DNAJC14

Summary

Gene Symbol: DNAJC14
Description: DnaJ heat shock protein family (Hsp40) member C14
Alias: DNAJ, DRIP78, HDJ3, LIP6, dnaJ homolog subfamily C member 14, DnaJ (Hsp40) homolog, subfamily C, member 14, LYST-interacting protein LIP6, dnaJ protein homolog 3, dopamine receptor interacting protein, dopamine receptor-interacting protein of 78 kDa, hDj-3, human DnaJ protein 3
Species: human
Products:     DNAJC14

Top Publications

  1. Bermak J, Li M, Bullock C, Zhou Q. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat Cell Biol. 2001;3:492-8 pubmed
    ..A newly identified ER-membrane-associated protein, DRiP78, binds to this motif...
  2. Leclerc P, Auger Messier M, Lanctot P, Escher E, Leduc R, Guillemette G. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology. 2002;143:4702-10 pubmed
    ..Coexpression of the AT(1) receptor with dopamine receptor interacting protein of 78 kDa, a protein implicated in the cellular routing of the dopamine D1 receptor, increased plasma ..
  3. Yi Z, Sperzel L, N rnberger C, Bredenbeek P, Lubick K, Best S, et al. Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator. PLoS Pathog. 2011;7:e1001255 pubmed publisher
    ..We identified a mammalian Hsp40 chaperone protein (DNAJC14) that when overexpressed was able to mediate protection from yellow fever virus (YFV)-induced cell death...
  4. Kim J, Kim H, Kang G, Kim I, Kim H, Lee Y, et al. The SAV1322 gene from Staphylococcus aureus: genomic and proteomic approaches to identification and characterization of gene function. BMC Microbiol. 2016;16:206 pubmed publisher
    ..genes glmS and murZ are lower, and the expression of heat shock and stress-related genes (hrcA, ctsR, dnaK, dnaJ, grpE, clpB, and clpC) are higher in the sav1322 mutant when compared with the wild-type strain...
  5. Wu H, Shi N, An X, Liu C, Fu H, Cao L, et al. Candidate Genes for Yellow Leaf Color in Common Wheat (Triticum aestivum L.) and Major Related Metabolic Pathways according to Transcriptome Profiling. Int J Mol Sci. 2018;19: pubmed publisher
    ..We also identified heat shock protein (HSP) genes (sHSP, HSP70, HSP90, and DnaJ) and heat shock transcription factor genes that might have vital roles in chloroplast development...
  6. Geider K, Gernold M, Jock S, Wensing A, Völksch B, Gross J, et al. Unifying bacteria from decaying wood with various ubiquitous Gibbsiella species as G. acetica sp. nov. based on nucleotide sequence similarities and their acetic acid secretion. Microbiol Res. 2015;181:93-104 pubmed publisher
    ..Nucleotide sequences from 16S rRNA genes, the housekeeping genes dnaJ, gyrB, recA and rpoB alignments, BLAST searches and phenotypic data confirmed by MALDI-TOF analysis showed that ..
  7. Glasgow E, Murase T, Zhang B, Verbalis J, Gainer H. Gene expression in the rat supraoptic nucleus induced by chronic hyperosmolality versus hyposmolality. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1239-50 pubmed
    ..classes and include cytochrome oxidase, tubulin, Na(+)-K(+)-ATPase, spectrin, PEP-19, calmodulin, GTPase, DnaJ-like, clathrin-associated, synaptic glycoprotein, regulator of GTPase stimulation, and gene for oligodendrocyte ..
  8. Piao D, Shin D, Kim I, Li H, Oh S, Singh B, et al. Trigger factor assisted soluble expression of recombinant spike protein of porcine epidemic diarrhea virus in Escherichia coli. BMC Biotechnol. 2016;16:39 pubmed publisher
    ..proteins at 15 °C was most useful in soluble production of rGST-COE and rGST-S1D compared to GroEL-ES and DnaK-DnaJ-GrpE/GroEL-ES systems...
  9. Hayat B, Padhy B, Mohanty P, Alone D. Altered unfolded protein response and proteasome impairment in pseudoexfoliation pathogenesis. Exp Eye Res. 2019;181:197-207 pubmed publisher
    ..Increased ER stress markers, Synoviolin1, Eukaryotic initiation factor 2-alpha kinase 3, DnaJ (Hsp40) homolog, subfamily B, member 11, Caspase 12, Heat shock 70 kDa protein 5, Heat shock 60 kDa protein 1 ..

More Information

Publications110 found, 100 shown here

  1. Kollanoor Johny A, Frye J, Donoghue A, Donoghue D, Porwollik S, McClelland M, et al. Gene Expression Response of Salmonella enterica Serotype Enteritidis Phage Type 8 to Subinhibitory Concentrations of the Plant-Derived Compounds Trans-Cinnamaldehyde and Eugenol. Front Microbiol. 2017;8:1828 pubmed publisher
    ..Both TC and EG stimulated the transcription of heat shock genes, such as dnaK, dnaJ, ibpB, and ibpA in S. Enteritidis PT8 (P < 0.005)...
  2. Maier M, Luks L, Baudendistel O, Wittmann V, Dietrich D. Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy. Chem Biol Interact. 2018;281:69-80 pubmed publisher
    ..e. chaperones (HSP70 and DnaJ co-chaperones), proteases and proteasomal proteins (regulatory subunits of the 26S proteasome; Rpn1/2)...
  3. Sharma A, Leppla S, Pomerantsev A, Shiloach J. Effect of over expressing protective antigen on global gene transcription in Bacillus anthracis BH500. Sci Rep. 2018;8:16108 pubmed publisher
    ..There were also decreased expression of intracellular heat stress related genes such as groL, groES, hslO, dnaJ, and dnaK and increased expression of extracellular chaperons csaA and prsA2...
  4. Pan M, Zhou Y, Wang Y, Li L, Song Y, Hou L, et al. Screening and Identification of the Host Proteins Interacting with Toxoplasma gondii Rhoptry Protein ROP16. Front Microbiol. 2017;8:2408 pubmed publisher
    ..Two mouse proteins, Dnaja1 (DnaJ heat shock protein family member A1) and Gabra4 (gamma-aminobutyric acid A receptor, subunit alpha 4) were ..
  5. Kim H, Yun J. Checkpoint-dependent phosphorylation of Med1/TRAP220 in response to DNA damage. Acta Biochim Biophys Sin (Shanghai). 2017;49:496-502 pubmed publisher
    ..of the transcription of important regulators of cell cycle control and DNA repair, including p21, Gadd45, Rad50, DnaJ, and RecQL, was impaired upon Med1 knockdown...
  6. Bezzerri V, Cipolli M. Shwachman-Diamond Syndrome: Molecular Mechanisms and Current Perspectives. Mol Diagn Ther. 2019;23:281-290 pubmed publisher
    ..However, it has recently been reported that other genes, including DnaJ heat shock protein family (Hsp40) member C21 (DNAJC21), elongation factor-like 1 (EFL1) and signal recognition ..
  7. Lupoli T, Fay A, Adura C, Glickman M, Nathan C. Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK. Proc Natl Acad Sci U S A. 2016;113:E7947-E7956 pubmed
    ..A point mutation in the highly conserved HPD motif of the DnaJ proteins abrogates their ability to activate DnaK, although the DnaJ2 mutant still binds to DnaK...
  8. Zoppino F, Guerrero Gimenez M, Castro G, Ciocca D. Comprehensive transcriptomic analysis of heat shock proteins in the molecular subtypes of human breast cancer. BMC Cancer. 2018;18:700 pubmed publisher
    ..The strongest downregulation was observed in several HSPB members except for HSPB1. DNAJ members showed heterogeneous expression pattern...
  9. Cassier Chauvat C, Chauvat F. Function and Regulation of Ferredoxins in the Cyanobacterium, Synechocystis PCC6803: Recent Advances. Life (Basel). 2014;4:666-80 pubmed publisher
    ..Furthermore, Fed7 specifically interacts with a DnaJ-like protein, an interaction that has been conserved in photosynthetic eukaryotes in the form of a composite ..
  10. Fan L, Wu X, Tian Z, Jia K, Pan Y, Li J, et al. Comparative proteomic analysis of gamma-aminobutyric acid responses in hypoxia-treated and untreated melon roots. Phytochemistry. 2015;116:28-37 pubmed publisher
    ..GABA treatment enhanced the expression of protein in cytosolic phosphoglycerate kinase 1, exaA2 gene product, dnaJ and myb-like DNA-binding domain-containing proteins, as well as elongation factor-1 alpha and hypothetical proteins ..
  11. Maralit B, Jaree P, Boonchuen P, Tassanakajon A, Somboonwiwat K. Differentially expressed genes in hemocytes of Litopenaeus vannamei challenged with Vibrio parahaemolyticus AHPND (VPAHPND) and VPAHPND toxin. Fish Shellfish Immunol. 2018;81:284-296 pubmed publisher
    ..kinase kinase 4 (MKK4), P38 mitogen-activated protein kinase (P38), protein kinase A regulatory subunit 1 (PKA) and DNAJ homolog subfamily C member 1-like (DNJ) were validated by qRT-PCR...
  12. Gilkes J, Sheen C, Frampton R, Smith G, Dobson R. The first purification of functional proteins from the unculturable, genome reduced, bottlenecked alpha-proteobacterium Candidatus Liberibacter solanacearum. Phytopathology. 2019;: pubmed publisher
    ..with GroEL/GroES, whilst soluble pyruvate kinase was successfully co-expressed with either GroEL/GroES, dnaK/dnaJ/grpE, or a trigger factor...
  13. Taguwa S, Maringer K, Li X, Bernal Rubio D, Rauch J, Gestwicki J, et al. Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection. Cell. 2015;163:1108-1123 pubmed publisher
    ..Hsp70 function at each step is specified by nine distinct DNAJ cofactors...
  14. Eguchi T, Calderwood S, Takigawa M, Kubota S, Kozaki K. Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins. J Cell Biochem. 2017;118:43-51 pubmed publisher
    ..We found that mRNA levels of HSP family members (HSP70B', HSP72, HSP40/DNAJ, and HSP20/CRYAB) are upregulated by the intracellular MMP3 overload...
  15. Shang Y, Yan J, Tang W, Liu C, Xiao S, Guo Y, et al. Mechanistic insights into acephalic spermatozoa syndrome-associated mutations in the human SUN5 gene. J Biol Chem. 2018;293:2395-2407 pubmed publisher
    ..We also found that SUN5 interacts with the coupling apparatus protein DnaJ heat shock protein family (Hsp40) member B13 (DNAJB13) during spermatogenesis, and the substitutions in the SUN5 ..
  16. Song C, Sundqvist G, Malm E, de Bruijn I, Kumar A, van de Mortel J, et al. Lipopeptide biosynthesis in Pseudomonas fluorescens is regulated by the protease complex ClpAP. BMC Microbiol. 2015;15:29 pubmed publisher
    ..The expression of proteins of the citrate cycle and the heat shock proteins DnaK and DnaJ were particularly affected...
  17. Meenakshi S, Munavar M. Suppression of capsule expression in Δlon strains of Escherichia coli by two novel rpoB mutations in concert with HNS: possible role for DNA bending at rcsA promoter. Microbiologyopen. 2015;4:712-29 pubmed publisher
    ..Earlier reports on suppressors for these characteristic lon phenotypes related the role of cochaperon DnaJ and tmRNA...
  18. Chauhan S, Tomar R. Efficient expression and purification of biologically active human cystatin proteins. Protein Expr Purif. 2016;118:10-7 pubmed publisher
    ..Trigger factor, GroES-GroEL, DnaK-DnaJ-GrpE chaperones lead to the presence of cystatin C in the soluble fraction...
  19. Toenshoff E, Fields P, Bourgeois Y, Ebert D. The End of a 60-year Riddle: Identification and Genomic Characterization of an Iridovirus, the Causative Agent of White Fat Cell Disease in Zooplankton. G3 (Bethesda). 2018;8:1259-1272 pubmed publisher
    ..the first invertebrate iridovirus that encodes proteins to purportedly cap RNA, and it contains unique genes for a DnaJ-like protein, a membrane glycoprotein and protein of the immunoglobulin superfamily, which may mediate host-..
  20. Fan D, Liu C, Liu L, Zhu L, Peng F, Zhou Q. Large-scale gene expression profiling reveals physiological response to deletion of chaperone dnaKJ in Escherichia coli. Microbiol Res. 2016;186-187:27-36 pubmed publisher
    Chaperone DnaK and its co-chaperone DnaJ plays various essential roles such as in assisting in the folding of nascent peptides, preventing protein aggregation and maintaining cellular protein homeostasis...
  21. Shi L, Ravikumar V, Derouiche A, Macek B, Mijakovic I. Tyrosine 601 of Bacillus subtilis DnaK Undergoes Phosphorylation and Is Crucial for Chaperone Activity and Heat Shock Survival. Front Microbiol. 2016;7:533 pubmed publisher
    ..In vitro, DnaK Y601F mutant exhibited impaired interaction with its co-chaperones DnaJ and GrpE, along with diminished capacity to hydrolyze ATP and assist the re-folding of denatured proteins...
  22. Majtan T, Liu L, Carpenter J, Kraus J. Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes. J Biol Chem. 2010;285:15866-73 pubmed publisher
    ..Increased levels of molecular chaperones in crude extracts, particularly DnaJ, indicated a rather indirect effect of the chemical chaperones on folding of CBS mutants...
  23. Carroll L, Bergholz T, Hildebrandt I, Marks B. Application of a Nonlinear Model to Transcript Levels of Upregulated Stress Response Gene ibpA in Stationary-Phase Salmonella enterica Subjected to Sublethal Heat Stress. J Food Prot. 2016;79:1089-96 pubmed publisher
    ..05). The transcript levels of ibpA, which codes for a small heat shock protein associated with the ClpB and DnaK-DnaJ-GrpE chaperone systems, showed the greatest increase relative to the transcript levels at 0 min, which was ..
  24. Wang G, Ma C, Luo Y, Zhou S, Zhou Y, Ma X, et al. Proteome and Transcriptome Reveal Involvement of Heat Shock Proteins and Indoleacetic Acid Metabolism Process in Lentinula Edodes Thermotolerance. Cell Physiol Biochem. 2018;50:1617-1637 pubmed publisher
    ..The proteome results revealed that HSPs (heat shock proteins) such as Hsp40 (DnaJ), Hsp70, Hsp90 and key enzymes involved in tryptophan and IAA metabolism process LeTrpE, LeTrpD, LeTam-1, LeYUCCA ..
  25. Woronowicz K, Olubanjo O, Sha D, Kay J, Niederman R. Effects of the protonophore carbonyl-cyanide m-chlorophenylhydrazone on intracytoplasmic membrane assembly in Rhodobacter sphaeroides. Biochim Biophys Acta. 2015;1847:1119-28 pubmed publisher
    ..the preprotein translocase SecY, the SecA translocation ATPase, SecD and SecF insertion components, and chaperonins DnaJ and DnaK, consistent with the possibility that these factors, which act early in the assembly process, have ..
  26. Lampis A, Carotenuto P, Vlachogiannis G, Cascione L, Hedayat S, Burke R, et al. MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma. Gastroenterology. 2018;154:1066-1079.e5 pubmed publisher
    ..MIR21 was shown to target the DnaJ heat shock protein family (Hsp40) member B5 (DNAJB5)...
  27. Wang Z, Xu W, Kang J, Li M, Huang J, Ke Q, et al. Overexpression of alfalfa Orange gene in tobacco enhances carotenoid accumulation and tolerance to multiple abiotic stresses. Plant Physiol Biochem. 2018;130:613-622 pubmed publisher
    ..acid sequence of the deduced MsOr protein revealed that the protein contained two trans-membrane domains and a DnaJ cysteine-rich zinc finger domain, and showed a high level of similarity with the Or protein of other plants species...
  28. Tong Y, Feng S, Xin Y, Yang H, Zhang L, Wang W, et al. Enhancement of soluble expression of codon-optimized Thermomicrobium roseum sarcosine oxidase in Escherichia coli via chaperone co-expression. J Biotechnol. 2016;218:75-84 pubmed publisher
    ..soluble expression of TrSOX was greatly improved by the co-expression of molecular chaperones GroES-GroEL and DnaK-DnaJ-GrpE-GroES-GroEL...
  29. Lee J, Xu Y, Zhang T, Cui L, Saidi L, Ye Y. Secretion of misfolded cytosolic proteins from mammalian cells is independent of chaperone-mediated autophagy. J Biol Chem. 2018;293:14359-14370 pubmed publisher
    ..to the proposed channel function of the LAMP2a isoform because overexpression of a cytosolic MAPS stimulator, DnaJ heat shock protein family (Hsp40) member C5 (DNAJC5), fully rescued the secretion defect associated with LAMP2 ..
  30. Zhang L, Liu S, Liu N, Zhang Y, Liu M, Li D, et al. Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. Protein Cell. 2015;6:42-54 pubmed publisher
    ..Three cytoplasmic proteins, including myosin heavy chain 9 (MYH9), heat shock cognate protein 70 (Hsc70), and dnaJ homolog subfamily A member 1 (DNAJA1), were verified to interact with HDAC6...
  31. Roobol A, Roobol J, Bastide A, Knight J, Willis A, Smales C. p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. Biochem J. 2015;465:213-25 pubmed publisher
    ..The protein p58IPK {also known as DnaJ3C [DnaJ heat-shock protein (hsp) 40 homologue, subfamily C, member 3]} is known to inhibit the eIF2α kinases PKR (dsRNA-..
  32. Tripathy S, Sen R, Padhi S, Sahu D, Nandi S, Mohanty S, et al. Survey of the transcriptome of Brevibacillus borstelensis exposed to low temperature shock. Gene. 2014;550:207-13 pubmed publisher
    ..The microbial stress responsive genes (hsp90, hslU, grpE, dnaK, dnaJ, hslV) and genes under regulatory adaptive responses (rpoN) were identified...
  33. Lopes Pacheco M, Boinot C, Sabirzhanova I, Morales M, Guggino W, Cebotaru L. Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27. J Biol Chem. 2015;290:25636-45 pubmed publisher
    ..the binding of proteins involved in endoplasmic reticulum-associated degradation, such as Hsp27 (HspB1) and Hsp40 (DnaJ). We saw a dramatic reduction in binding to heat shock proteins 27 and 40 following combined corrector therapy...
  34. Mishra R, Grover A. ClpB/Hsp100 proteins and heat stress tolerance in plants. Crit Rev Biotechnol. 2016;36:862-74 pubmed publisher
    ..Chaperones such as GroEL/GroES (Hsp60/Hsp10) and DnaK/DnaJ/GrpE (Hsp70/Hsp40/nucleotide exchange factor) help cells minimize protein aggregation...
  35. Brooks J, Gyllborg M, Cronin D, Quillin S, Mallama C, Foxall R, et al. Global discovery of colonization determinants in the squid symbiont Vibrio fischeri. Proc Natl Acad Sci U S A. 2014;111:17284-9 pubmed publisher
    ..Biofilm formation in culture and in vivo was abolished in a strain lacking the cytoplasmic chaperone DnaJ, suggesting an important role for protein quality control during the elaboration of bacterial biofilm in the ..
  36. Wu Y, Luo L, Chen L, Tao X, Huang M, Wang H, et al. Chromosome mapping, molecular cloning and expression analysis of a novel gene response for leaf width in rice. Biochem Biophys Res Commun. 2016;480:394-401 pubmed publisher
    ..3 kb between the InDel markers N10 and InD5016. There are 9 genes in the mapping interval, and only a heat shock DNAJ protein encode gene (Os07g09450) has a specific G to T SNP, which was occurred at the last base of the second exon ..
  37. Wang C, Shyu R, Wu C, Chen M, Lee M, Lin Y, et al. Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells. Mol Cells. 2018;41:562-574 pubmed publisher
    ..Here, we show that DnaJ heat shock protein family member C8 (DNAJC8) is a TIG1 target that regulates glycolysis...
  38. Zhang H, Yang J, Wu S, Gong W, Chen C, Perrett S. Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response. J Biol Chem. 2016;291:6967-81 pubmed publisher
    ..DnaK cooperates with the Hsp40 co-chaperone DnaJ and the nucleotide exchange factor GrpE...
  39. Miyazaki R, Yura T, Suzuki T, Dohmae N, Mori H, Akiyama Y. A Novel SRP Recognition Sequence in the Homeostatic Control Region of Heat Shock Transcription Factor ?32. Sci Rep. 2016;6:24147 pubmed publisher
    ..observed was significantly affected by mutations in this region that compromise the feedback regulation, but not by deleting the DnaK/DnaJ chaperones. Homeostatic regulation of HSR thus requires a novel type of SRP recognition mechanism.
  40. Deyssenroth M, Peng S, Hao K, Lambertini L, Marsit C, Chen J. Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth. BMC Genomics. 2017;18:520 pubmed publisher
    ..and gene expression, were associated with birth weight; hub genes of all five modules (CREB3, DDX3X, DNAJC14, GRHL1 and C21orf91) were significantly associated with fetal growth restriction, and one hub gene (CREB3) was ..
  41. Kityk R, Kopp J, Mayer M. Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones. Mol Cell. 2018;69:227-237.e4 pubmed publisher
    ..We present the crystal structure of the J-domain of Escherichia coli DnaJ in complex with the E. coli Hsp70 DnaK...
  42. Li H, Chang L, Howell J, Turner R. DmsD, a Tat system specific chaperone, interacts with other general chaperones and proteins involved in the molybdenum cofactor biosynthesis. Biochim Biophys Acta. 2010;1804:1301-9 pubmed publisher
    ..From these data, DmsD was confirmed to interact with the general molecular chaperones DnaK, DnaJ, GrpE, GroEL, Tig and Ef-Tu...
  43. Kwon S, Kim S, Song N, Chang S, Hwang Y, Yang D, et al. Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1. J Nutr Biochem. 2016;30:24-32 pubmed publisher
    ..Together, our data implicate luteolin as an ingredient and Dnajb1 as a molecular target for the development of functional foods and drugs in metabolic and bone-related diseases. ..
  44. Lu X, He S, Zong H, Song J, Chen W, Zhuge B. Improved 1, 2, 4-butanetriol production from an engineered Escherichia coli by co-expression of different chaperone proteins. World J Microbiol Biotechnol. 2016;32:149 pubmed publisher
    ..The plasmid pKJE7 harboring dnaK-dnaJ-grpE showed significant negative effects on these enzyme activities and cell growth, leading to completely ..
  45. Deane C, Brown I. Components of a mammalian protein disaggregation/refolding machine are targeted to nuclear speckles following thermal stress in differentiated human neuronal cells. Cell Stress Chaperones. 2017;22:191-200 pubmed publisher
    ..Members of the DNAJ (Hsp40) family act as "holdases" that detect and bind misfolded proteins, while members of the HSPA (Hsp70) family ..
  46. Gialama D, Delivoria D, Michou M, Giannakopoulou A, Skretas G. Functional Requirements for DjlA- and RraA-Mediated Enhancement of Recombinant Membrane Protein Production in the Engineered Escherichia coli Strains SuptoxD and SuptoxR. J Mol Biol. 2017;429:1800-1816 pubmed publisher
    ..Here, we investigated the functional requirements for DnaJ-like protein A (DjlA)- and regulator of ribonuclease activity A (RraA)-mediated enhancement of recombinant MP ..
  47. Xu X, Liang K, Niu Y, Shen Y, Wan X, Li H, et al. BAH1 an E3 Ligase from Arabidopsis thaliana Stabilizes Heat Shock Factor ?32 of Escherichia coli by Interacting with DnaK/DnaJ Chaperone Team. Curr Microbiol. 2018;75:450-455 pubmed publisher
    In Escherichia coli, the DnaK/DnaJ chaperone can control the stability and activity of ?32, which is the key factor in heat shock response. Heterologous expression of eukaryotic molecular chaperones protects E...
  48. Rodrigo W, Dassanayake R, Karunanayake E, Gunawardene Y, Weerasena O. Heterologous expression, chaperone mediated solubilization and purification of parasitic nematode-specific growth factor-like protein of Setaria digitata. Asian Pac J Trop Med. 2014;7:85-92 pubmed publisher
    ..of SDUG using chaperone plasmids pG-KJE8, pGro 7, pKJE7, pG-Tf2 and pTf16 containing chaperone proteins of dnaK-dnaJ-grpE-groES-gro-E, groES-groEL, dnaK-dnaJ-grpE, groES-groEL-tig, and tig respectively, was carried out subsequently...
  49. Sun T, Zhou F, Liu C, Zhuang Z, Lu S. The DnaJ-like zinc finger domain protein ORANGE localizes to the nucleus in etiolated cotyledons of Arabidopsis thaliana. Protoplasma. 2016;253:1599-1604 pubmed
    Vitamin A deficiency (VAD) is a worldwide health problem. Overexpression of the DnaJ-like zinc finger domain protein ORANGE (OR) is a novel strategy for the biofortification of pro-vitamin A carotenoids in different staple crops to ..
  50. Zagari N, Sandoval Ibañez O, Sandal N, Su J, Rodríguez Concepción M, Stougaard J, et al. SNOWY COTYLEDON 2 Promotes Chloroplast Development and Has a Role in Leaf Variegation in Both Lotus japonicus and Arabidopsis thaliana. Mol Plant. 2017;10:721-734 pubmed publisher
    ..Snowy cotyledon 2 (SCO2) is a DNAJ-like protein involved in thylakoid membrane biogenesis and interacts with the light-harvesting chlorophyll-binding ..
  51. Niu G, Zhang H, Liu D, Chen L, Belani C, Wang H, et al. Tid1, the Mammalian Homologue of Drosophila Tumor Suppressor Tid56, Mediates Macroautophagy by Interacting with Beclin1-containing Autophagy Protein Complex. J Biol Chem. 2015;290:18102-10 pubmed publisher
    ..We here show that Tid1, a DnaJ co-chaperone for Hsp70 and the mammalian homologue of the Drosophila tumor suppressor Tid56, is a key mediator of ..
  52. Zhu X, Liang S, Yin J, Yuan C, Wang J, Li W, et al. The DnaJ OsDjA7/8 is essential for chloroplast development in rice (Oryza sativa). Gene. 2015;574:11-9 pubmed publisher
    b>DnaJ proteins belong to chaperones of Hsp40 family that ubiquitously participate in various cellular processes. Previous studies have shown chloroplast-targeted DnaJs are involved in the development of chloroplast in some plant species...
  53. Park S, Choi H, Seo J, Yoo J, Jeong J, Choi Y, et al. DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signaling. Biochim Biophys Acta. 2015;1853:2722-30 pubmed publisher
    ..Here, using a yeast two-hybrid screen, we identified DnaJ homolog subfamily B member I (DNAJB1) as a novel MIG6-interacting protein...
  54. Li Y, Bu C, Li T, Wang S, Jiang F, Yi Y, et al. Cloning and analysis of DnaJ family members in the silkworm, Bombyx mori. Gene. 2016;576:88-98 pubmed publisher
    ..mori) transcriptome databases, we identified 27 cDNA sequences encoding the conserved J domain, which is found in DnaJ-type Hsps. Of the 27 J domain-containing sequences, 25 were complete cDNA sequences...
  55. Simon E, Freije C, Farber B, Lalazar G, Darcy D, Honeyman J, et al. Transcriptomic characterization of fibrolamellar hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2015;112:E5916-25 pubmed publisher
    ..carry a deletion of ∼ 400 kb in chromosome 19, resulting in a fusion of the genes for the heat shock protein, DNAJ (Hsp40) homolog, subfamily B, member 1, DNAJB1, and the catalytic subunit of protein kinase A, PRKACA...
  56. Fujimori T, Suno R, Iemura S, Natsume T, Wada I, Hosokawa N. Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation. Genes Cells. 2017;22:684-698 pubmed publisher
    ..of BiP is regulated by its intrinsic ATPase activity, which is stimulated by ER-resident proteins of the HSP40/DnaJ family, including ERdj3...
  57. Servas C, Römisch K. The Sec63p J-domain is required for ERAD of soluble proteins in yeast. PLoS ONE. 2013;8:e82058 pubmed publisher
    ..We show that a mutation in the DnaJ-domain of Sec63p causes a defect in ERAD, whereas mutations in the Brl, acidic, and transmembrane domains only ..
  58. Rasmussen J, Fletcher J, Long M, Allen L, Jones B. Characterization of Francisella tularensis Schu S4 mutants identified from a transposon library screened for O-antigen and capsule deficiencies. Front Microbiol. 2015;6:338 pubmed publisher
    ..the following transposon mutations: FTT0846::Tn5, hemH::Tn5, wbtA::Tn5, wzy::Tn5, FTT0673p/prsA::Tn5, manB::Tn5, or dnaJ::Tn5. Each of these strains displayed sensitivity to human serum, to varying degrees, when compared to wild-type F...
  59. Ma Z, Leng Y, Chen G, Zhou P, Ye D, Chen L. The THERMOSENSITIVE MALE STERILE 1 Interacts with the BiPs via DnaJ Domain and Stimulates Their ATPase Enzyme Activities in Arabidopsis. PLoS ONE. 2015;10:e0132500 pubmed publisher
    ..luciferase complementary imaging (LCI), GST pull-down and ATPase enzyme activity assays demonstrated that the DnaJ domain of TMS1 could interact with BiP1 and BiP3, and could stimulate their ATPase enzyme activities...
  60. Grudniak A, WÅ‚odkowska J, Wolska K. Chaperone DnaJ Influences the Formation of Biofilm by Escherichia coli. Pol J Microbiol. 2015;64:279-83 pubmed
    b>DnaJ chaperone, a member of the so called DnaK-DnaJ-GrpE chaperone machine plays an important role in cell physiology. The ability of Escherichia coli ΔdnaJ mutant to form biofilm was studied...
  61. Król J, Wanecka A, Twardoń J, Mrowiec J, Dropińska A, Bania J, et al. Isolation of Staphylococcus microti from milk of dairy cows with mastitis. Vet Microbiol. 2016;182:163-9 pubmed publisher
    ..approaches: nucleotide sequence analysis of the 16S rRNA gene, as well as some housekeeping genes (sodA, rpoB, dnaJ), and matrix-assisted laser desorption ionization-time of flight mass spectrometry. All S...
  62. Tsou W, Ouyang M, Hosking R, Sutton J, Blount J, Burr A, et al. The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster. Neurobiol Dis. 2015;82:12-21 pubmed publisher
    ..this deubiquitinase, through its interaction with Rad23, leads to increased protein levels of the co-chaperone DnaJ-1 and depends on it to protect against degeneration...
  63. Niederman R. Development and dynamics of the photosynthetic apparatus in purple phototrophic bacteria. Biochim Biophys Acta. 2016;1857:232-46 pubmed publisher
    ..the SecA translocation ATPase, the preprotein translocase SecY, SecD and SecF insertion components, and chaperonins DnaJ and DnaK, which act early in the assembly process...
  64. Yamashita M, Hirohashi Y, Torigoe T, Kusumoto H, Murai A, Imagawa T, et al. Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response. PLoS ONE. 2016;11:e0146501 pubmed publisher
    ..In a previous study, we showed by gene knockdown using siRNA and gene overexpression experiments that Dnaj (Hsp40) homolog, subfamily B, member 8 (DNAJB8), a role in the maintenance, of renal cell carcinoma CSCs/CICs...
  65. Chen J, Huang Y, Wu H, Ni X, Cheng H, Fan J, et al. Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain. J Hum Genet. 2003;48:217-21 pubmed
    ..fetal brain cDNA library, we isolated a cDNA of 3249 bp encoding a novel human J-domain protein, which was named as HDJ3. The expression pattern of HDJ3 was examined by reverse transcription/polymerase chain reaction, which suggested ..
  66. Aprile F, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Sci Rep. 2017;7:9039 pubmed publisher
    ..Here, we demonstrate that a CRISPR/Cas9-mediated knockout (KO) of a DnaJ protein, DNAJB6, in HEK293T cells expressing α-syn, causes a massive increase in α-syn aggregation...
  67. Dasari S, Alexander M, Vrana J, Theis J, Mills J, Negron V, et al. DnaJ Heat Shock Protein Family B Member 9 Is a Novel Biomarker for Fibrillary GN. J Am Soc Nephrol. 2018;29:51-56 pubmed publisher
    ..We analyzed the proteomic content of glomeruli in patient biopsy specimens and detected DnaJ heat shock protein family (Hsp40) member B9 (DNAJB9) as the fourth most abundant protein in FGN glomeruli...
  68. Jahangirizadeh Z, Ghafouri H, Sajedi R, Sarikhan S, Taghdir M, Sariri R. Molecular cloning, prokaryotic expression, purification, structural studies and functional implications of Heat Shock Protein 70 (Hsp70) from Rutilus frisii kutum. Int J Biol Macromol. 2018;108:798-807 pubmed publisher
    ..the purified Hsp70 chaperone was able to considerably suppress heat-induced aggregation of luciferase by binding to DnaJ co-chaperone (5?M) more than 70% after 10min at 42°C...
  69. Sanchez E, Darvish H, Mesias R, Taghavi S, Firouzabadi S, Walker R, et al. Identification of a Large DNAJB2 Deletion in a Family with Spinal Muscular Atrophy and Parkinsonism. Hum Mutat. 2016;37:1180-1189 pubmed publisher
    ..8 kb deletion, spanning the entire DnaJ domain of the HSJ1 protein, as the disease-segregating mutation...
  70. Ottaviani D, Marin O, Arrigoni G, Franchin C, Vilardell J, Sandre M, et al. Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain. Hum Mol Genet. 2017;26:611-623 pubmed publisher
    HSJ1 (DNAJB2), a member of the DNAJ family of molecular chaperones, is a key player in neuronal proteostasis maintenance...
  71. Engelholm L, Riaz A, Serra D, Dagnæs Hansen F, Johansen J, Santoni Rugiu E, et al. CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma. Gastroenterology. 2017;153:1662-1673.e10 pubmed publisher
    ..A somatic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ heat shock protein family (Hsp40) member B1 gene (DNAJB1) to the protein kinase cAMP-activated catalytic subunit ..
  72. Qiu Y, Zhang X, Wang H, Zhang X, Mo Y, Sun X, et al. Heterologous prime-boost immunization with live SPY1 and DnaJ protein of Streptococcus pneumoniae induces strong Th1 and Th17 cellular immune responses in mice. J Microbiol. 2017;55:823-829 pubmed publisher
    ..study, to decrease the doses of live SPY1 and improve the safety of SPY1 vaccine, we immunized mice with SPY1 and DnaJ protein alternately...
  73. Andeen N, Yang H, Dai D, MacCoss M, Smith K. DnaJ Homolog Subfamily B Member 9 Is a Putative Autoantigen in Fibrillary GN. J Am Soc Nephrol. 2018;29:231-239 pubmed publisher
    ..These studies identified DnaJ homolog subfamily B member 9 (DNAJB9) as a highly sampled protein detected only in fibrillary GN cases...
  74. Wang X, Yuan T, Yuan J, Su Y, Sun X, Wu J, et al. Expression of Toll-Like Receptor 2 by Dendritic Cells Is Essential for the DnaJ-?A146Ply-Mediated Th1 Immune Response against Streptococcus pneumoniae. Infect Immun. 2018;86: pubmed publisher
    The fusion protein DnaJ-?A146Ply could induce cross-protective immunity against pneumococcal infection via mucosal and subcutaneous immunization in mice in the absence of additional adjuvants...
  75. Bozzacco L, Yi Z, Andreo U, Conklin C, Li M, Rice C, et al. Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication. J Virol. 2016;90:3212-28 pubmed publisher
    b>DNAJC14, a heat shock protein 40 (Hsp40) cochaperone, assists with Hsp70-mediated protein folding...
  76. Takayanagi Kiya S, Jin Y. Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model. G3 (Bethesda). 2016;6:2165-71 pubmed publisher
    The highly conserved cochaperone DnaJ/Hsp40 family proteins are known to interact with molecular chaperone Hsp70, and can regulate many cellular processes including protein folding, translocation, and degradation...
  77. Gobeli Brawand S, Cotting K, Gómez Sanz E, Collaud A, Thomann A, Brodard I, et al. Macrococcus canis sp. nov., a skin bacterium associated with infections in dogs. Int J Syst Evol Microbiol. 2017;67:621-626 pubmed publisher
    ..caseolyticus, the novel strains shared only 90.8 to 93.5?%?DNA sequence identity with cpn60, dnaJ, rpoB and sodA partial genes, respectively...
  78. Pantucek R, Sedláček I, Indráková A, Vrbovská V, Mašlaňová I, Kovařovic V, et al. Staphylococcus edaphicus sp. nov., Isolated in Antarctica, Harbors the mecC Gene and Genomic Islands with a Suspected Role in Adaptation to Extreme Environments. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..as confirmed by multilocus sequence analysis of six housekeeping genes, rpoB, hsp60, tuf, dnaJ, gap, and sod Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-..
  79. Modesto M, Michelini S, Sansosti M, De Filippo C, Cavalieri D, Qvirist L, et al. Bifidobacterium callitrichidarum sp. nov. from the faeces of the emperor tamarin (Saguinus imperator). Int J Syst Evol Microbiol. 2017;: pubmed publisher
    ..3?%), Bifidobacterium longumsubsp. infantis ATCC 15697T (dnaJ 85.3?%) and Bifidobacterium longumsubsp. longum ATCC 15708 (rpoB 93?%), respectively...
  80. Kuang Y, Charette N, Frazer J, Holland P, Attwood K, Dellaire G, et al. Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization. PLoS ONE. 2012;7:e40522 pubmed publisher
    ..We identified a molecular chaperone, DRiP78, that interacts with both CXCR4 and CCR5, but not the heterodimer formed by these receptors...
  81. Chamakura K, Tran J, Young R. MS2 Lysis of Escherichia coli Depends on Host Chaperone DnaJ. J Bacteriol. 2017;199: pubmed publisher
    ..expression and shown to have a missense change of the highly conserved proline (P330Q) in the C-terminal domain of DnaJ. In the dnaJP330Q mutant host, L-mediated lysis is completely blocked at 30°C without ..
  82. Hishiya A, Koya K. Artificial DnaJ Protein for protein production and conformational diseases. Sci Rep. 2017;7:8531 pubmed publisher
    ..In this study, we exploited co-expression of an artificial fusion protein, based on the sequence of a DnaJ protein, which could interact as co-chaperones in the Hsp70-based protein-folding system, with target recombinant ..
  83. Xue Y, Zhou L, Sun Y, Li H, Jones G, Song Y. Steered molecular dynamics simulation of the binding of the bovine auxilin J domain to the Hsc70 nucleotide-binding domain. J Mol Model. 2017;23:320 pubmed publisher
    ..Asp876, Lys877, and Phe891 were also found in a previous study to be indispensable to the catalytic activity of the DnaJ J domain and the binding of it with the NBD of DnaK...
  84. Zarouchlioti C, Parfitt D, Li W, Gittings L, Cheetham M. DNAJ Proteins in neurodegeneration: essential and protective factors. Philos Trans R Soc Lond B Biol Sci. 2018;373: pubmed publisher
    ..There are many different families of molecular chaperones with multiple functions in proteostasis. The DNAJ family of molecular chaperones is the largest chaperone family and is defined by the J-domain, which regulates the ..
  85. Muñoz Nortes T, Perez Perez J, Ponce M, Candela H, Micol J. The ANGULATA7 gene encodes a DnaJ-like zinc finger-domain protein involved in chloroplast function and leaf development in Arabidopsis. Plant J. 2017;89:870-884 pubmed publisher
    ..ANU7 encodes a plant-specific protein that contains a domain similar to the central cysteine-rich domain of DnaJ proteins...
  86. Yang X, Hu Y, Liu Y, Liu W, Zhao X, Liu M, et al. C14orf28 downregulated by miR-519d contributes to oncogenicity and regulates apoptosis and EMT in colorectal cancer. Mol Cell Biochem. 2017;434:197-208 pubmed publisher
    ..Together, these results evidenced that C14orf28 downregulated by miR-519d contributes to tumorigenesis and might provide new potential targets for colorectal cancer therapy. ..
  87. Bermak J, Zhou Q. Accessory proteins in the biogenesis of G protein-coupled receptors. Mol Interv. 2001;1:282-7 pubmed
    ..These exciting discoveries have shifted earlier paradigms of GPCR functionality. ..
  88. Ito N, Kamiguchi K, Nakanishi K, Sokolovskya A, Hirohashi Y, Tamura Y, et al. A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner. Biochem Biophys Res Commun. 2016;474:626-633 pubmed publisher
    ..In this study, we report that a novel J-protein, DNAJ (HSP40) Homolog, Subfamily C, Member 8 (DNAJC8), suppresses the aggregation of polyQ-containing protein in a ..
  89. Wu Y, Cui J, Zhang X, Gao S, Ma F, Yao H, et al. Pneumococcal DnaJ modulates dendritic cell-mediated Th1 and Th17 immune responses through Toll-like receptor 4 signaling pathway. Immunobiology. 2017;222:384-393 pubmed publisher
    Pneumococcal DnaJ was recently shown to be a potential protein vaccine antigen that induces strong Th1 and Th17 immune response against streptococcus pneumoniae infection in mice...
  90. Buján N, Mohammed H, Balboa S, Romalde J, Toranzo A, Arias C, et al. Genetic studies to re-affiliate Edwardsiella tarda fish isolates to Edwardsiella piscicida and Edwardsiella anguillarum species. Syst Appl Microbiol. 2018;41:30-37 pubmed publisher
    ..The study of the taxonomic resolution of the genes 16S rRNA, adk, atpD, dnaJ, glnA, hsp60, tuf as well as the possible combinations among housekeeping genes, showed that the gene dnaJ was the ..
  91. Dyer J, Dutta A, Gogol M, Weake V, Dialynas G, Wu X, et al. Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression. J Mol Biol. 2017;429:2093-2107 pubmed publisher
    ..Here, we describe a proteomics approach that identifies MLF as a member of a nuclear chaperone complex containing a DnaJ protein, BCL2-associated anthanogene 2, and Hsc70...
  92. Gomes C, Soh J. DnaJC18, a Novel Type III DnaJ Family Protein, is Expressed Specifically in Rat Male Germ Cells. Dev Reprod. 2017;21:237-247 pubmed publisher
    ..using representational difference analysis (RDA) method, a complimentary DNA clone encoding type III member of a DnaJ family protein, DnaJC18, was cloned (GenBank Accession No. DQ158861)...