gene were higher in the nonabstinence group than in the abstinence group (chi2=20.40, P<0...
  37. Brown A, Biederman J, Valera E, Makris N, Doyle A, Whitfield Gabrieli S, et al. Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networks. Psychiatry Res. 2011;193:7-16 pubmed publisher
    Alterations in working memory, default-mode network (DMN), and dopamine transporter have all been proposed as endophenotypes for attention-deficit/hyperactivity disorder (ADHD)...
  38. Haeffel G, Getchell M, Koposov R, Yrigollen C, DeYoung C, Klinteberg B, et al. Association between polymorphisms in the dopamine transporter gene and depression: evidence for a gene-environment interaction in a sample of juvenile detainees. Psychol Sci. 2008;19:62-9 pubmed publisher
    ..Using a gene-by-environment (G x E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15...
  39. Dresler T, Ehlis A, Heinzel S, Renner T, Reif A, Baehne C, et al. Dopamine transporter (SLC6A3) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD. Neuropsychopharmacology. 2010;35:2193-202 pubmed publisher
    ..a common variable number of tandem repeats (VNTR) polymorphism in the 3' untranslated region (UTR) of the dopamine transporter gene (SLC6A3) has been repeatedly associated with the disorder...
  40. Perkins K, Lerman C, Grottenthaler A, Ciccocioppo M, Milanak M, Conklin C, et al. Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood. Behav Pharmacol. 2008;19:641-9 pubmed publisher
    ..These results warrant replication but provide the first evidence for genetic associations with the acute increase in smoking reward and reinforcement owing to negative mood. ..
  41. Aarts E, Roelofs A, Franke B, Rijpkema M, Fernandez G, Helmich R, et al. Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging. Neuropsychopharmacology. 2010;35:1943-51 pubmed publisher
    ..We fill this gap by using fMRI, a novel behavioral paradigm and a common polymorphism in the DAT1 gene (SLC6A3)...
  42. Zhong S, Chark R, Ebstein R, Chew S. Imaging genetics for utility of risks over gains and losses. Neuroimage. 2012;59:540-6 pubmed publisher
    ..Stratifying brain activation by genotype, we find that a well-characterized polymorphism in the dopamine transporter (DAT1) contributes to individual differences in striatal response for gain-oriented risks, whereas a ..
  43. Simon J, Stollstorff M, Westbay L, Vaidya C, Howard J, Howard D. Dopamine transporter genotype predicts implicit sequence learning. Behav Brain Res. 2011;216:452-7 pubmed publisher
    ..We examined relationships between a variation of the dopamine transporter (DAT1) gene (SLC6A3), which influences dopamine transporter expression in the striatum, and two forms of ..
  44. Blanchard M, Chamberlain S, Roiser J, Robbins T, Muller U. Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers. Psychol Med. 2011;41:611-8 pubmed publisher
    ..The dopamine transporter and catechol-O-methyltransferase (COMT) are proteins involved in dopamine clearance and the dopamine system ..
  45. Rokem A, Landau A, Prinzmetal W, Wallace D, Silver M, D ESPOSITO M. Modulation of inhibition of return by the dopamine D2 receptor agonist bromocriptine depends on individual DAT1 genotype. Cereb Cortex. 2012;22:1133-8 pubmed publisher
    ..IOR depends on striatal dopamine (DA) levels: It varies with different alleles of the DA transporter gene DAT1 and is reduced in patients with Parkinson's disease, a disease characterized by reduced striatal ..
  46. Stollstorff M, Foss Feig J, Cook E, Stein M, Gaillard W, Vaidya C. Neural response to working memory load varies by dopamine transporter genotype in children. Neuroimage. 2010;53:970-7 pubmed publisher
    Inheriting two (10/10) relative to one (9/10) copy of the 10-repeat allele of the dopamine transporter genotype (DAT1) is associated with Attention Deficit Hyperactivity Disorder, a childhood disorder marked by poor executive function...
  47. Gizer I, Ficks C, Waldman I. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet. 2009;126:51-90 pubmed publisher
    ..Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25...
  48. Binda F, Dipace C, Bowton E, Robertson S, Lute B, Fog J, et al. Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol Pharmacol. 2008;74:1101-8 pubmed publisher
    ..Here, we define the first 33 amino acids of the N terminus of the dopamine (DA) transporter (DAT) as the site of direct interaction with SYN1A...
  49. Durston S, Fossella J, Mulder M, Casey B, Ziermans T, Vessaz M, et al. Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation. J Am Acad Child Adolesc Psychiatry. 2008;47:61-7 pubmed publisher
    The dopamine transporter (DAT1) gene has been implicated in attention-deficit/hyperactivity disorder (ADHD), although the mechanism by which it exerts its effects remains unknown...
  50. Todt U, Netzer C, Toliat M, Heinze A, Goebel I, Nurnberg P, et al. New genetic evidence for involvement of the dopamine system in migraine with aura. Hum Genet. 2009;125:265-79 pubmed publisher
    ..Our data provide new evidence for an involvement of components of the dopaminergic system-in particular the dopamine-beta hydroxylase and dopamine transporter genes-to the pathogenesis of migraine with aura.
  51. Bowton E, Saunders C, Erreger K, Sakrikar D, Matthies H, Sen N, et al. Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. J Neurosci. 2010;30:6048-57 pubmed publisher
    ..regulatory mechanisms, DA D(2) receptor (D(2)R)-mediated inhibition of DA synthesis and release, and DA transporter (DAT)-mediated DA clearance...
  52. Genro J, Polanczyk G, Zeni C, Oliveira A, Roman T, Rohde L, et al. A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1568-75 pubmed publisher
    The dopamine transporter (DAT) is the major site of methylphenidate action, which is one of the main drugs used to treat attention-deficit/hyperactivity disorder (ADHD)...
  53. Puffenberger E, Jinks R, Sougnez C, Cibulskis K, Willert R, Achilly N, et al. Genetic mapping and exome sequencing identify variants associated with five novel diseases. PLoS ONE. 2012;7:e28936 pubmed publisher
    ..Our results reveal the power of coupling new genotyping technologies to population-specific genetic knowledge and robust clinical data. ..
  54. Franke B, Vasquez A, Johansson S, Hoogman M, Romanos J, Boreatti Hümmer A, et al. Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD. Neuropsychopharmacology. 2010;35:656-64 pubmed publisher
    ..DAT1, encoding the dopamine transporter, is one of the most frequently studied genes in ADHD, though results have been inconsistent...
  55. Kurian M, Li Y, Zhen J, Meyer E, Hai N, Christen H, et al. Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. Lancet Neurol. 2011;10:54-62 pubmed publisher
    b>dopamine transporter deficiency syndrome is the first identified parkinsonian disorder caused by genetic alterations of the dopamine transporter...
  56. Levine A, Sinsheimer J, Bilder R, Shapshak P, Singer E. Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults. J Clin Exp Neuropsychol. 2012;34:78-91 pubmed publisher
    Dopaminergic dysfunction is a putative mechanism underlying HIV-associated neurocognitive disorders. Dopamine transporter (DAT), brain-derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) have been specifically ..
  57. Becker K, El Faddagh M, Schmidt M, Esser G, Laucht M. Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms. J Pediatr. 2008;152:263-9 pubmed publisher
    To demonstrate that children homozygous for the 10-repeat allele of the common dopamine transporter (DAT1) polymorphism who were exposed to maternal prenatal smoke exhibited significantly higher hyperactivity-impulsivity than children ..
  58. Wonodi I, Hong L, Stine O, Mitchell B, Elliott A, Roberts R, et al. Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:282-9 pubmed publisher
    ..Recent evidence implicates the dopamine transporter gene (DAT1) in modulating cortical dopamine and associated neurocognitive functions...
  59. Bertolino A, Fazio L, Di Giorgio A, Blasi G, Romano R, Taurisano P, et al. Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. J Neurosci. 2009;29:1224-34 pubmed publisher
    ..Both the dopamine transporter (DAT) and dopamine D(2) receptors (encoded by DRD(2)) critically regulate dopamine signaling in the ..
  60. Kazantseva A, Gaysina D, Malykh S, Khusnutdinova E. The role of dopamine transporter (SLC6A3) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) gene polymorphisms in personality traits. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:1033-40 pubmed publisher
    ..002). Our findings provide evidence for a modifying effect of gender on the associations between dopamine system genes and approach-related traits (in men) and Persistence (in women). ..
  61. Bedard A, Schulz K, Cook E, Fan J, Clerkin S, Ivanov I, et al. Dopamine transporter gene variation modulates activation of striatum in youth with ADHD. Neuroimage. 2010;53:935-42 pubmed publisher
    Polymorphisms in the 3'UTR variable number tandem repeat (VNTR) of exon 15 of the dopamine transporter gene (DAT1) have been linked to attention-deficit hyperactivity disorder (ADHD); moreover, variability in DAT1 3'UTR genotype may ..
  62. Guo G, Cai T, Guo R, Wang H, Harris K. The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors. PLoS ONE. 2010;5:e9352 pubmed publisher
    This study tests the specific hypothesis that the 9R/9R genotype in the VNTR of the dopamine transporter gene (DAT1) exerts a general protective effect against a spectrum of risky behaviors in comparison to the 10R/9R and 10R/10R ..
  63. McClernon F, Fuemmeler B, Kollins S, Kail M, Ashley Koch A. Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. Nicotine Tob Res. 2008;10:117-27 pubmed publisher
    ..We observed neither main effects nor interactions with CYP2A6, DAT, and SLC6A4 genes...
  64. Bertolino A, Di Giorgio A, Blasi G, Sambataro F, Caforio G, Sinibaldi L, et al. Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks. Biol Psychiatry. 2008;64:226-34 pubmed publisher
    ..the effect of genetic variation of dopamine inactivation via catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT) on hippocampal activity in healthy humans during different memory conditions...
  65. Shan J, Javitch J, Shi L, Weinstein H. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS ONE. 2011;6:e16350 pubmed publisher
    The dopamine transporter (DAT), a member of the neurotransmitter:Na(+) symporter (NSS) family, terminates dopaminergic neurotransmission and is a major molecular target for psychostimulants such as cocaine and amphetamine, and for the ..
  66. Karwautz A, Campos de Sousa S, Konrad A, Zesch H, Wagner G, Zormann A, et al. Family-based association analysis of functional VNTR polymorphisms in the dopamine transporter gene in migraine with and without aura. J Neural Transm (Vienna). 2008;115:91-5 pubmed
    ..We examined three VNTR polymorphisms in the dopamine transporter, the 5'UTR VNTR, the intron 8 VNTR and the intron 14 VNTR, in a sample of 205 family trios...
  67. Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, et al. Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I. J Nucl Med. 2012;53:1065-73 pubmed publisher
    ..18)F-FE-PE2I) is a new PET radioligand with a high affinity and selectivity for the dopamine transporter (DAT)...
  68. Huang X, Zhan C. How dopamine transporter interacts with dopamine: insights from molecular modeling and simulation. Biophys J. 2007;93:3627-39 pubmed
    ..and molecular dynamics simulations, we have developed three-dimensional (3D) structural models of both dopamine transporter and dopamine transporter-dopamine complex in the environment of lipid bilayer and solvent water...
  69. Kurian M, Zhen J, Cheng S, Li Y, Mordekar S, Jardine P, et al. Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. J Clin Invest. 2009;119:1595-603 pubmed publisher
    Genetic variants of the SLC6A3 gene that encodes the human dopamine transporter (DAT) have been linked to a variety of neuropsychiatric disorders, particularly attention deficit hyperactivity disorder...