DHX9

Summary

Gene Symbol: DHX9
Description: DExH-box helicase 9
Alias: DDX9, LKP, NDH2, NDHII, RHA, ATP-dependent RNA helicase A, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9, DEAH (Asp-Glu-Ala-His) box helicase 9, DEAH (Asp-Glu-Ala-His) box polypeptide 9, DEAH box protein 9, DEAH-box helicase 9, RNA helicase A, leukophysin, nuclear DNA helicase II
Species: human
Products:     DHX9

Top Publications

  1. Loor G, Zhang S, Zhang P, Toomey N, Lee M. Identification of DNA replication and cell cycle proteins that interact with PCNA. Nucleic Acids Res. 1997;25:5041-6 pubmed
    ..Of the cell cycle proteins investigated, CDK2, CDK4 and CDK5 were bound. This study presents strong evidence that PCNA is a component of protein complexes containing DNA replication, repair and cell cycle regulatory proteins. ..
  2. Tetsuka T, Uranishi H, Sanda T, Asamitsu K, Yang J, Wong Staal F, et al. RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator. Eur J Biochem. 2004;271:3741-51 pubmed
    b>RNA helicase A (RHA), a member of DNA and RNA helicase family containing ATPase activity, is involved in many steps of gene expression such as transcription and mRNA export...
  3. Lee C, Hurwitz J. A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3' to 5' direction. J Biol Chem. 1992;267:4398-407 pubmed
    ..We propose that the enzyme can bind to both single-stranded RNA and DNA and hydrolyze ATP, but by virtue of its greater stability on RNA, the enzyme can only translocate on RNA possessing 3' single-stranded regions. ..
  4. Aratani S, Fujii R, Oishi T, Fujita H, Amano T, Ohshima T, et al. Dual roles of RNA helicase A in CREB-dependent transcription. Mol Cell Biol. 2001;21:4460-9 pubmed
    b>RNA helicase A (RHA) is a member of an ATPase/DNA and RNA helicase family and is a homologue of Drosophila maleless protein (MLE), which regulates X-linked gene expression...
  5. Fujii R, Okamoto M, Aratani S, Oishi T, Ohshima T, Taira K, et al. A Role of RNA Helicase A in cis-Acting Transactivation Response Element-mediated Transcriptional Regulation of Human Immunodeficiency Virus Type 1. J Biol Chem. 2001;276:5445-51 pubmed
    b>RNA helicase A (RHA) has two double-stranded (ds) RNA-binding domains (dsRBD1 and dsRBD2)...
  6. Bolinger C, Sharma A, Singh D, Yu L, Boris Lawrie K. RNA helicase A modulates translation of HIV-1 and infectivity of progeny virions. Nucleic Acids Res. 2010;38:1686-96 pubmed publisher
    ..Previously several animal retroviruses were determined to mediate Dhx9/RNA helicase A (RHA) interaction with a 5' terminal post-transcriptional control element (PCE) for efficient translation...
  7. Tang H, Wong Staal F. Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirus. J Biol Chem. 2000;275:32694-700 pubmed
    ..Two cellular proteins, RNA helicase A (RHA) and Tip-associated protein (Tap) were identified as binding to CTE and were proposed to function as CTE ..
  8. Tang H, McDonald D, Middlesworth T, Hope T, Wong Staal F. The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domain. Mol Cell Biol. 1999;19:3540-50 pubmed
    Human RNA helicase A was recently identified to be a shuttle protein which interacts with the constitutive transport element (CTE) of type D retroviruses...
  9. Li J, Tang H, Mullen T, Westberg C, Reddy T, Rose D, et al. A role for RNA helicase A in post-transcriptional regulation of HIV type 1. Proc Natl Acad Sci U S A. 1999;96:709-14 pubmed
    ..g., HIV). Recently, we identified RNA helicase A (RHA) as a potential cellular cofactor for CTE...

More Information

Publications86

  1. Jain A, Bacolla A, Chakraborty P, Grosse F, Vasquez K. Human DHX9 helicase unwinds triple-helical DNA structures. Biochemistry. 2010;49:6992-9 pubmed publisher
    ..Herein, we find that the DHX9 helicase co-immunoprecipitates with triplex DNA structures in mammalian cells, suggesting a role in the maintenance ..
  2. Anderson S, Schlegel B, Nakajima T, Wolpin E, Parvin J. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet. 1998;19:254-6 pubmed
    ..We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex...
  3. Nakajima T, Uchida C, Anderson S, Lee C, Hurwitz J, Parvin J, et al. RNA helicase A mediates association of CBP with RNA polymerase II. Cell. 1997;90:1107-12 pubmed
    ..Here we show that complex formation between CBP and RNA polymerase II requires RNA helicase A (RHA), a nuclear DNA/RNA helicase that is related to the Drosophila male dosage compensation factor mle...
  4. Chakraborty P, Grosse F. Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes. DNA Repair (Amst). 2011;10:654-65 pubmed publisher
    Human DHX9 helicase, also known as nuclear DNA helicase II (NDH II) and RNA helicase A (RHA), belongs to the SF2 superfamily of nucleic acid unwinding enzymes...
  5. Sch tz P, Wahlberg E, Karlberg T, Hammarstr m M, Collins R, Flores A, et al. Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein. J Mol Biol. 2010;400:768-82 pubmed publisher
    ..Here we present the crystal structures of the conserved domain 1 of the DEIH-motif-containing helicase DHX9 and of the DEAD-box helicase DDX20...
  6. Ranji A, Shkriabai N, Kvaratskhelia M, Musier Forsyth K, Boris Lawrie K. Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs. J Biol Chem. 2011;286:5328-37 pubmed publisher
    The DExH protein RNA helicase A (RHA) plays numerous roles in cell physiology, and post-transcriptional activation of gene expression is a major role among them...
  7. Sadler A, Latchoumanin O, Hawkes D, Mak J, Williams B. An antiviral response directed by PKR phosphorylation of the RNA helicase A. PLoS Pathog. 2009;5:e1000311 pubmed publisher
    ..Here, PKR is shown to interact with an essential RNA helicase, RHA. Moreover, RHA is identified as a substrate for PKR, with phosphorylation perturbing the association of the ..
  8. Robb G, Rana T. RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol Cell. 2007;26:523-37 pubmed
    ..Here we report the identification of RNA helicase A (RHA) as a human RISC-associated factor...
  9. Lee C, Hurwitz J. Human RNA helicase A is homologous to the maleless protein of Drosophila. J Biol Chem. 1993;268:16822-30 pubmed
    b>RNA helicase A is an abundant nuclear enzyme of HeLa cells that unwinds double-stranded RNA in a 3' to 5'direction (Lee, C. G., and Hurwitz, J. (1992) J. Biol. Chem. 267, 4398-4407)...
  10. Zhang S, Hemmerich P, Grosse F. Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome. Cell Biol Int. 2007;31:1109-21 pubmed
    ..b>Nuclear DNA helicase II (NDH II), also called RNA helicase A (RHA), an interaction partner of WRN, was also present in the ..
  11. Roy B, Hu J, Guo X, Russell R, Guo F, Kleiman L, et al. Association of RNA helicase a with human immunodeficiency virus type 1 particles. J Biol Chem. 2006;281:12625-35 pubmed
    b>RNA helicase A (RHA) belongs to the DEAH family of proteins that are capable of unwinding double-stranded RNA structure...
  12. Friedemann J, Grosse F, Zhang S. Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity. J Biol Chem. 2005;280:31303-13 pubmed
    b>Nuclear DNA helicase II (NDH II), alternatively named RNA helicase A, is involved in transcription and RNA processing...
  13. Zhang S, Schlott B, Görlach M, Grosse F. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Nucleic Acids Res. 2004;32:1-10 pubmed
    An RNA-dependent association of Ku antigen with nuclear DNA helicase II (NDH II), alternatively named RNA helicase A (RHA), was found in nuclear extracts of HeLa cells by immunoprecipitation and by gel filtration chromatography...
  14. Zhang S, Grosse F. Domain structure of human nuclear DNA helicase II (RNA helicase A). J Biol Chem. 1997;272:11487-94 pubmed
    Full-length human nuclear DNA helicase II (NDH II) was cloned and overexpressed in a baculovirus-derived expression system. Recombinant NDH II unwound both DNA and RNA...
  15. Lee C, da Costa Soares V, Newberger C, Manova K, Lacy E, Hurwitz J. RNA helicase A is essential for normal gastrulation. Proc Natl Acad Sci U S A. 1998;95:13709-13 pubmed
    b>RNA helicase A (RHA) is the human homologue of the Drosophila maleless protein, an essential factor for the development of male flies...
  16. Zhang S, Herrmann C, Grosse F. Pre-mRNA and mRNA binding of human nuclear DNA helicase II (RNA helicase A). J Cell Sci. 1999;112 ( Pt 7):1055-64 pubmed
    b>Nuclear DNA helicase II (NDH II), alternatively named RNA helicase A, seems to function as a pre-mRNA and mRNA binding protein in human cells...
  17. Reddy T, Tang H, Xu W, Wong Staal F. Sam68, RNA helicase A and Tap cooperate in the post-transcriptional regulation of human immunodeficiency virus and type D retroviral mRNA. Oncogene. 2000;19:3570-5 pubmed
    ..Two CTE-binding proteins, RNA helicase A (RHA) and Tap, have been implicated in the nuclear export of CTE-containing RNA...
  18. Fuchsova B, Novak P, Kafková J, Hozak P. Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies. J Cell Biol. 2002;158:463-73 pubmed
    It is known that nuclear DNA helicase II (NDH II) links CREB-binding protein directly to RNA polymerase II holoenzyme, and that this interaction is essential for gene activation by CREB...
  19. Zhou K, Choe K, Zaidi Z, Wang Q, Mathews M, Lee C. RNA helicase A interacts with dsDNA and topoisomerase IIalpha. Nucleic Acids Res. 2003;31:2253-60 pubmed
    b>RNA helicase A (RHA) is a multifunctional protein involved in various nuclear processes such as transcription and RNA export...
  20. Hartman T, Qian S, Bolinger C, Fernandez S, Schoenberg D, Boris Lawrie K. RNA helicase A is necessary for translation of selected messenger RNAs. Nat Struct Mol Biol. 2006;13:509-16 pubmed
    b>RNA helicase A (RHA) is a highly conserved DEAD-box protein that activates transcription, modulates RNA splicing and binds the nuclear pore complex...
  21. Manojlovic Z, Stefanovic B. A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs. RNA. 2012;18:321-34 pubmed publisher
    ..Here we show that RNA helicase A (RHA) is tethered to the 5' SL of collagen mRNAs by interaction with the C-terminal domain of LARP6...
  22. Lin L, Li Y, Pyo H, Lu X, Raman S, Liu Q, et al. Identification of RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycle. J Virol. 2012;86:1942-54 pubmed publisher
    ..Among them, we focused our study on RNA helicase A (RHA) in this report...
  23. Zhang Z, Yuan B, Lu N, Facchinetti V, Liu Y. DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells. J Immunol. 2011;187:4501-8 pubmed publisher
    ..In this paper, we identified DHX9, a DExDc helicase family member, as an important viral dsRNA sensor in myeloid dendritic cells (mDCs)...
  24. Pellizzoni L, Charroux B, Rappsilber J, Mann M, Dreyfuss G. A functional interaction between the survival motor neuron complex and RNA polymerase II. J Cell Biol. 2001;152:75-85 pubmed
    ..By nanoelectrospray mass spectrometry, we identified RNA helicase A (RHA) as an SMN complex-associated protein...
  25. Mischo H, Hemmerich P, Grosse F, Zhang S. Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. J Biol Chem. 2005;280:9586-94 pubmed
    ..gamma-H2AX co-immunoprecipitated with Ku70, a subunit of DNA-dependent protein kinase, as well as with nuclear DNA helicase II (NDH II), a DEXH family helicase also known as RNA helicase A or DHX9...
  26. Chakraborty P, Grosse F. WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase. Nucleic Acids Res. 2010;38:4722-30 pubmed publisher
    ..WRN) that can engage in direct protein-protein interactions with DHX9, also known as RNA helicase A or nuclear DNA helicase II, which represents an essential enzyme involved in transcription and DNA repair...
  27. Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, et al. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA. 2009;15:104-15 pubmed publisher
    ..Four of these proteins (HNRNPU, SYNCRIP, YBX1, and DHX9) were essential to ensure stabilization of the c-myc mRNA via the CRD...
  28. Wang J, Reuschel E, Shackelford J, Jeang L, Shivers D, Diehl J, et al. HIV-1 Vif promotes the G?- to S-phase cell-cycle transition. Blood. 2011;117:1260-9 pubmed publisher
    ..These data suggest that Vif regulates early cell-cycle progression, with implications for infection and latency. ..
  29. Chen R, Jin C, Tong Z, Lu J, Tan L, Tian L, et al. Optimization extraction, characterization and antioxidant activities of pectic polysaccharide from tangerine peels. Carbohydr Polym. 2016;136:187-97 pubmed publisher
    ..mainly by α-glycosidic bonds, consisted of galacturonic acid (GalA), arabinose (Ara), galactose (Gal), rhamnose (Rha), glucose (Glc) and mannose (Man) with the average molecular weight of 17...
  30. Sand Dejmek J, Adelmant G, Sobhian B, Calkins A, Marto J, Iglehart D, et al. Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin. Mol Cancer. 2011;10:74 pubmed publisher
    ..Silencing FACT however, allows both apoptosis and necrosis. Targeting DNA repair in cancer patients may have different therapeutic effects depending upon the roles played by factors targeted. ..
  31. Rahman M, Bagdassarian E, Ali M, McFadden G. Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells. Sci Rep. 2017;7:15710 pubmed publisher
    ..Five host RNA helicases (DDX3X, DDX5, DHX9, DHX37, DDX52) were inhibitory for optimal replication and thus classified as anti-viral, while three other ..
  32. March G, Elfatori S, Beaule P. Clinical experience with tranexamic acid during primary total hip arthroplasty. Hip Int. 2013;23:72-9 pubmed publisher
    ..and 3) perioperative blood loss following primary total hip arthroplasty (THA) and resurfacing hip arthroplasty (RHA). One hundred and thirty-two patients (88 THA, 44 RHA; 66M, 66F; mean age = 58...
  33. Shiohama A, Sasaki T, Noda S, Minoshima S, Shimizu N. Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins. Exp Cell Res. 2007;313:4196-207 pubmed
    ..Thus, our studies provided additional new evidence for the involvement of various protein complexes in the molecular mechanisms of apparently complex innate RNA interference machinery. ..
  34. Pogliacomi F, Schiavi P, Pedrazzini A, Nosenzo A, Tocco S, Ceccarelli F. Modified Mason type III and IV radial head fractures: results of different surgical treatments. Acta Biomed. 2015;86:242-50 pubmed
    ..In 34 patients open reduction and internal fixation (ORIF) was used, in 20 radial head arthroplasty (RHA) was the treatment choice and radial head resection (RHR) was done in the remaining 9...
  35. Nguyen N, Chen S, Nguyen N, Nguyen H, Tsai H, Chang C. Adsorption of Methyl Blue on Mesoporous Materials Using Rice Husk Ash as Silica Source. J Nanosci Nanotechnol. 2016;16:4108-14 pubmed
    ..In this research, the adsorption of methyl blue (MB) using waste rice husk ash (Rha) and mesoporous silica materials made from Rha (R-MCM) were analyzed...
  36. Hiney J, Srivastava V, Vaden Anderson D, Hartzoge N, DEES W. Regulation of kisspeptin synthesis and release in the preoptic/anterior hypothalamic region of prepubertal female rats: actions of IGF-1 and alcohol. Alcohol Clin Exp Res. 2017;: pubmed publisher
    ..IGF-1 may be an upstream mediator of Kp in the preoptic area and rostral hypothalamic area (POA/RHA) of the rat brain, a region containing both Kp and LHRH neurons...
  37. Zhang C, Gao Z, Hu C, Zhang J, Sun X, Rong C, et al. Antioxidant, antibacterial and anti-aging activities of intracellular zinc polysaccharides from Grifola frondosa SH-05. Int J Biol Macromol. 2017;95:778-787 pubmed publisher
    ..The IZPS with higher bioactivities was composed of were Rha, Ino and Glu with a molar ratio of 4.7:3.6:1...
  38. Yilmazer Hanke D, Eliava M, Hanke J, Schwegler H, Asan E. Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats. Neurosci Lett. 2016;632:114-8 pubmed publisher
    ..Roman High- (RHA) and Low-Avoidance (RLA) rats are an ideal model to study the potential impact of this innervation on behavioral ..
  39. Robert Paganin J, Halladjian M, Blaud M, Lebaron S, Delbos L, Chardon F, et al. Functional link between DEAH/RHA helicase Prp43 activation and ATP base binding. Nucleic Acids Res. 2017;45:1539-1552 pubmed publisher
    The DEAH box helicase Prp43 is a bifunctional enzyme from the DEAH/RHA helicase family required both for the maturation of ribosomes and for lariat intron release during splicing...
  40. Gharekhani H, Olad A, Mirmohseni A, Bybordi A. Superabsorbent hydrogel made of NaAlg-g-poly(AA-co-AAm) and rice husk ash: Synthesis, characterization, and swelling kinetic studies. Carbohydr Polym. 2017;168:1-13 pubmed publisher
    The sodium alginate-g-poly(acrylic acid-co-acrylamide)/rice husk ash (NaAlg-g-P(AA-co-AAm)/RHA) superabsorbent nanocomposite was synthesized by the free-radical graft copolymerization of alginate (NaAlg), acrylic acid (AA), acrylamide (..
  41. Lee T, Pelletier J. Dependence of p53-deficient cells on the DHX9 DExH-box helicase. Oncotarget. 2017;8:30908-30921 pubmed publisher
    b>DHX9 is a DExH-box helicase family member with key regulatory roles in a broad range of cellular processes...
  42. Yu J, Xu Q, Wang Z, Yang Y, Zhang L, Ma J, et al. Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. J Hepatol. 2018;68:1214-1227 pubmed publisher
    ..Our in vitro and in vivo data showed that cSMARCA5 inhibits the growth and migration of hepatocellular carcinoma cells, making it a potential therapeutic target. ..
  43. Chatel Chaix L, Melan on P, Racine M, Baril M, Lamarre D. Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production. J Virol. 2011;85:11022-37 pubmed publisher
    ..Our data support that HCV hijacks YB-1-containing ribonucleoparticles and that YB-1-NS3/4A-HCV RNA complexes regulate the equilibrium between HCV RNA replication and viral particle production...
  44. Su D, Zhang R, Hou F, Chi J, Huang F, Yan S, et al. Lychee pulp phenolics ameliorate hepatic lipid accumulation by reducing miR-33 and miR-122 expression in mice fed a high-fat diet. Food Funct. 2017;8:808-815 pubmed publisher
    ..Quercetin 3-O-rutinoside-7-O-?-l-rhamnosidase (quercetin 3-rut-7-rha), rutin and (-)-epicatechin are the main phenolics in lychee (Litchi chinensis Sonn.) pulp...
  45. Treanor J, Chu L, Essink B, Muse D, El Sahly H, Izikson R, et al. Stable emulsion (SE) alone is an effective adjuvant for a recombinant, baculovirus-expressed H5 influenza vaccine in healthy adults: A Phase 2 trial. Vaccine. 2017;35:923-928 pubmed publisher
    ..Healthy subjects 18-49years old were randomized (1:1:1:1) to receive two doses of rHA at 7.5ug per dose (no adjuvant), or 3.8ug, 7...
  46. Dunn J, Kusnezov N, Koehler L, Eisenstein E, Kilcoyne K, Orr J, et al. Radial Head Arthroplasty in the Active Duty Military Service Member With Minimum 2-Year Follow-Up. J Hand Surg Am. 2017;42:660.e1-660.e7 pubmed publisher
    Radial head arthroplasty (RHA) is a viable treatment for complex radial head fracture...
  47. Arabahmadi V, Ghorbani M. Surface modified polythiophene nanocomposite using HPC and DBSNa for heavy metal ion removal. Water Sci Technol. 2017;75:2765-2776 pubmed publisher
    In the present work, surface modified nanocomposite adsorbents polythiophene (PTh)/rice husk ash (RHA) have successfully been synthesized in the presence of hydroxyl propyl cellulose (HPC) and sodium dodecyl benzene sulfonate (DBSNa) as ..
  48. Gimenez Llort L, Guitart Masip M, Tobeña A, Fernández Teruel A, Johansson B. Distinct phenotypes of spontaneous activity and induction of amphetamine sensitization in inbred Roman high- and low-avoidance rats: Vulnerability and protection. Neurosci Lett. 2018;673:92-98 pubmed publisher
    The psychogenetically selected Roman high- (RHA) and low-avoidance (RLA) rats are being proposed as a valuable animal model of individual vulnerability to the two distinct neurobiological mechanisms of behavioral sensitization to ..
  49. Wang C, Feng L, Su J, Cui L, Dan Liu -, Yan J, et al. Polysaccharides from Epimedium koreanum Nakai with immunomodulatory activity and inhibitory effect on tumor growth in LLC-bearing mice. J Ethnopharmacol. 2017;207:8-18 pubmed publisher
    ..Results showed that EPS (180 × 104Da) was composed of mannose (Man), rhamnose (Rha), glucuronic acid (GlcUA), galactosamine (GalN), glucose (Glc), galactose (Gal), arabinose (Ara) and fructose (Fuc)...
  50. Smith W, Schurter B, Wong Staal F, David M. Arginine methylation of RNA helicase a determines its subcellular localization. J Biol Chem. 2004;279:22795-8 pubmed
    b>RNA helicase A (RHA) undergoes nuclear translocation via a classical import mechanism utilizing karyopherin beta. The nuclear transport domain (NTD) of RHA is known to be necessary and sufficient for its bi-directional nuclear trafficking...
  51. Xing L, Niu M, Zhao X, Kleiman L. Different activities of the conserved lysine residues in the double-stranded RNA binding domains of RNA helicase A in vitro and in the cell. Biochim Biophys Acta. 2014;1840:2234-43 pubmed publisher
    b>RNA helicase A regulates a variety of RNA metabolism processes including HIV-1 replication and contains two double-stranded RNA binding domains (dsRBD1 and dsRBD2) at the N-terminus...
  52. Takasaki Y, Kogure T, Takeuchi K, Kaneda K, Yano T, Hirokawa K, et al. Reactivity of anti-proliferating cell nuclear antigen (PCNA) murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation. J Immunol. 2001;166:4780-7 pubmed
  53. Capitanio J, Montpetit B, Wozniak R. Nucleoplasmic Nup98 controls gene expression by regulating a DExH/D-box protein. Nucleus. 2017;:1-8 pubmed publisher
    ..sup>4-6 Analysis of Nup98 and one of these DBPs, DHX9, showed that they directly interact, their association is facilitated by RNA, and Nup98 binding stimulates DHX9 ..
  54. Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm N, et al. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017;546:667-670 pubmed publisher
    ..Our data show that, via RNA helicase Dhx9, Nlrp9b recognizes short double-stranded RNA stretches and forms inflammasome complexes with the adaptor proteins ..
  55. Wang Q, Zhang Z, Blackwell K, Carmichael G. Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin. Curr Biol. 2005;15:384-91 pubmed
    ..Furthermore, nuclear Vigilin is found in complexes containing not only the editing enzyme ADAR1 but also RNA helicase A and Ku86/70...
  56. Fuchsova B, Hozak P. The localization of nuclear DNA helicase II in different nuclear compartments is linked to transcription. Exp Cell Res. 2002;279:260-70 pubmed
    b>Nuclear DNA helicase II (NDH II) is a member of the DEAH superfamily of helicases and functions as a pre-mRNA- and mRNA-binding protein in human cells...
  57. Kean R, Johnson R, Doyle M. Code Grey: Stained Surgical Instruments and Their Impact on One Canadian Health Authority. Healthc Q. 2017;20:65-68 pubmed
    In 2016, NL's largest RHA was faced with serious challenges stemming from the discovery of stained surgical instruments at its two largest hospitals...
  58. El Hajj I, Sherman S, Pyko M, Lehman G. Life threatening hemobilia after endoscopic retrograde cholangiopancreatography (ERCP). Dig Liver Dis. 2017;49:1336-1337 pubmed publisher
    ..This report describes a life threatening hemobilia, from a pseudoaneurysm of the right hepatic artery (RHA), which occurred post ERCP...
  59. Laumonerie P, Reina N, Ancelin D, Delclaux S, Tibbo M, Bonnevialle N, et al. Mid-term outcomes of 77 modular radial head prostheses. Bone Joint J. 2017;99-B:1197-1203 pubmed publisher
    Radial head arthroplasty (RHA) may be used in the treatment of non-reconstructable radial head fractures. The aim of this study was to evaluate the mid-term clinical and radiographic results of RHA...
  60. Ravenscroft N, Omar A, Hlozek J, Edmonds Smith C, Follador R, Serventi F, et al. Genetic and structural elucidation of capsular polysaccharides from Streptococcus pneumoniae serotype 23A and 23B, and comparison to serotype 23F. Carbohydr Res. 2017;450:19-29 pubmed publisher
    ..differs from polysaccharide 23F as it features a disaccharide backbone and the di-substituted ?-Gal is linked to ?-Rha as a side chain...
  61. Xu W, Lo T, Wang W, Ouyang D, Wang P, Xing F. Pozzolanic Reactivity of Silica Fume and Ground Rice Husk Ash as Reactive Silica in a Cementitious System: A Comparative Study. Materials (Basel). 2016;9: pubmed publisher
    This study comparably assessed the pozzolanic effect of silica fume (SF) and ground rice husk ash (RHA) as supplementary cementing materials on the properties of blended cement pastes and concretes...
  62. Ochem A, Rechreche H, Skopac D, Falaschi A. Stimulation of the DNA unwinding activity of human DNA helicase II/Ku by phosphorylation. Arch Biochem Biophys. 2008;470:1-7 pubmed
    ..In vitro dephosphorylation of HeLa cellular HDH II/Ku caused a significant decrease in the DNA helicase activity of this enzyme. ..
  63. Wang M, Arbatsky N, Xu L, Shashkov A, Wang L, Knirel Y. O antigen of FranconibacterpulverisG3872 (O1) is a 4-deoxy-d-arabino-hexose-containing polysaccharide synthesized by the ABC-transporter-dependent pathway. Microbiology. 2016;162:1103-13 pubmed publisher
    ..Studies by sugar analysis and NMR spectroscopy showed that the OPS contained d-ribose, l-rhamnose (l-Rha) and a rarely occurring monosaccharide 4-deoxy-d-arabino-hexose, and the OPS structure was established...
  64. Prahl M, Vilborg A, Palmberg C, Jornvall H, Asker C, Wiman K. The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA. FEBS Lett. 2008;582:2173-7 pubmed publisher
    ..Using co-immunoprecipitation and mass spectrometry, we identified two Wig-1-binding proteins, hnRNP A2/B1 and RNA Helicase A, both of which are involved in RNA processing. The binding was dependent on the presence of RNA...
  65. Lai M, Lee Y, Tarn W. The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control. Mol Biol Cell. 2008;19:3847-58 pubmed publisher
    ..Given that the DDX3 RNA helicase activity is essential for its involvement in translation, we suggest that DDX3 facilitates translation by resolving secondary structures of the 5'-untranslated region in mRNAs during ribosome scanning. ..
  66. Suhasini M, Reddy T. Cellular proteins and HIV-1 Rev function. Curr HIV Res. 2009;7:91-100 pubmed
    ..Therefore, we will here focus on other Rev cofactors (eIF5a, hRIP, Sam68, RNA helicases, etc) and the role they play in Rev/RRE function and HIV-1 replication. ..
  67. Guenard F, Labrie Y, Ouellette G, Beauparlant C, Durocher F. Genetic sequence variations of BRCA1-interacting genes AURKA, BAP1, BARD1 and DHX9 in French Canadian families with high risk of breast cancer. J Hum Genet. 2009;54:152-61 pubmed publisher
    ..spliced mRNA species were identified, a total of 10, 4, 11 and 6 variants were found in the AURKA, BAP1, BARD1 and DHX9 genes, respectively...
  68. Oliveras I, Sánchez González A, Sampedro Viana D, Piludu M, Río Alamos C, Giorgi O, et al. Differential effects of antipsychotic and propsychotic drugs on prepulse inhibition and locomotor activity in Roman high- (RHA) and low-avoidance (RLA) rats. Psychopharmacology (Berl). 2017;234:957-975 pubmed publisher
    ..We have carried out a pharmacological characterization of the Roman high- (RHA-I) and low-avoidance (RLA-I) rat strains with different acutely administered propsychotic (DOI, MK-801) and ..
  69. Xing L, Niu M, Zhao X, Kleiman L. Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism. PLoS ONE. 2013;8:e78596 pubmed publisher
    b>RNA helicase A (RHA) promotes multiple steps in HIV-1 production including transcription and translation of viral RNA, annealing of primer tRNA(Lys3) to viral RNA, and elevating the ratio of unspliced to spliced viral RNA...
  70. Chen Z, Wallis K, Fell S, Sobrado V, Hemmer M, Ramsköld D, et al. RNA helicase A is a downstream mediator of KIF1B? tumor-suppressor function in neuroblastoma. Cancer Discov. 2014;4:434-51 pubmed publisher
    ..However, the mechanism of tumor suppression is unknown. We found that KIF1B isoform ? (KIF1B?) interacts with RNA helicase A (DHX9), causing nuclear accumulation of DHX9, followed by subsequent induction of the proapoptotic XIAP-..
  71. Kim J, Gonzalez Heredia R, Daskalaki D, Rashdan M, Masrur M, Giulianotti P. Totally replaced right hepatic artery in pancreaticoduodenectomy: is this anatomical condition a contraindication to minimally invasive surgery?. HPB (Oxford). 2016;18:580-5 pubmed publisher
    The appropriate approach, in the case of an aberrant right hepatic artery (RHA) during open pancreaticoduodenectomy (PD), has already been established...
  72. Tang W, You W, Shi F, Qi T, Wang L, Djouder Z, et al. RNA helicase A acts as a bridging factor linking nuclear beta-actin with RNA polymerase II. Biochem J. 2009;420:421-8 pubmed publisher
    ..In the present study, we identified RHA (RNA helicase A) as an actin-interacting protein in PICs...
  73. Jørgensen O, Haakenstad B, Ovesen O, Overgaard S. [Clinical outcome, complications and prosthesis survival in patients operated with hip resurfacing arthroplasty]. Ugeskr Laeger. 2017;179: pubmed
    Hip resurfacing arthroplasty (RHA) was introduced as a superior alternative to the standard total hip arthroplasty (THA) in treating younger, more active patients...
  74. Xing L, Niu M, Kleiman L. Role of the OB-fold of RNA helicase A in the synthesis of HIV-1 RNA. Biochim Biophys Acta. 2014;1839:1069-78 pubmed publisher
    b>RNA helicase A (RHA), a DExD/H protein, contains a stretch of repeated arginine and glycine-glycine (RGG) residues and an oligonucleotide/oligosaccharide-binding fold (OB-fold) at the C-terminus...
  75. Välineva T, Yang J, Silvennoinen O. Characterization of RNA helicase A as component of STAT6-dependent enhanceosome. Nucleic Acids Res. 2006;34:3938-46 pubmed
    ..Here, we describe RNA helicase A (RHA) as a novel component of STAT6 transcriptosome...
  76. Wu F, Zhou C, Zhou D, Ou S, Zhang X, Huang H. Structure characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its immunomodulatory activities. Food Funct. 2018;9:294-306 pubmed publisher
    ..linkage types of HEP-S were composed of (1?)-?-d-Glc, (1?3,4)-?-d-Glc, (1?6)-?-d-Gal, (1?3,4)-?-d-Man, (1?3,6)-?-Rha and (1?2)-?-l-Fuc...
  77. Fidaleo M, Svetoni F, Volpe E, Miñana B, Caporossi D, Paronetto M. Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9. Oncotarget. 2015;6:31740-57 pubmed publisher
    ..In particular, irradiation induces a new isoform of the RNA helicase DHX9 in the more sensitive SK-N-MC cells, which is targeted to nonsense-mediated decay (NMD), causing its downregulation...