Dicer

Summary

Gene Symbol: Dicer
Description: dicer 1, ribonuclease III
Alias: DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2, endoribonuclease Dicer, Dicer1, Dcr-1 homolog, dicer 1, double-stranded RNA-specific endoribonuclease, dicer 1, ribonuclease type III, helicase MOI, helicase with RNAse motif
Species: human
Products:     Dicer

Top Publications

  1. Ma E, Macrae I, Kirsch J, Doudna J. Autoinhibition of human dicer by its internal helicase domain. J Mol Biol. 2008;380:237-43 pubmed publisher
    b>Dicer, a member of the ribonuclease III family of enzymes, processes double-stranded RNA substrates into approximately 21- to 27-nt products that trigger sequence-directed gene silencing by RNA interference...
  2. Bennasser Y, Chable Bessia C, Triboulet R, Gibbings D, Gwizdek C, Dargemont C, et al. Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels. Nat Struct Mol Biol. 2011;18:323-7 pubmed publisher
    ..Inhibition of exportin-5, the karyopherin responsible for pre-miRNA export, downregulated expression of Dicer, the RNase III required for pre-miRNA maturation...
  3. Abe M, Suzuki H, Nishitsuji H, Shida H, Takaku H. Interaction of human T-cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing. FEBS Lett. 2010;584:4313-8 pubmed publisher
    ..A bidentate nuclease called Dicer has been implicated as the protein responsible for the production of short interfering RNAs (siRNAs)...
  4. Kaneko H, Dridi S, Tarallo V, Gelfand B, Fowler B, Cho W, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011;471:325-30 pubmed publisher
    ..These findings reveal a miRNA-independent cell survival function for DICER1 involving retrotransposon transcript degradation, show that Alu RNA can directly cause human pathology, and identify new targets for a major cause of blindness. ..
  5. Potenza N, Papa U, Scaruffi P, Mosca N, Tonini G, Russo A. A novel splice variant of the human dicer gene is expressed in neuroblastoma cells. FEBS Lett. 2010;584:3452-7 pubmed publisher
    b>Dicer is a ribonuclease playing a key role in the biogenesis of microRNAs and small interfering RNAs. Here we report the identification of a novel splice variant of human dicer gene, the first one bearing a modified coding sequence...
  6. Bernstein E, Caudy A, Hammond S, Hannon G. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 2001;409:363-6 pubmed
    ..Here we identify an enzyme, Dicer, which can produce putative guide RNAs...
  7. Coley W, Van Duyne R, Carpio L, Guendel I, Kehn Hall K, Chevalier S, et al. Absence of DICER in monocytes and its regulation by HIV-1. J Biol Chem. 2010;285:31930-43 pubmed publisher
    ..The production of miRNAs is believed to be dependent upon the DICER enzyme...
  8. Choong C, Priest J, Foulkes W. Exploring the endocrine manifestations of DICER1 mutations. Trends Mol Med. 2012;18:503-5 pubmed publisher
    ..In this article, we outline a recent example: a new cancer syndrome caused by germline mutations in DICER1, responsible for microRNA processing. In particular, we discuss the endocrine manifestations of mutations in this crucial gene. ..
  9. Vermeulen A, Behlen L, Reynolds A, Wolfson A, Marshall W, Karpilow J, et al. The contributions of dsRNA structure to Dicer specificity and efficiency. RNA. 2005;11:674-82 pubmed
    b>Dicer processes long double-stranded RNA (dsRNA) and pre-microRNAs to generate the functional intermediates (short interfering RNAs and microRNAs) of the RNA interference pathway...

More Information

Publications120 found, 100 shown here

  1. Gibbings D, Mostowy S, Jay F, Schwab Y, Cossart P, Voinnet O. Selective autophagy degrades DICER and AGO2 and regulates miRNA activity. Nat Cell Biol. 2012;14:1314-21 pubmed
    ..Here, we show that the miRNA-processing enzyme, DICER (also known as DICER1), and the main miRNA effector, AGO2 (also known as eukaryotic translation initiation factor ..
  2. Gross T, Powers L, Boudreau R, Brink B, Reisetter A, Goel K, et al. A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICER. J Biol Chem. 2014;289:12823-34 pubmed publisher
    ..Studies on the miRNA biogenesis machinery led us to focus on the cytosolic RNA endonuclease, DICER. DICER cleaves the stem-loop structure from pre-miRNAs, allowing them to dissociate into their mature 20-22-..
  3. Provost P, Dishart D, Doucet J, Frendewey D, Samuelsson B, Radmark O. Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J. 2002;21:5864-74 pubmed
    ..RNAi) in animals, are mediated by double-stranded RNA (dsRNA) and mechanistically intersect at the ribonuclease Dicer. Here, we report cloning and expression of the 218 kDa human Dicer, and characterization of its ribonuclease ..
  4. Maniataki E, Mourelatos Z. A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev. 2005;19:2979-90 pubmed
    ..The Dicer nuclease produces mature miRNAs and siRNAs from pre-miRNAs and double-stranded RNA (dsRNA), respectively, and ..
  5. Ting A, Suzuki H, Cope L, Schuebel K, Lee B, Toyota M, et al. A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. Cancer Res. 2008;68:2570-5 pubmed publisher
    ..aberrant gene silencing associated with promoter CpG island DNA methylation and the siRNA/miRNA processing enzyme, DICER, in human cancer cells...
  6. Ma Z, Swede H, Cassarino D, Fleming E, Fire A, Dadras S. Up-regulated Dicer expression in patients with cutaneous melanoma. PLoS ONE. 2011;6:e20494 pubmed publisher
    ..b>Dicer, a central enzyme in the multi-component miRNA biogenesis pathway, is involved in cutting precursor miRNAs to ..
  7. Taylor D, Ma E, Shigematsu H, Cianfrocco M, Noland C, Nagayama K, et al. Substrate-specific structural rearrangements of human Dicer. Nat Struct Mol Biol. 2013;20:662-70 pubmed publisher
    b>Dicer has a central role in RNA-interference pathways by cleaving double-stranded RNAs (dsRNAs) to produce small regulatory RNAs...
  8. Chakravarthy S, Sternberg S, Kellenberger C, Doudna J. Substrate-specific kinetics of Dicer-catalyzed RNA processing. J Mol Biol. 2010;404:392-402 pubmed publisher
    The specialized ribonuclease Dicer plays a central role in eukaryotic gene expression by producing small regulatory RNAs-microRNAs (miRNAs) and short interfering RNAs (siRNAs)-from larger double-stranded RNA (dsRNA) substrates...
  9. Heravi Moussavi A, Anglesio M, Cheng S, Senz J, Yang W, Prentice L, et al. Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers. N Engl J Med. 2012;366:234-42 pubmed publisher
    ..These mutations do not obliterate DICER1 function but alter it in specific cell types, a novel mechanism through which perturbation of microRNA processing may be oncogenic. (Funded by the Terry Fox Research Institute and others.). ..
  10. Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol R, et al. Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Cancer Res. 2007;67:2345-50 pubmed
    ..The gene array analysis of BAC and adenocarcinoma showed a transient up-regulation of Dicer (a key effector protein for small interfering RNA and miR function) and PACT along with down-regulation of most ..
  11. Tokumaru S, Suzuki M, Yamada H, Nagino M, Takahashi T. let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis. 2008;29:2073-7 pubmed publisher
    microRNAs (miRNA) are small, endogenously expressed non-coding RNAs that are sequentially processed by Drosha and Dicer from primary transcripts, by negatively regulating the expression of protein-coding genes through either ..
  12. Feng Y, Zhang X, Graves P, Zeng Y. A comprehensive analysis of precursor microRNA cleavage by human Dicer. RNA. 2012;18:2083-92 pubmed publisher
    b>Dicer cleaves double-stranded RNAs (dsRNAs) or precursor microRNAs (pre-miRNAs) to yield ? 22-nt RNA duplexes. The pre-miRNA structure requirement for human Dicer activity is incompletely understood...
  13. Singh S, Bevan S, Patil K, Newton D, Marsden P. Extensive variation in the 5'-UTR of Dicer mRNAs influences translational efficiency. Biochem Biophys Res Commun. 2005;335:643-50 pubmed
    The Dicer enzyme is a key component of the RNA interference pathway and also responsible for the processing of micro RNAs, non-coding RNA molecules which regulate the activity of mRNAs by antisense base pairing...
  14. Wu M, Sabbaghian N, Xu B, Addidou Kalucki S, Bernard C, Zou D, et al. Biallelic DICER1 mutations occur in Wilms tumours. J Pathol. 2013;230:154-64 pubmed publisher
    ..This study has demonstrated that a subset of WTs exhibits two 'hits' in DICER1, suggesting that these mutations could be key events in the pathogenesis of these tumours. ..
  15. Zhang H, Kolb F, Jaskiewicz L, Westhof E, Filipowicz W. Single processing center models for human Dicer and bacterial RNase III. Cell. 2004;118:57-68 pubmed
    b>Dicer is a multidomain ribonuclease that processes double-stranded RNAs (dsRNAs) to 21 nt small interfering RNAs (siRNAs) during RNA interference, and excises microRNAs from precursor hairpins...
  16. Qin Y, Xia Y, Wu W, Han X, Lu C, Ji G, et al. Genetic variants in microRNA biogenesis pathway genes are associated with semen quality in a Han-Chinese population. Reprod Biomed Online. 2012;24:454-61 pubmed publisher
  17. Robb G, Rana T. RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol Cell. 2007;26:523-37 pubmed
    ..We show that RHA interacts in human cells with siRNA, Ago2, TRBP, and Dicer and functions in the RNAi pathway...
  18. Selever J, Gu G, Lewis M, Beyer A, Herynk M, Covington K, et al. Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells. Clin Cancer Res. 2011;17:6510-21 pubmed publisher
    ..Using microarray analysis, we observed that metastatic breast tumors resistant to Tam therapy had elevated levels of Dicer.
  19. Gurtan A, Lu V, Bhutkar A, Sharp P. In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs. RNA. 2012;18:1116-22 pubmed publisher
    b>Dicer is an RNase III family endoribonuclease and haploinsufficient tumor suppressor that processes mature miRNAs from the 5' (5p) or 3' (3p) arm of hairpin precursors...
  20. Tahbaz N, Kolb F, Zhang H, Jaronczyk K, Filipowicz W, Hobman T. Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. EMBO Rep. 2004;5:189-94 pubmed
    PAZ PIWI domain (PPD) proteins, together with the RNA cleavage products of Dicer, form ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs)...
  21. Lau P, Guiley K, De N, Potter C, Carragher B, Macrae I. The molecular architecture of human Dicer. Nat Struct Mol Biol. 2012;19:436-40 pubmed publisher
    b>Dicer is a multidomain enzyme that generates small RNAs for gene silencing in eukaryotes...
  22. Su X, Chakravarti D, Cho M, Liu L, Gi Y, Lin Y, et al. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature. 2010;467:986-90 pubmed publisher
    ..Here we show that TAp63, a p53 family member, suppresses tumorigenesis and metastasis, and coordinately regulates Dicer and miR-130b to suppress metastasis...
  23. Rio Frio T, Bahubeshi A, Kanellopoulou C, Hamel N, Niedziela M, Sabbaghian N, et al. DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. JAMA. 2011;305:68-77 pubmed publisher
    ..DICER1 mutations are associated with both familial MNG and MNG with SLCT, independent of PPB. These germline DICER1 mutations are associated with dysregulation of miRNA expression patterns. ..
  24. Guo X, Liao Q, Chen P, Li X, Xiong W, Ma J, et al. The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma. J Cancer Res Clin Oncol. 2012;138:49-56 pubmed publisher
    ..In this study, we investigated the expression profiles of the two most important enzymes of the miRNA machinery, Drosha and Dicer, which were closely correlated with nasopharyngeal carcinoma (NPC) and patient survival.
  25. Pampalakis G, Diamandis E, Katsaros D, Sotiropoulou G. Down-regulation of dicer expression in ovarian cancer tissues. Clin Biochem. 2010;43:324-7 pubmed publisher
    ..The purpose of this study was to investigate whether Dicer mRNA expression is altered during progression of ovarian cancer...
  26. Papachristou D, Sklirou E, Corradi D, Grassani C, Kontogeorgakos V, Rao U. Immunohistochemical analysis of the endoribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues. Histopathology. 2012;60:E28-36 pubmed publisher
    ..the present study were to determine the protein levels and cellular distribution of the endoribonucleases Drosha, Dicer and Ago2, major components of the microRNA-processing machinery, in benign and malignant soft tissue smooth muscle ..
  27. Doi N, Zenno S, Ueda R, Ohki Hamazaki H, Ui Tei K, Saigo K. Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol. 2003;13:41-6 pubmed
    ..In lower eukaryotes, dsRNA introduced into the cytoplasm is cleaved by the RNaseIII-like enzyme, Dicer, to 21-23 nt RNA (short interfering [si] RNA), which may serve as guide for target mRNA degradation...
  28. Levy C, Khaled M, Robinson K, Veguilla R, Chen P, Yokoyama S, et al. Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell. 2010;141:994-1005 pubmed publisher
    b>DICER is a central regulator of microRNA maturation. However, little is known about mechanisms regulating its expression in development or disease...
  29. Cochrane D, Cittelly D, Howe E, Spoelstra N, McKinsey E, Lapara K, et al. MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer. Horm Cancer. 2010;1:306-19 pubmed publisher
    ..Addition of these miRNAs to ESR1+ cells reduces Dicer protein, whereas antagonizing miR-222 in ESR1- cells increases Dicer protein...
  30. Tarallo V, Hirano Y, Gelfand B, Dridi S, Kerur N, Kim Y, et al. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 2012;149:847-59 pubmed publisher
    ..Our findings also reveal a function of the inflammasome outside the immune system and an immunomodulatory action of mobile elements. ..
  31. Kok K, Ng M, Ching Y, Jin D. Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J Biol Chem. 2007;282:17649-57 pubmed
    Mammalian Dicer interacts with double-stranded RNA-binding protein TRBP or PACT to mediate RNA interference and micro-RNA processing. TRBP and PACT are structurally related but exert opposite regulatory activities on PKR...
  32. Chen W, Zhang Z, Chen J, Zhang J, Zhang J, Wu Y, et al. HCV core protein interacts with Dicer to antagonize RNA silencing. Virus Res. 2008;133:250-8 pubmed publisher
    ..We have further demonstrated that HCV core protein directly interacts with Dicer, an RNase enzyme that generates siRNA in host cells...
  33. Hill D, Ivanovich J, Priest J, Gurnett C, Dehner L, Desruisseau D, et al. DICER1 mutations in familial pleuropulmonary blastoma. Science. 2009;325:965 pubmed publisher
    ..We hypothesize that loss of DICER1 in the epithelium of the developing lung alters the regulation of diffusible factors that promote mesenchymal proliferation. ..
  34. Grelier G, Voirin N, Ay A, Cox D, Chabaud S, Treilleux I, et al. Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Br J Cancer. 2009;101:673-83 pubmed publisher
    b>Dicer, a ribonuclease, is the key enzyme required for the biogenesis of microRNAs and small interfering RNAs and is essential for both mammalian development and cell differentiation...
  35. Tabara H, Yigit E, Siomi H, Mello C. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 2002;109:861-71 pubmed
    ..At an early step in RNAi, an RNaseIII-related enzyme, Dicer (DCR-1), processes long-trigger dsRNA into small interfering RNAs (siRNAs)...
  36. Tang K, Song G, Shi Y, Yuan L, Li Y. Dicer knockdown induces fibronectin-1 expression in HEK293T cells via induction of Egr1. Biochim Biophys Acta. 2010;1800:380-4 pubmed publisher
    b>Dicer is a multidomain ribonuclease III enzyme involved in the biogenesis of microRNAs (miRNAs) and small interfering RNAs (siRNAs); depletion of Dicer was found to impair the migration of endothelial cells...
  37. Jakymiw A, Patel R, Deming N, Bhattacharyya I, Shah P, Lamont R, et al. Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. Genes Chromosomes Cancer. 2010;49:549-59 pubmed publisher
    Recent reports have demonstrated that Dicer, an RNase III endonuclease required for microRNA (miRNA) maturation, is aberrantly expressed in different types of cancer...
  38. Foulkes W, Priest J, Duchaine T. DICER1: mutations, microRNAs and mechanisms. Nat Rev Cancer. 2014;14:662-72 pubmed publisher
    b>Dicer is central to microRNA-mediated silencing and several other RNA interference phenomena that are profoundly embedded in cancer gene networks...
  39. Valencak J, Schmid K, Trautinger F, Wallnöfer W, Muellauer L, Soleiman A, et al. High expression of Dicer reveals a negative prognostic influence in certain subtypes of primary cutaneous T cell lymphomas. J Dermatol Sci. 2011;64:185-90 pubmed publisher
    ..b>Dicer, a ribonuclease III-like enzyme is essential for miRNA processing...
  40. Lin R, Lin Y, Chen J, Kuo H, Chen Y, Diccianni M, et al. microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res. 2010;70:7841-50 pubmed publisher
    ..To investigate the microRNA (miRNA) profile and role of Dicer and Drosha in neuroblastoma, we assessed the expression of 162 human miRNAs, Dicer and Drosha in 66 neuroblastoma ..
  41. Ma H, Yuan H, Yuan Z, Yu C, Wang R, Jiang Y, et al. Genetic variations in key microRNA processing genes and risk of head and neck cancer: a case-control study in Chinese population. PLoS ONE. 2012;7:e47544 pubmed publisher
    ..this hypothesis, we genotyped three SNPs at miRNA binding sites of miRNA processing genes (rs1057035 in 3'UTR of DICER, rs3803012 in 3'UTR of RAN and rs10773771 in 3'UTR of HIWI) with a case-control study including 397 HNC cases and ..
  42. Chiosea S, Barnes E, Lai S, Egloff A, Sargent R, Hunt J, et al. Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression. Virchows Arch. 2008;452:629-35 pubmed publisher
    ..miR maturation requires functional microRNA machinery, including the Dicer protein...
  43. Zighelboim I, Reinhart A, Gao F, Schmidt A, Mutch D, Thaker P, et al. DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma. Cancer. 2011;117:1446-53 pubmed publisher
    ..The factors that influence DICER1 transcript levels in primary endometrial cancers remain unknown. ..
  44. Daniels S, Melendez Peña C, Scarborough R, Daher A, Christensen H, El Far M, et al. Characterization of the TRBP domain required for dicer interaction and function in RNA interference. BMC Mol Biol. 2009;10:38 pubmed publisher
    b>Dicer, Ago2 and TRBP are the minimum components of the human RNA-induced silencing complex (RISC). While Dicer and Ago2 are RNases, TRBP is the double-stranded RNA binding protein (dsRBP) that loads small interfering RNA into the RISC...
  45. Ando Y, Maida Y, Morinaga A, Burroughs A, Kimura R, Chiba J, et al. Two-step cleavage of hairpin RNA with 5' overhangs by human DICER. BMC Mol Biol. 2011;12:6 pubmed publisher
    b>DICER is an RNase III family endoribonuclease that processes precursor microRNAs (pre-miRNAs) and long double-stranded RNAs, generating microRNA (miRNA) duplexes and short interfering RNA duplexes with 20~23 nucleotides (nts) in length...
  46. Matsuda S, Ichigotani Y, Okuda T, Irimura T, Nakatsugawa S, Hamaguchi M. Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase. Biochim Biophys Acta. 2000;1490:163-9 pubmed
    ..8, it might be a human homolog of the K12H4.8. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 14q31 near the marker D14S605. ..
  47. Bennasser Y, Jeang K. HIV-1 Tat interaction with Dicer: requirement for RNA. Retrovirology. 2006;3:95 pubmed
    b>Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA)...
  48. Park J, Heo I, Tian Y, Simanshu D, Chang H, Jee D, et al. Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature. 2011;475:201-5 pubmed publisher
    ..silencing is a class of approximately 22-nucleotide RNAs that are processed from double-stranded RNA precursors by Dicer. Accurate processing by Dicer is crucial for the functionality of microRNAs (miRNAs)...
  49. Inoue T, Iinuma H, Ogawa E, Inaba T, Fukushima R. Clinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer. Oncol Rep. 2012;27:1759-64 pubmed publisher
    ..Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients. ..
  50. Ren Y, Li G, Wu J, Xue Y, Song Y, Lv L, et al. Dicer-dependent biogenesis of small RNAs derived from 7SL RNA. PLoS ONE. 2012;7:e40705 pubmed publisher
    It has been reported that decreased Dicer expression leads to Alu RNAs accumulation in human retinal pigmented epithelium cells, and Dicer may process the endogenous SINE/B1 RNAs (the rodent equivalent of the primate Alu RNAs) into small ..
  51. Koscianska E, Starega Roslan J, Krzyzosiak W. The role of Dicer protein partners in the processing of microRNA precursors. PLoS ONE. 2011;6:e28548 pubmed publisher
    One of the cellular functions of the ribonuclease Dicer is to process microRNA precursors (pre-miRNAs) into mature microRNAs (miRNAs). Human Dicer performs this function in cooperation with its protein partners, AGO2, PACT and TRBP...
  52. Irvin Wilson C, Chaudhuri G. Alternative initiation and splicing in dicer gene expression in human breast cells. Breast Cancer Res. 2005;7:R563-9 pubmed
    b>Dicer is a ribonuclease that mediates RNA interference both at the transcriptional and the post-transcriptional levels. Human dicer gene expression is regulated in different tissues...
  53. Christensen H, Daher A, Soye K, Frankel L, Alexander M, Lainé S, et al. Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. J Virol. 2007;81:5121-31 pubmed
    ..The mechanism uses the RNA-induced silencing complex, in which Dicer, Ago2, and the human immunodeficiency virus type 1 (HIV-1) TAR RNA binding protein (TRBP) are the main components...
  54. Zheng Z, Sun X, Fu W, Guan Y, Gao F, Wang Y, et al. Decreased expression of DICER1 in gastric cancer. Chin Med J (Engl). 2007;120:2099-104 pubmed
  55. Lau P, Potter C, Carragher B, Macrae I. Structure of the human Dicer-TRBP complex by electron microscopy. Structure. 2009;17:1326-32 pubmed publisher
    b>Dicer is a specialized ribonuclease that initiates RNA interference (RNAi) by cleaving double-stranded RNA (dsRNA) into small RNA fragments about 22 nucleotides long...
  56. Suarez Y, Fernandez Hernando C, Pober J, Sessa W. Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res. 2007;100:1164-73 pubmed
    b>Dicer is a key enzyme involved in the maturation of microRNAS (miRNAs). miRNAs have been shown to be regulators of gene expression participating in the control of a wide range of physiological pathways...
  57. Asada S, Takahashi T, Isodono K, Adachi A, Imoto H, Ogata T, et al. Downregulation of Dicer expression by serum withdrawal sensitizes human endothelial cells to apoptosis. Am J Physiol Heart Circ Physiol. 2008;295:H2512-21 pubmed publisher
    Although the modulated expression of Dicer is documented upon neoplastic transformation, little is known of the regulation of Dicer expression by environmental stimuli and its roles in the regulation of cellular functions in primary ..
  58. Wiesen J, Tomasi T. Dicer is regulated by cellular stresses and interferons. Mol Immunol. 2009;46:1222-8 pubmed publisher
    The generation of microRNAs is dependent on the RNase III enzyme Dicer, the levels of which vary in different normal cells and in disease states...
  59. Hu Q, Tanasa B, Trabucchi M, Li W, Zhang J, Ohgi K, et al. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. Nat Struct Mol Biol. 2012;19:1168-75 pubmed publisher
    ..These transcripts are processed, initially in a DICER-dependent fashion, into small RNAs (~28-65 nt) referred to as repeat-induced RNAs that cause the degradation of a ..
  60. Haase A, Jaskiewicz L, Zhang H, Lainé S, Sack R, Gatignol A, et al. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep. 2005;6:961-7 pubmed
    b>Dicer is a key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also has a role in the effector steps of RNA silencing...
  61. Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, et al. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature. 2009;461:230-5 pubmed publisher
    ..polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner...
  62. Gu S, Jin L, Zhang Y, Huang Y, Zhang F, Valdmanis P, et al. The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell. 2012;151:900-11 pubmed publisher
    Short hairpin RNA (shRNA)-induced RNAi is used for biological discovery and therapeutics. Dicer, whose normal role is to liberate endogenous miRNAs from their precursors, processes shRNAs into different biologically active siRNAs, ..
  63. Merritt W, Lin Y, Han L, Kamat A, Spannuth W, Schmandt R, et al. Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med. 2008;359:2641-50 pubmed publisher
    We studied Dicer and Drosha, components of the RNA-interference machinery, in ovarian cancer...
  64. Schultz K, Pacheco M, Yang J, Williams G, Messinger Y, Hill D, et al. Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: a report from the International Pleuropulmonary Blastoma Registry. Gynecol Oncol. 2011;122:246-50 pubmed publisher
    ..Primary ovarian neoplasms, particularly OSCST, are a manifestation of the familial PPB syndrome and may be the initial clinical presentation of DICER1 mutations within a family. ..
  65. Ando Y, Tomaru Y, Morinaga A, Burroughs A, Kawaji H, Kubosaki A, et al. Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. PLoS ONE. 2011;6:e23385 pubmed publisher
    ..Additional characterization of the NUP153-DICER1 association suggests NUP153 plays a crucial role in the nuclear localization of the DICER1 protein. ..
  66. Yan M, Huang H, Wang T, Wan Y, Cui S, Liu Z, et al. Dysregulated expression of dicer and drosha in breast cancer. Pathol Oncol Res. 2012;18:343-8 pubmed publisher
    ..Altered expression of Dicer and Drosha, two key enzymes in the miRNA maturation, is believed to be one of the most important mechanisms...
  67. Li X, Tian X, Zhang B, Zhang Y, Chen J. Variation in dicer gene is associated with increased survival in T-cell lymphoma. PLoS ONE. 2012;7:e51640 pubmed publisher
    b>Dicer, an endonuclease in RNase III family, is essential for the RNA interference (RNAi) pathway...
  68. Klein S, Lee H, Ghahremani S, Kempert P, Ischander M, Teitell M, et al. Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome. J Med Genet. 2014;51:294-302 pubmed publisher
    ..We propose that mutations affecting the metal binding sites of the DICER1 RNase IIIb domain alter the balance of 3p and 5p microRNAs leading to deregulation of these growth signalling pathways, causing a novel human overgrowth syndrome. ..
  69. Lima W, Murray H, Nichols J, Wu H, Sun H, Prakash T, et al. Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids. J Biol Chem. 2009;284:2535-48 pubmed publisher
    Human Dicer is an integral component of the RNA interference pathway...
  70. Paroo Z, Ye X, Chen S, Liu Q. Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell. 2009;139:112-22 pubmed publisher
    ..We determined that the human miRNA-generating complex is comprised of Dicer and phospho-TRBP isoforms. Phosphorylation of TRBP is mediated by the mitogen-activated protein kinase (MAPK) Erk...
  71. Sand M, Gambichler T, Skrygan M, Sand D, Scola N, Altmeyer P, et al. Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer. Cancer Invest. 2010;28:649-53 pubmed publisher
    ..study, we investigated expression profiles of the two most important enzymes of the miRNA machinery, Drosha and Dicer, in relation to epithelial skin cancer and its premalignant stage...
  72. Kim J, Choi Y, Jin G, Kang H, Choi J, Jeon H, et al. Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study. Mol Carcinog. 2010;49:913-21 pubmed publisher
    ..In stage 1 of the study, 24 SNPs in the 11 miRNA biosynthesis genes (DROSHA, DGCR8, RAN, XPO5, DICER, AGO1, AGO2, HIWI, GEMIN3, GEMIN4, and TRBP) were genotyped in 100 lung cancer patients and 100 healthy controls ..
  73. Stratmann J, Wang C, Gnosa S, Wallin A, Hinselwood D, Sun X, et al. Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients. BMC Cancer. 2011;11:345 pubmed publisher
    b>Dicer is aberrantly expressed in several types of cancers...
  74. Hutvagner G, McLachlan J, Pasquinelli A, Balint E, Tuschl T, Zamore P. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 2001;293:834-8 pubmed
    ..Targeted destruction in cultured human cells of the messenger RNA encoding the enzyme Dicer, which acts in the RNA interference pathway, leads to accumulation of the let-7 precursor...
  75. Soifer H, Sano M, Sakurai K, Chomchan P, Saetrom P, Sherman M, et al. A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs. Nucleic Acids Res. 2008;36:6511-22 pubmed publisher
    In humans a single species of the RNAseIII enzyme Dicer processes both microRNA precursors into miRNAs and long double-stranded RNAs into small interfering RNAs (siRNAs)...
  76. Chendrimada T, Gregory R, Kumaraswamy E, Norman J, Cooch N, Nishikura K, et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005;436:740-4 pubmed
    ..These pre-miRNAs are cleaved by the RNase III Dicer to generate mature miRNAs that direct the RNA-induced silencing complex (RISC) to messenger RNAs with ..
  77. Tang K, Wang Y, Wang P, Chen M, Chen Y, Hu H, et al. Upregulation of PHLDA2 in Dicer knockdown HEK293 cells. Biochim Biophys Acta. 2007;1770:820-5 pubmed
    ..To address whether RNAi machinery could regulate the chromatin structure of imprinted genes, we knocked down Dicer in HEK293 cells and found that the expression of PHLDA2, one of the several genes in the imprinted gene domain of ..
  78. Clague J, Lippman S, Yang H, Hildebrandt M, Ye Y, Lee J, et al. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. Mol Carcinog. 2010;49:183-9 pubmed publisher
    ..09; 95% CI, 1.23-3.56). Likewise, patients with at least one variant allele of DICER:rs3742330 had a significantly increased risk of OPL (OR, 2.09; 95% CI, 1.03-4.24)...
  79. Sinkkonen L, Hugenschmidt T, Filipowicz W, Svoboda P. Dicer is associated with ribosomal DNA chromatin in mammalian cells. PLoS ONE. 2010;5:e12175 pubmed publisher
    ..Immunostaining of mitotic chromosomes with antibodies visualizing either endogenous or ectopically expressed Dicer in mammalian cells revealed association of the protein with ribosomal DNA (rDNA) repeats...
  80. Zhu D, Fan L, Lu R, Fang C, Shen W, Zou Z, et al. Downregulated Dicer expression predicts poor prognosis in chronic lymphocytic leukemia. Cancer Sci. 2012;103:875-81 pubmed publisher
    ..Alterations in microRNAs (miRNAs) expression have been proposed to play a role in CLL pathogenesis. Dicer and Drosha are the main regulators of miRNA biogenesis, and deregulation of their expression has been indicated as ..
  81. Chang L, Hu W, Ye C, Yao B, Song L, Wu X, et al. miR-3928 activates ATR pathway by targeting Dicer. RNA Biol. 2012;9:1247-54 pubmed publisher
    ..After exposed to X-rays, miR-3928 expression increased in 1.5 h and then decreased, meanwhile Dicer, a key component in the miRNA processing machinery, increased gradually...
  82. Fukagawa T, Nogami M, Yoshikawa M, Ikeno M, Okazaki T, Takami Y, et al. Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat Cell Biol. 2004;6:784-91 pubmed
    RNA interference is an evolutionarily conserved gene-silencing pathway in which the nuclease Dicer cleaves double-stranded RNA into small interfering RNAs...
  83. Bahubeshi A, Bal N, Rio Frio T, Hamel N, Pouchet C, Yilmaz A, et al. Germline DICER1 mutations and familial cystic nephroma. J Med Genet. 2010;47:863-6 pubmed publisher
    ..These results provide further evidence implicating miRNA dysregulation in tumourigenesis. ..
  84. Slade I, Bacchelli C, Davies H, Murray A, Abbaszadeh F, Hanks S, et al. DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome. J Med Genet. 2011;48:273-8 pubmed publisher
    ..They have termed this condition 'DICER1 syndrome'. ACCESSION NUMBERS: The cDNA Genbank accession number for the DICER1 sequence reported in this paper is NM_030621.2. ..
  85. Doyle M, Badertscher L, Jaskiewicz L, Güttinger S, Jurado S, Hugenschmidt T, et al. The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal. RNA. 2013;19:1238-52 pubmed publisher
    b>Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and double-stranded RNA into ?21-nt-long products ultimately triggering sequence-dependent gene silencing...
  86. Chiosea S, Jelezcova E, Chandran U, Acquafondata M, McHale T, Sobol R, et al. Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Am J Pathol. 2006;169:1812-20 pubmed
    ..Production and function of microRNA requires coordinated processing by proteins of the microRNA machinery. Dicer, an RNase III endonuclease, is an essential component of the microRNA machinery...
  87. Sasaki T, Shimizu N. Evolutionary conservation of a unique amino acid sequence in human DICER protein essential for binding to Argonaute family proteins. Gene. 2007;396:312-20 pubmed
    The Argonaute family and DICER proteins are major key proteins involved in the RNA-mediated gene silencing mechanism of various species...
  88. Macrae I, Ma E, Zhou M, Robinson C, Doudna J. In vitro reconstitution of the human RISC-loading complex. Proc Natl Acad Sci U S A. 2008;105:512-7 pubmed publisher
    ..by the action of a specialized assembly called the RISC-loading complex (RLC), comprising the proteins Ago2, Dicer, and TRBP. Here we show that the human RLC assembles spontaneously in vitro from purified components...
  89. de Boer C, Eini R, Gillis A, Stoop H, Looijenga L, White S. DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours. BMC Res Notes. 2012;5:569 pubmed publisher
    ..Overall our findings suggest a mutation frequency in TGCTs of ~1%. We conclude therefore that hot-spot mutations, frequently seen in Sertoli-Leydig cell tumours, are not common in TGCTs. ..
  90. Sabbaghian N, Bahubeshi A, Shuen A, Kanetsky P, Tischkowitz M, Nathanson K, et al. Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours. BMC Res Notes. 2013;6:127 pubmed publisher
    ..To further explore the importance of DICER1 mutations in the etiology of testicular germ cell tumors (TGCT), we studied germ-line DNA samples from 43 probands diagnosed with familial TGCT...
  91. White E, Schlackow M, Kamieniarz Gdula K, Proudfoot N, Gullerova M. Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA. Nat Struct Mol Biol. 2014;21:552-9 pubmed publisher
    b>Dicer is a central enzymatic player in RNA-interference pathways that acts to regulate gene expression in nearly all eukaryotes...
  92. Höck J, Weinmann L, Ender C, Rüdel S, Kremmer E, Raabe M, et al. Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep. 2007;8:1052-60 pubmed
    ..messenger ribonucleoproteins (mRNPs) showed that Ago1 and Ago2 reside in three complexes with distinct Dicer and RNA-induced silencing complex activities...