DNM2

Summary

Gene Symbol: DNM2
Description: dynamin 2
Alias: CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5, dynamin-2, dynamin II
Species: human
Products:     DNM2

Top Publications

  1. Pizzato M, Helander A, Popova E, Calistri A, Zamborlini A, Palu G, et al. Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc Natl Acad Sci U S A. 2007;104:6812-7 pubmed
    ..We now show that dynamin 2 (Dyn2), a key regulator of vesicular trafficking, is a binding partner of Nef that is required for its ability ..
  2. Claeys K, Zuchner S, Kennerson M, Berciano J, Garcia A, Verhoeven K, et al. Phenotypic spectrum of dynamin 2 mutations in Charcot-Marie-Tooth neuropathy. Brain. 2009;132:1741-52 pubmed publisher
    Dominant intermediate Charcot-Marie-Tooth neuropathy type B is caused by mutations in dynamin 2. We studied the clinical, haematological, electrophysiological and sural nerve biopsy findings in 34 patients belonging to six unrelated ..
  3. Ezratty E, Partridge M, Gundersen G. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat Cell Biol. 2005;7:581-90 pubmed
    ..Inhibition of dynamin prevents migration of cells with a focal adhesion phenotype. Our results show that focal adhesion disassembly involves microtubules, dynamin and FAK, and is not simply the reversal of focal adhesion formation. ..
  4. Wang Y, Cao H, Chen J, McNiven M. A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src. Mol Biol Cell. 2011;22:1529-38 pubmed publisher
    ..Using a novel antibody specific to phospho-dynamin (pDyn-Tyr-231), we found that Dyn2 is phosphorylated at FAs by Src kinase and is recruited to FAs by a direct interaction with the 4...
  5. Susman R, Quijano Roy S, Yang N, Webster R, Clarke N, Dowling J, et al. Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy. Neuromuscul Disord. 2010;20:229-37 pubmed publisher
    Mutations in dynamin-2 (DNM2) cause autosomal dominant centronuclear myopathy (CNM)...
  6. Bitoun M, Stojkovic T, Prudhon B, Maurage C, Latour P, Vermersch P, et al. A novel mutation in the dynamin 2 gene in a Charcot-Marie-Tooth type 2 patient: clinical and pathological findings. Neuromuscul Disord. 2008;18:334-8 pubmed publisher
    Mutations in dynamin 2 (DNM2) have been associated with autosomal dominant centronuclear myopathy, dominant intermediate Charcot-Marie-Tooth (CMT) type B and CMT2...
  7. Tanabe K, Takei K. Dynamic instability of microtubules requires dynamin 2 and is impaired in a Charcot-Marie-Tooth mutant. J Cell Biol. 2009;185:939-48 pubmed publisher
    ..Recently, mutations in the ubiquitously expressed dynamin 2 (dyn2) protein were found in patients with Charcot-Marie-Tooth (CMT) disease, which is an inherited peripheral ..
  8. Soulet F, Yarar D, Leonard M, Schmid S. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol Biol Cell. 2005;16:2058-67 pubmed
    ..Thus, our results establish that SNX9 is required for efficient clathrin-mediated endocytosis and suggest that it functions to regulate dynamin activity...
  9. Melberg A, Kretz C, Kalimo H, Wallgren Pettersson C, Toussaint A, Böhm J, et al. Adult course in dynamin 2 dominant centronuclear myopathy with neonatal onset. Neuromuscul Disord. 2010;20:53-6 pubmed publisher
    ..A618D, in dynamin 2 (DNM2)...

More Information

Publications80

  1. Orth J, McNiven M. Dynamin at the actin-membrane interface. Curr Opin Cell Biol. 2003;15:31-9 pubmed
    ..Recent data support the concept that the dynamin family might act as a 'polymeric contractile scaffold' at the interface between biological membranes and filamentous actin. ..
  2. Eppinga R, Krueger E, Weller S, Zhang L, Cao H, McNiven M. Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. Oncogene. 2012;31:1228-41 pubmed publisher
    ..The large GTPase Dynamin 2 (Dyn2), a Src-kinase substrate, regulates membrane-cytoskeletal dynamics although it is yet to be defined if it ..
  3. Bitoun M, Maugenre S, Jeannet P, Lacene E, Ferrer X, Laforet P, et al. Mutations in dynamin 2 cause dominant centronuclear myopathy. Nat Genet. 2005;37:1207-9 pubmed
    ..families affected by centronuclear myopathy, we identified recurrent and de novo missense mutations in the gene dynamin 2 (DNM2, 19p13...
  4. Echaniz Laguna A, Nicot A, Carré S, Franques J, Tranchant C, Dondaine N, et al. Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation. Neuromuscul Disord. 2007;17:955-9 pubmed
    Mutations in dynamin 2 (DNM2), an ubiquitously-expressed large GTPase, cause autosomal dominant centronuclear myopathy (DNM2-CNM) and AD Charcot-Marie-Tooth disease type 2B (DNM2-CMT2B)...
  5. Bitoun M, Durieux A, Prudhon B, Bevilacqua J, Herledan A, Sakanyan V, et al. Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis. Hum Mutat. 2009;30:1419-27 pubmed publisher
    b>Dynamin 2 (DNM2) is a large GTPase involved in the release of nascent vesicles during endocytosis and intracellular membrane trafficking...
  6. Kennerson M, Zhu D, Gardner R, Storey E, Merory J, Robertson S, et al. Dominant intermediate Charcot-Marie-Tooth neuropathy maps to chromosome 19p12-p13.2. Am J Hum Genet. 2001;69:883-8 pubmed
    ..Multipoint linkage analysis suggested the most likely location at D19S226 (maximum multipoint LOD score 6.77), within a 10-cM confidence interval. This study establishes the presence of a locus for DI-CMT on chromosome 19p12-p13.2. ..
  7. Fish K, Schmid S, Damke H. Evidence that dynamin-2 functions as a signal-transducing GTPase. J Cell Biol. 2000;150:145-54 pubmed
    ..Here, we present new evidence that the ubiquitously expressed isoform dynamin-2 (dyn2) can also function in a signal transduction pathway(s)...
  8. Wang Z, Humphrey C, Frilot N, Wang G, Nie Z, Moniri N, et al. Dynamin2- and endothelial nitric oxide synthase-regulated invasion of bladder epithelial cells by uropathogenic Escherichia coli. J Cell Biol. 2011;192:101-10 pubmed publisher
    ..coli invasion. These findings suggest that UPEC escape urinary flushing and immune cell surveillance by means of eNOS-dependent dynamin2 S-nitrosylation and invasion of host cells to cause recurrent UTIs. ..
  9. Diatloff Zito C, Gordon A, Duchaud E, Merlin G. Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family. Gene. 1995;163:301-6 pubmed
    ..The sequence reported here should allow a more complete analysis of Dyn function(s) in man. ..
  10. Pizzato M, Popova E, Gottlinger H. Nef can enhance the infectivity of receptor-pseudotyped human immunodeficiency virus type 1 particles. J Virol. 2008;82:10811-9 pubmed publisher
    ..Furthermore, since the infectivity of Tva pseudotypes was blocked by inhibitors of endosomal acidification, we conclude that low-pH-dependent entry does not always bypass the requirement for Nef. ..
  11. Bitoun M, Bevilacqua J, Prudhon B, Maugenre S, Taratuto A, Monges S, et al. Dynamin 2 mutations cause sporadic centronuclear myopathy with neonatal onset. Ann Neurol. 2007;62:666-70 pubmed
    We report four heterozygous dynamin 2 (DNM2) mutations in five centronuclear myopathy patients aged 1 to 15 years. They all presented with neonatal hypotonia with weak suckling. Thereafter, their phenotype progressively improved...
  12. Mori Yoshimura M, Okuma A, Oya Y, Fujimura Kiyono C, Nakajima H, Matsuura K, et al. Clinicopathological features of centronuclear myopathy in Japanese populations harboring mutations in dynamin 2. Clin Neurol Neurosurg. 2012;114:678-83 pubmed publisher
    Missense mutations in dynamin 2 gene (DNM2) are associated with autosomal dominant centronuclear myopathy (CNM) with characteristic histopathological findings of centrally located myonuclei in a large number of muscle fibers...
  13. Hanisch F, Muller T, Dietz A, Bitoun M, Kress W, Weis J, et al. Phenotype variability and histopathological findings in centronuclear myopathy due to DNM2 mutations. J Neurol. 2011;258:1085-90 pubmed publisher
    Autosomal-dominant centronuclear myopathy (CNM) due to mutations in the dynamin 2 gene (DNM2) is a rare congenital myopathy histopathologically characterized by centrally located nuclei and a radial arrangement of sarcoplasmic strands ..
  14. Bhattacharya R, Kang Decker N, Hughes D, Mukherjee P, Shah V, McNiven M, et al. Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling. FASEB J. 2005;19:1692-4 pubmed
    ..Taken together, our findings suggest that dynamin-2 regulates KDR expression and function and hence plays an important role in VPF/VEGF mediated angiogenesis. ..
  15. Gomez T, Hamann M, McCarney S, Savoy D, Lubking C, Heldebrant M, et al. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol. 2005;6:261-70 pubmed
    ..Using small interfering RNA, we show here that dynamin 2 (Dyn2), a large GTPase involved in receptor-mediated internalization, did not alter antibody-mediated T cell ..
  16. Schafer D, Weed S, Binns D, Karginov A, Parsons J, Cooper J. Dynamin2 and cortactin regulate actin assembly and filament organization. Curr Biol. 2002;12:1852-7 pubmed
    ..GTP hydrolysis altered the organization of the filaments and the lipid vesicles. We conclude that dynamin2, through an interaction with cortactin, regulates actin assembly and actin filament organization at membranes. ..
  17. Kasai K, Shin H, Shinotsuka C, Murakami K, Nakayama K. Dynamin II is involved in endocytosis but not in the formation of transport vesicles from the trans-Golgi network. J Biochem. 1999;125:780-9 pubmed
    ..There are three dynamin genes in mammals: dynamin I is neuron-specific, dynamin II shows ubiquitous expression, and dynamin III is expressed in testis, brain, and lung...
  18. Böhm J, Biancalana V, DeChene E, Bitoun M, Pierson C, Schaefer E, et al. Mutation spectrum in the large GTPase dynamin 2, and genotype-phenotype correlation in autosomal dominant centronuclear myopathy. Hum Mutat. 2012;33:949-59 pubmed publisher
    ..Autosomal dominant CNM is due to mutations in the large GTPase dynamin 2 (DNM2), a mechanochemical enzyme regulating cytoskeleton and membrane trafficking in cells...
  19. Schroeder B, Weller S, Chen J, BILLADEAU D, McNiven M. A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding. EMBO J. 2010;29:3039-53 pubmed publisher
    ..Internalization of the EGFR requires dynamin 2 (Dyn2), a large GTPase that deforms lipid bilayers, leading to vesicle scission...
  20. Malim M, Emerman M. HIV-1 accessory proteins--ensuring viral survival in a hostile environment. Cell Host Microbe. 2008;3:388-98 pubmed publisher
    ..Broadly speaking, the HIV-1 accessory proteins modify the local environment within infected cells to ensure viral persistence, replication, dissemination, and transmission. ..
  21. Grassart A, Cheng A, Hong S, Zhang F, Zenzer N, Feng Y, et al. Actin and dynamin2 dynamics and interplay during clathrin-mediated endocytosis. J Cell Biol. 2014;205:721-35 pubmed publisher
    ..Collectively, our results demonstrate precise temporal and quantitative regulation of the dynamin2 recruitment influenced by actin polymerization. ..
  22. Huang F, Khvorova A, Marshall W, Sorkin A. Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem. 2004;279:16657-61 pubmed
    ..This study demonstrates that the efficient gene silencing by rationally designed small interfering RNA can be used as an approach to functionally analyze the entire cellular machineries, such as the clathrin-coated pits and vesicles. ..
  23. Aguet F, Antonescu C, Mettlen M, Schmid S, Danuser G. Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint. Dev Cell. 2013;26:279-91 pubmed publisher
    ..We identify dynamin and the EAP-binding ?-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep maturation process and provide direct evidence for a molecular checkpoint in CME. ..
  24. Neumann S, Schmid S. Dual role of BAR domain-containing proteins in regulating vesicle release catalyzed by the GTPase, dynamin-2. J Biol Chem. 2013;288:25119-28 pubmed publisher
    Dynamin-2 (Dyn2) is ubiquitously expressed and catalyzes membrane fission during clathrin-mediated endocytosis in nonneuronal cells...
  25. Kamagata E, Kudo T, Kimura R, Tanimukai H, Morihara T, Sadik M, et al. Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism. Biochem Biophys Res Commun. 2009;379:691-5 pubmed publisher
    ..In this study we used real-time PCR to show that DNM2 mRNA is significantly reduced in the cortex of AD brains and in the peripheral blood of dementia patients...
  26. Lee E, De Camilli P. Dynamin at actin tails. Proc Natl Acad Sci U S A. 2002;99:161-6 pubmed
    ..Here we show that endogenous dynamin 2, as well as green fluorescence protein fusion proteins of both dynamin 1 and 2, is present in actin comets ..
  27. Cowling B, Toussaint A, Amoasii L, Koebel P, Ferry A, Davignon L, et al. Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness. Am J Pathol. 2011;178:2224-35 pubmed publisher
    b>Dynamin 2 (DNM2) is a large GTPase implicated in many cellular functions, including cytoskeleton regulation and endocytosis...
  28. Hamao K, Morita M, Hosoya H. New function of the proline rich domain in dynamin-2 to negatively regulate its interaction with microtubules in mammalian cells. Exp Cell Res. 2009;315:1336-45 pubmed publisher
    ..Microtubules in cells expressing GFP-dynamin-2-(1-786) were stabilized against exposure to cold. These results provide a first evidence for a regulated interaction of dynamin-2 with microtubules in cultured mammalian cells. ..
  29. Tosoni D, Puri C, Confalonieri S, Salcini A, De Camilli P, Tacchetti C, et al. TTP specifically regulates the internalization of the transferrin receptor. Cell. 2005;123:875-88 pubmed
    ..Thus, TTP might represent one of the long sought for molecules that allow cargo-specific control of clathrin endocytosis...
  30. Kojima C, Hashimoto A, Yabuta I, Hirose M, Hashimoto S, Kanaho Y, et al. Regulation of Bin1 SH3 domain binding by phosphoinositides. EMBO J. 2004;23:4413-22 pubmed
    ..Our results exemplify a novel mechanism of SH3 domain regulation, and suggest that the SH3-mediated protein-protein interactions of Bin1 are regulated by Exon10 so that it may only occur when Bin1 localizes to certain submembrane areas. ..
  31. Zuchner S, Noureddine M, Kennerson M, Verhoeven K, Claeys K, De Jonghe P, et al. Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease. Nat Genet. 2005;37:289-94 pubmed
    ..After screening candidate genes, we identified unique mutations in dynamin 2 (DNM2) in all families...
  32. Fabrizi G, Ferrarini M, Cavallaro T, Cabrini I, Cerini R, Bertolasi L, et al. Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease. Neurology. 2007;69:291-5 pubmed
    Recently, mutations affecting different domains of dynamin-2 (DNM2) were associated alternatively with autosomal dominant centronuclear myopathy or dominant intermediate (demyelinating and axonal) Charcot-Marie-Tooth disease (CMT) type B...
  33. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al. A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem. 2004;279:40091-9 pubmed
    ..These observations therefore indicate that FBP17 interacts with dynamin and regulates endocytosis by forming vesicotubular structures. ..
  34. Cocucci E, Gaudin R, Kirchhausen T. Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit. Mol Biol Cell. 2014;25:3595-609 pubmed publisher
    ..We discuss how these results restrict models for the mechanism of dynamin-mediated membrane scission. ..
  35. Razidlo G, Wang Y, Chen J, Krueger E, Billadeau D, McNiven M. Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1. Dev Cell. 2013;24:573-85 pubmed publisher
    The large GTPase Dynamin 2 (Dyn2) is markedly upregulated in pancreatic cancer, is a potent activator of metastatic migration, and is required for Rac1-mediated formation of lamellipodia...
  36. Moskovich O, Herzog L, Ehrlich M, Fishelson Z. Caveolin-1 and dynamin-2 are essential for removal of the complement C5b-9 complex via endocytosis. J Biol Chem. 2012;287:19904-15 pubmed publisher
    ..Our results show that Cav-1 and dynamin-2 (but not clathrin) support cell resistance to CDC, probably by facilitating purging of the C5b-9 complexes by endocytosis and exo-vesiculation. ..
  37. Xiao D, Chen S, Shao Q, Chen J, Bijian K, Laird D, et al. Dynamin 2 interacts with connexin 26 to regulate its degradation and function in gap junction formation. Int J Biochem Cell Biol. 2014;55:288-97 pubmed publisher
    ..This study identifies dynamin 2 (Dyn2) as a Cx26 interactor in yeast and mammalian cells...
  38. Eppler F, Quast T, Kolanus W. Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion. PLoS ONE. 2017;12:e0172443 pubmed publisher
    ..Taken together, we suggest a previously unidentified role of dynamin2 in the regulation of integrin-mediated lymphocyte adhesion via a Rap1 signaling pathway. ..
  39. Krendel M, Osterweil E, Mooseker M. Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis. FEBS Lett. 2007;581:644-50 pubmed
    ..Expression of Myo1E tail, which acts in a dominant-negative manner, inhibits endocytosis of transferrin. Our findings suggest that myosin 1E may contribute to receptor-mediated endocytosis. ..
  40. Reis C, Chen P, Bendris N, Schmid S. TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation. Proc Natl Acad Sci U S A. 2017;114:504-509 pubmed publisher
    ..the CME of constitutively internalized transferrin receptors is mainly dependent on the ubiquitously expressed Dyn2, TRAIL-induced DR endocytosis is selectively regulated by activation of Dyn1...
  41. Lee J, Westrate L, Wu H, Page C, Voeltz G. Multiple dynamin family members collaborate to drive mitochondrial division. Nature. 2016;540:139-143 pubmed publisher
    ..Here we report that the ubiquitously expressed classical dynamin-2 (Dyn2) is a fundamental component of the mitochondrial division machinery...
  42. Chen S, Huang P, Qiu Y, Zhou Q, Li X, Zhu M, et al. Phenotype variability and histopathological findings in patients with a novel DNM2 mutation. Neuropathology. 2017;: pubmed publisher
    Mutations of Dynamin 2 (DNM2) are responsible for several forms of neuromuscular disorder such as centronuclear myopathy, Charcot-Marie-Tooth disease (CMT) dominant intermediate type B, CMT 2M, and lethal congenital contracture syndrome ..
  43. Chin Y, Lee A, Kan H, Laiman J, Chuang M, Hsieh S, et al. Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation. Hum Mol Genet. 2015;24:5542-54 pubmed publisher
    ..The large GTPase dynamin-2 (Dyn2) is best known for catalyzing membrane fission during clathrin-mediated endocytosis (CME), which is critical for ..
  44. Fan F, Ji C, Wu Y, Ferguson S, Tamarina N, Philipson L, et al. Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis. J Clin Invest. 2015;125:4026-41 pubmed publisher
    ..using temporally controlled gene ablation specifically in β cells in mice, we identified an essential role of dynamin 2 GTPase in preserving normal biphasic insulin secretion and blood glucose homeostasis...
  45. Ge Z, Gu Y, Han Q, Zhao G, Li M, Li J, et al. Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia. Sci Rep. 2016;6:38004 pubmed publisher
    Dynamin-2 (DNM2) is a GTPase essential for intracellular vesicle formation and trafficking, cytokinesis and receptor endocytosis. Mutations in DNM2 are common in early T-cell precursor acute lymphoblastic leukemia...
  46. Szymańska E, Skowronek A, Miaczynska M. Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway. Cell Signal. 2016;28:160-71 pubmed publisher
    ..Here we show that inhibition of dynamin 2 (Dyn2), a major regulator of endocytic internalization, strongly stimulates the AP-1 pathway...
  47. Ishida N, Nakamura Y, Tanabe K, Li S, Takei K. Dynamin 2 associates with microtubules at mitosis and regulates cell cycle progression. Cell Struct Funct. 2011;36:145-54 pubmed
    ..b>Dynamin 2 intensely localized at the mitotic spindle, and the localization depended on its proline-rich domain (PRD), ..
  48. Fattori F, Maggi L, Bruno C, Cassandrini D, Codemo V, Catteruccia M, et al. Centronuclear myopathies: genotype-phenotype correlation and frequency of defined genetic forms in an Italian cohort. J Neurol. 2015;262:1728-40 pubmed publisher
    ..All selected patients were screened for the four 'canonical' genes related to CNMs: MTM1, DNM2, RYR1 and BIN1...
  49. Koutras C, Levesque G. Identification of novel NPRAP/?-catenin-interacting proteins and the direct association of NPRAP with dynamin 2. PLoS ONE. 2011;6:e25379 pubmed publisher
    ..We further validated dynamin 2/NPRAP colocalization and direct interaction in vivo, confirming their bona fide partnership...
  50. Lai W, Huang L, Ho P, Montefiori D, Chen C. The role of dynamin in HIV type 1 Env-mediated cell-cell fusion. AIDS Res Hum Retroviruses. 2011;27:1013-7 pubmed publisher
    ..HIV-1 Env-mediated cell-cell fusion could also be suppressed by a dynamin dominant-negative mutant DNM2(K44A). In summary, these results suggested that dynamin 2 might play a role in HIV-1 Env-mediated cell-cell fusion.
  51. Lin P, Liu X, Zhao D, Dai T, Wu H, Gong Y, et al. DNM2 mutations in Chinese Han patients with centronuclear myopathy. Neurol Sci. 2016;37:995-8 pubmed publisher
    ..Autosomal-dominant centronuclear myopathy-1 (CNM1) results from mutations in the dynamin 2 gene (DNM2) and accounts for approximately 50 % of all CNM cases...
  52. Permanyer M, Ballana E, Badia R, Pauls E, Clotet B, Este J. Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells. J Biol Chem. 2012;287:32017-26 pubmed publisher
    ..Our results suggest that endocytosis is not a mechanism of infection of primary CD4 T cells, but may serve as a reservoir capable of inducing trans-infection of cells after the release of HIV particles to the extracellular environment. ..
  53. Kessels M, Dong J, Leibig W, Westermann P, Qualmann B. Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network. J Cell Sci. 2006;119:1504-16 pubmed
    ..However, molecular details of the function(s) of dynamin II at the Golgi are largely unclear...
  54. Hashimoto S, Hirose M, Hashimoto A, Morishige M, Yamada A, Hosaka H, et al. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2006;103:7036-41 pubmed
    ..Together with fine structural analysis, we propose that the AMAP1/cortactin complex, which is not detected in normal mammary epithelial cells, is an excellent drug target for cancer therapeutics. ..
  55. Heikkilä O, Susi P, Tevaluoto T, Härmä H, Marjomaki V, Hyypia T, et al. Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin. J Virol. 2010;84:3666-81 pubmed publisher
    ..In conclusion, the internalization of CAV9 to A549 cells follows an endocytic pathway that is dependent on integrin alphaVbeta6, beta2-microglobulin, dynamin, and Arf6 but independent of clathrin and caveolin-1. ..
  56. Kim L, Wong T. Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. J Biol Chem. 1998;273:23542-8 pubmed
  57. James N, Digman M, Ross J, Barylko B, Wang L, Li J, et al. A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells. Biochim Biophys Acta. 2014;1840:315-21 pubmed publisher
    b>Dynamin 2 (Dyn2) is a ~100kDa GTPase that assembles around the necks of nascent endocytic and Golgi vesicles and catalyzes membrane scission...
  58. Bosch B, Grigorov B, Senserrich J, Clotet B, Darlix J, Muriaux D, et al. A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission. Antiviral Res. 2008;80:185-93 pubmed publisher
  59. Lynch D, Winata S, Lyons R, Hughes W, Lehrbach G, Wasinger V, et al. A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem. 2003;278:21805-13 pubmed
    ..Therefore, by binding both CD2AP and the Arp2/3 complex, cortactin links receptor endocytosis to actin polymerization, which may facilitate the trafficking of internalized growth factor receptors. ..
  60. Modregger J, Schmidt A, Ritter B, Huttner W, Plomann M. Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1. J Biol Chem. 2003;278:4160-7 pubmed
  61. Gurumurthy R, Chumduri C, Karlas A, Kimmig S, Gonzalez E, Machuy N, et al. Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development. Mol Microbiol. 2014;94:186-201 pubmed publisher
    ..trachomatis inclusions, irrespective of the cell cycle phase. Thus, our study reveals a critical role of dynamin in host-derived lipid acquisition for C. trachomatis development. ..
  62. Hyndman K, Arguello A, Morsing S, Pollock J. Dynamin-2 is a novel NOS1β interacting protein and negative regulator in the collecting duct. Am J Physiol Regul Integr Comp Physiol. 2016;310:R570-7 pubmed publisher
    ..We reported that dynamin-2 (DNM2), a protein involved in excising vesicles from the plasma membrane, and NOS1α form a protein-protein interaction ..
  63. Totta P, Busonero C, Leone S, Marino M, Acconcia F. Dynamin II is required for 17β-estradiol signaling and autophagy-based ERα degradation. Sci Rep. 2016;6:23727 pubmed publisher
    ..Here, we studied the role of the endocytic protein dynamin II in E2-dependent ERα signaling and degradation...
  64. Sever S. Dynamin and endocytosis. Curr Opin Cell Biol. 2002;14:463-7 pubmed
    ..Novel data point more clearly than ever towards a role for this protein in the actin cytoskeleton, mitogen-activated protein kinase signaling and apoptosis, suggesting that dynamin might be a signaling GTPase. ..
  65. Gao Y, Bertuccio C, Balut C, Watkins S, Devor D. Dynamin- and Rab5-dependent endocytosis of a Ca2+ -activated K+ channel, KCa2.3. PLoS ONE. 2012;7:e44150 pubmed publisher
    ..We also demonstrate that KCa2.3 and dynamin II are co-localized following endocytosis as well as demonstrating they are associated by co-IP...
  66. Ménager M, Littman D. Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells. Cell. 2016;164:695-709 pubmed publisher
    ..We identified TSPAN7 and DNM2, which control actin nucleation and stabilization, as having important and distinct roles in limiting HIV-1 ..
  67. Solomaha E, Szeto F, Yousef M, Palfrey H. Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation. J Biol Chem. 2005;280:23147-56 pubmed
    ..Thus, differential binding of SH3 domain-containing proteins to dynamin-1 and -2 may contribute to the distinct functions performed by these isoforms. ..
  68. Bachmann C, Jungbluth H, Muntoni F, Manzur A, Zorzato F, Treves S. Cellular, biochemical and molecular changes in muscles from patients with X-linked myotubular myopathy due to MTM1 mutations. Hum Mol Genet. 2017;26:320-332 pubmed publisher
    Centronuclear myopathies are early-onset muscle diseases caused by mutations in several genes including MTM1, DNM2, BIN1, RYR1 and TTN...
  69. Wan K, Sambi B, Tate R, Waters C, Pyne N. The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor. J Biol Chem. 2003;278:18658-63 pubmed
  70. Meister M, Zuk A, Tikkanen R. Role of dynamin and clathrin in the cellular trafficking of flotillins. FEBS J. 2014;281:2956-76 pubmed publisher
    ..These data show that clathrin and dynamin are required for the endosomal sorting of flotillins, and the study provides a mechanistic dissection of the thus far poorly characterized endosomal trafficking of flotillins. ..
  71. Cowling B, Prokic I, Tasfaout H, Rabai A, Humbert F, Rinaldi B, et al. Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation. J Clin Invest. 2017;127:4477-4487 pubmed publisher
    ..Here, we focused on amphiphysin 2 (BIN1, also known as bridging integrator-1) and dynamin 2 (DNM2), two ubiquitous proteins implicated in membrane remodeling and mutated in centronuclear myopathies (CNMs)...