DNAJA1

Summary

Gene Symbol: DNAJA1
Description: DnaJ heat shock protein family (Hsp40) member A1
Alias: DJ-2, DjA1, HDJ2, HSDJ, HSJ-2, HSJ2, HSPF4, NEDD7, hDJ-2, dnaJ homolog subfamily A member 1, DnaJ (Hsp40) homolog, subfamily A, member 1, dnaJ protein homolog 2, heat shock 40 kDa protein 4, heat shock protein J2, heat shock protein, DNAJ-like 2, human DnaJ protein 2, neural precursor cell expressed, developmentally down-regulated 7
Species: human
Products:     DNAJA1

Top Publications

  1. Kanazawa M, Terada K, Kato S, Mori M. HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria. J Biochem. 1997;121:890-5 pubmed
    The role of HSDJ, a human homolog of bacterial DnaJ and yeast YDJ1p/MAS5, in mitochondrial protein import was examined. Recombinant HSDJ was purified and an antibody was prepared. HSDJ mRNA was heat-induced in cultured cells...
  2. Terada K, Oike Y. Multiple molecules of Hsc70 and a dimer of DjA1 independently bind to an unfolded protein. J Biol Chem. 2010;285:16789-97 pubmed publisher
    ..Refolding of an unfolded protein is efficiently mediated by the Hsc70 system with either type 1 DnaJ protein, DjA1 or DjA2, and a nucleotide exchange factor...
  3. Gotoh T, Terada K, Oyadomari S, Mori M. hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ. 2004;11:390-402 pubmed
    ..We also showed that the cytosolic chaperone pair of hsp70 and dj1 (hsp40/hdj-1) or dj2 (HSDJ/hdj-2) prevents NO-mediated apoptosis upstream of cytochrome c release from mitochondria...
  4. Feng X, Yang X, Ruan J, Wang Y, Zhou Y, Xu D, et al. Molecular cloning and characteristics of DnaJa1and DnaJb1 in Coilia nasus: possible function involved in oogenesis during spawning migration. BMC Dev Biol. 2019;19:9 pubmed publisher
    ..In this regard, two DnaJs (Cn-DnaJa1 and Cn-DnaJb1) are cloned from the Coilia nasus's ovary...
  5. Wu Y, Zhang J, Fang L, Lee H, Zhao Y. A cytosolic chaperone complex controls folding and degradation of type III CD38. J Biol Chem. 2019;294:4247-4258 pubmed publisher
    ..More remarkably, DNAJA1 knockdown decreased sCD38 but increased type III CD38 levels...
  6. Sluder I, Nitika -, Knighton L, Truman A. The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity. PLoS Genet. 2018;14:e1007462 pubmed publisher
    ..Suggesting broad conservation from yeast to human, HDJ2 binds R2B and regulates RNR stability in human cells...
  7. Ugolini Lopes M, Torrezan G, Gândara A, Olivieri E, Nascimento I, Okazaki E, et al. Enhanced type I interferon gene signature in primary antiphospholipid syndrome: Association with earlier disease onset and preeclampsia. Autoimmun Rev. 2019;18:393-398 pubmed publisher
    ..An ROC curve defined the signature cut-off. Six genes remained in the IFN signature DNAJA1, IFIT5, IFI27, MX1, IFI6, and TYK2. The ROC cutoff was 3.9-fold (AUC = 0.706, S = 0.49, E = 0...
  8. Britten C, Rowinsky E, Soignet S, Patnaik A, Yao S, Deutsch P, et al. A phase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies. Clin Cancer Res. 2001;7:3894-903 pubmed
    ..cells (PBMCs) were sampled to detect and monitor the inhibitory effects of L-778,123 on the prenylation of HDJ2, a chaperone protein that undergoes farnesylation. Twenty-five patients received 51 complete courses of L-778,123...
  9. Nguyen E, Centenera M, Moldovan M, Das R, Irani S, Vincent A, et al. Identification of Novel Response and Predictive Biomarkers to Hsp90 Inhibitors Through Proteomic Profiling of Patient-derived Prostate Tumor Explants. Mol Cell Proteomics. 2018;17:1470-1486 pubmed publisher
    ..Also, 17-AAG treatment led to increased expression of DNAJA1 in PDEs that exhibited a cytostatic response, revealing potential drug resistance mechanisms...

More Information

Publications66

  1. Ramos P, Williams A, Ziegler J, Comeau M, Guy R, Lessard C, et al. Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis Rheum. 2011;63:2049-57 pubmed publisher
    ..38 × 10⁻⁴), the heat-shock protein DnaJ (DNAJA1 [rs10971259]; P = 6...
  2. Zhang L, Liu S, Liu N, Zhang Y, Liu M, Li D, et al. Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. Protein Cell. 2015;6:42-54 pubmed publisher
    ..proteins, including myosin heavy chain 9 (MYH9), heat shock cognate protein 70 (Hsc70), and dnaJ homolog subfamily A member 1 (DNAJA1), were verified to interact with HDAC6...
  3. Ramirez V, Krueger W, Aneskievich B. TNIP1 reduction of HSPA6 gene expression occurs in promoter regions lacking binding sites for known TNIP1-repressed transcription factors. Gene. 2015;555:430-7 pubmed publisher
    ..Under standard culture conditions, expression of several heat shock proteins, including HSPA1A, HSPA6, DNAJA1 and DNAJB1, was reduced...
  4. Bhangoo M, Tzankov S, Fan A, Dejgaard K, Thomas D, Young J. Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import. Mol Biol Cell. 2007;18:3414-28 pubmed
    ..Interestingly, three different Hsp40-related J-domain proteins were identified: DJA1, DJA2, and DJA4. The DJAs bound preproteins to different extents through their C-terminal regions...
  5. Dai W, Wang Q, Zhao F, Liu J, Liu H. Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry. BMC Genomics. 2018;19:403 pubmed publisher
    ..PSMC2, PSMC6, PSMD14, PSMA2, PSMA3) and ubiquitin-mediated protein degradation (UBE2B, UBE2H, KLHL9, HSPH1, DNAJA1 and CACYBP), and more protein disassembly-related enzymes (SEC63, DNAJC3, DNAJB1, DNAJB11 and DNAJC12)...
  6. Deane C, Brown I. Components of a mammalian protein disaggregation/refolding machine are targeted to nuclear speckles following thermal stress in differentiated human neuronal cells. Cell Stress Chaperones. 2017;22:191-200 pubmed publisher
    ..after thermal stress in differentiated human neuronal SH-SY5Y cells, namely: HSPA1A (Hsp70-1), DNAJB1 (Hsp40-1), DNAJA1 (Hsp40-4), and HSPH1 (Hsp105α)...
  7. Malheiros J, Enriquez Valencia C, da Silva Duran B, de Paula T, Curi R, de Vasconcelos Silva J, et al. Association of CAST2, HSP90AA1, DNAJA1 and HSPB1 genes with meat tenderness in Nellore cattle. Meat Sci. 2018;138:49-52 pubmed publisher
    The objective of this study was to evaluate the association of expression of CAPN1, CAPN2, CAST, HSP90AA1, DNAJA1 and HSPB1 genes with meat tenderness in Nellore cattle...
  8. Dwivedi S, Saquib Q, Al Khedhairy A, Ahmad J, Siddiqui M, Musarrat J. Rhamnolipids functionalized AgNPs-induced oxidative stress and modulation of toxicity pathway genes in cultured MCF-7 cells. Colloids Surf B Biointerfaces. 2015;132:290-8 pubmed publisher
    ..BAX, BCl2, Cyclin D1, DNAJA1, E2F transcription factor 1, GPX1 and HSPA4, associated with apoptosis signaling, proliferation and carcinogenesis,..
  9. Kwon S, Kim S, Song N, Chang S, Hwang Y, Yang D, et al. Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1. J Nutr Biochem. 2016;30:24-32 pubmed publisher
    ..of other heat shock proteins including Hsp20, Hsp27, Hsp47, Hsp70, Hsp72, and Hsp90, and another type of Hsp40 (Dnaja1)...
  10. Tebaldi T, Zaccara S, Alessandrini F, Bisio A, Ciribilli Y, Inga A. Whole-genome cartography of p53 response elements ranked on transactivation potential. BMC Genomics. 2015;16:464 pubmed publisher
    ..PDE2A, GAS6, E2F7, APOBEC3H, KCTD1, TRIM32, DICER, HRAS, KITLG and TGFA p53-dependent regulation, while MAP2K3, DNAJA1 and potentially YAP1 were identified as new direct p53 target genes...
  11. Wang T, Feugang J, Crenshaw M, Regmi N, Blanton J, Liao S. A Systems Biology Approach Using Transcriptomic Data Reveals Genes and Pathways in Porcine Skeletal Muscle Affected by Dietary Lysine. Int J Mol Sci. 2017;18: pubmed publisher
    ..to: (1) increased muscle protein degradation via the ubiquitination pathway as indicated by the up-regulated DNAJA1, HSP90AB1 and UBE2B mRNA; (2) reduced muscle protein synthesis via the up-regulated RND3 ..
  12. Pan M, Zhou Y, Wang Y, Li L, Song Y, Hou L, et al. Screening and Identification of the Host Proteins Interacting with Toxoplasma gondii Rhoptry Protein ROP16. Front Microbiol. 2017;8:2408 pubmed publisher
    ..Two mouse proteins, Dnaja1 (DnaJ heat shock protein family member A1) and Gabra4 (gamma-aminobutyric acid A receptor, subunit alpha 4) were ..
  13. Nicolini P, Amorín R, Han Y, Peñagaricano F. Whole-genome scan reveals significant non-additive effects for sire conception rate in Holstein cattle. BMC Genet. 2018;19:14 pubmed publisher
    ..Most of these regions harbor genes, such as ADAM28, DNAJA1, TBC1D20, SPO11, PIWIL3 and TMEM119, that are directly implicated in testis development, male germ line ..
  14. Shan Y, Wang D, Xu Y, Wang C, Cao L, Liu Y, et al. Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid. J Alzheimers Dis. 2016;49:829-44 pubmed publisher
    ..of chaperones were relatively lower in middle-aged mice brain; CRS further reduced the expression, especially for HDJ2/HSP40...
  15. Stark J, Mehla K, Chaika N, Acton T, Xiao R, Singh P, et al. Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry. 2014;53:1360-72 pubmed publisher
    ..The human protein DnaJ homologue subfamily A member 1 (DNAJA1) was previously shown to be downregulated 5-fold in pancreatic cancer cells and has been targeted as a biomarker ..
  16. Oh S, Iwahori A, Kato S. Human cDNA encoding DnaJ protein homologue. Biochim Biophys Acta. 1993;1174:114-6 pubmed
  17. Hernández M, Chadli A, Toft D. HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. J Biol Chem. 2002;277:11873-81 pubmed
    ..These results indicate that HSP40 initiates the entry of PR into the HSP90 pathway. ..
  18. Jana N, Tanaka M, Wang G, Nukina N. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum Mol Genet. 2000;9:2009-18 pubmed
    ..Overexpression of Hdj-1 and Hsc70 is also able to protect cell death caused by polyglutamine-expanded tNhtt and their combination proved to be most effective. ..
  19. Tzankov S, Wong M, Shi K, Nassif C, Young J. Functional divergence between co-chaperones of Hsc70. J Biol Chem. 2008;283:27100-9 pubmed publisher
    ..We analyzed the purified Hsp40-related co-chaperones DJA1 (Hdj2) and DJA2 (Hdj3) and found that they had a distinct pattern of binding to a range of polypeptides...
  20. Marschang P, Brich J, Weeber E, Sweatt J, Shelton J, Richardson J, et al. Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol. 2004;24:3782-93 pubmed
    ..Analysis of LRP1b knockout mice may provide further insights into the role of LRP1b as a tumor suppressor and into the mechanisms of cancer development. ..
  21. Hu Y, Zhou Z, Huang X, Xu M, Lu L, Xu Z, et al. Expression of a novel DnaJA1 alternative splicing in human testis and sperm. Int J Androl. 2004;27:343-9 pubmed
    ..at expression level between adult and embryo human testes was named nDnaJA1 (a new alternative isoform of human DnaJA1 which was also named HDJ2/Hsdj/dj2, a human HSP40 homologue), which was believed to be involved in testis ..
  22. Bao Y, Cook L, O Donovan D, Uyama E, Rubinsztein D. Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy. J Biol Chem. 2002;277:12263-9 pubmed
  23. Cao M, Wei C, Zhao L, Wang J, Jia Q, Wang X, et al. DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity. J Virol. 2014;88:14078-89 pubmed publisher
    ..In this study, we newly identified host factor DnaJA1, a member of the type I DnaJ/Hsp40 family, acting as a positive regulator for influenza virus replication...
  24. Rauch J, Gestwicki J. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014;289:1402-14 pubmed publisher
    ..Finally, we combined the Hsp70-NEF pairs with cochaperones of the J protein family (DnaJA1, DnaJA2, DnaJB1, and DnaJB4) to generate 16 permutations...
  25. Meacham G, Patterson C, Zhang W, Younger J, Cyr D. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol. 2001;3:100-5 pubmed
    ..CHIP is a co-chaperone that converts Hsc70 from a protein-folding machine into a degradation factor that functions in endoplasmic-reticulum quality control. ..
  26. Pei L. Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. J Biol Chem. 1999;274:3151-8 pubmed
    ..One of the clones is the ribosomal protein S10, the other encodes a novel human DnaJ homologue designated HSJ2. Northern blot analysis showed that testis contains higher levels of HSJ2 mRNA than other tissues examined, and the ..
  27. Orthwein A, Zahn A, Methot S, Godin D, Conticello S, Terada K, et al. Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. EMBO J. 2012;31:679-91 pubmed publisher
    ..We describe a specific functional interaction between AID and the Hsp40 DnaJa1, which provides insight into the function of both proteins...
  28. Choi H, Lee S, Kim K, Hwang C, Lee Y, Chae S, et al. Redox-regulated cochaperone activity of the human DnaJ homolog Hdj2. Free Radic Biol Med. 2006;40:651-9 pubmed
    The human DnaJ homolog Hdj2 is a cochaperone containing a cysteine-rich zinc finger domain...
  29. Mitsui K, Nakayama H, Akagi T, Nekooki M, Ohtawa K, Takio K, et al. Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins. J Neurosci. 2002;22:9267-77 pubmed
    ..Moreover, the rate of aggregate formation decreased in both transfectants. Our study suggests that both EF-1alpha and HSP84 are involved in the neurodegenerative process of polyglutamine diseases. ..
  30. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser M, et al. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proc Natl Acad Sci U S A. 2015;112:15372-7 pubmed publisher
  31. Walker V, Wong M, Atanasiu R, Hantouche C, Young J, Shrier A. Hsp40 chaperones promote degradation of the HERG potassium channel. J Biol Chem. 2010;285:3319-29 pubmed publisher
    ..Here, we identify the Hsp40 type 1 chaperones DJA1 (DNAJA1/Hdj2) and DJA2 (DNAJA2) as key modulators of hERG degradation...
  32. Davis A, Alevy Y, Chellaiah A, Quinn M, Mohanakumar T. Characterization of HDJ-2, a human 40 kD heat shock protein. Int J Biochem Cell Biol. 1998;30:1203-21 pubmed
    ..Thus, our study shows the characterization of a HSP which, because of its migration pattern upon heat shock, is an excellent candidate for a protein chaperon. ..
  33. Borges J, Fischer H, Craievich A, Ramos C. Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures. J Biol Chem. 2005;280:13671-81 pubmed
    ..x-ray scattering and analytical ultracentrifugation to study two representatives of human Hsp40, namely, DjA1 (Hdj2/dj2/HSDJ/Rdj1) from subfamily A and DjB4 (Hlj1/DnaJW) from subfamily B, and to determine their quaternary structure...
  34. Yang C, Miao S, Zong S, Koide S, Wang L. Identification and characterization of rDJL, a novel member of the DnaJ protein family, in rat testis. FEBS Lett. 2005;579:5734-40 pubmed
    ..The present findings suggest that rDJL functions as co-chaperone to Hsc70, participates in vesicular trafficking and may play an important role in acrosomogenesis. ..
  35. Urano E, Morikawa Y, Komano J. Novel role of HSP40/DNAJ in the regulation of HIV-1 replication. J Acquir Immune Defic Syndr. 2013;64:154-62 pubmed publisher
    ..This is the first report providing evidence that HSP70-HSP40 complex confers an innate resistance specific to HIV-1. For their interferon-inducible nature, HSP40 family members should account for the anti-HIV-1 function of interferon. ..
  36. Wang R, Huang Y, Chong K, Hung C, Ke Z, Chang R. DnaJ homolog Hdj2 facilitates Japanese encephalitis virus replication. Virol J. 2011;8:471 pubmed publisher
    ..Host factors involved in JEV replication are not well characterized. We identified Hdj2, a heat-shock protein 40 (Hsp40)/DnaJ homolog, from a mouse brain cDNA library interacting with JEV nonstructural ..
  37. Rubenstein R, Zeitlin P. Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR. Am J Physiol Cell Physiol. 2000;278:C259-67 pubmed
    ..Levels of immunoreactive Hsp40, Hdj2, Hsp70, Hsp90, and calnexin were unaffected by 4PBA treatment...
  38. Meacham G, Lu Z, King S, Sorscher E, Tousson A, Cyr D. The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. EMBO J. 1999;18:1492-505 pubmed
    ..A putative step in the CFTR folding pathway catalyzed by Hdj-2/Hsc70 is the formation of an intramolecular NBD1-R-domain complex. Whether this step is defective in the biogenesis of DeltaF508 CFTR will be discussed. ..
  39. Parrales A, Thoenen E, Iwakuma T. The interplay between mutant p53 and the mevalonate pathway. Cell Death Differ. 2018;25:460-470 pubmed publisher
    ..CHIP ubiquitin ligase-mediated degradation of conformational mutp53 by inhibiting interaction between mutp53 and DNAJA1, a Hsp40 family member. Thus, the mevalonate pathway contributes to mutp53 stabilization...
  40. Walker V, Atanasiu R, Lam H, Shrier A. Co-chaperone FKBP38 promotes HERG trafficking. J Biol Chem. 2007;282:23509-16 pubmed
    ..We propose that FKBP38 is a co-chaperone of HERG and contributes via the Hsc70/Hsp90 chaperone system to the trafficking of wild type and mutant HERG potassium channels. ..
  41. Chellaiah A, Davis A, Mohanakumar T. Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein. Biochim Biophys Acta. 1993;1174:111-3 pubmed
    ..HDJ-2 shares significant homology with Escherichia coli heat shock protein DNAJ, as well as the yeast homologues Sec63, YDJ1, SCJ1 and SIS1. This homology suggests HDJ-2 may be involved in protein folding and/or transport. ..
  42. Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama K, et al. CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell. 2002;10:55-67 pubmed
    ..Furthermore, CHIP enhanced the ability of Parkin to inhibit cell death induced by Pael-R. Taken together, these results indicate that CHIP is a mammalian E4-like molecule that positively regulates Parkin E3 activity. ..
  43. Parrales A, Ranjan A, Iyer S, Padhye S, Weir S, Roy A, et al. DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. Nat Cell Biol. 2016;18:1233-1243 pubmed publisher
    ..ligase-mediated nuclear export, ubiquitylation, and degradation of mutp53 by impairing interaction of mutp53 with DNAJA1, a Hsp40 family member...
  44. Hanai R, Mashima K. Characterization of two isoforms of a human DnaJ homologue, HSJ2. Mol Biol Rep. 2003;30:149-53 pubmed
    Two cDNA forms were characterized for a human dnaJ homologue, HSJ2. Nucleotide sequencing showed that the gene product HSJ2 was longer than previously reported, extending its homology to other human DnaJ paralogues, and that the two cDNAs ..
  45. Zeruth G, Williams J, Cole Y, Jetten A. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PLoS ONE. 2015;10:e0131303 pubmed publisher
  46. Roder K, Werdich A, Li W, Liu M, Kim T, Organ Darling L, et al. RING finger protein RNF207, a novel regulator of cardiac excitation. J Biol Chem. 2014;289:33730-40 pubmed publisher
    ..Taken together, the evidence is strong that RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner. ..
  47. Xu W, Liu L, Hornby D. c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway. Molecules. 2012;17:12086-101 pubmed publisher
    ..The novel pathway described here will open new avenues for exploring novel disease treatments. ..
  48. Dziuba N, Ferguson M, O Brien W, Sanchez A, Prussia A, McDonald N, et al. Identification of cellular proteins required for replication of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses. 2012;28:1329-39 pubmed
    ..Several genes regulating diverse pathways were found to be required for HIV-1 replication, including DHX8, DNAJA1, GTF2E1, GTF2E2, HAP1, KALRN, UBA3, UBE2E3, and VMP1...
  49. Hageman J, van Waarde M, Zylicz A, Walerych D, Kampinga H. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Biochem J. 2011;435:127-42 pubmed publisher
  50. Meshalkina D, Shevtsov M, Dobrodumov A, Komarova E, Voronkina I, Lazarev V, et al. Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells. Oncotarget. 2016;7:22050-63 pubmed publisher
    ..we knocked down the expression of Hsp70 (HSPA1A) and its two most abundant co-chaperones, Hdj1 (DNAJB1) and Hdj2 (DNAJA1) in a C6 rat glioblastoma cell line...
  51. Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. J Biol Chem. 2003;278:51901-10 pubmed
    ..These data suggest that Glup may play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson's disease. ..
  52. Zheng G, Yang Y. ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation. J Biol Chem. 2004;279:42410-21 pubmed
    ..These results suggest that ZNF76 functions as a transcriptional repressor through its interaction with TBP and that sumoylation modulates its transcriptional repression activity. ..
  53. Terada K, Mori M. Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. J Biol Chem. 2000;275:24728-34 pubmed
    DnaJ is an essential cochaperone of mammalian heat shock cognate 70 (hsc70) protein. We previously found that dj2 (HSDJ/hdj-2/rdj1), rather than dj1 (hsp40/hdj-1), is a partner DnaJ for the hsc70-based chaperone system...
  54. Sun L, Prince T, Manjarrez J, Scroggins B, Matts R. Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012;1823:1092-101 pubmed publisher
    ..Aha1 complexes isolated from HeLa cell extracts also contained Hsp70 and DNAJA1. Over-expression of Aha1 has been reported to stimulate the activity of v-Src and steroid hormone receptors ..
  55. Abisambra J, Jinwal U, Suntharalingam A, Arulselvam K, Brady S, Cockman M, et al. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau. J Mol Biol. 2012;421:653-61 pubmed publisher
    ..In particular, over-expression of the constitutive DnaJ, DnaJA1, mediated tau clearance, while knockdown facilitated tau accumulation...
  56. Gao Y, Yechikov S, Vazquez A, Chen D, Nie L. Distinct roles of molecular chaperones HSP90? and HSP90? in the biogenesis of KCNQ4 channels. PLoS ONE. 2013;8:e57282 pubmed publisher
    ..KCNQ4 surface expression was restored by HSP90? in cells mimicking heterozygous conditions of the DFNA2 patients, even though it was not sufficient to rescue the function of KCNQ4 channels. ..
  57. Sen S, Webber P, West A. Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. J Biol Chem. 2009;284:36346-56 pubmed publisher