DHH

Summary

Gene Symbol: DHH
Description: desert hedgehog
Alias: GDXYM, HHG-3, SRXY7, desert hedgehog protein
Species: human
Products:     DHH

Top Publications

  1. Chuang P, McMahon A. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature. 1999;397:617-21 pubmed
    ..Our findings support a model in which Hip attenuates Hedgehog signalling as a result of binding to Hedgehog proteins: a negative regulatory feedback loop established in this way could thus modulate the responses to any Hedgehog signal. ..
  2. Umehara F, Tate G, Itoh K, Osame M. Minifascicular neuropathy: a new concept of the human disease caused by desert hedgehog gene mutation. Cell Mol Biol (Noisy-le-grand). 2002;48:187-9 pubmed
    ..We found in the patient, a homozygous missense mutation at the initiating codon in exon 1 of the desert hedgehog (DHH) gene, which predicts a failure of translation of the gene...
  3. Wu X, Liu J, Duan Y, Gao S, Lu Y, Li X, et al. A Short-Term Exposure to Tributyltin Blocks Leydig Cell Regeneration in the Adult Rat Testis. Front Pharmacol. 2017;8:704 pubmed publisher
    ..of Leydig (Lhcgr, Cyp11a1, Hsd3b1, Cyp17a1, and Hsd17b3) and Sertoli cells (Fshr, Dhh, and Sox9) were significantly down-regulated in the TBT-treated testes when compared to the control...
  4. Qin X, Dong W, Wang W, Dong Z, Xiao Y, Lu W, et al. [Analysis of clinical features and related genes variation in five patients with 46, XX male syndrome]. Zhonghua Er Ke Za Zhi. 2016;54:840-843 pubmed publisher
    ..The copy number variations of SOX9 gene was found in one case, the loss of heterozygosity area in DHH gene of one case...
  5. Chen S, Liu Y. Testis Cord Maintenance in Mouse Embryos: Genes and Signaling. Biol Reprod. 2016;94:42 pubmed publisher
    ..testis cord integrity by a series of Sertoli cell transcription factors, including the WT1-SOX8/SOX9-beta-CATENIN-DHH network, GPR56, STIM1, and NR0B1 (also known as DAX1)...
  6. Kussmann M, Karer M, Obermueller M, Schmidt K, Barousch W, Moser D, et al. Emergence of a dalbavancin induced glycopeptide/lipoglycopeptide non-susceptible Staphylococcus aureus during treatment of a cardiac device-related endocarditis. Emerg Microbes Infect. 2018;7:202 pubmed publisher
    ..Therefore, the mutations in pbp2 and the DHH domain of GdpP were identified as the most probable candidates due to their implication in the biosynthesis and ..
  7. Commichau F, Heidemann J, Ficner R, Stülke J. Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria. J Bacteriol. 2019;201: pubmed publisher
    ..The phosphodiesterases have a catalytic core that consists either of a DHH/DHHA1 or of an HD domain...
  8. Makala H, Pothana L, Sonam S, Malla A, Goel S. Regeneration of Leydig cells in ectopically autografted adult mouse testes. Reproduction. 2015;149:259-68 pubmed publisher
    ..Elevated expression of PDGFRA, LIF, DHH and NEFH in autografts indicated de novo regeneration of LC populations...
  9. Janakiraman H, Nobukiyo A, Inoue H, Kanno M. Mel-18 controls the enrichment of tumor-initiating cells in SP fraction in mouse breast cancer. Hiroshima J Med Sci. 2011;60:25-35 pubmed
    ..Stem cell pathway focused gene expression profiling of V3 and S2 cells revealed that the genes Abcg2, Aldh1a1 and Dhh were highly down-regulated in V3 compared to S2...

More Information

Publications114 found, 100 shown here

  1. Yang Z, Peng Y, Gopalan A, Gao D, Chen Y, Joyner A. Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer. Dis Model Mech. 2017;10:39-52 pubmed publisher
    ..in SMCs and fibroblasts near tumor cells in all models, and epithelial Shh expression is decreased whereas Ihh and Dhh are increased...
  2. Remédio L, Carvalho T, Caiado F, Bastos Carvalho A, Martins D, Duarte A, et al. Context- and cell-dependent effects of Delta-like 4 targeting in the bone marrow microenvironment. PLoS ONE. 2012;7:e52450 pubmed publisher
    ..the expression of angiocrine genes upon Dll4 treatment in vivo, and demonstrate that IGFbp2, IGFbp3, Angpt2, Dll4, DHH and VEGF-A are upregulated, while FGF1 and CSF2 are reduced...
  3. Fan W, Wang B, He S, Zhang T, Yin C, Chen Y, et al. A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis. PLoS ONE. 2016;11:e0168484 pubmed publisher
    ..sequencing using the DNA samples from the proband and the parents, and no mutations were identified especially in DHH, NR0B1, NR5A1, SOX9 and MAP3K1, indicating the de novo mutation in SRY is the single defect responsible for the ..
  4. Shiozaki A, Kudou M, Ichikawa D, Shimizu H, Arita T, Kosuga T, et al. Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma. Oncotarget. 2017;8:17921-17935 pubmed publisher
    ..The results of the microarray analysis revealed that MAPK and Hedgehog signaling pathway-related genes, such as DHH, and GLI1, were down-regulated in AE1-depleted KYSE150 cells...
  5. Rudigier L, Dame C, Scholz H, Kirschner K. Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation. PLoS ONE. 2017;12:e0176296 pubmed publisher
    ..of the hedgehog signaling pathway in XY gonads, whereas Gata4 vivo-morpholino treatment increased transcripts of Dhh and Ptch1 in embryonic testes...
  6. Wu X, Guo X, Wang H, Zhou S, Li L, Chen X, et al. A brief exposure to cadmium impairs Leydig cell regeneration in the adult rat testis. Sci Rep. 2017;7:6337 pubmed publisher
    ..levels of Leydig (Lhcgr, Scarb1, Star, Cyp11a1, Hsd3b1, Cyp17a1, Hsd17b3, and Hsd11b1), non-Leydig (Fshr and Dhh), and gonadotroph (Lhb) cells were also significantly lower in cadmium-treated animals...
  7. Wang B, Qi T, Chen S, Ye L, Huang Z, Li H. RFX1 maintains testis cord integrity by regulating the expression of Itga6 in male mouse embryos. Mol Reprod Dev. 2016;83:606-14 pubmed publisher
    ..At least five genes (Wt1, Dhh, Sox8/Sox9, and Dax1) appear to be required for the maintenance of testis cord integrity in mice...
  8. Nelersa C, Schmier B, Malhotra A. Purification and crystallization of Bacillus subtilis NrnA, a novel enzyme involved in nanoRNA degradation. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:1235-8 pubmed publisher
    ..However, many bacteria lack Orn homologs, and an unrelated DHH-family phosphoesterase, NrnA, has recently been identified as one of the enzymes responsible for nanoRNA ..
  9. De Sousa S, Kassahn K, McIntyre L, Chong C, Scott H, Torpy D. Case report of whole genome sequencing in the XY female: identification of a novel SRY mutation and revision of a misdiagnosis of androgen insensitivity syndrome. BMC Endocr Disord. 2016;16:58 pubmed
    ..The clinical phenotype suggested several susceptibility genes including SRY, DHH, NR5A1, NR0B1, AR, AMH, and AMHR2. To study candidate genes simultaneously, we performed whole genome sequencing...
  10. Chen X, Dong Y, Tian E, Xie L, Wang G, Li X, et al. 4-Bromodiphenyl ether delays pubertal Leydig cell development in rats. Chemosphere. 2018;211:986-997 pubmed publisher
    ..E.). BDE-3 decreased Leydig cell size and cytoplasmic size at a dose of 200 mg/kg, decreased Lhcgr, Star, Dhh, and Sox9 mRNA levels at ≥ 100 mg/kg and Scarb1, Cyp11a1, Hsd17b3, and Fshr at 200 mg/kg...
  11. Wang X, Shen Y, Cheng Q, Fu C, Zhou Z, Hirose S, et al. Apontic directly activates hedgehog and cyclin E for proper organ growth and patterning. Sci Rep. 2017;7:12470 pubmed publisher
    ..silencer-binding protein (FSBP), a mammalian homolog of Apt, also positively regulates Sonic hh (Shh), Desert hh (Dhh), Cyclin E1 (CCNE1) and Cyclin E2 (CCNE2) in cultured human cells, suggesting evolutionary conservation of the ..
  12. Kang X, Yang M, Shi Y, Xie M, Zhu M, Zheng X, et al. Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors. Cell Commun Signal. 2018;16:42 pubmed publisher
    ..These findings supported the potential role of IL-15 as a modulator on fate of FAPs in injured muscle and as a novel therapy for chronic muscle injury. ..
  13. Lin Y, Roffler S, Yan Y, Yang R. Disruption of Scube2 Impairs Endochondral Bone Formation. J Bone Miner Res. 2015;30:1255-67 pubmed publisher
    ..However, whether SCUBE2 can regulate the signaling activity of two other hedgehog ligands (Ihh and Dhh), and the developmental relevance of the SCUBE2-induced hedgehog signaling in mammals remain poorly understood...
  14. Lan X, Wen H, Cheng K, Plagov A, Marashi Shoshtari S, Malhotra A, et al. Hedgehog pathway plays a vital role in HIV-induced epithelial-mesenchymal transition of podocyte. Exp Cell Res. 2017;352:193-201 pubmed publisher
    ..showed that renal tissue expression of hedgehog pathway related molecules, including hedgehog homologous (Shh, Ihh, Dhh), PTCH, and Gli1, were increased in HIVAN (Tg26) mice; while immunofluorescent staining displayed localization PTCH ..
  15. Oyama T, Ishino S, Shirai T, Yamagami T, Nagata M, Ogino H, et al. Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication. Nucleic Acids Res. 2016;44:9505-9517 pubmed
    ..GAN possesses the conserved DHH and DHH1 domains responsible for the exonuclease activity, and an inserted CID (CMG interacting domain)-like domain ..
  16. DEOCAMPO J, Smith G, Kronenberger W, Pisoni D, Conway C. The Role of Statistical Learning in Understanding and Treating Spoken Language Outcomes in Deaf Children With Cochlear Implants. Lang Speech Hear Serv Sch. 2018;49:723-739 pubmed publisher
    ..working memory training, statistical learning training, deaf, deafness, hearing impairment, hearing impaired, DHH, hard of hearing, cochlear implant(s), hearing aid(s), and auditory deprivation...
  17. Liu J, Wang Y, Fang Y, Ni C, Ma L, Zheng W, et al. Gestational exposure to ziram disrupts rat fetal Leydig cell development. Chemosphere. 2018;203:393-401 pubmed publisher
    ..the expression of Leydig (Nr5a1, Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, and Insl3) and Sertoli cell (Fshr, Hsd17b3, Dhh, Amh, and Sox9) genes and proteins was downregulated by ziram at 8?mg/kg...
  18. Costain G, Shugar A, Krishnan P, Mahmutoglu S, Laughlin S, Kannu P. Homozygous mutation in PRUNE1 in an Oji-Cree male with a complex neurological phenotype. Am J Med Genet A. 2017;173:740-743 pubmed publisher
    The PRUNE1 gene encodes a member of the phosphoesterases (DHH) protein superfamily that is highly expressed in the human fetal brain and involved in the regulation of cell migration...
  19. Michael R, Cinamon R, Most T. Career-related parental support of adolescents with hearing loss: relationships with parents' expectations and occupational status. Am Ann Deaf. 2015;160:60-72 pubmed publisher
    ..regarding persons with hearing loss to career-related support they provide their deaf and hard of hearing (dhh) adolescent children...
  20. Simon A, Sannino V, Costanzo V, Pellegrini L. Structure of human Cdc45 and implications for CMG helicase function. Nat Commun. 2016;7:11638 pubmed publisher
    ..These include a long-range interaction between N- and C-terminal DHH domains, blocking access to the DNA-binding groove of its RecJ-like fold, and a helical insertion in its N-terminal ..
  21. Zollo M, Ahmed M, Ferrucci V, Salpietro V, Asadzadeh F, Carotenuto M, et al. PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment. Brain. 2017;140:940-952 pubmed publisher
    PRUNE is a member of the DHH (Asp-His-His) phosphoesterase protein superfamily of molecules important for cell motility, and implicated in cancer progression...
  22. Ding J, Delpire E. Deletion of KCC3 in parvalbumin neurons leads to locomotor deficit in a conditional mouse model of peripheral neuropathy associated with agenesis of the corpus callosum. Behav Brain Res. 2014;274:128-36 pubmed publisher
    ..Together, these results establish that the parvalbumin-positive neuronal population is an important player in the pathogenic development of ACCPN. ..
  23. Huynh T, Woodward J. Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm. Curr Opin Microbiol. 2016;30:22-29 pubmed publisher
    ..comprises GdpP and DhhP homologs, which degrade c-di-AMP into the linear molecule 5'-pApA or AMP by the DHH-DHHA1 domain. The other major class comprises PgpH homologs, which degrade c-di-AMP by the HD domain...
  24. Kurniawan F, Shi K, Kurahashi K, Bielinsky A, Aihara H. Crystal Structure of Entamoeba histolytica Cdc45 Suggests a Conformational Switch that May Regulate DNA Replication. iScience. 2018;3:102-109 pubmed publisher
    ..conformation, featuring the overall disk-like monomer shape and intimate contacts between the N- and C-terminal DHH domains. However, the E...
  25. Perepelov A, Guo X, Filatov A, Shashkov A, Senchenkova S, Li B. Structure elucidation and gene cluster annotation of the O-antigen of Vibrio cholerae O100 containing two rarely occurred amino sugar derivatives. Carbohydr Res. 2019;472:98-102 pubmed publisher
    ..The following structure of the O-polysaccharide was established: →3)-β-d-QuipNAc4N(dHh)-(1 → 3)-α-d-Fucp4N(RHb)-(1 → 3)-α-l-FucpNAc-(1→ where Hb and dHh indicate 3-hydroxybutanoyl and 3,..
  26. Bruce S, Borders C. Communication and Language in Learners Who Are Deaf and Hard of Hearing With Disabilities: Theories, Research, and Practice. Am Ann Deaf. 2015;160:368-84 pubmed publisher
    ..intervention research in three areas related to deafness with disability (DWD): D/deaf and hard of hearing (DHH) with (a) intellectual disability, (b) autism spectrum disorders, (c) deafblindness...
  27. Williams L, Porter J, Scott J, Smith T, Vogt T. Investigating the Risk of Date Rape by Auditory Status. Violence Vict. 2017;32:1044-1062 pubmed publisher
    ..Findings indicated that Deaf and hard of hearing (DHH) students were more likely to experience negative sexual experiences than hearing students...
  28. Li X, Liu J, Wu S, Zheng W, Li H, Bao S, et al. In utero single low-dose exposure of cadmium induces rat fetal Leydig cell dysfunction. Chemosphere. 2018;194:57-66 pubmed publisher
    ..expression levels of Leydig (LHCGR, SCARB1, STAR, CYP11A1, HSD3B1, and CYP17A1), and Sertoli cells (HSD17B3, DHH, and FSHR)...
  29. Cheng S, Zhang L, Hu X. Thinking Styles and University Self-Efficacy Among Deaf, Hard-of-Hearing, and Hearing Students. J Deaf Stud Deaf Educ. 2016;21:44-53 pubmed publisher
    ..the Thinking Styles Inventory-Revised II and the University Self-Efficacy Scale to 366 deaf or hard-of-hearing (DHH) and 467 hearing university students in mainland China...
  30. Wang Y, Williams C. Are we hammering square pegs into round holes? An investigation of the meta-analyses of reading research with students who are d/Deaf or hard of hearing and students who are hearing. Am Ann Deaf. 2014;159:323-45 pubmed
    ..special education hearing students (including English Language Learners), and d/Deaf or hard of hearing (d/Dhh) students. Generally, the meta-analysis yielded findings similar to and corroborative of the NRP's...
  31. Roessler E, El Jaick K, Dubourg C, Vélez J, Solomon B, Pineda Alvarez D, et al. The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis. Hum Mutat. 2009;30:E921-35 pubmed publisher
    ..64 novel mutations) and compare these to over a dozen mutations in disease-related Hedgehog family members IHH and DHH. This combined structural analysis suggests that dysfunction of Hedgehog signaling in human forebrain development ..
  32. Wendel E, Cawthon S, Ge J, Beretvas S. Alignment of single-case design (SCD) research with individuals who are deaf or hard of hearing with the what Works Clearinghouse standards for SCD research. J Deaf Stud Deaf Educ. 2015;20:103-14 pubmed publisher
    ..SCD) studies that assess the impact of interventions on outcomes for individuals who are deaf or hard-of-hearing (DHH)...
  33. Romling U, Liang Z, Dow J. Progress in Understanding the Molecular Basis Underlying Functional Diversification of Cyclic Dinucleotide Turnover Proteins. J Bacteriol. 2017;199: pubmed publisher
    ..we highlight that superfamily diversification is not restricted to cyclic di-GMP signaling domains, as particular DHH/DHHA1 domain and HD domain proteins have been shown to act as cyclic di-AMP phosphodiesterases...
  34. Dye M, Emmorey K. Special Section on Multimodal Multilingual Development of DHH Learners. J Deaf Stud Deaf Educ. 2017;22:402-403 pubmed publisher
    ..This issue begins the inclusion of a series of articles on multimodal, multilingual communication development. This special section is intended to run for two or three issues, with two or three contributions in each issue. ..
  35. La Sala G, Marazziti D, Di Pietro C, Golini E, Matteoni R, Tocchini Valentini G. Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. FASEB J. 2015;29:2059-69 pubmed publisher
    ..It also affects the prepubertal testis expression of desert hedgehog (Dhh) mitogenic cascade components (Dhh, 1.3-fold increase in Gpr37(-/-) P10 and P21 pups; Gli2, 1.4-fold and 1...
  36. Wellbrock J, Latuske E, Köhler J, Wagner K, Stamm H, Vettorazzi E, et al. Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects. Clin Cancer Res. 2015;21:2388-98 pubmed publisher
    ..AML cells did not express Hedgehog ligands by qPCR, AML patients had significantly increased Desert Hedgehog (DHH) plasma levels compared with healthy subjects (P = 0...
  37. Cannon J, Guardino C, Antia S, Luckner J. Single-Case Design Research: Building the Evidence-Base in the Field of Education of Deaf and Hard of Hearing Students. Am Ann Deaf. 2016;160:440-52 pubmed publisher
    The field of education of deaf and hard of hearing (DHH) students has a paucity of evidence-based practices (EBPs) to guide instruction...
  38. Chauhan V, Jyotsna V, Jain V, Khadgawat R, Dada R. Novel Heterozygous Genetic Variants in Patients with 46,XY Gonadal Dysgenesis. Horm Metab Res. 2017;49:36-42 pubmed publisher
    ..Direct sequencing of SRY, NR5A1, SOX9, DAX1, DHH, DMRT1 genes was carried out for molecular analysis...
  39. Derouiche L, Vercammen P, Bouhadad R, Fernandes C. Genetic evidence supporting the taxonomic separation of the Arabian and Northwest African subspecies of the desert hedgehog (Paraechinus aethiopicus). Gene. 2017;620:54-65 pubmed publisher
    ..This study, as a test of the genetic distinctiveness of dorsalis and deserti, suggests that they represent evolutionarily significant units and flags them for future phylogeographic and taxonomic investigations. ..
  40. Meinzen Derr J, Wiley S, Phillips J, Altaye M, Choo D. The utility of early developmental assessments on understanding later nonverbal IQ in children who are deaf or hard of hearing. Int J Pediatr Otorhinolaryngol. 2017;92:136-142 pubmed publisher
    In children who are deaf or hard of hearing (DHH), it is helpful to have meaningful early measures of development in order to provide effective interventions and offer benchmarks that help recognize varied developmental trajectories...
  41. Keng V, Watson A, Rahrmann E, Li H, Tschida B, Moriarity B, et al. Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. Sarcoma. 2012;2012:620834 pubmed publisher
    ..under the control of the 2',3'-cyclic nucleotide 3'phosphodiesterase (Cnp) promoter and a desert hedgehog (Dhh) regulatory element driving Cre recombinase transgenic mice (Dhh-Cre)...
  42. Mizukoshi K, Koyama N, Hayashi T, Zheng L, Matsuura S, Kashimata M. Shh/Ptch and EGF/ErbB cooperatively regulate branching morphogenesis of fetal mouse submandibular glands. Dev Biol. 2016;412:278-87 pubmed publisher
    ..These results show that Shh stimulates BrM of fetal mouse SMG, at least in part, through activation of the EGF/ErbB/ERK1/2 signaling system. ..
  43. Riaz S, Khan J, Shah S, Wang F, Ye L, Jiang W, et al. Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer. Cell Commun Signal. 2018;16:3 pubmed publisher
    ..Based on differential expression, panel of 6 key regulators of the pathway (SHH, DHH, IHH, PTCH1, SMO and GLI1) in microarray datasets were identified...
  44. Moreland C, Atcherson S, Zazove P, MCKEE M. Hearing Loss: Issues in the Deaf and Hard of Hearing Communities. FP Essent. 2015;434:29-40 pubmed
    ..More than 90% of deaf and hard of hearing (DHH) children are born to hearing parents who may lack the knowledge or experience to effectively care for a child with ..
  45. Baker S, Scott J. Sociocultural and Academic Considerations for School-Age d/Deaf and Hard of Hearing Multilingual Learners: A Case Study of a Deaf Latina. Am Ann Deaf. 2016;161:43-55 pubmed publisher
    ..However, a growing population of d/Dhh children come from households where languages other than English (e.g., Spanish, Chinese, Vietnamese) are used...
  46. Marshall M, Carrano A, Dannels W. Adapting Experiential Learning to Develop Problem-Solving Skills in Deaf and Hard-of-Hearing Engineering Students. J Deaf Stud Deaf Educ. 2016;21:403-15 pubmed publisher
    Individuals who are deaf and hard-of-hearing (DHH) are underrepresented in science, technology, engineering, and mathematics (STEM) professions, and this may be due in part to their level of preparation in the development and retention ..
  47. Guan C, Wang Y. The Effect of Handwriting Training on Language Learning Among Deaf Children and Their Matched Hearing Peers in China. Am Ann Deaf. 2017;162:265-276 pubmed publisher
    Comparing deaf and hard of hearing (DHH) children with their hearing peers in learning Chinese, the study tested the lexical quality hypothesis (Perfetti, 1992, 2007), which asserts the importance of building orthographic, phonological, ..
  48. Pan J, Cheng X, Sharp M, Ho C, Khadka N, Katsaras J. Structural and mechanical properties of cardiolipin lipid bilayers determined using neutron spin echo, small angle neutron and X-ray scattering, and molecular dynamics simulations. Soft Matter. 2015;11:130-8 pubmed publisher
    ..Of note, the distance between electron density maxima DHH (39.4 Ã…) and the hydrocarbon chain thickness 2DC (29...
  49. Cannon J, Hubley A, Millhoff C, Mazlouman S. Comprehension of Written Grammar Test: Reliability and Known-Groups Validity Study With Hearing and Deaf and Hard-of-Hearing Students. J Deaf Stud Deaf Educ. 2016;21:54-63 pubmed publisher
    ..test of 26 grammatical structures of English print for use with children who are deaf and hard of hearing (DHH). Reliability and validity data were collected for 98 participants (49 DHH and 49 hearing) in Grades 2-6...
  50. Michael R, Attias J. Cognitive autonomy among adolescents with and without hearing loss: Associations with perceived social support. J Adolesc. 2016;48:36-44 pubmed publisher
    ..Participants were 177 students: 55 were deaf and hard of hearing (dhh) and 122 were hearing...
  51. Cheng S, Hu X, Sin K. Thinking styles of university deaf or hard of hearing students and hearing students. Res Dev Disabil. 2016;55:377-87 pubmed publisher
    Although their university enrollment has increased dramatically over the past two decades, deaf or hard of hearing (DHH) students face great challenges and a tremendous environmental adjustment when entering a mainstream university...
  52. Hintermair M, Sarimski K, Lang M. Preliminary Evidence Assessing Social-Emotional Competences in Deaf and Hard of Hearing Infants and Toddlers Using a New Parent Questionnaire. J Deaf Stud Deaf Educ. 2017;22:143-154 pubmed publisher
    Social-emotional competences are an important developmental domain for deaf and hard of hearing (DHH) children and early diagnosis of problems is needed to ensure that DHH children receive appropriate support in this domain...
  53. Laughlin M, Yang H, Tharp D, Rector R, Padilla J, Bowles D. Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees. Microcirculation. 2017;24: pubmed publisher
    ..EXT increased expression of some genes (Shc1, desert hedgehog protein (Dhh), adenylate cyclase 4 (Adcy4), G protein-binding protein, alpha (Gnat1), and Bcl2l1) in all ..
  54. Luft P. Transition Services for DHH Adolescents and Young Adults With Disabilities: Challenges and Theoretical Frameworks. Am Ann Deaf. 2015;160:395-414 pubmed publisher
    Deaf and hard of hearing (DHH) adolescents and young adults with disabilities (DWD) are a highly diverse group who may also demonstrate a range of functional limitations...
  55. Li X, Wang Z, Jiang Z, Guo J, Zhang Y, Li C, et al. Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes. Proc Natl Acad Sci U S A. 2016;113:2666-71 pubmed publisher
    ..The proliferation of the stem Leydig cells was stimulated by paracrine factors including Desert hedgehog (DHH), basic fibroblast growth factor (FGF2), platelet-derived growth factor (PDGF), and activin...
  56. Cai K, Hua G, Ahmad S, Liang A, Han L, Wu C, et al. Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice. PLoS ONE. 2011;6:e25585 pubmed publisher
    ..Inha silencing also suppressed Pdgfa, Igf1, and Kitl mRNA levels and up-regulated Tgfbrs, Inhba, Inhbb, Cyp11a1, Dhh, and Tjp1 mRNA levels (as indicated by real-time polymerase chain reaction [PCR] analysis)...
  57. Punch R. Employment and Adults Who Are Deaf or Hard of Hearing: Current Status and Experiences of Barriers, Accommodations, and Stress in the Workplace. Am Ann Deaf. 2016;161:384-97 pubmed publisher
    ..period 2004-2016, the author presents a current picture of the situation of people who are deaf or hard of hearing (DHH) relative to employment and careers-particularly the barriers, facilitators, and stress levels experienced by ..
  58. Trussell J, Easterbrooks S. Effects of Morphographic Instruction on the Morphographic Analysis Skills of Deaf and Hard-of-Hearing Students. J Deaf Stud Deaf Educ. 2015;20:229-41 pubmed publisher
    Deaf and hard-of-hearing (DHH) students have delayed morphographic knowledge that negatively affects their morphographic analysis and decoding abilities...
  59. Holmer E, Heimann M, Rudner M. Evidence of an association between sign language phonological awareness and word reading in deaf and hard-of-hearing children. Res Dev Disabil. 2016;48:145-59 pubmed publisher
    ..Here, we asked whether Swedish deaf and hard-of-hearing (DHH) children who are more aware of the phonology of Swedish Sign Language, a language with no orthography, are better ..
  60. He Q, Wang F, Liu S, Zhu D, Cong H, Gao F, et al. Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase. J Biol Chem. 2016;291:3668-81 pubmed publisher
    ..Rv2837c from M. tuberculosis is a soluble, stand-alone DHH-DHHA1 domain phosphodiesterase that down-regulates c-di-AMP through catalytic degradation and plays an important ..
  61. Nagle K, Newman L, Shaver D, Marschark M. College and Career Readiness: Course Taking Of Deaf and Hard of Hearing Secondary School Students. Am Ann Deaf. 2016;160:467-82 pubmed publisher
    Research shows that deaf and hard of hearing (DHH) students frequently enter college and the workplace relatively unprepared for success in math, science, and reading...
  62. van Berkel van Hoof L, Hermans D, Knoors H, Verhoeven L. Benefits of augmentative signs in word learning: Evidence from children who are deaf/hard of hearing and children with specific language impairment. Res Dev Disabil. 2016;59:338-350 pubmed publisher
    ..word learning in children with vocabulary difficulties, for example, children who are Deaf/Hard of Hearing (DHH) and children with Specific Language Impairment (SLI)...
  63. Bowman L, Zeden M, Schuster C, Kaever V, GRUNDLING A. New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance in Staphylococcus aureus. J Biol Chem. 2016;291:26970-26986 pubmed publisher
    ..Here we show that in addition to the membrane-bound Asp-His-His and Asp-His-His-associated (DHH/DHHA1) domain-containing phosphodiesterase (PDE) GdpP, S. aureus produces a second cytoplasmic DHH/DHHA1 PDE Pde2...
  64. Crowe K, McLeod S, McKinnon D, Ching T. Attitudes toward the capabilities of deaf and hard of hearing adults: insights from the parents of deaf and hard of hearing children. Am Ann Deaf. 2015;160:24-35 pubmed publisher
    Children who are d/Deaf and hard of hearing (DHH) grow up in environments influenced by their parents' attitudes, which may facilitate or impede these children's development and participation (World Health Organization, 2007)...
  65. Easterbrooks S, Lederberg A, Antia S, Schick B, Kushalnagar P, Webb M, et al. Reading among diverse DHH learners: what, how, and for whom?. Am Ann Deaf. 2015;159:419-32 pubmed
    Students whO are deaf and hard of hearing (DHH) face challenges in learning to read...
  66. Kazmers N, McKenzie J, Shen T, Long F, Silva M. Hedgehog signaling mediates woven bone formation and vascularization during stress fracture healing. Bone. 2015;81:524-32 pubmed publisher
    ..GDC-0449 did not affect Hh ligand expression (Shh, Ihh, Dhh) at 1 day, but decreased Shh expression by 37% at 3 days...
  67. Azzi S, Treps L, Leclair H, Ngo H, Harford Wright E, Gavard J. Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma. Front Pharmacol. 2015;6:281 pubmed publisher
    ..Interestingly, BTICs produce desert hedgehog (DHH) ligand, enabling a paracrine DHH/Ptch2 signaling cascade that conveys elevated permeability and angiogenesis...
  68. Wolbers K, Dostal H, Graham S, Cihak D, Kilpatrick J, Saulsburry R. The Writing Performance of Elementary Students Receiving Strategic and Interactive Writing Instruction. J Deaf Stud Deaf Educ. 2015;20:385-98 pubmed publisher
    ..Writing Instruction (SIWI) has led to improved writing and language outcomes among deaf and hard of hearing (DHH) middle grades students...
  69. Gilliver M, Cupples L, Ching T, Leigh G, Gunnourie M. Developing Sound Skills for Reading: Teaching Phonological Awareness to Preschoolers With Hearing Loss. J Deaf Stud Deaf Educ. 2016;21:268-79 pubmed publisher
    This study evaluated the effectiveness of intervention for developing deaf and hard-of-hearing (DHH) preschoolers' phonological awareness (PA) skills...
  70. Schultzel M, SCHEIDT K, Klein C, Narvy S, Lee B, Itamura J. Hemiarthroplasty for the treatment of distal humeral fractures: midterm clinical results. J Shoulder Elbow Surg. 2017;26:389-393 pubmed publisher
    ..Distal humeral hemiarthroplasty (DHH) offers an alternative with multiple advantages...
  71. Guardino C, Cannon J. Deafness and Diversity: Reflections and Directions. Am Ann Deaf. 2016;161:104-12 pubmed publisher
    ..diversity (DAD), the editors provide reflections and guidance to the field regarding d/Deaf and hard of hearing (d/Dhh) children with a disability (DWD; e.g...
  72. Cannon J, Luckner J. Increasing Cultural And Linguistic Diversity In Deaf Education Teacher Preparation Programs. Am Ann Deaf. 2016;161:89-103 pubmed publisher
    As the field of education of the d/Deaf and hard of hearing (d/Dhh) continues to diversify, postsecondary institutions must pay close attention not only to the changing needs of d/Dhh students but to the practitioners they are preparing ..
  73. Antia S, Rivera M. Instruction and Service Time Decisions: Itinerant Services to Deaf and Hard-of-Hearing Students. J Deaf Stud Deaf Educ. 2016;21:293-302 pubmed publisher
    ..was to (a) describe the specific kinds of services provided by itinerant teachers to deaf and hard-of-hearing (DHH) students in general education settings, (b) examine the relationship between student academic performance and ..
  74. Chen H, Wang Y, Ge R, Zirkin B. Leydig cell stem cells: Identification, proliferation and differentiation. Mol Cell Endocrinol. 2017;445:65-73 pubmed publisher
    ..We have shown that the proliferation of the SLCs is stimulated by DHH, FGF2, PDGFBB, activin and PDGFAA. Suppression of proliferation occurred with TGFβ, androgen and PKA signaling...
  75. MCKEE M, Moreland C, Atcherson S, Zazove P. Hearing Loss: Communicating With the Patient Who Is Deaf or Hard of Hearing. FP Essent. 2015;434:24-8 pubmed
    ..Lipreading and note writing often are ineffective ways to communicate with deaf and hard of hearing (DHH) patients who use American Sign Language; use of medical sign language interpreters is preferred...
  76. Laughlin M, Padilla J, Jenkins N, Thorne P, Martin J, Rector R, et al. Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats. J Appl Physiol (1985). 2015;119:583-603 pubmed publisher
    ..revealed that EX induces increased expression of the following genes in all arterioles examined: Shc1, desert hedgehog protein (Dhh), adenylate cyclase 4 (Adcy4), G protein binding protein, alpha (Gnat1), and Bcl2l1 and decreased ..
  77. Cannon J, Guardino C, Gallimore E. A New Kind of Heterogeneity: What We Can Learn From d/Deaf and Hard of Hearing Multilingual Learners. Am Ann Deaf. 2016;161:8-16 pubmed publisher
    ..4%-35.0% of the U.S. d/Dhh population (Gallaudet Research Institute, 2013)...
  78. Stratton J, Kumar R, Sinha S, Shah P, Stykel M, Shapira Y, et al. Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve. Eneuro. 2017;4: pubmed publisher
    ..i>SOX9, AP2A1, CDH19, EGR1, ETV5, PAX3, SOX2, CX32, DHH, NECL4, NFATC4, POU3F1, S100B, and YY1...
  79. Canto P, Soderlund D, Reyes E, Mendez J. Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis. J Clin Endocrinol Metab. 2004;89:4480-3 pubmed
    ..the first report in which three cases of 46,XY complete PGD are attributed to mutations of the Desert hedgehog (DHH) gene...
  80. Das D, Sanghavi D, Gawde H, Idicula Thomas S, Vasudevan L. Novel homozygous mutations in Desert hedgehog gene in patients with 46,XY complete gonadal dysgenesis and prediction of its structural and functional implications by computational methods. Eur J Med Genet. 2011;54:e529-34 pubmed publisher
    ..two cases of 46,XY complete gonadal dysgenesis that could be attributable to mutations in the Desert hedgehog (DHH) gene. The mutations found in these two patients were a homozygous deletion (c...
  81. Izrailit J, Reedijk M. Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications. Cancer Lett. 2012;317:115-26 pubmed publisher
    ..Herein, we review the role of developmental pathways in stem cell biology and provide an up-to-date survey of pre-clinical and clinical trials of novel strategies to target them. ..
  82. Carpenter D, Stone D, Brush J, Ryan A, Armanini M, Frantz G, et al. Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A. 1998;95:13630-4 pubmed
    ..Because Desert Hedgehog (Dhh) is expressed specifically in the testis and is required for germ cell development, it is likely that PTCH2 ..
  83. Hegde G, Peterson K, Emanuel K, Mittal A, Joshi A, Dickinson J, et al. Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target. Mol Cancer Res. 2008;6:1928-36 pubmed publisher
    ..Together, these results reveal that Hh signaling is important in the pathogenesis of B-CLL and, hence, may be a potential therapeutic target. ..
  84. Werner R, Merz H, Birnbaum W, Marshall L, Schröder T, Reiz B, et al. 46,XY Gonadal Dysgenesis due to a Homozygous Mutation in Desert Hedgehog (DHH) Identified by Exome Sequencing. J Clin Endocrinol Metab. 2015;100:E1022-9 pubmed publisher
    ..We identified a novel homozygous R124Q mutation in the desert hedgehog gene (DHH), which alters a conserved residue among the three mammalian Hedgehog ligands sonic hedgehog, Indian hedgehog, and ..
  85. Wang F, He Q, Su K, Wei T, Xu S, Gu L. Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase. Biochem J. 2018;475:191-205 pubmed publisher
    The Asp-His-His and Asp-His-His-associated (DHH/DHHA1) domain-containing phosphodiesterases (PDEs) that catalyze degradation of cyclic di-adenosine monophosphate (c-di-AMP) could be subdivided into two subfamilies based on the final ..
  86. Meerang M, Bérard K, Felley Bosco E, Lauk O, Vrugt B, Boss A, et al. Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma. Mol Cancer Ther. 2016;15:1095-105 pubmed publisher
    ..Hh) signaling pathway has been described in malignant pleural mesothelioma (MPM), in which the ligand, desert Hh (DHH), was produced from tumor cells...
  87. Scott J, Hoffmeister R. Superordinate Precision: An Examination of Academic Writing Among Bilingual Deaf and Hard of Hearing Students. J Deaf Stud Deaf Educ. 2018;23:173-182 pubmed publisher
    ..Despite its importance, academic English is understudied with deaf and hard of hearing (DHH) students...
  88. Umehara F, Tate G, Itoh K, Yamaguchi N, Douchi T, Mitsuya T, et al. A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy. Am J Hum Genet. 2000;67:1302-5 pubmed
    ..patient, a homozygous missense mutation (ATG-->ACG) at the initiating codon in exon 1 of the desert hedgehog (DHH) gene, which predicts a failure of translation of the gene...
  89. Nakamura M, Katano M. [Hedgehog signaling pathway and its impact on development of cancer therapy]. Fukuoka Igaku Zasshi. 2008;99:102-6 pubmed
  90. Chinchilla P, Xiao L, Kazanietz M, Riobo N. Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle. 2010;9:570-79 pubmed
    ..the three Hh isoforms--Sonic Hedgehog (Shh), Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh)--signal through patched-1 (ptCH1) and Smoothened (SMo), to activate the Gli transcription factors with a ..
  91. Drexler D, Müller M, Rojas Cordova C, Bandera A, Witte G. Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima. Structure. 2017;25:1887-1897.e4 pubmed publisher
    ..We provide here structural and biochemical data on the DHH-type phosphodiesterase TmPDE (TM1595) from Thermotoga maritima...
  92. Bak M, Hansen C, Friis Henriksen K, Tommerup N. The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3. Cytogenet Cell Genet. 2001;92:300-3 pubmed
    ..HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21--> q31.3. Additionally, we have mapped murine Hhip to chromosome 8. ..