DJ 1

Summary

Gene Symbol: DJ 1
Description: Parkinsonism associated deglycase
Alias: DJ-1, DJ1, GATD2, HEL-S-67p, protein DJ-1, protein deglycase DJ-1, Parkinson disease (autosomal recessive, early onset) 7, epididymis secretory sperm binding protein Li 67p, oncogene DJ1, parkinson protein 7
Species: human

Top Publications

  1. pmc DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
    Shoshana Shendelman
    Department of Pathology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    PLoS Biol 2:e362. 2004
  2. pmc Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
    Frits Kamp
    DZNE German Center for Neurodegenerative Diseases, Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, Munich, Germany
    EMBO J 29:3571-89. 2010
  3. doi DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection
    Zhiquan Wang
    Laboratory of Neurodegenerative Diseases, Institute of Health Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Science and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Ann Neurol 70:591-9. 2011
  4. pmc Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 87:123-9. 2009
  5. pmc Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 102:9691-6. 2005
  6. doi DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA
    Xiangyi He
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Carcinogenesis 33:555-62. 2012
  7. pmc Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Neurochem 121:830-9. 2012
  8. doi Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation
    Nan Zhong
    Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Mol Genet 17:3357-67. 2008
  9. doi TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains
    Silvia Zucchelli
    Sector of Neurobiology, International School for Advanced Studies SISSA, Area Science Park, S S 14, Km 163 5, Basovizza, 34012 Trieste, Italy
    Hum Mol Genet 19:3759-70. 2010
  10. pmc DJ-1 has a role in antioxidative stress to prevent cell death
    Takahiro Taira
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Sapporo 060 0812, Japan
    EMBO Rep 5:213-8. 2004

Research Grants

Detail Information

Publications240 found, 100 shown here

  1. pmc DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
    Shoshana Shendelman
    Department of Pathology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    PLoS Biol 2:e362. 2004
    ..We further demonstrate that DJ-1 chaperone activity in vivo extends to alpha-synuclein, a protein implicated in PD pathogenesis...
  2. pmc Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
    Frits Kamp
    DZNE German Center for Neurodegenerative Diseases, Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, Munich, Germany
    EMBO J 29:3571-89. 2010
    ..Finally, mitochondrial fragmentation induced by expression of αS is rescued by coexpression of PINK1, parkin or DJ-1 but not the PD-associated mutations PINK1 G309D and parkin Δ1-79 or by DJ-1 C106A...
  3. doi DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection
    Zhiquan Wang
    Laboratory of Neurodegenerative Diseases, Institute of Health Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Science and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Ann Neurol 70:591-9. 2011
    ..However, the mechanisms underlying dopaminergic neuron loss related to DJ-1 mutation remain undefined. Therefore, it is important to find the new mechanisms underlying the antioxidative functions of DJ-1...
  4. pmc Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 87:123-9. 2009
    ..These findings further highlight the multifaceted functions of DJ-1 as a cytoprotector in different cellular compartments...
  5. pmc Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
    Eunsung Junn
    Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 102:9691-6. 2005
    ..These findings suggest that the regulated sequestration of Daxx in the nucleus and keeping apoptosis signal-regulating kinase 1 activation in check is a critical mechanism by which DJ-1 exerts its cytoprotective function...
  6. doi DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA
    Xiangyi He
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Carcinogenesis 33:555-62. 2012
    ..These data represent the first identification of an important function of DJ-1, which is to regulate the invasion and metastasis properties of PDAC through the ERK/uPA cascade...
  7. pmc Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Neurochem 121:830-9. 2012
    ..Taken together, these studies suggest that DJ-1 is involved in the regulation of mitochondrial dynamics through modulation of DLP1 expression and PD-associated DJ-1 mutations may cause PD by impairing mitochondrial dynamics and function...
  8. doi Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation
    Nan Zhong
    Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Mol Genet 17:3357-67. 2008
    ..Consequent abnormal mitochondrial gene expression may contribute to the development of sporadic PD...
  9. doi TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains
    Silvia Zucchelli
    Sector of Neurobiology, International School for Advanced Studies SISSA, Area Science Park, S S 14, Km 163 5, Basovizza, 34012 Trieste, Italy
    Hum Mol Genet 19:3759-70. 2010
    ..In human post-mortem brains of PD patients, TRAF6 protein colocalizes with aSYN in LBs. These results reveal a novel role for TRAF6 and for atypical ubiquitination in PD pathogenesis...
  10. pmc DJ-1 has a role in antioxidative stress to prevent cell death
    Takahiro Taira
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Sapporo 060 0812, Japan
    EMBO Rep 5:213-8. 2004
    ..These results clearly showed that DJ-1 has a role in the antioxidative stress reaction and that mutations of DJ-1 lead to cell death, which is observed in PD...
  11. pmc DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
    R Sean McNally
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 286:4098-106. 2011
    ....
  12. ncbi DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras
    D Nagakubo
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Biophys Res Commun 231:509-13. 1997
    ..Moreover, DJ-1 translocated from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway...
  13. doi YajL, the prokaryotic homolog of the Parkinsonism-associated protein DJ-1, protects cells against protein sulfenylation
    Valerie Gautier
    Stress Molecules, Institut Jacques Monod, Universite Paris 7, 15 Rue Hélène Brion, 75013 Paris, France
    J Mol Biol 421:662-70. 2012
    ....
  14. pmc Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1
    M Emdadul Haque
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 287:23162-70. 2012
    ....
  15. doi DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats
    Shuang Yong Sun
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China
    Brain Res Bull 88:609-16. 2012
    ..Therefore, DJ-1 protein protected dopaminergic neurons in two PD model rats by increasing antioxidant capacity and inhibiting α-synuclein expression...
  16. doi DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease
    Muhammad U Sajjad
    Neuroscience Group, Centre for Biological Sciences, University of Southampton, Basset Crescent East, Southampton, UK
    Hum Mol Genet 23:755-66. 2014
    ..Our findings clearly establish DJ-1 as a potential therapeutic target for HD and provide the basis for further studies into the role of DJ-1 in protein misfolding diseases. ..
  17. doi Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease
    Fang Liu
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907 2091, USA
    J Neurochem 105:2435-53. 2008
    ..Our findings suggest that DJ-1 acts as a versatile pro-survival factor in dopaminergic neurons, activating different protective mechanisms in response to a diverse range of PD-related insults...
  18. pmc BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity
    Sebastian Deeg
    Department for Neurology, Georg August University Gottingen, 37073 Gottingen, Germany
    J Cell Biol 188:505-13. 2010
    ....
  19. pmc DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
    Casey M Clements
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Proc Natl Acad Sci U S A 103:15091-6. 2006
    ..Furthermore, this DJ-1/Nrf2 functional axis presents a therapeutic target in cancer treatment and justifies DJ-1 as a tumor biomarker...
  20. doi Expression and role of DJ-1 in leukemia
    Hang Liu
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, China
    Biochem Biophys Res Commun 375:477-83. 2008
    ..Thus, DJ-1 might be involved in leukemogesis through regulating cell growth, proliferation, and apoptosis. It could be a potential therapeutic target for leukemia...
  21. ncbi DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy
    Shizuyo Koide-Yoshida
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 8589, Japan
    Int J Mol Med 19:885-93. 2007
    ..These results suggest that oxidative stress to cells abrogates secretion of DJ-1 and that secreted DJ-1 degrades aggregated TTR to protect against the onset of FAP...
  22. doi DJ-1 protects against dopamine toxicity
    Nirit Lev
    Department of Neurology, Felsenstein Medical Research Centre, Rabin Medical Centre, Tel Aviv University, Petah Tikva, Israel
    J Neural Transm (Vienna) 116:151-60. 2009
    ..This mechanism elucidates how mutations in DJ-1 prompt PD and imply that modulation of DJ-1 may serve as a novel neuroprotective modality...
  23. ncbi DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex
    Takeshi Niki
    Graduate School of Pharmaceutical Sciences and College of Medical Technology, Hokkaido University, Kita ku, Sapporo, Japan
    Mol Cancer Res 1:247-61. 2003
    ..These results suggest that AR is positively regulated by DJ-1, which antagonizes the function of negative regulators, including DJBP...
  24. ncbi DJ-1, a novel regulator of the tumor suppressor PTEN
    Raymond H Kim
    Advanced Medical Discovery Institute, The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada M5G 2C1
    Cancer Cell 7:263-73. 2005
    ..DJ-1 is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer...
  25. pmc Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36
    C M van Duijn
    Genetic Epidemiologic Unit, Departments of Epidemiology and Biostatistics and Clinical Genetics, Erasmus Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
    Am J Hum Genet 69:629-34. 2001
    ..Therefore, we conclude that we have identified on chromosome 1 a second locus, PARK7, involved in autosomal recessive, early-onset parkinsonism...
  26. ncbi DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor
    K Takahashi
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    J Biol Chem 276:37556-63. 2001
    ..These results indicate that DJ-1 is a positive regulator of the androgen receptor...
  27. ncbi Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1
    Karin Görner
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 279:6943-51. 2004
    ..Thus, structural defects of [E64D]DJ-1 only become apparent upon denaturing conditions, whereas the L166P mutation causes a drastic defect that leads to excessive degradation...
  28. doi DJ-1 binds to mitochondrial complex I and maintains its activity
    Takuya Hayashi
    Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Biochem Biophys Res Commun 390:667-72. 2009
    ..These findings suggest that DJ-1 is an integral mitochondrial protein and that DJ-1 plays a role in maintenance of mitochondrial complex I activity...
  29. ncbi Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter
    T Taira
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Gene 263:285-92. 2001
    ....
  30. ncbi Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain
    Sun Joo Lee
    Beamline Division, Pohang Accelerator Laboratory, Pohang, 790 784, Kyungbuk, Republic of Korea
    J Biol Chem 278:44552-9. 2003
    ..On the basis of the chaperone activity the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed...
  31. ncbi Immunocytochemical localization of DJ-1 in human male reproductive tissue
    Kaoru Yoshida
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi, Saitama, Japan
    Mol Reprod Dev 66:391-7. 2003
    ..It is suggested that DJ-1 may play an important and as yet uncharacterized role in spermatogenesis and fertilization in humans...
  32. ncbi DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia
    Patrizia Rizzu
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 55:113-8. 2004
    ..Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1...
  33. ncbi DJ-1 interacts with HIPK1 and affects H2O2-induced cell death
    Aya Sekito
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060 0812, Japan
    Free Radic Res 40:155-65. 2006
    ....
  34. ncbi Proteomic identification of down-regulation of oncoprotein DJ-1 and proteasome activator subunit 1 in hepatitis B virus-infected well-differentiated hepatocellular carcinoma
    Daohai Zhang
    Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore
    Int J Oncol 31:577-84. 2007
    ..These findings elucidate, at least in part, the molecular events underlying the mechanism and the potential roles of DJ-1 and PA28alpha in the onset of hepatocarcinogenesis...
  35. ncbi Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Montebello, N 0310 Oslo, Norway
    Hum Pathol 39:87-95. 2008
    ..In contrast, PTEN expression is infrequent in this disease. These findings may provide one of the molecular mechanisms that mediate cancer cell survival and aggressiveness in this tumor...
  36. ncbi DJ-1 decreases Bax expression through repressing p53 transcriptional activity
    Jun Fan
    Laboratory of Molecular Neuropathology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Biol Chem 283:4022-30. 2008
    ..Our data provide evidence that the protective effects of DJ-1 on apoptosis are associated with its ability of decreasing Bax level through inhibiting p53 transcriptional activity...
  37. doi DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age
    Steven J Mullett
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropathology 29:125-31. 2009
    ..Our data support the conclusion that the major cellular DJ-1 response to stroke in the human brain is astrocytic, and that there is a temporal correlation between DJ-1 expression in these cells and advanced infarct age...
  38. doi DJ-1 expression in glioblastomas shows positive correlation with p53 expression and negative correlation with epidermal growth factor receptor amplification
    David A Hinkle
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    Neuropathology 31:29-37. 2011
    ....
  39. pmc Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione
    Akiko Miyama
    Department of Medical Life Systems, Faculty of Medical and Life Sciences, Doshisha University, Tatara, Kyotanabe, Kyoto, Japan
    PLoS ONE 6:e27883. 2011
    ..Collectively, these results suggest that electrophilic p-quinone formed from 6-OHDA induces DJ-1 oxidation by decreasing intracellular GSH...
  40. doi Regulation of the VHL/HIF-1 pathway by DJ-1
    Mohammad Parsanejad
    Department of Cellular and Molecular Medicine
    J Neurosci 34:8043-50. 2014
    ..Together, our findings delineate a model by which DJ-1 mediates neuronal survival by regulation of the VHL-HIF-1α pathway. ..
  41. ncbi Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8519, Tokyo, Japan
    Biochem Biophys Res Commun 312:1342-8. 2003
    ..These results suggest that loss of protective activity of DJ-1 from neuro-toxicity induced by these stresses contributes to neuronal cell death in AR-EOP with mutant DJ-1...
  42. ncbi The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
    Rina Bandopadhyay
    Reta Lila Weston Institute of Neurological Studies, Royal Free and UCL Medical School, 46 Cleveland Street, London W1T 4JF, UK
    Brain 127:420-30. 2004
    ..These results are consistent with the hypothesis that neuronal-glial interactions are important in the pathophysiology of Parkinson's disease...
  43. ncbi DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3
    Yumi Shinbo
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Int J Oncol 26:641-8. 2005
    ..These findings suggest that DJ-1 positively regulates p53 through Topors-mediated sumoylation...
  44. pmc Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:10816-24. 2006
    ..Our study provides new insights into the oxidative modifications of DJ-1 and indicates association of oxidative damage to DJ-1 with sporadic PD and AD...
  45. ncbi Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    Vincenzo Bonifati
    Genetic Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
    Science 299:256-9. 2003
    ..Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease...
  46. ncbi Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities
    Y Shinbo
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Cell Death Differ 13:96-108. 2006
    ..Both L166P-expressing cells and DJ-1-knockdown cells were found to be highly susceptible to UV-induced cell apoptosis...
  47. ncbi L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system
    David W Miller
    Laboratory of Neurogenetics, NIA, National Institutes of Health, Bethesda, Maryland 20892 1589, USA
    J Biol Chem 278:36588-95. 2003
    ..These observations are reminiscent of other recessive gene mutations that produce an effective loss of function. The L166P mutation has the simple effect of promoting DJ-1 degradation, thereby reducing net DJ-1 protein within the cell...
  48. ncbi DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells
    J Erin Tillman
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2765, USA
    Cancer Res 67:4630-7. 2007
    ..These data provide a novel mechanism where DJ-1-mediated regulation of AR may promote the progression of prostate cancer to androgen independence...
  49. ncbi Silencing DJ-1 reveals its contribution in paraquat-induced autophagy
    Rosa González-Polo
    CIBER sobre Enfermedades Neurodegenerativas CIBERNED, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y Terapia Ocupacional, Universidad de Extremadura, Caceres, Spain
    J Neurochem 109:889-98. 2009
    ....
  50. ncbi The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease
    Kazuya Honbou
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 12, W 6, Kita ku, Sapporo, 060 0812, Japan
    J Biol Chem 278:31380-4. 2003
    ..DJ-1 may induce conformational changes to acquire catalytic activity in response to oxidative stress...
  51. ncbi Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
    James A Olzmann
    Departments of Pharmacology, Biochemistry, and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 279:8506-15. 2004
    ..Together these findings provide insights into the molecular mechanism by which loss-of-function mutations in DJ-1 lead to Parkinson's disease...
  52. ncbi LRRK2 gene in Parkinson disease: mutation analysis and case control association study
    C Paisan-Ruiz
    National Institute on Aging, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, MD, USA
    Neurology 65:696-700. 2005
    ....
  53. ncbi DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor
    Nan Zhong
    Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Biol Chem 281:20940-8. 2006
    ..Therefore, our results suggest DJ-1 as a regulator of protein sumoylation and directly link the loss of DJ-1 expression and transcriptional dysfunction to impaired dopamine synthesis...
  54. ncbi Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease
    Vincenzo Bonifati
    Department of Clinical Genetics, Erasmus MC Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Mol Med (Berl) 82:163-74. 2004
    ..Although much work remains to be done to clarify the biology of DJ-1, its proposed activity as a molecular chaperone and/or as oxidative sensor appear intriguing in the light of the current theories on the pathogenesis of PD...
  55. ncbi [DJ-1 expression in laryngeal squamous cell carcinoma and its relationship with tumor recurrence and metastasis]
    Xiao Lin Zhu
    Otorhinolaryngology Hospital of First Affiliated Hospital of SUN Yat sen University, Otorhinolaryngology Institute of Sun Yat sen University, Guangzhou 510080, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 45:497-501. 2010
    ..To detect the expression of DJ-1 in laryngeal squamous cell carcinoma (LSCC) and to study the relationship between DJ-1 expression and clinical indexes of LSCC...
  56. doi The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma
    Raviprakash T Sitaram
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Int J Cancer 125:783-90. 2009
    ..Neither DJ-1, cMyc nor hTERT mRNA levels were associated with proliferation (S-phase fraction), telomere length or prognosis in ccRCC...
  57. ncbi Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease
    Xiao Tao
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Biol Chem 278:31372-9. 2003
    ..The DJ-1 proteins may function only as dimers. The Lys to Arg mutation at residue 130, the site of sumoylation of DJ-1, has minimal impact on the structure of the protein...
  58. pmc The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease
    Mark A Wilson
    Department of Biochemistry and Chemistry and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, MS 029, Waltham, MA 02454 9110, USA
    Proc Natl Acad Sci U S A 100:9256-61. 2003
    ..Taken together, the crystal structure of human DJ-1 plus other observations suggest the possible involvement of this protein in the cellular oxidative stress response and a general etiology of neurodegenerative diseases...
  59. ncbi A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization
    Darren J Moore
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 87:1558-67. 2003
    ..These properties of the L166P mutation may contribute to the loss of normal DJ-1 function and are likely to be the underlying cause of early onset PD in affected members of the Italian kindred...
  60. ncbi DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease
    K Hedrich
    Department of Human Genetics, University of Lubeck, Germany
    Neurology 62:389-94. 2004
    ..DJ-1 (PARK7) was recently reported as a second gene associated with recessively inherited PD with a homozygous exon deletion and a homozygous point mutation in two families...
  61. ncbi Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations
    Lorraine N Clark
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York, USA
    Mov Disord 19:796-800. 2004
    ..Mutations in the DJ-1 gene are rare in EOPD in both sporadic and familial cases...
  62. ncbi Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)
    Robert Hering
    Department of Medical Genetics, University of Tubingen, Tubingen, Germany
    Hum Mutat 24:321-9. 2004
    ..Recently, two mutations in the DJ1 gene were described as a second cause of autosomal recessive EOPD (PARK7)...
  63. ncbi Causes of Parkinson's disease: genetics of DJ-1
    Patrick M Abou-Sleiman
    Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Cell Tissue Res 318:185-8. 2004
    ..It therefore remains to be determined whether these patients form Lewy bodies and/or Lewy neurites, the eosinophilic fibrillary inclusions that contain predominantly alpha-synuclein and that are the pathological hallmark of PD...
  64. ncbi A deletion in DJ-1 and the risk of dementia--a population-based survey
    Alejandro Arias Vasquez
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurosci Lett 372:196-9. 2004
    ..All subjects were heterozygous for the deletion and related to a common ancestor within eight generations. Our results suggest it is unlikely that haploinsufficiency in the DJ-1 gene imparts an increased risk for dementia...
  65. ncbi PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism
    Christine Klein
    Department of Neurology, University of Lubeck, Lubeck, Germany
    Eur J Hum Genet 13:1086-93. 2005
    ..No mutations were found in the DJ-1 gene. The number of mutation carriers in both the Parkin and the PINK1 gene in our cohort is low but comparable, suggesting that PINK1 has to be considered in EOP...
  66. ncbi DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex
    Grazia Annesi
    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy
    Ann Neurol 58:803-7. 2005
    ..Both mutations cosegregated with the disease and were detected in a heterozygous state in the patients' mother and their healthy siblings. Our findings expand the spectrum of clinical presentations associated with mutations in DJ-1 gene...
  67. ncbi The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein
    Wenbo Zhou
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    J Mol Biol 356:1036-48. 2006
    ....
  68. ncbi Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
    Beisha Tang
    National Laboratory of Medical Genetics, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China
    Hum Mol Genet 15:1816-25. 2006
    ..This study reports the first case of autosomal recessive PD with digenic inheritance and demonstrates that DJ-1 and PINK1 physically associate and collaborate to protect cells against stress via complex formation...
  69. pmc Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease
    James A Olzmann
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 500:585-99. 2007
    ..Together, these findings indicate neuronal and synaptic expression of DJ-1 in primate subcortical brain regions and suggest a physiological role for DJ-1 in the survival and/or function of nigral-striatal neurons...
  70. pmc DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70
    Sara Batelli
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    PLoS ONE 3:e1884. 2008
    ..DJ-1 (PARK7), another family-PD-linked gene causing an autosomal recessive form of the pathology, shows antioxidant and chaperone-like activities too...
  71. doi Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease
    Jung Mi Choi
    Department of Neurology, Hallym University Sacred Heart Hospital, Ilsong Institute of Life Science, Hallym University, Dongan Gu, Anyang si, Gyeonggi Do, Korea
    Neurogenetics 9:263-9. 2008
    ..We identified genetic variants in PARKIN, PINK1, LRRK2, and SNCA as a cause or genetic risk factors for PD in 25% of Korean EOPD, and mutation of PARKIN was the most common genetic cause...
  72. doi Compound heterozygosity in DJ-1 gene non-coding portion related to parkinsonism
    Patrizia Tarantino
    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy
    Parkinsonism Relat Disord 15:324-6. 2009
    ..Our results support the growing importance of mutations in non-coding portion of human genome, and confirm that alterations in DJ-1 are a cause, even if rare, of early-onset Parkinson's disease...
  73. doi Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population
    Karen Nuytemans
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium
    Hum Mutat 30:1054-61. 2009
    ..Furthermore, though mutations is SNCA, PINK1, and PARK7 are rare, our identification of a SNCA duplication confirmed that screening of these genes remains meaningful...
  74. ncbi Pathways to Parkinsonism
    Mark R Cookson
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 37:7-10. 2003
    ..The identification of multiple genetic causes will provide further impetus to describe the pathway leading to PD...
  75. ncbi Crystal structure of DJ-1/RS and implication on familial Parkinson's disease
    Qing Huai
    Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC 27599 7260, USA
    FEBS Lett 549:171-5. 2003
    ..As a result, the conformational changes may diminish the DJ-1 binding with its partner, leading to the familial Parkinson's disease caused by the single L166P mutation...
  76. ncbi The role of pathogenic DJ-1 mutations in Parkinson's disease
    Patrick M Abou-Sleiman
    Department of Molecular Neuroscience, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Ann Neurol 54:283-6. 2003
    ..No mutations were found in our cohort of later onset sporadic pathologically confirmed cases, suggesting that DJ-1 mutations may only rarely contribute to the cause of this more typical sporadic form of the disease...
  77. ncbi Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD
    J Eerola
    Department of Neurology, Helsinki University Central Hospital and University of Helsinki, Biomedicum Helsinki, Neuroscience Programme, Finland
    Neurology 61:1000-2. 2003
    ..168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic PD in a Finnish case-control series. This gene does not play a major role in the genetic predisposition to PD in this population...
  78. ncbi DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism
    V Bonifati
    Department of Clinical Genetics, Erasmus Medical Center Rotterdam, 1738 DR Rotterdam, The Netherlands
    Neurol Sci 24:159-60. 2003
    ..Elucidating the role of DJ-1 will lead to a better understanding of the pathogenesis of DJ-1-related and common forms of Parkinson's disease...
  79. ncbi Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease
    Christopher M Morris
    MRC Building, Institute for the Health of the Elderly, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Neurosci Lett 352:151-3. 2003
    ..The DJ-1 gene does not appear to be a significant risk factor for late onset Lewy body disease in this population...
  80. ncbi The R98Q variation in DJ-1 represents a rare polymorphism
    Katja Hedrich
    Ann Neurol 55:145; author reply 145-6. 2004
  81. pmc The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
    Rosa M Canet-Aviles
    Laboratory of Neurogenetics, National Institute on Aging, 9000 Rockville Pike, Bethesda, MD 20892 1589, USA
    Proc Natl Acad Sci U S A 101:9103-8. 2004
    ..We suggest that DJ-1 protects against neuronal death, and that this is signaled by acidification of the key cysteine residue, C106...
  82. ncbi Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients
    Kazuko Takahashi-Niki
    CREST, Japan Science and Technology Corporation, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    Biochem Biophys Res Commun 320:389-97. 2004
    ..These cell lines also showed that all of the mutants had reduced activities to eliminate exogenously added H2O2 and that these activities, except for that of D149A, were parallel to those preventing H2O2-induced cell death...
  83. ncbi Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress
    Darren J Moore
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 14:71-84. 2005
    ..These data potentially link DJ-1 and parkin in a common molecular pathway at multiple levels that may have important implications for understanding the pathogenesis of inherited and sporadic PD...
  84. ncbi The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
    Jin Xu
    Department of Neurology, Caritas St Elizabeth s Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Mol Genet 14:1231-41. 2005
    ..Mutations that impair the transcriptional co-activator function of DJ-1 render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of PD...
  85. ncbi Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
    Li Zhang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 14:2063-73. 2005
    ..Our findings of DJ-1's mitochondrial localization may have important implications for understanding the pathogenesis of PD...
  86. ncbi DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
    Wenbo Zhou
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:43150-8. 2005
    ..We conclude that DJ-1 has multiple specific mechanisms for protecting dopamine neurons from cell death...
  87. ncbi Establishment of specific antibodies that recognize C106-oxidized DJ-1
    Hiromasa Ooe
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Neurosci Lett 404:166-9. 2006
    ..These antibodies were found by Western blot analysis to recognize DJ-1 specifically oxidized at C106 but not at other cysteines. These antibodies should be useful to study pathophysiologies of PD and AD...
  88. ncbi Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1
    Karin Görner
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Ludwig Maximilians University of Munich, 80336 Munich, Germany
    J Biol Chem 282:13680-91. 2007
    ....
  89. ncbi On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson Disease. A combined computational and in vitro study
    Fernando E Herrera
    International School for Advanced Studies, INFM DEMOCRITOS, SISSA Unit, Italian Institute of Technology, Via Beirut 2 4, 34014 Trieste, Italy
    J Biol Chem 282:24905-14. 2007
    ..Our combined computational and experimental approach is next used to identify a mutant (R28A) that, in contrast to L166P, destabilizes the dimer subunit-subunit interface without significantly changing secondary structure elements...
  90. pmc Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
    James A Olzmann
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 178:1025-38. 2007
    ....
  91. pmc Structural effects of Parkinson's disease linked DJ-1 mutations
    Gaetano Malgieri
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, New York 10021, USA
    Protein Sci 17:855-68. 2008
    ..The observed structural and thermodynamic differences are likely to underlie any functional variations between these mutants and the wild type, which in turn are likely responsible for the pathogenicity of these mutations...
  92. doi Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia
    George D Mellick
    Eskitis Institute for Cellular and Molecular Therapies, Griffith University, Nathan, QLD 4111, Australia
    Parkinsonism Relat Disord 15:105-9. 2009
    ..G2019S mutation in LRRK2. No alpha-synuclein or DJ-1 variants were observed. Our data suggest that approximately 7% of early-onset PD cases seen in Queensland movement disorders clinics have mutations involving known PARK genes...
  93. pmc Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1
    Deepti Malhotra
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room E7624, 615 North Wolfe St, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 178:592-604. 2008
    ..NRF2, a redox-sensitive transcription factor, dissociates from its inhibitor, KEAP1, to induce antioxidant expression that inhibits oxidative stress...
  94. pmc Cysteine pKa depression by a protonated glutamic acid in human DJ-1
    Anna C Witt
    Department of Biochemistry and Redox Biology Center, The University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    Biochemistry 47:7430-40. 2008
    ..Lastly, a search of the Protein Data Bank (PDB) produces several candidate hydrogen-bonded aspartic/glutamic acid-cysteine interactions, which we propose are particularly common in the DJ-1 superfamily...
  95. pmc Molecular basis for the structural instability of human DJ-1 induced by the L166P mutation associated with Parkinson's disease
    Peter C Anderson
    Biomedical and Health Informatics Program, University of Washington, Box 355013, Seattle, Washington 98195 5013, USA
    Biochemistry 47:9380-93. 2008
    ..These simulations provide details about specific structural disturbances throughout L166P DJ-1 that previous studies have not revealed...
  96. doi Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism
    Ji Feng Guo
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People s Republic of China
    Mov Disord 23:2074-9. 2008
    ..Mutations of DJ-1 and PINK1 gene are also found in Chinese families with AREP. Mutations in ATP13A2 gene may be rare in Chinese families with AREP...
  97. pmc The E163K DJ-1 mutant shows specific antioxidant deficiency
    Chenere P Ramsey
    Department of Pharmacology, University of Pennsylvania School of Medicine, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Brain Res 1239:1-11. 2008
    ..These findings suggest that DJ-1 influences several neuroprotective pathways and that the E163K mutation impairs the mechanism that is more specific to oxidative stress...
  98. doi Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease
    Maria G Macedo
    Section of Medical Genomics, Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
    Mov Disord 24:196-203. 2009
    ..The low overall mutation frequency indicates that the extrapolation of mutation frequencies from other populations should be applied with caution...
  99. doi Genotype-phenotype correlates in Taiwanese patients with early-onset recessive Parkinsonism
    Ming Jen Lee
    Department of Medical Genetics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Mov Disord 24:104-8. 2009
    ..Although the role of heterozygosity of recessive genes in EOP remains to be resolved, molecular analysis and functional imaging will play a decisive role in differential diagnosis and determined therapeutic strategy...
  100. doi DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma
    Hiu Fung Yuen
    Department of Pathology, Queen Mary Hospital, Hong Kong, People s Republic of China
    Cancer Epidemiol Biomarkers Prev 17:3593-602. 2008
    ..003) and DJ-1 (P = 0.034) are independent predictors of patient survival. In conclusion, our results suggest that DJ-1 plays a very important role in transformation and progression of ESCC and may be used as a prognostic marker in ESCC...
  101. pmc Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1
    Jeff Blackinton
    Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, NIA, National Institutes of Health, Bethesda, Maryland 20892 3707, USA
    J Biol Chem 284:6476-85. 2009
    ..We therefore conclude that formation of Cys106-sulfinic acid is a key modification that regulates the protective function of DJ-1...

Research Grants6

  1. Molecular Regulation of Alpha-Synuclein Misfolding and Toxicity in Two Yeast Mode
    SHUBHIK DEBBURMAN; Fiscal Year: 2009
    ..compromised for major cytoplasmic antioxidant enzymes, including catalases, glutathione regulating enzymes, and DJ1, using single knockout strains, and multiple knockouts, where available...
  2. Peter T Nelson; Fiscal Year: 2014
    ..The primary cel culture system will offer an experimental paradigm for testing novel methods of attenuating the dimorphic expression of miR-497 that drives alpha-SN expression. ..
  3. Measuring and Predicting Responses to ATX and MPH
    Mark Stein; Fiscal Year: 2009
    ..A plethora of scientific data documents the robust efficacy [dj1]and safety of psycho stimulants for the management of ADHD symptoms and associated impairments...
  4. Predicting Response to Atomoxetine and Methlyphenidate
    Jeffrey Newcorn; Fiscal Year: 2009
    ..A plethora of scientific data documents the robust efficacy [dj1]and safety of psycho stimulants for the management of ADHD symptoms and associated impairments...
  5. Metal Ion is Critical in amyloid beta Induced JNK Activation
    Xiongwei Zhu; Fiscal Year: 2009
    ..Aim 3: Determine the effect of metal ion chelation on Ab-induced JNK activation. Aim 4: Determine whether H2O2 mediates metal-augmented AB-induced JNK activation. ..
  6. Beta-glucocerebrosidase Mutations and PD in the Ashkenazim
    Lorraine Clark; Fiscal Year: 2006
    ..Significantly, recent studies suggest that mutations in the GBA gene may be associated with Parkinson's disease and the lysosomal/autophagic pathway has also been implicated in PD pathogenesis. [unreadable] [unreadable]..