DLGAP1

Summary

Gene Symbol: DLGAP1
Description: discs, large (Drosophila) homolog-associated protein 1
Alias: DAP-1, DAP-1-ALPHA, DAP-1-BETA, GKAP, SAPAP1, hGKAP, PSD-95/SAP90 binding protein 1, SAP90/PSD-95-associated protein 1, disks large-associated protein 1, guanylate kinase-associated protein
Species: human

Top Publications

  1. ncbi BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein
    M Deguchi
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 273:26269-72. 1998
  2. ncbi Synapse formation by hippocampal neurons from agrin-deficient mice
    A S Serpinskaya
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, 61801, USA
    Dev Biol 205:65-78. 1999
  3. ncbi A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate
    M J Muñoz-Alonso
    CNRS UPR 1524, 9, rue Jules Hetzel, 92190 Meudon, INSERM U505, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 275:32406-12. 2000
  4. ncbi Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    BMC Evol Biol 10:351. 2010
  5. ncbi Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 20:4524-34. 2000
  6. ncbi GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Cell Biol 136:669-78. 1997
  7. ncbi Intramolecular interactions regulate SAP97 binding to GKAP
    H Wu
    University of Alabama at Birmingham, Department of Neurobiology, 1719 Sixth Avenue South CIRC 589, Birmingham, AL 35294 0021, USA
    EMBO J 19:5740-51. 2000
  8. ncbi DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95
    K Satoh
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Genes Cells 2:415-24. 1997
  9. ncbi Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model
    Alexander A Firsov
    Department of Pharmacokinetics and Pharmacodynamics, Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 Bolshaya Pirogovskaya Street, Moscow, 119021 Russia
    J Antimicrob Chemother 58:1185-92. 2006
  10. ncbi Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system
    M Raab
    Department of Anatomy I, University of Erlangen Nuremberg, Krankenhausstrasse 9, 91054 Erlangen, Germany
    Neuroscience 171:421-33. 2010

Research Grants

  1. Glutamate Receptor Trafficking in Visual Development
    Martha Constantine Paton; Fiscal Year: 2005
  2. Vanilloid Receptor VR1 in Osteoarthritis
    Juli Valtschanoff; Fiscal Year: 2009
  3. Postsynaptic Protein Trafficking and Synapse Remodeling
    Sang H Lee; Fiscal Year: 2010
  4. Postsynaptic Protein Trafficking and Synapse Remodeling
    Sang H Lee; Fiscal Year: 2011
  5. NITRIC OXIDE SIGNALING MECHANISMS IN VASCULAR CELLS
    Michael Mendelsohn; Fiscal Year: 2004
  6. Targeting mechanisms of cGMP dependent protein kinases by peptide arrays and crys
    CHOEL WOONG KIM; Fiscal Year: 2010
  7. Modulation and Targeting of Kainate Receptors
    John Marshall; Fiscal Year: 2004
  8. Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior
    Guoping Feng; Fiscal Year: 2007
  9. Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior
    Guoping Feng; Fiscal Year: 2009
  10. Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior
    Guoping Feng; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications95

  1. ncbi BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein
    M Deguchi
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 273:26269-72. 1998
    ..PSD-95/SAP90 also interacts with the postsynaptic density (PSD) fraction-enriched protein, named SAPAP (also called GKAP and DAP), through the GK domain...
  2. ncbi Synapse formation by hippocampal neurons from agrin-deficient mice
    A S Serpinskaya
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, 61801, USA
    Dev Biol 205:65-78. 1999
    ..AMPA- and NMDA-type glutamate receptors, GABAA receptors, and the putative synapse-organizing proteins PSD-95, GKAP, and gephyrin formed numerous clusters at synaptic sites...
  3. ncbi A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate
    M J Muñoz-Alonso
    CNRS UPR 1524, 9, rue Jules Hetzel, 92190 Meudon, INSERM U505, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 275:32406-12. 2000
    ..We called this protein the glucokinase-associated phosphatase (GKAP)...
  4. ncbi Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    BMC Evol Biol 10:351. 2010
    ..Nevertheless, also several diseases show latitudinal clinals such as hypertension, cancer, dismetabolic conditions, schizophrenia, Parkinson's disease and many more...
  5. ncbi Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 20:4524-34. 2000
    ..demonstrate a direct interaction between the PSD-95-associated protein guanylate kinase domain-associated protein (GKAP) and dynein light chain (DLC), a light chain subunit shared by myosin-V (an actin-based motor) and cytoplasmic ..
  6. ncbi GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Cell Biol 136:669-78. 1997
    ..We now report the isolation of a novel synaptic protein, termed GKAP for guanylate kinase-associated protein, that binds directly to the GK domain of the four known members of the ..
  7. ncbi Intramolecular interactions regulate SAP97 binding to GKAP
    H Wu
    University of Alabama at Birmingham, Department of Neurobiology, 1719 Sixth Avenue South CIRC 589, Birmingham, AL 35294 0021, USA
    EMBO J 19:5740-51. 2000
    ..the molecular mechanisms that regulate the interaction of the MAGUK SAP97 with its GUK domain binding partner GKAP (GUK-associated protein). The GKAP-GUK interaction is regulated by a series of intramolecular interactions...
  8. ncbi DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95
    K Satoh
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Genes Cells 2:415-24. 1997
    ....
  9. ncbi Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model
    Alexander A Firsov
    Department of Pharmacokinetics and Pharmacodynamics, Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 Bolshaya Pirogovskaya Street, Moscow, 119021 Russia
    J Antimicrob Chemother 58:1185-92. 2006
    ....
  10. ncbi Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system
    M Raab
    Department of Anatomy I, University of Erlangen Nuremberg, Krankenhausstrasse 9, 91054 Erlangen, Germany
    Neuroscience 171:421-33. 2010
    ..protein 90/postsynaptic density protein-95-associated protein (SAPAP)/guanylate-kinase-associated protein (GKAP) interaction partners and also isolated from synaptic junctional protein preparations of rat brain...
  11. ncbi The first organic-templated vanadyl(IV) gallophosphates with ambient (51)V hyperfine structure, {V(2)Ga(2)O(14)} cluster or heterometal 12-ring channels
    Li Hsun Huang
    Department of Chemistry, National Tsing HuaUniversity, Hsinchu 30013, Taiwan
    Inorg Chem 48:11882-8. 2009
    ..6374(5) A, c = 17.8608(6) A, beta = 97.272(1) degrees , V = 2313.1(1) A(3), and Z = 4; and for 3, monoclinic, P2(1)/c, a = 9.0970(5) A, b = 16.9940(9) A, c = 9.6441(5) A, beta = 103.456(3) degrees , V = 1450.0(1) A(3), and Z = 4...
  12. ncbi Concentration-response relationships as a basis for choice of the optimal endpoints of the antimicrobial effect: daptomycin and vancomycin pharmacodynamics with staphylococci in an in vitro dynamic model
    Maria V Smirnova
    Department of Pharmacokinetics and Pharmacodynamics, Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 Bolshaya Pirogovskaya Street, Moscow 119021, Russia
    Int J Antimicrob Agents 29:165-9. 2007
    ..The better abilities of ABBC and N(min) and the inability of T(90%) and T(99%) to provide reasonable AUC/MIC relationships with DAP and VAN support earlier findings reported with fluoroquinolones...
  13. ncbi Life and death in the placenta: new peptides and genes regulating human syncytiotrophoblast and extravillous cytotrophoblast lineage formation and renewal
    D W Morrish
    Department of Medicine, University of Alberta, 362 Heritage Medical Research Center, Edmonton, Alberta, T6G 2S2, Canada
    Curr Protein Pept Sci 2:245-59. 2001
    ..Thus, the placenta is both a rich source of new growth-regulatory substances, and a model system for originating new paradigms of developmental biology...
  14. ncbi PSD93 regulates synaptic stability at neuronal cholinergic synapses
    Michael J Parker
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:378-88. 2004
    ..Furthermore, two additional components of the well characterized glutamatergic postsynaptic complex, GKAP/SAPAP (guanylate kinase domain-associated protein/synapse-associated protein-associated protein) and Shank/ProSAP ..
  15. ncbi Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities
    Janin Schütt
    Institute for Human Genetics, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    J Biol Chem 284:25479-87. 2009
    ..levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components, such as Shank1, SAPAP1-3, PSD-95, and the glutamate receptor subunits NR1 and NR2B, are associated with FMRP...
  16. ncbi Unbalanced whole arm translocation resulting in loss of 18p in dystonia
    Jamal Nasir
    Academic Neurology Unit, Section of Genetics and Informatics, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom
    Mov Disord 21:859-63. 2006
    ....
  17. ncbi Repeated variable prenatal stress alters pre- and postsynaptic gene expression in the rat frontal pole
    Anu K Kinnunen
    Novartis Pharma AG, Nervous System Research, Basel, Switzerland
    J Neurochem 86:736-48. 2003
    ....
  18. ncbi Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules
    D W Allison
    Department of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801, USA
    J Neurosci 20:4545-54. 2000
    ..The same was largely true for GKAP, a PSD-95-interacting protein...
  19. ncbi 3,4-Diaminopyridine is more effective than placebo in a randomized, double-blind, cross-over drug study in LEMS
    Shin J Oh
    Department of Neurology, University of Alabama at Birmingham, Veterans Affairs Medical Center, UAB Station, Birmingham, Alabama 35294, USA
    Muscle Nerve 40:795-800. 2009
    ..A randomized, double-blind, cross-over drug trial of 3,4-DAP showed significant efficacy over placebo in patients with LEMS. As a long-term treatment, however, not all patients preferred this drug...
  20. ncbi Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein
    Ikuko Yao
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurosci 22:5354-64. 2002
    ....
  21. ncbi Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein
    I Yao
    Takai Biotimer Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 274:27463-6. 1999
    Guanylate kinase-associated protein (GKAP)/SAP90/PSD-95-associated protein (SAPAP)/DLG-associated protein (DAP) is a protein of the postsynaptic density (PSD), and binds to the guanylate kinase domain of PSD-95/synapse-associated protein (..
  22. ncbi Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells
    Noriyuki Asaba
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Biol Chem 278:8395-400. 2003
    ..This stalk segment is not found in GKAP, a synaptic protein that interacts with the guanylate kinase-like domain, and unlike GKAP, the binding of GAKIN is ..
  23. ncbi A growing family of dual specificity phosphatases with low molecular masses
    N Aoki
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Biochem 130:133-40. 2001
    ..LMW-DSP4 exhibited the highest similarity to human YVH1 and rat GKAP, but its C-terminal region was much shorter than that of the human and rat clones...
  24. ncbi A series of vanadogermanates from 1D chain to 3D framework built by Ge-V-O clusters and transition-metal-complex bridges
    Jian Zhou
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P R China
    Chemistry 16:13253-61. 2010
    ..Magnetic measurements illustrate that both 1 and 2 have antiferromagnetic exchange interactions between metal centers, whereas 3 exhibits ferrimagnetic behavior, which is rare in polyoxovanadate complexes...
  25. ncbi Mutation and association analysis of the DAP-1 gene with schizophrenia
    Shinsuke Aoyama
    Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan
    Psychiatry Clin Neurosci 57:545-7. 2003
    ..The results do not provide evidence that the DAP-1 gene is involved in vulnerability to schizophrenia...
  26. ncbi Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 23:569-82. 1999
    ..density (PSD) proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP. A ternary complex of Shank/GKAP/PSD-95 assembles in heterologous cells and can be coimmunoprecipitated from rat ..
  27. ncbi Identification of novel cellular proteins that bind to the LC8 dynein light chain using a pepscan technique
    I Rodriguez-Crespo
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, Spain
    FEBS Lett 503:135-41. 2001
    ..consensus sequences were identified: GIQVD present in nNOS, in DNA cytosine methyl transferase and also in GKAP, where it is present twice in the protein sequence...
  28. ncbi Global profiling of protein kinase activities in cancer cells by mass spectrometry
    Luisa Beltran
    Analytical Signaling Group, Centre for Cell Signaling, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    J Proteomics 77:492-503. 2012
    ..In Global Kinase Activity Profiling (GKAP), protein kinases present in experimental cell lysates phosphorylate endogenous substrates, also present in the ..
  29. ncbi 1,12-diazaperylene and 2,11-dialkylated-1,12-diazaperylene iridium(III) complexes [Ir(C^N)2(N^N)]PF6: new supramolecular assemblies
    Stefan Kammer
    Universitat Potsdam, Institut fur Chemie, Anorganische Chemie, Potsdam, Germany
    Dalton Trans 41:10219-27. 2012
    ..Thereby, the stability agreed well with the order of the Ir-N(N^N) bond lengths...
  30. ncbi Prostaglandins as negative regulators against lipopolysaccharide, lipoteichoic acid, and peptidoglycan-induced inducible nitric oxide synthase/nitric oxide production through reactive oxygen species-dependent heme oxygenase 1 expression in macrophages
    Chih Chiang Chien
    Division of Nephrology, Chi Mei Medical Center, Tainan, Taiwan
    Shock 38:549-58. 2012
    ..Reactive oxygen species-dependent HO-1 protein expression by PGs, which inhibited LPS-, LTA-, and PGN-induced iNOS/NO production, was identified in macrophages...
  31. ncbi GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity
    Enora Moutin
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, F 34000 Montpellier, France
    J Cell Sci 125:2030-40. 2012
    ..a core protein of the glutamatergic receptor postsynaptic scaffold complex, guanylate-kinase-associated protein (GKAP) interacts with dynein light chain 2 (DLC2, also known as DYNLL2), a protein associated with molecular motors...
  32. ncbi Pattern of deposition of cell wall polysaccharides and transcript abundance of related cell wall synthesis genes during differentiation in barley endosperm
    Sarah M Wilson
    Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Victoria 3010, Australia
    Plant Physiol 159:655-70. 2012
    ....
  33. ncbi Enhancing the promiscuous phosphotriesterase activity of a thermostable lactonase (GkaP) for the efficient degradation of organophosphate pesticides
    Yu Zhang
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Appl Environ Microbiol 78:6647-55. 2012
    ..Here, a thermostable PLL from Geobacillus kaustophilus HTA426 (GkaP) was targeted for joint laboratory evolution with the aim of enhancing its catalytic efficiency against OP ..
  34. ncbi Daptomycin versus vancomycin in a methicillin-resistant Staphylococcus aureus endophthalmitis rabbit model: bactericidal effect, safety, and ocular pharmacokinetics
    Sophie Lefevre
    Institute of Bacteriology, University of Strasbourg, Strasbourg, France
    Antimicrob Agents Chemother 56:2485-92. 2012
    ..2 mg and 1 mg of daptomycin (DAP 0.2 and DAP 1 groups, respectively) with that of 1 mg of intravitreal vancomycin (VAN 1 group)...
  35. ncbi Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms
    Toshihiko Kuriu
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurosci 26:7693-706. 2006
    ..We show here that four major scaffolding molecules, PSD-95, GKAP, Shank, and PSD-Zip45, show distinct instability in total molecular content per synapse...
  36. ncbi Collagen cross linking agents: design and development of a multifunctional cross linker
    Richard S Givens
    Department of Chemistry, University of Kansas, Lawrence, KS, USA
    Photochem Photobiol 84:185-92. 2008
    ..The bonding decreased rapidly with increasingly hydrated tissue possibly due to the increased distance between the collagen fibrils and the competition of H2O for the free ketene functions...
  37. ncbi Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA
    Stefan Kindler
    Institute for Cell Biochemistry and Clinical Neurobiology, University Hospital Hamburg Eppendorf, Hamburg D 20246, Germany
    Brain Res Mol Brain Res 126:14-21. 2004
    The four members of the family of synapse-associated protein 90/postsynaptic density-95-associated proteins (SAPAP1-4) are adapter proteins of postsynaptic density (PSD)...
  38. ncbi Catalytic mechanism of l,l-diaminopimelic acid with diaminopimelate epimerase by molecular docking simulations
    L Brunetti
    Dipartimento di Scienze e Tecnologie Chimiche, Universita Politecnica delle Marche, Via Brecce Bianche, I 60131 Ancona, Italy
    J Mol Graph Model 26:1082-90. 2008
    ..All this mechanistic information could be useful for the rational design of new potential antibiotic drugs effective as inhibitors of peptidoglycan biosynthesis...
  39. ncbi Preparation and antibacterial activity of copper and cobalt complexes of 4-chloro-3-nitrobenzoate with a nitrogen donor ligand
    Ahmad Toufic Kabbani
    Natural Science Division, Lebanese American University, Beirut Lebanon
    Chem Pharm Bull (Tokyo) 55:446-50. 2007
    ..Complex [Cu(ClNBz)(o-PDA)]Cl (2) shows high antibacterial activity as indicated by its ability to inhibit the growth of Staphylococcus aureus, Enterococcus faecalis...
  40. ncbi Profiling of selenomethionine responsive genes in colon cancer by microarray analysis
    Anne Christine Goulet
    Department of Pathology, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Biol Ther 6:494-503. 2007
    ..Finally, our studies provide a practical foundation for the further development of biomarkers to monitor the efficacy of selenomethionine in clinical trials...
  41. ncbi Gtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation
    Cristina González-Estévez
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:13373-8. 2007
    ..Our findings provide insights into the complex interconnections among cell proliferation, homeostasis, and cell death in planarians and perspectives for the understanding of neoblast stem cell dynamics...
  42. ncbi Regulation of phosphorylation at the postsynaptic density during different activity states of Ca2+/calmodulin-dependent protein kinase II
    Ayse Dosemeci
    Laboratory of Neurobiology, NINDS, NIH, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 391:78-84. 2010
    ..of CaMKII-regulated sites on SAPAPs and Shanks, including three conserved serine residues near the C-termini of SAPAP1, SAPAP2, and SAPAP3...
  43. ncbi Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila
    Lark Kyun Kim
    Department of Biochemistry, National Creative Research Initiative Center for Genome Regulation, Yonsei University, Seoul, Korea
    PLoS Biol 5:e238. 2007
    ..We conclude that an inhibitory effect of AP-1 and STAT on NF-kappaB is required for properly balanced immune responses and appears to be evolutionarily conserved...
  44. ncbi Field test of in situ soil amendments at the Tar Creek National Priorities List Superfund site
    S L Brown
    Forest Resources, University of Washington, Seattle, WA 98195, USA
    J Environ Qual 36:1627-34. 2007
    ..For the yard soil, Compost+Al was the most effective treatment tested. For the tailings, BS+DAP 1% was the most effective treatment tested...
  45. ncbi Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model
    Francis W Muregi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, 1 20 1, Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    Exp Parasitol 121:376-80. 2009
    ..Drugs in a synergistic combination may exert less resistance selection pressure, thus FOA-PYR and FOA-DAP-ART warrant further evaluation with an ultimate object of possible clinical use against drug-resistant malaria...
  46. ncbi Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity
    Jean Baptiste Manneville
    UMR144 Centre National de la Recherche Scientifique Institut Curie, Paris, France
    J Cell Biol 191:585-98. 2010
    ..Dlg1 interacts with dynein via the scaffolding protein GKAP and together, Dlg1, GKAP, and dynein control microtubule dynamics and organization near the cell cortex and promote ..
  47. ncbi A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring
    Darren E Casteel
    Department of Medicine and Cancer Center, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:32684-8. 2010
    ..Our structure provides molecular details of this unique leucine/isoleucine zipper, revealing specific hydrophobic and ionic interactions that mediate dimerization and demonstrating the topology of the GKAP interaction surface.
  48. ncbi Mouse chromosome 17 candidate modifier genes for thrombosis
    Qila Sa
    Departments of Cardiovascular Medicine and Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, OH, 44195, USA
    Mamm Genome 21:337-49. 2010
    ..Seven genes, Twsg1, Zfp161, Dlgap1, Ralbp1, Myom1, Rab31, and Emilin2, of the 23 genes with single nucleotide polymorphisms (SNPs) in the mRNA-UTR ..
  49. ncbi Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain
    Jörn Saupe
    Leibniz Institut fur Molekulare Pharmakologie FMP, Robert Rossle Str 10, 13125 Berlin, Germany
    ChemMedChem 6:1411-22. 2011
    ..linked to the PSD complex via its PDZ domain that binds to the C-terminus of guanylate-kinase-associated protein (GKAP). Here, small-molecule inhibitors of Shank3 PDZ domain are developed...
  50. ncbi IFN-gamma enhances killing of methicillin-resistant Staphylococcus aureus by human monocytes more effectively than GM-CSF in the presence of daptomycin and other antibiotics
    Raymond P Smith
    Stratton VA Medical Center, 113 Holland Avenue, Albany, NY 12208, USA
    Cytokine 51:274-7. 2010
    ..Further studies to confirm these observations with IFN-gamma-activated MDM and other MRSA strains are needed to support clinical trials for difficult-to-treat MRSA infections...
  51. ncbi CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton
    Francesco Roselli
    Neuroadaptation Group, Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 6:e23097. 2011
    ..we investigated in rat frontal cortex dissociated culture the mechanisms involved in the downregulation of GKAP (SAPAP1), which links the PSD95 complex to the Shank complex and cytoskeletal structures within the PSD...
  52. ncbi Stability of disubstituted copper complexes in the gas phase analyzed by electrospray ionization mass spectrometry
    Ines Starke
    Chemisches Institut, Universitat Potsdam, Karl Liebknecht Str 24 25, D 14476 Potsdam Golm, Germany
    Rapid Commun Mass Spectrom 24:1319-26. 2010
    ..Furthermore, complexation with the ligands 2,11-dialkylated 1,12-diazaperylenes [alkyl = ethyl (dedap) and isopropyl (dipdap)] was studied in the solvents CH(3)OH and CH(3)CN...
  53. ncbi Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules
    Jinwei Zhu
    Department of Chemistry, and Institutes of Biomedical Sciences, Fudan University, Shanghai, PR China
    EMBO J 30:4986-97. 2011
    ..that the previously reported GK domain-mediated interactions of DLGs with other targets, such as GKAP/DLGAP1/SAPAP1 and SPAR, are also phosphorylation dependent...
  54. ncbi Mixed Anion (Phosphate/Oxalate) Bonding to Iron(III) Materials
    Fiona R Kizewski
    Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695 8204, and Department of Soil Science, North Carolina State University, Raleigh, North Carolina 27695 7619
    J Am Chem Soc 132:2301-8. 2010
    ..Furthermore, syntheses demonstrated the critical role of the templating amine to mediate whether or not the iron(III) is reduced by the organic acid...
  55. ncbi Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons
    Albert Y Hung
    Departments of Brain and Cognitive Sciences and Biology, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 5:e9842. 2010
    ..we identify the RING finger-containing protein TRIM3 as a specific E3 ubiquitin ligase for the PSD scaffold GKAP/SAPAP1. Present in PSD fractions from rat brain, TRIM3 stimulates ubiquitination and proteasome-dependent degradation of ..
  56. ncbi Spatial and temporal profiles of cytokinin biosynthesis and accumulation in developing caryopses of maize
    Tomaz Rijavec
    National Institute of Biology, Vecna pot 111, Ljubljana, Slovenia
    Ann Bot 107:1235-45. 2011
    ....
  57. ncbi Development of des-fatty acyl-polymyxin B decapeptide analogs with Pseudomonas aeruginosa-specific antimicrobial activity
    Naoko Katsuma
    Faculty of Pharmaceutical Sciences, Hokuriku University, Kunazawa, Japan
    Chem Pharm Bull (Tokyo) 57:332-6. 2009
    ..5 and 19.0 micromol/kg, respectively, in contrast to PMB (LD(50), 4.8 micromol/kg)...
  58. ncbi Gtdap-1 and the role of autophagy during planarian regeneration and starvation
    Cristina González-Estévez
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Autophagy 3:640-2. 2007
    ..Our data suggest that autophagy of existing cells may be essential to fuel the continued proliferation and differentiation of stem cells by providing the necessary energy and building blocks to neoblasts...
  59. ncbi Using Drosophila eye as a model system to characterize the function of mars gene in cell-cycle regulation
    Ching Po Yang
    Department of Life Science and Life Science Research Center, Tunghai University, Taichung, 407 Taiwan, Republic of China
    Exp Cell Res 307:183-93. 2005
    ..in Drosophila, which encodes a protein with a high similarity to HURP in its guanylate kinase-associated protein (GKAP) motif...
  60. ncbi The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase
    K Haraguchi
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Genes Cells 5:905-911. 2000
    ..PSD-95 also interacts with the hDLG-associated protein DAP, which is also called Synapse-associated protein 90-associated protein (SAPAP), and Guanylate kinase-associated protein (GKAP).
  61. ncbi Radiation exposure of patients and coronary arteries in the stent era: A prospective study
    D Katritsis
    Department of Cardiology, Athens Euroclinic, Athens, Greece
    Catheter Cardiovasc Interv 51:259-64. 2000
    ..Our method can be used for calculation of radiation risk to patients and radiation dose to coronary arteries by using external dosimeters. Cathet. Cardiovasc. Intervent. 51:259-264, 2000...
  62. ncbi Association of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments
    K Hirao
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    Genes Cells 5:203-10. 2000
    ..We have further characterized here the Triton X-100-insolubility of SAPAP and tried to identify the Triton X-100-insoluble structures which SAPAP interacts with...
  63. ncbi Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein
    K Hirao
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, JCR Pharmaceuticals Company Limited, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 275:2966-72. 2000
    ..S-SCAM, PSD-95/SAP90, and SAPAP are colocalized at least in some part in brain. Therefore, S-SCAM, PSD-95/SAP90, and SAPAP may form a complex in vivo...
  64. ncbi Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain
    H Hibino
    Departments of Pharmacology II, Graduate School of Medicine, Osaka University, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    EMBO J 19:78-83. 2000
    ..2c channel to G protein stimulation. Furthermore, SAPAP1/GKAP, which binds specifically to the GK domain of membrane-associated guanylate kinases, prevented the SAP97-..
  65. ncbi Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95
    M Passafaro
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, HHMI Wellman 423, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 2:1063-9. 1999
    ..the association of PSD-95 with microtubules and inhibited the synaptic clustering of PSD-95, chapsyn-110/PSD-93 and GKAP (a PSD-95-binding protein)...
  66. ncbi Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family
    T M Boeckers
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, 39118, Germany
    Biochem Biophys Res Commun 264:247-52. 1999
    ..the PDZ domains of ProSAP1 and 2 as bait in the yeast two-hybrid system, we isolated several clones of the SAPAP/GKAP (SAP90/PSD-95-associated protein/guanylate kinase-associated protein) family...
  67. ncbi Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development
    S Lim
    Department of Pharmacology, Pusan National University, Kumjeong Ku, Pusan 609 735, Korea
    J Biol Chem 274:29510-8. 1999
    ..Shank directly interacts with GKAP and Homer, thus potentially bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer ..
  68. ncbi Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
    J C Tu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 23:583-92. 1999
    ..clusters mGluR5 in heterologous cells in the presence of Homer and mediates the coclustering of Homer with PSD-95/GKAP. Thus, Shank may cross-link Homer and PSD-95 complexes in the PSD and play a role in the signaling mechanisms of ..
  69. ncbi The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis
    M L Liou
    Division of Immunology, Department of Medicine, Cornell University Medical College, New York, New York 10021, USA
    J Biol Chem 274:10145-53. 1999
    ..Collectively, these observations highly suggest a role for DAP-1 in mediating TNF-induced cell death signaling pathways, presumably through the recruitment of FADD death effector...
  70. ncbi Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions
    N Levy-Strumpf
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Oncogene 17:3331-40. 1998
    ....
  71. ncbi Differential expression of isoforms of PSD-95 binding protein (GKAP/SAPAP1) during rat brain development
    N Kawashima
    Department of Neurochemistry and Neuropharmacology, Biomedical Research Center, Osaka University Medical School, Suita, Japan
    FEBS Lett 418:301-4. 1997
    ..Here we report the isolation of new isoforms of PSD-95 binding protein (GKAP/SAPAP1) using the yeast two-hybrid system...
  72. ncbi Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90
    S Naisbitt
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachussetts 02114, USA
    J Neurosci 17:5687-96. 1997
    ..By yeast two-hybrid screening, a novel protein termed guanylate kinase-associated protein (GKAP) has been isolated that binds to the GK-like domain of PSD-95 ()...
  73. ncbi Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death
    L P Deiss
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genes Dev 9:15-30. 1995
    ..Altogether, it is suggested that these two novel genes are candidates for positive mediators of programmed cell death that is induced by IFN-gamma...
  74. ncbi The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif
    K W Lo
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    J Biol Chem 276:14059-66. 2001
    ..The role of each conserved amino acid residue in this pentapeptide motif in supporting complex formation with DLC8 was systematically studied using site-directed mutagenesis...
  75. ncbi Laminar organization of the NMDA receptor complex within the postsynaptic density
    J G Valtschanoff
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 21:1211-7. 2001
    ..The supramolecular organization of these molecules may modulate intracellular transduction of NMDA-mediated signals...
  76. ncbi Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain
    J Fan
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, Kowloon, P R China
    J Mol Biol 306:97-108. 2001
    ..protein designated Bim; a Drosophila RNA localization protein Swallow, myosin V, neuronal scaffolding protein GKAP, and IkappaBalpha, an inhibitor of the NFkappaB transcription factor...
  77. ncbi Ontogeny of postsynaptic density proteins at glutamatergic synapses
    Ronald S Petralia
    Laboratory of Neurochemistry, NIDCD NIH, 50 4142, 50 South Drive MSC 8027, Bethesda, MD 20892 8027, USA
    Mol Cell Neurosci 29:436-52. 2005
    ..NR2B and most GluR-associated proteins, including SAP102, SynGAP, the chain of proteins from GluRs/SAP102 through GKAP/Shank/Homer and metabotropic glutamate receptors, and the adhesion factors, cadherin, catenin, neuroligin, and Nr-..
  78. ncbi p55 protein is a member of PSD scaffold proteins in the rat brain and interacts with various PSD proteins
    Zhang Jing-Ping
    Department of Neuroplasticity, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Brain Res Mol Brain Res 135:204-16. 2005
    ..assay showed that r-p55 protein interacted with r-p55 itself and various PSD proteins, such as PSD-95, SAP97, GKAP, CASK, GRIP, neuroligin, cadherin, tubulin, actin, alpha-internexin, neurofilament-L and Ca(2+)/calmodulin-..
  79. ncbi p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
    Guadalupe Sabio
    MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
    EMBO J 24:1134-45. 2005
    ..and is targeted to the cytoskeleton by its association with the protein guanylate kinase-associated protein (GKAP)...
  80. ncbi Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes
    Genaro S Scavello
    Division of Ophthalmology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Mol Vis 11:97-110. 2005
    ..31 using 7 families diagnosed with autosomal dominant high myopia and was designated the MYP2 locus. To characterize this region, we analyzed 9 known candidate genes localized to within the 2.2 cM interval by direct sequencing...
  81. ncbi A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses
    Stefano Romorini
    Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Pharmacology, University of Milan, 20129 Milan, Italy
    J Neurosci 24:9391-404. 2004
    ..of Shank1 targeting and synapse assembly by looking at the function of guanylate kinase-associated protein (GKAP) and PSD-95 interactions...
  82. ncbi Cloning and expression of mars, a novel member of the guanylate kinase associated protein family in Drosophila
    Daimark Bennett
    Department of Zoology, Oxford University, Tinbergen Building, South Parks Road, Oxford OX1 3PS, UK
    Gene Expr Patterns 4:529-35. 2004
    ..Here we describe the identification of Mars, a novel Drosophila protein belonging to the GKAP family...
  83. ncbi In vitro study of molecular weight, hydrophobicity and amino acid composition of peptides during breakdown of a casein hydrolysate by two strains of Prevotella ruminicola
    N Depardon
    Laboratoire des Sciences Animales, Ensais Inra, Vandoeuvre, France
    Reprod Nutr Dev 38:567-76. 1998
    ..ruminicola differed with time and depended on the strain used. The nature of the enzyme activity and the use of other nitrogen sources may explain the difference between the two strains...
  84. ncbi Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse
    Jeffrey M Welch
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 472:24-39. 2004
    ..Furthermore, SAPAP3 mRNA is targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies...
  85. ncbi Crystallization and preliminary X-ray crystallographic studies of the PDZ domain of Shank1 from Rattus norvegicus
    Seong Ho Park
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    Acta Crystallogr D Biol Crystallogr 58:1353-5. 2002
    ..The PDZ domain of Shank binds to the C-terminus of guanylate kinase-associated protein (GKAP)...
  86. ncbi Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97
    Nikolaj Klocker
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Eur J Neurosci 16:1517-22. 2002
    ..Synaptic clustering of the guanylate kinase domain interacting protein GKAP was also intact...
  87. ncbi Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases
    Olav Olsen
    Department of Physiology and Program in Neuroscience, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Biol Chem 278:6873-8. 2003
    ..Protein ligands for the PSD-95 guanylate kinase domain, guanylate kinase-associated protein (GKAP) and MAP1A, appear not to interact with the canonical GMP binding pocket, and GMP binding does not influence the ..
  88. ncbi Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1
    K K Perkins
    Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley, CA 94720
    EMBO J 7:4265-73. 1988
    ..The Drosophila Jun- and Fos-related antigens, when separated, are individually capable of sequence-specific DNA binding, and the Jun-related antigen activates transcription in vitro...
  89. ncbi Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin
    Shinichi Usui
    Department of Neuroscience D13, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Japan
    J Biol Chem 278:10619-28. 2003
    ..C-terminal leucine zipper motif markedly suppressed the synaptic localization of endogenous shank but not PSD-95 or GKAP. In contrast, an overexpressed GKAP mutant lacking shank binding activity had no effect on the synaptic ..
  90. ncbi Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling
    James G Dobson
    Genomic Physiology Group, Department of Physiology, University of Massachusetts Medical School, Worcester 01655, USA
    Physiol Genomics 15:142-7. 2003
    ..Although these results do not prove causality, they demonstrate that cardiac aging is associated with changes in the profiles of gene expression and that many of these changes may contribute to reduced adrenergic signaling...
  91. ncbi A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins
    Tatsuo Suzuki
    Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Eur J Neurosci 21:339-50. 2005
    ..study showed TANC association with various postsynaptic proteins, including guanylate kinase-associated protein (GKAP), alpha-internexin, and N-methyl-D-aspartate (NMDA)-type glutamate receptor 2B and AMPA-type glutamate receptor (..
  92. ncbi A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
    K Hirao
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 273:21105-10. 1998
    ..kinases and binds N-methyl-D-aspartate receptors, potassium channels, and neuroligins through the PDZ domains and GKAP/SAPAP/DAP through the guanylate kinase (GK) domain...
  93. ncbi Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization
    Young Jun Im
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    J Biol Chem 278:48099-104. 2003
    ..This configuration may provide a means of facilitating dimeric organization of PDZ-target assemblies...
  94. ncbi SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density
    M Takeuchi
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co, Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 22, Japan
    J Biol Chem 272:11943-51. 1997
    ..SAPAPs induce the enrichment of PSD-95/SAP90 to the plasma membrane in transfected cells. Thus, SAPAPs may have a potential activity to maintain the structure of PSD by concentrating its components to the membrane area...
  95. ncbi nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP)
    H Kawabe
    Department of Molecular Biology, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Biol Chem 274:30914-8. 1999
    ..nArgBP2 bound to not only SAPAP but also vinculin and l-afadin, known to bind to ponsin and vinexin. nArgBP2 may be implicated in the protein network around SAPAP in the PSD...

Research Grants61

  1. Glutamate Receptor Trafficking in Visual Development
    Martha Constantine Paton; Fiscal Year: 2005
    ..trafficking of the NMDA receptor and its mature scaffolding complex, the postsynaptic density proteins PSD-95 and GKAP-95...
  2. Vanilloid Receptor VR1 in Osteoarthritis
    Juli Valtschanoff; Fiscal Year: 2009
    ....
  3. Postsynaptic Protein Trafficking and Synapse Remodeling
    Sang H Lee; Fiscal Year: 2010
    ..Among the activity-regulated proteins, GKAP is one of the major scaffolding proteins in the postsynaptic densities and provides a molecular link for PSD-95/..
  4. Postsynaptic Protein Trafficking and Synapse Remodeling
    Sang H Lee; Fiscal Year: 2011
    ..Among the activity-regulated proteins, GKAP is one of the major scaffolding proteins in the postsynaptic densities and provides a molecular link for PSD-95/..
  5. NITRIC OXIDE SIGNALING MECHANISMS IN VASCULAR CELLS
    Michael Mendelsohn; Fiscal Year: 2004
    ..MBS and RGS2 are thus members of a newly emerging family of PKG-anchoring proteins (GKAP)...
  6. Targeting mechanisms of cGMP dependent protein kinases by peptide arrays and crys
    CHOEL WOONG KIM; Fiscal Year: 2010
    ..Despite mounting evidence that GKAP target PKGs via its association with the zipper domain, the molecular details of this important protein- protein ..
  7. Modulation and Targeting of Kainate Receptors
    John Marshall; Fiscal Year: 2004
    ..For potential mechanisms, we will examine how binding of ligands, such as GKAP, to the GK domain may promote the association of the SH3 domain of PSD-95 with KA2, the molecular sites on KA2 and ..
  8. Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior
    Guoping Feng; Fiscal Year: 2007
    ..SAPAP family proteins (SAPAP1-4) were originally identified as proteins interacting with PSD95 family and Shank family proteins, two other major ..
  9. Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior
    Guoping Feng; Fiscal Year: 2009
    ..SAPAP family proteins (SAPAP1-4) were originally identified as proteins interacting with PSD95 family and Shank family proteins, two other major ..
  10. Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior
    Guoping Feng; Fiscal Year: 2010
    ..SAPAP family proteins (SAPAP1-4) were originally identified as proteins interacting with PSD95 family and Shank family proteins, two other major ..
  11. CLUSTERING AND TARGETING ION CHANNELS TO THE SYNAPSE
    Vivian Budnik; Fiscal Year: 2002
    ..Studies in mammals have identified a novel protein, GKAP, which interacts with the guanylate kinase domain of the vertebrate MAGUK, PSD-95...
  12. Regulation of the NMDA Receptor Signaling Complex
    Richard Huganir; Fiscal Year: 2006
    ..is a component of the NMDA receptor complex that also interacts with several other synaptic proteins including GKAP, Homer and metabotropic glutamate receptors...
  13. Myocardial Adenosine Receptors
    James G Dobson; Fiscal Year: 2010
    ..Such information should be instrumental for the development of new therapies and agents to alleviate cardiac dysfunction. ..
  14. Myocardial Adenosine Receptors
    James Dobson; Fiscal Year: 2009
    ..Such information should be instrumental for the development of new therapies and agents to alleviate cardiac dysfunction. ..
  15. Light activated bioactive substrate release
    RICHARD GIVENS; Fiscal Year: 2007
    ..abstract_text> ..
  16. Vanilloid Receptor VR1 in Osteoarthritis
    Juli Valtschanoff; Fiscal Year: 2007
    ....
  17. Vanilloid Receptors in Nociception
    Juli Valtschanoff; Fiscal Year: 2004
    ..abstract_text> ..
  18. MECHANISMS OF AGING--ENHANCED HEART ADENOSINE
    James Dobson; Fiscal Year: 1993
    ..This project represents a relatively new concept involving adenosine that may be important in explaining the decrement of beta-adrenergic responsiveness of the mammalian heart observed with aging...
  19. ADENOSINE A1 AND A2 RECEPTORS IN THE MYOCARDIUM
    James Dobson; Fiscal Year: 2004
    ..Additionally, the findings should significantly contribute to our basic knowledge of the molecular mechanisms of G protein coupled receptor cross-regulation in the heart. ..