DISC1

Summary

Gene Symbol: DISC1
Description: disrupted in schizophrenia 1
Alias: C1orf136, SCZD9, disrupted in schizophrenia 1 protein
Species: human

Top Publications

  1. ncbi Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    Am J Med Genet B Neuropsychiatr Genet 150:155-81. 2009
  2. ncbi Disruption of two novel genes by a translocation co-segregating with schizophrenia
    J K Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Molecular Medicine Centre and MRC Human Genetics Unit, both at Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:1415-23. 2000
  3. ncbi The DISC locus in psychiatric illness
    J E Chubb
    Medical Genetics Section, The Centre for Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 13:36-64. 2008
  4. ncbi DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
    J Kirsty Millar
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK
    Science 310:1187-91. 2005
  5. ncbi Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
    L M Camargo
    Merck Research Labs, Merck and Co, Boston, MA 02115, USA
    Mol Psychiatry 12:74-86. 2007
  6. ncbi Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family
    D H Blackwood
    University Department of Psychiatry, Royal Edinburgh Hospital and University of Edinburgh, Medical Genetics Section, Molecular Medicine Centre, Edinburgh, United Kingdom
    Am J Hum Genet 69:428-33. 2001
  7. ncbi A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia
    W Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Mol Psychiatry 10:1097-103. 2005
  8. ncbi DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
    Jill A Morris
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Hum Mol Genet 12:1591-608. 2003
  9. ncbi The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes
    William Hennah
    Medical Genetics Section, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 4:e4906. 2009
  10. ncbi Association of DISC1 with autism and Asperger syndrome
    H Kilpinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Mol Psychiatry 13:187-96. 2008

Research Grants

  1. Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouse
    Richard E Mains; Fiscal Year: 2010
  2. Chemical Genomic Approaches to Neurobiology of DISC1
    Li Huei Tsai; Fiscal Year: 2010
  3. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2009
  4. Role of cAMP and HCN channels in stress-induced prefrontal dysfunction
    NAO GAMO; Fiscal Year: 2007
  5. Prediction of Psychosis in Alzheimer Disease
    Robert A Sweet; Fiscal Year: 2010
  6. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2007
  7. DISC1 Pathway in Dendritogenesis: Implications for Dopamine Circuit and Cognition
    Atsushi Kamiya; Fiscal Year: 2010
  8. NMDA Reception Function in Lead Neurotoxicity
    Tomas R Guilarte; Fiscal Year: 2010
  9. Nuclear pathway of DISC1 in major mental illnesses: biochemistry and cell biology
    Akira Sawa; Fiscal Year: 2010
  10. Elucidating the effect of Disc1 on neurodevelopment and synaptic transmission
    Joseph Gogos; Fiscal Year: 2007

Detail Information

Publications147 found, 100 shown here

  1. ncbi Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    Am J Med Genet B Neuropsychiatr Genet 150:155-81. 2009
    ..of novel (such as Klf12, Aldh1a1, A2bp1, Ak3l1, Rorb, Rora) and previously known (such as Bdnf, Arntl, Gsk3b, Disc1, Nrg1, Htr2a) candidate genes, blood biomarkers, as well as a comprehensive identification of pathways and ..
  2. ncbi Disruption of two novel genes by a translocation co-segregating with schizophrenia
    J K Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Molecular Medicine Centre and MRC Human Genetics Unit, both at Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:1415-23. 2000
    ..These genes have been provisionally named Disrupted-In-Schizophrenia 1 and 2 ( DISC1 and DISC2 ). DISC1 encodes a large protein with no significant sequence homology to other known proteins...
  3. ncbi The DISC locus in psychiatric illness
    J E Chubb
    Medical Genetics Section, The Centre for Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 13:36-64. 2008
    ..and due to the high prevalence of schizophrenia in this family, they were named Disrupted-in-Schizophrenia-1 (DISC1) and Disrupted-in-Schizophrenia-2 (DISC2)...
  4. ncbi DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
    J Kirsty Millar
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK
    Science 310:1187-91. 2005
    The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown...
  5. ncbi Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
    L M Camargo
    Merck Research Labs, Merck and Co, Boston, MA 02115, USA
    Mol Psychiatry 12:74-86. 2007
    Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with cognitive deficits in both schizophrenics and the normal ageing population...
  6. ncbi Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family
    D H Blackwood
    University Department of Psychiatry, Royal Edinburgh Hospital and University of Edinburgh, Medical Genetics Section, Molecular Medicine Centre, Edinburgh, United Kingdom
    Am J Hum Genet 69:428-33. 2001
    ..results of karyotypic, clinical, and ERP investigations of this family suggest that the recently described genes DISC1 and DISC2, which are directly disrupted by the breakpoint on chromosome 1, may have a role in the development of a ..
  7. ncbi A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia
    W Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Mol Psychiatry 10:1097-103. 2005
    ..that specifically implicate the Translin-Associated Factor X (TRAX) and Disrupted in Schizophrenia 1 and 2 (DISC1 and DISC2) genes in the genetic etiology of schizophrenia...
  8. ncbi DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
    Jill A Morris
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Hum Mol Genet 12:1591-608. 2003
    Disrupted-In-Schizophrenia 1 (DISC1) is a novel gene associated with schizophrenia by multiple genetic studies...
  9. ncbi The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes
    William Hennah
    Medical Genetics Section, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 4:e4906. 2009
    Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder...
  10. ncbi Association of DISC1 with autism and Asperger syndrome
    H Kilpinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Mol Psychiatry 13:187-96. 2008
    The DISC1 gene at 1q42 has generated considerable interest in various psychiatric diseases, since a balanced translocation interrupting the gene was found to cosegregate with schizophrenia and related mental illnesses in a large Scottish ..
  11. ncbi Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling
    Ryota Hashimoto
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, 4 1 1 Suita, Osaka 565 0871, Japan
    Hum Mol Genet 15:3024-33. 2006
    Disrupted-in-schizophrenia 1 (DISC1), identified in a pedigree with a familial psychosis with the chromosome translocation (1:11), is a putative susceptibility gene for psychoses such as schizophrenia and bipolar disorder...
  12. ncbi DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder
    W Hennah
    Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, Scotland
    Mol Psychiatry 14:865-73. 2009
    Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but apart from in the original translocation family, true ..
  13. ncbi Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia
    Joseph H Callicott
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8627-32. 2005
    Disrupted-in-schizophrenia 1 (DISC1) is a promising schizophrenia candidate gene expressed predominantly within the hippocampus. We typed 12 single-nucleotide polymorphisms (SNPs) that covered the DISC1 gene...
  14. ncbi Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
    K Miyoshi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Psychiatry 8:685-94. 2003
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation that segregated with schizophrenia in a Scottish family...
  15. ncbi Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 12:3151-9. 2003
    ..study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes TRAX, DISC1 and DISC2, using a study sample of 458 Finnish families ascertained for schizophrenia...
  16. ncbi Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder
    Kazuhisa Maeda
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 60:929-35. 2006
    The disruption of the disrupted-in-schizophrenia (DISC1) gene segregates with major mental illnesses in a Scottish family...
  17. ncbi Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory
    Tyrone D Cannon
    Department of Psychology, 1285 Franz Hall, University of California Los Angeles, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 62:1205-13. 2005
    ..Chromosome 1q42 is among several genomic regions showing replicated evidence of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this relationship remain to be identified...
  18. ncbi Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments
    Outi M Palo
    Department of Molecular Medicine, National Public Health Insitute, Helsinki, Finland
    Hum Mol Genet 16:2517-28. 2007
    ..Multiple lines of evidence emphasize the role of disrupted-in-schizophrenia-1 (DISC1) gene in psychotic disorders such as SCZ...
  19. ncbi Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders
    N J Brandon
    Merck Sharp and Dohme, The Neuroscience Research Centre, Harlow, Essex, CM20 2QR, UK
    Mol Cell Neurosci 25:42-55. 2004
    Disrupted In Schizophrenia 1 (DISC1) was identified as a potential susceptibility gene for schizophrenia due to its disruption by a balanced t(1;11) (q42;q14) translocation, which has been shown to cosegregate with major psychiatric ..
  20. ncbi Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case-control sample
    Peter Saetre
    Department of Clinical Neuroscience, HUBIN project, Karolinska Institutet and Hospital, R5 00, SE 171 76 Stockholm, Sweden
    Schizophr Res 106:237-41. 2008
    Disrupted-in-schizophrenia-1 (DISC1), located on chromosome 1q42.1, is linked to rare familial schizophrenia in a large Scottish family...
  21. ncbi Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder
    Colin A Hodgkinson
    Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Am J Hum Genet 75:862-72. 2004
    ..The Disrupted in Schizophrenia 1 (DISC1) gene, on chromosome 1q42, was originally discovered and linked to schizophrenia in a Scottish kindred carrying a ..
  22. ncbi Yeast two-hybrid screens implicate DISC1 in brain development and function
    J Kirsty Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, UK
    Biochem Biophys Res Commun 311:1019-25. 2003
    b>DISC1 is a candidate gene for involvement in the aetiology of major psychiatric illnesses including schizophrenia. We report here the results of DISC1 yeast two-hybrid screens using human foetal and adult brain libraries...
  23. ncbi The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Hum Mol Genet 19:2487-96. 2010
    Disrupted-in-schizophrenia 1 (DISC1) has been genetically associated with schizophrenia, and with brain phenotypes including grey matter volume and working memory performance...
  24. ncbi Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria
    R James
    Medical Genetics Section, Department of Medical Sciences, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Mol Cell Neurosci 26:112-22. 2004
    b>DISC1 is disrupted by a chromosomal translocation cosegregating with schizophrenia and recurrent major depression in a large Scottish family and has also been reported as a potential susceptibility locus in independent populations...
  25. ncbi The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations
    Johannes Schumacher
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Hum Mol Genet 18:2719-27. 2009
    ..studies, as well as the initial translocation family study, identified the gene Disrupted-In-Schizophrenia-1 (DISC1) as a risk factor for schizophrenia...
  26. ncbi Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses
    Liisa Tomppo
    Institute for Molecular Medicine Finland FIMM and National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 65:1055-62. 2009
    Disrupted in Schizophrenia 1 (DISC1) is currently one of the most interesting candidate genes for major mental illness, having been demonstrated to associate with schizophrenia, bipolar disorder, major depression, autism, and Asperger's ..
  27. ncbi Chromosome 1 loci in Finnish schizophrenia families
    J Ekelund
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 10:1611-7. 2001
    ..for linkage in the combined study sample was obtained for marker D1S2709, which is an intragenic marker of the DISC1 gene, previously suggested as a susceptibility gene for schizophrenia...
  28. ncbi DISC1, PDE4B, and NDE1 at the centrosome and synapse
    Nicholas J Bradshaw
    Medical Genetics Section, Molecular Medicine Centre, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Biochem Biophys Res Commun 377:1091-6. 2008
    Disrupted-In-Schizophrenia 1 (DISC1) is a risk factor for schizophrenia and other major mental illnesses...
  29. ncbi Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia
    Wenjia Song
    Department of Molecular Genetics, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Biochem Biophys Res Commun 367:700-6. 2008
    ..In a large Scottish pedigree, a balanced translocation t(1;11) (q42.1;q14.3) disrupting the DISC1 and DISC2 genes segregates with major mental illness, including schizophrenia and unipolar depression...
  30. ncbi Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
    b>DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies and clinical data suggesting that risk SNPs impact on hippocampal structure and function...
  31. ncbi Association between genotype at an exonic SNP in DISC1 and normal cognitive aging
    P A Thomson
    Medical Genetics Section, Department of Medical Sciences, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Neurosci Lett 389:41-5. 2005
    b>DISC1 is expressed in the hippocampus and has been identified as a possible genetic risk factor for both schizophrenia and bipolar disorder. These psychiatric illnesses are associated with impaired learning and memory...
  32. ncbi DISC1 and neurocognitive function in schizophrenia
    Katherine E Burdick
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Neuroreport 16:1399-402. 2005
    We recently reported an association between DISC1 and schizophrenia, schizoaffective disorder, and bipolar disorder. Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning...
  33. ncbi No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
    The authors carried out a genetic association study of 14 schizophrenia candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, and ARVCF)...
  34. ncbi Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses
    Atsushi Kamiya
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Gen Psychiatry 65:996-1006. 2008
    ..A role for the centrosome has been suggested in the pathology of major mental illnesses, especially schizophrenia (SZ)...
  35. ncbi Family-based association study of lithium-related and other candidate genes in bipolar disorder
    Roy H Perlis
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Arch Gen Psychiatry 65:53-61. 2008
    ..Recent developments suggest that a broader pool of genes may be associated with this disorder...
  36. ncbi Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population
    Mei Qu
    Institute of Mental Health, Peking University, Beijing, People s Republic of China
    Am J Med Genet B Neuropsychiatr Genet 144:266-70. 2007
    Disrupted-in-Schizophrenia-1 (DISC1) is located on 1q42.1, one of the most promising susceptibility loci in schizophrenia linkage studies...
  37. ncbi A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse
    Naoya Sawamura
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:1187-92. 2005
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as the sole gene whose ORF is truncated and cosegregates with major mental illnesses in a Scottish family...
  38. ncbi Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria
    J Kirsty Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Mol Cell Neurosci 30:477-84. 2005
    Several independent studies have identified Disrupted In Schizophrenia 1 (DISC1) as a potential susceptibility factor in the pathogenesis of schizophrenia and severe recurrent major depression...
  39. ncbi Disc1 regulates granule cell migration in the developing hippocampus
    Kate D Meyer
    Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Hum Mol Genet 18:3286-97. 2009
    ..of psychiatric disease, we investigated the function of a highly promising schizophrenia susceptibility gene, DISC1 (Disrupted-In-Schizophrenia 1), in the development of the hippocampus...
  40. ncbi A single nucleotide polymorphism fine mapping study of chromosome 1q42.1 reveals the vulnerability genes for schizophrenia, GNPAT and DISC1: Association with impairment of sustained attention
    Yu Li Liu
    Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan
    Biol Psychiatry 60:554-62. 2006
    ..The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia...
  41. ncbi Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population
    Qing Ying Chen
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, PR China
    J Psychiatr Res 41:428-34. 2007
    Disrupted-in-Schizophrenia-1 (DISC1) has first been identified as a candidate gene for schizophrenia through study of a Scottish family with a balanced (1; 11) (q42.1; q14.3) translocation...
  42. ncbi Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population
    P A Thomson
    Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, UK
    Mol Psychiatry 10:657-68, 616. 2005
    ..disequilibrium in a representative sample of the Scottish population was undertaken across the 510 kb of TRAX and DISC1. SNPs representing each haplotype block were selected for case-control association studies of both schizophrenia ..
  43. ncbi Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth
    Yuji Ozeki
    Division of Neurobiology and Department of Psychiatry, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:289-94. 2003
    ..As schizophrenia is thought to reflect defects in cortical development that are determined by cytoskeletal protein activities, the cellular disturbances we observe with mutant DISC-1 may be relevant to psychopathologic mechanisms...
  44. ncbi DISC1 mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting
    J B G Hayesmoore
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 147:1065-9. 2008
    The hypothesis that genetic variation in Disrupted in Schizophrenia 1 (DISC1) influences risk of schizophrenia and other major psychiatric disorders is supported by a growing body of genetic association data and plausible functional ..
  45. ncbi A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder
    N A Sachs
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 10:758-64. 2005
    ..predicted to result in the loss of the C-terminal region of the protein product of Disrupted In SChizophrenia 1 (DISC1), a gene located on 1q42.1...
  46. ncbi Evolutionary constraints on the Disrupted in Schizophrenia locus
    Martin S Taylor
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Genomics 81:67-77. 2003
    ..The order and orientation of EGLN1, TSNAX, and DISC1 genes are conserved between mammals and F. rubripes...
  47. ncbi Oligomer assembly of the C-terminal DISC1 domain (640-854) is controlled by self-association motifs and disease-associated polymorphism S704C
    S Rutger Leliveld
    Department of Neuropathology, Heinrich Heine University Dusseldorf, 40225 Dusseldorf, Germany
    Biochemistry 48:7746-55. 2009
    Genetic studies have established a role of disrupted-in-schizophrenia-1 (DISC1) in chronic mental diseases (CMD)...
  48. ncbi Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding
    Annabella Di Giorgio
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Eur J Neurosci 28:2129-36. 2008
    ..single nucleotide polymorphism leading to a serine-to-cysteine substitution at amino acid 704 (Ser(704)Cys) in the DISC1 protein sequence has been recently associated with schizophrenia and with specific hippocampal abnormalities...
  49. ncbi Disrupted-in-Schizophrenia-1
    Walter J Muir
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland EH10 5HF, United Kingdom
    Curr Psychiatry Rep 10:140-7. 2008
    ..Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders...
  50. ncbi A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3
    Fumiaki Ogawa
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 338:771-6. 2005
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as a candidate gene for schizophrenia. DISC1 is disrupted by a balanced t(1;11)(q42.1;q14...
  51. ncbi Association study of polymorphisms between DISC1 and schizophrenia in a Korean population
    Hak Jae Kim
    Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Neurosci Lett 430:60-3. 2008
    To further clarify schizophrenia (SCZ), disrupted in schizophrenia 1 (DISC1) is a promising candidate gene expressed predominantly within the hippocampus...
  52. ncbi Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1
    Mirian A F Hayashi
    Center for Applied Toxinology, Laboratories of Immunogenetics and Immunochemistry, Butantan Institute, and Laboratory of Neurosciences, Universidade Cidade de São Paulo, SP 05503 900, Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 102:3828-33. 2005
    ..and schizophrenia through interactions with the lissencephaly gene 1 (Lis1) and disrupted-in-schizophrenia 1 (DISC1) products, respectively...
  53. ncbi DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1
    Atsushi Kamiya
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Mol Genet 15:3313-23. 2006
    Disrupted-In-Schizophrenia-1 (DISC1) is a unique susceptibility gene for major mental conditions, because of the segregation of its genetic variant with hereditary psychosis in a Scottish pedigree...
  54. ncbi The genetics and biology of DISC1--an emerging role in psychosis and cognition
    David J Porteous
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Crewe Road South, Edinburgh
    Biol Psychiatry 60:123-31. 2006
    In the developing field of biological psychiatry, DISC1 stands out by virtue of there being credible evidence, both genetic and biological, for a role in determining susceptibility to schizophrenia and related disorders...
  55. ncbi Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:967-76. 2009
    Disrupted-in-Schizophrenia 1 (DISC1) and its molecular cascade have been implicated in the pathophysiology of major psychoses...
  56. ncbi Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population
    Xuan Zhang
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, 113 8655 Japan
    Schizophr Res 79:175-80. 2005
    Disrupted-in-Schizophrenia-1 (DISC1), identified by cytogenetic approaches in a pedigree with familial psychosis, is considered a candidate susceptibility gene for schizophrenia in some populations...
  57. ncbi DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
    Kenji Nakata
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 106:15873-8. 2009
    Disrupted-In-Schizophrenia-1 (DISC1) is a promising susceptibility gene for major mental illness, but the mechanism of the clinical association is unknown...
  58. ncbi Genetic association between schizophrenia and the DISC1 gene in the Scottish population
    Feng Zhang
    Department of Mental Health, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK
    Am J Med Genet B Neuropsychiatr Genet 141:155-9. 2006
    Several lines of evidence support the involvement of the disrupted in schizophrenia 1 (DISC1) gene in schizophrenia susceptibility, including its original identification in a schizophrenia family with a chromosome translocation, several ..
  59. ncbi Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus
    Kate D Meyer
    Human Molecular Genetics Program, Department of Pediatrics, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, 2300 Children s Plaza, P O Box 211, Chicago, IL 60614, USA
    Gene Expr Patterns 8:494-501. 2008
    In recent years, Disrupted-In-Schizophrenia 1 (DISC1) has emerged as one of the most promising candidate genes whose disruption confers an increased risk for schizophrenia...
  60. ncbi DISC1 localizes to the centrosome by binding to kendrin
    Ko Miyoshi
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 317:1195-9. 2004
    Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation that segregated with major mental disorders in a Scottish family...
  61. ncbi The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 172:128-35. 2009
    The Disrupted-in-Schizophrenia-1 (DISC1) polymorphism is a strong candidate for a schizophrenia-susceptibility gene as it is widely expressed in cortical and limbic regions, but the effect of its genotype variation on brain morphology in ..
  62. ncbi Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 16:453-62. 2007
    We have previously reported a robust association between an allelic haplotype of 'Disrupted in Schizophrenia 1' (DISC1) and schizophrenia in a nationwide collection of Finnish schizophrenia families...
  63. ncbi DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness
    J Kirsty Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Edinburgh, UK
    Ann Med 36:367-78. 2004
    ..The translocation breakpoint on chromosome 1 is located within the Disrupted in Schizophrenia 1 and 2 genes (DISC1 and DISC2)...
  64. ncbi Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site
    N J Brandon
    Merck Sharp and Dohme Research Labs, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Mol Cell Neurosci 28:613-24. 2005
    Disrupted in schizophrenia 1 (DISC1) has been identified as a putative risk factor for schizophrenia and affective disorders through study of a Scottish family with a balanced (1;11) (q42.1;q14...
  65. ncbi Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia
    J K Millar
    Department of Medical Sciences, The University of Edinburgh, Scotland, United Kingdom
    Genomics 67:69-77. 2000
    Two candidate genes, DISC1 and DISC2 on chromosome 1, are disrupted by a translocation that segregates with major psychiatric illness. Several DISC1 transcripts contain TRAX (HGMW-approved symbol TSNAX) sequence at the 5' end...
  66. ncbi Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii
    C J Carter
    176 Downs Road, Hastings, East Sussex, TN34 2DZ, UK
    Schizophr Bull 35:1163-82. 2009
    ..KPNA3 and RANBP5 control the nuclear import of the influenza virus. Disrupted in schizophrenia 1 (DISC1) controls the microtubule network that is used by viruses as a route to the nucleus, while DTNBP1, MUTED, and ..
  67. ncbi A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia
    S R Datta
    Molecular Psychiatry Laboratory, Research Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, London, UK
    Mol Psychiatry 15:615-28. 2010
    ..PCM1 protein has been shown to interact directly with the disrupted-in-schizophrenia 1 (DISC1) protein, Bardet-Biedl syndrome 4, and Huntingtin-associated protein 1, and is important in neuronal cell growth...
  68. ncbi The genetics of bipolar disorder
    J H Barnett
    Center for Human Genetic Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroscience 164:331-43. 2009
    ..Several of these genes have been associated with the disorder in independent studies (including BDNF, DAOA, DISC1, GRIK4, SLC6A4, and TPH2), but none has been established...
  69. ncbi Molecular genetics of bipolar disorder and depression
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Psychiatry Clin Neurosci 61:3-19. 2007
    ..Several candidate genes for schizophrenia may also be associated with bipolar disorder: G72, DISC1, NRG1, RGS4, NCAM1, DAO, GRM3, GRM4, GRIN2B, MLC1, SYNGR1, and SLC12A6...
  70. ncbi Bioinformatic and experimental survey of 14-3-3-binding sites
    Catherine Johnson
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, U K
    Biochem J 427:69-78. 2010
    ..that 14-3-3 interacts with two residues that are phosphorylated by basophilic kinases and located in the DISC1 (disrupted-in-schizophrenia 1)-interacting region of Ndel1 that is implicated in cognitive disorders...
  71. ncbi Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population
    Akiko Okuda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Neuromolecular Med 12:78-85. 2010
    ..investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major ..
  72. ncbi FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region
    Eliana M Assmann
    Centro de Biologia Molecular Estrutural, Laboratorio Nacional de Luz Sincrotron, Rua Giuseppe Máximo Scolfaro 10 000, CP 6192, 13084 971 Campinas, SP, Brasil
    J Biol Chem 281:9869-81. 2006
    ..In previous studies FEZ1 has been found to interact with protein kinase Czeta, DISC1, the agnoprotein of the human polyomavirus JC virus, and E4B, a U-box-type ubiquitin-protein isopeptide ligase...
  73. ncbi Dual constraints on synapse formation and regression in schizophrenia: neuregulin, neuroligin, dysbindin, DISC1, MuSK and agrin
    Maxwell R Bennett A O
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2006, Australia
    Aust N Z J Psychiatry 42:662-77. 2008
    ....
  74. ncbi Genetic mechanisms of psychosis: in vivo and postmortem genomics
    Daniel R Weinberger
    National Institutes of Health, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Bethesda, Maryland 20892, USA
    Clin Ther 27:S8-15. 2005
    ..Characterizing genes--and translating their effects on brain development and function--has potential implications for improving the prevention and treatment of schizophrenia...
  75. ncbi eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?
    Christopher J Carter
    Schizophr Bull 33:1343-53. 2007
    ..growth factors (BDNF, NRG1), and many of their downstream signaling components or accomplices (AKT1, DAO, DAOA, DISC1, DTNBP1, DPYSL2, IMPA2, NCAM1, NOS1, NOS1AP, PIK3C3, PIP5K2A, PDLIM5, RGS4, YWHAH)...
  76. ncbi HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors
    Kalpana Ghoshal
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e10338. 2010
    ..The purpose of this study was to identify the targets of DNMT3B, an essential DNA methyltransferase in mammals, in colon cancer...
  77. ncbi Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain
    Jonathan D Wood
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2RX, UK
    Hum Mol Genet 18:391-404. 2009
    ..due to alterations in the functions of candidate susceptibility genes such as Disrupted-in-schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1)...
  78. ncbi DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1
    Shinichiro Taya
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    J Neurosci 27:15-26. 2007
    Disrupted-In-Schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. DISC1 is reported to interact with NudE-like (NUDEL), which forms a complex with lissencephaly-1 (LIS1) and 14-3-3epsilon...
  79. ncbi Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3
    Tatiana V Lipina
    Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Synapse 65:234-48. 2011
    Recent studies have identified disrupted-in-schizophrenia-1 (DISC1) as a strong genetic risk factor associated with schizophrenia...
  80. ncbi Molecular mechanism of schizophrenia with reference to disrupted-in-schizophrenia 1 (DISC1)
    Shinsuke Matsuzaki
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurochem Int 51:165-72. 2007
    Disrupted-in-schizophrenia 1 (DISC1) is a gene disrupted by a (1:1) (q42.1;q14.3) translocation that segregates with major psychiatric disorders in a Scottish family...
  81. ncbi A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth
    T Hattori
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Mol Psychiatry 12:398-407. 2007
    Disrupted-in-schizophrenia 1 (DISC1) is a gene disrupted by a (1;11) (q42.1;q14.3) translocation that segregates with major psychiatric disorders in a Scottish family...
  82. ncbi Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neurosci Lett 417:316-21. 2007
    Disrupted in schizophrenia 1 (DISC1) and its molecular cascade are implicated in the pathophysiology of schizophrenia and bipolar disorder...
  83. ncbi Disrupted-in-schizophrenia-1 (DISC1): a key susceptibility factor for major mental illnesses
    Naoya Sawamura
    Consolidated Research Institute for Advanced Science and Medical Care ASMeW, Waseda University, 513 Wasedatsurumaki cho, Shinjuku ku, Tokyo 162 0041, Japan
    Ann N Y Acad Sci 1086:126-33. 2006
    Here we overview Disrupted-in-Schizophrenia-1 (DISC1), a promising lead in studying the pathophysiology of major mental conditions...
  84. ncbi The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans
    John M Allman
    Division of Biology, 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Brain Struct Funct 214:495-517. 2010
    ..We found that the protein encoded by the gene DISC1 (disrupted in schizophrenia) is preferentially expressed by the VENs...
  85. ncbi Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population
    Minori Koga
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neurosci Lett 417:326-9. 2007
    Fasciculation and elongation of protein zeta-1 (FEZ1) is a binding partner of Disrupted-In-Schizophrenia 1 (DISC1)...
  86. ncbi Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Trends Neurosci 32:485-95. 2009
    ..Accumulating evidence suggests that neuregulin-1 (NRG1) and disrupted-in-schizophrenia-1 (DISC1) are probably functionally convergent and play key roles in brain development...
  87. ncbi Altered growth factor signaling pathways as the basis of aberrant stem cell maturation in schizophrenia
    Hans O Kalkman
    Novartis Pharma AG, Novartis Institutes of Biomedical Research Basel, WSJ 386 11 40, Postfach, CH 4002 Basel, Switzerland
    Pharmacol Ther 121:115-22. 2009
    ..evidence has accumulated that the activity of the signaling cascades of Neuregulin-1, Wnt, TGF-beta, BDNF-p75 and DISC1 is different between control subjects and patients with schizophrenia...
  88. ncbi Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain
    Akiko Honda
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700 8558, Japan
    Brain Res Mol Brain Res 122:89-92. 2004
    ..Recently, we reported that FEZ1 interacts with Disrupted-In-Schizophrenia 1 (DISC1), a product of the candidate gene for schizophrenia, and that the interaction between these proteins has a role in ..
  89. ncbi Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1
    Paul J Harrison
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Novartis Found Symp 288:246-55; discussion 255-9, 276-81. 2007
    ..The evidence is strong for neuregulin 1, dysbindin and DISC1, and moderate for several others. However, there are key unanswered questions...
  90. ncbi Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus
    Atsushi Enomoto
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neuron 63:774-87. 2009
    Disrupted-In-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders, regulates neuronal migration and differentiation during mammalian brain development...
  91. ncbi Survey of schizophrenia and bipolar disorder candidate genes using chromatin immunoprecipitation and tiled microarrays (ChIP-chip)
    Erika Pedrosa
    Department of Psychiatry, Division of Basic Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurogenet 23:341-52. 2009
    ..psychiatric genetics, we used ChIP-chip to identify regulatory domains in several candidate genes: NRG1, DTNBP1, DISC1, DAO, DAOA, PDE4B, and COMT...
  92. ncbi Recent advances in postmortem pathology and neurochemistry in schizophrenia
    Brian Dean
    The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Australia
    Curr Opin Psychiatry 22:154-60. 2009
    ..This is a review examining recent data from the study of the postmortem central nervous system (CNS) of patients with schizophrenia...
  93. ncbi Carving chaos: genetics and the classification of mood and psychotic syndromes
    James B Potash
    Mood Disorders Program, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Harv Rev Psychiatry 14:47-63. 2006
    ..DAOA (D-amino acid oxidase activator, also known as G72), has been repeatedly implicated as an overlap gene, while DISC1 and others may constitute additional shared susceptibility genes...
  94. ncbi Molecular mechanisms of stress-induced prefrontal cortical impairment: implications for mental illness
    Avis B Hains
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Learn Mem 15:551-64. 2008
    ..For example, disrupted in schizophrenia 1 (DISC1) normally regulates cAMP levels, while regulator of G protein signaling 4 (RGS4) and diacylglycerol kinase (DGKH)-..
  95. ncbi Schizophrenia: genes at last?
    M J Owen
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Trends Genet 21:518-25. 2005
    ..For other genes, disrupted in schizophrenia 1 (DISC1), D-amino-acid oxidase (DAO), D-amino-acid oxidase activator (DAOA, formerly known as G72) and regulator of G-..
  96. ncbi Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants
    Nobutaka Sakae
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 2 2 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Hum Mol Genet 17:3191-203. 2008
    ..and elongation protein zeta 1), a mammalian ortholog of Caenorhabditis elegans UNC-76, interacts with DISC1 (disrupted in schizophrenia 1), a schizophrenia susceptibility gene product, and polymorphisms of human FEZ1 have ..
  97. ncbi An update on the genetics of schizophrenia
    Nadine Norton
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Curr Opin Psychiatry 19:158-64. 2006
    ..This paper reviews recent molecular genetic studies of schizophrenia and evaluates claims implicating specific genes as susceptibility loci...
  98. ncbi The genetic deconstruction of psychosis
    Michael J Owen
    Department of Psychological Medicine, The School of Medicine, Cardiff University, Cardiff, UK
    Schizophr Bull 33:905-11. 2007
    ..For example, variation in Disrupted in Schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1) may confer susceptibility to a form of illness with mixed features of schizophrenia and ..

Research Grants75

  1. Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouse
    Richard E Mains; Fiscal Year: 2010
    ..In addition, Kalirin interacts with DISC1 (a candidate schizophrenia gene) and HAP1 (a Huntingtin interactor)...
  2. Chemical Genomic Approaches to Neurobiology of DISC1
    Li Huei Tsai; Fiscal Year: 2010
    ..The etiology of these disorders is completely unknown. Disrupted in Schizophrenia-1 (DISC1) was identified as the gene that was disrupted on chromosome 1 in a Scottish family with a high concordance of ..
  3. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2009
    ..Single locus and haplotype associations of NRG1, DTNBP1, DISC1, COMT, DAOA (formerly G72), AKT1, RGS4, APP, PS1, PS2, and MAPI with AD+P will be tested in a large (N=1000) AD+P ..
  4. Role of cAMP and HCN channels in stress-induced prefrontal dysfunction
    NAO GAMO; Fiscal Year: 2007
    ..This mechanism may have particular relevance to schizophrenia, as a loss-of-function mutation in DISC1 (Disrupted In Schizophrenia) likely leads to a disinhibition of cAMP signaling in PFC in many patients with this ..
  5. Prediction of Psychosis in Alzheimer Disease
    Robert A Sweet; Fiscal Year: 2010
    ..Single locus and haplotype associations of NRG1, DTNBP1, DISC1, COMT, DAOA (formerly G72), AKT1, RGS4, APP, PS1, PS2, and MAPI with AD+P will be tested in a large (N=1000) AD+P ..
  6. Prediction of Psychosis in Alzheimer Disease
    Robert Sweet; Fiscal Year: 2007
    ..Single locus and haplotype associations of NRG1, DTNBP1, DISC1, COMT, DAOA (formerly G72), AKT1, RGS4, APP, PS1, PS2, and MAPI with AD+P will be tested in a large (N=1000) AD+P ..
  7. DISC1 Pathway in Dendritogenesis: Implications for Dopamine Circuit and Cognition
    Atsushi Kamiya; Fiscal Year: 2010
    ..One example is the case of Disrupted-in-Schizophrenia-1 (DISC1), which plays a role in various cellular processes in the developing cerebral cortex by mediating interaction with ..
  8. NMDA Reception Function in Lead Neurotoxicity
    Tomas R Guilarte; Fiscal Year: 2010
    ..Disrupted-in-Schizophrenia 1 (DISC1) is a gene that was originally identified at the breakpoint of a balanced (1;11) translocation that co- segregates ..
  9. Nuclear pathway of DISC1 in major mental illnesses: biochemistry and cell biology
    Akira Sawa; Fiscal Year: 2010
    Disrupted-In-Schizophrenia-1 (DISC1) is one of the most promising common susceptibility factors for major mental illnesses, such as schizophrenia and mood disorders...
  10. Elucidating the effect of Disc1 on neurodevelopment and synaptic transmission
    Joseph Gogos; Fiscal Year: 2007
    Recent genetic studies provide strong support for the gene Disrupted-in-Schizophrenia-1 (DISC1) in mental illness...
  11. Elucidating the effect of Disc1 on neurodevelopment and synaptic transmission
    Joseph A Gogos; Fiscal Year: 2010
    Recent genetic studies provide strong support for the gene Disrupted-in-Schizophrenia-1 (DISC1) in mental illness...
  12. Neuroscience Studies on Early Detection of Schizophrenia
    Beng Choon Ho; Fiscal Year: 2007
    ..investigation of two candidate genes (brain-derived neurotrophic factor (BDNF) and Disrupted-in-Schizophrenia 1 (DISC1)) and their relationships with two quantitative phenotypes of schizophrenia (neurocognitive dysfunction and MRI ..
  13. Mutant DISC 1 and Abnormal Neurodevelopment in Mental Illness
    Mikhail V Pletnikov; Fiscal Year: 2010
    ..The Disrupted-ln-Schizophrenia-1 (DISC1) gene is an example of a strong candidate gene for studying the pathogenesis of schizophrenia and associated ..
  14. Viral Pathogenesis of Neural and Behavior Injury
    Mikhail Pletnikov; Fiscal Year: 2007
    ..abstract_text> ..
  15. BORNA VIRUS ALTERS PERINATAL BEHAVIOR DEVELOPMENT
    Mikhail Pletnikov; Fiscal Year: 2003
    ....
  16. Inducible expression of mutant DISC1: transgenic mouse model
    Mikhail Pletnikov; Fiscal Year: 2007
    The Disrupted-In-Schizophrenia-1 (DISC1) gene is an example of a strong candidate gene for studying the pathogenesis of schizophrenia...
  17. Mutant DISC 1 and Abnormal Neurodevelopment in Mental Illness
    Mikhail Pletnikov; Fiscal Year: 2009
    ..The Disrupted-ln-Schizophrenia-1 (DISC1) gene is an example of a strong candidate gene for studying the pathogenesis of schizophrenia and associated ..
  18. Diffusion Tensor Imaging in First-Episode Schizophrenia
    Philip R Szeszko; Fiscal Year: 2010
    ..The identification of these abnormalities at the first episode of illness may be useful for identifying indicators of vulnerability, which may lead to improved early identification of individuals at risk for schizophrenia. ..
  19. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone D Cannon; Fiscal Year: 2010
    ....
  20. Neuroimaging Studies of Frontal Lobe Pathology in OCD
    Philip Szeszko; Fiscal Year: 2005
    ....
  21. Working Memory and Social Functioning in Schizophrenia
    Tyrone Cannon; Fiscal Year: 2007
    ..abstract_text> ..
  22. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone Cannon; Fiscal Year: 2009
    ....
  23. BRAIN FUNCTION AND STRUCTURE IN TWINS WITH SCHIZOPHRENIA
    Tyrone Cannon; Fiscal Year: 2003
    ..abstract_text> ..