Gene Symbol: DMAP1
Description: DNA methyltransferase 1 associated protein 1
Alias: DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4, DNA methyltransferase 1-associated protein 1, DNMT1 associated protein 1
Species: human
Products:     DMAP1

Top Publications

  1. Doyon Y, Selleck W, Lane W, Tan S, Cote J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol. 2004;24:1884-96 pubmed
    ..We also demonstrate that subunits MRG15 and DMAP1 are present in distinct protein complexes harboring histone deacetylase and SWI2-related ATPase activities, ..
  2. Cai Y, Jin J, Florens L, Swanson S, Kusch T, Li B, et al. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. J Biol Chem. 2005;280:13665-70 pubmed
    ..Taken together, our findings identify the YL1 protein as a new subunit of the TRRAP/TIP60 HAT complex, and they suggest that YL1 plays multiple roles in chromatin modification and remodeling in cells. ..
  3. Kvaløy K, Page C, Holmen T. Epigenome-wide methylation differences in a group of lean and obese women - A HUNT Study. Sci Rep. 2018;8:16330 pubmed publisher
    ..differentially methylated CpG sites linked to 8 gene loci - COX6A1P2/FGD2, SBNO2, TEX41, RPS6KA2, IGHE/IGHG1/IGHD, DMAP1, SOCS3, and SETBP1- and an enhancer locus at chromosome 2 (2p25.1)...
  4. Nie E, Miao F, Jin X, Wu W, Zhou X, Zeng A, et al. Fstl1/DIP2A/MGMT signaling pathway plays important roles in temozolomide resistance in glioblastoma. Oncogene. 2018;: pubmed publisher
    ..As a multifunctional protein widely distributed in cells, DIP2A cooperates with the HDAC2-DMAP1 complex to enhance H3K9Ac deacetylation, prevent MGMT transcription, and increase temozolomide sensitivity...
  5. Li J, Hu B, Wang T, Huang W, Ma C, Zhao Q, et al. C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer. Mol Cancer. 2018;17:174 pubmed publisher
    ..Here, we show DMAP1/Bub3 complex mediates mitotic stress-induced cellular apoptosis, while this effect is counteracted by c-Src in ..
  6. Noblett N, Wu Z, Ding Z, Park S, Roenspies T, Flibotte S, et al. DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. J Cell Biol. 2019;218:125-133 pubmed publisher
    ..The conserved disco-interacting protein 2 (DIP2) consists of a DMAP1-binding domain and two adenylate-forming domains (AFDs)...
  7. Bieluszewski T, Galganski L, Sura W, Bieluszewska A, Abram M, Ludwikow A, et al. AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. BMC Plant Biol. 2015;15:75 pubmed publisher
    ..AtEAF1 copurifies with Arabidopsis homologues of NuA4 and SWR1-C subunits ARP4 and SWC4 and interacts physically with AtYAF9A and AtYAF9B, homologues of the YAF9 subunit...
  8. Feng K, Guo H. Eaf2 protects human lens epithelial cells against oxidative stress?induced apoptosis by Wnt signaling. Mol Med Rep. 2018;17:2795-2802 pubmed publisher
    The tumor suppressor protein ELL-associated factor 2 (Eaf2) serves an important role in lens development and maturation; however, its role in oxidative stress?induced cataract formation remains unclear...
  9. Guo W, Keener A, Jing Y, Cai L, Ai J, Zhang J, et al. FOXA1 modulates EAF2 regulation of AR transcriptional activity, cell proliferation, and migration in prostate cancer cells. Prostate. 2015;75:976-87 pubmed publisher
    ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor in the prostate. However, the mechanisms underlying tumor suppressive function of EAF2 are still largely unknown...

More Information


  1. van Keimpema M, Grüneberg L, Mokry M, van Boxtel R, Koster J, Coffer P, et al. FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells. Blood. 2014;124:3431-40 pubmed publisher
    ..the BH3-only proteins BIK and Harakiri, the p53-regulatory proteins TP63, RASSF6, and TP53INP1, and AIM2 and EAF2, is associated with poor survival in DLBCL patients...
  2. Pascal L, Wang Y, Zhong M, Wang D, Chakka A, Yang Z, et al. EAF2 and p53 Co-Regulate STAT3 Activation in Prostate Cancer. Neoplasia. 2018;20:351-363 pubmed publisher
    The tumor suppressor genes EAF2 and p53 are frequently dysregulated in prostate cancers. Recently, we reported that concurrent p53 nuclear staining and EAF2 downregulation were associated with high Gleason score...
  3. Qiu X, Pascal L, Song Q, Zang Y, Ai J, O Malley K, et al. Physical and Functional Interactions between ELL2 and RB in the Suppression of Prostate Cancer Cell Proliferation, Migration, and Invasion. Neoplasia. 2017;19:207-215 pubmed publisher
    ..ELL2 and ELL-associated factor 2 (EAF2) form a stable complex, and their orthologs in Caenorhabditis elegans appear to be functionally similar. In C...
  4. Pang B, Zheng X, Tian J, Gao T, Gu G, Zhang R, et al. EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1? signaling. Oncotarget. 2016;7:45134-45143 pubmed publisher
    ..EZH2 suppressed expression of EAF2, which in turn upregulated HIF1? levels...
  5. Zang Y, Dong Y, Yang D, Xue B, Li F, Gu P, et al. Expression and prognostic significance of ELL-associated factor 2 in human prostate cancer. Int Urol Nephrol. 2016;48:695-700 pubmed publisher
    ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor in the prostate...
  6. Jiang Y, Fu R, Zhao J, Wu D, Qiao G, Li R, et al. Effects of ELL-associated factor 2 on ultraviolet radiation-induced cataract formation in mice. Mol Med Rep. 2015;12:6605-11 pubmed publisher
    ELL-associated factor 2 (Eaf2) has an important role in crystalline lens development and maturation; however, its role in ultraviolet radiation (UV)-induced cataract formation has remained elusive...
  7. Liu X, Chen Z, Ouyang G, Song T, Liang H, Liu W, et al. ELL Protein-associated Factor 2 (EAF2) Inhibits Transforming Growth Factor β Signaling through a Direct Interaction with Smad3. J Biol Chem. 2015;290:25933-45 pubmed publisher
    A series of in vitro and in vivo studies has shown that EAF2 can affect multiple signaling pathways involved in cellular processes. However, the molecular mechanisms underlying its effects have remained elusive...
  8. Ai J, Pascal L, Wei L, Zang Y, Zhou Y, Yu X, et al. EAF2 regulates DNA repair through Ku70/Ku80 in the prostate. Oncogene. 2017;36:2054-2065 pubmed publisher
    ..ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor and its intracellular localization can be modulated by ultraviolet light,..
  9. Gómez Zambrano A, Crevillen P, Franco Zorrilla J, Lopez J, Moreno Romero J, Roszak P, et al. Arabidopsis SWC4 Binds DNA and Recruits the SWR1 Complex to Modulate Histone H2A.Z Deposition at Key Regulatory Genes. Mol Plant. 2018;11:815-832 pubmed publisher
    ..Here we show that SWC4, the Arabidopsis homolog of yeast SANT domain protein Swc4/Eaf2, is a DNA-binding protein that interacts with SWR1-C subunits...
  10. Li Y, Takahashi Y, Fujii S, Zhou Y, Hong R, Suzuki A, et al. EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity. Nat Commun. 2016;7:10836 pubmed publisher
    ..ELL-associated factor 2 (EAF2) regulates transcription elongation and has been shown to be an androgen-responsive potential tumour suppressor in ..
  11. Kokosar M, Benrick A, Perfilyev A, Fornes R, Nilsson E, Maliqueo M, et al. Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome. Sci Rep. 2016;6:22883 pubmed publisher
    ..difference (CYP1B1, GPT), genes linked to PCOS (RAB5B) or type 2 diabetes (PPARG, SVEP1), and methylation (DMAP1) were replicated in a separate case-control study. In total, 63,213 sites (P < 0.05) and 440 sites (Q < 0...
  12. Khan I, Senthilkumar C, Upadhyay N, Singh H, Sachdeva M, Jatawa S, et al. In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas- Tragedy survivors. Asian Pac J Cancer Prev. 2015;16:7663-70 pubmed
    ..investigated the interaction of MIC and its hydrolytic product (1,3-dimethylurea) with DNMT1 interacting (such as DMAP1, RFTS, and CXXC) and catalytic (SAM, SAH, and Sinefungin) domains using computer simulations...
  13. Yu X, Ai J, Cai L, Jing Y, Wang D, Dong J, et al. Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells. Oncotarget. 2016;7:29245-54 pubmed publisher
    RNA Polymerase II Elongation Factor (ELL)-associated factor 2 (EAF2) is a tumor suppressor frequently down-regulated in human prostate cancer...
  14. Monies D, Abouelhoda M, AlSayed M, Alhassnan Z, Alotaibi M, Kayyali H, et al. The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes. Hum Genet. 2017;136:921-939 pubmed publisher
  15. Yang C, Weiner H. Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol. Arch Biochem Biophys. 2002;400:105-10 pubmed
    ..Tom34 appears not to be a member of the mitochondrial outer membrane translocase family but might function as a chaperone-like protein during protein translocation. ..
  16. Xiang J, Luo F, Chen Y, Zhu F, Wang J. si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma. Clin Res Hepatol Gastroenterol. 2014;38:181-9 pubmed publisher
    ..These results may provide insight for the development of novel therapies for cholangiocarcinoma. ..
  17. Cai Y, Jin J, Tomomori Sato C, Sato S, Sorokina I, Parmely T, et al. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. J Biol Chem. 2003;278:42733-6 pubmed
    ..proteins from HeLa cell nuclear extracts, we identify the thyroid receptor coactivating protein (TRCp120), DMAP1, and the related MRG15 and MRGX proteins as MRGBP-associating proteins, and we present biochemical evidence that ..
  18. Liu Z, Fisher R. RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity. J Biol Chem. 2004;279:14120-8 pubmed
    ..We undertook a yeast two-hybrid screen for nuclear RGS6-binding proteins and here identify DMAP1 as an RGS6-interacting protein...
  19. Kang B, Shin J, Yi J, Kang H, Lee J, Heo H, et al. Corepressor MMTR/DMAP1 is involved in both histone deacetylase 1- and TFIIH-mediated transcriptional repression. Mol Cell Biol. 2007;27:3578-88 pubmed
    ..MMTR orthologs (DMAP1) are found in a wide variety of life forms from yeasts to humans...
  20. Xin H, Yoon H, Singh P, Wong J, Qin J. Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells. J Biol Chem. 2004;279:9539-46 pubmed that the p33ING1-Sin3-HDAC complex as well as DNA methyltransferase 1 (DNMT1) and DNMT1-associated protein 1 (DMAP1) are components of a pathway required for maintaining proper histone modification and heterochromatin protein 1 ..
  21. Muromoto R, Sugiyama K, Takachi A, Imoto S, Sato N, Yamamoto T, et al. Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. J Immunol. 2004;172:2985-93 pubmed
    ..DNA methyltransferase 1 (DNMT1)-associated protein (DMAP1) was identified and demonstrated to interact with Daxx...
  22. Doyon Y, Cote J. The highly conserved and multifunctional NuA4 HAT complex. Curr Opin Genet Dev. 2004;14:147-54 pubmed
    ..Recent studies presented here have established its remarkable structural conservation from yeast to human cells and contributed to the understanding of its diverse functions. ..
  23. Liu J, Xu Q, Li S, Yu X, Liu W, Ouyang G, et al. Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-? signaling. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1103-1116 pubmed publisher
    ..of gene expression profiles in Eaf deleted or over-expressed mammalian cells indicated that the roles of Eaf1 and Eaf2 in inhibiting TGF-? signals were conserved from fish to mammals...
  24. Drazevic E, Kosutić K, Svalina M, Catalano J. Permeability of uncharged organic molecules in reverse osmosis desalination membranes. Water Res. 2017;116:13-22 pubmed publisher
    ..and RO permeabilities of ten organic solutes in water-swollen active layers of two types of RO membranes, low (SWC4+) and high flux (XLE)...
  25. Wang K, Liang Q, Li X, Tsoi H, Zhang J, Wang H, et al. MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome. Gut. 2016;65:1619-31 pubmed publisher
    ..001). The anti-tumorigenic effect of MDGA2 was mediated through direct stabilising of DNA methyltransferase 1 associated protein 1 (DMAP1), which played a tumour suppressive role in gastric cancer...
  26. Negishi M, Chiba T, Saraya A, Miyagi S, Iwama A. Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process. Genes Cells. 2009;14:1347-57 pubmed publisher
    ..Dnmt1-associated protein 1 (Dmap1), a component of the NuA4 histone acetyltransferase complex, was originally identified as an interacting molecule ..
  27. Chen C, Chen W, Wang W, Lu C, Lin P, Lee K, et al. Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance. Head Neck. 2011;33:1132-43 pubmed publisher
    ..DNMT1 may be a significant clinical predictor and a potential treatment strategy against head and neck cancer. ..
  28. LEE G, Kim J, Taylor M, Muller M. DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair. J Biol Chem. 2010;285:37630-40 pubmed publisher
    ..b>DMAP1, a DNMT1 interacting protein, was identified as a mediator of this process...
  29. Wang Y, Pascal L, Zhong M, Ai J, Wang D, Jing Y, et al. Combined Loss of EAF2 and p53 Induces Prostate Carcinogenesis in Male Mice. Endocrinology. 2017;158:4189-4205 pubmed publisher
    ..ELL-associated factor 2 (EAF2) is a tumor suppressor that is frequently downregulated in advanced prostate cancer...
  30. Bönisch C, Schneider K, Pünzeler S, Wiedemann S, Bielmeier C, Bocola M, et al. H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. Nucleic Acids Res. 2012;40:5951-64 pubmed
    ..Our findings enrich the list of known human variants by an unusual protein belonging to the H2A.Z family that leads to the least stable nucleosome known to date. ..
  31. Penicud K, Behrens A. DMAP1 is an essential regulator of ATM activity and function. Oncogene. 2014;33:525-31 pubmed publisher
    ..DNMT1-associated protein 1 (DMAP1) is a member of the TIP60-p400 histone acetyl transferase (HAT) complex, which acetylates histone H4 at lysine 16 (..
  32. Cimadamore F, Amador Arjona A, Chen C, Huang C, Terskikh A. SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors. Proc Natl Acad Sci U S A. 2013;110:E3017-26 pubmed publisher
    ..In conclusion, we discovered the SOX2-LIN28/let-7 pathway as a unique molecular mechanism governing NPC proliferation and neurogenic potential. ..
  33. Zhao L, Loewenstein P, Green M. Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain. Virology. 2016;499:178-184 pubmed publisher
    ..243R (E1A 1-80) and showed that E1A 1-80 interacts with TRRAP, p400, and three other members of the NuA4 complex - DMAP1, RUVBL1 and RUVBL2 - not previously shown to associate with E1A 243R...
  34. Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy L, Murakami S. Subcellular localization of RPB5-mediating protein and its putative functional partner. Mol Cell Biol. 2004;24:8556-66 pubmed
    ..Using a yeast two-hybrid method, we isolated a putative corepressor, DNA methyltransferase 1-associating protein (DMAP1), which was found to bind to the CC domain of RMP...
  35. Shin J, Kang H, Park Y, Ha D, Choi Y, Eum H, et al. Corepressor MMTR/DMAP1 is an intrinsic negative regulator of CAK kinase to regulate cell cycle progression. Biochem Biophys Res Commun. 2010;402:110-5 pubmed publisher
    ..Our data support the notion that MMTR is an intrinsic negative cell cycle regulator that modulates the CAK kinase activity via interaction with MAT1. ..
  36. Rountree M, Bachman K, Baylin S. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet. 2000;25:269-77 pubmed
    ..The non-catalytic amino terminus of DNMT1 binds to HDAC2 and a new protein, DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression...
  37. Pascal L, Masoodi K, Liu J, Qiu X, Song Q, Wang Y, et al. Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia. J Endocrinol. 2017;235:123-136 pubmed publisher
    ..II elongation factor with functional properties similar to ELL that can interact with the prostate tumor suppressor EAF2. In the prostate, ELL2 is an androgen response gene that is upregulated in benign prostatic hyperplasia (BPH)..
  38. Muromoto R, Sugiyama K, Yamamoto T, Oritani K, Shimoda K, Matsuda T. Physical and functional interactions between Daxx and TSG101. Biochem Biophys Res Commun. 2004;316:827-33 pubmed
    ..Recently, we identified DMAP1, a TSG101-interacting protein as a Daxx binding partner by yeast two-hybrid screening...