Gene Symbol: DHX58
Description: DExH-box helicase 58
Alias: D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH (Asp-Glu-X-His) box polypeptide 58, RIG-I-like receptor 3, RIG-I-like receptor LGP2, RLR, RNA helicase LGP2, ortholog of mouse D11lgp2, protein D11Lgp2 homolog
Species: human
Products:     DHX58

Top Publications

  1. Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira K, et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol. 2005;175:2851-8 pubmed
    ..Another protein, LGP2, lacks the CARD homology and functions as a negative regulator by interfering with the recognition of viral RNA by ..
  2. Komuro A, Horvath C. RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. J Virol. 2006;80:12332-42 pubmed
    ..Another helicase protein, LGP2, lacks the CARD region and does not activate IFN-beta gene expression...
  3. Saito T, Hirai R, Loo Y, Owen D, Johnson C, Sinha S, et al. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A. 2007;104:582-7 pubmed
    ..We also found that LGP2, a helicase related to RIG-I and MDA5 but lacking CARDs and functioning as a negative regulator of host defense, ..
  4. Murali A, Li X, Ranjith Kumar C, Bhardwaj K, Holzenburg A, Li P, et al. Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response. J Biol Chem. 2008;283:15825-33 pubmed publisher
    ..b>LGP2, a homolog of RIG-I and MDA5 without the caspase recruitment domain required for signaling, plays an important role ..
  5. Childs K, Randall R, Goodbourn S. LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. PLoS ONE. 2013;8:e64202 pubmed publisher
    ..Laboratory of genetics and physiology 2 (LGP2) is thought to influence IFN production by regulating the activity of RIG-I and mda-5, although its mechanism of ..
  6. Li X, Ranjith Kumar C, Brooks M, Dharmaiah S, Herr A, Kao C, et al. The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. J Biol Chem. 2009;284:13881-91 pubmed publisher
    ..b>LGP2, a homolog of RIG-I and MDA5 that lacks signaling capability, regulates the signaling of the RLRs...
  7. Parisien J, Bamming D, Komuro A, Ramachandran A, Rodriguez J, Barber G, et al. A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2. J Virol. 2009;83:7252-60 pubmed publisher
    ..identified approximately 130-residue region is highly homologous between MDA5 and the related antiviral helicase LGP2, but not RIG-I. Results indicate that the paramyxovirus V proteins can also associate with LGP2...
  8. Bruns A, Pollpeter D, Hadizadeh N, Myong S, Marko J, Horvath C. ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2). J Biol Chem. 2013;288:938-46 pubmed publisher
    Laboratory of genetics and physiology 2 (LGP2) is a member of the RIG-I-like receptor family of cytoplasmic pattern recognition receptors that detect molecular signatures of virus infection and initiate antiviral signal transduction ..
  9. Childs K, Randall R, Goodbourn S. Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction. J Virol. 2012;86:3411-21 pubmed publisher
    ..Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD domains required for signaling...

More Information


  1. Liu H, Zhu Z, Xue Q, Yang F, Cao W, Zhang K, et al. Foot-and-mouth disease virus antagonizes NOD2-mediated antiviral effects by inhibition of NOD2 protein expression. J Virol. 2019;: pubmed publisher
    ..Our previous studies determined that FMDV 2B suppressed protein expression of RIG-I and LGP2. Here, we found that 3Cpro and 2B also decreased NOD2 expression...
  2. Zhou L, Sun S, Xu L, Yu Y, Zhang T, Wang M. DExH-Box helicase 58 enhances osteoblast differentiation of osteoblastic cells via Wnt/β-Catenin signaling. Biochem Biophys Res Commun. 2019;511:307-311 pubmed publisher
    ..In this study, we supposed DHX58 may have a close relationship with osteogenesis and we then detected the expression of DHX58 during osteogenesis...
  3. Pottier C, Ren Y, Perkerson R, Baker M, Jenkins G, van Blitterswijk M, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol. 2019;: pubmed publisher
    ..g., DHX58, TRIM21, IRF7) in the genetic etiology of FTLD-TDP...
  4. She M, Jiang H, Chen X, Chen X, Liu X, Zhang X, et al. GADD45γ Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes. J Virol. 2019;93: pubmed publisher
    ..by this laboratory to be activated concurrently with significantly reduced virus yields in cells depleted of LGP2 or HDAC4...
  5. Gu T, Lu L, An C, Chen B, Wei W, Wu X, et al. MDA5 and LGP2 acts as a key regulator though activating NF-κB and IRF3 in RLRs signaling of mandarinfish. Fish Shellfish Immunol. 2019;86:1114-1122 pubmed publisher
    ..in the immune responses of mandarinfish (Siniperca chuatsi), by evaluating three RLRs, namely, RIG-I, MDA5, and LGP2. The results revealed that MDA5 and LGP2 were present in mandarinfish, whereas RIG-I was absent...
  6. Lai Y, Liang M, Hu L, Zeng Z, Lin H, Yi G, et al. RNF135 is a positive regulator of IFN expression and involved in RIG-I signaling pathway by targeting RIG-I. Fish Shellfish Immunol. 2019;86:474-479 pubmed publisher
    ..Furthermore, the expression profiles of RIG-I signaling pathway related genes (LGP2, MDA5, RIG-I, MAVS, TRAF3, IRF3 and IRF7), together with its downstream molecules (IFN1, ISG15, Mx and PKR), were ..
  7. Lin L, Huang C, Wu M, Hsu W, Chuang J. Innate immune sensor laboratory of genetics and physiology 2 suppresses tumor cell growth and functions as a prognostic marker in neuroblastoma. Cancer Sci. 2018;109:3494-3502 pubmed publisher
    ..However, the role of another important innate immune cytosolic sensor, laboratory of genetics and physiology 2 (LGP2), in the cancer behavior of NB remains unclear...
  8. Saruwatari J, Dong C, Utsumi T, Tanaka M, McConnell M, Iwakiri Y. Integrated analysis of microRNA and mRNA expression profiles in splenomegaly induced by non-cirrhotic portal hypertension in rats. Sci Rep. 2018;8:17983 pubmed publisher
    ..g., irf7, dhx58)...
  9. Corby M, Raicu V, Frick D. New Techniques to Study Intracellular Receptors in Living Cells: Insights Into RIG-I-Like Receptor Signaling. Adv Exp Med Biol. 2018;: pubmed publisher
    ..unknown RNA mitochondrial receptor orientations, and the interaction between the viral RNA receptor called LGP2 with the RNA helicase encoded by the hepatitis virus...
  10. Zheng W, Satta Y. Functional Evolution of Avian RIG-I-Like Receptors. Genes (Basel). 2018;9: pubmed publisher
    ..melanoma differentiation-associated gene 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2)...
  11. Takahashi T, Nakano Y, Onomoto K, Yoneyama M, Ui Tei K. Virus Sensor RIG-I Represses RNA Interference by Interacting with TRBP through LGP2 in Mammalian Cells. Genes (Basel). 2018;9: pubmed publisher
    ..Laboratory of genetics and physiology 2 (LGP2) is one of the RLRs, but its function has remained unclear...
  12. Parisien J, Lenoir J, Mandhana R, Rodriguez K, Qian K, Bruns A, et al. RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling. EMBO Rep. 2018;19: pubmed publisher
    ..Data indicate that a third RNA receptor, LGP2, acts as a negative regulator of antiviral signaling by interfering with TRAF family proteins...
  13. Fan X, Dong S, Li Y, Ding S, Wang M. RIG-I-dependent antiviral immunity is effective against an RNA virus encoding a potent suppressor of RNAi. Biochem Biophys Res Commun. 2015;460:1035-40 pubmed publisher
    ..for NoV infection, here we show that MEFs derived from mice knockout for RIG-I, but not those knockout for MDA5, LGP2, TLR3 or TLR7, exhibited an enhanced susceptibility to NoV...
  14. Foronjy R, Dabo A, Cummins N, Geraghty P. Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection. BMC Immunol. 2014;15:41 pubmed publisher
    ..cytokines than melanoma differentiation-associated protein 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2), and Trif expression...
  15. Jiao P, Wei L, Song Y, Cui J, Zhang S, Han F, et al. Molecular cloning and immune responsive expression of LGP2 gene, a pivotal member of the RLR gene family from Muscovy duck Cairina moschata. Poult Sci. 2015;94:1170-6 pubmed publisher
    Laboratory of genetics and physiology 2 (LGP2) is an important intracellular receptor that recognizes viral RNAs in innate immunity. In this study, a novel LGP2 cDNA was identified from the spleen of a Muscovy duck (Cairina moschata)...
  16. Hamonic G, Pasternak J, Forsberg N, Käser T, Wilson H. Expression of pattern recognition receptors in porcine uterine epithelial cells in vivo and in culture. Vet Immunol Immunopathol. 2018;202:1-10 pubmed publisher
    ..cells (in vivo and in vitro) were shown to express TLR1-7, TLR9, NOD1, NOD2, NLRP3, NLRP6, NLRX1, RIG1, MDA5 and LGP2. Subcellular localization of in vivo and polarized primary UECs exhibited TLR3 and TLR9 localized to the apical ..
  17. Liu M, Wu T, Li S, Wei P, Yan Y, Gu W, et al. Combined transcriptomic/proteomic analysis of crucian carp Carassius auratus gibelio in cyprinid herpesvirus 2 infection. Fish Shellfish Immunol. 2018;82:386-399 pubmed publisher
    ..selected for qRT-PCR to confirm the validity of the transcriptome and proteome changes by showing that RIG-I, MDA5, LGP2, FAS, PKR and PKZ up-regulated and Integrin α, Integrin β2, NCF2 and NCF4 down-regulated...
  18. Mou C, Wang Y, Zhang Q, Gao F, Li Z, Tong J, et al. Differential interferon system gene expression profiles in susceptible and resistant gynogenetic clones of gibel carp challenged with herpesvirus CaHV. Dev Comp Immunol. 2018;86:52-64 pubmed publisher
    ..this study, we first identified multiple transcripts of 15 IFN system genes, including PRRs (TLR2, TLR3, RIG-I, and LGP2), PRR-mediated IFN signal pathway (MyD88, MITA, and MAVS), IFN regulatory factors (IRF1, IRF3, IRF7, and IRF9), ..
  19. Gao F, Lu M, Wang M, Liu Z, Ke X, Zhang D, et al. Molecular characterization and function analysis of three RIG-I-like receptor signaling pathway genes (MDA5, LGP2 and MAVS) in Oreochromis niloticus. Fish Shellfish Immunol. 2018;82:101-114 pubmed publisher
    ..In the present study, we isolated the full-length cDNA and genomic DNA sequences of the MDA5, LGP2 and MAVS genes in Nile tilapia, termed OnMDA5, OnLGP2 and OnMAVS...
  20. Chen X, Yang C, Su J, Rao Y, Gu T. LGP2 plays extensive roles in modulating innate immune responses in Ctenopharyngodon idella kidney (CIK) cells. Dev Comp Immunol. 2015;49:138-48 pubmed publisher
    b>LGP2 (laboratory of genetics and physiology 2), RIG-I (retinoic acid inducible gene-I) and MDA5 (melanoma differentiation associated gene 5) constitute the RLR (RIG-I-like receptor) family...
  21. Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S. Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol Cell. 2016;62:586-602 pubmed publisher
    ..Non-signaling LGP2 appears to positively and negatively regulate MDA5 and RIG-I signaling, respectively...
  22. Takahashi T, Nakano Y, Onomoto K, Murakami F, Komori C, Suzuki Y, et al. LGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs. Nucleic Acids Res. 2018;46:9134-9147 pubmed publisher
    Here we show that laboratory of genetics and physiology 2 (LGP2) virus sensor protein regulates gene expression network of endogenous genes mediated by TAR-RNA binding protein (TRBP)-bound microRNAs (miRNAs)...
  23. Xu L, Yu D, Fan Y, Peng L, Wu Y, Yao Y. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proc Natl Acad Sci U S A. 2016;113:10950-5 pubmed publisher
    The function of the RIG-I-like receptors (RLRs; including RIG-I, MDA5, and LGP2) as key cytoplasmic sensors of viral pathogen-associated molecular patterns (PAMPs) has been subjected to numerous pathogenic challenges and has undergone a ..
  24. Eslamloo K, Xue X, Booman M, Smith N, Rise M. Transcriptome profiling of the antiviral immune response in Atlantic cod macrophages. Dev Comp Immunol. 2016;63:187-205 pubmed publisher
    ..g. tlr3, tlr7, mda5 and lgp2), as well as signal transducers (e.g. stat1 and nfkbia) and transcription activators (e.g...
  25. Jia P, Zhang J, Jin Y, Zeng L, Jia K, Yi M. Characterization and expression analysis of laboratory of genetics and physiology 2 gene in sea perch, Lateolabrax japonicus. Fish Shellfish Immunol. 2015;47:214-20 pubmed publisher
    b>LGP2 (laboratory of genetics and physiology 2) as a key component of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), plays a predominant role in modulating RLRs-mediated cellular antiviral signaling during viral ..
  26. Caballero I, Honko A, Gire S, Winnicki S, Mele M, Gerhardinger C, et al. In vivo Ebola virus infection leads to a strong innate response in circulating immune cells. BMC Genomics. 2016;17:707 pubmed publisher
    ..early increases in expression were interferon-stimulated genes, such as ISG15, OAS1, IFIT2, HERC5, MX1 and DHX58. Other highly upregulated genes included cytokines CXCL11, CCL7, IL2RA, IL2R1, IL15RA, and CSF2RB, which have not ..
  27. Sayed N, Ospino F, Himmati F, Lee J, Chanda P, Mocarski E, et al. Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming. Stem Cells. 2017;35:1197-1207 pubmed publisher
    ..This pathway is represented by the sensors of viral RNA, RIG-1, LGP2, and melanoma differentiation-associated protein 5 (MDA5)...
  28. He Y, Xie Z, Dai J, Cao Y, Hou J, Zheng Y, et al. Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks. Virol Sin. 2016;31:57-68 pubmed publisher
    ..Moreover, melanoma differentiation-associated protein 5 (MDA5), laboratory of genetics and physiology 2 (LGP2), stimulator of IFN genes (STING), and mitochondrial antiviral signaling protein (MAVS), as well as TANK binding ..
  29. Du J, Chen X, Wang C, Sun H. Pathway analysis of global gene expression change in dendritic cells induced by the polysaccharide from the roots of Actinidia eriantha. J Ethnopharmacol. 2018;214:141-152 pubmed publisher
    ..transcription factors (STAT1, STAT2, STAT5b, IRF1 and IRF7) and pattern recognition receptors (TLR3, DDX58, DHX58 and IFIH1) in the BMDCs...
  30. Wei L, Song Y, Cui J, Qu N, Wang N, Ouyang G, et al. Cloning, characterization, and expression analysis of LGP2 cDNA from goose, Anser cygnoides. Poult Sci. 2016;95:2290-6 pubmed publisher
    Laboratory of genetics and physiology 2 ( LGP2: ) is a homologue of the retinoic acid inducible gene-I and melanoma differentiation associated gene 5 that lacks the caspase activation and recruitment domain required for signaling...
  31. Yu Y, Huang Y, Yang Y, Wang S, Yang M, Huang X, et al. Negative regulation of the antiviral response by grouper LGP2 against fish viruses. Fish Shellfish Immunol. 2016;56:358-366 pubmed publisher
    Laboratory of genetics and physiology 2 (LGP2), a member of RIG-I like receptor (RLR) family, plays crucial roles in modulating cellular antiviral response during viral infection...
  32. Liu Y, Liu Y, Wu J, Roizman B, Zhou G. Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection. Proc Natl Acad Sci U S A. 2018;115:E3230-E3237 pubmed publisher
    Analyses of the levels of mRNAs encoding IFIT1, IFI16, RIG-1, MDA5, CXCL10, LGP2, PUM1, LSD1, STING, and IFN? in cell lines from which the gene encoding LGP2, LSD1, PML, HDAC4, IFI16, PUM1, STING, MDA5, IRF3, or HDAC 1 had been knocked ..
  33. Sanchez David R, Combredet C, Sismeiro O, Dillies M, Jagla B, Coppée J, et al. Comparative analysis of viral RNA signatures on different RIG-I-like receptors. elife. 2016;5:e11275 pubmed publisher
    ..To decipher the viral RNA signature on RLRs during viral infection, we tagged RLRs (RIG-I, MDA5, LGP2) and applied tagged protein affinity purification followed by next-generation sequencing (NGS) of associated RNA ..
  34. Ahmad S, Hur S. Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors. Trends Biochem Sci. 2015;40:576-85 pubmed publisher
    ..We will also discuss the closely related, but less understood, helicases, laboratory of genetics and physiology 2 (LGP2) and Dicer-related helicase-1 and -3 (DRH-1 and -3).
  35. Wahadat M, Bodewes I, Maria N, van Helden Meeuwsen C, van Dijk Hummelman A, Steenwijk E, et al. Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?. Arthritis Res Ther. 2018;20:4 pubmed publisher
    ..Upregulated gene expression of TLR7, RLRs (IFIH1, DDX58, DDX60, DHX58) and DBRs (ZBP-1, IFI16) was observed in CD14+ monocytes of the IFN-I-positive cSLE patients...
  36. Xiang B, Zhu W, Li Y, Gao P, Liang J, Liu D, et al. Immune responses of mature chicken bone-marrow-derived dendritic cells infected with Newcastle disease virus strains with differing pathogenicity. Arch Virol. 2018;163:1407-1417 pubmed publisher
    ..Gene expression profiling showed that MDA5, LGP2, TLR3, TLR7, IFN-?, IFN-?, IFN-?, IL-1?, IL-6, IL-18, IL-8, CCL5, IL-10, IL-12, MHC-I, and MHC-II levels were ..
  37. Xu C, Evensen Ø, Munang andu H. De Novo Transcriptome Analysis Shows That SAV-3 Infection Upregulates Pattern Recognition Receptors of the Endosomal Toll-Like and RIG-I-Like Receptor Signaling Pathways in Macrophage/Dendritic Like TO-Cells. Viruses. 2016;8:114 pubmed publisher
    ..gene I (RIG-I), melanoma differentiation association 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2)...
  38. Liao Z, Wan Q, Su H, Wu C, Su J. Pattern recognition receptors in grass carp Ctenopharyngodon idella: I. Organization and expression analysis of TLRs and RLRs. Dev Comp Immunol. 2017;76:93-104 pubmed publisher
    ..Meanwhile, RLR family consist of three conserved members (RIG-I, MDA5 and LGP2) as well as two adaptors (IPS-1 and STING) in C. idella...
  39. Liu S, Jiang C, Duan C, Hu L, Zhang S. Expression of virus-responsive genes and their response to challenge with poly(I:C) at different stages of the annual fish Nothobranchius guentheri: Implications for an asymmetric decrease in immunity. Fish Shellfish Immunol. 2015;46:493-500 pubmed publisher
    ..annual fish Nothobranchius guentheri, as reflected by the expression levels of virus-responsive genes, including lgp2 and mda5 encoding sensor molecules, ifn-i and viperin encoding the effector molecules and irf1, irf7, stat1 and ..
  40. Liu S, Liu Y, Yang S, Huang Y, Qin Q, Zhang S. Evolutionary conservation of molecular structure and antiviral function of a viral receptor, LGP2, in amphioxus Branchiostoma japonicum. Eur J Immunol. 2015;45:3404-16 pubmed publisher
    RIG-I-like (where RIG-I is retinoic acid inducible gene I) receptor LGP2 (where LGP2 is laboratory of genetics and physiology) is an important intracellular receptor that recognizes viral RNAs in innate immunity, but its origin and ..
  41. van der Veen A, Maillard P, Schmidt J, Lee S, Deddouche Grass S, Borg A, et al. The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells. EMBO J. 2018;37: pubmed publisher
    ..ISGs include the RLRs themselves: RIG-I, MDA5 and, the least-studied family member, LGP2. In contrast, the IFN system is absent in plants and invertebrates, which defend themselves from viral intruders ..
  42. Han J, Wang Y, Chu Q, Xu T. The evolution and functional characterization of miiuy croaker cytosolic gene LGP2 involved in immune response. Fish Shellfish Immunol. 2016;58:193-202 pubmed publisher
    The laboratory of genetics and physiology 2 (LGP2) is a member of retinoic acid-inducible gene I (RIG-I)-like receptors (RLR receptors), which may participate in the immune regulation process...
  43. Chu Q, Gao Y, Xu G, Wu C, Xu T. Transcriptome comparative analysis revealed poly(I:C) activated RIG-I/MDA5-mediated signaling pathway in miiuy croaker. Fish Shellfish Immunol. 2015;47:168-74 pubmed publisher
    ..In this pathway, both MDA5 and LGP2 are important RLRs in host surveillance against infection of dsRNA viruses and induce type I IFNs response which ..
  44. Bao Y, Gao Y, Shi Y, Cui X. Dynamic gene expression analysis in a H1N1 influenza virus mouse pneumonia model. Virus Genes. 2017;53:357-366 pubmed publisher
    ..pneumonia were revealed by dynamic gene network analysis, and the most important genes were filtered, including Dhx58, Cxcl10, Cxcl11, Zbp1, Ifit1, Ifih1, Trim25, Mx2, Oas2, Cd274, Irgm1, and Irf7...
  45. Xiao J, Yan J, Chen H, Li J, Tian Y, Feng H. LGP2 of black carp plays an important role in the innate immune response against SVCV and GCRV. Fish Shellfish Immunol. 2016;57:127-135 pubmed publisher
    ..In this paper, LGP2 of black carp (Mylopharyngodon piceus) has been cloned and characterized, which is a key member of RLR family...
  46. Shen B, Hu Y, Zhang S, Zheng J, Zeng L, Zhang J, et al. Molecular characterization and expression analyses of three RIG-I-like receptor signaling pathway genes (MDA5, LGP2 and MAVS) in Larimichthys crocea. Fish Shellfish Immunol. 2016;55:535-49 pubmed publisher
    ..The results indicate that the LcMDA5, LcLGP2 and LcMAVS might play important roles in antiviral immune responses. ..
  47. Ranoa D, Parekh A, Pitroda S, Huang X, Darga T, Wong A, et al. Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs. Oncotarget. 2016;7:26496-515 pubmed publisher
    ..We identified a novel radioprotective role for the DEXH box RNA helicase LGP2 (DHX58) through its suppression of IR-induced cytotoxic IFN-beta [1]...
  48. Zhu Z, Li C, Du X, Wang G, Cao W, Yang F, et al. Foot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication. Cell Death Dis. 2017;8:e2747 pubmed publisher
    The role of the innate immune protein LGP2 (laboratory of genetics and physiology 2) in FMDV-infected cells remains unknown. Here, we demonstrate the antiviral role of LGP2 during FMDV infection...
  49. Bruns A, Horvath C. LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling. Cytokine. 2015;74:198-206 pubmed publisher
    ..The RLR family is composed of three homologous proteins, RIG-I, MDA5, and LGP2. All RLRs have the ability to detect virus-derived dsRNA and hydrolyze ATP, but display individual differences in ..
  50. Mura M, Combredet C, Najburg V, Sanchez David R, Tangy F, Komarova A. Nonencapsidated 5' Copy-Back Defective Interfering Genomes Produced by Recombinant Measles Viruses Are Recognized by RIG-I and LGP2 but Not MDA5. J Virol. 2017;91: pubmed publisher
    ..DI-RNAs are pathogen-associated molecular patterns recognized by RIG-I-like receptors (RLRs) (RIG-I, MDA5, and LGP2) that activate innate immune signaling and shape the adaptive immune response...
  51. Bruns A, Leser G, Lamb R, Horvath C. The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Mol Cell. 2014;55:771-81 pubmed publisher
    ..One receptor, MDA5, possesses essential signaling domains, but weak RNA binding. A second receptor, LGP2, rapidly detects diverse dsRNA species, but lacks signaling domains...
  52. Miyamoto M, Komuro A. PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2. Biochem Biophys Res Commun. 2017;494:227-233 pubmed publisher
    Laboratory of genetics and physiology 2 (LGP2) and melanoma differentiation-associated gene 5 (MDA5) cooperatively detect viral RNA in the cytoplasm of Cardiovirus-infected cells and activate innate immune responses...
  53. Zhang Q, Zhao X, Li Z, Wu M, Gui J, Zhang Y. Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response. J Immunol. 2018;200:688-703 pubmed publisher
    ..differentiation-associated gene 5 (MDA5) sense cytosolic viral RNA, leading to IFN antiviral response; however, LGP2 exhibits controversial functions. The same happens to fish LGP2...
  54. Varzari A, Bruch K, Deyneko I, Chan A, Epplen J, Hoffjan S. Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients. J Neuroimmunol. 2014;277:140-4 pubmed publisher
    ..We investigated if polymorphisms in the IFIH1, RIG-I, LGP2 and VISA genes influence the risk for multiple sclerosis (MS) in a German case-control cohort comprising 716 ..
  55. Malur M, Gale M, Krug R. LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3. J Virol. 2012;86:10733-8 pubmed publisher
    b>LGP2, a member of the RIG-I-like receptor family, lacks the amino-terminal caspase activation recruitment domains (CARDs) required for initiating the activation of interferon regulatory factor 3 (IRF3) and interferon (IFN) transcription...
  56. Deddouche S, Goubau D, Rehwinkel J, Chakravarty P, Begum S, Maillard P, et al. Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells. elife. 2014;3:e01535 pubmed publisher
    The RIG-I-like receptors RIG-I, LGP2, and MDA5 initiate an antiviral response that includes production of type I interferons (IFNs). The nature of the RNAs that trigger MDA5 activation in infected cells remains unclear...
  57. Eslamloo K, Xue X, Hall J, Smith N, Caballero Solares A, Parrish C, et al. Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells. BMC Genomics. 2017;18:706 pubmed publisher
    ..Moreover, the qPCR revealed transcripts responding early to pIC (e.g. lgp2, map3k8, socs1, dusp5 and cflar) and time-responsive transcripts (e.g...
  58. Chopy D, Pothlichet J, Lafage M, Mégret F, Fiette L, Si Tahar M, et al. Ambivalent role of the innate immune response in rabies virus pathogenesis. J Virol. 2011;85:6657-68 pubmed publisher
    ..Here we show that expression of LGP2, a protein known as either a positive or negative regulator of the RIG-I-mediated innate immune response, is ..
  59. Hei L, Zhong J. Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses. Hepatology. 2017;65:1478-1491 pubmed publisher
    ..One of the RIG-I-like receptors, laboratory of genetics and physiology 2 (LGP2), was originally thought to be a negative feedback regulator in the RIG-I signaling pathway, but growing evidence ..
  60. Narita R, Takahasi K, Murakami E, Hirano E, Yamamoto S, Yoneyama M, et al. A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection. PLoS Pathog. 2014;10:e1004417 pubmed publisher
    ..Both proteins showed a specific association with LGP2, but not with RIG-I or MDA5...
  61. Cui Y, Li M, Walton K, Sun K, Hanover J, Furth P, et al. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Genomics. 2001;78:129-34 pubmed
    ..We identified six known genes and cloned two new genes, termed D11Lgp1 and D11Lgp2. Both genes are most highly expressed in normal mammary tissue and mammary tumors from several transgenic mouse ..
  62. Hu X, Chen S, Jia C, Xue S, Dou C, Dai Z, et al. Gene expression profile and long non-coding RNA analysis, using RNA-Seq, in chicken embryonic fibroblast cells infected by avian leukosis virus J. Arch Virol. 2018;163:639-647 pubmed publisher
    ..Notably, the induced expression of innate immunity genes, including B2M, DHX58, IFI27L2, IFIH1, IRF10, ISG12(2), MX, OAS*A, RSAD2, STAT1, TLR3, IL4I1, and IRF1 (FC > 2 and correlationÂ..
  63. Bogefors J, Kvarnhammar A, Latif L, Petterson T, Uddman R, Cardell L. Retinoic acid-inducible gene 1-like receptors in the upper respiratory tract. Am J Rhinol Allergy. 2011;25:e262-7 pubmed publisher
    ..Culture of FaDu with poly(I:C)/LyoVec resulted in IL-6 and IL-8 release. No alteration in RLR expression in tonsils was seen on infection...
  64. Liu J, Li J, Xiao J, Chen H, Lu L, Wang X, et al. The antiviral signaling mediated by black carp MDA5 is positively regulated by LGP2. Fish Shellfish Immunol. 2017;66:360-371 pubmed publisher
    Melanoma differentiation-associated gene 5 (MDA5) belongs to RIG-I like receptor (RLR) family, which detects cytosolic viral RNA component in immune response...
  65. Broquet A, Hirata Y, McAllister C, Kagnoff M. RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium. J Immunol. 2011;186:1618-26 pubmed publisher
  66. Koshiba T, Yasukawa K, Yanagi Y, Kawabata S. Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling. Sci Signal. 2011;4:ra7 pubmed publisher
    ..antiviral immunity depends on activation of the cytoplasmic retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling pathway and the participation of a mitochondrial outer membrane adaptor protein called MAVS (..
  67. Paria A, Deepika A, Sreedharan K, Makesh M, Chaudhari A, Purushothaman C, et al. Identification, ontogeny and expression analysis of a novel laboratory of genetics and physiology 2 (LGP2) transcript in Asian seabass, Lates calcarifer. Fish Shellfish Immunol. 2017;62:265-275 pubmed publisher
    b>LGP2 (laboratory of genetics and physiology 2) is an important member of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), which plays a significant role in antiviral innate immunity...
  68. Komuro A, Homma Y, Negoro T, Barber G, Horvath C. The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Biochem Biophys Res Commun. 2016;480:187-193 pubmed publisher
    b>LGP2 and MDA5 cooperate to detect viral RNA in the cytoplasm of Picornavirus-infected cells and activate innate immune responses...
  69. Rodriguez K, Horvath C. Paramyxovirus V protein interaction with the antiviral sensor LGP2 disrupts MDA5 signaling enhancement but is not relevant to LGP2-mediated RLR signaling inhibition. J Virol. 2014;88:8180-8 pubmed publisher
    ..I (RIG-I), melanoma differentiation-associated gene 5 (MDA5), and laboratory of genetics and physiology gene 2 (LGP2)...
  70. Fan Y, Mao R, Yu Y, Liu S, Shi Z, Cheng J, et al. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med. 2014;211:313-28 pubmed publisher
    ..Our studies identify a previously unrecognized role for USP21 in the negative regulation of antiviral response through deubiquitinating RIG-I. ..
  71. Miyashita M, Oshiumi H, Matsumoto M, Seya T. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. Mol Cell Biol. 2011;31:3802-19 pubmed publisher
    ..After viral infection, the DDX60 protein binds to endogenous RIG-I protein. The protein also binds to MDA5 and LGP2 but not to the downstream factors IPS-1 and I?B kinase ? (IKK-?)...
  72. Liu Y, Qu L, Liu Y, Roizman B, Zhou G. PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2. Proc Natl Acad Sci U S A. 2017;114:E6902-E6911 pubmed publisher
    ..A key function of PUM1 is that of a repressor of key innate immunity genes by repressing the expression of LGP2. Thus, between 12 and 48 hours after transfection of human cells with siPUM1 RNA there was an initial (phase 1) ..
  73. Corby M, Stoneman M, Biener G, Paprocki J, Kolli R, Raicu V, et al. Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells. J Biol Chem. 2017;292:11165-11177 pubmed publisher
    ..e. RIG-I, MDA5, or LGP2), expressed in the presence or absence of polyinosinic-polycytidylic acid (poly(I:C)), which elicits RLR ..