DNTT

Summary

Gene Symbol: DNTT
Description: DNA nucleotidylexotransferase
Alias: TDT, DNA nucleotidylexotransferase, nucleosidetriphosphate:DNA deoxynucleotidylexotransferase, terminal addition enzyme, terminal deoxynucleotidyltransferase, terminal deoxyribonucleotidyltransferase, terminal transferase
Species: human
Products:     DNTT

Top Publications

  1. Xiong Y, Chen H, Lin P, Wang A, Wang L, Jin Y. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. Am J Physiol Cell Physiol. 2017;312:C341-C353 pubmed publisher
    ..immunohistochemical staining, real-time quantitative PCR, Western blotting, flow cytometry, terminal deoxynucleotidyltransferase-mediated deoxy-UTP nick end labeling (TUNEL) assay, and ELISA...
  2. Aras D, Cinar O, Cakar Z, Ozkavukcu S, Can A. Can dicoumarol be used as a gonad-safe anticancer agent: an in vitro and in vivo experimental study. Mol Hum Reprod. 2016;22:57-67 pubmed publisher
    ..b>Terminal deoxynucleotidyltransferase-mediated dUTP nick-end labelling (TUNEL) and Annexin-V immunofluorescence were assessed by 3D ..
  3. Wan Y, Kang G, Sreenivasan C, Daharsh L, Zhang J, Fan W, et al. A DNA Vaccine Expressing Consensus Hemagglutinin-Esterase Fusion Protein Protected Guinea Pigs from Infection by Two Lineages of Influenza D Virus. J Virol. 2018;92: pubmed publisher
    ..Using a TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling) assay, we found that IDV D/OK and D/600 infections induced ..
  4. Zhang Y, Guo K, Ji S, Liu X, Wang P, Wu J, et al. Development and characterization of a novel long-acting recombinant follicle stimulating hormone agonist by fusing Fc to an FSH-β subunit. Hum Reprod. 2016;31:169-82 pubmed publisher
    ..E2) analysis, and the ovaries were processed for hematoxylin and eosin (HE) staining, immunohistochemistry (IHC), TdT (terminal deoxynucleotidyl transferase)-mediated dUDP nick-end labeling (TUNEL), RT-PCR and western blot...
  5. Talib W. Regressions of Breast Carcinoma Syngraft Following Treatment with Piperine in Combination with Thymoquinone. Sci Pharm. 2017;85: pubmed publisher
    ..Tumor histology was examined using the hematoxylin/eosin staining protocol. Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) colorimetric assay and caspase-3 activity assays were used to detect apoptosis...
  6. Kumar A, Das S, Purkait B, Sardar A, Ghosh A, Dikhit M, et al. Ascorbate peroxidase, a key molecule regulating amphotericin B resistance in clinical isolates of Leishmania donovani. Antimicrob Agents Chemother. 2014;58:6172-84 pubmed publisher
    ..and caspase-like proteins and causing concomitant nuclear alterations, as determined by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) and DNA fragmentation in the resistant strain...
  7. Wicha P, Tocharus J, Janyou A, Jittiwat J, Changtam C, Suksamrarn A, et al. Hexahydrocurcumin protects against cerebral ischemia/reperfusion injury, attenuates inflammation, and improves antioxidant defenses in a rat stroke model. PLoS ONE. 2017;12:e0189211 pubmed publisher
    ..2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin and eosin (H&E) staining, and terminal deoxynucleotidyltransferase UTP nick end labeling (TUNEL) staining...
  8. Alves M, Boia R, Campos E, Martins J, Nunes S, Madeira M, et al. Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes. Mol Vis. 2018;24:353-366 pubmed
    ..Cell loss at the ganglion cell layer was assessed with terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) assay and by evaluating the immunoreactivity of the Brn3a transcription factor...
  9. Chen X, Chen H, Liu Y, Zhang Z, Zheng Y, Su Z, et al. The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats. Exp Biol Med (Maywood). 2016;241:193-204 pubmed publisher
    ..transcription polymerase chain reaction for cyclooxygenase-1 and cyclooxygenase-2, as well as terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling assay, immunohistochemistry for heat-shock protein 70, B-cell ..

More Information

Publications146 found, 100 shown here

  1. Hasky N, Uri Belapolsky S, Goldberg K, Miller I, Grossman H, Stemmer S, et al. Gonadotrophin-releasing hormone agonists for fertility preservation: unraveling the enigma?. Hum Reprod. 2015;30:1089-101 pubmed publisher
    ..Ovarian GnRH receptor (GnRHR), AMH and CD34 were visualized by IHC, and apoptosis was evaluated using TdT (terminal deoxynucleotidyl transferase)-mediated dUDP nick-end labeling (TUNEL)...
  2. Gao Y, Fang X, Vincent D, Threadgill D, Bartholin L, Li Q. Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling. Reprod Biol Endocrinol. 2017;15:94 pubmed publisher
    ..Terminal deoxynucleotidyl transferase (TdT) labeling of 3'-OH ends of DNA fragments, real-time PCR, and western blotting were used to examine apoptosis, ..
  3. Li Y, Hou D, Chen X, Zhu J, Zhang R, Sun W, et al. Hydralazine protects against renal ischemia-reperfusion injury in rats. Eur J Pharmacol. 2019;843:199-209 pubmed publisher
    ..Apoptosis was evaluated by terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL) staining...
  4. Proença Módena J, Hyde J, Sesti Costa R, Lucas T, Pinto A, Richner J, et al. Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System. J Virol. 2016;90:189-205 pubmed publisher
    ..The clinical signs in OROV-infected Irf5(-/-) mice were associated with abundant viral antigen and terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells in several regions of the brain...
  5. Tang Y, Cai Q, Wang Y, Fan S, Zhang Z, Xiao M, et al. Protective effect of autophagy on endoplasmic reticulum stress induced apoptosis of alveolar epithelial cells in rat models of COPD. Biosci Rep. 2017;37: pubmed publisher
    ..The cell apoptotic rates of AECs were analyzed by terminal deoxynucleotidyl transferase (TdT) mediated dUTP-biotin nick end-labeling (TUNEL) staining...
  6. Yeh C, Chang J, Yang W, Chang H, Lai E, Kuo M. NADPH oxidase 4 is involved in the triethylene glycol dimethacrylate-induced reactive oxygen species and apoptosis in human embryonic palatal mesenchymal and dental pulp cells. Clin Oral Investig. 2015;19:1463-71 pubmed publisher
    ..Apoptotic cells were evaluated using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling assay and visualized by fluorescence microscopy...
  7. Jiang H, Gao X, Gong J, Yang Q, Lan R, Wang T, et al. Downregulated Expression of Solute Carrier Family 26 Member 6 in NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative Stress. Oxid Med Cell Longev. 2018;2018:1724648 pubmed publisher
    ..5% ammonium chloride (NH4Cl) for 2 weeks. Dihydroethidium (DHE), terminal deoxynucleotidyl transferase (TdT) deoxyuridine dUTP nick-end labeling (TUNEL), and von Kossa staining were performed, and nuclear factor κB (..
  8. Ghosh T, SRIVASTAVA S, Gaurav A, Kumar A, Kumar P, Yadav A, et al. A Combination of Linalool, Vitamin C, and Copper Synergistically Triggers Reactive Oxygen Species and DNA Damage and Inhibits Salmonella enterica subsp. enterica Serovar Typhi and Vibrio fluvialis. Appl Environ Microbiol. 2019;85: pubmed publisher
    ..Reactive oxygen species (ROS) measurements with the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling assay and scanning electron microscopy imaging strongly ..
  9. Cai F, Bian Y, Wu R, Sun Y, Chen X, Yang M, et al. Yinchenhao decoction suppresses rat liver fibrosis involved in an apoptosis regulation mechanism based on network pharmacology and transcriptomic analysis. Biomed Pharmacother. 2019;114:108863 pubmed publisher
    ..Further, experimental validation was done by using terminal deoxynucleotidyl transferase (TDT) dUTP nick end labelling (TUNEL) assay and western blotting in dimethylnitrosamine (DMN)-induced liver fibrosis ..
  10. Winokur P, Subramanian P, Bullock J, Arocas V, Becerra S. Comparison of two neurotrophic serpins reveals a small fragment with cell survival activity. Mol Vis. 2017;23:372-384 pubmed
    ..serum-starved, rat-derived retinal precursor (R28) cells was assessed with terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) cell death assays. Bcl2 levels were measured with RT-PCR...
  11. Mavuluri J, Beesetti S, Surabhi R, Kremerskothen J, Venkatraman G, Rayala S. Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Mol Cell Biol. 2016;36:1354-65 pubmed publisher
    ..assays such as the γ-H2AX assay, pulsed-field gel electrophoresis (PFGE), Comet assay, terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) assay, and clonogenic cell survival assay using ..
  12. Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, et al. Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis. Molecules. 2014;19:11816-32 pubmed publisher
    ..DNA and mitochondrial damage caused by H2O2 based on single cell gel electrophoresis, in situ terminal deoxynucleotidyltransferase dUTP nick end labeling (TUNEL), flow cytometry and transmission electron microscope (TEM) assays...
  13. Razzaque M, Xu X, Han M, Badami A, Akhter S. Inhibition of Postinfarction Ventricular Remodeling by High Molecular Weight Polyethylene Glycol. J Surg Res. 2018;232:171-178 pubmed publisher
    ..PEG inhibited apoptosis as measured by terminal deoxynucleotidyl transferase [TdT]-mediated dUTP nick-end labeling positive nuclei and caspase-3 activity...
  14. Elbaz M, Yanay N, Laban S, Rabie M, Mitrani Rosenbaum S, Nevo Y. Life or death by NFκB, Losartan promotes survival in dy2J/dy2J mouse of MDC1A. Cell Death Dis. 2015;6:e1690 pubmed publisher
    ..Muscle apoptosis reduction was further confirmed using terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) assay...
  15. Xu W, Gao L, Li T, Zheng J, Shao A, Zhang J. Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-mediated Apoptosis and Blood-Brain Barrier Disruption: Possible Involvement of ATF6/CHOP Pathway. Neuroscience. 2018;388:284-296 pubmed publisher
    ..Neuronal apoptosis was assessed with Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and caspase-3 staining...
  16. Koyama Y, Kaidzu S, Kim Y, Matsuoka Y, Ishihara T, Ohira A, et al. Suppression of Light-Induced Retinal Degeneration by Quercetin via the AP-1 Pathway in Rats. Antioxidants (Basel). 2019;8: pubmed publisher
    ..of the rod outer segments and retinal pigment epithelium, and terminal deoxynucleotidyl transferase (TdT)-mediated 2'-Deoxyuridine-5'-triphosphate (dUTP) nick end labeling...
  17. Yuksel M, Yildar M, Basbug M, Cavdar F, Cikman O, Akşit H, et al. Does protocatechuic acid, a natural antioxidant, reduce renal ischemia reperfusion injury in rats?. Ulus Travma Acil Cerrahi Derg. 2017;23:1-6 pubmed publisher
    ..Kidney tissue samples were examined and scored histopathologically. Terminal deoxynucleotidyltransferase-mediated dUTP digoxigenin nick end labeling assay method was used to detect apoptotic cells...
  18. Chang J, Choi J, Rah Y, Yoo M, Oh K, Im G, et al. Sodium Selenite Acts as an Otoprotectant against Neomycin-Induced Hair Cell Damage in a Zebrafish Model. PLoS ONE. 2016;11:e0151557 pubmed publisher
    ..Apoptosis and hair cell damage of neuromasts were evaluated using the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) assay and 2-[4-(dimethylamino) styryl]-N-ethylpyridinium iodide (..
  19. Guo S, Zhen Y, Wang A. Transplantation of bone mesenchymal stem cells promotes angiogenesis and improves neurological function after traumatic brain injury in mouse. Neuropsychiatr Dis Treat. 2017;13:2757-2765 pubmed publisher
    ..sacrificed 14 days after TBI, and then brain sections were stained by terminal deoxyribonucleotidyl transferase (TDT)-mediated dUTP-digoxigenin nick end labeling staining to assess brain neuronal apoptosis...
  20. Nogami Hara A, Nagao M, Takasaki K, Egashira N, Fujikawa R, Kubota K, et al. The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia. J Ethnopharmacol. 2018;214:190-196 pubmed publisher
    ..Apoptosis was determined by terminal deoxynucleotidyl transferase (TdT)-mediated fluorescein-deoxyuridine triphosphate (dUTP) nick-end labeling...
  21. Wang E, Han Y, Jia X. PAFR-deficiency alleviates myocardial ischemia/reperfusion injury in mice via suppressing inflammation, oxidative stress and apoptosis. Biochem Biophys Res Commun. 2018;495:2475-2481 pubmed publisher
    ..PAFR-deficiency impeded apoptosis, which was proved by the decreasing in terminal deoxynucleotidyl transferase (TdT)-mediated dNTP nick end labeling (TUNEL)-positive myocytes, and Caspase-3 cleavage...
  22. Song Q, Shi Z, Bi W, Liu R, Zhang C, Wang K, et al. Beneficial effect of grape seed proanthocyanidin extract in rabbits with steroid-induced osteonecrosis via protecting against oxidative stress and apoptosis. J Orthop Sci. 2015;20:196-204 pubmed publisher
    ..Apoptosis was detected via quantitative terminal deoxynucleotidyl transferase (TdT) deoxyuridine triphosphate nick end labelling (TUNEL) staining and activated caspase 3 immunoblotting and activity...
  23. Du Z, Yang Q, Liu L, Li S, Zhao J, Hu J, et al. NADPH oxidase 2-dependent oxidative stress, mitochondrial damage and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging rats. Neuroscience. 2015;286:281-92 pubmed publisher
    ..In addition, we also found that the terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick-end-labeling (TUNEL)-positive cells in the VCN were increased in D-..
  24. Lee H, Shin S, Choo G, Kim H, Park Y, Park B, et al. Anticancer effects of Ixeris dentata (Thunb. ex Thunb.) nakai extract on human melanoma cells A375P and A375SM. J Ethnopharmacol. 2016;194:1022-1031 pubmed publisher
    ..were evaluated by measuring the tumor volume and weight and performing Terminal deoxynucleotidyl transferase (TdT) dUTP Nick End Labeling (TUNEL) assay and immunohistochemistry (IHC) in tumor xenograft models...
  25. Fang B, Li X, Bao N, Tan W, Chen F, Pi X, et al. Role of autophagy in the bimodal stage after spinal cord ischemia reperfusion injury in rats. Neuroscience. 2016;328:107-16 pubmed publisher
    ..motor neurons, and B-cell lymphoma-2 (Bcl-2) expression, and increase in the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells, Bcl-2-associated X protein (Bax), tumor necrosis ..
  26. Liu D, Bao F. Hydrogen peroxide administered into the rat spinal cord at the level elevated by contusion spinal cord injury oxidizes proteins, DNA and membrane phospholipids, and induces cell death: attenuation by a metalloporphyrin. Neuroscience. 2015;285:81-96 pubmed publisher
    ..H2O2 also significantly increased cell loss and the numbers of terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate-(dUTP)-biotin nick end labeling (TUNEL)-positive and active caspase-3-positive ..
  27. Wu Y, Ma C, Zhao H, Zhou Y, Chen Z, Wang L. Alleviation of endoplasmic reticulum stress protects against cisplatin-induced ovarian damage. Reprod Biol Endocrinol. 2018;16:85 pubmed publisher
    ..Alleviation of ERS with 4-PBA, but not of autophagy with 3-MA, protect against CDDP-induced granulosa cell apoptosis and ovarian damage. Thus, 4-PBA can be used to protect the ovary during chemotherapy in women. ..
  28. Micillo A, Vassallo M, Cordeschi G, D Andrea S, Necozione S, Francavilla F, et al. Semen leukocytes and oxidative-dependent DNA damage of spermatozoa in male partners of subfertile couples with no symptoms of genital tract infection. Andrology. 2016;4:808-15 pubmed publisher
    ..8-OHdG) expression identified spermatozoa with DNA oxidative adducts while terminal deoxynucleotidyl transferase (TdT)-mediated fluorescein-dUTP nick end labeling (TUNEL) assay detected spermatozoa with DNA fragmentation...
  29. Cahill E, Kennelly H, Carty F, Mahon B, English K. Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis. Stem Cells Transl Med. 2016;5:1307-1318 pubmed
    ..Terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling assay was performed on ex vivo lung sections to examine the effects of MSC on apoptosis...
  30. Zhang X, Zhang H, Gao Q, Ji S, Bing L, Hao J. Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway. Reprod Biomed Online. 2015;30:514-21 pubmed publisher
    ..b>TdT (terminal deoxynucleotidyl transferase)-mediated dUDP nick-end labelling assay was carried out to detect the oocyte ..
  31. Zhao Y, Du J, Chen Y, Tang Y, Qin G, Lv G, et al. Inhibition of Oct 3/4 mitigates the cardiac progenitor-derived myocardial repair in infarcted myocardium. Stem Cell Res Ther. 2015;6:259 pubmed publisher
    ..b>Terminal deoxynucleotidyltransferase (TdT) nick-end labeling (TUNEL) was carried out to assess apoptotic cardiomyocytes...
  32. Ya B, Li H, Wang H, Wu F, Xin Q, Cheng H, et al. 5-HMF attenuates striatum oxidative damage via Nrf2/ARE signaling pathway following transient global cerebral ischemia. Cell Stress Chaperones. 2017;22:55-65 pubmed publisher
    ..injury of the striatum was observed by cresyl violet staining and terminal deoxynucleotidyl transferase (TdT)-mediated dNTP nick end labeling (TUNEL) staining...
  33. Li Y, Gupta G, Molofsky A, Xie Y, Shihabi N, McCormick J, et al. B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement: Report of 3 Cases in Adult Patients. Am J Surg Pathol. 2017;: pubmed publisher
    ..However, all 3 had immature immunophenotypes including expression of terminal deoxynucleotidyl transferase (TdT), absence of BCL6, and dim-to-negative CD45. CD20 was largely negative in 2 of 3 cases...
  34. Zhao Y, Fang Y, Zhao H, Li J, Duan Y, Shi W, et al. Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice. Eur J Pharmacol. 2018;818:1-9 pubmed publisher
    ..1mg/kg) for 14 days after reperfusion. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) was used to detect apoptotic cells in penumbral tissue...
  35. Fujita K, Shimazaki N, Ohta Y, Kubota T, Ibe S, Toji S, et al. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. Genes Cells. 2003;8:559-71 pubmed
    b>Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase that enhances the Ig and TcR gene diversity in the N region at the junctions of variable (V), diversity (D) and joining (J) segments in B- and T-cells...
  36. Yi M, Zhang Y, Wang Y, Su N, Liu S. Association between the polymorphism of C861G (rs6296) in the serotonin 1B receptor gene and Tourette syndrome in Han Chinese people. Asia Pac Psychiatry. 2017;9: pubmed publisher
    ..over-transmission of the G861 allele in HTR1B to TS offspring using the transmission disequilibrium test (TDT), haplotype relative risk (HRR) and haplotype-based HRR (HHRR) (TDT χ2  = 0...
  37. Zhao S, Tong W. [Role of transanal drainage tube in the prevention of anastomotic leakage after anterior resection for rectal cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2016;19:714-7 pubmed
    ..The transanal drainage tube (TDT) after anastomosis is gradually proved to be useful in prevention of AL...
  38. Liang Y, Huang M, Jiang X, Liu Q, Chang X, Guo Y. The neuroprotective effects of Berberine against amyloid ?-protein-induced apoptosis in primary cultured hippocampal neurons via mitochondria-related caspase pathway. Neurosci Lett. 2017;655:46-53 pubmed publisher
    ..b>TdT-mediated dUTP nick-end labeling, MTT, Propidium iodide, MMP, Caspase activity measurement, Western blot...
  39. Zhang C, Zou Y, Ma J, Dang X, Wang K. Apoptosis associated with Wnt/β-catenin pathway leads to steroid-induced avascular necrosis of femoral head. BMC Musculoskelet Disord. 2015;16:132 pubmed publisher
    ..Apoptosis was detected via quantitative terminal deoxynucleotidyl transferase (TdT) deoxyuridine triphosphate nick-end labelling (TUNEL) staining, caspase-3 activity assay, and detection of Bcl-2 ..
  40. Zhao Q, Che X, Zhang H, Tan G, Liu L, Jiang D, et al. Thioredoxin-Interacting Protein Mediates Apoptosis in Early Brain Injury after Subarachnoid Haemorrhage. Int J Mol Sci. 2017;18: pubmed publisher
    ..By using adult male Sprague-Dawley rats to establish SAH models, as well as Terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) staining, immunofluorescence, and western blot, we found that TXNIP ..
  41. Kawada K, Takahashi R, Hida K, Sakai Y. Impact of transanal drainage tube on anastomotic leakage after laparoscopic low anterior resection. Int J Colorectal Dis. 2018;33:337-340 pubmed publisher
    Although a few reports have suggested transanal drainage tube (TDT) can reduce the pressure in the anastomotic portion, it remains unclear whether TDT can prevent anastomotic leakage (AL)...
  42. Griffin H, Hall D, Topf A, Eden J, Stuart A, Parsons J, et al. Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation. PLoS ONE. 2009;4:e4978 pubmed publisher
    ..genotyped 771 CVM cases, of whom 595 had the outflow tract malformation Tetralogy of Fallot (TOF), and carried out TDT and case-control analyses using haplotype-tagging SNPs in VEGF...
  43. Wang Z, Medrzycki M, Bunting S, Bunting K. Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis. Oncotarget. 2015;6:28961-72 pubmed publisher
    ..regulating genes (Tie2, Mpl, Slamf1, Spi1, Cited2) and increased expression of B-cell development genes (Satb1, Dntt, Btla, Flk2)...
  44. Zhang C, Qu B, Ye P, Li J, Bao C. Vulnerability of atherosclerotic plaques is associated with type I interferon in a murine model of lupus and atherosclerosis. Genet Mol Res. 2015;14:14871-81 pubmed publisher
    ..Cell apoptosis was detected by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick-end labeling. Gene expression was determined by real-time PCR analyses...
  45. Wigmann Ã, Moreira R, Alvarenga V, Sant Ana A, Copetti M. Survival of Penicillium spp. conidia during deep-frying and baking steps of frozen chicken nuggets processing. Food Microbiol. 2016;55:1-6 pubmed publisher
    ..2 in thermal death tubes (TDT) at 80 °C/30 min...
  46. Lee S, Jo K. Visualization of Surface-tethered Large DNA Molecules with a Fluorescent Protein DNA Binding Peptide. J Vis Exp. 2016;: pubmed publisher
    ..The blunt ended DNA is tagged with biotinylated dUTP at its 3' hydroxyl terminus, by terminal transferase, while the sticky ended DNA is hybridized with biotinylated complimentary oligonucleotides by DNA ligase...
  47. Jayesh P, Vrinda S, Priyaja P, Philip R, Singh I. Impaired telomerase activity hinders proliferation and in vitro transformation of Penaeus monodon lymphoid cells. Cytotechnology. 2016;68:1301-14 pubmed publisher
    Retaining terminal transferase activity of telomerase, the ribonucleoprotein enzyme which add telomeric repeats on chromosome end is thought to be required to prevent cellular ageing...
  48. Zou J, Feng H, Sood R, Kinnunen P, Pyykko I. Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration. Nanoscale Res Lett. 2017;12:372 pubmed publisher
    ..The potential apoptosis was analyzed using terminal transferase (TdT) to label the free 3'OH breaks in the DNA strands of apoptotic cells with TMR-dUTP (TUNEL staining)...
  49. Zhang J, Lei L, Shang J, Huo T, Zhang B, Chen G, et al. Local application of paeonol prevents early restenosis: a study with a rabbit vein graft model. J Surg Res. 2017;212:278-287 pubmed publisher
    ..VECs apoptosis was also detected with terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling assay...
  50. Wu H, Wang K, Liu W, Hao Q. Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo. Genet Mol Res. 2015;14:6591-7 pubmed publisher
    ..ovarian cancer cells were examined using the 3(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) and TdT-mediated dUTP nick-end labeling (TUNEL) assays in vitro...
  51. Blevins T, Podicheti R, Mishra V, Marasco M, Wang J, Rusch D, et al. Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis. elife. 2015;4:e09591 pubmed publisher
    ..RDR2 terminal transferase activity, also demonstrated in vitro, may account for occasional non-templated nucleotides at P4R2 RNA 3' ..
  52. Ding J, Zhao Z, Wang C, Wang C, Li P, Qian C, et al. Bioluminescence imaging of transplanted human endothelial colony-forming cells in an ischemic mouse model. Brain Res. 2016;1642:209-218 pubmed publisher
    ..and histological analysis of brain slices with CD31 immunostaining in brain tissue, double cortin analysis, and the TdT-mediated dUTP nick end labeling (TUNEL) assay, we demonstrated functional restoration, improved angiogenesis, ..
  53. Xue L, Yang Y, Zhang Z, Zhang J, Gao L, Bin H, et al. Naphthalenediimide-alt-Fused Thiophene D-A Copolymers for the Application as Acceptor in All-Polymer Solar Cells. Chem Asian J. 2016;11:2785-2791 pubmed publisher
    ..including thiophene (P(NDI-T)), thieno[3,2-b]thiophene (P(NDI-TT)), and thieno[3,2-b;4,5-b]dithiophene (P(NDI-TDT)), were synthesized, for the application as acceptor materials in all-polymer solar cells (all-PSCs)...
  54. Matsuda A, Miyashita M, Matsumoto S, Sakurazawa N, Takahashi G, Matsutani T, et al. Comparison between metallic stent and transanal decompression tube for malignant large-bowel obstruction. J Surg Res. 2016;205:474-481 pubmed publisher
    ..was to compare short-term outcomes of endoscopic decompression using a SEMS versus a transanal decompression tube (TDT)...
  55. Yi J, Qu H, Wu Y, Wang Z, Wang L. Study on antitumor, antioxidant and immunoregulatory activities of the purified polyphenols from pinecone of Pinus koraiensis on tumor-bearing S180 mice in vivo. Int J Biol Macromol. 2017;94:735-744 pubmed publisher
    ..Moreover, TdT-mediated dUTP nick end labeling (TUNEL) assay results further confirmed the apoptosis of S180 tumor cells...
  56. Shigeta K, Okabayashi K, Baba H, Hasegawa H, Tsuruta M, Yamafuji K, et al. A meta-analysis of the use of a transanal drainage tube to prevent anastomotic leakage after anterior resection by double-stapling technique for rectal cancer. Surg Endosc. 2016;30:543-550 pubmed publisher
    The safety and efficacy of transanal drainage tube (TDT) placement to decrease the risk of postoperative anastomotic leakage after rectal cancer surgery has not been validated...
  57. Wang P, Wan Y, Deng S, Yang S, Su Y, Fan C, et al. Aptamer-initiated on-particle template-independent enzymatic polymerization (aptamer-OTEP) for electrochemical analysis of tumor biomarkers. Biosens Bioelectron. 2016;86:536-541 pubmed publisher
    ..Then terminal deoxynucleotidyl transferase (TdT) is employed to catalyze the incorporation of biotin labeled dNTPs into the 3'-OH terminals of the DNA aptamer on ..
  58. Liu Y, Xiong E, Li X, Li J, Zhang X, Chen J. Sensitive electrochemical assay of alkaline phosphatase activity based on TdT-mediated hemin/G-quadruplex DNAzyme nanowires for signal amplification. Biosens Bioelectron. 2017;87:970-975 pubmed publisher
    Taking TdT-mediated hemin/G-quadruplex DNAzyme nanowires as NADH oxidase and HRP-mimicking DNAzyme, a novel DNA-based electrochemical method has been developed for sensitive and selective assay of alkaline phosphatase (AP) activity...
  59. Jia Z, He S, Jiang S, Zhang B, Duan S, Shi J, et al. Rs12941170 at SOX9 gene associated with orofacial clefts in Chinese. Arch Oral Biol. 2017;76:14-19 pubmed publisher
    ..Allelic TDT results showed that G allele at rs12941170 of SOX9 was under-transmitted among NSOCs (p=0.00014, OR=0...
  60. Nam Y, Le H, Rodriguez I, Kim E, Kim K, Jeong S, et al. Enhanced antidiabetic efficacy and safety of compound K⁄β-cyclodextrin inclusion complex in zebrafish. J Ginseng Res. 2017;41:103-112 pubmed publisher
    ..we confirmed the toxicity of CD-CK relative to CK alone by morphological changes, mitochondrial damage, and TdT-UTP nick end labeling (TUNEL) assays, and determined the ratio between the toxic and therapeutic dose for both ..
  61. Morishita M, Endo T, Baba T, Kuno Y, Ikeda K, Kiya T, et al. Pioglitazone is effective for multiple phenotyepes of the Zucker fa/fa rat with polycystc ovary morphology and insulin resistance. J Ovarian Res. 2018;11:24 pubmed publisher
    ..histology to check follicle numbers by using hematoxylin-eosin staining, and the number of atretic follicles using Tdt-mediated dUTP nick end labeling (TUNEL) methods...
  62. Abad Grau M, Medina Medina N, Montes Soldado R, Matesanz F, Bafna V. Sample reproducibility of genetic association using different multimarker TDTs in genome-wide association studies: characterization and a new approach. PLoS ONE. 2012;7:e29613 pubmed publisher
    ..As a test exhibiting this feature to its maximum, we introduce the multimarker 2-Groups TDT (mTDT(2G)), a test which under the hypothesis of no linkage, asymptotically follows a χ2 distribution with 1 ..
  63. Jung S, Lee A, Park J, Baek S, Kim Y. Investigation of Parental Transmission of RUNX2 Single Nucleotide Polymorphism and Its Association With Nonsyndromic Cleft Lip With or Without Palate. Cleft Palate Craniofac J. 2014;51:234-9 pubmed publisher
    ..The family-based TDT showed significant evidence of linkage and association at rs1934328 (P = .001)...
  64. Deng Y, Guo X, Yuan X, Shang J, Zhu D, Liu H. P2X7 Receptor Antagonism Attenuates the Intermittent Hypoxia-induced Spatial Deficits in a Murine Model of Sleep Apnea Via Inhibiting Neuroinflammation and Oxidative Stress. Chin Med J (Engl). 2015;128:2168-75 pubmed publisher
    ..Cell damage was evaluated by Hematoxylin and Eosin staining and Terminal Transferase dUTP Nick-end Labeling method...
  65. Wang F, Huang J, Lv Y, Ma X, Yang B, Wang E, et al. Predicting perceptual learning from higher-order cortical processing. Neuroimage. 2016;124:682-692 pubmed publisher
    ..electroencephalography (EEG) from human adults over the course of learning in a texture discrimination task (TDT)...
  66. Connor A, Kelley P, Tempero R. Invariant asymmetry renews the lymphatic vasculature during homeostasis. J Transl Med. 2016;14:209 pubmed publisher
    ..Inductive genetic techniques were used to label LECs with tandem dimer tomato (tdT) in adult mice...
  67. Xie H, Wang Q, Chai Y, Yuan Y, Yuan R. Enzyme-assisted cycling amplification and DNA-templated in-situ deposition of silver nanoparticles for the sensitive electrochemical detection of Hg(2.). Biosens Bioelectron. 2016;86:630-635 pubmed publisher
    ..ions (Hg(2+)) based on in-situ deposition of silver nanoparticles (AgNPs) on terminal deoxynucleotidyl transferase (TdT) extended ssDNA for signal output and nicking endonuclease for cycling amplification...
  68. Li X, Lin W, Wang J, Zhang W, Yin A, Huang Y, et al. Dec1 expression predicts prognosis and the response to temozolomide chemotherapy in patients with glioma. Mol Med Rep. 2016;14:5626-5636 pubmed publisher
    ..Dec1 expression was also compared with the apoptosis index determined by TdT‑mediated dUTP nick ending‑labeling assay in recurrent glioblastomas...
  69. Xia X. Phenotypic Analysis and Molecular Markers of Plant Nodule Senescence. Methods Mol Biol. 2018;1744:65-80 pubmed publisher
    ..rhizobium inoculation, nitrogenase activity determination with the acetylene reduction assay, leghemoglobin content determination, and apoptotic cell identification with TdT-mediated dUTP-biotin nick end-labeling (TUNEL) staining.
  70. Zhang Y, Wang X, Zhang Q, Zhang C. Label-Free Sensitive Detection of DNA Methyltransferase by Target-Induced Hyperbranched Amplification with Zero Background Signal. Anal Chem. 2017;89:12408-12415 pubmed publisher
    ..to sensitively detect DNA adenine methyltransferase (Dam) on the basis of terminal deoxynucleotidyl transferase (TdT)-activated Endonuclease IV (Endo IV)-assisted hyperbranched amplification...
  71. Ichikawa K, Noguchi M, Imai H, Sekiguchi Y, Wakabayashi M, Sawada T, et al. A case of T cell prolymphocytic leukemia involving blast transformation. Int J Hematol. 2011;93:667-672 pubmed publisher
    ..and cytoplasmic CD3, but negative for surface CD3 and CD8 and cytoplasmic terminal deoxynucleotidyl transferase (TdT). The T cell receptor (TCR) C?1 gene was rearranged in the cells...
  72. Che F, Zhang Y, Wang G, Heng X, Liu S, Du Y. The role of GRIN2B in Tourette syndrome: Results from a transmission disequilibrium study. J Affect Disord. 2015;187:62-5 pubmed publisher
    ..Haplotype relative risk (HRR), transmission disequilibrium test (TDT) and Haplotype-based haplotype relative risk (HHRR) analyses were performed on the genotype data...
  73. Slot L, Hoogeboom R, Smit L, Wormhoudt T, Biemond B, Oud M, et al. B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains. Am J Pathol. 2016;186:3273-3284 pubmed publisher
    ..We describe four extraordinary cases of FL, which progressed to TdT+CD20- precursor B-lymphoblastic lymphoma (B-LBL)...
  74. Luo L, Xu F, Shi H, He X, Qing T, Lei Y, et al. Label-free and sensitive assay for deoxyribonuclease I activity based on enzymatically-polymerized superlong poly(thymine)-hosted fluorescent copper nanoparticles. Talanta. 2017;169:57-63 pubmed publisher
    ..Herein, by effectively combining the special functions of DNase I and terminal deoxynucleotidyl transferase (TdT), a simple, green, cost-effective, label-free and ultrasensitive assay for DNase I activity has been constructed ..
  75. Zhao H, Darzynkiewicz Z. Rapid Detection of DNA Strand Breaks in Apoptotic Cells by Flow- and Image-Cytometry. Methods Mol Biol. 2017;1644:139-149 pubmed publisher
    ..of the widely used TUNEL methodology that is based on the use of exogenous terminal deoxynucleotidyl transferase (TdT) to label 3'OH ends in DSBs with fluorochromes...
  76. Jin Y, Peng L, Zhao A. Hyperoxia induces the apoptosis of alveolar epithelial cells and changes of pulmonary surfactant proteins. Eur Rev Med Pharmacol Sci. 2018;22:492-497 pubmed publisher
    ..and recorded pathologic changes of lung tissue and detected apoptosis rate of alveolar epithelial cells by TUNEL (TdT-mediated dUTP nick end labeling)...
  77. Chang L, Bollum F. Molecular biology of terminal transferase. CRC Crit Rev Biochem. 1986;21:27-52 pubmed
    b>Terminal transferase is an unusual deoxynucleotide polymerizing enzyme found only in prelymphocytes. The protein was purified to homogeneity from calf thymus glands in 1971 as a 32 kDa protein with a two peptide structure...
  78. Kapelski P, Skibinska M, Maciukiewicz M, Pawlak J, Zaremba D, Twarowska Hauser J. Family-based association study of interleukin 10 (IL10) and interleukin 10 receptor alpha (IL10RA) functional polymorphisms in schizophrenia in Polish population. J Neuroimmunol. 2016;297:92-7 pubmed publisher
    ..The aim of this study was to perform a transmission disequilibrium test (TDT) on a group of 146 schizophrenia trios from the Polish population...
  79. Soyaliç H, Gevrek F, Koc S, Avcu M, Metin M, Aladag I. Intraperitoneal curcumin and vitamin E combination for the treatment of cisplatin-induced ototoxicity in rats. Int J Pediatr Otorhinolaryngol. 2016;89:173-8 pubmed publisher
    ..Histopathological findings included a TUNEL (TdT-mediated deoxyuridine triphosphate nick end-labeling) assay, and the percentage of apoptotic cells was calculated...
  80. Dunlap J, Cascio M, Stacey X, Click S, Troxell M. TdT-positive Infiltrate in Inflamed Pediatric Kidney: A Potential Diagnostic Pitfall. Am J Surg Pathol. 2017;41:706-716 pubmed publisher
    ..Immunohistochemical analysis revealed numerous terminal deoxynucleotidyl transferase (TdT)-positive cells, which may raise concern for lymphoblastic lymphoma...
  81. Wakolbinger R, Diers M, Hruby L, Sturma A, Aszmann O. Home based Tactile Discrimination Training (TDT) reduces phantom limb pain. Pain Pract. 2017;: pubmed publisher
    ..New attempts, such as mirror therapy or electrical sensory discrimination training, make use of the brain's plasticity to alleviate this centrally derived pain...
  82. Peterson R, Cheung L, Mattaliano R, Chang L, Bollum F. Molecular cloning of human terminal deoxynucleotidyltransferase. Proc Natl Acad Sci U S A. 1984;81:4363-7 pubmed
    A cDNA of the human terminal deoxynucleotidyltransferase (TdT; "terminal transferase," EC 2.7.7.31) was isolated from a human lymphoblastoid cell cDNA library in lambda gt 11 by using immunological procedures...
  83. Doğanay G, Ekmekçi P, Kazbek B, Yilmaz H, Erkan G, Tuzuner F. Effects of alfentanil or fentanyl added to propofol for sedation in colonoscopy on cognitive functions: Randomized controlled trial. Turk J Gastroenterol. 2017;28:453-459 pubmed publisher
    ..Trieger dot test (TDT) and Digit Symbol Substitution Test (DSST) were performed post procedure...
  84. Zhang M, Wang G, Zhao D, Huang C, Cao H, Chen M. 3D hole-transporting materials based on coplanar quinolizino acridine for highly efficient perovskite solar cells. Chem Sci. 2017;8:7807-7814 pubmed publisher
    ..A cheaper Ag nanolayer was utilized to replace Au as the counter electrodes, and the title HTM TDT-OMeTAD was synthesized via an easy four-step synthesis (total yield: 61%) to achieve the low cost and ..
  85. Yang B, Gathy K, Coleman M. Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. J Biol Chem. 1994;269:11859-68 pubmed
    ..The four mutant forms of terminal transferase were also overexpressed in the baculovirus expression system and purified from Trichoplusia ni larvae by a ..
  86. Zhao E, Shen Y, Pleasance E, Kasaian K, Leelakumari S, Jones M, et al. Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer. Clin Cancer Res. 2017;23:7521-7530 pubmed publisher
    ..Clinical endpoints were overall survival (OS), total duration on platinum-based therapy (TDT), and radiographic evidence of clinical improvement (CI)...
  87. Kawachi J, Kashiwagi H, Shimoyama R, Isogai N, Fukai R, Miyake K, et al. Comparison of efficacies of the self-expandable metallic stent versus transanal drainage tube and emergency surgery for malignant left-sided colon obstruction. Asian J Surg. 2018;41:498-505 pubmed publisher
    ..Recently, self-expandable metallic stents (SEMS) and transanal decompression tubes (TDT) have become widely used decompression methods to avoid stoma surgery...
  88. Wen K, Gill R. Immature Terminal Deoxynucleotidyl Transferase Positive B Cells are Detected in a Subset of Adult and Pediatric Liver Biopsies. Appl Immunohistochem Mol Morphol. 2017;: pubmed publisher
    Terminal deoxynucleotidyl transferase (TdT) is a nuclear enzyme restricted to precursor lymphoid cells and their malignant counterparts; immunohistochemical TdT labeling is helpful in recognition of lymphoblasts, which can resemble ..
  89. Klonizakis P, Klaassen R, Sousos N, Liakos A, Tsapas A, Vlachaki E. Evaluation of the Greek TranQol: a novel questionnaire for measuring quality of life in transfusion-dependent thalassemia patients. Ann Hematol. 2017;96:1937-1944 pubmed publisher
    ..using this novel disease-specific quality of life (QoL) measure in patients with transfusion-dependent thalassemia (TDT). The TranQol and SF-36v2 questionnaires were administered to 94 adult TDT patients with a mean age of 32...
  90. Wang M, Ji Z, Wang S, Kim J, Yang H, Jiang X, et al. Mechanisms to protect the privacy of families when using the transmission disequilibrium test in genome-wide association studies. Bioinformatics. 2017;: pubmed publisher
    ..Protecting privacy in family-based studies is more difficult. The transmission disequilibrium test (TDT) is a powerful family-based association test employed in many rare disease studies...
  91. Yasuda H, Tsutsui M, Ota Y, Tanaka M, Komatsu N. Indolent T-lymphoblastic proliferation concomitant to acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review. Histopathology. 2017;: pubmed publisher
    ..a non-clonal benign condition showing extrathymic proliferation of T-lymphoblasts positive for CD3, CD4, CD8, and TdT. Isolated iT-LBP has been observed, but the majority of iT-LBP have been seen in conjunction with other disorders ..
  92. Dworzak M, Fritsch G, Froschl G, Printz D, Gadner H. Four-color flow cytometric investigation of terminal deoxynucleotidyl transferase-positive lymphoid precursors in pediatric bone marrow: CD79a expression precedes CD19 in early B-cell ontogeny. Blood. 1998;92:3203-9 pubmed
    Terminal deoxynucleotidyl transferase (TdT)-positive cells in human bone marrow (BM) are a phenotypically inhomogeneous population of precursor cells...