DNAI1

Summary

Gene Symbol: DNAI1
Description: dynein, axonemal, intermediate chain 1
Alias: CILD1, DIC1, ICS1, PCD, dynein intermediate chain 1, axonemal, dynein, axonemal, intermediate polypeptide 1, immotile cilia syndrome 1
Species: human

Top Publications

  1. ncbi EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive
    T E Milner
    Departement de Physiologie, Universite de Montreal, Quebec, Canada
    J Neurophysiol 73:2568-77. 1995
  2. pmc Assessment of erythrocyte shape by flow cytometry techniques
    M Piagnerelli
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    J Clin Pathol 60:549-54. 2007
  3. pmc Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome)
    C Guichard
    Laboratoire de Génétique Moléculaire Humaine, Equipe d Accueil 3088, Université C Bernard Lyon 1, 69373 Lyon Cedex 8, France
    Am J Hum Genet 68:1030-5. 2001
  4. pmc Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia
    G Pennarun
    Institut National de la Santé et de la Recherche Médicale U468, Hopital Henri Mondor, 94010 Creteil, France
    Am J Hum Genet 65:1508-19. 1999
  5. pmc Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation
    Maimoona A Zariwala
    University of North Carolina at Chapel Hill 27599 7248, USA, and Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Germany
    Am J Respir Crit Care Med 174:858-66. 2006
  6. doi DNAI1 mutations explain only 2% of primary ciliary dykinesia
    Mike Failly
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Respiration 76:198-204. 2008
  7. ncbi Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia
    M Zariwala
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Am J Respir Cell Mol Biol 25:577-83. 2001
  8. pmc Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells
    M Shimizu
    Department of Psychiatry and Neuroscience, Kure National Hospital, Japan
    Br J Pharmacol 114:1282-8. 1995
  9. pmc Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor
    J K Ward
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 111:1095-102. 1994
  10. doi Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis
    Diana M Sobieraj
    University of Connecticut School of Pharmacy, Storrs, Connecticut, USA
    Clin Ther 30:1416-25. 2008

Detail Information

Publications156 found, 100 shown here

  1. ncbi EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive
    T E Milner
    Departement de Physiologie, Universite de Montreal, Quebec, Canada
    J Neurophysiol 73:2568-77. 1995
    ..wild-type) mice (+/+), as well as five lurcher (lc/+), six nervous (nr/nr), and eight Purkinje cell degeneration (pcd/pcd) mutants were implanted with chronic electromyogram (EMG) electrodes in the hamstring and quadriceps muscle ..
  2. pmc Assessment of erythrocyte shape by flow cytometry techniques
    M Piagnerelli
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    J Clin Pathol 60:549-54. 2007
    ..Several techniques are available to assess alterations in RBC rheology, especially deformability, but they are too cumbersome to be used on a large number of cells...
  3. pmc Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome)
    C Guichard
    Laboratoire de Génétique Moléculaire Humaine, Equipe d Accueil 3088, Université C Bernard Lyon 1, 69373 Lyon Cedex 8, France
    Am J Hum Genet 68:1030-5. 2001
    ..The axonemal dynein intermediate-chain gene 1 (DNAI1), which has been demonstrated to be responsible for a case of primary ciliary dyskinesia (PCD) without situs ..
  4. pmc Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia
    G Pennarun
    Institut National de la Santé et de la Recherche Médicale U468, Hopital Henri Mondor, 94010 Creteil, France
    Am J Hum Genet 65:1508-19. 1999
    ..advantage of the evolutionary conservation of genes encoding axonemal proteins, we have isolated a human sequence (DNAI1) related to IC78, a C...
  5. pmc Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation
    Maimoona A Zariwala
    University of North Carolina at Chapel Hill 27599 7248, USA, and Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Germany
    Am J Respir Crit Care Med 174:858-66. 2006
    ..Disease-causing mutations have been reported in DNAI1 and DNAH5 encoding outer dynein arm (ODA) proteins of cilia.
  6. doi DNAI1 mutations explain only 2% of primary ciliary dykinesia
    Mike Failly
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Respiration 76:198-204. 2008
    ..To date, 5 genes encoding 3 dynein protein arm subunits (DNAI1, DNAH5 and DNAH11), the kinase TXNDC3 and the X-linked RPGR have been found to be mutated in PCD.
  7. ncbi Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia
    M Zariwala
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Am J Respir Cell Mol Biol 25:577-83. 2001
    ..Mutations in an intermediate chain dynein (DNAI1; IC78) have recently been described in PCD patients, with outer dynein arm (ODA) defects...
  8. pmc Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells
    M Shimizu
    Department of Psychiatry and Neuroscience, Kure National Hospital, Japan
    Br J Pharmacol 114:1282-8. 1995
    ..It is unlikely that this enhancement of cyclic AMP accumulation is caused by long-term antagonism of the 5-HT receptor by amitriptyline...
  9. pmc Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor
    J K Ward
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 111:1095-102. 1994
    ..These data suggest that an atypical 5-HT receptor inhibits the release of neuropeptides from sensory C fibres and may act as other inhibitory neuromodulators via the opening of a common K'channel...
  10. doi Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis
    Diana M Sobieraj
    University of Connecticut School of Pharmacy, Storrs, Connecticut, USA
    Clin Ther 30:1416-25. 2008
    ....
  11. pmc Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atrium
    A D Medhurst
    SmithKline Beecham Pharmaceuticals, The Pinnacles, Harlow, Essex
    Br J Pharmacol 110:1023-30. 1993
    ..6. The sinoatrial 5-HT4 receptor in the piglet has a pharmacological profile that correlates well with 5-HT4 receptors characterized in rat oesophagus, guinea-pig ileum and colon, mouse embryonic colliculi neurones and human atrium...
  12. pmc Mediation by 5-HT1D receptors of 5-hydroxytryptamine-induced contractions of rabbit middle and posterior cerebral arteries
    V Deckert
    Laboratoires Fournier, Daix, France
    Br J Pharmacol 112:939-45. 1994
    ..7. In conclusion, these results suggest that the contractile response to 5-HT in rabbit isolated MCA and PCA is predominantly mediated by the 5-HTID receptor subtype, although a small contribution by 5-HT3 receptors cannot be excluded...
  13. ncbi Microtubular discontinuities as acquired ciliary defects in airway epithelium of patients with chronic respiratory diseases
    J L Carson
    Department of Pediatrics and Cell Biology and Anatomy, University of North Carolina at Chapel Hill
    Ultrastruct Pathol 18:327-32. 1994
    ..cilia characterized by microtubular discontinuities and previously associated with primary ciliary dyskinesia (PCD) has been documented in other forms of chronic airways diseases, including cystic fibrosis (CF)...
  14. ncbi [Primary ciliary dyskinesia in situs inversus without bronchiectasis]
    J Gierich
    , Fachkliniken Wangen,
    Pneumologie 51:1127-32. 1997
    ..In adults suffering from Kartagener's syndrome-which is found in 50% of patients with primary ciliary dyskinesia (PCD)-bronchiectasis is still one of three typical clinical features...
  15. ncbi In-situ end labelling with bromodeoxyuridine--an advanced technique for the visualization of apoptotic cells in histological specimens
    A Aschoff
    , , Germany
    Horm Metab Res 28:311-4. 1996
    The fragmentation of nuclear DNA is considered to be a biochemical indication of programmed cell death (PCD) in various tissues...
  16. pmc Characterization of 5-HT3 receptors of N1E-115 neuroblastoma cells by use of the influx of the organic cation [14C]-guanidinium
    H Bonisch
    Institut fur Pharmakologie und Toxikologie, Universitat Bonn, Germany
    Br J Pharmacol 108:436-42. 1993
    ..7. It is concluded that [14C]-guanidinium influx measurement in N1E-115 cells is a convenient method to study properties of the cation channel of the 5-HT3 receptor. This influx is independent of the fast sodium channel...
  17. ncbi Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance
    D Promeneur
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 279:F1014-26. 2000
    ..Overall, these results suggest that AQP6 expression in collecting duct ICs is regulated by altered acid/alkali load or water balance. Thus AQP6 may contribute to maintenance of acid-base homeostasis and water balance...
  18. pmc Characterization of 5-hydroxytryptamine receptors mediating mucosal secretion in guinea-pig ileum
    P J Johnson
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 111:1240-4. 1994
    ....
  19. ncbi An anatomical classification--a new paradigm for management of urinary dysfunction in the female
    P E Papa Petros
    Royal Perth Hospital, Western Australia
    Int Urogynecol J Pelvic Floor Dysfunct 10:29-35. 1999
    ....
  20. ncbi Correlations between ciliary structure and ciliary function
    T Willems
    ENT Department, UZ GHB, Leuven, Belgium
    Acta Otorhinolaryngol Belg 54:299-308. 2000
    ..COR), coordinated ciliary activity and ciliary immotility were investigated based on the findings in over 700 non-PCD biopsies taken in the context of diagnostic investigations for respiratory problems...
  21. ncbi Evaluation of the utilization patterns of leukotriene modifiers in a large managed care health plan
    Paul G Lakomski
    Excellus Health Plan, Inc, 344 South Warren St, Syracuse, NY 13202, USA
    J Manag Care Pharm 10:115-21. 2004
    ....
  22. ncbi Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in children under the age of 12 years
    C Main
    Peninsula Technology Assessment Group PenTAG, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, UK
    Health Technol Assess 12:1-174, iii-iv. 2008
    ..To assess the clinical and cost-effectiveness of inhaled corticosteroids (ICS) alone and ICS used in combination with a long-acting beta2 agonist (LABA) in the treatment of chronic asthma in children aged under 12 years...
  23. pmc 5-Hydroxytryptamine (5-HT) mediates potent relaxation in the sheep isolated pulmonary vein via activation of 5-HT4 receptors
    T M Cocks
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Br J Pharmacol 107:591-6. 1992
    ..This preparation may thus provide a robust and sensitive bioassay for future development of selective 5-HT4 receptor agonists and antagonists...
  24. pmc Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells
    Linda Mathsson
    Unit of Clinical Immunology, Uppsala University, Uppsala, Sweden
    Arthritis Res Ther 8:R64. 2006
    ..Suppression of monocytes/macrophages in RA joints or blockade of the primate-specific activating FcgammaRIIa receptor might be ways to reduce IC-induced TNF-alpha production in the joints of seropositive RA patients...
  25. pmc Programmed death in bacteria
    K Lewis
    Biotechnology Center, Tufts University, Medford, Massachusetts 02155, USA
    Microbiol Mol Biol Rev 64:503-14. 2000
    Programmed cell death (PCD) in bacteria plays an important role in developmental processes, such as lysis of the mother cell during sporulation of Bacillus subtilis and lysis of vegetative cells in fruiting body formation of Myxococcus ..
  26. ncbi Regulation of ion and water transport across the eel intestine: effects of acetylcholine and serotonin
    Y Mori
    Faculty of Integrated Arts and Sciences, Hiroshima University, Japan
    J Comp Physiol B 161:387-92. 1991
    ..Since atropine and ICS-205930 block ACh and 5-HT receptors, respectively, these results suggest that endogenous ACh and 5-HT are released by EFS...
  27. ncbi Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma
    Francine M Ducharme
    Research Centre, CHU Sainte Justine and the Department of Pediatrics, University of Montreal, 3175 Cote Sainte Catherine, Montreal, , Canada, H3T 1C5
    Cochrane Database Syst Rev 4:CD005533. 2010
    ..These trends raised concern about the safety of combination therapy in view of modest improvement in children under the age of 12 years...
  28. doi Cost-effectiveness of budesonide/formoterol for maintenance and reliever asthma therapy in Denmark--cost-effectiveness analysis based on five randomised controlled trials
    Jannie Wickstrøm
    MUUSMANN COWI, Kolding, Denmark
    Clin Respir J 3:169-80. 2009
    ....
  29. ncbi Prevention of nausea and vomiting in cisplatin-treated patients by a selective 5-hydroxytryptamine (5-HT3) receptor antagonist, ICS 205-930
    L Dogliotti
    Department of Clinical and Biological Sciences, University of Torino, Italy
    Tumori 76:595-8. 1990
    ..2%) in 2 patients. These results suggest that ICS 205-930 is an effective and well tolerated antiemetic drug in patients receiving cisplatin chemotherapy...
  30. ncbi A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma
    Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, France
    Clin Ther 24:1-20. 2002
    ..Although inhaled corticosteroids (ICS) are commonly used in the treatment of persistent asthma, the relationship between dose and clinical response remains unclear...
  31. pmc Inhibition of translation initiation on Escherichia coli gnd mRNA by formation of a long-range secondary structure involving the ribosome binding site and the internal complementary sequence
    J T Chang
    Department of Biological Sciences, University of Maryland Baltimore County 21228, USA
    J Bacteriol 177:6560-7. 1995
    ....
  32. doi 111In-labeled immunoconjugates (ICs) bispecific for the epidermal growth factor receptor (EGFR) and cyclin-dependent kinase inhibitor, p27Kip1
    Bart Cornelissen
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    Cancer Biother Radiopharm 24:163-73. 2009
    ....
  33. ncbi Diverse effects of Purkinje cell loss on deep cerebellar and vestibular nuclei neurons in Purkinje cell degeneration mutant mice: a possible compensatory mechanism
    J Bäurle
    Department of Physiology, Freie Universitat Berlin, Fachbereich Humanmedizin, Universitatsklinikum Benjamin Franklin, Germany
    J Comp Neurol 384:580-96. 1997
    The genetic defect in the Purkinje cell degeneration (PCD) mutant mouse completely disrupts the cerebellar corticonuclear connection through intrinsic action on the final integrating unit of the cerebellar cortex, the Purkinje cell (PC)...
  34. pmc Blockade of 5-HT3 receptor-mediated currents in dissociated frog sensory neurones by benzoxazine derivative, Y-25130
    T Yakushiji
    Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd, Japan
    Br J Pharmacol 107:853-7. 1992
    ..6. Y-25130 (5 x 10-10 M) caused a rightward shift of the concentration-response curve for 5-HT while decreasing the maximum response.7. The results suggest that Y-25130 is a potent antagonist of the 5-HT3 receptor-channel complex...
  35. pmc An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes
    P H Driggers
    Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:3743-7. 1990
    ..The presence of multiple factors that bind common IFN response motifs may partly account for the complexity and diversity of IFN action as well as IFN-regulated gene expression...
  36. ncbi Effects of 5-HT(3) receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats
    Z A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol 21:73-85. 2000
    ....
  37. ncbi Inhibiting effects of serotonin and serotonin antagonists on the migration of mononuclear leucocytes
    L Bondesson
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 15:243-50. 1993
    ..No inhibiting effects of serotonin or the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both serotonin and serotonin antagonists may inhibit mononuclear leucocyte migration...
  38. ncbi Necrosis is an active and controlled form of programmed cell death
    S Ya Proskuryakov
    Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249020, Russia
    Biochemistry (Mosc) 67:387-408. 2002
    In all studies on programmed cell death (PCD) and apoptosis as its most showy form, this process was considered to be a paradigmatic antithesis to necrotic cell death...
  39. ncbi Regular use of corticosteroids and low use of short-acting beta2-agonists can reduce asthma hospitalization
    Ambikaipakan Senthilselvan
    Department of Public Health Sciences, University of Alberta, 13 106B Clinical Sciences Building, Edmonton, AL, Canada, T6G 2G3
    Chest 127:1242-51. 2005
    ..The objective of this study was to determine the effect of ICS use on the association between use of ISABA and first hospitalization for asthma after controlling for several indicators of asthma severity...
  40. ncbi Removal of As(III) in a column reactor packed with iron-coated sand and manganese-coated sand
    Yoon Young Chang
    Department of Environmental Engineering, Kwangwoon University, Seoul 139 701, Republic of Korea
    J Hazard Mater 150:565-72. 2008
    ..From this work, a filtration system consisting of both MCS and ICS can potentially be used a new treatment system to simultaneously treat As(III) and As(V)...
  41. ncbi Is there a role for inhaled corticosteroids and macrolide therapy in bronchiectasis?
    Paul King
    Monash University, Department of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia
    Drugs 67:965-74. 2007
    ..The evidence available suggests that both medications have a role in the management of bronchiectasis. More definitive trials of ICS and macrolides in bronchiectasis will clarify the likely benefit of these therapies...
  42. ncbi Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia
    J Neesen
    Institute of Human Genetics, University of Gottingen, Germany
    Cytogenet Genome Res 98:38-44. 2002
    Primary ciliary dyskinesia (PCD) is a heterogeneous autosomal recessive disease that is caused by impaired ciliary and flagellar functions. About 50% of PCD patients show situs inversus, denoted as Kartagener syndrome...
  43. ncbi Safety of inhaled budesonide: clinical manifestations of systemic corticosteroid-related adverse effects
    Camilla Christensson
    Patient Safety, Clinical Development, AstraZeneca R and D Lund, Lund, Sweden
    Drug Saf 31:965-88. 2008
    ....
  44. ncbi Sites of action of mu-, kappa- and sigma-opiate receptor agonists at the feline ileocecal sphincter
    A Ouyang
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104
    Am J Physiol 254:G224-31. 1988
    ..mu-Receptor activation causes ICS contraction via a cholinergic pathway...
  45. pmc Alternative splicing and gene duplication differentially shaped the regulation of isochorismate synthase in Populus and Arabidopsis
    Yinan Yuan
    School of Forest Resources and Environmental Science, Michigan Technological University, Houghton, MI 49931, USA
    Proc Natl Acad Sci U S A 106:22020-5. 2009
    ..AtICS1 represents a divergent isoform for inducible SA synthesis during defense. Populus ICS primarily functions in phylloquinone biosynthesis, a process that can be sustained at low ICS transcript levels...
  46. ncbi Deregulated sequential motion of centromeres induced by antitumor agents may lead to genome instability in human peripheral blood lymphocytes
    V Bajic
    Institute for Biomedical Research, Galenika a d, Belgrade, Serbia
    J BUON 12:77-83. 2007
    ..Alteration of the sequence of centromere separation or premature centromere division (PCD) has been found to be significantly higher in populations exposed to various xenobiotics...
  47. ncbi Administrative claims analysis of asthma-related health care utilization for patients who received inhaled corticosteroids with either montelukast or salmeterol as combination therapy
    Felicia C Allen-Ramey
    Merck and Co, Sumneytown Pike, WP39 170, West Point, PA 19486 0004, USA
    J Manag Care Pharm 12:310-21. 2006
    ....
  48. ncbi ICS 205-930 reduces 5-methoxytryptamine-induced short-circuit current in stripped pig jejunum
    M B Hansen
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Can J Physiol Pharmacol 72:227-32. 1994
    ..These data suggest involvement of a neuronal 5-HT4 receptor subtype and acetylcholine in 5-HT elicited SCC and chloride secretion in the pig jejunum...
  49. ncbi The secondary nature of ciliary (dis)orientation in secondary and primary ciliary dyskinesia
    Mark Jorissen
    Department of ENT, Head and Neck Surgery, University Hospital Leuven, Leuven, Belgium
    Acta Otolaryngol 124:527-31. 2004
    ..secondary ciliary dyskinesia (SCD)] and in a very few cases as the single abnormality in primary ciliary dyskinesia (PCD). The etiology, pathogenesis, consequences and relevance of ciliary (dis)orientation are still unclear.
  50. pmc Chloroplast and reactive oxygen species involvement in apoptotic-like programmed cell death in Arabidopsis suspension cultures
    Siamsa M Doyle
    School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
    J Exp Bot 61:473-82. 2010
    ..ROS are known to act as regulators of programmed cell death (PCD) in plant and animal cells, so it is possible that chloroplasts have a role in regulating PCD in green tissue...
  51. doi Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indianapolis, USA
    Alcohol 44:245-55. 2010
    ..In addition, chronic operant ethanol self-administration and/or repeated treatments with a 5-HT(3) receptor antagonist may alter neuronal circuitry within the posterior VTA...
  52. doi Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future
    Kian Fan Chung
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    Eur J Clin Pharmacol 65:853-71. 2009
    ..Other agents that could improve the efficacy of corticosteroids or reverse corticosteroid insensitivity may be added to ICS. ICS in combination with LABAs will continue to remain the main focus of treatment of airways diseases...
  53. ncbi Impact of inhaled corticosteroid-induced oropharyngeal adverse events: results from a meta-analysis
    Gary S Rachelefsky
    Allergy Research Foundation Inc, UCLA School of Medicine, Los Angeles, California 90025, USA
    Ann Allergy Asthma Immunol 98:225-38. 2007
    ..Oropharyngeal adverse events associated with inhaled corticosteroid (ICS) use can affect adherence; however, these effects have been studied less extensively than those that occur systemically...
  54. ncbi Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study
    C Strazielle
    Centre de Recherche en Sciences Neurologiques, Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Neuroscience 94:287-304. 1999
    The mouse "Purkinje cell degeneration" (pcd) is characterized by a primary loss of Purkinje cells, as well as by retrograde and secondary partial degeneration of cerebellar granule cells and inferior olivary neurons; this neurological ..
  55. ncbi Benefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids
    D C Grootendorst
    Dutch Asthma Centre, Davos, Switzerland
    Clin Exp Allergy 31:400-8. 2001
    ..These findings indicate that short-term, rigorous allergen avoidance can improve the long-term control of severe asthma over and above what can be achieved even by high doses of inhaled steroids...
  56. doi Inhaled corticosteroids in children: use and effects of early treatment on asthma and lung function. Prevalence of asthma and the impact of severity in early life on later asthma in childhood
    Chandra Sekhar Devulapalli
    Department of Paediatrics, Ringerike Hospital, Hønefoss, Norway
    Clin Respir J 2:247-8. 2008
    ..The role of inhaled corticosteroids (ICS) on disease progression in asthmatic children is not yet clear...
  57. ncbi Inter-crystal scatter in a dual layer, high resolution LSO-APD positron emission tomograph
    M Rafecas
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22 81675 München, Germany
    Phys Med Biol 48:821-48. 2003
    ....
  58. ncbi Soluble LDL-immune complexes in type 2 diabetes and vascular disease
    Z Turk
    Vuk Vrhovac University Clinic for Diabetes, Dugi dol 4a, 10000 Zagreb
    Horm Metab Res 34:196-201. 2002
    ..The objective of our study was to analyse markers of LDL oxidation-soluble LDL containing immune complexes (LDL-ICs) in type 2 diabetes with micro- and macrovascular disease...
  59. doi Association between previous health care use and initiation of inhaled corticosteroid and long-acting beta2-adrenergic agonist combination therapy among US patients with asthma
    Christopher M Blanchette
    Division of Clinical and Outcomes Research, Lovelace Respiratory Research Institute, Kannapolis, North Carolina 287081, USA
    Clin Ther 31:2574-83. 2009
    ....
  60. ncbi Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands
    T W de Vries
    Department of Pediatrics, Medical Centre Leeuwarden, P O Box 888, 8901 BR Leeuwarden, The Netherlands
    Eur J Clin Pharmacol 62:343-6. 2006
    ..Inhaled corticosteroids (ICS) are widely used in the treatment of asthma. We studied the suspected adverse drug reactions (sADRs) reported during the use of ICS in the Netherlands...
  61. ncbi A comparison of the risk of hospitalizations due to chronicobstructive pulmonary disease in medicaid patients with various medication regimens, including ipratropium, inhaled corticosteroids, salmeterol, or their combination
    Karen L Rascati
    College of Pharmacy, University of Texas at Austin, Austin, Texas 78712 0127, USA
    Clin Ther 27:346-54. 2005
    ..The aim of this study was to compare the risk of hospitalizations related to chronic obstructive pulmonary disease (COPD) among Medicaid patients prescribed various medication regimens...
  62. ncbi Patterns and determinants of compliance with inhaled steroids in adults with asthma
    Yves Lacasse
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Ste Foy, Qubec, Canada
    Can Respir J 12:211-7. 2005
    ..Patient compliance with inhaled corticosteroids (ICS) in asthma is considered to be suboptimal...
  63. ncbi Effects on resource utilization of adding salmeterol in combination or separately to inhaled corticosteroids
    James Chan
    Pharmacy Outcomes Research Group, Kaiser Permanente Medical Care Program, 1800 Harrison, 13th Fl, Oakland, CA 94612, USA
    J Manag Care Pharm 13:21-7. 2007
    ....
  64. ncbi Sonographically guided percutaneous catheter drainage versus needle aspiration in the management of pyogenic liver abscess
    Enver Zerem
    Interventional Ultrasonography Department, University Clinical Center, Trnovac bb, Tuzla, Bosnia and Herzegovina
    AJR Am J Roentgenol 189:W138-42. 2007
    The purpose of this study was to determine the effectiveness of percutaneous catheter drainage (PCD) and to compare PCD with percutaneous needle aspiration in the management of liver abscess.
  65. doi [Primary ciliary dyskinesia (Pcd) in Austria]
    Irena Lesic
    Medizinische Universität Wien, Universitätsklinik für Kinder und Jugendheilkunde, Wien, Austria
    Wien Klin Wochenschr 121:616-22. 2009
    Primary ciliary dyskinesia (PCD) is a rare hereditary recessive disease with symptoms of recurrent pneumonia, chronic bronchitis, bronchiectasis, and chronic sinusitis...
  66. ncbi Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma
    R Buhl
    Pulmonary Department, Mainz University Hospital, Mainz, Germany
    Curr Med Res Opin 23:1867-78. 2007
    ..This option is well tolerated and offers greater reductions in asthma exacerbations together with similar improvements in daily symptom control, at a lower overall steroid load, compared with fixed-dose ICS/LABA plus SABA...
  67. ncbi Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas
    W Li
    Department of Ophthalmology, Allegheny University, Philadelphia, PA 19102, USA
    Cell Mol Biol (Noisy-le-grand) 45:59-66. 1999
    Because programmed cell death (PCD) is an important mode of pericyte dropout in human diabetic retinopathy, whether increased oxidative stress in cells with diminished antioxidant defenses plays a causative role in the PCD process in ..
  68. ncbi [Immunocontraceptive effect of DNA vaccines of Lagurus lagurus zona pellucida 3 fusioned with C-terminal of HSP70]
    Yu Zhang
    Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:354-7. 2008
    ..To investigate the immunocontraceptive effect of Lagurus lagurus zona pellucida 3 gene (LZP3) fused by Mycobacterium tuberculosis HSP70 and C-terminal of HSP70...
  69. pmc Living with primary ciliary dyskinesia: a prospective qualitative study of knowledge sharing, symptom concealment, embarrassment, mistrust, and stigma
    Simon Whalley
    Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK
    BMC Pulm Med 6:25. 2006
    Primary ciliary dyskinesia (PCD) is a chronic respiratory disease for which there is little psycho-social research and no qualitative studies of individuals living with the condition...
  70. doi Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
    M Bradley Drummond
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    JAMA 300:2407-16. 2008
    ..Recent studies of inhaled corticosteroid (ICS) therapy for managing stable chronic obstructive pulmonary disease (COPD) have yielded conflicting results regarding survival and risk of adverse events...
  71. ncbi Von Willebrand factor, fibrinogen and other risk factors of thrombosis in patients with a history of cerebrovascular ischemic stroke and their children
    M Jastrzebska
    Clinical Biochemistry and Laboratory Diagnostics, Regional Center for Atherosclerosis Research, Pomeranian Academy of Medicine, Al Powstaców Wlkp 72, PL 70 111 Szczecin, Poland
    Nutr Metab Cardiovasc Dis 12:132-40. 2002
    ..We investigated whether the vWF and Fb levels in patients with ischemic cerebrovascular stroke (ICS) correlate with those in their children...
  72. ncbi Apoptosis: correlation of cytological changes with biochemical markers in hormone-dependent tissues
    A Aschoff
    Department of Anatomy II, Friedrich-Schiller-University, Jena, Germany
    Horm Metab Res 29:535-43. 1997
    The term apoptosis, also known as programmed cell death (PCD), is used in contrast to necrotic cell death and occurs in various tissues in many different circumstances...
  73. ncbi Immune complexes alter cerebral microvessel permeability: roles of complement and leukocyte adhesion
    Karyn J Lister
    Department of Medicine and Monash Institute of Medical Research, Monash University, Victoria, Australia
    Am J Physiol Heart Circ Physiol 291:H694-704. 2006
    ..These findings demonstrate that ICs are capable of rapidly inducing inflammatory responses in the cerebral microvasculature, with the complement pathway and leukocyte recruitment playing critical roles in microvascular dysfunction...
  74. pmc Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis
    Denise N Bronner
    Department of Microbiology and Immunology, University of Michigan Medical School Ann Arbor, MI, USA
    Front Cell Infect Microbiol 3:83. 2013
    Programmed cell death (PCD) can play a crucial role in tuning the immune response to microbial infection. Although PCD can occur in different forms, all are mediated by a family of proteases called caspases...
  75. ncbi Isoflurane inhaled at the onset of reperfusion potentiates the cardioprotective effect of ischemic postconditioning through a NO-dependent mechanism
    Dominique Tessier-Vetzel
    INSERM U 660, Universite Paris XII, Creteil, France
    J Cardiovasc Pharmacol 47:487-92. 2006
    Postconditioning (PCD) is known to reduce infarct size (IS). Here, we investigated whether isoflurane, which is known to potentiate preconditioning, also potentiates PCD and whether NO is involved...
  76. ncbi Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients
    Setareh Shams'ili
    Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Brain 126:1409-18. 2003
    Paraneoplastic cerebellar degeneration (PCD) is a heterogeneous group of disorders characterized by subacute cerebellar ataxia, specific tumour types and (often) associated antineuronal antibodies...
  77. ncbi Inhaled corticosteroids are more effective in COPD patients when used with LABA than with SABA
    Victor A Kiri
    Worldwide Epidemiology GlaxoSmithKline R and D, Greenford, UK
    Respir Med 99:1115-24. 2005
    ..We conclude that in moderate to severe COPD patients, the combined use of ICS with LABA is more effective in reducing the risk of re-hospitalization or death than the combined use of ICS with SABA...
  78. ncbi Photocatalytic reactivities of Nafion-coated TiO2 for the degradation of charged organic compounds under UV or visible light
    Hyunwoong Park
    School of Environmental Science and Engineering and Department of Chemistry, Pohang University of Science and Technology, Pohang 790 794, Korea
    J Phys Chem B 109:11667-74. 2005
    ..groups)-coated TiO2 particles (Nf/TiO2) were prepared and their reactivities for the photocatalytic degradation (PCD) of charged organic substrates were investigated...
  79. doi Programmed cell death in C. elegans, mammals and plants
    Christina E N Lord
    Dalhousie University, Department of Biology, 1355 Oxford Street Halifax, Nova Scotia, B3H 4R2 Canada
    Eur J Cell Biol 91:603-13. 2012
    Programmed cell death (PCD) is the regulated removal of cells within an organism and plays a fundamental role in growth and development in nearly all eukaryotes. In animals, the model organism Caenorhabditis elegans (C...
  80. ncbi TGF-beta modulates programmed cell death in the retina of the developing chick embryo
    N Dunker
    University of Saarland, Department of Anatomy, D 66421 Homburg Saar, Germany
    Development 128:1933-42. 2001
    Programmed cell death (PCD) is a key phenomenon in the regulation of cell number in multicellular organisms...
  81. pmc Programmed cell death promotes male sterility in the functional dioecious Opuntia stenopetala (Cactaceae)
    Lluvia Flores-Rentería
    Laboratorio de Desarrollo en Plantas, Departamento de Biología Comparada, Facultad de Ciencias, UNAM Mexico, DF 04510 Mexico
    Ann Bot 112:789-800. 2013
    ..In this study, the cellular changes that lead to male sterility in the functionally dioecious cactus, Opuntia stenopetala, are described...
  82. doi Short-term use of inhaled and intranasal corticosteroids is not associated with glaucoma progression on optical coherence tomography
    Lenworth N Johnson
    Neuro Ophthalmology Unit, Mason Eye Institute, Columbia, Missouri 65212, USA
    Eur J Ophthalmol 22:695-700. 2012
    ..To compare the changes in retinal nerve fiber layer (RNFL) thickness and optic nerve cup/disc ratio on optical coherence tomography (OCT) between users and nonusers of inhaled and intranasal corticosteroids (ICS)...
  83. doi Developing evidence-based standards for diagnosis and management of lower urinary tract or pelvic floor dysfunction
    Peter F W M Rosier
    University Medical Centre Utrecht, The Netherlands
    Neurourol Urodyn 31:621-4. 2012
    ..Implementation strategies, such as education, audit, accreditation, and research initiatives will be linked to the Standards where appropriate. Revisions of ICS Standards will be undertaken to maintain contemporaneous relevance...
  84. doi Markers for step-down of inhaled corticosteroid therapy in adult asthmatics
    Naomi Tsurikisawa
    Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18 1 Sakuradai, Minami Ku, Sagamihara, Kanagawa, Japan
    Allergol Int 61:419-29. 2012
    ..Conclusions: In asthma patients with normalized AChPC(20) of 20mg/mL or 10mg/mL and no clinical symptoms for at least 12 or 24 months it may be possible to successfully reduce ICS without increasing exacerbations for long time...
  85. pmc Untangling the Roles of Anti-Apoptosis in Regulating Programmed Cell Death using Humanized Yeast Cells
    Caitlin Clapp
    Department of Chemistry and Chemical Engineering, Royal Military College Kingston, ON, Canada
    Front Oncol 2:59. 2012
    Genetically programmed cell death (PCD) mechanisms, including apoptosis, are important for the survival of metazoans since it allows, among things, the removal of damaged cells that interfere with normal function...
  86. pmc Mutations in radial spoke head genes and ultrastructural cilia defects in East-European cohort of primary ciliary dyskinesia patients
    Ewa Zietkiewicz
    Department of Molecular and Clinical Genetics, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
    PLoS ONE 7:e33667. 2012
    Primary ciliary dyskinesia (PCD) is a rare (1/20,000), multisystem disease with a complex phenotype caused by the impaired motility of cilia/flagella, usually related to ultrastructural defects of these organelles...
  87. doi Economic impact of using inhaled corticosteroids without prior exacerbation among elderly patients with chronic obstructive pulmonary disorder
    S Chen
    United BioSource Corporation, 430 Bedford Street, Lexington, MA 02420, USA
    J Med Econ 14:458-62. 2011
    ..To assess the economic impact of initiating inhaled corticosteroids (ICS) without evidence of prior exacerbation among elderly patients with chronic obstructive pulmonary disease (COPD) in the US...
  88. doi The retina of the PCD/PCD mouse as a model of photoreceptor degeneration. A structural and functional study
    Miguel Marchena
    Department of Physiology, School of Medicine, University of Alcala, Alcala de Henares, Madrid, Spain
    Exp Eye Res 93:607-17. 2011
    In this work, we used the pcd (Purkinje cell degeneration) mutant mouse with a slow temporal progression of photoreceptor degeneration in order to analyze the structural and functional modifications in the neuronal populations of the ..
  89. doi Long-acting β-agonists in asthma management: what is the current status?
    Satya Mysore
    Department of Respiratory Medicine, The Queen Elizabeth Hospital, Woodville, SA, Australia
    Drugs 71:2091-7. 2011
    ..The same arguments apply to the asthma-with-chronic obstructive pulmonary disease overlap syndrome in older patients. There is an urgent need to provide medical practitioners with the capability to diagnose the overlap syndrome...
  90. doi Mitochondrial proteome during salt stress-induced programmed cell death in rice
    Xi Chen
    Department of Biochemistry and Molecular Biology, Nanjing Agricultural University, Weigang, China
    Plant Physiol Biochem 47:407-15. 2009
    It has been shown that mitochondria play a pivotal role in plant programmed cell death (PCD). Previous study established a salt stress-induced PCD model in rice (Oryza sativa L. cv...
  91. ncbi The safety of formoterol among patients with asthma using inhaled corticosteroids. Systematic review and meta-analysis
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Pol Arch Med Wewn 118:627-35. 2008
    ....
  92. doi Association between incidence of acute exacerbation and medication therapy in patients with COPD
    Dong Churl Suh
    Rutgers University School of Pharmacy, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Curr Med Res Opin 26:297-306. 2010
    ....
  93. doi Clinical effectiveness of inhaled corticosteroids versus montelukast in children with asthma: prescription patterns and patient adherence as key factors
    Francine M Ducharme
    Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada
    Curr Med Res Opin 28:111-9. 2012
    ..To examine the real-life effectiveness of inhaled corticosteroids (ICS) versus leukotriene receptor antagonists (LTRA) monotherapy in children with mild or moderate asthma...
  94. pmc Race-ethnic differences in factors associated with inhaled steroid adherence among adults with asthma
    Karen Wells
    Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI 48202, USA
    Am J Respir Crit Care Med 178:1194-201. 2008
    ..Adherence to inhaled corticosteroid (ICS) medication is known to be low overall, but tends to be lower among African-American patients when compared with white patients...
  95. doi Inhaled corticosteroid therapy for patients with persistent asthma: learnings from studies of inhaled budesonide
    Bradley E Chipps
    Capital Allergy and Respiratory Disease Center, Sacramento, California 95819, USA
    Allergy Asthma Proc 30:217-28. 2009
    ....
  96. pmc RNA and DNA bacteriophages as molecular diagnosis controls in clinical virology: a comprehensive study of more than 45,000 routine PCR tests
    Laetitia Ninove
    UMR190, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    PLoS ONE 6:e16142. 2011
    ..The high rate of inhibitors observed in a variety of specimen types should stimulate the elaboration of improved technical protocols for the extraction and amplification of nucleic acids...
  97. doi Impact of positive and negative beliefs about inhaled corticosteroids on adherence in inner-city asthmatic patients
    Diego Ponieman
    Division of General Internal Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Ann Allergy Asthma Immunol 103:38-42. 2009
    ..Daily inhaled corticosteroid (ICS) use is the cornerstone of asthma management, although it is often suboptimal, especially in inner-city populations...
  98. doi Relationship between exhaled nitric oxide and IgE sensitisation in patients with asthma: influence of steroid treatment
    Jörgen Syk
    Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    Clin Respir J 3:143-51. 2009
    ..The influence of the degree of immunoglobulin E (IgE) sensitisation on the fraction of expired nitric oxide (FE(NO)) in asthma patients being treated with inhaled corticosteroids (ICS) is not well known...
  99. doi Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis
    Gyunghee Lee
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA
    J Comp Neurol 519:34-48. 2011
    ..larval neurons in the Drosophila central nervous system are eliminated by developmentally programmed cell death (PCD) during early metamorphosis...
  100. ncbi Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children
    Francine M Ducharme
    Research Centre, CHU Sainte Justine and the Department of Pediatrics, University of Montreal, 3175 Cote Sainte Catherine, Montreal, , Canada, H3T 1C5
    Cochrane Database Syst Rev 5:CD005535. 2010
    ....
  101. doi Agenesis of paranasal sinuses and nasal nitric oxide in primary ciliary dyskinesia
    M Pifferi
    Dept of Paediatrics, University of Pisa, Via Roma 67 56126, Pisa, Italy
    Eur Respir J 37:566-71. 2011
    Agenesis of paranasal sinuses has only been described in case reports of patients with primary ciliary dyskinesia (PCD)...

Research Grants72

  1. Extra-Fine Inhaled Corticosteroid Effect on Distal Lung Disease in Asthma
    Michelle Zeidler; Fiscal Year: 2007
    ..This study will determine the potential to modify distal airways inflammation which may ultimately improve asthma control. ..
  2. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN FADEN; Fiscal Year: 2009
    ..The caspase-independent programmed cell death (PCD) is due in large part to the activation/translocation of apoptosis-inducing factor (AIF)...
  3. Analyses of neutrophil interaction with immune complexes
    Tanya N Mayadas; Fiscal Year: 2011
    ..We anticipate that this will lead to the identification of therapeutic strategies that target tissue injury in inflammatory and autoimmune disorders relevant to human disease. ..
  4. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010
    ..End of Abstract) ..
  5. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT SUTHERLAND; Fiscal Year: 2007
    ..End of Abstract) ..
  6. Pediatric Asthma Alert Intervention in Minority Children
    ARLENE MANNS BUTZ; Fiscal Year: 2010
    ....
  7. Pediatric Asthma Alert Intervention in Minority Children
    Arlene Butz; Fiscal Year: 2009
    ....
  8. PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMA
    Keoki Williams; Fiscal Year: 2010
    ..Knowledge gained from this study may help clinicians select asthma treatments most likely to work for their patients, as well as provide insight for future asthma therapeutics. ..
  9. PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMA
    Keoki Williams; Fiscal Year: 2009
    ..Knowledge gained from this study may help clinicians select asthma treatments most likely to work for their patients, as well as provide insight for future asthma therapeutics. ..
  10. STRUCTURAL BIOLOGY OF DIOXYGENASES
    Douglas Ohlendorf; Fiscal Year: 2003
    ..The principal target of this project has been protocatechuate 3,4-dioxygenase (3,4-PCD; Fe+3 cofactor, cleaves aromatic rings between hydroxyls) which has been used as a model system...
  11. Molecular Basis of Pathogen-Induced Cell Death in Plants
    JEAN GREENBERG; Fiscal Year: 2009
    ..approaches to examine a major signaling pathway that controls innate immunity and programmed cell death (PCD). The control of plant defenses has many parallels with human innate immunity...
  12. Molecular Basis of Pathogen-Induced Cell Death in Plants
    JEAN GREENBERG; Fiscal Year: 2007
    ..approaches to examine a major signaling pathway that controls innate immunity and programmed cell death (PCD). The control of plant defenses has many parallels with human innate immunity...
  13. Molecular Basis of Pathogen-Induced Cell Death in Plants
    JEAN GREENBERG; Fiscal Year: 2007
    ..approaches to examine a major signaling pathway that controls innate immunity and programmed cell death (PCD). The control of plant defenses has many parallels with human innate immunity...
  14. Analyses of neutrophil interaction with immune complexes
    Tanya N Mayadas; Fiscal Year: 2010
    ..We anticipate that this will lead to the identification of therapeutic strategies that target tissue injury in inflammatory and autoimmune disorders relevant to human disease. ..
  15. IDENTIFICATION OF BIOCHEMICAL ABNORMALITIES IN PCD CILIA
    LAWRENCE OSTROWSKI; Fiscal Year: 2002
    Primary ciliary dyskinesia (PCD) is an inherited disease which is characterized by various ultrastructural abnormalities in the cilia lining the respiratory tract...
  16. MOLECULAR ANALYSIS OF FLAGELLAR DYNEIN FUNCTION
    Stephen King; Fiscal Year: 1999
    ....
  17. Mechanisms of Kinase-dependent Regulation of the V-ATPase in Kidney
    NURIA M PASTOR SOLER; Fiscal Year: 2010
    ..The successful completion of the Specific Aims detailed in this application will, we believe, contribute to new strategies to treat disorders of acidification in the kidney and in the urogenital tract. ..
  18. Mechanisms of Kinase-dependent Regulation of the V-ATPase in Kidney
    Nuria Pastor Soler; Fiscal Year: 2009
    ..The successful completion of the Specific Aims detailed in this application will, we believe, contribute to new strategies to treat disorders of acidification in the kidney and in the urogenital tract. ..
  19. Conditional Deletion of Dnaic1 as a Model of Primary Ciliary Dyskinesia
    LAWRENCE OSTROWSKI; Fiscal Year: 2007
    ..Recent work has identified mutations in two ciliary proteins, DNAI1 and DNAH5, which together account for the disease in about 20% of the patients analyzed...
  20. BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULE
    George J Schwartz; Fiscal Year: 2010
    ..These studies should show how hensin and associated proteins mediate the kidney's adaptation to acid-base disturbances. ..
  21. BICARBONATE TRANSPORT BY THE MATURING RENAL TUBULE
    George Schwartz; Fiscal Year: 2007
    ..These studies should show how hensin and associated proteins mediate the kidney's adaptation to acid-base disturbances. ..
  22. ANALYSES OF LEUKOCYTE INTERACTIONS WITH IMMUNE COMPLEXES
    Tanya Mayadas; Fiscal Year: 2003
    ..Information gained from the proposed studies should contribute to our basic understanding of fundamental mechanisms modulating leukocyte trafficking in immune mediated disease. ..
  23. Apoptosis Execution Pathways in Dopaminergic Cell Death
    Jun Chen; Fiscal Year: 2007
    ..the etiology remains unknown, there is considerable evidence that supports the view that programmed cell death (PCD) contributes, at least in part, to the degeneration of dopaminergic neurons in PD...