DLX5

Summary

Gene Symbol: DLX5
Description: distal-less homeobox 5
Alias: SHFM1D, homeobox protein DLX-5, distal-less homeo box 5, split hand/foot malformation type 1 with sensorineural hearing loss
Species: human
Products:     DLX5

Top Publications

  1. Kato T, Sato N, Takano A, Miyamoto M, Nishimura H, Tsuchiya E, et al. Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients. Clin Cancer Res. 2008;14:2363-70 pubmed publisher
    ..b>DLX5 gene, a member of the human distal-less homeobox transcriptional factor family that is expressed during early ..
  2. Tan Y, Timakhov R, Rao M, Altomare D, Xu J, Liu Z, et al. A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice. Cancer Res. 2008;68:1296-302 pubmed publisher
    ..The proximal breakpoint maps to a region near a locus comprising the linked homeobox/transcription factor genes Dlx5 and Dlx6...
  3. Tackels Horne D, Toburen A, Sangiorgi E, Gurrieri F, de Mollerat X, Fischetto R, et al. Split hand/split foot malformation with hearing loss: first report of families linked to the SHFM1 locus in 7q21. Clin Genet. 2001;59:28-36 pubmed
    ..37 at theta = 0.0 for locus D7S527) at 80% penetrance. Efforts to identify the responsible gene have not yet been successful. ..
  4. Shamseldin H, Faden M, Alashram W, Alkuraya F. Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation. J Med Genet. 2012;49:16-20 pubmed publisher
    ..7q21.3 (SHFM1) is one of six loci described to date, and although DLX5 and DLX6 are compelling candidates in that locus, no intragenic mutations have been described in either of these ..
  5. Kouwenhoven E, van Heeringen S, Tena J, Oti M, Dutilh B, Alonso M, et al. Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet. 2010;6:e1001065 pubmed publisher
    ..enhancer element in the SHFM1 locus on chromosome 7q and that this element controls expression of DLX6 and possibly DLX5, both of which are important for limb development...
  6. Simeone A, Acampora D, Pannese M, D ESPOSITO M, Stornaiuolo A, Gulisano M, et al. Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994;91:2250-4 pubmed
    ..We cloned and studied the expression of two members of this family, which we named Dlx5 and Dlx6, in human and mouse...
  7. Charbogne P, Gardon O, Martín García E, Keyworth H, Matsui A, Mechling A, et al. Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food. Biol Psychiatry. 2017;81:778-788 pubmed publisher
    ..We used Dlx5/6-mediated recombination to create conditional Oprm1 mice in gamma-aminobutyric acidergic forebrain neurons...
  8. Roellig D, Bronner M. The epigenetic modifier DNMT3A is necessary for proper otic placode formation. Dev Biol. 2016;411:294-300 pubmed publisher
    ..Whereas neural plate border and non-neural ectoderm markers Erni, Dlx5, Msx1 and Six1 are unaltered, DNMT3A loss of function leads to early reduction in the expression of the key otic ..
  9. Son H, Kim E, Jang W. Curcumin induces osteoblast differentiation through mild-endoplasmic reticulum stress-mediated such as BMP2 on osteoblast cells. Life Sci. 2018;193:34-39 pubmed publisher
    ..Curcumin increased the expression of genes such as distal-less homeobox 5 (Dlx5), runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OC), which subsequently induced osteoblast ..
  10. Gao G, Schilling A, Hubbell K, Yonezawa T, Truong D, Hong Y, et al. Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA. Biotechnol Lett. 2015;37:2349-55 pubmed publisher
    ..and chondrogenic differentiation as determined by specific gene and protein expression analysis (RUNX2, SP7, DLX5, ALPL, Col1A1, IBSP, BGLAP, SPP1, Col10A1, MMP13, SOX9, Col2A1, ACAN) was improved by PEG-GelMA in comparison to ..

Detail Information

Publications85

  1. Kato T, Sato N, Takano A, Miyamoto M, Nishimura H, Tsuchiya E, et al. Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients. Clin Cancer Res. 2008;14:2363-70 pubmed publisher
    ..b>DLX5 gene, a member of the human distal-less homeobox transcriptional factor family that is expressed during early ..
  2. Tan Y, Timakhov R, Rao M, Altomare D, Xu J, Liu Z, et al. A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice. Cancer Res. 2008;68:1296-302 pubmed publisher
    ..The proximal breakpoint maps to a region near a locus comprising the linked homeobox/transcription factor genes Dlx5 and Dlx6...
  3. Tackels Horne D, Toburen A, Sangiorgi E, Gurrieri F, de Mollerat X, Fischetto R, et al. Split hand/split foot malformation with hearing loss: first report of families linked to the SHFM1 locus in 7q21. Clin Genet. 2001;59:28-36 pubmed
    ..37 at theta = 0.0 for locus D7S527) at 80% penetrance. Efforts to identify the responsible gene have not yet been successful. ..
  4. Shamseldin H, Faden M, Alashram W, Alkuraya F. Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation. J Med Genet. 2012;49:16-20 pubmed publisher
    ..7q21.3 (SHFM1) is one of six loci described to date, and although DLX5 and DLX6 are compelling candidates in that locus, no intragenic mutations have been described in either of these ..
  5. Kouwenhoven E, van Heeringen S, Tena J, Oti M, Dutilh B, Alonso M, et al. Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genet. 2010;6:e1001065 pubmed publisher
    ..enhancer element in the SHFM1 locus on chromosome 7q and that this element controls expression of DLX6 and possibly DLX5, both of which are important for limb development...
  6. Simeone A, Acampora D, Pannese M, D ESPOSITO M, Stornaiuolo A, Gulisano M, et al. Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci U S A. 1994;91:2250-4 pubmed
    ..We cloned and studied the expression of two members of this family, which we named Dlx5 and Dlx6, in human and mouse...
  7. Charbogne P, Gardon O, Martín García E, Keyworth H, Matsui A, Mechling A, et al. Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food. Biol Psychiatry. 2017;81:778-788 pubmed publisher
    ..We used Dlx5/6-mediated recombination to create conditional Oprm1 mice in gamma-aminobutyric acidergic forebrain neurons...
  8. Roellig D, Bronner M. The epigenetic modifier DNMT3A is necessary for proper otic placode formation. Dev Biol. 2016;411:294-300 pubmed publisher
    ..Whereas neural plate border and non-neural ectoderm markers Erni, Dlx5, Msx1 and Six1 are unaltered, DNMT3A loss of function leads to early reduction in the expression of the key otic ..
  9. Son H, Kim E, Jang W. Curcumin induces osteoblast differentiation through mild-endoplasmic reticulum stress-mediated such as BMP2 on osteoblast cells. Life Sci. 2018;193:34-39 pubmed publisher
    ..Curcumin increased the expression of genes such as distal-less homeobox 5 (Dlx5), runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OC), which subsequently induced osteoblast ..
  10. Gao G, Schilling A, Hubbell K, Yonezawa T, Truong D, Hong Y, et al. Improved properties of bone and cartilage tissue from 3D inkjet-bioprinted human mesenchymal stem cells by simultaneous deposition and photocrosslinking in PEG-GelMA. Biotechnol Lett. 2015;37:2349-55 pubmed publisher
    ..and chondrogenic differentiation as determined by specific gene and protein expression analysis (RUNX2, SP7, DLX5, ALPL, Col1A1, IBSP, BGLAP, SPP1, Col10A1, MMP13, SOX9, Col2A1, ACAN) was improved by PEG-GelMA in comparison to ..
  11. Tan Y, Sementino E, Xu J, Pei J, Liu Z, Ito T, et al. The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling. Oncotarget. 2017;8:14941-14956 pubmed publisher
    ..to T-lymphomagenesis, we investigated a transgenic mouse model with thymocyte-specific overexpression of the Dlx5 homeobox gene. We demonstrate for the first time that Dlx5 induces T-cell lymphomas with high penetrance...
  12. Hartmann J, Dedic N, Pöhlmann M, Häusl A, Karst H, Engelhardt C, et al. Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor. Mol Psychiatry. 2017;22:466-475 pubmed publisher
    ..specifically in forebrain glutamatergic or GABAergic neurons by breeding GRflox/flox mice to Nex-Cre or Dlx5/6-Cre mice, respectively...
  13. Wei Q, Zhang J, Hong G, Chen Z, Deng W, He W, et al. Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ER?-Wnt/?-catenin signaling pathway. Biomed Pharmacother. 2016;84:931-939 pubmed publisher
    ..Additionally, icariin (0.1?M) significantly up-regulated the expression of osteogenic genes (Runx2, osteopotin, DLX5, osteocalcin, collagen type I, and ER?) and Wnt signal members (?-catenin, Lef1, TCF7, c-jun, c-myc, and cyclin D)...
  14. Laxman N, Mallmin H, Nilsson O, Kindmark A. miR-203 and miR-320 Regulate Bone Morphogenetic Protein-2-Induced Osteoblast Differentiation by Targeting Distal-Less Homeobox 5 (Dlx5). Genes (Basel). 2016;8: pubmed publisher
    ..We identified Dlx5 as potential common target by prediction algorithms and confirmed this by knock-down and over expression of the ..
  15. Poon C, Li R, Seto S, Kong S, Ho H, Hoi M, et al. In vitro vitamin K(2) and 1α,25-dihydroxyvitamin D(3) combination enhances osteoblasts anabolism of diabetic mice. Eur J Pharmacol. 2015;767:30-40 pubmed publisher
    ..plus a reduced expression of bone anabolic markers and bone formation transcription factors (osteocalcin, Runx2, Dlx5, ATF4 and OSX) were consistently detected in osteoblasts of db/db mice compared to lean mice...
  16. Zeng L, Zhao N, Han D, Liu H, Liu Y, Wang Y, et al. DLX3 mutation negatively regulates odontogenic differentiation of human dental pulp cells. Arch Oral Biol. 2017;77:12-17 pubmed publisher
    ..Odontogenic markers, including DMP-1, DSPP, Nes, ALP, and DLX5, were analyzed using real-time polymerase chain reaction (qPCR)...
  17. Wei Q, He M, Chen M, Chen Z, Yang F, Wang H, et al. Icariin stimulates osteogenic differentiation of rat bone marrow stromal stem cells by increasing TAZ expression. Biomed Pharmacother. 2017;91:581-589 pubmed publisher
    ..Icariin (0.1μM) upregulated TAZ, Runx2, β-catenin, Osteopotin, and Dlx5 expression mainly at the early stage of osteogenic differentiation, and increased osteocalcin expression at the ..
  18. Parrilla M, Chang I, Degl Innocenti A, Omura M. Expression of homeobox genes in the mouse olfactory epithelium. J Comp Neurol. 2016;524:2713-39 pubmed publisher
    ..We found that seven of them (Dlx3, Dlx5, Dlx6, Msx1, Meis1, Isl1, and Pitx1) are zonally expressed...
  19. Wein M, Fretwurst T, Nahles S, Duttenhoefer F, Tomakidi P, Steinberg T, et al. Pilot investigation of the molecular discrimination of human osteoblasts from different bone entities. J Craniomaxillofac Surg. 2015;43:1487-93 pubmed publisher
    ..Gene expression of seven genes (BMP1, CSF-1, TGFBR1, ICAM1, VCAM1, SPP1 and DLX5) was significantly higher in iHOB than in aHOB samples...
  20. Puelles L, Morales Delgado N, Merchán P, Castro Robles B, Martínez de la Torre M, Díaz C, et al. Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area. Brain Struct Funct. 2016;221:3027-65 pubmed publisher
    ..5 onward, comparing their topography with the expression patterns of the genes Dlx5, Gbx2, Lhx7-8, Nkx2.1, Nkx5.1 (Hmx3), and Shh, which variously label parts of the subpallium...
  21. Song I, Jeong B, Choi Y, Chung Y, Kim N. GATA4 negatively regulates bone sialoprotein expression in osteoblasts. BMB Rep. 2016;49:343-8 pubmed
    GATA4 has been reported to act as a negative regulator in osteoblast differentiation by inhibiting the Dlx5 transactivation of Runx2 via the attenuation of the binding ability of Dlx5 to the Runx2 promoter region...
  22. Komori T. Roles of Runx2 in Skeletal Development. Adv Exp Med Biol. 2017;962:83-93 pubmed publisher
    ..This enhancer is activated by an enhanceosome composed of Dlx5/6, Mef2, Tcf7, Ctnnb1, Sox5/6, Smad1, and Sp7...
  23. Novakovic B, Fournier T, Harris L, James J, Roberts C, Yong H, et al. Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation. Sci Rep. 2017;7:4523 pubmed publisher
    ..Three genes (TLX1, HOXA10 and DLX5) showed inverse gains of methylation with decreasing mRNA expression throughout pregnancy, supporting a role for ..
  24. Rasmussen M, Kreiborg S, Jensen P, Bak M, Mang Y, Lodahl M, et al. Phenotypic subregions within the split-hand/foot malformation 1 locus. Hum Genet. 2016;135:345-57 pubmed publisher
    Split-hand/foot malformation 1 (SHFM1) is caused by chromosomal aberrations involving the region 7q21.3, DLX5 mutation, and dysregulation of DLX5/DLX6 expression by long-range position effects...
  25. Zhao X, Deng P, Feng J, Wang Z, Xiang Z, Han X, et al. Cysteine Dioxygenase Type 1 Inhibits Osteogenesis by Regulating Wnt Signaling in Primary Mouse Bone Marrow Stromal Cells. Sci Rep. 2016;6:19296 pubmed publisher
    ..Wnt signaling and restricted the Wnt3a induced expression of osteogenic transcriptional factors, such as Runx2 and Dlx5. Collectively, our findings indicate Cdo1 suppresses osteogenic differentiation of BMSCs, through a potential ..
  26. Heo J, Choi Y, Kim H, Kim H. Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med. 2016;37:115-25 pubmed publisher
    ..differentiation stage-related genes [B4GALNT1 (GM2/GS2 synthase), inhibin, beta A (INHBA), distal-less homeobox 5 (DLX5), runt-related transcription factor 2 (RUNX2), proliferator‑activated receptor gamma (PPARG), CCAAT/enhancer-..
  27. Ramos Zaldívar H, Martínez Irías D, Espinoza Moreno N, Napky Rajo J, Bueso Aguilar T, Reyes Perdomo K, et al. A novel description of a syndrome consisting of 7q21.3 deletion including DYNC1I1 with preserved DLX5/6 without ectrodactyly: a case report. J Med Case Rep. 2016;10:156 pubmed publisher
    Chromosomal region 7q21.3 comprises approximately 5.2 mega base pairs that include genes DLX5/6, SHFM1, and DYNC1I1 associated with split hand/split foot malformation 1...
  28. Chao C, Li F, Tan Z, Zhang W, Yang Y, Luo C. miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1. Exp Cell Res. 2018;362:293-301 pubmed publisher
    ..factor-2 (Runx2), Osterix (OSX), alkaline phosphatase (ALP), osteocalcin (OCN), and distal-less homeobox 5 (DLX5) osteogenic gene expressions...
  29. Son H, Kim K, Kim E, Jang W. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018;8:2134 pubmed publisher
    ..such as Runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP), and Distal-less homeobox 5 (Dlx5)...
  30. Vincentz J, Casasnovas J, Barnes R, Que J, Clouthier D, Wang J, et al. Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap. Proc Natl Acad Sci U S A. 2016;113:7563-8 pubmed publisher
    ..Furthermore, the homeodomain proteins distal-less homeobox 5 (DLX5) and DLX6 reciprocally inhibit BMP/H2-mediated H1 enhancer regulation...
  31. Green B, Kappil M, Lambertini L, Armstrong D, Guerin D, Sharp A, et al. Expression of imprinted genes in placenta is associated with infant neurobehavioral development. Epigenetics. 2015;10:834-41 pubmed publisher
    ..Data reduction identified 10 genes (DLX5, DHCR24, VTRNA2-1, PHLDA2, NPAP1, FAM50B, GNAS-AS1, PAX8-AS1, SHANK2, and COPG2IT1) whose expression could ..
  32. Masuda Y, Sasaki A, Shibuya H, Ueno N, Ikeda K, Watanabe K. Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. J Biol Chem. 2001;276:5331-8 pubmed
    b>Dlx5, a member of the Dlx family of homeodomain proteins, plays a critical role in bone development and fracture healing...
  33. Hojo H, Ohba S, He X, Lai L, McMahon A. Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification. Dev Cell. 2016;37:238-53 pubmed publisher
    ..acid differences in the Sp7 zinc finger domain reduce Sp7's affinity for the Sp family consensus GC-box target; Dlx5 binding maps to this domain of Sp7...
  34. Ohta S, Wang B, Mansour S, Schoenwolf G. BMP regulates regional gene expression in the dorsal otocyst through canonical and non-canonical intracellular pathways. Development. 2016;143:2228-37 pubmed publisher
    ..signaling pathway regulators to developing chick otocysts, we show that BMP signaling regulates the expression of Dlx5 and Hmx3, both of which encode transcription factors essential for vestibular formation...
  35. Nakashima N, Yamagata T, Mori M, Kuwajima M, Suwa K, Momoi M. Expression analysis and mutation detection of DLX5 and DLX6 in autism. Brain Dev. 2010;32:98-104 pubmed publisher
    ..This region contains an imprinting region with MECP2-binding sites, and DLX5 is reported to be modulated by MECP2. DLX5 and adjacent DLX6 are homeobox genes working in neurogenesis...
  36. Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. J Biol Chem. 2002;277:22541-6 pubmed
    Msx2 and Dlx5 are homeodomain proteins that play an important role in osteoblast differentiation and whose expression is induced by bone morphogenetic proteins...
  37. Yu Z, Seya K, Daitoku K, Motomura S, Fukuda I, Furukawa K. Tumor necrosis factor-? accelerates the calcification of human aortic valve interstitial cells obtained from patients with calcific aortic valve stenosis via the BMP2-Dlx5 pathway. J Pharmacol Exp Ther. 2011;337:16-23 pubmed publisher
    ..gene expression of calcigenic markers, ALP, bone morphogenetic protein 2 (BMP2), and distal-less homeobox 5 (Dlx5) were significantly increased after 6 days of TNF-? treatment in the CAS group but not the control group...
  38. Barone A, Toti P, Funel N, Campani D, Covani U. Expression of SP7, RUNX1, DLX5, and CTNNB1 in human mesenchymal stem cells cultured on xenogeneic bone substitute as compared with machined titanium. Implant Dent. 2014;23:407-15 pubmed publisher
    ..RNA quantification for genes DLX5, CTNNB1, RUNX1, and SP7 was assessed by quantitative real-time polymerase chain reaction...
  39. Zadora J, Singh M, Herse F, Przybyl L, Haase N, Golic M, et al. Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker. Circulation. 2017;136:1824-1839 pubmed publisher
    ..disturbed placental imprinting in preeclampsia and revealed potential candidates, including GATA3 and DLX5, with poorly explored imprinted status and no prior association with preeclampsia...
  40. Lango Allen H, Caswell R, Xie W, Xu X, Wragg C, Turnpenny P, et al. Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in humans. J Med Genet. 2014;51:264-7 pubmed publisher
    ..3. This separates the DYNC1I1 exons recently identified as limb enhancers in mouse studies from their target genes, DLX5 and DLX6...
  41. Sugii H, Grimaldi A, Li J, Parada C, Vu Ho T, Feng J, et al. The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development. Development. 2017;144:4037-4045 pubmed publisher
    ..However, the functional significance of Dlx5 in patterning the oropharyngeal region has remained unknown...
  42. Hyung J, Ahn C, Je J. Blue mussel (Mytilus edulis) protein hydrolysate promotes mouse mesenchymal stem cell differentiation into osteoblasts through up-regulation of bone morphogenetic protein. Food Chem. 2018;242:156-161 pubmed publisher
    ..as bone morphogenetic protein-2 (BMP-2), and downstream signal and transcription factors, including p-Smad1/5/8, Dlx5, runt-related transcription factor 2 (Runx2), and osterix...
  43. Morsczeck C. Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro. Calcif Tissue Int. 2006;78:98-102 pubmed
    ..These real-time PCR results display molecular mechanisms in dental follicle precursor cells during osteogenic differentiation that are different from those in bone marrow-derived mesenchymal stem cells. ..
  44. Quach A, MacKenzie R, Bendall A. Measuring inputs to a common function: The case of Dlx5 and Dlx6. Biochem Biophys Res Commun. 2016;478:371-377 pubmed publisher
    Physically linked Dlx5 and Dlx6 paralogs are co-expressed in vertebrates and various combinations of null alleles in mice demonstrate not only functional redundancy between the paralogous factors but a similar quantitative contribution to ..
  45. Wang Y, Feng Q, Ji C, Liu X, Li L, Luo J. RUNX3 plays an important role in mediating the BMP9-induced osteogenic differentiation of mesenchymal stem cells. Int J Mol Med. 2017;40:1991-1999 pubmed publisher
    ..of osteogenic pivotal transcription factors [inhibitor of differentiation (Id)3, distal-less homeobox 5 (DLX5) and RUNX2)] was further increased by the overexpression of RUNX3; however, it was reduced by the knockdown of ..
  46. Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res. 2006;34:1735-44 pubmed
    ..The HMG domain thus not only possesses DNA-binding and DNA-bending but also protein-interacting ability which may be equally important for the architectural function of Sox proteins on their target gene promoters. ..
  47. Newberry E, Latifi T, Towler D. The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter. Biochemistry. 1999;38:10678-90 pubmed
    ..Acting as a scaffold protein, MINT potentially exerts both positive and negative regulatory actions by organizing transcriptional complexes in the nuclear matrix. ..
  48. Scherer S, Poorkaj P, Massa H, Soder S, Allen T, Nunes M, et al. Physical mapping of the split hand/split foot locus on chromosome 7 and implication in syndromic ectrodactyly. Hum Mol Genet. 1994;3:1345-54 pubmed
    ..Finally, we have mapped DLX5, a member of the Distal-less homeobox gene family, to the SHFD1 critical interval.
  49. Jacobs D, Hansen J, Fu A, Stevens R, Tjonneland A, Vogel U, et al. Methylation alterations at imprinted genes detected among long-term shiftworkers. Environ Mol Mutagen. 2013;54:141-6 pubmed publisher
    ..The strongest evidence for altered methylation patterns in shiftworkers was observed for DLX5, IGF2AS, and TP73 based on the magnitude of methylation change and consistency in the direction of change across ..
  50. Sun C, Zhang L, Feng X, Zhao Z. [Changes in the expression of Dlx5, Msx2, and Dlx5/Msx2 in hPDLSCs loaded with cyclic tensile stress]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2011;42:823-6 pubmed
    To investigate the changes in the expression of Dlx5 and Msx2 in human periodontal ligament stem cells (hPDLSCs) loaded with cyclic tensile stress. hPDLSCs were subjected to cyclic tensile stress (0...
  51. Schule B, Li H, Fisch Kohl C, Purmann C, Francke U. DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency. Am J Hum Genet. 2007;81:492-506 pubmed
    ..Recent literature claimed that the developmental homeobox gene DLX5 is imprinted and that its imprinting status is modulated by MeCP2, leading to biallelic expression in Rett syndrome ..
  52. Velinov M, Ahmad A, Brown Kipphut B, Shafiq M, Blau J, Cooma R, et al. A 0.7?Mb de novo duplication at 7q21.3 including the genes DLX5 and DLX6 in a patient with split-hand/split-foot malformation. Am J Med Genet A. 2012;158A:3201-6 pubmed publisher
    ..3 region harboring DSS1, DLX5, and DLX6...
  53. von Schoubye N, Frederiksen K, Kristiansen U, Petersen A, Dalby N, Grunnet M, et al. The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/- mice. Neurosci Lett. 2018;662:29-35 pubmed publisher
    ..We then tested if Lu AE98134 could normalize the altered firing properties of FSINs in Dlx5/6+/- mutant mice...
  54. Willis D, Loewy A, Charlton Kachigian N, Shao J, Ornitz D, Towler D. Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. J Biol Chem. 2002;277:37280-91 pubmed
    ..In toto, these data indicate that a novel Ku antigen complex assembles on the OC promoter, functioning in concert with Msx2 and Runx2 to regulate OC gene expression. ..
  55. Okita C, Meguro M, Hoshiya H, Haruta M, Sakamoto Y, Oshimura M. A new imprinted cluster on the human chromosome 7q21-q31, identified by human-mouse monochromosomal hybrids. Genomics. 2003;81:556-9 pubmed
    ..One of the 6 candidate genes/transcripts, i.e., DLX5 was confirmed to be imprinted in normal human lymphoblasts and brain tissues by a polymorphic analysis...
  56. Bapat S, Galande S. Association by guilt: identification of DLX5 as a target for MeCP2 provides a molecular link between genomic imprinting and Rett syndrome. Bioessays. 2005;27:676-80 pubmed
    ..and formation of a higher-order chromatin loop structure specifically associated with silent chromatin at the Dlx5-Dlx6 locus in normal cells, and its absence thereof in RTT patients...
  57. Okada E, Nakata H, Yamamoto M, Kasugai S, Kuroda S. Indirect osteoblast differentiation by liposomal clodronate. J Cell Mol Med. 2017;: pubmed publisher
    ..marrow-derived mesenchymal stromal cell culture enhanced alkaline phosphatase activity and mRNA levels of Runx2 and Dlx5. In addition, conditioned medium from liposomal clodronate also stimulated osteogenic characteristics similar to ..
  58. Tan Y, Cheung M, Pei J, Menges C, Godwin A, Testa J. Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling. Cancer Res. 2010;70:9197-206 pubmed publisher
    ..We had previously found that Dlx5 is overexpressed in an Akt2 transgenic model of T-cell lymphoma...
  59. Itaba Matsumoto N, Maegawa S, Yamagata H, Kondo I, Oshimura M, Nanba E. Imprinting status of paternally imprinted DLX5 gene in Japanese patients with Rett syndrome. Brain Dev. 2007;29:491-5 pubmed
    ..Paternally imprinted distal-less homeobox gene 5 (DLX5), that has an important role for the development of gamma-aminobutyric acid (GABA)-ergic neurons, was identified as ..
  60. Wang X, Xin Q, Li L, Li J, Zhang C, Qiu R, et al. Exome sequencing reveals a heterozygous DLX5 mutation in a Chinese family with autosomal-dominant split-hand/foot malformation. Eur J Hum Genet. 2014;22:1105-10 pubmed publisher
    ..558G>T (p.(Gln186His)), in distal-less homeobox 5 (DLX5)...
  61. Ka M, Moffat J, Kim W. MACF1 Controls Migration and Positioning of Cortical GABAergic Interneurons in Mice. Cereb Cortex. 2017;27:5525-5538 pubmed publisher
    ..interneurons, we conditionally deleted the MACF1 gene in mouse interneuron progenitors and their progeny using Dlx5/6-Cre-IRES-EGFP and Nkx2.1-Cre drivers...
  62. Rattanasopha S, Tongkobpetch S, Srichomthong C, Kitidumrongsook P, Suphapeetiporn K, Shotelersuk V. Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I. J Med Genet. 2014;51:817-23 pubmed publisher
    ..3. While double knockout of Dlx5 and Dlx6 resulted in limb defects in mice, the majority of patients with SHFM1 had only heterozygous chromosomal ..
  63. Waclaw R, Ehrman L, Merchan Sala P, Kohli V, Nardini D, Campbell K. Foxo1 is a downstream effector of Isl1 in direct pathway striatal projection neuron development within the embryonic mouse telencephalon. Mol Cell Neurosci. 2017;80:44-51 pubmed publisher
    ..1. Conditional knockout of Foxo1 using Dlx5/6-CIE mice results in reduced expression of the SPN marker Darpp-32, as well as in the direct pathway SPN markers ..
  64. Yu G, Zerucha T, Ekker M, Rubenstein J. Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins. Brain Res Dev Brain Res. 2001;130:217-30 pubmed
    ..We provide evidence that GRIP1b can function as a transcriptional co-activator of DLX2 and DLX5. Glutamate receptors inhibit this co-activation...
  65. Zhang H, Hu G, Wang H, Sciavolino P, Iler N, Shen M, et al. Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism. Mol Cell Biol. 1997;17:2920-32 pubmed
    ..Finally, we show that the expression patterns of representative Msx and Dlx genes (Msx1, Msx2, Dlx2, and Dlx5) overlap in mouse embryogenesis during limb bud and craniofacial development, consistent with the potential for ..
  66. Vera Carbonell A, Moya Quiles M, Ballesta Martínez M, Lopez Gonzalez V, Bafalliu J, Guillen Navarro E, et al. Rapp-Hodgkin syndrome and SHFM1 patients: delineating the p63-Dlx5/Dlx6 pathway. Gene. 2012;497:292-7 pubmed publisher
    ..p63 is directly associated with a cis-regulatory element on chromosome 7q21 that controls the expression of DLX5 and DLX6 genes which are involved in craniofacial abnormalities and ectrodactyly or split hand/foot malformation (..
  67. Kim D, Kim E, Jang W. Piperine induces osteoblast differentiation through AMPK-dependent Runx2 expression. Biochem Biophys Res Commun. 2018;495:1497-1502 pubmed publisher
    ..Piperine-induced expression of the osteogenic genes such as distal-less homeobox 5 (Dlx5), inhibitor of DNA binding-1 (Id1), and runt-related transcription factor 2 (Runx2) was investigated using RT-PCR...
  68. Ju H, Lee S, Lee J, Ghil S. Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1. Biochem Biophys Res Commun. 2017;489:109-115 pubmed publisher
    ..cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and distal-less Homeobox 5 (Dlx5) and Runx2 promoter activation...
  69. Proudfoot A, Axelrod H, Geralt M, Fletterick R, Yumoto F, Deacon A, et al. Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. J Mol Biol. 2016;428:1130-1141 pubmed publisher
    The Dlx5 homeodomain is a transcription factor related to the Drosophila distal-less gene that is associated with breast and lung cancer, lymphoma, Rett syndrome and osteoporosis in humans...
  70. Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, et al. Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017;292:15814-15825 pubmed publisher
    ..is manifested within the calvarial primordia, including Bmp2 and its downstream genes Msx1/2 and Dlx5 By contrast, we find that Gli1, the Hedgehog activity readout gene, is excessively activated in ..
  71. Park S, Lee J, Kang M, Moon Y, Wang S, Kim K, et al. Potential of l-thyroxine to differentiate osteoblast-like cells via Angiopoietin1. Biochem Biophys Res Commun. 2016;478:1409-15 pubmed publisher
    ..such as type I collagen (COL1A1), osteocalcin (OC), bone sialoprotein (BSP), distal-less homeobox 5 (Dlx5), Runt-related transcription factor 2 (Runx2), osterix (OSX), and ALP, was tested by Western blotting analysis...
  72. Karsli Ceppioğlu S, Dagdemir A, Judes G, Lebert A, Penault Llorca F, Bignon Y, et al. The Epigenetic Landscape of Promoter Genome-wide Analysis in Breast Cancer. Sci Rep. 2017;7:6597 pubmed publisher
    ..The central genes of the network (RUNX1, PAX3, GATA4 and DLX5) were subjected for epigenetically dysregulation in association with different breast cancer subtypes...
  73. Morini M, Astigiano S, Gitton Y, Emionite L, Mirisola V, Levi G, et al. Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231. BMC Cancer. 2010;10:649 pubmed publisher
    ..Expression of DLX2, DLX5 and DLX6 was assessed in cultured cells, either treated or not with ET1, tumors and metastases by RT-PCR...
  74. Yang D, Okamura H, Qiu L. Upregulated osterix expression elicited by Runx2 and Dlx5 is required for the accelerated osteoblast differentiation in PP2A C?-knockdown cells. Cell Biol Int. 2017;: pubmed publisher
    ..is controlled by main bone specific transcription factors including Osterix, distal-less homeobox 5 (Dlx5), and Runt-related transcription factor 2 (Runx2)...
  75. Colasante G, Lignani G, Rubio A, Medrihan L, Yekhlef L, Sessa A, et al. Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming. Cell Stem Cell. 2015;17:719-34 pubmed publisher
    ..We identified five factors (Foxg1, Sox2, Ascl1, Dlx5, and Lhx6) that convert mouse fibroblasts into induced GABAergic INs (iGABA-INs) possessing molecular signatures of ..
  76. Klar A. Split hand/foot malformation genetics supports the chromosome 7 copy segregation mechanism for human limb development. Philos Trans R Soc Lond B Biol Sci. 2016;371: pubmed
    ..Mutations of the DLX5 (distal-less) transcription factor-encoding gene in chromosome 7 cause SHFM through haploinsufficiency, but the ..
  77. Kim K, Jang W. Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation. Bioorg Med Chem Lett. 2017;27:4789-4793 pubmed publisher
    ..the expression of key osteogenic genes in the early stage of differentiation, including distal-less homeobox 5 (Dlx5), DNA-binding protein inhibitor (Id1) and Runt-related transcription factor 2 (Runx2)...
  78. Xu J, Testa J. DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC. J Biol Chem. 2009;284:20593-601 pubmed publisher
    ..Recently, DLX5 was reported to act as an oncogene in lymphomas and lung cancers, although the mechanism is not known...
  79. Sowinska Seidler A, Badura Stronka M, Latos Bielenska A, Stronka M, Jamsheer A. Heterozygous DLX5 nonsense mutation associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated families. Birth Defects Res A Clin Mol Teratol. 2014;100:764-71 pubmed publisher
    ..reduced penetrance, although recessive inheritance has been described for a single family carrying a homozygous DLX5 missense variant...
  80. Fakhouri W, Metwalli K, Naji A, Bakhiet S, Quispe Salcedo A, Nitschke L, et al. Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development. Sci Rep. 2017;7:7129 pubmed publisher
    ..of Endothelin1 (EDN1) in mandible and transcription factors that are critical for mandibular patterning including DLX5, DLX6 and HAND2, were also reduced in mesenchymal cells...
  81. Eisenstat D, Liu J, Mione M, Zhong W, Yu G, Anderson S, et al. DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation. J Comp Neurol. 1999;414:217-37 pubmed
    ..In the basal telencephalon, these DLX-positive cells differentiate into projection neurons of the striatum and pallidum as well as interneurons, some of which migrate to the cerebral cortex and the olfactory bulb. ..
  82. Alghanim H, Antunes J, Silva D, Alho C, Balamurugan K, McCord B. Detection and evaluation of DNA methylation markers found at SCGN and KLF14 loci to estimate human age. Forensic Sci Int Genet. 2017;31:81-88 pubmed publisher
    ..A total number of 27 CpG sites at three genetic loci, SCGN, DLX5 and KLF14, were examined to evaluate the correlation of their methylation status with age...
  83. Kusuyama J, Kamisono A, ChangHwan S, Amir M, Bandow K, Eiraku N, et al. Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities. J Cell Physiol. 2017;: pubmed publisher
    ..as the expression levels of osteocalcin, runt-related transcription factor 2 (Runx2), and distal-less homeobox 5 (Dlx5) mRNAs...
  84. Artigas N, Gámez B, Cubillos Rojas M, Sánchez de Diego C, Valer J, Pons G, et al. p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation. Cell Death Differ. 2017;24:2022-2031 pubmed publisher
    Osteoblast differentiation is achieved by activating a transcriptional network in which Dlx5, Runx2 and Osx/SP7 have fundamental roles...