DLAT

Summary

Gene Symbol: DLAT
Description: dihydrolipoamide S-acetyltransferase
Alias: DLTA, PDC-E2, PDCE2, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, E2 component of pyruvate dehydrogenase complex, M2 antigen complex 70 kDa subunit, PBC, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial, dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, pyruvate dehydrogenase complex component E2
Species: human

Top Publications

  1. ncbi Nucleotide sequence of a cDNA encoding the lipoate acetyl transferase (E2) of human heart pyruvate dehydrogenase complex differs from that of human placenta
    L H Moehario
    Department of Biochemistry, Monash University, Clayton, Vic, Australia
    Biochem Int 20:417-22. 1990
  2. pmc The Bacillus subtilis extracytoplasmic function σ factor σ(V) is induced by lysozyme and provides resistance to lysozyme
    Theresa D Ho
    Department of Microbiology, Carver College of Medicine, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
    J Bacteriol 193:6215-22. 2011
  3. ncbi Three-dimensional structure of the major autoantigen in primary biliary cirrhosis
    M J Howard
    Department of Biochemistry, Cambridge Centre for Molecular Recognition, University of Cambridge, England
    Gastroenterology 115:139-46. 1998
  4. ncbi Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components
    Yasuaki Hiromasa
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 279:6921-33. 2004
  5. ncbi Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
    Mary C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, Bart s and The London, Queen Mary s School of Medicine and Dentistry, University of London, Mile End Road, London E1 4NS, United Kingdom
    Am J Physiol Endocrinol Metab 284:E855-62. 2003
  6. pmc Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
    Masato Kato
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    EMBO J 24:1763-74. 2005
  7. pmc Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis
    R Klein
    Medizinische Klinik, University of Tubingen, Germany
    Clin Exp Immunol 92:308-16. 1993
  8. pmc A DltA mutant of Haemophilus ducreyi Is partially attenuated in its ability to cause pustules in human volunteers
    Diane Janowicz
    Department of Medicine, Indiana University, Indianapolis, IN 46202 5124, USA
    Infect Immun 74:1394-7. 2006
  9. ncbi Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation
    M Perego
    Dipartimento Farmaceutico, Facolta di Farmacia, Universita degli Studi di Parma, Italy
    J Biol Chem 270:15598-606. 1995
  10. ncbi [Quantitation of antigen specific T lymphocytes in peripheral blood of patients with primary biliary cirrhosis using tetramer technology]
    Hai Ying Liu
    Clinical Laboratory, General Hospital of Guangzhou, Guangzhou 510010, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:78-81. 2006

Research Grants

  1. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
  2. FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    ANGELA FOREMAN; Fiscal Year: 2006
  3. Dihydrolipoamide Acyltransferase:Target for Chemotherapy
    Carl Nathan; Fiscal Year: 2004
  4. Role of Apoptotic Cholangiocytes in PBC
    JOSEPH ODIN; Fiscal Year: 2005
  5. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL GERSHWIN; Fiscal Year: 2009
  6. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
  7. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
  8. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2009
  9. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL E GERSHWIN; Fiscal Year: 2010
  10. dnTGF Beta RII Mice and PBC
    William M Ridgway; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications129 found, 100 shown here

  1. ncbi Nucleotide sequence of a cDNA encoding the lipoate acetyl transferase (E2) of human heart pyruvate dehydrogenase complex differs from that of human placenta
    L H Moehario
    Department of Biochemistry, Monash University, Clayton, Vic, Australia
    Biochem Int 20:417-22. 1990
    ..This may indicate the existence of tissue-specific isoforms of the lipoate acetyl transferase component of pyruvate dehydrogenase complex coded for by a multi-gene family...
  2. pmc The Bacillus subtilis extracytoplasmic function σ factor σ(V) is induced by lysozyme and provides resistance to lysozyme
    Theresa D Ho
    Department of Microbiology, Carver College of Medicine, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
    J Bacteriol 193:6215-22. 2011
    ..In addition, we show that two ECF σ factor-regulated genes, dltA and pbpX, are required for lysozyme resistance. Thus, we have identified three independent mechanisms which B...
  3. ncbi Three-dimensional structure of the major autoantigen in primary biliary cirrhosis
    M J Howard
    Department of Biochemistry, Cambridge Centre for Molecular Recognition, University of Cambridge, England
    Gastroenterology 115:139-46. 1998
    Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by the presence of antimitochondrial autoantibodies in patients' serum...
  4. ncbi Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components
    Yasuaki Hiromasa
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 279:6921-33. 2004
    ..Twelve E3 dimers were bound per E248.E3BP12 mass, which is consistent with this model...
  5. ncbi Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
    Mary C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, Bart s and The London, Queen Mary s School of Medicine and Dentistry, University of London, Mile End Road, London E1 4NS, United Kingdom
    Am J Physiol Endocrinol Metab 284:E855-62. 2003
    ....
  6. pmc Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
    Masato Kato
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    EMBO J 24:1763-74. 2005
    ..We hypothesize that this allosteric mechanism accounts, in part, for E2p-augmented PDK3 activity...
  7. pmc Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis
    R Klein
    Medizinische Klinik, University of Tubingen, Germany
    Clin Exp Immunol 92:308-16. 1993
    Anti-M2 antibodies in primary biliary cirrhosis (PBC) have been shown to react with the alpha-ketoacid dehydrogenase complex of the inner mitochondrial membrane consisting of six epitopes (E2 subunit of the pyruvate dehydrogenase complex ..
  8. pmc A DltA mutant of Haemophilus ducreyi Is partially attenuated in its ability to cause pustules in human volunteers
    Diane Janowicz
    Department of Medicine, Indiana University, Indianapolis, IN 46202 5124, USA
    Infect Immun 74:1394-7. 2006
    Haemophilus ducreyi produces two outer membrane proteins, called DltA (H. ducreyi lectin A) and DsrA (H. ducreyi serum resistance A), that contribute to the ability of the organism to evade complement-mediated serum killing...
  9. ncbi Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation
    M Perego
    Dipartimento Farmaceutico, Facolta di Farmacia, Universita degli Studi di Parma, Italy
    J Biol Chem 270:15598-606. 1995
    ..The dlt operon contains five genes, dltA-dltE. Insertional inactivation of dltA-dltD results in complete absence of D-alanine from both LTA and WTA...
  10. ncbi [Quantitation of antigen specific T lymphocytes in peripheral blood of patients with primary biliary cirrhosis using tetramer technology]
    Hai Ying Liu
    Clinical Laboratory, General Hospital of Guangzhou, Guangzhou 510010, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:78-81. 2006
    To quantitate antigen specific T lymphocytes in peripheral blood from patients with primary biliary cirrhosis(PBC) and study the role of antigen specific T lymphocytes in the development of PBC.
  11. pmc A functional dlt operon, encoding proteins required for incorporation of d-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae
    Martá Kovács
    University of Kaiserslautern, Department of Microbiology, Paul Ehrlich Strasse 23, D 67663 Kaiserslautern, Germany
    J Bacteriol 188:5797-805. 2006
    ..pneumoniae strains, the laboratory strain R6 and the clinical isolate TIGR4. The annotation of dltA in R6 predicts a protein, d-alanine-d-alanyl carrier protein ligase (Dcl), that is shorter at the amino terminus ..
  12. ncbi Breakdown of tolerance to pyruvate dehydrogenase complex in experimental autoimmune cholangitis: a mouse model of primary biliary cirrhosis
    D E Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    Hepatology 30:65-70. 1999
    The autoimmune liver disease primary biliary cirrhosis (PBC) is characterized by autoreactive responses to a highly conserved self-antigen, pyruvate dehydrogenase complex (PDC)...
  13. doi Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
    Hannah R Walden
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:1874-84. 2008
    Lipoylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for autoreactive immune responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant auto-epitopes...
  14. ncbi Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis
    R K Thomson
    Tenovus Laboratory, and University Medicine, Southampton University Hospitals, UK
    J Hepatol 28:582-94. 1998
    ..The aim of this study was to generate and characterise human anti-PDC-E2 monoclonal antibodies and analyse immunoglobulin gene usage and mutation for clues to pathogenesis...
  15. doi Primary biliary cirrhosis following Lactobacillus vaccination for recurrent vaginitis
    Dimitrios Bogdanos
    Institute of Liver Studies, King s College, London School of Medicine at King s College Hospital, London, United Kingdom
    J Hepatol 49:466-73. 2008
    ..other mitochondrial 2-oxoacid dehydrogenases (AMA-M2) are the hallmark for diagnosis of primary biliary cirrhosis (PBC)...
  16. ncbi Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis
    Akira Kawano
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Immunol 179:3315-24. 2007
    ..These data highlight that costimulation plays a dominant role in maintaining peripheral tolerance to PBC-specific Ags...
  17. pmc Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes
    Kathleen H Cox
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e5366. 2009
    ..In this study, we have further investigated the effects that mutating dltA has on virulence factor expression in Streptococcus pyogenes.
  18. pmc Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory system
    C Poyart
    Laboratoire de Microbiologie, INSERM U 411, Faculte de Medecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    J Bacteriol 183:6324-34. 2001
    The dlt operon of gram-positive bacteria comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids (LTAs)...
  19. ncbi Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis
    M Yasoshima
    Department of Pathology II, Kanazawa University School of Medicine, Japan
    J Pathol 175:319-25. 1995
    ..Ten cases of primary biliary cirrhosis (PBC) and 19 controls were examined, including four cases of extrahepatic biliary obstruction, six of chronic viral ..
  20. pmc A novel lectin, DltA, is required for expression of a full serum resistance phenotype in Haemophilus ducreyi
    Isabelle Leduc
    Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Infect Immun 72:3418-28. 2004
    ..ducreyi. We describe here a second outer membrane protein, DltA (for ducreyi lectin A), which also contributes to serum resistance in H. ducreyi...
  21. ncbi PDC-E3BP is not a dominant T-cell autoantigen in primary biliary cirrhosis
    Anna McHugh
    Liver Research Group, University of Newcastle, Newcastle upon Tyne, UK
    Liver Int 26:406-13. 2006
    ..the E2 and E3BP components of pyruvate dehydrogenase complex (PDC), which characterise primary biliary cirrhosis (PBC) crossreact, precluding the identification, from serological studies, of the antigen to which the principal ..
  22. pmc Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly
    S Vijayakrishnan
    Division of Molecular and Cell Biology, Faculty of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK
    J Mol Biol 399:71-93. 2010
    ..The architectural complexity and lower stability of the E2/E3BP core may be of benefit to mammals, where sophisticated fine-tuning is required for cores with optimal catalytic and regulatory efficiencies...
  23. doi Length-dependent weakness and electrophysiological signs of secondary axonal loss in chronic inflammatory demyelinating polyradiculoneuropathy
    Thomas Harbo
    Department of Neurology, Aarhus University Hospital, Noerrebrogade 44, Aarhus C, Denmark
    Muscle Nerve 38:1036-45. 2008
    ..Conduction velocity (CV), distal latency (DLAT), minimal F-wave latency (FLAT), compound muscle action potential (CMAP), and amplitude decay between distal and ..
  24. pmc NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis
    Junichiro Irie
    Division of Rheumatology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Exp Med 203:1209-19. 2006
    Primary biliary cirrhosis (PBC) is an autoimmune disease with a strong genetic component characterized by biliary ductular inflammation with eventual liver cirrhosis...
  25. ncbi Role of charge properties of bacterial envelope in bactericidal action of human group IIA phospholipase A2 against Staphylococcus aureus
    Tomaz Koprivnjak
    Department of Microbiology, University of Iowa, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
    J Biol Chem 277:47636-44. 2002
    ..aureus, we examined the effects of mutations that prevent specific modifications of cell wall (dltA) and cell membrane (mprF) polyanions...
  26. ncbi Molecular cloning of dihydrolipoamide acetyltransferase of the rat pyruvate dehydrogenase complex: sequence comparison and evolutionary relationship to other dihydrolipoamide acyltransferases
    S Matuda
    Department of Biology, Kanoya National Institute of Fitness and Sports, Japan
    Biochim Biophys Acta 1131:114-8. 1992
    ..The E2 components of the three alpha-ketoacid dehydrogenase complexes are suggested to be classified into three clusters separated during evolution...
  27. ncbi The human biliary epithelial cell plasma membrane antigen in primary biliary cirrhosis: pyruvate dehydrogenase X?
    R E Joplin
    University Hospital, and Department of Medicine, University of Birmingham, England
    Gastroenterology 113:1727-33. 1997
    Patients with primary biliary cirrhosis (PBC) have autoantibodies that react with components of mitochondrial multienzyme complexes...
  28. pmc Molecular basis of resistance to muramidase and cationic antimicrobial peptide activity of lysozyme in staphylococci
    Silvia Herbert
    Microbial Genetics Department, University of Tubingen, Tubingen, Germany
    PLoS Pathog 3:e102. 2007
    ..7% decrease in the content of esterified d-alanyl groups in teichoic acids. The oatA/dltA double mutant showed the highest sensitivity to lysozyme; this mutant completely lacks teichoic acid-bound d-..
  29. ncbi The peculiar autoimmunity of primary biliary cirrhosis
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Rev 174:226-37. 2000
    Autoantibodies to mitochondria (AMA, anti-M2) are a serologic hallmark of primary biliary cirrhosis (PBC)...
  30. ncbi Enhanced secretion of heterologous cyclodextrin glycosyltransferase by a mutant of Bacillus licheniformis defective in the D-alanylation of teichoic acids
    M Craynest
    Vaccine Development Laboratory, National Public Health Institute, Helsinki, Finland
    Lett Appl Microbiol 37:75-80. 2003
    ..To examine whether inactivation of the dlt operon and increased charge density of the wall enhances secretion of heterologous proteins in industrial strains of Bacillus licheniformis...
  31. ncbi Queuine mediated inhibition in phosphorylation of tyrosine phosphoproteins in cancer
    Chandramani Pathak
    Biochemistry and Molecular Biology Laboratory, Center of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India
    Mol Biol Rep 35:369-74. 2008
    ..The result shows high level of cytosolic and membrane associated tyrosine phosphoprotein in DLAT cancerous mouse liver compared to normal...
  32. ncbi The causes of primary biliary cirrhosis: Convenient and inconvenient truths
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 47:737-45. 2008
    ..Primary biliary cirrhosis (PBC) is considered a model autoimmune disease because of its signature antimitochondrial autoantibody (AMA), the ..
  33. ncbi The pathogenesis of primary biliary cirrhosis
    J A Solis Herruzo
    Department of Digestive Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain
    Rev Esp Enferm Dig 101:413-23. 2009
    Primary biliary cirrhosis (PBC) would develop when the immune system comes across a microorganism with proteins similar to those in the piruvate dehydrogenase complex E2 (PDC-E2), or a neoantigen resulting from a xenobiotic-modified ..
  34. pmc Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA, USA
    Hepatology 52:987-98. 2010
    Our understanding of primary biliary cirrhosis (PBC) has been significantly enhanced by the rigorous dissection of the multilineage T and B cell response against the immunodominant mitochondrial autoantigen, the E2 component of the ..
  35. doi Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus
    Yukichika Tabuchi
    Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    J Immunol 185:2424-31. 2010
    ..A mutation of dltA, which is responsible for the D-alanylation of teichoic acids, brought about an increase in the survival rate of ..
  36. doi dltA gene mutation in the teichoic acids alanylation system of Lactococcus garvieae results in diminished proliferation in its natural host
    P Reimundo
    Area de Microbiologia, Departamento de Biologia Funcional, Facultad de Medicina, IUBA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain
    Vet Microbiol 143:434-9. 2010
    ..the role of this alanylation in the physiology and virulence of Lactococcus garvieae, a previously isolated dltA Delta Tn917 signature tagged mutagenesis (STM) clone was analyzed...
  37. ncbi D-alanyl ester depletion of teichoic acids in Lactobacillus reuteri 100-23 results in impaired colonization of the mouse gastrointestinal tract
    Jens Walter
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    Environ Microbiol 9:1750-60. 2007
    ..Insertional inactivation of the dltA gene resulted in complete depletion of D-alanine substitution of lipoteichoic acids...
  38. ncbi Hypomodification of transfer RNA in cancer with respect to queuosine
    Chandramani Pathak
    School of Studies in Biochemistry, Jiwaji University, Gwalior, India
    RNA Biol 2:143-8. 2005
    ..modification of transfer RNA and TGTase activity is compared in normal, Dalton's lymphoma ascites transplanted (DLAT) cancerous and queuine treated DLAT cancerous mouse liver...
  39. pmc Defects in D-alanyl-lipoteichoic acid synthesis in Streptococcus mutans results in acid sensitivity
    D A Boyd
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Bacteriol 182:6055-65. 2000
    ..3-kb deletion, one end of which was in dltB of the dlt operon encoding four proteins (DltA-DltD) involved in the synthesis of D-alanyl-lipoteichoic acid...
  40. pmc Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice
    Ling Jin
    Department of Biomedical Sciences, Oregon State University Corvallis, Oregon, USA
    J Neurovirol 14:389-400. 2008
    ..We have shown that LAT has antiapoptosis activity and demonstrated that the chimeric virus, dLAT-cpIAP, resulting from replacing LAT with the baculovirus antiapoptosis gene cpIAP, has a wild-type HSV-1 ..
  41. ncbi Possible involvement of queuine in regulation of cell proliferation
    Chandramani Pathak
    School of Studies in Biochemistry, Jiwaji University, Gwalior, India
    Biofactors 29:159-73. 2007
    ..For this DLAT cancerous mouse, U87 cell line and HepG2 cell line are treated with different concentrations of queuine and the ..
  42. ncbi Cryptic antigenic determinants on the extracellular pyruvate dehydrogenase complex/mimeotope found in primary biliary cirrhosis. A probe by affinity mass spectrometry
    T T Yip
    Department of Food Science and Technology, Allergy and Clinical Immunology, University of California Davis, School of Medicine, Davis, California 95616, USA
    J Biol Chem 271:32825-33. 1996
    Affinity mass spectrometry (AMS) was used to evaluate the structural diversity of the E2 component of pyruvate dehydrogenase complex (PDC) in normal and diseased liver cells, including those from patients with the autoimmune disease ..
  43. doi Crystal structure of Bacillus cereus D-alanyl carrier protein ligase (DltA) in complex with ATP
    Khan Tanjid Osman
    Department of Biochemistry, University of Saskatchewan, A3 Health Sciences Building, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5
    J Mol Biol 388:345-55. 2009
    ..Disruption of the bacterial dlt operon involved in teichoic acid alanylation, as well as inhibition of the DltA (D-alanyl carrier protein ligase) protein, has been shown to render the bacterium more susceptible to conventional ..
  44. ncbi Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice
    Sabine Oertelt
    Division of Rheumatology, Allergy and Clinical Immunology, University of California School of Medicine, Davis, CA 95616, USA
    J Immunol 177:1655-60. 2006
    Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver, characterized by lymphocytic infiltrates in portal tracts, selective destruction of biliary epithelial cells, and anti-mitochondrial Abs (AMAs)...
  45. doi New ELISA for detecting primary biliary cirrhosis-specific antimitochondrial antibodies
    Cornelia Dähnrich
    EUROIMMUN AG, Lubeck, Germany
    Clin Chem 55:978-85. 2009
    Antimitochondrial antibodies specific for primary biliary cirrhosis (PBC) target the E2 subunits of 2-oxo acid dehydrogenase complexes, in particular the pyruvate dehydrogenase complex (PDC)-E2...
  46. pmc Haemophilus ducreyi Outer membrane determinants, including DsrA, define two clonal populations
    Catherine Dinitra White
    Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Infect Immun 73:2387-99. 2005
    ..expressed variant forms of other outer membrane proteins (OMPs) including NcaA (necessary for collagen adhesion A), DltA (ducreyi lectin A), Hlp (H...
  47. ncbi Salt-induced changes in the subunit structure of the Bacillus stearothermophilus lipoate acetyltransferase
    Yuichi Shigeoka
    Institute of Genetic Resources, Faculty of Agriculture, Kyushu University
    Biosci Biotechnol Biochem 77:1637-44. 2013
    ..PDC, in which PSBD is occupied by other components, and a truncated E2 undergo dissociation only. LD-PSBD region besides CD might then contribute to the partial association of dissociated E2...
  48. pmc DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model
    Christopher Weidenmaier
    Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Department, University of Tubingen, 72076 Tubingen, Germany
    Infect Immun 73:8033-8. 2005
    ..The current study investigated the effects of dltA and mprF mutations on the following host factors relevant to endovascular infections: (i) in vitro susceptibility ..
  49. pmc A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse
    Ling Jin
    Department of Ophthalmology, University of California, Irvine, School of Medicine, 92697, USA
    J Virol 79:12286-95. 2005
    ..Mice were ocularly infected with this mutant, designated dLAT-cpIAP, and the reactivation phenotype was determined using the trigeminal ganglion explant model...
  50. ncbi VirR, a response regulator critical for Listeria monocytogenes virulence
    Pierre Mandin
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, France
    Mol Microbiol 57:1367-80. 2005
    ..monocytogenes virulence. However, a strain lacking dltA, was not as impaired in virulence as the DeltavirR strain, suggesting a role in virulence for other members of the ..
  51. ncbi Effect of D-alanylation of (lipo)teichoic acids of Staphylococcus aureus on host secretory phospholipase A2 action before and after phagocytosis by human neutrophils
    Catherine L Hunt
    The Inflammation Program, University of Iowa and Veterans Affairs Medical Center, Iowa City 52242, USA
    J Immunol 176:4987-94. 2006
    ..However, we show that isogenic wild-type and dltA S. aureus are equally resistant to gV/X PLA2 during phagocytosis and when exposed to the purified enzymes...
  52. ncbi Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic
    Dimitrios Petrou Bogdanos
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Hepatology 42:458-65. 2005
    The serological hallmark of primary biliary cirrhosis (PBC) is the presence of pyruvate dehydrogenase complex E2 subunit (PDC-E2) antimitochondrial antibodies (AMAs)...
  53. ncbi Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis
    Dimitrios Petrou Bogdanos
    Immunology Group, Institute of Hepatology, University College London Medical School and Hospitals, Harold Samuel House, 69 75 Chenies Mews, London WC1E 6HX, UK
    J Hepatol 36:14-21. 2002
    ..coli) are uniquely present in primary biliary cirrhosis (PBC)...
  54. doi Transient elevation of synaptosomal mitoenergetic proteins and Hsp70 early in a rat model of chronic cerebrovascular hypoperfusion
    Hai ning Zhang
    Department of Neurology, The First Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, China
    Neurol Sci 34:471-7. 2013
    ..Our results imply that metabolic reserve and anti-oxidative stress might transiently exist in the early stage of CCH, which probably help cognitive save...
  55. pmc Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
    Hiroto Kita
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, California 95616, USA
    J Clin Invest 109:1231-40. 2002
    While the pathologic mechanisms responsible for organ-specific tissue damage in primary biliary cirrhosis (PBC) remain an enigma, it has been suggested that the pathology is mediated by autoreactive T cells infiltrating the intrahepatic ..
  56. ncbi Clinical significance of positive immunoblotting but negative immunofluorescence for antimitochondrial antibodies in patients with liver diseases other than primary biliary cirrhosis
    Jun Ichi Masuda
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Japan
    Autoimmunity 35:135-41. 2002
    ..AMA), can be detected by immunoblotting in patients with liver diseases other than primary biliary cirrhosis (PBC), who are negative for AMA by conventional indirect immunofluorescence...
  57. ncbi Cloning of murine PDC-E2 gene and generation of PDC-E2 overexpressing cell line: a key step to clarify the pathogenesis of PBC?
    Hiromi Ishibashi
    J Gastroenterol 37:494-5. 2002
  58. ncbi Analysis of TCR antagonism and molecular mimicry of an HLA-A0201-restricted CTL epitope in primary biliary cirrhosis
    Hiroto Kita
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, 95616, USA
    Hepatology 36:918-26. 2002
    Although the etiology and mechanism of primary biliary cirrhosis (PBC) is unknown, growing evidence suggests a major role for T cells...
  59. ncbi Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies
    Patrick S C Leung
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA 95616, USA
    J Immunol 170:5326-32. 2003
    ..complex (PDC-E2) is the major autoantigen recognized by antimitochondrial Abs (AMA) in primary biliary cirrhosis (PBC)...
  60. pmc Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis
    Richy C Y Chen
    Division of Rheumatology Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 57:1498-508. 2013
    ..the E2 subunit of pyruvate dehydrogenase (PDC-E2) are detected in 95% of patients with primary biliary cirrhosis (PBC) and are present before the onset of clinical disease...
  61. pmc Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA
    Patrick S C Leung
    Division of Rheumatology Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    J Autoimmun 41:79-86. 2013
    ..We have addressed this issue and focused on primary biliary cirrhosis (PBC), an autoimmune disease of the liver...
  62. ncbi Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis
    Sylvaine F A Bruggraber
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis Medical School, 95616, USA
    Gastroenterology 125:1705-13. 2003
    ..The immunodominant autoantigen in primary biliary cirrhosis (PBC), E2 components of pyruvate dehydrogenase complexes (PDC-E2), has a lipoate molecule bonded to the domain to which ..
  63. ncbi Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis
    Dimitrios Petrou Bogdanos
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Hepatol 40:31-9. 2004
    Previous studies on patients with primary biliary cirrhosis (PBC) have shown extensive cross-reactivity between the dominant B- and T-cell epitopes of human pyruvate dehydrogenase complex-E2 (PDC-E2), and microbial mimics...
  64. ncbi [The significance of anti-nuclear envelope (gp210) antibody in primary biliary cirrhosis]
    Minoru Nakamura
    Clinical Research Center, NHO Nagasaki Medical Center and Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 28:117-22. 2005
    Primary biliary cirrhosis (PBC) is considered to be an autoimmune disease selectively targeted for interlobular bile ducts...
  65. pmc Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate
    Michael J Emanuele
    Division of Genetics, Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9845-50. 2011
    ..We conclude that PAF15 is an APC/C-regulated protein involved in both cell cycle progression and the DNA damage response...
  66. doi Apotopes and innate immune system: novel players in the primary biliary cirrhosis scenario
    Ana Lleo
    Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, MI, Italy
    Dig Liver Dis 45:630-6. 2013
    ..This review article is intended to provide a critical overview of the role of apoptosis in biliary epithelial cells, the activation of the innate immune system, and its biological and clinical significance in primary biliary cirrhosis. ..
  67. ncbi Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis
    Takashi Kamihira
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3 101 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Gastroenterology 125:1379-87. 2003
    ..characteristics of autoreactive costimulation-independent or CD4+ CD28- T cells in primary biliary cirrhosis (PBC) by taking advantage of the well-defined immunodominant autoepitope of the E2 component of pyruvate dehydrogenase (..
  68. pmc Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis
    Masanobu Tsuda
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 54:1293-302. 2011
    In primary biliary cirrhosis (PBC), patients develop a multilineage response to a highly restricted peptide of the E2 component of pyruvate dehydrogenase (PDC-E2) involving autoantibody and autoreactive cluster of differentiation (CD)4(+)..
  69. pmc Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity
    Phornnop Naiyanetr
    Division of Rheumatology, Allergy, and Clinical Immunology, Department of Internal Medicine, University of California, Davis, CA 95616, USA
    J Autoimmun 37:209-16. 2011
    ..of the pyruvate dehydrogenase complex (PDC-E2), may lead to loss of self-tolerance in primary biliary cirrhosis (PBC)...
  70. doi Molecular characterization of 82 patients with pyruvate dehydrogenase complex deficiency. Structural implications of novel amino acid substitutions in E1 protein
    A Imbard
    Biochimie Hôpital de Bicêtre, Hôpitaux Universitaires Paris Sud, AP HP, Paris, France
    Mol Genet Metab 104:507-16. 2011
    ..cases result from mutations in the X-linked gene for the pyruvate dehydrogenase E1α subunit (PDHA1) while a few cases result from mutations in genes for E1β (PDHB), E2 (DLAT), E3 (DLD) and E3BP (PDHX) subunits or PDH-phosphatase (PDP1).
  71. doi CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis
    Shinji Shimoda
    Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    J Autoimmun 31:110-5. 2008
    Approximately 5% of patients with primary biliary cirrhosis (PBC) lack characteristic anti-mitochondrial antibodies (AMA). Yet clinically AMA+ and AMA- patients are similar...
  72. pmc Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development
    BABACAR CISSE
    Department of Microbiology, Columbia University Medical Center, New York, NY 10032, USA
    Cell 135:37-48. 2008
    ..These results identify E2-2 as a specific transcriptional regulator of the PDC lineage in mice and humans and reveal a key function of E proteins in the innate immune system...
  73. doi Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains
    Huma Yonus
    Institut für Biochemie und Biotechnologie, Martin Luther Universitat Halle Wittenberg, Kurt Mothes Strasse 3, D 06120 Halle Saale, Germany
    J Biol Chem 283:32484-91. 2008
    b>DltA, the D-alanine:D-alanyl carrier protein ligase responsible for the initial step of lipoteichoic acid D-alanylation in Gram-positive bacteria, belongs to the adenylation domain superfamily, which also includes acetyl-CoA synthetase ..
  74. pmc Apotopes and the biliary specificity of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 49:871-9. 2009
    Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2)...
  75. pmc Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis
    Si Jie Wu
    Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Hepatology 53:915-25. 2011
    ..Our laboratory has developed a xenobiotic induced model of primary biliary cirrhosis (PBC) following immunization of mice with 2-octynoic acid coupled to bovine serum albumin (2-OA-BSA), an antigen ..
  76. pmc Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants
    Philong Ta
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0314, USA
    J Bacteriol 193:1981-90. 2011
    ..The reduction of oxidized Ohr by NADH was shown to be catalyzed by lipoamide dehydrogenase and either lipoamide or DlaT (SucB). Since free lipoamide and lipoic acid levels were shown to be undetectable in M...
  77. pmc Auxiliary role for D-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages
    Akiko Shiratsuchi
    Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Immunology 129:268-77. 2010
    ..The genes mutated, dltA and tagO, encoded proteins involved in the synthesis of D-alanylated wall teichoic acid...
  78. pmc The extracytoplasmic function sigma factor SigV plays a key role in the original model of lysozyme resistance and virulence of Enterococcus faecalis
    André Le Jeune
    Laboratoire de Microbiologie de l Environnement EA956 USC INRA 2017, Universite de Caen Basse Normandie, Caen, France
    PLoS ONE 5:e9658. 2010
    ..Lysozyme could act either as a muramidase and/or as a cationic antimicrobial peptide. Like Staphylococcus aureus, E. faecalis is one of the few bacteria that are completely lysozyme resistant...
  79. doi Comparative gene expression of intestinal metabolizing enzymes
    Ho Chul Shin
    Department of Veterinary Pharmacology and Toxicology, Konkuk University, Seoul 143 701, Republic of Korea
    Biopharm Drug Dispos 30:411-21. 2009
    ..predominant expression of glucuronosyltransferases Ugt1a1 and Ugt1a7, sulfotransferase Sult1b1, acetyltransferase Dlat and acyltransferase Dgat1...
  80. doi Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis
    Christoph P Berg
    Department of Internal Medicine I, Medical Clinic, Eberhard Karls University of Tubingen, Tubingen, Germany
    Liver Int 29:797-809. 2009
    In primary biliary cirrhosis (PBC), autoreactivity mainly targets members of the pyruvate dehydrogenase complex (PDC)...
  81. doi Novel germline SDHD deletion associated with an unusual sympathetic head and neck paraganglioma
    Juan Cadinanos
    Instituto de Medicina Oncológica y Molecular de Asturias, Asturias, Spain
    Head Neck 33:1233-40. 2011
    ..PGLs can occur either sporadically or as part of a hereditary syndrome. Sympathetic head and neck PGLs are extremely rare tumors and only a few cases have been reported to date...
  82. doi Primary biliary cirrhosis and autoimmune hepatitis: apotopes and epitopes
    Ana Lleo
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    J Gastroenterol 46:29-38. 2011
    ..in the case of autoimmune hepatitis types 1 and 2, AIH-1, 2) or cholangiocytes (in primary biliary cirrhosis, PBC)...
  83. doi d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells
    Deema Hussein
    Department of Nutrition and Food Sciences, Texas Woman s University, Denton, TX 76204, USA
    Pancreas 38:e124-36. 2009
    ..We evaluated the impact of d-delta-tocotrienol, the most potent vitamin E isomer, on human MIA PaCa-2 and PANC-1 pancreatic carcinoma cells and BxPC-3 pancreatic ductal adenocarcinoma cells...
  84. pmc Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes
    Aditya Venugopal
    Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Cell Host Microbe 9:21-31. 2011
    ..In contrast to Mtb lacking dihydrolipoamide acyltransferase (DlaT), the E2 of PDH and PNR/P, Lpd-deficient Mtb is severely attenuated in wild-type and immunodeficient mice...
  85. doi Antigenically dominant proteins within the human liver mitochondrial proteome identified by monoclonal antibodies
    Yanfang Ju
    Department of Oncology, General Hospital of PLA, Beijing, 100853, China
    Sci China Life Sci 54:16-24. 2011
    ..1 family member A1, carbamoyl phosphate synthetase 1, dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex), enoyl coenzyme A hydratase 1, and hydroxysteroid (11-beta) dehydrogenase 1...
  86. doi Placental gene expression is related to glucose metabolism and fetal cord blood levels of insulin and insulin-like growth factors in intrauterine growth restriction
    Mi Hee Lee
    Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, Republic of Korea
    Early Hum Dev 86:45-50. 2010
    ..of glycolytic enzyme-related genes, including lactate dehydrogenase C (LDHC), dihydrolipoamide S-acetyltransferase (DLAT), 6 phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2 (PFKFB2), oxoglutarate dehydrogenase, phosphorylase, and ..
  87. pmc Infectious agents in the pathogenesis of primary biliary cirrhosis
    Oscar Danilo Ortega-Hernandez
    The Zabludowicz Center for Autoimmune Diseases and Department of Medicine B, Sheba Medical Center, Tel Aviv, Israel
    Dis Markers 29:277-86. 2010
    Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic liver disease which is characterized by the breakdown of self-tolerance to the highly conserved pyruvate dehydrogenase complex, specially the pyruvate dehydrogenase E2 ..
  88. doi Mouse mammary tumor virus in anti-mitochondrial antibody producing mouse models
    Guangzhi Zhang
    Department of Medicine, University of Alberta, AB, Canada
    J Hepatol 55:876-84. 2011
    ..betaretrovirus resembling the mouse mammary tumor virus (MMTV) has been characterized in primary biliary cirrhosis (PBC) and associated with aberrant pyruvate dehydrogenase complex (PDC)-E2-like expression...
  89. pmc Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease
    Kanji Wakabayashi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 48:531-40. 2008
    ..on defining the molecular basis of autoantibody recognition and epitope modification in primary biliary cirrhosis (PBC)...
  90. ncbi Development of an enzyme immune assay for detecting M2 autoantibodies specific for primary biliary cirrhosis
    Xiao hua Jiang
    Department of Laboratory Medicine, 85th Military Hospital, Shanghai 200052, China
    Hepatobiliary Pancreat Dis Int 2:290-4. 2003
    To develope a new enzyme immune assay (ELISA) for detection of M2 antibody specific for primary biliary cirrhosis (PBC) by using a triple hybrid clone as antigen, which coexpresses the three immunodominant lipoyl domains of PDC-E2, ..
  91. ncbi Attenuated virulence of Streptococcus agalactiae deficient in D-alanyl-lipoteichoic acid is due to an increased susceptibility to defensins and phagocytic cells
    Claire Poyart
    Laboratoire Mixte Pasteur Necker de Recherche sur les Streptocoques et Streptococcies, Faculte de Medecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    Mol Microbiol 49:1615-25. 2003
    ..We demonstrate that a DltA- isogenic mutant displays an increased susceptibility to host defence peptides such as human defensins and animal-..
  92. ncbi T cell immunity and primary biliary cirrhosis
    Hiromi Ishibashi
    Clinical Research Center, National Nagasaki Medical Center, Kubara 2 1001 1, Omura, Nagasaki 856 8562, Japan
    Autoimmun Rev 2:19-24. 2003
    T lymphocytes play a pivotal role in the autoimmune response in primary biliary cirrhosis (PBC). Recent studies have shown that there is overlapping in the PDC-E2-specific T and B cell epitopes...
  93. ncbi Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis
    Shuji Matsumura
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, 95616, USA
    Hepatology 36:1125-34. 2002
    ..has implicated the involvement of autoreactive T lymphocytes in the pathogenesis of primary biliary cirrhosis (PBC)...
  94. ncbi Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells
    Liqun Wang
    Department of Gastroenterology and Cancer Gene Regulation, Kanazawa University Graduate School of Medical Sciences, Japan
    J Gastroenterol 37:449-54. 2002
    ..acetyltransferase component (E2) of pyruvate dehydrogenase complex (PDC) and primary biliary cirrhosis (PBC) is clinically established. However, the detailed pathological function of the PDC-E2 gene is as yet unclear...
  95. ncbi Staphylococcus and biofilms
    Friedrich Götz
    Department of Microbial Genetics, Universitat Tubingen, Waldhäuser Str 70 8, D 72076 Tubingen, Germany
    Mol Microbiol 43:1367-78. 2002
    ..characterized mutants are affected in the major autolysin (atlE) and in D-alanine esterification of teichoic acids (dltA)...
  96. pmc Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis
    J A Odin
    Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 108:223-32. 2001
    ..against pyruvate dehydrogenase-E2 (PDC-E2), a ubiquitous mitochondrial protein, and primary biliary cirrhosis (PBC) is unexplained...
  97. pmc Autoantigens in primary biliary cirrhosis
    D E Jones
    Centre for Liver Research, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Clin Pathol 53:813-21. 2000
    The automimmune liver disease primary biliary cirrhosis (PBC) is characterised by serum autoantibodies directed at mitochondrial and nuclear antigens (seen in most patients and a subset of patients, respectively)...
  98. ncbi Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy
    D E Jones
    Centre for Liver Research, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Liver 20:351-6. 2000
    Primary biliary cirrhosis (PBC) is characterised by intra-hepatic immune-mediated cholangiopathy (non-suppurative destructive cholangitis (NSDC))...
  99. ncbi Prediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display
    M J Rowley
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Immunol 164:3413-9. 2000
    Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by autoantibodies reactive with the pyruvate dehydrogenase complex...
  100. ncbi Immunopathology of primary biliary cirrhosis
    R E Joplin
    Liver Research Laboratories, University Hospital Birmingham, UK
    Eur J Gastroenterol Hepatol 11:587-93. 1999
    ....
  101. pmc Regulated expression of the Streptococcus mutans dlt genes correlates with intracellular polysaccharide accumulation
    G A Spatafora
    Department of Biology, Middlebury College, Middlebury, Vermont 05753, USA
    J Bacteriol 181:2363-72. 1999
    ..of these open reading frames (ORF1) revealed domains which are highly conserved among D-alanine-activating enzymes (DltA) in Lactobacillus rhamnosus (formerly Lactobacillus casei) and Bacillus subtilis...

Research Grants62

  1. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
    Approximately 1 in 2,000 women above the age of 50 develop primary biliary cirrhosis (PBC). There is no cure for this progressive hepatobiliary disease, which is one of the major indications for liver transplantation in the US...
  2. FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    ANGELA FOREMAN; Fiscal Year: 2006
    b>PBC is an autoimmune liver disease characterized by obstruction of intrahepatic bile ducts and high titer antimitochondrial autoantibodies (AMA). The predominant autoantigen is PDC-E2...
  3. Dihydrolipoamide Acyltransferase:Target for Chemotherapy
    Carl Nathan; Fiscal Year: 2004
    ..helps to protect the bacillus against oxidative/nitrosative stress: Rv2215 or dihydrolipoamide acyltransferase (DLAT) (formerly "SucB")...
  4. Role of Apoptotic Cholangiocytes in PBC
    JOSEPH ODIN; Fiscal Year: 2005
    ..clinical experience of the past fourteen years have laid the foundation for success in studying the pathogenesis of PBC. The combination of a Ph.D. and M.D...
  5. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL GERSHWIN; Fiscal Year: 2009
    Primary biliary cirrhosis (PBC) is considered a prototypic female predominant autoimmune disease. We have completed the largest case-controlled epidemiological study and have been on the edge in defining the basis of autoreactivity...
  6. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    rimary biliary cirrhosis (PBC) is an enigmatic, liver specific, autoimmune disease characterized by antimito- chondrial antibodies and progressive destruction of intrahepatic bile ducts...
  7. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..among autoimmune serologic reactants because of their extremely high association with primary biliary cirrhosis (PBC)...
  8. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2009
    ..among autoimmune serologic reactants because of their extremely high association with primary biliary cirrhosis (PBC)...
  9. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL E GERSHWIN; Fiscal Year: 2010
    Primary biliary cirrhosis (PBC) is considered a prototypic female predominant autoimmune disease. We have completed the largest case-controlled epidemiological study and have been on the edge in defining the basis of autoreactivity...
  10. dnTGF Beta RII Mice and PBC
    William M Ridgway; Fiscal Year: 2010
    Primary biliary cirrhosis (PBC) is a liver specific autoimmune disease characterized by portal tract lymphocytic infiltration, selective destruction of biliary epithelial cells and antimitochondrial antibodies (AMAs)...
  11. EPIDEMIOLOGY OF PBC: A GENOME-WIDE ASSOCIATION STUDY
    MERRILL GERSHWIN; Fiscal Year: 2007
    Primary biliary cirrhosis (PBC) is considered a prototypic female predominant autoimmune disease. We have completed the largest case-controlled epidemiological study and have been on the edge in defining the basis of autoreactivity...
  12. BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMA
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..It is hoped that findings from these studies will evolve relatively non-toxic therapeutic alternatives for attenuating bronchial hyperresponsiveness and inflammation in patients with asthma. ..
  13. EPIDEMIOLOGY OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2004
    Primary biliary cirrhosis (PBC) is an enigmatic autoimmune disease characterized by female predominance, high titer anti- mitochondrial antibodies (AMA), small bile duct destruction, and liver failure...
  14. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2006
    The etiology of primary biliary cirrhosis (PBC) remains enigmatic despite significant advances in our understanding of the nature of the autoantigens and of the immune response...
  15. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2007
    b>PBC is an autoimmune liver disease characterized by intrahepatic bile duct obstruction and antimitochondrial autoantibodies (AMAs)...
  16. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2007
    Primary biliary cirrhosis (PBC) is an enigmatic, liver specific, autoimmune disease characterized by antimitochondrial antibodies and progressive destruction of intrahepatic bile ducts...