Gene Symbol: DHX30
Description: DExH-box helicase 30
Alias: DDX30, NEDMIAL, RETCOR, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 30, DEAH (Asp-Glu-Ala-His) box helicase 30, DEAH (Asp-Glu-Ala-His) box polypeptide 30, DEAH box protein 30, DEAH-box helicase 30, retina co-repressor
Species: human
Products:     DHX30

Top Publications

  1. Wang Y, Bogenhagen D. Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane. J Biol Chem. 2006;281:25791-802 pubmed
    ..mitochondrial proteins, multiple peptides were observed for one novel DNA metabolic protein, the DEAH-box helicase DHX30. Antibodies raised against a recombinant fragment of this protein confirmed the mitochondrial localization of a ..
  2. Zheng H, Tsukahara M, Liu E, Ye L, Xiong H, Noguchi S, et al. The novel helicase helG (DHX30) is expressed during gastrulation in mice and has a structure similar to a human DExH box helicase. Stem Cells Dev. 2015;24:372-83 pubmed publisher
    ..HelG encodes a protein of 137 kDa, which contains a DExH helicase motif that is now named DHX30. HelG is strongly expressed in neural cells (ie, in the headfold, neural plate, neural tube, and brain) and ..
  3. Farrar J, Schuback H, Ries R, Wai D, Hampton O, Treviño L, et al. Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse. Cancer Res. 2016;76:2197-205 pubmed publisher
    ..in (greater than or equal to) 2 patients] were identified for 10 genes (FLT3, NRAS, PTPN11, WT1, TET2, DHX15, DHX30, KIT, ETV6, KRAS), with variable persistence at relapse...
  4. Eldomery M, Coban Akdemir Z, Harel T, Rosenfeld J, Gambin T, Stray Pedersen A, et al. Lessons learned from additional research analyses of unsolved clinical exome cases. Genome Med. 2017;9:26 pubmed publisher
    ..MIPEP) and increased the number of novel genes, defined in this study as genes identified in more than one family (DHX30 and EBF3)...
  5. Höck J, Weinmann L, Ender C, Rüdel S, Kremmer E, Raabe M, et al. Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep. 2007;8:1052-60 pubmed
    ..Using reporter assays and knockdown experiments, we showed that the putative RNA-binding protein RBM4 is required for microRNA-guided gene regulation. ..
  6. Qin Q, Knapinska A, Dobri N, Madoux F, Chase P, Hodder P, et al. In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3. J Ocul Pharmacol Ther. 2013;29:298-309 pubmed publisher
    ..TR-FRET) assay assessing agonist-sensitive interaction between apo-NR2E3 and transcriptional corepressor RetCOR was used for characterization of the previously reported putative NR2E3 agonist, Compound 11a, and to conduct the ..
  7. Zhou Y, Ma J, Bushan Roy B, Wu J, Pan Q, Rong L, et al. The packaging of human immunodeficiency virus type 1 RNA is restricted by overexpression of an RNA helicase DHX30. Virology. 2008;372:97-106 pubmed
    ..Here, we provide evidence that overexpression of an RNA helicase named DHX30 enhances HIV-1 gene expression, but leads to the generation of viruses that package significantly low levels of ..
  8. Ye P, Liu S, Zhu Y, Chen G, Gao G. DEXH-Box protein DHX30 is required for optimal function of the zinc-finger antiviral protein. Protein Cell. 2010;1:956-64 pubmed publisher
    ..In this article, we provide evidence that a DEXH box RNA helicase, DHX30, is required for optimal antiviral activity of ZAP...
  9. Du Y, Gu S, Zhou J, Wang T, Cai H, Macinnes M, et al. The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest. Mol Cell Proteomics. 2006;5:1033-44 pubmed
    ..The dataset presented here demonstrates that sensitive profiling of the dynamics of functional cellular protein-protein interactions can successfully lead to the dissection of important metabolic or signaling pathways. ..

More Information


  1. Minczuk M, He J, Duch A, Ettema T, Chlebowski A, Dzionek K, et al. TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Res. 2011;39:4284-99 pubmed publisher
    ..RNA polymerase (POLRMT), pentatricopeptide repeat domain 3 protein (PTCD3), and a putative DEAD-box RNA helicase, DHX30. After RNase treatment only POLRMT remained associated with TEFM, and in human cultured cells TEFM formed foci ..
  2. Lessel D, Schob C, Küry S, Reijnders M, Harel T, Eldomery M, et al. De Novo Missense Mutations in DHX30 Impair Global Translation and Cause a Neurodevelopmental Disorder. Am J Hum Genet. 2017;101:716-724 pubmed publisher
    b>DHX30 is a member of the family of DExH-box helicases, which use ATP hydrolysis to unwind RNA secondary structures...
  3. Antonicka H, Shoubridge E. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Cell Rep. 2015;10:920-932 pubmed publisher
    ..Investigation of four uncharacterized putative RNA-binding proteins-two RNA helicases, DHX30 and DDX28, and two proteins of the Fas-activated serine-threonine kinase (FASTKD) family, FASTKD2 and FASTKD5-..