DISC1

Summary

Gene Symbol: DISC1
Description: DISC1 scaffold protein
Alias: C1orf136, SCZD9, disrupted in schizophrenia 1 protein
Species: human
Products:     DISC1

Top Publications

  1. Ayhan Y, Abazyan B, Nomura J, Kim R, Ladenheim B, Krasnova I, et al. Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. Mol Psychiatry. 2011;16:293-306 pubmed publisher
    Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 (DISC1) as risk factors for both schizophrenia and mood disorders...
  2. Singh K, De Rienzo G, Drane L, Mao Y, Flood Z, Madison J, et al. Common DISC1 polymorphisms disrupt Wnt/GSK3? signaling and brain development. Neuron. 2011;72:545-58 pubmed publisher
    Disrupted in Schizophrenia-1 (DISC1) is a candidate gene for psychiatric disorders and has many roles during brain development...
  3. Liu Y, Fann C, Liu C, Chen W, Wu J, Hung S, et al. A single nucleotide polymorphism fine mapping study of chromosome 1q42.1 reveals the vulnerability genes for schizophrenia, GNPAT and DISC1: Association with impairment of sustained attention. Biol Psychiatry. 2006;60:554-62 pubmed
    ..046, df = 1). Block 2 (two-SNP), located between intron 4 and intron 5 of the disrupted-in-schizophrenia 1 (DISC1) gene, also showed the most significant results in both the single-locus (z = -3.22, p = ...
  4. Hattori T, Baba K, Matsuzaki S, Honda A, Miyoshi K, Inoue K, et al. A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth. Mol Psychiatry. 2007;12:398-407 pubmed
    Disrupted-in-schizophrenia 1 (DISC1) is a gene disrupted by a (1;11) (q42.1;q14.3) translocation that segregates with major psychiatric disorders in a Scottish family...
  5. Hayesmoore J, Bray N, Owen M, O Donovan M. DISC1 mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1065-9 pubmed publisher
    The hypothesis that genetic variation in Disrupted in Schizophrenia 1 (DISC1) influences risk of schizophrenia and other major psychiatric disorders is supported by a growing body of genetic association data and plausible functional ..
  6. Meyer K, Morris J. Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus. Gene Expr Patterns. 2008;8:494-501 pubmed publisher
    In recent years, Disrupted-In-Schizophrenia 1 (DISC1) has emerged as one of the most promising candidate genes whose disruption confers an increased risk for schizophrenia...
  7. Porteous D, Millar J, Brandon N, Sawa A. DISC1 at 10: connecting psychiatric genetics and neuroscience. Trends Mol Med. 2011;17:699-706 pubmed publisher
    Psychiatric genetics research, as exemplified by the DISC1 gene, aspires to inform on mental health etiology and to suggest improved strategies for intervention...
  8. Green E, Grozeva D, Sims R, Raybould R, Forty L, Gordon Smith K, et al. DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:490-2 pubmed publisher
    ..54) at chromosome 1q42 close to DISC1. An initial sequencing study of DISC1 using 14 unrelated DSM-IV SABP samples from the linkage study identified 2 ..
  9. Zhang X, Tochigi M, Ohashi J, Maeda K, Kato T, Okazaki Y, et al. Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population. Schizophr Res. 2005;79:175-80 pubmed
    Disrupted-in-Schizophrenia-1 (DISC1), identified by cytogenetic approaches in a pedigree with familial psychosis, is considered a candidate susceptibility gene for schizophrenia in some populations...

More Information

Publications102 found, 100 shown here

  1. Malavasi E, Ogawa F, Porteous D, Millar J. DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription. Hum Mol Genet. 2012;21:2779-92 pubmed publisher
    Disrupted-In-Schizophrenia 1 (DISC1), a strong genetic candidate for psychiatric illness, encodes a multicompartmentalized molecular scaffold that regulates interacting proteins with key roles in neurodevelopment and plasticity...
  2. Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, et al. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry. 2009;14:865-73 pubmed publisher
    Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but apart from in the original translocation family, true ..
  3. James R, Adams R, Christie S, Buchanan S, Porteous D, Millar J. Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Mol Cell Neurosci. 2004;26:112-22 pubmed
    b>DISC1 is disrupted by a chromosomal translocation cosegregating with schizophrenia and recurrent major depression in a large Scottish family and has also been reported as a potential susceptibility locus in independent populations...
  4. Johnstone M, Thomson P, Hall J, McIntosh A, Lawrie S, Porteous D. DISC1 in schizophrenia: genetic mouse models and human genomic imaging. Schizophr Bull. 2011;37:14-20 pubmed publisher
    ..One exception is 'Disrupted in schizophrenia 1' (DISC1), a gene locus originally identified in a large Scottish family, showing a heavy burden of major mental illnesses ..
  5. Millar J, Wilson Annan J, Anderson S, Christie S, Taylor M, Semple C, et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet. 2000;9:1415-23 pubmed
    ..These genes have been provisionally named Disrupted-In-Schizophrenia 1 and 2 ( DISC1 and DISC2 ). DISC1 encodes a large protein with no significant sequence homology to other known proteins...
  6. Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, et al. Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A. 2003;100:289-94 pubmed
    ..As schizophrenia is thought to reflect defects in cortical development that are determined by cytoskeletal protein activities, the cellular disturbances we observe with mutant DISC-1 may be relevant to psychopathologic mechanisms. ..
  7. Li Y, Liu B, Hou B, Qin W, Wang D, Yu C, et al. Less efficient information transfer in Cys-allele carriers of DISC1: a brain network study based on diffusion MRI. Cereb Cortex. 2013;23:1715-23 pubmed publisher
    ..with different genotypes in the common missense variant (Ser704Cys) of the Disrupted-in-Schizophrenia-1 (DISC1) gene, which is one of the main susceptibility genes of schizophrenia and other psychiatric disorders...
  8. Mao Y, Ge X, Frank C, Madison J, Koehler A, Doud M, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009;136:1017-31 pubmed publisher
    The Disrupted in Schizophrenia 1 (DISC1) gene is disrupted by a balanced chromosomal translocation (1; 11) (q42; q14.3) in a Scottish family with a high incidence of major depression, schizophrenia, and bipolar disorder...
  9. Narayanan S, Arthanari H, Wolfe M, Wagner G. Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly. J Biol Chem. 2011;286:44266-76 pubmed publisher
    b>DISC1 (Disrupted in schizophrenia-1) plays essential roles in neuronal proliferation, neuronal migration and axon guidance and has been implicated in schizophrenia and related psychiatric disorders...
  10. Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T, et al. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol Psychiatry. 2003;8:685-94 pubmed
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation that segregated with schizophrenia in a Scottish family...
  11. Millar J, Christie S, Porteous D. Yeast two-hybrid screens implicate DISC1 in brain development and function. Biochem Biophys Res Commun. 2003;311:1019-25 pubmed
    b>DISC1 is a candidate gene for involvement in the aetiology of major psychiatric illnesses including schizophrenia. We report here the results of DISC1 yeast two-hybrid screens using human foetal and adult brain libraries...
  12. Millar J, James R, Christie S, Porteous D. Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria. Mol Cell Neurosci. 2005;30:477-84 pubmed
    Several independent studies have identified Disrupted In Schizophrenia 1 (DISC1) as a potential susceptibility factor in the pathogenesis of schizophrenia and severe recurrent major depression...
  13. Song W, Li W, Feng J, Heston L, Scaringe W, Sommer S. Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia. Biochem Biophys Res Commun. 2008;367:700-6 pubmed publisher
    ..In a large Scottish pedigree, a balanced translocation t(1;11) (q42.1;q14.3) disrupting the DISC1 and DISC2 genes segregates with major mental illness, including schizophrenia and unipolar depression...
  14. Tomppo L, Hennah W, Miettunen J, Järvelin M, Veijola J, Ripatti S, et al. Association of variants in DISC1 with psychosis-related traits in a large population cohort. Arch Gen Psychiatry. 2009;66:134-41 pubmed publisher
    ..data from human genetic studies and animal models that implies a role for the disrupted in schizophrenia 1 gene (DISC1) in the etiology of schizophrenia and other major mental illnesses...
  15. Mathieson I, Munafò M, Flint J. Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. Mol Psychiatry. 2012;17:634-41 pubmed publisher
    Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically...
  16. Millar J, Christie S, Semple C, Porteous D. Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. Genomics. 2000;67:69-77 pubmed
    Two candidate genes, DISC1 and DISC2 on chromosome 1, are disrupted by a translocation that segregates with major psychiatric illness. Several DISC1 transcripts contain TRAX (HGMW-approved symbol TSNAX) sequence at the 5' end...
  17. Hayashi M, Portaro F, Bastos M, Guerreiro J, Oliveira V, Gorrão S, et al. Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1. Proc Natl Acad Sci U S A. 2005;102:3828-33 pubmed
    ..and schizophrenia through interactions with the lissencephaly gene 1 (Lis1) and disrupted-in-schizophrenia 1 (DISC1) products, respectively...
  18. Thomson P, Wray N, Millar J, Evans K, Hellard S, Condie A, et al. Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. Mol Psychiatry. 2005;10:657-68, 616 pubmed
    ..disequilibrium in a representative sample of the Scottish population was undertaken across the 510 kb of TRAX and DISC1. SNPs representing each haplotype block were selected for case-control association studies of both schizophrenia ..
  19. Kilpinen H, Ylisaukko Oja T, Hennah W, Palo O, Varilo T, Vanhala R, et al. Association of DISC1 with autism and Asperger syndrome. Mol Psychiatry. 2008;13:187-96 pubmed
    The DISC1 gene at 1q42 has generated considerable interest in various psychiatric diseases, since a balanced translocation interrupting the gene was found to cosegregate with schizophrenia and related mental illnesses in a large Scottish ..
  20. Palo O, Antila M, Silander K, Hennah W, Kilpinen H, Soronen P, et al. Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments. Hum Mol Genet. 2007;16:2517-28 pubmed
    ..Multiple lines of evidence emphasize the role of disrupted-in-schizophrenia-1 (DISC1) gene in psychotic disorders such as SCZ...
  21. Prata D, Mechelli A, Fu C, Picchioni M, Kane F, Kalidindi S, et al. Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function. Mol Psychiatry. 2008;13:915-7, 909 pubmed publisher
  22. Raznahan A, Lee Y, Long R, Greenstein D, Clasen L, Addington A, et al. Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents. Mol Psychiatry. 2011;16:917-26 pubmed publisher
    Disrupted-in-schizophrenia-1 (DISC1), contains two common non-synonymous single-nucleotide polymorphisms (SNPs)--Leu607Phe and Ser704Cys--that modulate (i) facets of DISC1 molecular functioning important for cortical development, (ii) ..
  23. Thomson P, Harris S, Starr J, Whalley L, Porteous D, Deary I. Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neurosci Lett. 2005;389:41-5 pubmed
    b>DISC1 is expressed in the hippocampus and has been identified as a possible genetic risk factor for both schizophrenia and bipolar disorder. These psychiatric illnesses are associated with impaired learning and memory...
  24. Schosser A, Gaysina D, Cohen Woods S, Chow P, Martucci L, Craddock N, et al. Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. Mol Psychiatry. 2010;15:844-9 pubmed publisher
    The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD)...
  25. Sawamura N, Sawamura Yamamoto T, Ozeki Y, Ross C, Sawa A. A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc Natl Acad Sci U S A. 2005;102:1187-92 pubmed
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as the sole gene whose ORF is truncated and cosegregates with major mental illnesses in a Scottish family...
  26. Nakata K, Lipska B, Hyde T, Ye T, Newburn E, Morita Y, et al. DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. Proc Natl Acad Sci U S A. 2009;106:15873-8 pubmed publisher
    Disrupted-In-Schizophrenia-1 (DISC1) is a promising susceptibility gene for major mental illness, but the mechanism of the clinical association is unknown...
  27. Park Y, Jeong J, Lee H, Mun J, Kim J, Lee J, et al. Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A. 2010;107:17785-90 pubmed publisher
    Disrupted-in-schizophrenia 1 (DISC1) has emerged as a schizophrenia-susceptibility gene affecting various neuronal functions...
  28. Carless M, Glahn D, Johnson M, Curran J, Bozaoglu K, Dyer T, et al. Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. Mol Psychiatry. 2011;16:1096-104, 1063 pubmed publisher
    Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major depression, its biological role in these disorders is unclear...
  29. Morris J, Kandpal G, Ma L, Austin C. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet. 2003;12:1591-608 pubmed
    Disrupted-In-Schizophrenia 1 (DISC1) is a novel gene associated with schizophrenia by multiple genetic studies...
  30. Eastwood S, Walker M, Hyde T, Kleinman J, Harrison P. The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain. Hum Mol Genet. 2010;19:2487-96 pubmed publisher
    Disrupted-in-schizophrenia 1 (DISC1) has been genetically associated with schizophrenia, and with brain phenotypes including grey matter volume and working memory performance...
  31. Brandon N, Sawa A. Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci. 2011;12:707-22 pubmed publisher
    ..The disrupted in schizophrenia 1 (DISC1) gene was originally discovered at the breakpoint of an inherited chromosomal translocation, which segregates with ..
  32. Kamiya A, Tan P, Kubo K, Engelhard C, Ishizuka K, Kubo A, et al. Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Arch Gen Psychiatry. 2008;65:996-1006 pubmed publisher
    ..that pericentriolar material 1 protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1 (DISC1) and Bardet-Biedl syndrome 4 protein (BBS4), which provides a crucial pathway for cortical development associated ..
  33. Sachs N, Sawa A, Holmes S, Ross C, DeLisi L, Margolis R. A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder. Mol Psychiatry. 2005;10:758-64 pubmed
    ..predicted to result in the loss of the C-terminal region of the protein product of Disrupted In SChizophrenia 1 (DISC1), a gene located on 1q42.1...
  34. Kim H, Park H, Jung K, Ban J, Ra J, Kim J, et al. Association study of polymorphisms between DISC1 and schizophrenia in a Korean population. Neurosci Lett. 2008;430:60-3 pubmed
    To further clarify schizophrenia (SCZ), disrupted in schizophrenia 1 (DISC1) is a promising candidate gene expressed predominantly within the hippocampus...
  35. Sanders A, Duan J, Levinson D, Shi J, He D, Hou C, et al. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry. 2008;165:497-506 pubmed publisher
    The authors carried out a genetic association study of 14 schizophrenia candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, and ARVCF)...
  36. Leliveld S, Bader V, Hendriks P, Prikulis I, Sajnani G, Requena J, et al. Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease. J Neurosci. 2008;28:3839-45 pubmed publisher
    Disrupted-in-schizophrenia 1 (DISC1) and other genes have been identified recently as potential molecular players in chronic psychiatric diseases such as affective disorders and schizophrenia...
  37. Saetre P, Agartz I, De Franciscis A, Lundmark P, Djurovic S, Kähler A, et al. Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case-control sample. Schizophr Res. 2008;106:237-41 pubmed publisher
    Disrupted-in-schizophrenia-1 (DISC1), located on chromosome 1q42.1, is linked to rare familial schizophrenia in a large Scottish family...
  38. Shimizu S, Matsuzaki S, Hattori T, Kumamoto N, Miyoshi K, Katayama T, et al. DISC1-kendrin interaction is involved in centrosomal microtubule network formation. Biochem Biophys Res Commun. 2008;377:1051-6 pubmed publisher
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation segregating with schizophrenia, bipolar disorder and other major mental illnesses in a Scottish family...
  39. Brauns S, Gollub R, Roffman J, Yendiki A, Ho B, Wassink T, et al. DISC1 is associated with cortical thickness and neural efficiency. Neuroimage. 2011;57:1591-600 pubmed publisher
    Disrupted in schizophrenia 1 (DISC1) is known to play a major role during brain development and is a candidate gene for schizophrenia...
  40. Miyoshi K, Asanuma M, Miyazaki I, Diaz Corrales F, Katayama T, Tohyama M, et al. DISC1 localizes to the centrosome by binding to kendrin. Biochem Biophys Res Commun. 2004;317:1195-9 pubmed
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation that segregated with major mental disorders in a Scottish family...
  41. Millar J, James R, Brandon N, Thomson P. DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. Ann Med. 2004;36:367-78 pubmed
    ..The translocation breakpoint on chromosome 1 is located within the Disrupted in Schizophrenia 1 and 2 genes (DISC1 and DISC2)...
  42. Brandon N, Schurov I, Camargo L, Handford E, Duran Jimeniz B, Hunt P, et al. Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site. Mol Cell Neurosci. 2005;28:613-24 pubmed
    Disrupted in schizophrenia 1 (DISC1) has been identified as a putative risk factor for schizophrenia and affective disorders through study of a Scottish family with a balanced (1;11) (q42.1;q14...
  43. Szeszko P, Hodgkinson C, Robinson D, DeRosse P, Bilder R, Lencz T, et al. DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia. Biol Psychol. 2008;79:103-10 pubmed
    b>DISC1 is considered a susceptibility gene for schizophrenia and schizoaffective disorder, but little is known regarding the potential mechanisms through which it may confer increased risk...
  44. Schumacher J, Laje G, Abou Jamra R, Becker T, Mühleisen T, Vasilescu C, et al. The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations. Hum Mol Genet. 2009;18:2719-27 pubmed publisher
    ..studies, as well as the initial translocation family study, identified the gene Disrupted-In-Schizophrenia-1 (DISC1) as a risk factor for schizophrenia...
  45. Maeda K, Nwulia E, Chang J, Balkissoon R, Ishizuka K, Chen H, et al. Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder. Biol Psychiatry. 2006;60:929-35 pubmed
    The disruption of the disrupted-in-schizophrenia (DISC1) gene segregates with major mental illnesses in a Scottish family...
  46. Nicodemus K, Kolachana B, Vakkalanka R, Straub R, Giegling I, Egan M, et al. Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. Hum Genet. 2007;120:889-906 pubmed
    ..SNPs in RGS4, G72, GRM3, and DISC1 showed evidence for significant statistical epistasis with COMT...
  47. Bradshaw N, Ogawa F, Antolin Fontes B, Chubb J, Carlyle B, Christie S, et al. DISC1, PDE4B, and NDE1 at the centrosome and synapse. Biochem Biophys Res Commun. 2008;377:1091-6 pubmed publisher
    Disrupted-In-Schizophrenia 1 (DISC1) is a risk factor for schizophrenia and other major mental illnesses...
  48. Lim S, Kim H, Nam M, Chung J, Park Y. Association study of DISC1 in Korean population with autism spectrum disorders. Psychiatr Genet. 2009;19:160 pubmed publisher
  49. Hennah W, Tuulio Henriksson A, Paunio T, Ekelund J, Varilo T, Partonen T, et al. A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia. Mol Psychiatry. 2005;10:1097-103 pubmed
    ..that specifically implicate the Translin-Associated Factor X (TRAX) and Disrupted in Schizophrenia 1 and 2 (DISC1 and DISC2) genes in the genetic etiology of schizophrenia...
  50. Camargo L, Collura V, Rain J, Mizuguchi K, Hermjakob H, Kerrien S, et al. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry. 2007;12:74-86 pubmed
    Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with cognitive deficits in both schizophrenics and the normal ageing population...
  51. Qu M, Tang F, Yue W, Ruan Y, Lu T, Liu Z, et al. Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:266-70 pubmed
    Disrupted-in-Schizophrenia-1 (DISC1) is located on 1q42.1, one of the most promising susceptibility loci in schizophrenia linkage studies...
  52. Di Giorgio A, Blasi G, Sambataro F, Rampino A, Papazacharias A, Gambi F, et al. Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding. Eur J Neurosci. 2008;28:2129-36 pubmed publisher
    ..single nucleotide polymorphism leading to a serine-to-cysteine substitution at amino acid 704 (Ser(704)Cys) in the DISC1 protein sequence has been recently associated with schizophrenia and with specific hippocampal abnormalities...
  53. Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio Henriksson A, Suvisaari J, et al. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry. 2009;65:1055-62 pubmed publisher
    Disrupted in Schizophrenia 1 (DISC1) is currently one of the most interesting candidate genes for major mental illness, having been demonstrated to associate with schizophrenia, bipolar disorder, major depression, autism, and Asperger's ..
  54. Blackwood D, Fordyce A, Walker M, St Clair D, Porteous D, Muir W. Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet. 2001;69:428-33 pubmed
    ..results of karyotypic, clinical, and ERP investigations of this family suggest that the recently described genes DISC1 and DISC2, which are directly disrupted by the breakpoint on chromosome 1, may have a role in the development of a ..
  55. Taylor M, Devon R, Millar J, Porteous D. Evolutionary constraints on the Disrupted in Schizophrenia locus. Genomics. 2003;81:67-77 pubmed
    ..The order and orientation of EGLN1, TSNAX, and DISC1 genes are conserved between mammals and F. rubripes...
  56. Hennah W, Varilo T, Kestila M, Paunio T, Arajärvi R, Haukka J, et al. Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Hum Mol Genet. 2003;12:3151-9 pubmed
    ..study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes TRAX, DISC1 and DISC2, using a study sample of 458 Finnish families ascertained for schizophrenia...
  57. Zhang F, Sarginson J, Crombie C, Walker N, St Clair D, Shaw D. Genetic association between schizophrenia and the DISC1 gene in the Scottish population. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:155-9 pubmed
    Several lines of evidence support the involvement of the disrupted in schizophrenia 1 (DISC1) gene in schizophrenia susceptibility, including its original identification in a schizophrenia family with a chromosome translocation, several ..
  58. Song W, Li W, Noltner K, Yan J, Green E, Grozeva D, et al. Identification of high risk DISC1 protein structural variants in patients with bipolar spectrum disorder. Neurosci Lett. 2010;486:136-40 pubmed publisher
    In a large Scottish pedigree, a balanced translocation t (1;11)(q42.1;q14.3) disrupting the DISC1 and DISC2 genes segregates with major mental illness, including schizophrenia and depression...
  59. Moens L, De Rijk P, Reumers J, Van Den Bossche M, Glassee W, De Zutter S, et al. Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population. PLoS ONE. 2011;6:e23450 pubmed publisher
    In recent years, DISC1 has emerged as one of the most credible and best supported candidate genes for schizophrenia and related neuropsychiatric disorders...
  60. Cannon T, Hennah W, van Erp T, Thompson P, Lonnqvist J, Huttunen M, et al. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry. 2005;62:1205-13 pubmed
    ..blocks of single-nucleotide polymorphic markers from a segment of 1q42 spanning the disrupted-in-schizophrenia 1 (DISC1) and translin-associated factor X (TRAX) genes for association with schizophrenia and several endophenotypic ..
  61. Porteous D, Thomson P, Brandon N, Millar J. The genetics and biology of DISC1--an emerging role in psychosis and cognition. Biol Psychiatry. 2006;60:123-31 pubmed
    In the developing field of biological psychiatry, DISC1 stands out by virtue of there being credible evidence, both genetic and biological, for a role in determining susceptibility to schizophrenia and related disorders...
  62. Wood L, Pickering E, Dechairo B. Significant support for DAO as a schizophrenia susceptibility locus: examination of five genes putatively associated with schizophrenia. Biol Psychiatry. 2007;61:1195-9 pubmed
    ..via candidate gene association studies as strong schizophrenia susceptibility loci, including DAO, DAOA, DISC1, DTNBP1, and RGS4...
  63. Hennah W, Tomppo L, Hiekkalinna T, Palo O, Kilpinen H, Ekelund J, et al. Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. Hum Mol Genet. 2007;16:453-62 pubmed
    We have previously reported a robust association between an allelic haplotype of 'Disrupted in Schizophrenia 1' (DISC1) and schizophrenia in a nationwide collection of Finnish schizophrenia families...
  64. Katsel P, Tan W, Abazyan B, Davis K, Ross C, Pletnikov M, et al. Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes. Schizophr Res. 2011;130:238-49 pubmed publisher
    ..Recent studies revealed a critical requirement for Disrupted-in-Schizophrenia 1 (DISC1) in neural development...
  65. Brandon N, Handford E, Schurov I, Rain J, Pelling M, Duran Jimeniz B, et al. Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Mol Cell Neurosci. 2004;25:42-55 pubmed
    Disrupted In Schizophrenia 1 (DISC1) was identified as a potential susceptibility gene for schizophrenia due to its disruption by a balanced t(1;11) (q42;q14) translocation, which has been shown to cosegregate with major psychiatric ..
  66. Hennah W, Porteous D. The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. PLoS ONE. 2009;4:e4906 pubmed publisher
    Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder...
  67. Hodgkinson C, Goldman D, Jaeger J, Persaud S, Kane J, Lipsky R, et al. Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet. 2004;75:862-72 pubmed
    ..The Disrupted in Schizophrenia 1 (DISC1) gene, on chromosome 1q42, was originally discovered and linked to schizophrenia in a Scottish kindred carrying a ..
  68. Callicott J, Straub R, Pezawas L, Egan M, Mattay V, Hariri A, et al. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci U S A. 2005;102:8627-32 pubmed
    Disrupted-in-schizophrenia 1 (DISC1) is a promising schizophrenia candidate gene expressed predominantly within the hippocampus. We typed 12 single-nucleotide polymorphisms (SNPs) that covered the DISC1 gene...
  69. Lipska B, Peters T, Hyde T, Halim N, Horowitz C, Mitkus S, et al. Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Hum Mol Genet. 2006;15:1245-58 pubmed
    b>DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies and clinical data suggesting that risk SNPs impact on hippocampal structure and function...
  70. Takahashi T, Suzuki M, Tsunoda M, Maeno N, Kawasaki Y, Zhou S, et al. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. Psychiatry Res. 2009;172:128-35 pubmed publisher
    The Disrupted-in-Schizophrenia-1 (DISC1) polymorphism is a strong candidate for a schizophrenia-susceptibility gene as it is widely expressed in cortical and limbic regions, but the effect of its genotype variation on brain morphology in ..
  71. Rastogi A, Zai C, Likhodi O, Kennedy J, Wong A. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. Schizophr Res. 2009;114:39-49 pubmed publisher
    ..from genetic linkage, genetic association and biological studies implicates the Disrupted in schizophrenia 1 (DISC1) gene in the etiology and pathophysiology of schizophrenia...
  72. Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, et al. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet. 2006;15:3024-33 pubmed
    Disrupted-in-schizophrenia 1 (DISC1), identified in a pedigree with a familial psychosis with the chromosome translocation (1:11), is a putative susceptibility gene for psychoses such as schizophrenia and bipolar disorder...
  73. Kamiya A, Tomoda T, Chang J, Takaki M, Zhan C, Morita M, et al. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Hum Mol Genet. 2006;15:3313-23 pubmed
    Disrupted-In-Schizophrenia-1 (DISC1) is a unique susceptibility gene for major mental conditions, because of the segregation of its genetic variant with hereditary psychosis in a Scottish pedigree...
  74. Burdick K, Kamiya A, Hodgkinson C, Lencz T, DeRosse P, Ishizuka K, et al. Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet. 2008;17:2462-73 pubmed publisher
    b>DISC1 influences susceptibility to psychiatric disease and related phenotypes. Intact functions of DISC1 and its binding partners, NDEL1 and NDE1, are critical to neurodevelopmental processes aberrant in schizophrenia (SZ)...
  75. Millar J, Pickard B, Mackie S, James R, Christie S, Buchanan S, et al. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science. 2005;310:1187-91 pubmed
    The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown...
  76. Chubb J, Bradshaw N, Soares D, Porteous D, Millar J. The DISC locus in psychiatric illness. Mol Psychiatry. 2008;13:36-64 pubmed
    ..and due to the high prevalence of schizophrenia in this family, they were named Disrupted-in-Schizophrenia-1 (DISC1) and Disrupted-in-Schizophrenia-2 (DISC2)...
  77. Muir W, Pickard B, Blackwood D. Disrupted-in-Schizophrenia-1. Curr Psychiatry Rep. 2008;10:140-7 pubmed
    ..Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders...
  78. Walker R, Hill A, Newman A, Hamilton G, Torrance H, Anderson S, et al. The DISC1 promoter: characterization and regulation by FOXP2. Hum Mol Genet. 2012;21:2862-72 pubmed publisher
    Disrupted in schizophrenia 1 (DISC1) is a leading candidate susceptibility gene for schizophrenia, bipolar disorder and recurrent major depression, which has been implicated in other psychiatric illnesses of neurodevelopmental origin, ..
  79. Eykelenboom J, Briggs G, Bradshaw N, Soares D, Ogawa F, Christie S, et al. A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins. Hum Mol Genet. 2012;21:3374-86 pubmed publisher
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14...
  80. Trost S, Platz B, Usher J, Scherk H, Wobrock T, Ekawardhani S, et al. DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: a voxel-based morphometry (VBM) study. J Psychiatr Res. 2013;47:188-96 pubmed publisher
    b>DISC1 (Disrupted-In-Schizophrenia 1), one of the top candidate genes for schizophrenia, has been associated with a range of major mental illnesses over the last two decades...
  81. Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R, et al. Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet. 2001;10:1611-7 pubmed
    ..for linkage in the combined study sample was obtained for marker D1S2709, which is an intragenic marker of the DISC1 gene, previously suggested as a susceptibility gene for schizophrenia...
  82. Meyer K, Morris J. Disc1 regulates granule cell migration in the developing hippocampus. Hum Mol Genet. 2009;18:3286-97 pubmed publisher
    ..of psychiatric disease, we investigated the function of a highly promising schizophrenia susceptibility gene, DISC1 (Disrupted-In-Schizophrenia 1), in the development of the hippocampus...
  83. Leliveld S, Hendriks P, Michel M, Sajnani G, Bader V, Trossbach S, et al. Oligomer assembly of the C-terminal DISC1 domain (640-854) is controlled by self-association motifs and disease-associated polymorphism S704C. Biochemistry. 2009;48:7746-55 pubmed publisher
    Genetic studies have established a role of disrupted-in-schizophrenia-1 (DISC1) in chronic mental diseases (CMD)...
  84. Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi Takagi A, et al. Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci U S A. 2010;107:5622-7 pubmed publisher
    Neuregulin-1 (NRG1) and Disrupted-in-Schizophrenia-1 (DISC1) are promising susceptibility factors for schizophrenia...
  85. Ishizuka K, Kamiya A, Oh E, Kanki H, Seshadri S, Robinson J, et al. DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature. 2011;473:92-6 pubmed publisher
    ..Here we report that phosphorylation of DISC1, a major susceptibility factor for several mental disorders, acts as a molecular switch from maintaining ..
  86. Osbun N, Li J, O Driscoll M, Strominger Z, Wakahiro M, Rider E, et al. Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene. Am J Med Genet A. 2011;155A:1865-76 pubmed publisher
    ..We fine mapped this deletion and show that it includes Disrupted-in-Schizophrenia 1 (DISC1), a gene implicated in schizophrenia and other psychiatric disorders...
  87. Ogawa F, Kasai M, Akiyama T. A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3. Biochem Biophys Res Commun. 2005;338:771-6 pubmed
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as a candidate gene for schizophrenia. DISC1 is disrupted by a balanced t(1;11)(q42.1;q14...
  88. Perlis R, Purcell S, Fagerness J, Kirby A, Petryshen T, Fan J, et al. Family-based association study of lithium-related and other candidate genes in bipolar disorder. Arch Gen Psychiatry. 2008;65:53-61 pubmed publisher
    ..Recent developments suggest that a broader pool of genes may be associated with this disorder...
  89. Eastwood S, Hodgkinson C, Harrison P. DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release. Mol Psychiatry. 2009;14:556-7 pubmed publisher
  90. Lepagnol Bestel A, Dubertret C, Benmessaoud D, Simonneau M, Ades J, Kacha F, et al. Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations. Psychiatr Genet. 2010;20:298-303 pubmed publisher
    The Disrupted-in-Schizophrenia-1 (DISC1) gene is a promising genetic risk factor for major mental illnesses, especially schizophrenia...
  91. Ratta Apha W, Hishimoto A, Mouri K, Shiroiwa K, Sasada T, Yoshida M, et al. Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain. Neurosci Res. 2013;77:222-7 pubmed publisher
    The Disrupted-in-Schizophrenia 1 (DISC1) gene plays a role in the regulation of neural development...
  92. Burdick K, Hodgkinson C, Szeszko P, Lencz T, Ekholm J, Kane J, et al. DISC1 and neurocognitive function in schizophrenia. Neuroreport. 2005;16:1399-402 pubmed
    We recently reported an association between DISC1 and schizophrenia, schizoaffective disorder, and bipolar disorder. Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning...