DMBT1

Summary

Gene Symbol: DMBT1
Description: deleted in malignant brain tumors 1
Alias: GP340, SAG, SALSA, muclin, deleted in malignant brain tumors 1 protein, glycoprotein 340, gp-340, hensin, salivary agglutinin, salivary scavenger and agglutinin, surfactant pulmonary-associated D-binding protein, vomeroglandin
Species: human
Products:     DMBT1

Top Publications

  1. Mollenhauer J, Herbertz S, Helmke B, Kollender G, Krebs I, Madsen J, et al. Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer. Cancer Res. 2001;61:8880-6 pubmed
    Deleted in Malignant Brain Tumors 1 (DMBT1) has been proposed as a candidate tumor suppressor gene for brain, lung, and digestive tract cancer...
  2. Kang W, Reid K. DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration?. FEBS Lett. 2003;540:21-5 pubmed
    ..Two mucosal defense-related molecules, gp-340 and salivary agglutinin, have been identified to be alternatively spliced products of DMBT1, which suggests that DMBT1 is a pattern ..
  3. End C, Lyer S, Renner M, Stahl C, Ditzer J, Holloschi A, et al. Generation of a vector system facilitating cloning of DMBT1 variants and recombinant expression of functional full-length DMBT1. Protein Expr Purif. 2005;41:275-86 pubmed
    Deleted in malignant brain tumours 1 (DMBT1) codes for a approximately 340kDa glycoprotein with highly repetitive scavenger receptor cysteine-rich (SRCR) domains...
  4. Renner M, Bergmann G, Krebs I, End C, Lyer S, Hilberg F, et al. DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. Gastroenterology. 2007;133:1499-509 pubmed
    ..Deleted in malignant brain tumors 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein with predominant expression in the intestine and has been ..
  5. Bikker F, Ligtenberg A, End C, Renner M, Blaich S, Lyer S, et al. Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains. J Biol Chem. 2004;279:47699-703 pubmed
    ..The protein DMBT1 (deleted in malignant brain tumors 1), which is identical to salivary agglutinin and lung gp-340, belongs to the group B SRCR proteins and is considered to be involved in tumor suppression ..
  6. Ligtenberg T, Bikker F, Groenink J, Tornoe I, Leth Larsen R, Veerman E, et al. Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340. Biochem J. 2001;359:243-8 pubmed
    b>Salivary agglutinin is a 300-400 kDa salivary glycoprotein that binds to antigen B polypeptides of oral streptococci, thereby playing a role in their colonization and the development of caries...
  7. Wu Z, Van Ryk D, Davis C, Abrams W, Chaiken I, Magnani J, et al. Salivary agglutinin inhibits HIV type 1 infectivity through interaction with viral glycoprotein 120. AIDS Res Hum Retroviruses. 2003;19:201-9 pubmed
    b>Salivary agglutinin (SAG) is a high molecular mass glycoprotein (340 kDa) that plays important roles in innate immunity. SAG has been found to specifically inhibit HIV-1 infectivity and to bind to virus through the envelope protein gp120...
  8. Bikker F, Ligtenberg A, Nazmi K, Veerman E, van t Hof W, Bolscher J, et al. Identification of the bacteria-binding peptide domain on salivary agglutinin (gp-340/DMBT1), a member of the scavenger receptor cysteine-rich superfamily. J Biol Chem. 2002;277:32109-15 pubmed
    b>Salivary agglutinin is encoded by DMBT1 and identical to gp-340, a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Salivary agglutinin/DMBT1 is known for its Streptococcus mutans agglutinating properties...
  9. Mollenhauer J, Holmskov U, Wiemann S, Krebs I, Herbertz S, Madsen J, et al. The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability. Oncogene. 1999;18:6233-40 pubmed
    ..The gene DMBT1 (Deleted in Malignant Brain Tumours 1) is located at chromosome 10q25.3-q26...

More Information

Publications78

  1. Hartshorn K, Ligtenberg A, White M, van Eijk M, Hartshorn M, Pemberton L, et al. Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation. Biochem J. 2006;393:545-53 pubmed
    ..These findings may relate to inter-individual variations in innate defence against highly pathogenic IAV and to effects of aspiration of oral contents on SP-D-mediated lung functions. ..
  2. Tchatchou S, Riedel A, Lyer S, Schmutzhard J, Strobel Freidekind O, Gronert Sum S, et al. Identification of a DMBT1 polymorphism associated with increased breast cancer risk and decreased promoter activity. Hum Mutat. 2010;31:60-6 pubmed publisher
    ..Deleted in Malignant Brain Tumors 1 (DMBT1) has been proposed as a tumor suppressor for breast cancer and other cancer types...
  3. Loimaranta V, Hytönen J, Pulliainen A, Sharma A, Tenovuo J, Strömberg N, et al. Leucine-rich repeats of bacterial surface proteins serve as common pattern recognition motifs of human scavenger receptor gp340. J Biol Chem. 2009;284:18614-23 pubmed publisher
    ..Similarly, the gp340/DMBT1 protein, a member of the human scavenger receptor cysteine-rich protein family, displays a wide ligand repertoire...
  4. Mollenhauer J, Helmke B, Medina D, Bergmann G, Gassler N, Müller H, et al. Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis. Genes Chromosomes Cancer. 2004;39:185-94 pubmed
    Deleted in malignant brain tumors 1 (DMBT1) has been proposed as a candidate tumor suppressor for brain and epithelial cancer...
  5. Eriksson C, Frängsmyr L, Danielsson Niemi L, Loimaranta V, Holmskov U, Bergman T, et al. Variant size- and glycoforms of the scavenger receptor cysteine-rich protein gp-340 with differential bacterial aggregation. Glycoconj J. 2007;24:131-42 pubmed
    ..In conclusion, variant size- and glycoforms of gp-340 are expressed by different individuals and may modulate the biological properties of gp-340 pertinent to health and disease. ..
  6. Stoddard E, Cannon G, Ni H, Kariko K, Capodici J, Malamud D, et al. gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission. J Immunol. 2007;179:3126-32 pubmed
    ..To understand how HIV penetrates this barrier, we identified a host protein, gp340, that is expressed on genital epithelium and binds the HIV envelope via a specific protein-protein interaction...
  7. Wu Z, Lee S, Abrams W, Weissman D, Malamud D. The N-terminal SRCR-SID domain of gp-340 interacts with HIV type 1 gp120 sequences and inhibits viral infection. AIDS Res Hum Retroviruses. 2006;22:508-15 pubmed
    ..The expressed protein was recognized by a panel of antibodies specific for human salivary agglutinin (SAG) and the full-length parental gp340 and exhibited biological properties similar to the entire 340-kDa ..
  8. Madsen J, Mollenhauer J, Holmskov U. Review: Gp-340/DMBT1 in mucosal innate immunity. Innate Immun. 2010;16:160-7 pubmed publisher
    ..encodes a glycoprotein with a molecular mass of 340 kDa, and is referred to as gp-340 (DMBT1(gp340)) and salivary agglutinin (DMBT1(SAG))...
  9. Fukui H, Sekikawa A, Tanaka H, Fujimori Y, Katake Y, Fujii S, et al. DMBT1 is a novel gene induced by IL-22 in ulcerative colitis. Inflamm Bowel Dis. 2011;17:1177-88 pubmed publisher
    ..In this study microarray analyses revealed that deleted in malignant brain tumors 1 (DMBT1) is a novel upregulated gene in IL-22-stimulated colon cancer cells...
  10. Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus K, et al. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat Genet. 1997;17:32-9 pubmed
    ..3-26.1 in a medulloblastoma cell line and have cloned a novel gene, DMBT1, spanning this deletion. DMBT1 shows homology to the scavenger receptor cysteine-rich (SRCR) superfamily...
  11. Braidotti P, Nuciforo P, Mollenhauer J, Poustka A, Pellegrini C, Moro A, et al. DMBT1 expression is down-regulated in breast cancer. BMC Cancer. 2004;4:46 pubmed
    We studied the expression of DMBT1 (deleted in malignant brain tumor 1), a putative tumor suppressor gene, in normal, proliferative, and malignant breast epithelium and its possible relation to cell cycle...
  12. Ligtenberg A, Bikker F, de Blieck Hogervorst J, Veerman E, Nieuw Amerongen A. Binding of salivary agglutinin to IgA. Biochem J. 2004;383:159-64 pubmed
    SAG (salivary agglutinin), which is identical to gp-340 (glycoprotein-340) from the lung, is encoded by DMBT1 (deleted in malignant brain tumours 1)...
  13. Ligtenberg A, Veerman E, Nieuw Amerongen A, Mollenhauer J. Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer. Biol Chem. 2007;388:1275-89 pubmed
    b>Salivary agglutinin (SAG), lung glycoprotein-340 (gp-340) and Deleted in Malignant Brain Tumours 1 (DMBT1) are three names for identical proteins encoded by the dmbt1 gene...
  14. Bisgaard H, Holmskov U, Santoni Rugiu E, Nagy P, Nielsen O, Ott P, et al. Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1. Am J Pathol. 2002;161:1187-98 pubmed
    ..Of these, only two, namely alpha-fetoprotein and a novel transcript with high homology to human DMBT1 (deleted in malignant brain tumor 1), were specifically associated with the emergence of ductular (oval) cell ..
  15. Mollenhauer J, Helmke B, Müller H, Kollender G, Lyer S, Diedrichs L, et al. Sequential changes of the DMBT1 expression and location in normal lung tissue and lung carcinomas. Genes Chromosomes Cancer. 2002;35:164-9 pubmed
    Deleted in Malignant Brain Tumors 1 (DMBT1) at chromosome region 10q25.3-q26.1 has been proposed as a candidate tumor-suppressor gene for brain, digestive tract, and lung cancer...
  16. End C, Bikker F, Renner M, Bergmann G, Lyer S, Blaich S, et al. DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands. Eur J Immunol. 2009;39:833-42 pubmed publisher
    Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum...
  17. Prakobphol A, Xu F, Hoang V, Larsson T, Bergstrom J, Johansson I, et al. Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340. J Biol Chem. 2000;275:39860-6 pubmed
    b>Salivary agglutinin is a high molecular mass component of human saliva that binds Streptococcus mutans, an oral bacterium implicated in dental caries. To study its protein sequence, we isolated the agglutinin from human parotid saliva...
  18. Tino M, Wright J. Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner. Am J Respir Cell Mol Biol. 1999;20:759-68 pubmed
    ..These results suggest that gp-340 is not a cell-surface receptor necessary for SP-A stimulation of chemotaxis, and show that gp-340 can directly affect macrophage function. ..
  19. Leito J, Ligtenberg A, van Houdt M, van den Berg T, Wouters D. The bacteria binding glycoprotein salivary agglutinin (SAG/gp340) activates complement via the lectin pathway. Mol Immunol. 2011;49:185-90 pubmed publisher
    b>Salivary agglutinin (SAG), also known as gp-340 and Deleted in Malignant Brain Tumours 1, is a glycoprotein that is present in tears, lung fluid and mucosal surfaces along the gastrointestinal tract...
  20. Holmskov U, Lawson P, Teisner B, Tornoe I, Willis A, Morgan C, et al. Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule. J Biol Chem. 1997;272:13743-9 pubmed
    ..We conclude that gp-340 is a new member of the scavenger-receptor superfamily and likely to be a truncated form of a receptor for SP-D. ..
  21. Lei H, Hemminki K, Johansson R, Altieri A, Enquist K, Henriksson R, et al. Single nucleotide polymorphisms in the DMBT1 promoter and the progression of breast cancer. Int J Cancer. 2007;120:447-9 pubmed
  22. Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, et al. Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion. J Immunol. 2007;178:8203-11 pubmed
    ..Deleted in malignant brain tumors 1 (DMBT1) belongs to the group of secreted scavenger receptor cysteine-rich proteins and is considered to be involved in ..
  23. Edwards A, Manetti A, Falugi F, Zingaretti C, Capo S, Buccato S, et al. Scavenger receptor gp340 aggregates group A streptococci by binding pili. Mol Microbiol. 2008;68:1378-94 pubmed publisher
    ..Further studies revealed that aggregating bacteria bound salivary component gp340. Purified gp340 aggregated wild-type GAS and L. lactis expressing GAS pili, but not control strains...
  24. Bikker F, Ligtenberg A, van der Wal J, van den Keijbus P, Holmskov U, Veerman E, et al. Immunohistochemical detection of salivary agglutinin/gp-340 in human parotid, submandibular, and labial salivary glands. J Dent Res. 2002;81:134-9 pubmed
    b>Salivary agglutinin is a Streptococcus mutans binding protein and a member of the scavenger receptor cysteine-rich superfamily...
  25. Takeshita H, Sato M, Shiwaku H, Semba S, Sakurada A, Hoshi M, et al. Expression of the DMBT1 gene is frequently suppressed in human lung cancer. Jpn J Cancer Res. 1999;90:903-8 pubmed
    b>DMBT1 (deleted in malignant brain tumors) is a candidate tumor suppressor gene that has been mapped to chromosome 10q25.3-q26.1, a region in which frequent loss of heterozygosity (LOH) has been observed in several human tumors...
  26. Mori M, Shiraishi T, Tanaka S, Yamagata M, Mafune K, Tanaka Y, et al. Lack of DMBT1 expression in oesophageal, gastric and colon cancers. Br J Cancer. 1999;79:211-3 pubmed
    ..Recently, a second candidate tumour-suppressor gene, DMBT1, was identified in this chromosomal region...
  27. Diegelmann J, Olszak T, Goke B, Blumberg R, Brand S. A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory p. J Biol Chem. 2012;287:286-98 pubmed publisher
    ..The IL-27-induced expression of the anti-bacterial gene deleted in malignant brain tumor 1 (DMBT1) is mediated by p38 and STAT3 signaling, whereas the activation of the anti-inflammatory and anti-bacterial gene ..
  28. Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, et al. Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. Proc Natl Acad Sci U S A. 1999;96:10794-9 pubmed
    ..gp-340 seems to be an alternative spliced form of DMBT1. Reverse transcription-PCR analysis showed that the main sites of synthesis of gp-340 are lung, trachea, salivary ..
  29. Rossez Y, Coddeville B, Elass E, Quinchon J, Vidal O, Corfield A, et al. Interaction between DMBT1 and galectin 3 is modulated by the structure of the oligosaccharides carried by DMBT1. Biochimie. 2011;93:593-603 pubmed publisher
    ..It has been shown previously that interaction of hensin, the rabbit ortholog of DMBT1, with galectin 3, a ?-galactoside-binding lectin, induces a terminal differentiation ..
  30. Mueller W, Mollenhauer J, Stockhammer F, Poustka A, von Deimling A. Rare mutations of the DMBT1 gene in human astrocytic gliomas. Oncogene. 2002;21:5956-9 pubmed
    The Deleted in Malignant Brain Tumors 1 gene (DMBT1) has been proposed as a tumor suppressor gene candidate in human brain tumors, based on the observation of homozygous deletions affecting the DMBT1 region or part of the gene...
  31. Mollenhauer J, Müller H, Kollender G, Lyer S, Diedrichs L, Helmke B, et al. The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer. Genes Chromosomes Cancer. 2002;35:242-55 pubmed
    Deleted in malignant brain tumors 1 (DMBT1) at 10q25.3-q26.1 has been proposed as a candidate tumor-suppressor gene for brain and epithelial cancer...
  32. Hartshorn K, White M, Mogues T, Ligtenberg T, Crouch E, Holmskov U. Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1066-76 pubmed
    ..Furthermore, removal of gp-340 from BAL fluid and saliva significantly reduced anti-IAV activity. Hence, gp-340 contributes to defense against IAV and may be particularly relevant to defense against SP-D-resistant viral strains. ..
  33. Wu Z, Golub E, Abrams W, Malamud D. gp340 (SAG) binds to the V3 sequence of gp120 important for chemokine receptor interaction. AIDS Res Hum Retroviruses. 2004;20:600-7 pubmed
    ..b>Salivary agglutinin (SAG) is a high-molecular-weight glycoprotein encoded by DMBT-1 and identical to gp340, a member of the ..
  34. Gao C, Devarajan K, Zhou Y, Slater C, Daly M, Chen X. Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome. BMC Genomics. 2012;13:570 pubmed publisher
    ..31, P = 0.0018, FDR = 0.040) and USP6 (DASE = 4.80, P = 0.0013, FDR = 0.013), and a breast cancer causative gene, DMBT1 (DASE=2.03, P = 0.0017, FDR = 0.014)...
  35. Chen C, Rao S, Ren L, Hu X, Tan Y, Hu Y, et al. Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis. Theranostics. 2018;8:1607-1623 pubmed publisher
    ..Particularly, a pro-angiogenic protein called deleted in malignant brain tumors 1 (DMBT1) was highly expressed in USC-Exos...
  36. Dodurga Y, Avci C, Satiroglu Tufan N, Tataroglu C, Kesen Z, Dogan Z, et al. Detection of deleted in malignant brain tumors 1 and runt-related transcription factor 3 gene expressions in bladder carcinoma. Mol Biol Rep. 2012;39:4691-5 pubmed publisher
    ..Deleted in malignant brain tumors 1 (DMBT1) gene is located at chromosome 10q25.3-q26.1...
  37. Petersen C, Weis V, Nam K, Sousa J, Fingleton B, Goldenring J. Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. Gastroenterology. 2014;146:1727-38.e8 pubmed publisher
    ..To characterize SPEM in each model, gastric tissues were collected and levels of Cftr, Dmbt1, and Gpx2 mRNAs were measured...
  38. Polley S, Louzada S, Forni D, Sironi M, Balaskas T, Hains D, et al. Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy. Proc Natl Acad Sci U S A. 2015;112:5105-10 pubmed publisher
    ..b>Salivary agglutinin [SAG, encoded by the deleted in malignant brain tumors 1 (DMBT1) gene] is an innate immune receptor ..
  39. Bikker F, End C, Ligtenberg A, Blaich S, Lyer S, Renner M, et al. The scavenging capacity of DMBT1 is impaired by germline deletions. Immunogenetics. 2017;69:401-407 pubmed publisher
    ..Deleted in Malignant Brain Tumors 1 (DMBT1) is a SRCR protein which is secreted in mucosal fluids and involved in host defense by pathogen binding by its ..
  40. Schulten H, Bangash M, Karim S, Dallol A, Hussein D, Merdad A, et al. Comprehensive molecular biomarker identification in breast cancer brain metastases. J Transl Med. 2017;15:269 pubmed publisher
    ..g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1, CASP14, CDC25A, DMBT1, IDH2, E2F1, MYCN, RAD51, RAD54L, and VDR...
  41. Tynan S, Pacia E, Haynes Johnson D, Lawrence D, D Andrea M, Guo J, et al. The putative tumor suppressor deleted in malignant brain tumors 1 is an estrogen-regulated gene in rodent and primate endometrial epithelium. Endocrinology. 2005;146:1066-73 pubmed
    Deleted in malignant brain tumors 1 (DMBT1) is a candidate suppressor of malignancies of the brain, lung, gut, and breast. We have been studying gene expression in the uterus in the presence of estrogens and their antagonists...
  42. Schulz B, Oxley D, Packer N, Karlsson N. Identification of two highly sialylated human tear-fluid DMBT1 isoforms: the major high-molecular-mass glycoproteins in human tears. Biochem J. 2002;366:511-20 pubmed
    ..By peptide-mass fingerprinting after tryptic digestion, the proteins were found to be isoforms of the DMBT1 gene product, with over 30% of the predicted protein covered by the tryptic peptides...
  43. Polley S, Prescott N, Nimmo E, Veal C, Vind I, Munkholm P, et al. Copy number variation of scavenger-receptor cysteine-rich domains within DMBT1 and Crohn's disease. Eur J Hum Genet. 2016;24:1294-300 pubmed publisher
    Previous work has shown that the gene DMBT1, which encodes a large secreted epithelial glycoprotein known as salivary agglutinin, gp340, hensin or muclin, is an innate immune defence protein that binds bacteria...
  44. Kang W, Nielsen O, Fenger C, Leslie G, Holmskov U, Reid K. Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer. Carcinogenesis. 2005;26:1129-37 pubmed
    Abnormalities in the expression of DMBT1 (deleted in malignant brain tumors 1) have been implicated in the development of esophageal, gastric and colorectal cancers of the alimentary tract, but the underlying mechanism remains unclear...
  45. Otieno M, Bhaskaran V, Janovitz E, Callejas Y, Foster W, Washburn W, et al. Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1). Toxicol Sci. 2017;155:379-388 pubmed publisher
    ..changes in hepatic transporters and induction of oval cell-specific genes including deleted malignant tumor 1 (Dmbt1)...
  46. Ren S, Chen X, Jiang L, Zhu B, Jiang Q, Xi X. Deleted in malignant brain tumors 1 protein is a potential biomarker of acute respiratory distress syndrome induced by pneumonia. Biochem Biophys Res Commun. 2016;478:1344-9 pubmed publisher
    ..plasma expression of pulmonary surfactant associated protein A, apolipoprotein A1, and deleted in malignant brain tumors 1 protein (DMBT1) was verified in plasma samples...
  47. Stoddard E, Ni H, Cannon G, Zhou C, Kallenbach N, Malamud D, et al. gp340 promotes transcytosis of human immunodeficiency virus type 1 in genital tract-derived cell lines and primary endocervical tissue. J Virol. 2009;83:8596-603 pubmed publisher
    The human scavenger receptor gp340 has been identified as a binding protein for the human immunodeficiency virus type 1 (HIV-1) envelope that is expressed on the cell surface of female genital tract epithelial cells...
  48. Mollenhauer J, Helmke B, Müller H, Kollender G, Krebs I, Wiemann S, et al. An integrative model on the role of DMBT1 in epithelial cancer. Cancer Detect Prev. 2002;26:266-74 pubmed
    The gene, deleted in malignant brain tumors 1 (DMBT1), has been proposed to play a role in brain and epithelial cancer, but shows unusual features for a classical tumor suppressor gene...
  49. Polley S, Cipriani V, Khan J, Shahid H, Moore A, Yates J, et al. Analysis of copy number variation at DMBT1 and age-related macular degeneration. BMC Med Genet. 2016;17:44 pubmed publisher
    b>DMBT1 is a gene that shows extensive copy number variation (CNV) that alters the number of bacteria-binding domains in the protein and has been shown to activate the complement pathway...
  50. Cheung W, Darfler M, Alvarez H, Hood B, Conrads T, Habbe N, et al. Application of a global proteomic approach to archival precursor lesions: deleted in malignant brain tumors 1 and tissue transglutaminase 2 are upregulated in pancreatic cancer precursors. Pancreatology. 2008;8:608-16 pubmed publisher
    ..Immunohistochemical analysis for two of these, deleted in malignant brain tumors 1 (DMBT1) and tissue transglutaminase 2 (TGM2), confirmed their overexpression in IPMNs...
  51. Chu Y, Li J, Wu X, Hua Z, Wu Z. Identification of human immunodeficiency virus type 1 (HIV-1) gp120-binding sites on scavenger receptor cysteine rich 1 (SRCR1) domain of gp340. J Biomed Sci. 2013;20:44 pubmed publisher
    gp340, a member of scavenger receptor cysteine rich family encoded by Deleted in Malignant Brain Tumors 1 (DMBT1), is an important component in innate immune defense...
  52. Strömberg N, Esberg A, Sheng N, Mårell L, Löfgren Burström A, Danielsson K, et al. Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2. EBioMedicine. 2017;26:38-46 pubmed publisher
    ..accumulation in general when treated with orthodontic multibrackets; and had basic PRP polymorphisms and low DMBT1-mediated S. mutans adhesion as additional susceptibility traits...
  53. Deichmann M, Mollenhauer J, Helmke B, Thome M, Hartschuh W, Poustka A, et al. Analysis of losses of heterozygosity of the candidate tumour suppressor gene DMBT1 in melanoma resection specimens. Oncology. 2002;63:166-72 pubmed
    Deleted in malignant brain tumours 1 (DMBT1), a candidate tumour suppressor gene located on chromosome 10q25.3-q26.1, has recently been identified and found to be deleted in several different types of human tumours...
  54. Reichhardt M, Holmskov U, Meri S. SALSA-A dance on a slippery floor with changing partners. Mol Immunol. 2017;89:100-110 pubmed publisher
    ..Amongst others these include the complement system, IgA and the SALSA molecule. The salivary scavenger and agglutinin (SALSA), also known as deleted in malignant brain tumors 1 (DMBT1), salivary agglutinin (SAG) or ..
  55. Wessels P, Twijnstra A, Kubat B, Ummelen M, Claessen S, Sciot R, et al. 10q25.3 (DMBT1) copy number changes in astrocytoma grades II and IV. Genes Chromosomes Cancer. 2004;39:22-8 pubmed
    In the literature, it has been suggested that loss of the 10q25-26 region, including the DMBT1 gene (10q25...
  56. Roldán M, Teijeiro J, Álvarez J, Marini P. Sperm binding to porcine oviductal cells is mediated by SRCR domains contained in DMBT1. J Cell Biochem. 2017;: pubmed publisher
    ..proteins have been identified in relation to sperm binding, Annexin A2 and Deleted in Malignant Brain Tumour 1 (DMBT1)...
  57. Müller H, Nagel C, Weiss C, Mollenhauer J, Poeschl J. Deleted in malignant brain tumors 1 (DMBT1) elicits increased VEGF and decreased IL-6 production in type II lung epithelial cells. BMC Pulm Med. 2015;15:32 pubmed publisher
    Deleted in malignant brain tumors 1 (DMBT1) is an innate defence protein expressed in the lungs of preterm infants and adults...
  58. Cannon G, Yi Y, Ni H, Stoddard E, Scales D, Van Ryk D, et al. HIV envelope binding by macrophage-expressed gp340 promotes HIV-1 infection. J Immunol. 2008;181:2065-70 pubmed
    The scavenger receptor cysteine-rich protein gp340 functions as part of the host innate immune defense system at mucosal surfaces...
  59. Garay J, Piazuelo M, Lopez Carrillo L, Leal Y, Majumdar S, Li L, et al. Increased expression of deleted in malignant brain tumors (DMBT1) gene in precancerous gastric lesions: Findings from human and animal studies. Oncotarget. 2017;8:47076-47089 pubmed publisher
    ..Deleted in malignant brain tumors 1 (DMBT1) belongs to the group of secreted scavenger receptor cysteine-rich proteins and is considered to be involved in ..
  60. Ma J, Takito J, Vijayakumar S, Peehl D, Olsson C, Al Awqati Q. Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation. Prostate. 2001;49:9-18 pubmed
    b>Hensin induces terminal differentiation in rabbit kidney collecting tubule cells. Rabbit hensin and human DMBT1 result from alternative splicing of the same gene...
  61. Lu X, Xu Y, Zhao Y, Tao Q, Wu J. Silenced DMBT1 promotes nasal mucosa epithelial cell growth. Ann Hum Genet. 2017;: pubmed publisher
    The aim of this study was to investigate the role of the deleted in malignant brain tumors 1 (DMBT1) gene in the development of nasal polyps, as well as related mechanisms.
  62. Tuttolomondo M, Casella C, Hansen P, Polo E, Herda L, Dawson K, et al. Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery. Mol Ther Nucleic Acids. 2017;8:264-276 pubmed publisher
    ..Human protein DMBT1 (deleted in malignant brain tumor 1) is a pattern recognition molecule that interacts with polyanions and ..
  63. Agerholm J, McEvoy F, Heegaard S, Charlier C, Jagannathan V, Drogemuller C. A de novo missense mutation of FGFR2 causes facial dysplasia syndrome in Holstein cattle. BMC Genet. 2017;18:74 pubmed publisher
    ..of a case-parent trio revealed two de novo variants perfectly associated with the disease: an intronic SNP in the DMBT1 gene and a single non-synonymous variant in the FGFR2 gene. This FGFR2 missense variant (c...
  64. Sasaki M, Tsuneyama K, Saito T, Kataoka H, Mollenhauer J, Poustka A, et al. Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology. Liver Int. 2004;24:29-37 pubmed
    ..In this study, the significance of TFF family and deleted in the malignant brain tumor-1 (DMBT1), a putative receptor of TFF2, in the intrahepatic biliary tree was investigated in normal and diseased livers...
  65. Gunput S, Wouters D, Nazmi K, Cukkemane N, Brouwer M, Veerman E, et al. Salivary agglutinin is the major component in human saliva that modulates the lectin pathway of the complement system. Innate Immun. 2016;22:257-65 pubmed publisher
    Saliva interacts with blood after mucosal damage or leakage of gingival crevicular fluid. Surface-adsorbed salivary agglutinin (SAG) activates the lectin pathway (LP) of the complement system via mannose-binding lectin, while SAG in ..
  66. Müller H, End C, Renner M, Helmke B, Gassler N, Weiss C, et al. Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant. Respir Res. 2007;8:69 pubmed
    Deleted in Malignant Brain Tumors 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds various bacteria and is thought to participate in innate pulmonary host defense...
  67. Robbe C, Paraskeva C, Mollenhauer J, Michalski J, Sergi C, Corfield A. DMBT1 expression and glycosylation during the adenoma-carcinoma sequence in colorectal cancer. Biochem Soc Trans. 2005;33:730-2 pubmed
    The gene DMBT1 (deleted in malignant brain tumour-1) has been proposed to play a role in brain and epithelial cancer, but shows unusual features for a classical tumour-suppressor gene...
  68. Rasheed B, McLendon R, Friedman H, Friedman A, Fuchs H, Bigner D, et al. Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Oncogene. 1995;10:2243-6 pubmed
    ..In the 15 tumors with deletions in 10q, the minimal overlapping deletion region was in distal 10q between markers D10S587 and D10S216. Loci D10S587 and D10S216 are approximately mapped to a 5 cM region in 10q25.1. ..
  69. Deng H, Gao Y, Wang H, Jin X, Xiao J. Expression of deleted in malignant brain tumours 1 (DMBT1) relates to the proliferation and malignant transformation of hepatic progenitor cells in hepatitis B virus-related liver diseases. Histopathology. 2012;60:249-60 pubmed publisher
    ..of this study was to evaluate the correlation between the expression of deleted in malignant brain tumours 1 (DMBT1) and the biological behaviour of HPCs in different hepatitis B virus (HBV)-related human liver diseases...