Gene Symbol: DHRS4L1
Description: dehydrogenase/reductase 4 like 1
Alias: SDR25C4, short chain dehydrogenase/reductase family 25C member 4
Yang Y, Su Z, Song X, Liang B, Zeng F, Chang X, et al
. Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster. Sci Rep. 2016;6:20961 pubmed publisher
The human DHRS4 gene cluster consists of DHRS4 and two immediately downstream homologous genes, DHRS4L2 and DHRS4L1, generated by evolutionarily gene-duplication events...
Su Z, Liu G, Song X, Liang B, Chang X, Huang D. CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription. Genet Mol Res. 2016;15: pubmed publisher
..while only one DHRS4 gene is expressed in the mouse genome, the gene cluster consists of two (DHRS4 and DHRS4L1) and three (DHRS4, DHRS4L2, and DHRS4L1) copies in chimpanzees and humans, respectively...
Fransen M, Van Veldhoven P, Subramani S. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. Biochem J. 1999;340 ( Pt 2):561-8 pubmed
Li Q, Su Z, Xu X, Liu G, Song X, Wang R, et al
. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans. Proc Natl Acad Sci U S A. 2012;109:14110-5 pubmed publisher
..a metabolic enzyme and forms a gene cluster with its two immediately downstream homologous genes, DHRS4L2 and DHRS4L1, generated by gene duplication...
Su Z, Zhang Q, Liu G, Song X, Li Q, Wang R, et al
. Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation. BMC Mol Biol. 2010;11:43 pubmed publisher
The human DHRS4 gene cluster consists of three genes, DHRS4, DHRS4L2 and DHRS4L1. Among them, DHRS4 encodes NADP(H)-dependent retinol dehydrogenase/reductase...