Genomes and Genes
Gene Symbol: DNAI1
Description: dynein, axonemal, intermediate chain 1
Alias: CILD1, DIC1, ICS, ICS1, PCD, axonemal dynein intermediate chain 1, dynein intermediate chain 1, axonemal, dynein intermediate chain DNAI1, dynein, axonemal, intermediate polypeptide 1, immotile cilia syndrome 1
Publications147 found, 100 shown here
- EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior oliveT E Milner
Departement de Physiologie, Universite de Montreal, Quebec, Canada
J Neurophysiol 73:2568-77. 1995..wild-type) mice (+/+), as well as five lurcher (lc/+), six nervous (nr/nr), and eight Purkinje cell degeneration (pcd/pcd) mutants were implanted with chronic electromyogram (EMG) electrodes in the hamstring and quadriceps muscle ..
- Assessment of erythrocyte shape by flow cytometry techniquesM Piagnerelli
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
J Clin Pathol 60:549-54. 2007..Several techniques are available to assess alterations in RBC rheology, especially deformability, but they are too cumbersome to be used on a large number of cells...
- DNAI1 mutations explain only 2% of primary ciliary dykinesiaMike Failly
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
Respiration 76:198-204. 2008..To date, 5 genes encoding 3 dynein protein arm subunits (DNAI1, DNAH5 and DNAH11), the kinase TXNDC3 and the X-linked RPGR have been found to be mutated in PCD.
- Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesiaM Zariwala
Department of Medicine, University of North Carolina at Chapel Hill, USA
Am J Respir Cell Mol Biol 25:577-83. 2001..Mutations in an intermediate chain dynein (DNAI1; IC78) have recently been described in PCD patients, with outer dynein arm (ODA) defects...
- Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome)C Guichard
Laboratoire de Génétique Moléculaire Humaine, Equipe d Accueil 3088, Université C Bernard Lyon 1, 69373 Lyon Cedex 8, France
Am J Hum Genet 68:1030-5. 2001..The axonemal dynein intermediate-chain gene 1 (DNAI1), which has been demonstrated to be responsible for a case of primary ciliary dyskinesia (PCD) without situs ..
- Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutationMaimoona A Zariwala
University of North Carolina at Chapel Hill 27599 7248, USA, and Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Germany
Am J Respir Crit Care Med 174:858-66. 2006..Disease-causing mutations have been reported in DNAI1 and DNAH5 encoding outer dynein arm (ODA) proteins of cilia.
- Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesiaG Pennarun
Institut National de la Santé et de la Recherche Médicale U468, Hopital Henri Mondor, 94010 Creteil, France
Am J Hum Genet 65:1508-19. 1999..advantage of the evolutionary conservation of genes encoding axonemal proteins, we have isolated a human sequence (DNAI1) related to IC78, a C...
- Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cellsM Shimizu
Department of Psychiatry and Neuroscience, Kure National Hospital, Japan
Br J Pharmacol 114:1282-8. 1995..AMP accumulation in amitriptyline-treated cells was attenuated by the 5-HT4 receptor antagonists, GR 113808 and ICS 205-930, with relatively low potency...
- Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptorJ K Ward
Department of Thoracic Medicine, National Heart and Lung Institute, London
Br J Pharmacol 111:1095-102. 1994..1 microM), the 5-HT1A/B antagonist, cyanopindolol (1 microM) or the 5-HT3/4 antagonist, ICS 205-930 (1 microM). 4. Methiothepin (0.1 microM) produced an insurmountable inhibition of the effect of 5-HT (0...
- Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysisDiana M Sobieraj
University of Connecticut School of Pharmacy, Storrs, Connecticut, USA
Clin Ther 30:1416-25. 2008Several clinical trials have evaluated the benefits associated with adding an inhaled corticosteroid (ICS) to a long-acting bronchodilator in the treatment of severe or very severe (stage III or IV) chronic obstructive pulmonary disease (..
- Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atriumA D Medhurst
SmithKline Beecham Pharmaceuticals, The Pinnacles, Harlow, Essex
Br J Pharmacol 110:1023-30. 1993..3.The affinity of SB 203186 was approximately 20 times higher than that of tropisetron (ICS 205-930;pKB= 6.9) and DAU 6215 (pKB= 7.0)...
- Mediation by 5-HT1D receptors of 5-hydroxytryptamine-induced contractions of rabbit middle and posterior cerebral arteriesV Deckert
Laboratoires Fournier, Daix, France
Br J Pharmacol 112:939-45. 1994..4. In both arteries, the contraction-response curve to 5-HT was unaffected by the 5-HT3 receptor antagonist, ICS 205-930 (0.01 and 0.1 microM) whilst a small (3 and 6 fold displacement) was seen with MDL 72222 (0.1 and 1 microM)...
- Microtubular discontinuities as acquired ciliary defects in airway epithelium of patients with chronic respiratory diseasesJ L Carson
Department of Pediatrics and Cell Biology and Anatomy, University of North Carolina at Chapel Hill
Ultrastruct Pathol 18:327-32. 1994..cilia characterized by microtubular discontinuities and previously associated with primary ciliary dyskinesia (PCD) has been documented in other forms of chronic airways diseases, including cystic fibrosis (CF)...
- [Primary ciliary dyskinesia in situs inversus without bronchiectasis]J Gierich
, Fachkliniken Wangen,
Pneumologie 51:1127-32. 1997..In adults suffering from Kartagener's syndrome-which is found in 50% of patients with primary ciliary dyskinesia (PCD)-bronchiectasis is still one of three typical clinical features...
- In-situ end labelling with bromodeoxyuridine--an advanced technique for the visualization of apoptotic cells in histological specimensA Aschoff
, , Germany
Horm Metab Res 28:311-4. 1996The fragmentation of nuclear DNA is considered to be a biochemical indication of programmed cell death (PCD) in various tissues...
- Characterization of 5-HT3 receptors of N1E-115 neuroblastoma cells by use of the influx of the organic cation [14C]-guanidiniumH Bonisch
Institut fur Pharmakologie und Toxikologie, Universitat Bonn, Germany
Br J Pharmacol 108:436-42. 1993..ketanserin (10 microM) but was inhibited by 5-HT3 receptor antagonists with the following rank order of potency: ICS 205-930 > ondansetron > MDL 72222 >> metoclopramide. 5...
- Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balanceD Promeneur
Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark
Am J Physiol Renal Physiol 279:F1014-26. 2000In the rat, aquaporin-6 (AQP6) is mainly localized in intercalated cells (ICs) in collecting ducts, where it is exclusively associated with intracellular vesicles...
- Characterization of 5-hydroxytryptamine receptors mediating mucosal secretion in guinea-pig ileumP J Johnson
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
Br J Pharmacol 111:1240-4. 1994..nM), TTX (300 nM), ketanserin (3-300 nM) and also by the 5-HT3 receptor antagonists, granisetron (1 microM) and ICS 205-930 (100 nM). 5...
- An anatomical classification--a new paradigm for management of urinary dysfunction in the femaleP E Papa Petros
Royal Perth Hospital, Western Australia
Int Urogynecol J Pelvic Floor Dysfunct 10:29-35. 1999..This convergence in anatomical and urodynamic (ICS) concepts explains many previously unexplained phenomena, and potentially opens up an entirely new approach to ..
- Correlations between ciliary structure and ciliary functionT Willems
ENT Department, UZ GHB, Leuven, Belgium
Acta Otorhinolaryngol Belg 54:299-308. 2000..COR), coordinated ciliary activity and ciliary immotility were investigated based on the findings in over 700 non-PCD biopsies taken in the context of diagnostic investigations for respiratory problems...
- Evaluation of the utilization patterns of leukotriene modifiers in a large managed care health planPaul G Lakomski
Excellus Health Plan, Inc, 344 South Warren St, Syracuse, NY 13202, USA
J Manag Care Pharm 10:115-21. 2004..of leukotriene modifiers (LM) relative to national guidelines and to investigate possible emergency room utilization differences for LMs as monotherapy versus inhaled corticosteroid (ICS) monotherapy or combination ICS and LM therapy.
- Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in children under the age of 12 yearsC Main
Peninsula Technology Assessment Group PenTAG, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, UK
Health Technol Assess 12:1-174, iii-iv. 2008To assess the clinical and cost-effectiveness of inhaled corticosteroids (ICS) alone and ICS used in combination with a long-acting beta2 agonist (LABA) in the treatment of chronic asthma in children aged under 12 years.
- 5-Hydroxytryptamine (5-HT) mediates potent relaxation in the sheep isolated pulmonary vein via activation of 5-HT4 receptorsT M Cocks
Baker Medical Research Institute, Prahran, Victoria, Australia
Br J Pharmacol 107:591-6. 1992..5. ICS 205-930 (1-10 microM) competitively antagonized the concentration-relaxation curve to 5-HT with a pA2 of ..
- Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cellsLinda Mathsson
Unit of Clinical Immunology, Uppsala University, Uppsala, Sweden
Arthritis Res Ther 8:R64. 2006Immune complexes (ICs) can induce production of cytokines by peripheral blood mononuclear cells via Fc receptors. Rheumatoid factor (RF) develop in response to ICs in many clinical and experimental settings...
- Programmed death in bacteriaK Lewis
Biotechnology Center, Tufts University, Medford, Massachusetts 02155, USA
Microbiol Mol Biol Rev 64:503-14. 2000Programmed cell death (PCD) in bacteria plays an important role in developmental processes, such as lysis of the mother cell during sporulation of Bacillus subtilis and lysis of vegetative cells in fruiting body formation of Myxococcus ..
- Regulation of ion and water transport across the eel intestine: effects of acetylcholine and serotoninY Mori
Faculty of Integrated Arts and Sciences, Hiroshima University, Japan
J Comp Physiol B 161:387-92. 1991..These inhibitory effects of ACh and 5-HT were blocked by atropine, a muscarinic receptor antagonist, and ICS-205930, a 5-HT3 receptor antagonist, respectively...
- Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthmaFrancine M Ducharme
Research Centre, CHU Sainte Justine and the Department of Pediatrics, University of Montreal, 3175 Cote Sainte Catherine, Montreal, , Canada, H3T 1C5
Cochrane Database Syst Rev 4:CD005533. 2010..options are recommended: the combination of a long-acting inhaled ss2 agonist (LABA) with inhaled corticosteroids (ICS) or use of a higher dose of inhaled corticosteroids...
- Cost-effectiveness of budesonide/formoterol for maintenance and reliever asthma therapy in Denmark--cost-effectiveness analysis based on five randomised controlled trialsJannie Wickstrøm
MUUSMANN COWI, Kolding, Denmark
Clin Respir J 3:169-80. 2009..to determine the cost-effectiveness of the Symbicort SMART regime in Denmark vs higher dose inhaled corticosteroid (ICS) plus reliever medication, similar dose inhaled corticosteroid/long-acting beta(2)-agonist (ICS/LABA) combination ..
- Prevention of nausea and vomiting in cisplatin-treated patients by a selective 5-hydroxytryptamine (5-HT3) receptor antagonist, ICS 205-930L Dogliotti
Department of Clinical and Biological Sciences, University of Torino, Italy
Tumori 76:595-8. 1990..study designed to evaluate the prevention of cisplatin-induced emesis by the specific 5-HT3 receptor antagonist ICS 205-930 are reported...
- A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthmaJean Bousquet
Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, France
Clin Ther 24:1-20. 2002Although inhaled corticosteroids (ICS) are commonly used in the treatment of persistent asthma, the relationship between dose and clinical response remains unclear.
- 111In-labeled immunoconjugates (ICs) bispecific for the epidermal growth factor receptor (EGFR) and cyclin-dependent kinase inhibitor, p27Kip1Bart Cornelissen
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
Cancer Biother Radiopharm 24:163-73. 2009..Our aim was to construct immunoconjugates (ICs) bispecific for epidermal growth factor receptors (EGFRs) and the intranuclear cyclin-dependent kinase inhibitor (..
- Inhibition of translation initiation on Escherichia coli gnd mRNA by formation of a long-range secondary structure involving the ribosome binding site and the internal complementary sequenceJ T Chang
Department of Biological Sciences, University of Maryland Baltimore County 21228, USA
J Bacteriol 177:6560-7. 1995..growth rate-dependent regulation of Escherichia coli gnd expression involves the internal complementary sequence (ICS), a negative control site that lies within the 6-phosphogluconate dehydrogenase coding sequence...
- Diverse effects of Purkinje cell loss on deep cerebellar and vestibular nuclei neurons in Purkinje cell degeneration mutant mice: a possible compensatory mechanismJ Bäurle
Department of Physiology, Freie Universitat Berlin, Fachbereich Humanmedizin, Universitatsklinikum Benjamin Franklin, Germany
J Comp Neurol 384:580-96. 1997The genetic defect in the Purkinje cell degeneration (PCD) mutant mouse completely disrupts the cerebellar corticonuclear connection through intrinsic action on the final integrating unit of the cerebellar cortex, the Purkinje cell (PC)...
- Blockade of 5-HT3 receptor-mediated currents in dissociated frog sensory neurones by benzoxazine derivative, Y-25130T Yakushiji
Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd, Japan
Br J Pharmacol 107:853-7. 1992..The 5-HT response was reversibly antagonized by the 5-HT3 receptor antagonists, ICS 205-930, metoclopramide and Y-25130, but not by a 5-HTIA receptor antagonist, spiperone, and a 5-HT2 receptor ..
- An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genesP H Driggers
Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 87:3743-7. 1990..transcription of major histocompatibility complex (MHC) class I genes through the conserved IFN consensus sequence (ICS) that contains an IFN response motif shared by many IFN-regulated genes...
- Effects of 5-HT(3) receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) ratsZ A Rodd-Henricks
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
Alcohol 21:73-85. 2000..The current experiments were conducted to examine the effects of the 5-HT(3) antagonists MDL 72222 (MDL) or ICS 205-930 (ICS) on 24-h ethanol (10% v/v) consumption during acquisition, maintenance, and following a period of ..
- Inhibiting effects of serotonin and serotonin antagonists on the migration of mononuclear leucocytesL Bondesson
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
Immunopharmacol Immunotoxicol 15:243-50. 1993The effect of serotonin and the serotonin antagonists ketanserin, methiotepine and ICS-205-930 on the migration of leucocytes was studied by using the sealed capillary migration technique...
- Necrosis is an active and controlled form of programmed cell deathS Ya Proskuryakov
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249020, Russia
Biochemistry (Mosc) 67:387-408. 2002In all studies on programmed cell death (PCD) and apoptosis as its most showy form, this process was considered to be a paradigmatic antithesis to necrotic cell death...
- Regular use of corticosteroids and low use of short-acting beta2-agonists can reduce asthma hospitalizationAmbikaipakan Senthilselvan
Department of Public Health Sciences, University of Alberta, 13 106B Clinical Sciences Building, Edmonton, AL, Canada, T6G 2G3
Chest 127:1242-51. 2005Inhaled corticosteroids (ICS) and inhaled short-acting beta(2)-agonists (ISABA) are the most commonly used medications for management of asthma...
- Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesiaJ Neesen
Institute of Human Genetics, University of Gottingen, Germany
Cytogenet Genome Res 98:38-44. 2002Primary ciliary dyskinesia (PCD) is a heterogeneous autosomal recessive disease that is caused by impaired ciliary and flagellar functions. About 50% of PCD patients show situs inversus, denoted as Kartagener syndrome...
- Safety of inhaled budesonide: clinical manifestations of systemic corticosteroid-related adverse effectsCamilla Christensson
Patient Safety, Clinical Development, AstraZeneca R and D Lund, Lund, Sweden
Drug Saf 31:965-88. 2008Inhaled corticosteroid (ICS) therapy is central to the long-term management of asthma and is extensively used in the management of chronic obstructive pulmonary disease (COPD)...
- Sites of action of mu-, kappa- and sigma-opiate receptor agonists at the feline ileocecal sphincterA Ouyang
Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104
Am J Physiol 254:G224-31. 1988The sites of action of several opiate agonists at the feline ileocecal sphincter (ICS) were studied...
- Is there a role for inhaled corticosteroids and macrolide therapy in bronchiectasis?Paul King
Monash University, Department of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia
Drugs 67:965-74. 2007..Two potentially useful therapies are inhaled corticosteroids (ICS) and macrolides...
- Removal of As(III) in a column reactor packed with iron-coated sand and manganese-coated sandYoon Young Chang
Department of Environmental Engineering, Kwangwoon University, Seoul 139 701, Republic of Korea
J Hazard Mater 150:565-72. 2008The applicability of manganese-coated sand (MCS) and iron-coated sand (ICS) for the treatment of As(III) via oxidation and adsorption processes was investigated...
- Alternative splicing and gene duplication differentially shaped the regulation of isochorismate synthase in Populus and ArabidopsisYinan Yuan
School of Forest Resources and Environmental Science, Michigan Technological University, Houghton, MI 49931, USA
Proc Natl Acad Sci U S A 106:22020-5. 2009Isochorismate synthase (ICS) converts chorismate to isochorismate for the biosynthesis of phylloquinone, an essential cofactor for photosynthetic electron transport...
- Deregulated sequential motion of centromeres induced by antitumor agents may lead to genome instability in human peripheral blood lymphocytesV Bajic
Institute for Biomedical Research, Galenika a d, Belgrade, Serbia
J BUON 12:77-83. 2007..Alteration of the sequence of centromere separation or premature centromere division (PCD) has been found to be significantly higher in populations exposed to various xenobiotics...
- Administrative claims analysis of asthma-related health care utilization for patients who received inhaled corticosteroids with either montelukast or salmeterol as combination therapyFelicia C Allen-Ramey
Merck and Co, Sumneytown Pike, WP39 170, West Point, PA 19486 0004, USA
J Manag Care Pharm 12:310-21. 2006..a matched cohort of asthma patients using inhaled corticosteroids (ICSs) plus either montelukast (MON) or salmeterol (SAL) as combination therapy for asthma, during a time prior to the availability of fixed-dose combinations of ICS/SAL.
- Chloroplast and reactive oxygen species involvement in apoptotic-like programmed cell death in Arabidopsis suspension culturesSiamsa M Doyle
School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
J Exp Bot 61:473-82. 2010..ROS are known to act as regulators of programmed cell death (PCD) in plant and animal cells, so it is possible that chloroplasts have a role in regulating PCD in green tissue...
- Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) ratsZachary A Rodd
Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indianapolis, USA
Alcohol 44:245-55. 2010..Instruments, Allentown, PA) were used to examine the effects of seven consecutive bilateral microinfusions of ICS 205-930 (ICS), a 5-HT(3) receptor antagonist, directly into the posterior VTA on the acquisition and maintenance of ..
- ICS 205-930 reduces 5-methoxytryptamine-induced short-circuit current in stripped pig jejunumM B Hansen
Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
Can J Physiol Pharmacol 72:227-32. 1994The effect of ICS 205-930 on serotonin (5-hydroxytryptamine, 5-HT) and 5-methoxytryptamine (5-MeOT) induced short-circuit current (SCC) was studied in muscle-stripped pig jejunum in vitro...
- The secondary nature of ciliary (dis)orientation in secondary and primary ciliary dyskinesiaMark Jorissen
Department of ENT, Head and Neck Surgery, University Hospital Leuven, Leuven, Belgium
Acta Otolaryngol 124:527-31. 2004..secondary ciliary dyskinesia (SCD)] and in a very few cases as the single abnormality in primary ciliary dyskinesia (PCD). The etiology, pathogenesis, consequences and relevance of ciliary (dis)orientation are still unclear.
- Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and futureKian Fan Chung
Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
Eur J Clin Pharmacol 65:853-71. 2009Inhaled corticosteroid (ICS) therapy in combination with long-acting beta-adrenergic agonists represents the most important treatment for chronic airways diseases such as asthma and chronic obstructive pulmonary disease (COPD)...
- Impact of inhaled corticosteroid-induced oropharyngeal adverse events: results from a meta-analysisGary S Rachelefsky
Allergy Research Foundation Inc, UCLA School of Medicine, Los Angeles, California 90025, USA
Ann Allergy Asthma Immunol 98:225-38. 2007Oropharyngeal adverse events associated with inhaled corticosteroid (ICS) use can affect adherence; however, these effects have been studied less extensively than those that occur systemically.
- Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic studyC Strazielle
Centre de Recherche en Sciences Neurologiques, Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
Neuroscience 94:287-304. 1999The mouse "Purkinje cell degeneration" (pcd) is characterized by a primary loss of Purkinje cells, as well as by retrograde and secondary partial degeneration of cerebellar granule cells and inferior olivary neurons; this ..
- Benefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroidsD C Grootendorst
Dutch Asthma Centre, Davos, Switzerland
Clin Exp Allergy 31:400-8. 2001Some patients with severe asthma cannot be controlled with high doses of inhaled steroids (ICS), which may be related to ongoing environmental allergen exposure...
- Inhaled corticosteroids in children: use and effects of early treatment on asthma and lung function. Prevalence of asthma and the impact of severity in early life on later asthma in childhoodChandra Sekhar Devulapalli
Department of Paediatrics, Ringerike Hospital, Hønefoss, Norway
Clin Respir J 2:247-8. 2008The role of inhaled corticosteroids (ICS) on disease progression in asthmatic children is not yet clear.
- Inter-crystal scatter in a dual layer, high resolution LSO-APD positron emission tomographM Rafecas
Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22 81675 München, Germany
Phys Med Biol 48:821-48. 2003..multiple signals related to those photons scattering between different crystal units (inter-crystal scatter, ICS). The contribution of ICS events can significantly increase the system efficiency...
- Association between previous health care use and initiation of inhaled corticosteroid and long-acting beta2-adrenergic agonist combination therapy among US patients with asthmaChristopher M Blanchette
Division of Clinical and Outcomes Research, Lovelace Respiratory Research Institute, Kannapolis, North Carolina 287081, USA
Clin Ther 31:2574-83. 2009Combination inhaled corticosteroid and long-acting beta(2)-adrenergic agonist (ICS/LABA) therapy is recommended for patients whose asthma is not adequately controlled by other maintenance therapies and for those with moderate to severe ..
- Soluble LDL-immune complexes in type 2 diabetes and vascular diseaseZ Turk
Vuk Vrhovac University Clinic for Diabetes, Dugi dol 4a, 10000 Zagreb
Horm Metab Res 34:196-201. 2002..The objective of our study was to analyse markers of LDL oxidation-soluble LDL containing immune complexes (LDL-ICs) in type 2 diabetes with micro- and macrovascular disease.
- Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the NetherlandsT W de Vries
Department of Pediatrics, Medical Centre Leeuwarden, P O Box 888, 8901 BR Leeuwarden, The Netherlands
Eur J Clin Pharmacol 62:343-6. 2006Inhaled corticosteroids (ICS) are widely used in the treatment of asthma. We studied the suspected adverse drug reactions (sADRs) reported during the use of ICS in the Netherlands.
- Patterns and determinants of compliance with inhaled steroids in adults with asthmaYves Lacasse
Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Ste Foy, Qubec, Canada
Can Respir J 12:211-7. 2005Patient compliance with inhaled corticosteroids (ICS) in asthma is considered to be suboptimal.
- Living with primary ciliary dyskinesia: a prospective qualitative study of knowledge sharing, symptom concealment, embarrassment, mistrust, and stigmaSimon Whalley
Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK
BMC Pulm Med 6:25. 2006Primary ciliary dyskinesia (PCD) is a chronic respiratory disease for which there is little psycho-social research and no qualitative studies of individuals living with the condition...
- Effects on resource utilization of adding salmeterol in combination or separately to inhaled corticosteroidsJames Chan
Pharmacy Outcomes Research Group, Kaiser Permanente Medical Care Program, 1800 Harrison, 13th Fl, Oakland, CA 94612, USA
J Manag Care Pharm 13:21-7. 2007The addition of a long-acting beta-agonist (LABA) to an inhaled corticosteroid (ICS) for patients with moderate or severe persistent asthma improves outcomes such as pulmonary function, reduces exacerbations requiring oral steroids, and ..
- Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthmaR Buhl
Pulmonary Department, Mainz University Hospital, Mainz, Germany
Curr Med Res Opin 23:1867-78. 2007An inhaled corticosteroid (ICS) or an ICS/long-acting beta(2)-agonist (LABA) combination plus short-acting beta(2)-agonist (SABA) as needed for symptom relief is recommended for persistent asthma...
- A comparison of the risk of hospitalizations due to chronicobstructive pulmonary disease in medicaid patients with various medication regimens, including ipratropium, inhaled corticosteroids, salmeterol, or their combinationKaren L Rascati
College of Pharmacy, University of Texas at Austin, Austin, Texas 78712 0127, USA
Clin Ther 27:346-54. 2005..The aim of this study was to compare the risk of hospitalizations related to chronic obstructive pulmonary disease (COPD) among Medicaid patients prescribed various medication regimens...
- Sonographically guided percutaneous catheter drainage versus needle aspiration in the management of pyogenic liver abscessEnver Zerem
Interventional Ultrasonography Department, University Clinical Center, Trnovac bb, Tuzla, Bosnia and Herzegovina
AJR Am J Roentgenol 189:W138-42. 2007The purpose of this study was to determine the effectiveness of percutaneous catheter drainage (PCD) and to compare PCD with percutaneous needle aspiration in the management of liver abscess.
- [Immunocontraceptive effect of DNA vaccines of Lagurus lagurus zona pellucida 3 fusioned with C-terminal of HSP70]Yu Zhang
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:354-7. 2008..To investigate the immunocontraceptive effect of Lagurus lagurus zona pellucida 3 gene (LZP3) fused by Mycobacterium tuberculosis HSP70 and C-terminal of HSP70...
- [Primary ciliary dyskinesia (Pcd) in Austria]Irena Lesic
Medizinische Universität Wien, Universitätsklinik für Kinder und Jugendheilkunde, Wien, Austria
Wien Klin Wochenschr 121:616-22. 2009Primary ciliary dyskinesia (PCD) is a rare hereditary recessive disease with symptoms of recurrent pneumonia, chronic bronchitis, bronchiectasis, and chronic sinusitis...
- Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysisM Bradley Drummond
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
JAMA 300:2407-16. 2008Recent studies of inhaled corticosteroid (ICS) therapy for managing stable chronic obstructive pulmonary disease (COPD) have yielded conflicting results regarding survival and risk of adverse events.
- Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinasW Li
Department of Ophthalmology, Allegheny University, Philadelphia, PA 19102, USA
Cell Mol Biol (Noisy-le-grand) 45:59-66. 1999Because programmed cell death (PCD) is an important mode of pericyte dropout in human diabetic retinopathy, whether increased oxidative stress in cells with diminished antioxidant defenses plays a causative role in the PCD process in ..
- Von Willebrand factor, fibrinogen and other risk factors of thrombosis in patients with a history of cerebrovascular ischemic stroke and their childrenM Jastrzebska
Clinical Biochemistry and Laboratory Diagnostics, Regional Center for Atherosclerosis Research, Pomeranian Academy of Medicine, Al Powstaców Wlkp 72, PL 70 111 Szczecin, Poland
Nutr Metab Cardiovasc Dis 12:132-40. 2002..We investigated whether the vWF and Fb levels in patients with ischemic cerebrovascular stroke (ICS) correlate with those in their children.
- Apoptosis: correlation of cytological changes with biochemical markers in hormone-dependent tissuesA Aschoff
Department of Anatomy II, Friedrich-Schiller-University, Jena, Germany
Horm Metab Res 29:535-43. 1997The term apoptosis, also known as programmed cell death (PCD), is used in contrast to necrotic cell death and occurs in various tissues in many different circumstances...
- Short-term use of inhaled and intranasal corticosteroids is not associated with glaucoma progression on optical coherence tomographyLenworth N Johnson
Neuro Ophthalmology Unit, Mason Eye Institute, Columbia, Missouri 65212, USA
Eur J Ophthalmol 22:695-700. 2012To compare the changes in retinal nerve fiber layer (RNFL) thickness and optic nerve cup/disc ratio on optical coherence tomography (OCT) between users and nonusers of inhaled and intranasal corticosteroids (ICS).
- Untangling the Roles of Anti-Apoptosis in Regulating Programmed Cell Death using Humanized Yeast CellsCaitlin Clapp
Department of Chemistry and Chemical Engineering, Royal Military College Kingston, ON, Canada
Front Oncol 2:59. 2012Genetically programmed cell death (PCD) mechanisms, including apoptosis, are important for the survival of metazoans since it allows, among things, the removal of damaged cells that interfere with normal function...
- Developing evidence-based standards for diagnosis and management of lower urinary tract or pelvic floor dysfunctionPeter F W M Rosier
University Medical Centre Utrecht, The Netherlands
Neurourol Urodyn 31:621-4. 2012The International Continence Society (ICS) has a key role in standardizing terminology related to lower urinary tract and pelvic organ dysfunction...
- Mutations in radial spoke head genes and ultrastructural cilia defects in East-European cohort of primary ciliary dyskinesia patientsEwa Zietkiewicz
Department of Molecular and Clinical Genetics, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
PLoS ONE 7:e33667. 2012Primary ciliary dyskinesia (PCD) is a rare (1/20,000), multisystem disease with a complex phenotype caused by the impaired motility of cilia/flagella, usually related to ultrastructural defects of these organelles...
- Markers for step-down of inhaled corticosteroid therapy in adult asthmaticsNaomi Tsurikisawa
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18 1 Sakuradai, Minami Ku, Sagamihara, Kanagawa, Japan
Allergol Int 61:419-29. 2012Background: Treatment guidelines recommend the use of inhaled corticosteroids (ICS) as first-line therapy for all stages of persistent asthma...
- Health beliefs and compliance with inhaled corticosteroids by asthmatic patients in primary care practicesC V Chambers
Department of Family Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Respir Med 93:88-94. 1999The aim of this study was to determine factors associated with regular use of inhaled corticosteroids (ICS) by asthmatic patients in primary care practices...
- Relationship between exhaled nitric oxide and IgE sensitisation in patients with asthma: influence of steroid treatmentJörgen Syk
Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Stockholm, Sweden
Clin Respir J 3:143-51. 2009The influence of the degree of immunoglobulin E (IgE) sensitisation on the fraction of expired nitric oxide (FE(NO)) in asthma patients being treated with inhaled corticosteroids (ICS) is not well known.
- Ciliary function analysis for the diagnosis of primary ciliary dyskinesia: advantages of ciliogenesis in cultureM Jorissen
Laboratory for Experimental Otorhinolaryngology, University Hospital Leuven, Belgium
Acta Otolaryngol 120:291-5. 2000The gold standard for the diagnosis of primary ciliary dyskinesia (PCD) is a dynein deficiency shown with transmission electron microscopy. However, there are many cases of PCD without dynein deficiency...
- Association between incidence of acute exacerbation and medication therapy in patients with COPDDong Churl Suh
Rutgers University School of Pharmacy, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
Curr Med Res Opin 26:297-306. 2010..study was to examine the risk of COPD-related exacerbations between groups of patients receiving inhaled corticosteroids (ICS), anticholinergics (AC), long-acting beta(2)-agonists (LABA), or fixed-dose combinations of ICS and LABA.
- 2001 Warkany lecture: to die or not to die, the role of apoptosis in normal and abnormal mammalian developmentPhilip E Mirkes
Birth Defects Research Laboratory, Division of Genetics and Development, Department of Pediatrics, University of Washington, Seattle 98195, USA
Teratology 65:228-39. 2002..Two well-known examples of programmed cell death (PCD) are the cell deaths associated with fusion of the neural folds and removal of interdigital mesenchymal cells ..
- The use of leukotriene receptor antagonists (LTRAs) as complementary therapy in asthmaL Bjermer
University Hospital, Trondheim, Norway
Monaldi Arch Chest Dis 57:76-83. 2002..Hence, the combination of an oral leukotriene receptor antagonist (LTRA) with an inhaled corticosteroid (ICS) seems a rational therapeutic approach to achieve a more complete control of the inflammatory mechanisms in asthma...
- Lung function at 10 yrs is not improved by early corticosteroid treatment in asthmatic childrenKarin C Lødrup Carlsen
Department of Paediatrics, Division of Woman and Child, Oslo University Hospital, Ulleval, Oslo, Norway
Pediatr Allergy Immunol 21:814-22. 2010Early intervention with inhaled corticosteroid (ICS) treatment for lung function development in childhood is debated. In view of lung function at birth, we aimed to assess if early use of ICS influenced lung function at 10 yrs of age...
- Ultrasound-guided percutaneous drainage may decrease the mortality of severe acute pancreatitisXinbo Ai
Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, 310009 Hangzhou, China
J Gastroenterol 45:77-85. 2010To evaluate the efficacy and safety of ultrasound-guided percutaneous catheter drainage (PCD) treatment for severe acute pancreatitis compared to conservative and conventional surgical treatments.
- Prevalence and associated factors of oropharyngeal side effects in users of inhaled corticosteroids in a real-life settingMathieu Molimard
INSERM, Unité 657, IFR 99, Bordeaux, France
J Aerosol Med Pulm Drug Deliv 23:91-5. 2010Inhaled corticosteroids (ICS) are extensively used to treat asthma, and more recently, chronic obstructive pulmonary disease (COPD)...
- Caspase-independent pathways of programmed cell death: the unraveling of new targets of cancer therapy?C Constantinou
Yasoo Health Ltd, Nicosia, Cyprus
Curr Cancer Drug Targets 9:717-28. 2009..evidence in the literature supports the existence of pathways of caspase-independent programmed cell death (CI-PCD)...
- Impact of positive and negative beliefs about inhaled corticosteroids on adherence in inner-city asthmatic patientsDiego Ponieman
Division of General Internal Medicine, Mount Sinai School of Medicine, New York, New York, USA
Ann Allergy Asthma Immunol 103:38-42. 2009Daily inhaled corticosteroid (ICS) use is the cornerstone of asthma management, although it is often suboptimal, especially in inner-city populations.
- Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic reviewFlorent Richy
WHO Collaborating Center for Public Health Aspects of Osteoarticular Disorders, Liege, Belgium
Osteoporos Int 14:179-90. 2003..effect of oral corticosteroids on bone has been well documented, whereas this remains debated for inhaled ones (ICS). Our objectives were to analyze the effects of ICS on bone mineral density, fracture risk and bone markers...
- Inhaled corticosteroid therapy for patients with persistent asthma: learnings from studies of inhaled budesonideBradley E Chipps
Capital Allergy and Respiratory Disease Center, Sacramento, California 95819, USA
Allergy Asthma Proc 30:217-28. 2009..Much knowledge about the long-term benefits of ICSs in persistent asthma stems from studies of the ICS budesonide, which have shaped current asthma guidelines...
- Effects of inhaled corticosteroids with different lung deposition on exhaled hydrogen peroxide in stable COPD patientsW J C van Beurden
Department of Pulmonology, Catharina Hospital Eindhoven, The Netherlands
Respiration 70:242-8. 2003The effects of inhaled corticosteroids (ICS) on markers of oxidative stress in patients with stable COPD are unclear.
- Effectiveness of oseltamivir in preventing influenza in household contacts: a randomized controlled trialR Welliver
The Medical Building, 327 Mile End Rd, London, England E1 4NS
JAMA 285:748-54. 2001..Influenza virus is easily spread among the household contacts of an infected person, and prevention of influenza in household contacts can control spread of influenza in the community...
- Effects of inhaled steroids on growth, bone metabolism, and adrenal functionDavid B Allen
University of Wisconsin Children s Hospital, H4 448 CSC Pediatrics, 600 Highland Avenue, Madison, WI 53792, USA
Adv Pediatr 53:101-10. 2006For children who have persistent asthma of any degree, ICS treatment is recommended...
- Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and childrenFrancine M Ducharme
Research Centre, CHU Sainte Justine and the Department of Pediatrics, University of Montreal, 3175 Cote Sainte Catherine, Montreal, , Canada, H3T 1C5
Cochrane Database Syst Rev 5:CD005535. 2010..inhaled ss(2)-adrenergic agonists (LABAs) are recommended as 'add-on' medication to inhaled corticosteroids (ICS) in the maintenance therapy of asthmatic adults and children aged two years and above...
- KRN5500 induces apoptosis (PCD) of myeloid leukemia cell lines and patient blastsK C Stine
Department of Pediatrics, University of Arkansas for Medical Sciences at Arkansas Children s Hospital, 800 Marshall St, Little Rock, AR 72202, USA
Leuk Res 24:741-9. 2000..was to determine if KRN5500, a spicamycin derivative with a unique acyl tail, would induce programmed cell death (PCD) of myeloid leukemia cell lines and cryopreserved leukemic blasts from newly diagnosed children with acute leukemia ..
- Clinical effectiveness of inhaled corticosteroids versus montelukast in children with asthma: prescription patterns and patient adherence as key factorsFrancine M Ducharme
Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada
Curr Med Res Opin 28:111-9. 2012To examine the real-life effectiveness of inhaled corticosteroids (ICS) versus leukotriene receptor antagonists (LTRA) monotherapy in children with mild or moderate asthma.
- Long-acting β-agonists in asthma management: what is the current status?Satya Mysore
Department of Respiratory Medicine, The Queen Elizabeth Hospital, Woodville, SA, Australia
Drugs 71:2091-7. 2011..compared with placebo in asthma patients using variable (from nil to regular) doses of inhaled corticosteroids (ICS) have raised the issue of mortality risk in patients with asthma taking regular LABA...
- The retina of the PCD/PCD mouse as a model of photoreceptor degeneration. A structural and functional studyMiguel Marchena
Department of Physiology, School of Medicine, University of Alcala, Alcala de Henares, Madrid, Spain
Exp Eye Res 93:607-17. 2011In this work, we used the pcd (Purkinje cell degeneration) mutant mouse with a slow temporal progression of photoreceptor degeneration in order to analyze the structural and functional modifications in the neuronal populations of the ..
- Mitochondrial proteome during salt stress-induced programmed cell death in riceXi Chen
Department of Biochemistry and Molecular Biology, Nanjing Agricultural University, Weigang, China
Plant Physiol Biochem 47:407-15. 2009It has been shown that mitochondria play a pivotal role in plant programmed cell death (PCD). Previous study established a salt stress-induced PCD model in rice (Oryza sativa L. cv...
- Economic impact of using inhaled corticosteroids without prior exacerbation among elderly patients with chronic obstructive pulmonary disorderS Chen
United BioSource Corporation, 430 Bedford Street, Lexington, MA 02420, USA
J Med Econ 14:458-62. 2011To assess the economic impact of initiating inhaled corticosteroids (ICS) without evidence of prior exacerbation among elderly patients with chronic obstructive pulmonary disease (COPD) in the US.
- RNA and DNA bacteriophages as molecular diagnosis controls in clinical virology: a comprehensive study of more than 45,000 routine PCR testsLaetitia Ninove
UMR190, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
PLoS ONE 6:e16142. 2011..of viral genomes in various human specimens and require for validation both external and internal controls (ECs and ICs)...
- Extra-Fine Inhaled Corticosteroid Effect on Distal Lung Disease in AsthmaMichelle Zeidler; Fiscal Year: 2007..Chlorofluorcarbon (CFC) inhaled corticosteroids (ICS), the mainstay of asthma treatment, cannot effectively reach the distal lung due to their relatively large particle ..
- Combination drug treatment to inhibit multiple cell death pathways after TBIALAN FADEN; Fiscal Year: 2009..The caspase-independent programmed cell death (PCD) is due in large part to the activation/translocation of apoptosis-inducing factor (AIF)...
- Analyses of neutrophil interaction with immune complexesTanya N Mayadas; Fiscal Year: 2011..lines of evidence that the low affinity activating neutrophil Fc(Rs in mice, which preferentially complex with IgG-ICs, directly mediate neutrophil accumulation...
- Obesity, Inflammation and Response to Therapy in AsthmaEVERETT SUTHERLAND; Fiscal Year: 2007..groups and 3) if biomarkers of GC insensitivity are predictive of attenuated response to inhaled corticosteroid (ICS) therapy...
- Obesity, Inflammation and Response to Therapy in AsthmaEVERETT RAND SUTHERLAND; Fiscal Year: 2010..groups and 3) if biomarkers of GC insensitivity are predictive of attenuated response to inhaled corticosteroid (ICS) therapy...
- Pediatric Asthma Alert Intervention in Minority ChildrenARLENE MANNS BUTZ; Fiscal Year: 2010..Inhaled corticosteroids (ICS) are the cornerstone of treatment for patients with persistent asthma and can prevent exacerbations and ED visits...
- Pediatric Asthma Alert Intervention in Minority ChildrenArlene Butz; Fiscal Year: 2009..Inhaled corticosteroids (ICS) are the cornerstone of treatment for patients with persistent asthma and can prevent exacerbations and ED visits...
- PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAKeoki Williams; Fiscal Year: 2009Inhaled corticosteroids (ICS) are considered first-line therapy for the management and control of patients with persistent asthma...
- PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAKeoki Williams; Fiscal Year: 2010Inhaled corticosteroids (ICS) are considered first-line therapy for the management and control of patients with persistent asthma...
- STRUCTURAL BIOLOGY OF DIOXYGENASESDouglas Ohlendorf; Fiscal Year: 2003..The principal target of this project has been protocatechuate 3,4-dioxygenase (3,4-PCD; Fe+3 cofactor, cleaves aromatic rings between hydroxyls) which has been used as a model system...
- Molecular Basis of Pathogen-Induced Cell Death in PlantsJEAN GREENBERG; Fiscal Year: 2009..approaches to examine a major signaling pathway that controls innate immunity and programmed cell death (PCD). The control of plant defenses has many parallels with human innate immunity...
- Molecular Basis of Pathogen-Induced Cell Death in PlantsJEAN GREENBERG; Fiscal Year: 2007..approaches to examine a major signaling pathway that controls innate immunity and programmed cell death (PCD). The control of plant defenses has many parallels with human innate immunity...
- Molecular Basis of Pathogen-Induced Cell Death in PlantsJEAN GREENBERG; Fiscal Year: 2007..approaches to examine a major signaling pathway that controls innate immunity and programmed cell death (PCD). The control of plant defenses has many parallels with human innate immunity...
- Analyses of neutrophil interaction with immune complexesTanya N Mayadas; Fiscal Year: 2010..lines of evidence that the low affinity activating neutrophil Fc(Rs in mice, which preferentially complex with IgG-ICs, directly mediate neutrophil accumulation...
- IDENTIFICATION OF BIOCHEMICAL ABNORMALITIES IN PCD CILIALAWRENCE OSTROWSKI; Fiscal Year: 2002Primary ciliary dyskinesia (PCD) is an inherited disease which is characterized by various ultrastructural abnormalities in the cilia lining the respiratory tract...
- MOLECULAR ANALYSIS OF FLAGELLAR DYNEIN FUNCTIONStephen King; Fiscal Year: 1999..The heavy chains contain the motor activity of the complex. The ICs are related to each other and to the ICs of cytoplasmic dynein...
- Mechanisms of Kinase-dependent Regulation of the V-ATPase in KidneyNuria Pastor Soler; Fiscal Year: 2009..Individuals with defective V-ATPase activity in kidney intercalated cells (ICs) may suffer from severe chronic metabolic acidosis with potential severe sequelae in bone, kidney, and other organs...
- Mechanisms of Kinase-dependent Regulation of the V-ATPase in KidneyNURIA M PASTOR SOLER; Fiscal Year: 2010..Individuals with defective V-ATPase activity in kidney intercalated cells (ICs) may suffer from severe chronic metabolic acidosis with potential severe sequelae in bone, kidney, and other organs...
- Conditional Deletion of Dnaic1 as a Model of Primary Ciliary DyskinesiaLAWRENCE OSTROWSKI; Fiscal Year: 2007..Recent work has identified mutations in two ciliary proteins, DNAI1 and DNAH5, which together account for the disease in about 20% of the patients analyzed...
- BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULEGeorge Schwartz; Fiscal Year: 2007..The novel protein hensin is expressed in the extracellular matrix (ECM) surrounding adapting B-intercalated cells (ICs). Aim 1 examines how Cyclosporin A (CsA) causes a distal renal tubular acidosis by preventing adaptation of B-ICs...
- BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULEGeorge J Schwartz; Fiscal Year: 2010..The novel protein hensin is expressed in the extracellular matrix (ECM) surrounding adapting B-intercalated cells (ICs). Aim 1examines how Cyclosporin A (CsA) causes a distal renal tubular acidosis by preventing adaptation of B-ICs...
- ANALYSES OF LEUKOCYTE INTERACTIONS WITH IMMUNE COMPLEXESTanya Mayadas; Fiscal Year: 2003..Under static conditions, neutrophil adhesion to ICs is supported by the low affinity Fcgamma receptors (FcgammaR) II and III, and Mac-1 (CD11b/CD18, CR3), a member of ..
- Apoptosis Execution Pathways in Dopaminergic Cell DeathJun Chen; Fiscal Year: 2007..the etiology remains unknown, there is considerable evidence that supports the view that programmed cell death (PCD) contributes, at least in part, to the degeneration of dopaminergic neurons in PD...