Gene Symbol: DNAI1
Description: dynein, axonemal, intermediate chain 1
Alias: CILD1, DIC1, ICS1, PCD, dynein, axonemal, intermediate polypeptide 1, immotile cilia syndrome 1
Species: human

Top Publications

  1. ncbi EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive
    T E Milner
    Departement de Physiologie, Universite de Montreal, Quebec, Canada
    J Neurophysiol 73:2568-77. 1995
  2. pmc Assessment of erythrocyte shape by flow cytometry techniques
    M Piagnerelli
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    J Clin Pathol 60:549-54. 2007
  3. pmc Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation
    Maimoona A Zariwala
    University of North Carolina at Chapel Hill 27599 7248, USA, and Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Germany
    Am J Respir Crit Care Med 174:858-66. 2006
  4. pmc Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome)
    C Guichard
    Laboratoire de Génétique Moléculaire Humaine, Equipe d Accueil 3088, Université C Bernard Lyon 1, 69373 Lyon Cedex 8, France
    Am J Hum Genet 68:1030-5. 2001
  5. ncbi Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia
    M Zariwala
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Am J Respir Cell Mol Biol 25:577-83. 2001
  6. pmc Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia
    G Pennarun
    Institut National de la Santé et de la Recherche Médicale U468, Hopital Henri Mondor, 94010 Creteil, France
    Am J Hum Genet 65:1508-19. 1999
  7. doi DNAI1 mutations explain only 2% of primary ciliary dykinesia
    Mike Failly
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Respiration 76:198-204. 2008
  8. pmc Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells
    M Shimizu
    Department of Psychiatry and Neuroscience, Kure National Hospital, Japan
    Br J Pharmacol 114:1282-8. 1995
  9. pmc Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor
    J K Ward
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 111:1095-102. 1994
  10. doi Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis
    Diana M Sobieraj
    University of Connecticut School of Pharmacy, Storrs, Connecticut, USA
    Clin Ther 30:1416-25. 2008

Detail Information

Publications212 found, 100 shown here

  1. ncbi EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive
    T E Milner
    Departement de Physiologie, Universite de Montreal, Quebec, Canada
    J Neurophysiol 73:2568-77. 1995
    ..wild-type) mice (+/+), as well as five lurcher (lc/+), six nervous (nr/nr), and eight Purkinje cell degeneration (pcd/pcd) mutants were implanted with chronic electromyogram (EMG) electrodes in the hamstring and quadriceps muscle ..
  2. pmc Assessment of erythrocyte shape by flow cytometry techniques
    M Piagnerelli
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    J Clin Pathol 60:549-54. 2007
    ..Several techniques are available to assess alterations in RBC rheology, especially deformability, but they are too cumbersome to be used on a large number of cells...
  3. pmc Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation
    Maimoona A Zariwala
    University of North Carolina at Chapel Hill 27599 7248, USA, and Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Germany
    Am J Respir Crit Care Med 174:858-66. 2006
    ..Disease-causing mutations have been reported in DNAI1 and DNAH5 encoding outer dynein arm (ODA) proteins of cilia.
  4. pmc Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome)
    C Guichard
    Laboratoire de Génétique Moléculaire Humaine, Equipe d Accueil 3088, Université C Bernard Lyon 1, 69373 Lyon Cedex 8, France
    Am J Hum Genet 68:1030-5. 2001
    ..The axonemal dynein intermediate-chain gene 1 (DNAI1), which has been demonstrated to be responsible for a case of primary ciliary dyskinesia (PCD) without situs ..
  5. ncbi Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia
    M Zariwala
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Am J Respir Cell Mol Biol 25:577-83. 2001
    ..Mutations in an intermediate chain dynein (DNAI1; IC78) have recently been described in PCD patients, with outer dynein arm (ODA) defects...
  6. pmc Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia
    G Pennarun
    Institut National de la Santé et de la Recherche Médicale U468, Hopital Henri Mondor, 94010 Creteil, France
    Am J Hum Genet 65:1508-19. 1999
    ..advantage of the evolutionary conservation of genes encoding axonemal proteins, we have isolated a human sequence (DNAI1) related to IC78, a C...
  7. doi DNAI1 mutations explain only 2% of primary ciliary dykinesia
    Mike Failly
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Respiration 76:198-204. 2008
    ..To date, 5 genes encoding 3 dynein protein arm subunits (DNAI1, DNAH5 and DNAH11), the kinase TXNDC3 and the X-linked RPGR have been found to be mutated in PCD.
  8. pmc Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells
    M Shimizu
    Department of Psychiatry and Neuroscience, Kure National Hospital, Japan
    Br J Pharmacol 114:1282-8. 1995
    ..It is unlikely that this enhancement of cyclic AMP accumulation is caused by long-term antagonism of the 5-HT receptor by amitriptyline...
  9. pmc Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor
    J K Ward
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 111:1095-102. 1994
    ..These data suggest that an atypical 5-HT receptor inhibits the release of neuropeptides from sensory C fibres and may act as other inhibitory neuromodulators via the opening of a common K'channel...
  10. doi Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis
    Diana M Sobieraj
    University of Connecticut School of Pharmacy, Storrs, Connecticut, USA
    Clin Ther 30:1416-25. 2008
  11. pmc Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atrium
    A D Medhurst
    SmithKline Beecham Pharmaceuticals, The Pinnacles, Harlow, Essex
    Br J Pharmacol 110:1023-30. 1993
    ..6. The sinoatrial 5-HT4 receptor in the piglet has a pharmacological profile that correlates well with 5-HT4 receptors characterized in rat oesophagus, guinea-pig ileum and colon, mouse embryonic colliculi neurones and human atrium...
  12. pmc Mediation by 5-HT1D receptors of 5-hydroxytryptamine-induced contractions of rabbit middle and posterior cerebral arteries
    V Deckert
    Laboratoires Fournier, Daix, France
    Br J Pharmacol 112:939-45. 1994
    ..7. In conclusion, these results suggest that the contractile response to 5-HT in rabbit isolated MCA and PCA is predominantly mediated by the 5-HTID receptor subtype, although a small contribution by 5-HT3 receptors cannot be excluded...
  13. ncbi Microtubular discontinuities as acquired ciliary defects in airway epithelium of patients with chronic respiratory diseases
    J L Carson
    Department of Pediatrics and Cell Biology and Anatomy, University of North Carolina at Chapel Hill
    Ultrastruct Pathol 18:327-32. 1994
    ..cilia characterized by microtubular discontinuities and previously associated with primary ciliary dyskinesia (PCD) has been documented in other forms of chronic airways diseases, including cystic fibrosis (CF)...
  14. ncbi [Primary ciliary dyskinesia in situs inversus without bronchiectasis]
    J Gierich
    , Fachkliniken Wangen,
    Pneumologie 51:1127-32. 1997
    ..In adults suffering from Kartagener's syndrome-which is found in 50% of patients with primary ciliary dyskinesia (PCD)-bronchiectasis is still one of three typical clinical features...
  15. ncbi In-situ end labelling with bromodeoxyuridine--an advanced technique for the visualization of apoptotic cells in histological specimens
    A Aschoff
    , , Germany
    Horm Metab Res 28:311-4. 1996
    The fragmentation of nuclear DNA is considered to be a biochemical indication of programmed cell death (PCD) in various tissues...
  16. pmc Characterization of 5-HT3 receptors of N1E-115 neuroblastoma cells by use of the influx of the organic cation [14C]-guanidinium
    H Bonisch
    Institut fur Pharmakologie und Toxikologie, Universitat Bonn, Germany
    Br J Pharmacol 108:436-42. 1993
    ..7. It is concluded that [14C]-guanidinium influx measurement in N1E-115 cells is a convenient method to study properties of the cation channel of the 5-HT3 receptor. This influx is independent of the fast sodium channel...
  17. ncbi Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance
    D Promeneur
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 279:F1014-26. 2000
    ..Overall, these results suggest that AQP6 expression in collecting duct ICs is regulated by altered acid/alkali load or water balance. Thus AQP6 may contribute to maintenance of acid-base homeostasis and water balance...
  18. pmc Characterization of 5-hydroxytryptamine receptors mediating mucosal secretion in guinea-pig ileum
    P J Johnson
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 111:1240-4. 1994
  19. ncbi An anatomical classification--a new paradigm for management of urinary dysfunction in the female
    P E Papa Petros
    Royal Perth Hospital, Western Australia
    Int Urogynecol J Pelvic Floor Dysfunct 10:29-35. 1999
  20. ncbi Correlations between ciliary structure and ciliary function
    T Willems
    ENT Department, UZ GHB, Leuven, Belgium
    Acta Otorhinolaryngol Belg 54:299-308. 2000
    ..COR), coordinated ciliary activity and ciliary immotility were investigated based on the findings in over 700 non-PCD biopsies taken in the context of diagnostic investigations for respiratory problems...
  21. ncbi Evaluation of the utilization patterns of leukotriene modifiers in a large managed care health plan
    Paul G Lakomski
    Excellus Health Plan, Inc, 344 South Warren St, Syracuse, NY 13202, USA
    J Manag Care Pharm 10:115-21. 2004
  22. ncbi Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in children under the age of 12 years
    C Main
    Peninsula Technology Assessment Group PenTAG, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, UK
    Health Technol Assess 12:1-174, iii-iv. 2008
    ..To assess the clinical and cost-effectiveness of inhaled corticosteroids (ICS) alone and ICS used in combination with a long-acting beta2 agonist (LABA) in the treatment of chronic asthma in children aged under 12 years...
  23. pmc 5-Hydroxytryptamine (5-HT) mediates potent relaxation in the sheep isolated pulmonary vein via activation of 5-HT4 receptors
    T M Cocks
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Br J Pharmacol 107:591-6. 1992
    ..This preparation may thus provide a robust and sensitive bioassay for future development of selective 5-HT4 receptor agonists and antagonists...
  24. pmc Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells
    Linda Mathsson
    Unit of Clinical Immunology, Uppsala University, Uppsala, Sweden
    Arthritis Res Ther 8:R64. 2006
    ..Suppression of monocytes/macrophages in RA joints or blockade of the primate-specific activating FcgammaRIIa receptor might be ways to reduce IC-induced TNF-alpha production in the joints of seropositive RA patients...
  25. pmc Programmed death in bacteria
    K Lewis
    Biotechnology Center, Tufts University, Medford, Massachusetts 02155, USA
    Microbiol Mol Biol Rev 64:503-14. 2000
    Programmed cell death (PCD) in bacteria plays an important role in developmental processes, such as lysis of the mother cell during sporulation of Bacillus subtilis and lysis of vegetative cells in fruiting body formation of Myxococcus ..
  26. ncbi Regulation of ion and water transport across the eel intestine: effects of acetylcholine and serotonin
    Y Mori
    Faculty of Integrated Arts and Sciences, Hiroshima University, Japan
    J Comp Physiol B 161:387-92. 1991
    ..Since atropine and ICS-205930 block ACh and 5-HT receptors, respectively, these results suggest that endogenous ACh and 5-HT are released by EFS...
  27. pmc Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma
    Francine M Ducharme
    Research Centre, CHU Sainte Justine and the Department of Pediatrics, University of Montreal, 3175 Cote Sainte Catherine, Montreal, , Canada, H3T 1C5
    Cochrane Database Syst Rev 4:CD005533. 2010
    ..These trends raised concern about the safety of combination therapy in view of modest improvement in children under the age of 12 years...
  28. doi Cost-effectiveness of budesonide/formoterol for maintenance and reliever asthma therapy in Denmark--cost-effectiveness analysis based on five randomised controlled trials
    Jannie Wickstrøm
    MUUSMANN COWI, Kolding, Denmark
    Clin Respir J 3:169-80. 2009
  29. ncbi Prevention of nausea and vomiting in cisplatin-treated patients by a selective 5-hydroxytryptamine (5-HT3) receptor antagonist, ICS 205-930
    L Dogliotti
    Department of Clinical and Biological Sciences, University of Torino, Italy
    Tumori 76:595-8. 1990
    ..2%) in 2 patients. These results suggest that ICS 205-930 is an effective and well tolerated antiemetic drug in patients receiving cisplatin chemotherapy...
  30. ncbi A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma
    Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, France
    Clin Ther 24:1-20. 2002
    ..Although inhaled corticosteroids (ICS) are commonly used in the treatment of persistent asthma, the relationship between dose and clinical response remains unclear...
  31. doi 111In-labeled immunoconjugates (ICs) bispecific for the epidermal growth factor receptor (EGFR) and cyclin-dependent kinase inhibitor, p27Kip1
    Bart Cornelissen
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    Cancer Biother Radiopharm 24:163-73. 2009
  32. pmc Inhibition of translation initiation on Escherichia coli gnd mRNA by formation of a long-range secondary structure involving the ribosome binding site and the internal complementary sequence
    J T Chang
    Department of Biological Sciences, University of Maryland Baltimore County 21228, USA
    J Bacteriol 177:6560-7. 1995
  33. ncbi Diverse effects of Purkinje cell loss on deep cerebellar and vestibular nuclei neurons in Purkinje cell degeneration mutant mice: a possible compensatory mechanism
    J Bäurle
    Department of Physiology, Freie Universitat Berlin, Fachbereich Humanmedizin, Universitatsklinikum Benjamin Franklin, Germany
    J Comp Neurol 384:580-96. 1997
    The genetic defect in the Purkinje cell degeneration (PCD) mutant mouse completely disrupts the cerebellar corticonuclear connection through intrinsic action on the final integrating unit of the cerebellar cortex, the Purkinje cell (PC)...
  34. pmc Blockade of 5-HT3 receptor-mediated currents in dissociated frog sensory neurones by benzoxazine derivative, Y-25130
    T Yakushiji
    Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd, Japan
    Br J Pharmacol 107:853-7. 1992
    ..6. Y-25130 (5 x 10-10 M) caused a rightward shift of the concentration-response curve for 5-HT while decreasing the maximum response.7. The results suggest that Y-25130 is a potent antagonist of the 5-HT3 receptor-channel complex...
  35. pmc An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes
    P H Driggers
    Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:3743-7. 1990
    ..The presence of multiple factors that bind common IFN response motifs may partly account for the complexity and diversity of IFN action as well as IFN-regulated gene expression...
  36. ncbi Effects of 5-HT(3) receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats
    Z A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol 21:73-85. 2000
  37. ncbi Inhibiting effects of serotonin and serotonin antagonists on the migration of mononuclear leucocytes
    L Bondesson
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 15:243-50. 1993
    ..No inhibiting effects of serotonin or the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both serotonin and serotonin antagonists may inhibit mononuclear leucocyte migration...
  38. ncbi Necrosis is an active and controlled form of programmed cell death
    S Ya Proskuryakov
    Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249020, Russia
    Biochemistry (Mosc) 67:387-408. 2002
    In all studies on programmed cell death (PCD) and apoptosis as its most showy form, this process was considered to be a paradigmatic antithesis to necrotic cell death...
  39. ncbi Regular use of corticosteroids and low use of short-acting beta2-agonists can reduce asthma hospitalization
    Ambikaipakan Senthilselvan
    Department of Public Health Sciences, University of Alberta, 13 106B Clinical Sciences Building, Edmonton, AL, Canada, T6G 2G3
    Chest 127:1242-51. 2005
    ..The objective of this study was to determine the effect of ICS use on the association between use of ISABA and first hospitalization for asthma after controlling for several indicators of asthma severity...
  40. ncbi Sites of action of mu-, kappa- and sigma-opiate receptor agonists at the feline ileocecal sphincter
    A Ouyang
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104
    Am J Physiol 254:G224-31. 1988
    ..mu-Receptor activation causes ICS contraction via a cholinergic pathway...
  41. ncbi Removal of As(III) in a column reactor packed with iron-coated sand and manganese-coated sand
    Yoon Young Chang
    Department of Environmental Engineering, Kwangwoon University, Seoul 139 701, Republic of Korea
    J Hazard Mater 150:565-72. 2008
    ..From this work, a filtration system consisting of both MCS and ICS can potentially be used a new treatment system to simultaneously treat As(III) and As(V)...
  42. ncbi Is there a role for inhaled corticosteroids and macrolide therapy in bronchiectasis?
    Paul King
    Monash University, Department of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia
    Drugs 67:965-74. 2007
    ..The evidence available suggests that both medications have a role in the management of bronchiectasis. More definitive trials of ICS and macrolides in bronchiectasis will clarify the likely benefit of these therapies...
  43. ncbi Safety of inhaled budesonide: clinical manifestations of systemic corticosteroid-related adverse effects
    Camilla Christensson
    Patient Safety, Clinical Development, AstraZeneca R and D Lund, Lund, Sweden
    Drug Saf 31:965-88. 2008
  44. ncbi Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia
    J Neesen
    Institute of Human Genetics, University of Gottingen, Germany
    Cytogenet Genome Res 98:38-44. 2002
    Primary ciliary dyskinesia (PCD) is a heterogeneous autosomal recessive disease that is caused by impaired ciliary and flagellar functions. About 50% of PCD patients show situs inversus, denoted as Kartagener syndrome...
  45. ncbi Administrative claims analysis of asthma-related health care utilization for patients who received inhaled corticosteroids with either montelukast or salmeterol as combination therapy
    Felicia C Allen-Ramey
    Merck and Co, Sumneytown Pike, WP39 170, West Point, PA 19486 0004, USA
    J Manag Care Pharm 12:310-21. 2006
  46. ncbi Deregulated sequential motion of centromeres induced by antitumor agents may lead to genome instability in human peripheral blood lymphocytes
    V Bajic
    Institute for Biomedical Research, Galenika a d, Belgrade, Serbia
    J BUON 12:77-83. 2007
    ..Alteration of the sequence of centromere separation or premature centromere division (PCD) has been found to be significantly higher in populations exposed to various xenobiotics...
  47. pmc Alternative splicing and gene duplication differentially shaped the regulation of isochorismate synthase in Populus and Arabidopsis
    Yinan Yuan
    School of Forest Resources and Environmental Science, Michigan Technological University, Houghton, MI 49931, USA
    Proc Natl Acad Sci U S A 106:22020-5. 2009
    ..AtICS1 represents a divergent isoform for inducible SA synthesis during defense. Populus ICS primarily functions in phylloquinone biosynthesis, a process that can be sustained at low ICS transcript levels...
  48. doi Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indianapolis, USA
    Alcohol 44:245-55. 2010
    ..In addition, chronic operant ethanol self-administration and/or repeated treatments with a 5-HT(3) receptor antagonist may alter neuronal circuitry within the posterior VTA...
  49. pmc Chloroplast and reactive oxygen species involvement in apoptotic-like programmed cell death in Arabidopsis suspension cultures
    Siamsa M Doyle
    School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
    J Exp Bot 61:473-82. 2010
    ..ROS are known to act as regulators of programmed cell death (PCD) in plant and animal cells, so it is possible that chloroplasts have a role in regulating PCD in green tissue...
  50. doi Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future
    Kian Fan Chung
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    Eur J Clin Pharmacol 65:853-71. 2009
    ..Other agents that could improve the efficacy of corticosteroids or reverse corticosteroid insensitivity may be added to ICS. ICS in combination with LABAs will continue to remain the main focus of treatment of airways diseases...
  51. ncbi ICS 205-930 reduces 5-methoxytryptamine-induced short-circuit current in stripped pig jejunum
    M B Hansen
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Can J Physiol Pharmacol 72:227-32. 1994
    ..These data suggest involvement of a neuronal 5-HT4 receptor subtype and acetylcholine in 5-HT elicited SCC and chloride secretion in the pig jejunum...
  52. ncbi Impact of inhaled corticosteroid-induced oropharyngeal adverse events: results from a meta-analysis
    Gary S Rachelefsky
    Allergy Research Foundation Inc, UCLA School of Medicine, Los Angeles, California 90025, USA
    Ann Allergy Asthma Immunol 98:225-38. 2007
    ..Oropharyngeal adverse events associated with inhaled corticosteroid (ICS) use can affect adherence; however, these effects have been studied less extensively than those that occur systemically...
  53. ncbi Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study
    C Strazielle
    Centre de Recherche en Sciences Neurologiques, Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Neuroscience 94:287-304. 1999
    The mouse "Purkinje cell degeneration" (pcd) is characterized by a primary loss of Purkinje cells, as well as by retrograde and secondary partial degeneration of cerebellar granule cells and inferior olivary neurons; this neurological ..
  54. ncbi Benefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids
    D C Grootendorst
    Dutch Asthma Centre, Davos, Switzerland
    Clin Exp Allergy 31:400-8. 2001
    ..These findings indicate that short-term, rigorous allergen avoidance can improve the long-term control of severe asthma over and above what can be achieved even by high doses of inhaled steroids...
  55. doi Inhaled corticosteroids in children: use and effects of early treatment on asthma and lung function. Prevalence of asthma and the impact of severity in early life on later asthma in childhood
    Chandra Sekhar Devulapalli
    Department of Paediatrics, Ringerike Hospital, Hønefoss, Norway
    Clin Respir J 2:247-8. 2008
    ..The role of inhaled corticosteroids (ICS) on disease progression in asthmatic children is not yet clear...
  56. ncbi Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands
    T W de Vries
    Department of Pediatrics, Medical Centre Leeuwarden, P O Box 888, 8901 BR Leeuwarden, The Netherlands
    Eur J Clin Pharmacol 62:343-6. 2006
    ..Inhaled corticosteroids (ICS) are widely used in the treatment of asthma. We studied the suspected adverse drug reactions (sADRs) reported during the use of ICS in the Netherlands...
  57. doi Association between previous health care use and initiation of inhaled corticosteroid and long-acting beta2-adrenergic agonist combination therapy among US patients with asthma
    Christopher M Blanchette
    Division of Clinical and Outcomes Research, Lovelace Respiratory Research Institute, Kannapolis, North Carolina 287081, USA
    Clin Ther 31:2574-83. 2009
  58. ncbi Inter-crystal scatter in a dual layer, high resolution LSO-APD positron emission tomograph
    M Rafecas
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22 81675 München, Germany
    Phys Med Biol 48:821-48. 2003
  59. ncbi Soluble LDL-immune complexes in type 2 diabetes and vascular disease
    Z Turk
    Vuk Vrhovac University Clinic for Diabetes, Dugi dol 4a, 10000 Zagreb
    Horm Metab Res 34:196-201. 2002
    ..The objective of our study was to analyse markers of LDL oxidation-soluble LDL containing immune complexes (LDL-ICs) in type 2 diabetes with micro- and macrovascular disease...
  60. ncbi A comparison of the risk of hospitalizations due to chronicobstructive pulmonary disease in medicaid patients with various medication regimens, including ipratropium, inhaled corticosteroids, salmeterol, or their combination
    Karen L Rascati
    College of Pharmacy, University of Texas at Austin, Austin, Texas 78712 0127, USA
    Clin Ther 27:346-54. 2005
    ..The aim of this study was to compare the risk of hospitalizations related to chronic obstructive pulmonary disease (COPD) among Medicaid patients prescribed various medication regimens...
  61. ncbi Effects on resource utilization of adding salmeterol in combination or separately to inhaled corticosteroids
    James Chan
    Pharmacy Outcomes Research Group, Kaiser Permanente Medical Care Program, 1800 Harrison, 13th Fl, Oakland, CA 94612, USA
    J Manag Care Pharm 13:21-7. 2007
  62. doi Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
    M Bradley Drummond
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    JAMA 300:2407-16. 2008
    ..Recent studies of inhaled corticosteroid (ICS) therapy for managing stable chronic obstructive pulmonary disease (COPD) have yielded conflicting results regarding survival and risk of adverse events...
  63. ncbi Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas
    W Li
    Department of Ophthalmology, Allegheny University, Philadelphia, PA 19102, USA
    Cell Mol Biol (Noisy-le-grand) 45:59-66. 1999
    Because programmed cell death (PCD) is an important mode of pericyte dropout in human diabetic retinopathy, whether increased oxidative stress in cells with diminished antioxidant defenses plays a causative role in the PCD process in ..
  64. ncbi [Immunocontraceptive effect of DNA vaccines of Lagurus lagurus zona pellucida 3 fusioned with C-terminal of HSP70]
    Yu Zhang
    Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:354-7. 2008
    ..To investigate the immunocontraceptive effect of Lagurus lagurus zona pellucida 3 gene (LZP3) fused by Mycobacterium tuberculosis HSP70 and C-terminal of HSP70...
  65. ncbi Sonographically guided percutaneous catheter drainage versus needle aspiration in the management of pyogenic liver abscess
    Enver Zerem
    Interventional Ultrasonography Department, University Clinical Center, Trnovac bb, Tuzla, Bosnia and Herzegovina
    AJR Am J Roentgenol 189:W138-42. 2007
    The purpose of this study was to determine the effectiveness of percutaneous catheter drainage (PCD) and to compare PCD with percutaneous needle aspiration in the management of liver abscess.
  66. ncbi Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma
    R Buhl
    Pulmonary Department, Mainz University Hospital, Mainz, Germany
    Curr Med Res Opin 23:1867-78. 2007
    ..This option is well tolerated and offers greater reductions in asthma exacerbations together with similar improvements in daily symptom control, at a lower overall steroid load, compared with fixed-dose ICS/LABA plus SABA...
  67. ncbi Patterns and determinants of compliance with inhaled steroids in adults with asthma
    Yves Lacasse
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Ste Foy, Qubec, Canada
    Can Respir J 12:211-7. 2005
    ..Patient compliance with inhaled corticosteroids (ICS) in asthma is considered to be suboptimal...
  68. doi [Primary ciliary dyskinesia (Pcd) in Austria]
    Irena Lesic
    Medizinische Universität Wien, Universitätsklinik für Kinder und Jugendheilkunde, Wien, Austria
    Wien Klin Wochenschr 121:616-22. 2009
    Primary ciliary dyskinesia (PCD) is a rare hereditary recessive disease with symptoms of recurrent pneumonia, chronic bronchitis, bronchiectasis, and chronic sinusitis...
  69. pmc Living with primary ciliary dyskinesia: a prospective qualitative study of knowledge sharing, symptom concealment, embarrassment, mistrust, and stigma
    Simon Whalley
    Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK
    BMC Pulm Med 6:25. 2006
    Primary ciliary dyskinesia (PCD) is a chronic respiratory disease for which there is little psycho-social research and no qualitative studies of individuals living with the condition...
  70. ncbi Von Willebrand factor, fibrinogen and other risk factors of thrombosis in patients with a history of cerebrovascular ischemic stroke and their children
    M Jastrzebska
    Clinical Biochemistry and Laboratory Diagnostics, Regional Center for Atherosclerosis Research, Pomeranian Academy of Medicine, Al Powstaców Wlkp 72, PL 70 111 Szczecin, Poland
    Nutr Metab Cardiovasc Dis 12:132-40. 2002
    ..We investigated whether the vWF and Fb levels in patients with ischemic cerebrovascular stroke (ICS) correlate with those in their children...
  71. ncbi Apoptosis: correlation of cytological changes with biochemical markers in hormone-dependent tissues
    A Aschoff
    Department of Anatomy II, Friedrich-Schiller-University, Jena, Germany
    Horm Metab Res 29:535-43. 1997
    The term apoptosis, also known as programmed cell death (PCD), is used in contrast to necrotic cell death and occurs in various tissues in many different circumstances...
  72. doi Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling
    Wen Wen
    Corresponding Authors Hong Yang Wang, International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital Institute, Second Military Medical University, 225 Changhai Road, 200438 Shanghai, China
    Mol Cancer Ther 12:1796-804. 2013
    ..These results suggest that cyclin G1-induced liver T-IC expansion contributes to the recurrence and chemoresistance of hepatoma, and cyclin G1 may be a promising biomarker for individualized therapy of hepatocellular carcinoma patients...
  73. pmc A comparative study of three ternary complexes prepared in different mixing orders of siRNA/redox-responsive hyperbranched poly (amido amine)/hyaluronic acid
    Cheng Jun Chen
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing, People s Republic of China
    Int J Nanomedicine 7:3837-49. 2012
    In this study, a novel redox-responsive hyperbranched poly(amido amine) (named PCD) was synthesized and used as a cationic polymer to form a ternary complex with small interfering RNA (siRNA) and hyaluronic acid (HA) for siRNA delivery...
  74. ncbi Group I metabotropic receptors down-regulate nitric oxide induced caspase-3 activity in rat hippocampal neurons
    K Maiese
    Department of Neurology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurosci Lett 264:17-20. 1999
    ..NO) have been shown to require a host of signal transduction pathways to modulate neuronal programmed cell death (PCD)...
  75. ncbi [The treatment of asthma: indications for a change in approach]
    P N R Dekhuijzen
    Universitair Medisch Centrum St Radboud, afd Longziekten, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 150:237-41. 2006
  76. ncbi Plant autophagy puts the brakes on cell death by controlling salicylic acid signaling
    Kohki Yoshimoto
    Plant Immunity Research Team, RIKEN Plant Science Center, Tsurumi ku, Yokohama, Japan
    Autophagy 6:192-3. 2010
    ..autophagy defects in higher plants result in early senescence and excessive immunity-related programmed cell death (PCD), irrespective of nutrient conditions...
  77. doi Thirteen-year follow-up of early intervention with an inhaled corticosteroid in patients with asthma
    Tari Haahtela
    Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland
    J Allergy Clin Immunol 124:1180-5. 2009
    ..During the third year of the study, terbutaline-treated patients received budesonide (delayed therapy). Differences in lung function and bronchial responsiveness to histamine were observed between the 2 groups...
  78. ncbi Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax
    Woong Sun
    Department of Neurobiology and Anatomy and Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 24:11205-13. 2004
    ..subset of these survive and differentiate into mature neurons, whereas the majority undergo programmed cell death (PCD)...
  79. ncbi Preparation and characterization of polypseudorotaxanes based on block-selected inclusion complexation between poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) triblock copolymers and alpha-cyclodextrin
    Jun Li
    Institute of Materials Research and Engineering IMRE, 3 Research Link, Singapore 117602, Republic of Singapore
    J Am Chem Soc 125:1788-95. 2003
    ..The findings reported in this article suggested interesting possibilities in designing other cyclodextrin ICs and polypseudorotaxanes with block structures...
  80. doi Triamcinolone and ritonavir leading to drug-induced Cushing syndrome and adrenal suppression: description of a new case and review of the literature
    C Schwarze-Zander
    Department of Internal Medicine I, University Hospital Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Infection 41:1183-7. 2013
  81. doi Dehydroascorbate: a possible surveillance molecule of oxidative stress and programmed cell death in the green alga Chlamydomonas reinhardtii
    Omer Murik
    Department of Plant and Environmental Sciences, The Hebrew University of Jerusalem, Edmond J Safra Campus, Givat Ram, Jerusalem, 91904, Israel
    New Phytol 202:471-84. 2014
    ..If H2 O2 is provided 1.5-9 h after an initial dose, it induces programmed cell death (PCD) in the wild-type, but not in the dum1 mutant impaired in the mitochondrial respiratory complex III...
  82. doi Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults
    Bhupendrasinh F Chauhan
    Clinical Research Unit on Childhood Asthma, Research Centre, CHU Sainte Justine, Montreal, Canada
    Cochrane Database Syst Rev 2:CD009611. 2013
    ..However, often, ICS are used intermittently by patients or recommended by physicians to be used only at the onset of exacerbations...
  83. pmc Variation in DNAH1 may contribute to primary ciliary dyskinesia
    Faiqa Imtiaz
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh, 11211, Saudi Arabia
    BMC Med Genet 16:14. 2015
    Primary Ciliary Dyskinesia (PCD) is a genetically heterogeneous ciliopathy caused by ultrastructural defects in ciliary or flagellar structure and is characterized by a number of clinical symptoms including recurrent respiratory ..
  84. pmc A cluster-randomized trial to provide clinicians inhaled corticosteroid adherence information for their patients with asthma
    L Keoki Williams
    Center for Health Services Research, Henry Ford Health System, Detroit, MI 48202, USA
    J Allergy Clin Immunol 126:225-31, 231.e1-4. 2010
    ..Inhaled corticosteroid (ICS) nonadherence is common among patients with asthma; however, interventions to improve adherence have often been complex and not easily applied to large patient populations...
  85. doi Apoptosis in yeast: triggers, pathways, subroutines
    D Carmona-Gutierrez
    Institute of Molecular Biosciences, Karl Franzens University, Graz, Austria
    Cell Death Differ 17:763-73. 2010
    ..cerevisiae) can undergo apoptosis uncovered the possibility to investigate this mode of programmed cell death (PCD) in a model organism that combines both technical advantages and a eukaryotic 'cell room...
  86. doi Evaluation of adrenocortical function in 3-7 aged asthmatic children treated with moderate doses of fluticasone propionate: reliability of dehydroepiandrosterone sulphate (dhea-s) as a screening test
    U M Sahiner
    Department of Pediatric Allergy, Dr Sami Ulus Children s Hospital, 06080 Ankara, Turkey
    Allergol Immunopathol (Madr) 39:154-8. 2011
    ..Dehydroepiandrosterone sulphate (DHEA-S) is a corticotropin-dependent adrenal androgen precursor that is supressible in patients treated with ICS...
  87. doi Polygonatum cyrtonema lectin, a potential antineoplastic drug targeting programmed cell death pathways
    Shu Ya Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Biochem Biophys Res Commun 406:497-500. 2011
    ..for cancer biologists because PCL bears remarkable anti-tumor activities and thus inducing programmed cell death (PCD) including apoptosis and autophagy in cancer cells...
  88. doi Effect of different asthma treatments on risk of cold-related exacerbations
    H K Reddel
    Woolcock Institute of Medical Research, Australia
    Eur Respir J 38:584-93. 2011
    ..Subanalyses suggested the importance of the ICS component in reducing cold-related exacerbations. Future studies should document the cause of exacerbations, in order to allow identification of different treatment effects...
  89. doi Effects of an Integrated Care System on quality of care and satisfaction for children with special health care needs
    Caprice Knapp
    Department of Health Outcomes and Policy, University of Florida, 1329 SW 16th Street, Room 5130, Gainesville, FL 32610, USA
    Matern Child Health J 16:579-86. 2012
    ..It is important to present these interim findings so that progress can be monitored and decision-makers can begin to consider if the program should be expanded statewide...
  90. doi Plant programmed cell death caused by an autoactive form of Prf is suppressed by co-expression of the Prf LRR domain
    Xinran Du
    Department of Plant, Soil and Entomological Sciences, University of Idaho, Moscow, ID 83844, USA
    Mol Plant 5:1058-67. 2012
    ..interactions and activates signaling leading to host defense responses including localized programmed cell death (PCD) that is associated with the arrest of Pst growth...
  91. pmc Stimulus-related independent component and voxel-wise analysis of human brain activity during free viewing of a feature film
    Juha M Lahnakoski
    Brain and Mind Laboratory, Department of Biomedical Engineering and Computational Science, School of Science, Aalto University, Espoo, Finland
    PLoS ONE 7:e35215. 2012
    ..Our results encourage the use of naturalistic stimuli and tasks in cognitive neuroimaging to study how the brain processes stimuli in rich natural environments...
  92. pmc Quantifying axon diameter and intra-cellular volume fraction in excised mouse spinal cord with q-space imaging
    Henry H Ong
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neuroimage 51:1360-6. 2010
    ..92, p<0.05) with measurements from histology (0.68+/-0.07). These methods may provide insight into axonal architecture in normal and abnormal WM tissue but additional validation with more samples will be needed...
  93. pmc Characterization of Myxococcus xanthus MazF and implications for a new point of regulation
    Tye O Boynton
    Department of Microbiology, University of Georgia, Athens, GA 30602, USA
    Mol Microbiol 87:1267-76. 2013
    During development, Myxococcus xanthus cells undergo programmed cell death (PCD) whereby 80% of vegetative cells die. Previously, the MazF RNA interferase has been implicated in this role...
  94. pmc Analysis of transcriptional profiles and functional clustering of global cerebellar gene expression in PCD3J mice
    Gregory D Ford
    Department of Neurobiology and Neurotoxicology, Meharry Medical College, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 377:556-61. 2008
    The Purkinje cell degeneration (PCD) mutant mouse is characterized by a degeneration of cerebellar Purkinje cells and progressive ataxia...
  95. ncbi Purkinje cell degeneration elevates eupneic and hypercapnic ventilation in rats
    Fadi Xu
    Department of Pathophysiology, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Cerebellum 3:133-40. 2004
    ..The awake normal and PCD rats were separately placed in an unrestrained whole-body plethysmograph and ventilatory parameters measured before ..
  96. ncbi The fibronectin-derived anti-adhesive peptide III14-2 suppresses adhesion and apoptosis of leukemic cell lines through down-regulation of protein-tyrosine phosphorylation
    F Fukai
    Department of Patho physiology, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan
    Cell Mol Biol (Noisy-le-grand) 46:145-52. 2000
    ..that the FN peptide containing this anti-adhesive site, termed peptide III14-2, affects programmed cell death (PCD) (apoptosis) as well as cell adhesion by down-regulating protein-tyrosine phosphorylation...
  97. ncbi [The role of leukotriene D4 antagonist in allergic rhinitis with steroid resistance]
    Shenhong Qu
    The Otorhinolaryngeal Hospital of the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, 510080, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 19:557-9. 2005
    ..To study the effect of using leukotriene D4 antagonist (LTRAs) and inhaled corticosteroid (ICS) to allergic rhinitis (AR), as well as the effect of leukotriene D4 antagonist on allergic rhinitis with steroid resistance...
  98. ncbi In vivo and in vitro evidence for autocrine DCoH/HNF-1alpha transcription of albumin in the human epidermis
    S Hasse
    Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Exp Dermatol 14:182-7. 2005
    ..double immunofluorescence labelling, we identified that albumin colocalized together with its transcription factor PCD/DCoH/HNF-1alpha in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in ..
  99. ncbi Speech and language findings associated with paraneoplastic cerebellar degeneration
    Teresa Paslawski
    Department of Educational Psychology and Special Education, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Am J Speech Lang Pathol 14:200-7. 2005
    Paraneoplastic cerebellar degeneration (PCD) is an autoimmune disease that can be associated with cancer of the breast, lung, and ovary. The clinical presentation of PCD commonly includes ataxia, visual disturbances, and dysarthria...
  100. pmc Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons
    R Meller
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
    Epilepsy Res 70:3-14. 2006
    In response to harmful stresses, cells induce programmed cell death (PCD) or apoptosis. Seizures can induce neural damage and activate biochemical pathways associated with PCD...
  101. ncbi BAL eotaxin and IL-5 in asthma, and the effects of inhaled corticosteroid and beta2 agonist
    Bryce N Feltis
    Respiratory Research Group, Tasmanian School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
    Respirology 9:507-13. 2004
    ..It is hypothesised that changes in airway eosinophils would be related to eosinophil cytokines...

Research Grants72

  1. Extra-Fine Inhaled Corticosteroid Effect on Distal Lung Disease in Asthma
    Michelle Zeidler; Fiscal Year: 2007
    ..This study will determine the potential to modify distal airways inflammation which may ultimately improve asthma control. [unreadable] [unreadable]..
    Keoki Williams; Fiscal Year: 2013
    ..Knowledge gained from this study may help clinicians select asthma treatments most likely to work for their patients, as well as provide insight for future asthma therapeutics. ..
  3. Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia
    Lawrence E Ostrowski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary ciliary dyskinesia (PCD) is an autosomal recessive disease caused by mutations that disrupt ciliary function and result in defective mucociliary clearance (MCC)...
  4. Inhaled Fluticasone Effects on Upper Airway Patency in Obstructive Lung Disease
    Mihaela Teodorescu; Fiscal Year: 2013
    ..abstract_text> ..
  5. Genetics of lung function and asthma severity in African Americans
    Deborah A Meyers; Fiscal Year: 2013
  6. Washington University AsthmaNet
    Mario Castro; Fiscal Year: 2013
    ..In summary, these studies address current gaps in the evidence base for asthma treatment decision making as well as explore novel therapeutic strategies in patients in whom inadequate asthma control remains commonplace. ..
  7. Noninvasive imaging of eosinophils
    Angelique Y Louie; Fiscal Year: 2013
    ..The ability to image the cells in vivo can aid in design of therapy as well as in monitoring the effectiveness of therapy. ..
  8. A Patient Advocate and Literacy-Based Treatment of Asthma
    Andrea J Apter; Fiscal Year: 2010
    ..It is compared for efficacy and cost-effectiveness with asthma education. We fulfill ARRA goals by creating or retaining partial or complete funding for 16 area jobs. ..
  9. PESBART: Effects of Physical Environment and Stress in Blacks in Relation to Asth
    Elliot Israel; Fiscal Year: 2013
  10. CAMP Continuation Study/Phase 3
    Hartmut Grasemann; Fiscal Year: 2010
    ..End of Abstract.) ..
  11. CAMP Continuation Study/Phase 3
    Robert Strunk; Fiscal Year: 2010
    ..End of Abstract.) ..
  12. Smoking in Asthmatics Pilot Study
    JOE WESLEY RAMSDELL; Fiscal Year: 2013
  13. Clinical Centers for the NHLBI Asthma Network (AsthmaNet)
    Stanley J Szefler; Fiscal Year: 2013
    ..The National Jewish site will contribute collaborative experience, leadership skills and commitment for recruitment of adults and children to participate in AsthmaNet trials. ..
  14. Uncontrolled Lower Respiratory Symptoms in the WTC Survivor Program
    Joan Reibman; Fiscal Year: 2013
  15. Causal Inference of Disease-Relevant Regulatory Networks
    Jen hwa Chu; Fiscal Year: 2013
    ..We believe the proposed method will give more insight to the underlying biology of differential drug response and lead to development of more effective treatment plan for patients. ..
  16. An Asthma Adherence Telehealth System to Improve Asthma Management
    ANDREW GEORGE WEINSTEIN; Fiscal Year: 2013
    ..We will market to disease management companies and entities with financial risk such as ACOs, patient-centered medical homes, at-risk provider networks, insurers and the VA. ..
  17. Inhaled Mometasone to Promote Reduction in Vaso-occlusive Events (IMPROVE)
    JEFFREY AVINS GLASSBERG; Fiscal Year: 2013
  18. Real-world patient responsiveness &safety of long-acting beta agonists in asthma
    Pingsheng Wu; Fiscal Year: 2013
    ..Such knowledge will have widespread public health impact in asthma disease management. ..
  19. Modulation of Asthma by GSNO-based Therapies
    Loretta G Que; Fiscal Year: 2013
    ..Completion of these specific aims will critically advance our understanding of the potential impact and limitations of GSNO- based therapies as acute and chronic treatments for asthma. ! ..
  20. BELT: Blacks &Exacerbations on LABA vs. Tiotropium
    Elliot Israel; Fiscal Year: 2011
  21. AsthmaNet: Phenotypic Influences on Asthma Treatments
    Sally E Wenzel; Fiscal Year: 2013
    ..Finally, the severe asthma protocol will focus on the mast cell, specifically prostaglandin D2 and its interaction with CRTH2. We believe these studies address unmet needs in asthma and will improve its therapy. ..
  22. AsthmaNet: Brigham and Women's Hospital &Children's Hospital Boston
    Wanda Phipatanakul; Fiscal Year: 2013
  23. The resident cell in the asthmatic airway
    Daniel J Tschumperlin; Fiscal Year: 2013
    ..abstract_text> ..
  24. Adolescent Controlled Text Messaging to Improve Asthma Medication Adherence in Pr
    Maria T Britto; Fiscal Year: 2013
    ..Through this research, we will gather data on feasibility, usability and efficacy of the intervention that will ead to a future R01 application to examine the intervention's efficacy in a fully powered randomized trial. ..
    Craig P Hersh; Fiscal Year: 2013
    ..The clinical, imaging, and genetic predictors of ICS response will be combined to construct a predictive model, making an important step towards a personalized genomics approach to COPD symptom management. ..
  26. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
    ..We will estimate the incremental cost-effectiveness of PS. ..
  27. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010
    ..End of Abstract) ..
  28. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
  29. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ..The caspase-independent programmed cell death (PCD) is due in large part to the activation/translocation of apoptosis-inducing factor (AIF)...
  30. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2012
    ..The ultimate goal of this research project is to develop and evaluate in patients an innovative gene therapy approach that has the potential to treat and correct SCA. ..
  31. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2013
    ..It is hoped that the results of this study will allow safer application of this curative therapy to a greater number of patients and aid in improving tolerogenic therapy for autoimmunity and solid organ transplantation as well. ..
  32. Mechanistic study of the host defense functions of IL-32 in tuberculosis
    Edward D Chan; Fiscal Year: 2013
    ..reduces viability of intracellular MTB by inducing macrophages to undergo various types of programmed cell death (PCD), including caspase-3-dependent and caspase-independent apoptosis as well as pyroptosis, a unique form of ..
  33. Progesterone &Estrogen Differentially Regulate DC Function in Lupus Autoimmunity
    Grant Hughes; Fiscal Year: 2012
    ..Moreover, they will identify novel therapeutic approaches for treatment and prevention of disease development in SLE patients. ..
  34. Pilot Studies of Gene Therapy for Primary Ciliary Dyskinesia
    Lawrence E Ostrowski; Fiscal Year: 2010
    ..application is focused on developing gene therapy as a treatment for the rare disease Primary Ciliary Dyskinesia (PCD)...
  35. Programmed Cell Death and Disease Resistance in Arabidopsis
    Roger W Innes; Fiscal Year: 2013
    ..provided by applicant): This project focuses on the molecular mechanisms that mediate programmed cell death (PCD) in plants, specifically in response to pathogen infection...
  36. Genetic Disorder of Mucocilary Clearance
    Michael R Knowles; Fiscal Year: 2013
    ..the past 4 years, this Consortium has made great progress in studies of variant CF, Primary Ciliary Dyskinesia (PCD), and pseudohypoaldosteronism...
    Albert R La Spada; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Purkinje cell degeneration (pcd) mouse is a recessive model of neurodegeneration, involving the retina and cerebellum, with a phenotype of ataxia and blindness...
  38. Analyses of neutrophil interaction with immune complexes
    Tanya N Mayadas; Fiscal Year: 2013
    ..abstract_text> ..
  39. Identification and Characterization of New Genes Required for Cilia Motility
    Jennifer R Panizzi; Fiscal Year: 2010
    ..goal of this proposed research is to further elucidate the mechanisms underlying primary ciliary dyskinesia (PCD)...
  40. Potassium Homeostasis in the Inner Ear
    Ebenezer N Yamoah; Fiscal Year: 2013
    ..abstract_text> ..
    Edward S Mocarski; Fiscal Year: 2013
    ..Programmed cell death (PCD), sensor-triggered interferon activation, and signaling cascades are all affected starting at early times during ..
  42. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..Project Description Page 6 ..
  43. Innate Immune Activation in Malaria
    Douglas T Golenbock; Fiscal Year: 2013
    ..Gallego spends in South America will increase, with the ultimate goal of exporting cutting edge technology and expertise to the scientific community in Colombia. ..
  44. Neuroprotection in Models of Cerebral Ischemia
    Jun Chen; Fiscal Year: 2013
    ..Our results support the current concept that mitochondrial-dependent programmed cell death (PCD) and necrosis-triggered neuroinflammation via microglial overactivation are two important mechanisms that ..
  45. Role of Inflammation in Progressive Multifocal Leukoencephalopathy
    Igor J Koralnik; Fiscal Year: 2012
    ..The knowledge we will gain from these studies will greatly expand our understanding of JCV pathogenesis and will have a direct impact on patient care. ..
    N Louise Glass; Fiscal Year: 2013
    ..Nonself recognition leads to a type of fungal programmed cell death (PCD) termed heterokaryon incompatibility (HI)...
  47. Mechanisms of Kinase-dependent Regulation of the V-ATPase in Kidney
    NURIA M PASTOR-SOLER; Fiscal Year: 2013
    ..The successful completion of the Aims of this application will contribute to new strategies to treat disorders of acidification in the kidney and in the urogenital tract. ..
  48. Physician Attitudes toward New Biomedical HIV Prevention Interventions in Youth
    Tanya L Kowalczyk Mullins; Fiscal Year: 2013
  49. The molecular mechanisms by which mammalian Fused regulates motile cilia function
    Pao Tien Chuang; Fiscal Year: 2012
    ..Dysfunction of motile cilia and flagella underlies the human syndrome of primary ciliary dyskinesia (PCD)...
  50. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2013
    ..Relevance: The results will shed light on the pathogenesis of IgAN and identify therapeutic targets for disease-specific treatment of IgAN as well as potential response/prognostic biomarkers. ..
  51. Application of Omics in Lung Disease
    Claire M Doerschuk; Fiscal Year: 2013
    ..Microbiomics pursues the airway microbiome in COPD, CF, PCD, environmental lung disease and pneumonia...
  52. Dynamic regulation of salicylic acid biosynthesis &perception in plant immunity
    Xinnian Dong; Fiscal Year: 2013
    ..broad-spectrum resistance that can be induced by a local pathogen challenge that results in programmed cell death (PCD) or by exogenous application of SA. SA signaling requires the function of the transcription cofactor NPR1 protein...
    George J Schwartz; Fiscal Year: 2013
    ..The results of these studies are likely to change our understanding of acid-base physiology and elicit new mechanisms for heretofore unexplained causes of distal renal tubular acidosis. ..
  54. Microparticles as a Source of Nuclear Antigens in Systemic Lupus Erythematosus
    David Stephen Pisetsky; Fiscal Year: 2010
    ..Understanding the role of microparticles in the immune complex disease will provide information to allow the development of new treatments as well as markers to assess the course of SLE and its renal and vascular complications. ..
  55. Regulation of proton pump trafficking in kidney
    Dennis Brown; Fiscal Year: 2013
    ..abstract_text> ..
  56. Mechanisms of Associative Learning in Aging: Mouse Models
    Diana S Woodruff Pak; Fiscal Year: 2010
    ..explores neuron and glia number and learning in young homozygous and aging heterozygous Purkinje cell degeneration (pcd) mutant mice. Aims 3 and 4 examine functional aging of neurons in hippocampal and cerebellar slices, respectively...
  57. ??PK mediated melanoma stem cell oncolysis through non-redundant programmed cell
    ARIC G COLUNGA; Fiscal Year: 2011
    ..efforts seek to improve replication but virotherapy strategies based on the induction of programmed cell death (PCD) are not available...
  58. Citrullinated Antigens Bridge Innate and Adaptive Immunity in RA
    Jeremy Sokolove; Fiscal Year: 2013
    Douglas Ohlendorf; Fiscal Year: 2003
    ..The principal target of this project has been protocatechuate 3,4-dioxygenase (3,4-PCD; Fe+3 cofactor, cleaves aromatic rings between hydroxyls) which has been used as a model system...
  60. Molecular Basis of Pathogen-Induced Cell Death in Plants
    JEAN GREENBERG; Fiscal Year: 2009
    ..approaches to examine a major signaling pathway that controls innate immunity and programmed cell death (PCD). The control of plant defenses has many parallels with human innate immunity...
    James Russell; Fiscal Year: 2001
    ..studies, we find that hyperglycemia leads to impaired rat DRG sensory neuronal growth and programmed cell death (PCD). In both paradigms, IGF-I is neuroprotective...
    Laurence Corash; Fiscal Year: 1993
    ..A photochemical decontamination(PCD) technique has been developed utilizing 8-methoxypsoralen (8-MOP) and long wavelength ultraviolet irradiation (UVA) ..
    LAWRENCE OSTROWSKI; Fiscal Year: 2002
    Primary ciliary dyskinesia (PCD) is an inherited disease which is characterized by various ultrastructural abnormalities in the cilia lining the respiratory tract...
  64. Conditional Deletion of Dnaic1 as a Model of Primary Ciliary Dyskinesia
    LAWRENCE OSTROWSKI; Fiscal Year: 2007
    ..Recent work has identified mutations in two ciliary proteins, DNAI1 and DNAH5, which together account for the disease in about 20% of the patients analyzed...
  65. Apoptosis Execution Pathways in Dopaminergic Cell Death
    Jun Chen; Fiscal Year: 2007
    ..the etiology remains unknown, there is considerable evidence that supports the view that programmed cell death (PCD) contributes, at least in part, to the degeneration of dopaminergic neurons in PD...