Gene Symbol: DLG1
Description: discs large MAGUK scaffold protein 1
Alias: DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, disks large homolog 1, discs large homolog 1, scribble cell polarity complex component, discs, large homolog 1 transcript variant 6-v1, discs, large homolog 1 transcript variant 6-v2, presynaptic protein SAP97, synapse-associated protein 97
Species: human
Products:     DLG1

Top Publications

  1. Hanada T, Lin L, Tibaldi E, Reinherz E, Chishti A. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. J Biol Chem. 2000;275:28774-84 pubmed
    ..we reported cloning of the human lymphocyte homologue of the Drosophila Discs Large tumor suppressor protein (hDlg). Here we show that a novel protein termed GAKIN binds to the guanylate kinase-like domain of hDlg...
  2. Marcello E, Epis R, Saraceno C, Gardoni F, Borroni B, Cattabeni F, et al. SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus. Neurobiol Aging. 2012;33:422.e1-10 pubmed publisher
    Synapse-asssociated protein-97 (SAP97) is responsible for the trafficking of both glutamate receptor subunits, GluR1 and NR2A, and ?-secretase ADAM10 to the synaptic membrane...
  3. Lue R, Brandin E, Chan E, Branton D. Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain. J Cell Biol. 1996;135:1125-37 pubmed
    b>hDlg, a human homologue of the Drosophila Dig tumor suppressor, contains two binding sites for protein 4.1, one within a domain containing three PSD-95/Dlg/ZO-1 (PDZ) repeats and another within the alternatively spliced I3 domain...
  4. Narayan N, Massimi P, Banks L. CDK phosphorylation of the discs large tumour suppressor controls its localisation and stability. J Cell Sci. 2009;122:65-74 pubmed publisher
    ..The human homologue DLG1 is thought to be a tumour suppressor, through formation of a complex with the APC (adenomatous polyposis coli) ..
  5. Ishidate T, Matsumine A, Toyoshima K, Akiyama T. The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene. 2000;19:365-72 pubmed
    ..The carboxyl-terminal S/TXV motif of the APC gene product interacts with the PDZ domain of hDLG, the human homolog of the Drosophila lethal (1) discs larige-1 (dlg) tumor suppressor...
  6. Adey N, Huang L, Ormonde P, Baumgard M, Pero R, Byreddy D, et al. Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Cancer Res. 2000;60:35-7 pubmed
    Two-hybrid searches with the tumor suppressor MMAC1/PTEN isolated the proteins hDLG and hMAST205...
  7. Haq S, Jürgens M, Chi C, Koh C, Elfström L, Selmer M, et al. The plastic energy landscape of protein folding: a triangular folding mechanism with an equilibrium intermediate for a small protein domain. J Biol Chem. 2010;285:18051-9 pubmed publisher
    ..Here, we solved the crystal structure of a small protein domain, SAP97 PDZ2 I342W C378A, and determined its folding pathway...
  8. Sotelo N, Valiente M, Gil A, Pulido R. A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains. J Cell Biochem. 2012;113:2661-70 pubmed publisher
    APC and PTEN are tumor suppressor proteins that bind through their C-termini to the PDZ domain containing-hDlg scaffolding protein...
  9. Lasserre R, Charrin S, Cuche C, Danckaert A, Thoulouze M, de Chaumont F, et al. Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. EMBO J. 2010;29:2301-14 pubmed publisher
    ..ezrin regulates immune synapse architecture and T-cell activation through its interaction with the scaffold protein Dlg1. These results uncover a crucial function for ezrin, Dlg1 and microtubules in the organization of the immune ..

More Information


  1. Kiyono T, Hiraiwa A, Fujita M, Hayashi Y, Akiyama T, Ishibashi M. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A. 1997;94:11612-6 pubmed
    ..can bind to the second PDZ domain of the human homologue of the Drosophila discs large tumor suppressor protein (hDLG) through their C-terminal XS/TXV/L (where X represents any amino acid, S/T serine or threonine, and V/L valine or ..
  2. Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, et al. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. Genes Cells. 1997;2:415-24 pubmed
    The human homologue of the Drosophila discs large tumour suppressor protein (hDLG) and closely related proteins such as postsynaptic density protein 95 kDa (PSD-95) are associated with N-methyl-D-aspartate receptors (NMDA-R) and Shaker-..
  3. Lee S, Weiss R, Javier R. Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A. 1997;94:6670-5 pubmed
    ..found that the 9ORF1 protein interacts directly, in vitro and in vivo, with the PDZ domain-containing protein hDlg/SAP97 (DLG), which is a mammalian homolog of the Drosophila discs large tumor suppressor protein and which also binds ..
  4. Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. J Biol Chem. 1997;272:11943-51 pubmed
    ..SAPAPs induce the enrichment of PSD-95/SAP90 to the plasma membrane in transfected cells. Thus, SAPAPs may have a potential activity to maintain the structure of PSD by concentrating its components to the membrane area. ..
  5. Perugi F, Muriaux D, Ramirez B, Chabani S, Decroly E, Darlix J, et al. Human Discs Large is a new negative regulator of human immunodeficiency virus-1 infectivity. Mol Biol Cell. 2009;20:498-508 pubmed publisher
    ..We report here that human Discs Large (Dlg1), a scaffold protein recruited beneath the plasma membrane and involved in the assembly of multiprotein complexes, ..
  6. Watson R, Rollason T, Reynolds G, Murray P, Banks L, Roberts S. Changes in expression of the human homologue of the Drosophila discs large tumour suppressor protein in high-grade premalignant cervical neoplasias. Carcinogenesis. 2002;23:1791-6 pubmed
    ..oncoproteins, including the E6 protein of oncogenic human papillomaviruses, bind to the human homologue of Dlg (hDlg) supports this proposition...
  7. Lee C, Laimins L. Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31. J Virol. 2004;78:12366-77 pubmed
    ..These include hDlg, hScrib, MAGI-1, MAGI-2, MAGI-3, and MUPP1...
  8. McLaughlin M, Hale R, Ellston D, Gaudet S, Lue R, Viel A. The distribution and function of alternatively spliced insertions in hDlg. J Biol Chem. 2002;277:6406-12 pubmed
    b>hDlg is the human homolog of the Drosophila Discs-large tumor suppressor...
  9. Bassand P, Bernard A, Rafiki A, Gayet D, Khrestchatisky M. Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97. Eur J Neurosci. 1999;11:2031-43 pubmed
    ..The NR2B subunit interacts with post-synaptic density protein 95 (PSD-95), SAP97 and members of the membrane-associated guanylate-like kinase (MAGUK) family of proteins...
  10. Round J, Tomassian T, Zhang M, Patel V, Schoenberger S, Miceli M. Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells. J Exp Med. 2005;201:419-30 pubmed
    ..Here, we elucidate a role for the MAGUK protein, Dlgh1, in polarized T cell synapse assembly and T cell function...
  11. Sabio G, Arthur J, Kuma Y, Peggie M, Carr J, Murray Tait V, et al. p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J. 2005;24:1134-45 pubmed
    ..Here we identify SAP97/hDlg, the mammalian homologue of the Drosophila tumour suppressor Dlg, as a physiological substrate for the ..
  12. Brenman J, Topinka J, Cooper E, McGee A, Rosen J, Milroy T, et al. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J Neurosci. 1998;18:8805-13 pubmed
  13. Iñesta Vaquera F, Campbell D, Arthur J, Cuenda A. ERK5 pathway regulates the phosphorylation of tumour suppressor hDlg during mitosis. Biochem Biophys Res Commun. 2010;399:84-90 pubmed publisher
    Human disc-large (hDlg) is a scaffold protein critical for the maintenance of cell polarity and adhesion. hDlg is thought to be a tumour suppressor that regulates the cell cycle and proliferation...
  14. Kim E, Naisbitt S, Hsueh Y, Rao A, Rothschild A, Craig A, et al. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J Cell Biol. 1997;136:669-78 pubmed
  15. von Ossowski I, Oksanen E, von Ossowski L, Cai C, Sundberg M, Goldman A, et al. Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide. FEBS J. 2006;273:5219-29 pubmed
    ..of GluR-A subunit-containing glutamate receptors involves an interaction with synapse-associated protein 97 (SAP97)...
  16. Niethammer M, Kim E, Sheng M. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci. 1996;16:2157-63 pubmed
    ..Members of the PSD-95 family might serve to anchor NMDA receptors to the submembrane cytoskeleton and aid in the assembly of signal transduction complexes at postsynaptic sites. ..
  17. Kim E, Niethammer M, Rothschild A, Jan Y, Sheng M. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature. 1995;378:85-8 pubmed
    ..3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization. ..
  18. Unno K, Hanada T, Chishti A. Functional involvement of human discs large tumor suppressor in cytokinesis. Exp Cell Res. 2008;314:3118-29 pubmed publisher
    ..We found that the human discs large (hDlg) tumor suppressor homologue is functionally involved in cytokinesis...
  19. O Neill A, Gallegos L, Justilien V, Garcia E, Leitges M, Fields A, et al. Protein kinase C? promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). J Biol Chem. 2011;286:43559-68 pubmed publisher
    ..Specifically, use of a proteomic array containing 96 purified PDZ domains identified the third PDZ domains of DLG1/SAP97 and DLG4/PSD95 as interaction partners for the PDZ binding motif of PKC?...
  20. Laprise P, Viel A, Rivard N. Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. J Biol Chem. 2004;279:10157-66 pubmed
    ..Here we provide evidence that hDlg, the homolog of disc-large tumor suppressor, is another key regulator of adherens junction integrity and ..
  21. Roberts S, Calautti E, Vanderweil S, Nguyen H, Foley A, Baden H, et al. Changes in localization of human discs large (hDlg) during keratinocyte differentiation are [corrected] associated with expression of alternatively spliced hDlg variants. Exp Cell Res. 2007;313:2521-30 pubmed
    Alternative spliced variants of the human discs large (hDlg) tumour suppressor are characterized by combinations of insertions...
  22. Paarmann I, Spangenberg O, Lavie A, Konrad M. Formation of complexes between Ca2+.calmodulin and the synapse-associated protein SAP97 requires the SH3 domain-guanylate kinase domain-connecting HOOK region. J Biol Chem. 2002;277:40832-8 pubmed
    Mammalian synapse-associated protein SAP97, a structural and functional homolog of Drosophila Dlg, is a membrane-associated guanylate kinase (MAGUK) that is present at pre- and postsynaptic sites as well as in epithelial cell-cell ..
  23. Gardiol D, Galizzi S, Banks L. Mutational analysis of the discs large tumour suppressor identifies domains responsible for human papillomavirus type 18 E6-mediated degradation. J Gen Virol. 2002;83:283-9 pubmed
    ..These results suggest that there are at least two mechanisms for regulating Dlg protein stability and that the pathways used by E6 are not necessarily the same as those used in the cell in its absence. ..
  24. Wu H, Reissner C, Kuhlendahl S, Coblentz B, Reuver S, Kindler S, et al. Intramolecular interactions regulate SAP97 binding to GKAP. EMBO J. 2000;19:5740-51 pubmed
    ..In this study, we examined the molecular mechanisms that regulate the interaction of the MAGUK SAP97 with its GUK domain binding partner GKAP (GUK-associated protein)...
  25. Kim E, Sheng M. Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases. Neuropharmacology. 1996;35:993-1000 pubmed
    ..their cytoplasmic C-terminus with a family of membrane-associated putative guanylate kinases, including PSD-95 and SAP97. We show here that heterologous coexpression of either sap97 or PSD-95 with various Shaker-type subunits results ..
  26. Wu H, Nash J, Zamorano P, Garner C. Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking. J Biol Chem. 2002;277:30928-34 pubmed
    b>SAP97 is a modular protein composed of three PDZ domains, an SH3 domain, and a guanylate kinase-like domain...
  27. Lue R, Marfatia S, Branton D, Chishti A. Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc Natl Acad Sci U S A. 1994;91:9818-22 pubmed
    ..This human homologue of Drosophila discs large (hdlg) contains a C-terminal domain homologous to the known guanylate kinases, a src homology 3 region motif, and three ..
  28. Marcello E, Gardoni F, Mauceri D, Romorini S, Jeromin A, Epis R, et al. Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity. J Neurosci. 2007;27:1682-91 pubmed
    ..In fact, we report that synapse-associated protein-97 (SAP97), a protein involved in dynamic trafficking of proteins to the excitatory synapse, is responsible for driving ..
  29. Maïga O, Philippe M, Kotelevets L, Chastre E, Benadda S, Pidard D, et al. Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large. FEBS J. 2011;278:2655-65 pubmed publisher
    Human disc-large homolog (hDlg), also known as synapse-associated protein 97, is a scaffold protein, a member of the membrane-associated guanylate kinase family, implicated in neuronal synapses and epithelial-epithelial cell junctions ..
  30. Reuver S, Garner C. E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton. J Cell Sci. 1998;111 ( Pt 8):1071-80 pubmed
    ..In this study, we have examined the mechanism that localizes one member, SAP97, to sites of cell-cell contact...
  31. Krishna Subbaiah V, Massimi P, Boon S, Myers M, Sharek L, Garcia Mata R, et al. The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. PLoS Pathog. 2012;8:e1002543 pubmed publisher
    A major target of the HPV E6 oncoprotein is the human Discs Large (hDlg) tumour suppressor, although how this interaction contributes to HPV-induced malignancy is still unclear...
  32. Gaudet S, Branton D, Lue R. Characterization of PDZ-binding kinase, a mitotic kinase. Proc Natl Acad Sci U S A. 2000;97:5167-72 pubmed
    b>hDlg, the human homologue of the Drosophila Discs-large (Dlg) tumor suppressor protein, is known to interact with the tumor suppressor protein APC and the human papillomavirus E6 transforming protein...
  33. Colledge M, Dean R, Scott G, Langeberg L, Huganir R, Scott J. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron. 2000;27:107-19 pubmed
    ..into a macromolecular signaling complex through direct interaction between the MAGUK proteins, PSD-95 and SAP97, and AKAP79/150. The SH3 and GK regions of the MAGUKs mediate binding to the AKAP...
  34. Sans N, Racca C, Petralia R, Wang Y, McCallum J, Wenthold R. Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. J Neurosci. 2001;21:7506-16 pubmed
    ..Synapse-associated protein 97 (SAP97), a member of the membrane-associated guanylate kinase family, is believed to associate with AMPA receptors (..
  35. Blot V, Delamarre L, Perugi F, Pham D, B nichou S, Benarous R, et al. Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes. J Cell Sci. 2004;117:3983-93 pubmed publisher
    Human homologue of the Drosophila Dlg tumor suppressor (hDlg) is a widely expressed scaffold protein implicated in the organization of multi-protein complexes at cell adhesion sites such as the neuronal synapse...
  36. Cavatorta A, Fumero G, Chouhy D, Aguirre R, Nocito A, Giri A, et al. Differential expression of the human homologue of drosophila discs large oncosuppressor in histologic samples from human papillomavirus-associated lesions as a marker for progression to malignancy. Int J Cancer. 2004;111:373-80 pubmed
    ..Dlg downregulation and/or alterations in its localization may contribute to transformation and may explain some of the characteristics of the malignant cells, such as loss of polarity and high migration ability. ..
  37. Surena A, de Faria G, Studler J, Peiretti F, Pidoux M, Camonis J, et al. DLG1/SAP97 modulates transforming growth factor alpha bioavailability. Biochim Biophys Acta. 2009;1793:264-72 pubmed publisher
    ..DLG1/SAP97 (Discs Large Gene 1 or Synapse Associated Protein 97) was found to interact with both pro-TGFalpha and TACE ICDs through distinct PDZ domains...
  38. Mulle J, Dodd A, McGrath J, Wolyniec P, Mitchell A, Shetty A, et al. Microdeletions of 3q29 confer high risk for schizophrenia. Am J Hum Genet. 2010;87:229-36 pubmed publisher
    ..contains two linkage peaks from prior SZ family studies, and the minimal deletion interval implicates 20 annotated genes, including PAK2 and DLG1, both paralogous to X-linked ID genes and now strong candidates for SZ susceptibility.
  39. Sato J, Shimazu D, Yamamoto N, Nishikawa T. An association analysis of synapse-associated protein 97 (SAP97) gene in schizophrenia. J Neural Transm (Vienna). 2008;115:1355-65 pubmed publisher
    b>SAP97 gene encodes the synaptic scaffolding PDZ proteins that interact with the L: -alpha-amino-3-hydroxyl-5-methylisoxazole-4-propionate (AMPA), kainate and N-methyl-D: -aspartate (NMDA) type glutamate receptors...
  40. Garcia Mata R, Dubash A, Sharek L, Carr H, Frost J, Burridge K. The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Mol Cell Biol. 2007;27:8683-97 pubmed
    ..that Net1 interacts through its PDZ-binding motif with tumor suppressor proteins of the Dlg family, including Dlg1/SAP97, SAP102, and PSD95...
  41. Nicolaides L, Davy C, Raj K, Kranjec C, Banks L, Doorbar J. Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance. Virology. 2011;414:137-45 pubmed publisher
  42. Karnak D, Lee S, Margolis B. Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97. J Biol Chem. 2002;277:46730-5 pubmed
    ..An additional domain we identified in SAP97 called the MAGUK recruitment (MRE) domain binds the LIN-2,7 amino-terminal (L27N) domain of mLIN-2/CASK, a MAGUK ..
  43. Hanada T, Lin L, Chandy K, Oh S, Chishti A. Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes. J Biol Chem. 1997;272:26899-904 pubmed
    Human homologue of the Drosophila discs large tumor suppressor protein (hDlg) belongs to a newly discovered family of proteins termed MAGUKs that appear to have structural as well as signaling functions...
  44. Kawabe H, Nakanishi H, Asada M, Fukuhara A, Morimoto K, Takeuchi M, et al. Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. J Biol Chem. 2001;276:48350-5 pubmed
    ..The present results indicate that Pilt is a novel component of TJs. ..
  45. White S, Ortinski P, Friedman S, Zhang L, Neve R, Kalb R, et al. A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking. Neuropsychopharmacology. 2016;41:736-50 pubmed publisher
    ..b>SAP97 and 4...
  46. Deguchi M, Hata Y, Takeuchi M, Ide N, Hirao K, Yao I, et al. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. J Biol Chem. 1998;273:26269-72 pubmed
    ..BEGAIN may be a novel PSD component associated with the core complex of PSD-95/SAP90 and SAPAP. ..
  47. Xu S, Zhou F, Tao J, Song L, Ng S, Wang X, et al. Exome sequencing identifies DLG1 as a novel gene for potential susceptibility to Crohn's disease in a Chinese family study. PLoS ONE. 2014;9:e99807 pubmed publisher
    ..374T>C (p.I125T) in exon 4 of discs large homolog 1 (DLG1), a gene has been reported to play multiple roles in cell proliferation, T cell polarity and T cell receptor ..
  48. Suzuki T, Li W, Zhang J, Tian Q, Sakagami H, Usuda N, et al. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. Eur J Neurosci. 2005;21:339-50 pubmed
    ..Pull-down experiments showed that TANC protein bound PSD-95, SAP97, and Homer via its C-terminal PDZ-binding motif, -ESNV, and fodrin via both its ankyrin repeats and the TPRs ..
  49. Li Z, Benard O, Margolskee R. Ggamma13 interacts with PDZ domain-containing proteins. J Biol Chem. 2006;281:11066-73 pubmed
    ..specifically with the third PDZ domain of PSD95, the sole PDZ domain of Veli-2, and the third PDZ domain of SAP97, a PSD95-related protein. Ggamma13 did not interact with the other PDZ domains of PSD95...
  50. Du M, Fan X, Hanada T, Gao H, Lutchman M, Brandsma J, et al. Association of cottontail rabbit papillomavirus E6 oncoproteins with the hDlg/SAP97 tumor suppressor. J Cell Biochem. 2005;94:1038-45 pubmed
    ..Here we describe the association of CRPV E6s with hDlg/SAP97, the mammalian homolog of the Drosophila discs large tumor suppressor protein...
  51. Goellner G, DeMarco S, Strehler E. Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants. Ann N Y Acad Sci. 2003;986:461-71 pubmed
    ..Our data suggest that PISP is a transiently interacting partner of the PMCA b-splice forms that may play a role in their sorting to or from the plasma membrane. ..
  52. Carr H, Cai C, Keinanen K, Frost J. Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activity. J Biol Chem. 2009;284:24269-80 pubmed publisher
    ..In the present work, we demonstrate that Net1 binds directly to the first two PDZ domains of Dlg1 and that both PDZ domains are required for maximal interaction in cells...
  53. Westland R, Verbitsky M, Vukojevic K, Perry B, Fasel D, Zwijnenburg P, et al. Copy number variation analysis identifies novel CAKUT candidate genes in children with a solitary functioning kidney. Kidney Int. 2015;88:1402-1410 pubmed publisher
    ..Among these genes, DLG1 and KIF12 are likely novel susceptibility genes for CAKUT in humans...
  54. Yamada K, Hanada T, Chishti A. The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B. Biochemistry. 2007;46:10039-45 pubmed
    ..of the kinesin-3 motor protein, GAKIN, is regulated by the direct binding of its protein cargo, human discs large (hDlg) tumor suppressor...
  55. Mahoney Z, Sammut B, Xavier R, Cunningham J, Go G, Brim K, et al. Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci U S A. 2006;103:19872-7 pubmed
    Discs-large homolog 1 (DLGH1) is a mouse ortholog of the Drosophila discs-large (DLG) tumor suppressor protein, a founding member of the PDZ and MAGUK protein families...
  56. Mathur R, Choi W, Eldstrom J, Wang Z, Kim J, Steele D, et al. A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97. Biochem Biophys Res Commun. 2006;342:1-8 pubmed
    We have previously reported that SAP97 enhancement of hKv1.5 currents requires an intact Kv1.5 N-terminus and is independent of the PDZ-binding motif at the C-terminus of the channel [J. Eldstrom, W.S. Choi, D.F. Steele, D...
  57. Dunn H, Walther C, Godin C, Hall R, Ferguson S. Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling. J Biol Chem. 2013;288:15023-34 pubmed publisher
    ..In this study, we found that CRFR1 interacts with synapse-associated protein 97 (SAP97; also known as DLG1) by co-immunoprecipitation in human embryonic 293 (HEK 293) cells and cortical brain lysates ..
  58. Stephenson J, Paavola K, Schaefer S, Kaur B, Van Meir E, Hall R. Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density. J Biol Chem. 2013;288:22248-56 pubmed publisher
    ..These findings demonstrate that BAI1 is a synaptic receptor that can activate both the Rho and ERK pathways, with the N-terminal and C-terminal regions of the receptor playing key roles in the regulation of BAI1 signaling activity. ..
  59. Dunn H, Walther C, Yuan G, Caetano F, Godin C, Ferguson S. Role of SAP97 in the regulation of 5-HT2AR endocytosis and signaling. Mol Pharmacol. 2014;86:275-83 pubmed publisher
    ..In the present study, we found that 5-HT2AR interacts with synapse-associated protein 97 (SAP97; also known as DLG1) by coimmunoprecipitation in human embryonic 293 (HEK 293) cells and cortical brain lysates...
  60. Nix S, Chishti A, Anderson J, Walther Z. hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions. J Biol Chem. 2000;275:41192-200 pubmed
    ..We now report that hCASK binds another MAGUK, human discs large (hDlg)...
  61. Uezato A, Yamamoto N, Iwayama Y, Hiraoka S, Hiraaki E, Umino A, et al. Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. Transl Psychiatry. 2015;5:e654 pubmed publisher
    The human discs, large homolog 1 gene (DLG1) is mapped to the schizophrenia-susceptibility locus 3q29, and it encodes a scaffold protein that interacts with the N-methyl-D-aspartate receptor presumably dysregulated in schizophrenia...
  62. Kumar M, Kong K, Javier R. Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins. J Virol. 2014;88:14268-77 pubmed publisher
    ..activates PI3K by a novel mechanism involving separate interactions of E4-ORF1 with cellular discs large 1 (Dlg1) and PI3K to form a ternary complex that translocates to the plasma membrane (K. Kong, M. Kumar, M. Taruishi, and R...
  63. Law R, Law H, Scurll J, Scholz R, Santos A, Shames S, et al. Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors. J Proteome Res. 2016;15:1613-22 pubmed publisher