Gene Symbol: DISP1
Description: dispatched RND transporter family member 1
Alias: DISPA, protein dispatched homolog 1, dispatched A
Species: human
Products:     DISP1

Top Publications

  1. Beaumont M, Akloul L, Carre W, Quelin C, Journel H, Pasquier L, et al. Targeted panel sequencing establishes the implication of planar cell polarity pathway and involves new candidate genes in neural tube defect disorders. Hum Genet. 2019;138:363-374 pubmed publisher
    ..Our study also reveals variants in novel genes such as FREM2 and DISP1. Altogether, these results confirm the implication of the PCP genes and involve the FRAS/FREM2 complex and Sonic ..
  2. Blumberg N, Lebel E, Merin O, Levy G, Bar On E. Skeletal injuries sustained during the Haiti earthquake of 2010: a radiographic analysis of the casualties admitted to the Israel Defense Forces field hospital. Eur J Trauma Emerg Surg. 2013;39:117-22 pubmed publisher
    ..Following the January 12, 2010, earthquake, the State of Israel dispatched a field hospital to Haiti, managing 1,111 patients from January 17, 2010, to January 26, 2010...
  3. Burke R, Nellen D, Bellotto M, Hafen E, Senti K, Dickson B, et al. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell. 1999;99:803-15 pubmed
    ..Despite their opposite roles, Disp and Ptc share structural homology in the form of a sterol-sensing domain, suggesting that release and sequestration of cholesterol-modified Hh may be based on related molecular pathways. ..
  4. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser M, et al. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proc Natl Acad Sci U S A. 2015;112:15372-7 pubmed publisher
  5. Ma Y, Erkner A, Gong R, Yao S, Taipale J, Basler K, et al. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell. 2002;111:63-75 pubmed
    ..This activity is disrupted by alteration of residues functionally conserved in Patched and in a related family of bacterial transmembrane transporters, thus suggesting similar mechanisms of action for all of these proteins. ..
  6. Katoh Y, Katoh M. Hedgehog signaling pathway and gastric cancer. Cancer Biol Ther. 2005;4:1050-4 pubmed
    ..Human SHH, IHH, DHH (Hedgehog homologs), HHAT (Hedgehog acyltransferase), HHIP (Hedgehog-interacting protein), DISP1, DISP2, DISP3 (Dispatched homologs), PTCH1, PTCH2 (Patched homologs), SMO (Smoothened homolog), KIF27, KIF7 (..
  7. Roessler E, Ma Y, Ouspenskaia M, Lacbawan F, Bendavid C, Dubourg C, et al. Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans. Hum Genet. 2009;125:393-400 pubmed publisher
    ..We performed an extensive mutational analysis of the entire human DISP1 gene, required for secretion of all hedgehog ligand(s) and which maps to the HPE 10 locus of human chromosome 1q41,..
  8. Vonghachack Y, Odermatt P, Taisayyavong K, Phounsavath S, Akkhavong K, Sayasone S. Transmission of Opisthorchis viverrini, Schistosoma mekongi and soil-transmitted helminthes on the Mekong Islands, Southern Lao PDR. Infect Dis Poverty. 2017;6:131 pubmed publisher
    ..viverrini infection in fresh water fish was 26.9%, with the highest infection rates occurring in Hampala dispa (87.1%), Cyclocheilichthys apogon (85.7%) and Puntius brevis (40.0%)...
  9. Rodriguez Blanco J, Schilling N, Tokhunts R, Giambelli C, Long J, Liang Fei D, et al. The hedgehog processing pathway is required for NSCLC growth and survival. Oncogene. 2013;32:2335-45 pubmed publisher

More Information


  1. Qin H, Samuels J, Wang Y, Zhu Y, Grados M, Riddle M, et al. Whole-genome association analysis of treatment response in obsessive-compulsive disorder. Mol Psychiatry. 2016;21:270-6 pubmed publisher
    ..The top single-nucleotide polymorphism (SNP) was rs17162912 (P=1.76 × 10(-8)), which is near the DISP1 gene on 1q41-q42, a microdeletion region implicated in neurological development...
  2. Basturk O, Berger M, Yamaguchi H, Adsay V, Askan G, Bhanot U, et al. Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma. Mod Pathol. 2017;30:1760-1772 pubmed publisher
    ..In addition, 4/18 (18%) of intraductal tubulopapillary neoplasms had FGFR2 fusions (FGFR2-CEP55, FGFR2-SASS6, DISP1-FGFR2, FGFR2-TXLNA, and FGFR2-VCL) and 1/18 (5.5%) had STRN-ALK fusion...
  3. Kantarci S, Ackerman K, Russell M, Longoni M, Sougnez C, Noonan K, et al. Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH. Am J Med Genet A. 2010;152A:2493-504 pubmed publisher
    ..probe amplification (MLPA) technique, and also sequenced two candidate genes located therein, dispatched 1 (DISP1) and homo sapiens H2.0-like homeobox (HLX)...
  4. Rosenfeld J, Lacassie Y, El Khechen D, Escobar L, Reggin J, Heuer C, et al. New cases and refinement of the critical region in the 1q41q42 microdeletion syndrome. Eur J Med Genet. 2011;54:42-9 pubmed publisher
    ..The gene DISP1, which is involved in sonic hedgehog signaling, has been proposed as a candidate for the midline defects in this ..