Gene Symbol: DNAJC1
Description: DnaJ heat shock protein family (Hsp40) member C1
Alias: DNAJL1, ERdj1, HTJ1, MTJ1, dnaJ homolog subfamily C member 1, DnaJ (Hsp40) homolog, subfamily C, member 1, DnaJ-like protein, dnaJ protein homolog MTJ1
Species: human
Products:     DNAJC1

Top Publications

  1. Piles M, Fernandez Lozano C, Velasco Galilea M, González Rodríguez O, Sanchez J, Torrallardona D, et al. Machine learning applied to transcriptomic data to identify genes associated with feed efficiency in pigs. Genet Sel Evol. 2019;51:10 pubmed publisher
    ..were NRF2-mediated oxidative stress response and aldosterone signalling in epithelial cells, the DNAJC6, DNAJC1, MAPK8, PRKD3 genes in duodenum, and melatonin degradation II, PPARα/RXRα activation, and GPCR-mediated nutrient ..
  2. Matsumoto D, Tao R. Recognition of S-RNases by an S locus F-box like protein and an S haplotype-specific F-box like protein in the Prunus-specific self-incompatibility system. Plant Mol Biol. 2019;: pubmed publisher
    ..These results suggest that SLFLs and SFBLs could act as predominant GIs in Prunus-specific S-RNase-based GSI. ..
  3. Cassier Chauvat C, Chauvat F. Function and Regulation of Ferredoxins in the Cyanobacterium, Synechocystis PCC6803: Recent Advances. Life (Basel). 2014;4:666-80 pubmed publisher
    ..Fed9 specifically interacts with the Flv3 flavodiiron protein acting in the photoreduction of O2 to H2O. ..
  4. Zagari N, Sandoval Ibañez O, Sandal N, Su J, Rodríguez Concepción M, Stougaard J, et al. SNOWY COTYLEDON 2 Promotes Chloroplast Development and Has a Role in Leaf Variegation in Both Lotus japonicus and Arabidopsis thaliana. Mol Plant. 2017;10:721-734 pubmed publisher
    ..Taken together, our results indicate that SCO2 plays a distinct role in PSII assembly or repair and constitutes a novel factor involved in leaf variegation. ..
  5. Gialama D, Delivoria D, Michou M, Giannakopoulou A, Skretas G. Functional Requirements for DjlA- and RraA-Mediated Enhancement of Recombinant Membrane Protein Production in the Engineered Escherichia coli Strains SuptoxD and SuptoxR. J Mol Biol. 2017;429:1800-1816 pubmed publisher
  6. Toenshoff E, Fields P, Bourgeois Y, Ebert D. The End of a 60-year Riddle: Identification and Genomic Characterization of an Iridovirus, the Causative Agent of White Fat Cell Disease in Zooplankton. G3 (Bethesda). 2018;8:1259-1272 pubmed publisher
    ..Our findings end a 60-year search for the causative agent of WFCD and add to our knowledge of iridovirus genomics and invertebrate-virus interactions. ..
  7. Vasilevskaya I, Selvakumaran M, Roberts D, O Dwyer P. JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy. Mol Cancer Res. 2016;14:753-63 pubmed publisher
    ..was defined using HT29-derived cell lines stably expressing dominant-negative constructs for JNK1 and JNK2 (HTJ1.3 and HTJ2.2, respectively)...
  8. Chevalier M, Rhee H, Elguindi E, Blond S. Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1. J Biol Chem. 2000;275:19620-7 pubmed
    ..We show here that murine BiP/GRP78 interacts with the lumenal J domain of the murine transmembrane protein MTJ1 (J-MTJ1). J-MTJ1 stimulates the ATPase activity of BiP/GRP78 at stoichiometric concentrations...
  9. Kroczynska B, Evangelista C, Samant S, Elguindi E, Blond S. The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity. J Biol Chem. 2004;279:11432-43 pubmed
    The murine tumor cell DnaJ-like protein 1 or MTJ1/ERdj1 is a membrane J-domain protein enriched in microsomal and nuclear fractions...

More Information


  1. Schorr S, Klein M, Gamayun I, Melnyk A, Jung M, Schäuble N, et al. Co-chaperone Specificity in Gating of the Polypeptide Conducting Channel in the Membrane of the Human Endoplasmic Reticulum. J Biol Chem. 2015;290:18621-35 pubmed publisher
  2. Ramos Lopez O, Riezu Boj J, Milagro F, Martinez J. DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance. Mol Genet Metab. 2018;123:50-58 pubmed publisher
    ..casp12), cg24776411 (eif2ak1), cg14190817 (hspa5), cg21376454 (ern1), cg06666486 (eif2ak1), cg03211481 (dnajc1), cg18357645 (os9), cg05801879 (mbtps1), cg20964082 (ero1lb), cg17300868 (nfe2l2), cg03384128 (eif2ak4), ..
  3. Kroczynska B, King Simmons L, Alloza L, Alava M, Elguindi E, Blond S. BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4. Biochem Biophys Res Commun. 2005;338:1467-77 pubmed
    MTJ1/ERdj1 and its human homologue HTJ1 are membrane proteins that interact with the molecular chaperone BiP through their J-domain...
  4. Sung Y, Perusse L, Sarzynski M, Fornage M, Sidney S, Sternfeld B, et al. Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat. Int J Obes (Lond). 2016;40:662-74 pubmed publisher
    ..0 × 10(-8)) locus for SAT in women with 11 SNPs encompassing the MLLT10, DNAJC1 and EBLN1 genes on chromosome 10p12.31 (P=3.97 × 10(-8) to 1.13 × 10(-8))...