Gene Symbol: DHRS4L2
Description: dehydrogenase/reductase 4 like 2
Alias: SDR25C3, dehydrogenase/reductase SDR family member 4-like 2, NADP(H)-dependent retinol dehydrogenase/reductase short isoform-like protein, NADPH-dependent retinol dehydrogenase/reductase-like protein 2, dehydrogenase/reductase (SDR family) member 4 like 2, dehydrogenase/reductase (SDR family) member 4 like 2A3, short chain dehydrogenase/reductase family 25C member 3
Song X, Liang B, Liu G, Li R, Xie J, Du K, et al
. Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. Int J Cancer. 2007;120:1618-26 pubmed
..The results presented here provide evidence that metabolic disturbances of retinal and retinoic acid, due to abnormal splicing and functional disorder of NRDR, may be involved in cervical tumorigenesis. ..
Zhang Q, Li Y, Liu G, Xu X, Song X, Liang B, et al
. Alternative transcription initiation and splicing variants of the DHRS4 gene cluster. Biosci Rep. 2009;29:47-56 pubmed publisher
..short-chain dehydrogenase/reductase superfamily member 4) gene cluster, consisting of DHRS4 and its copy gene DHRS4L2, is localized on 14q11.2...
Yang Y, Su Z, Song X, Liang B, Zeng F, Chang X, et al
. Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster. Sci Rep. 2016;6:20961 pubmed publisher
The human DHRS4 gene cluster consists of DHRS4 and two immediately downstream homologous genes, DHRS4L2 and DHRS4L1, generated by evolutionarily gene-duplication events...
Fransen M, Van Veldhoven P, Subramani S. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. Biochem J. 1999;340 ( Pt 2):561-8 pubmed
Du J, Huang D, Liu G, WANG G, Xu X, Wang B, et al
. CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics. Yi Chuan Xue Bao. 2004;31:661-7 pubmed
..The open reading frames of the NRDRiso cDNA predict a single polypeptide of 174 amino acids with the calculated minimum molecular mass of 18.6 kDa. ..
Hiller M, Huse K, Platzer M, Backofen R. Non-EST based prediction of exon skipping and intron retention events using Pfam information. Nucleic Acids Res. 2005;33:5611-21 pubmed
..As Pfam domains are annotated in many other species, our strategy to predict exon skipping and intron retention events might be important for species with a lower number of ESTs. ..
Su Z, Zhang Q, Liu G, Song X, Li Q, Wang R, et al
. Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation. BMC Mol Biol. 2010;11:43 pubmed publisher
The human DHRS4 gene cluster consists of three genes, DHRS4, DHRS4L2 and DHRS4L1. Among them, DHRS4 encodes NADP(H)-dependent retinol dehydrogenase/reductase...
Su Z, Liu G, Song X, Liang B, Chang X, Huang D. CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription. Genet Mol Res. 2016;15: pubmed publisher
..gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in chimpanzees and humans, respectively...