desmoplakin

Summary

Gene Symbol: desmoplakin
Description: desmoplakin
Alias: DCWHKTA, desmoplakin, 250/210 kDa paraneoplastic pemphigus antigen
Species: human
Products:     desmoplakin

Top Publications

  1. Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnolzer M, Herrmann H. Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. J Cell Sci. 2000;113 ( Pt 13):2471-83 pubmed
    ..In extracts from HaCaT cells, distinct soluble complexes containing PKP1a and desmoplakin I (DPI) have been identified by co-immunoprecipitation and sucrose density fractionation...
  2. Wan H, South A, Hart I. Increased keratinocyte proliferation initiated through downregulation of desmoplakin by RNA interference. Exp Cell Res. 2007;313:2336-44 pubmed
    ..b>Desmoplakin (Dp) is a major obligate plaque protein which plays a fundamental role in anchoring intermediate filaments to ..
  3. Uzumcu A, Norgett E, Dindar A, Uyguner O, Nisli K, Kayserili H, et al. Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome. J Med Genet. 2006;43:e5 pubmed
    ..b>Desmoplakin (DSP) is the most abundant desmosomal protein with 2 isoforms produced by alternative splicing...
  4. Godsel L, Hsieh S, Amargo E, Bass A, Pascoe McGillicuddy L, Huen A, et al. Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin. J Cell Biol. 2005;171:1045-59 pubmed
    The intermediate filament (IF)-binding protein desmoplakin (DP) is essential for desmosome function and tissue integrity, but its role in junction assembly is poorly understood...
  5. Green K, Parry D, Steinert P, Virata M, Wagner R, Angst B, et al. Structure of the human desmoplakins. Implications for function in the desmosomal plaque. J Biol Chem. 1990;265:2603-12 pubmed
    ..This suggests the possibility that the DPs might interact with IF via their common periodicity of charged residues. ..
  6. Whittock N, Ashton G, Dopping Hepenstal P, Gratian M, Keane F, Eady R, et al. Striate palmoplantar keratoderma resulting from desmoplakin haploinsufficiency. J Invest Dermatol. 1999;113:940-6 pubmed
    Recently, the first example of a human mutation in the gene encoding the desmosomal plaque protein, desmoplakin, has been described in a patient with autosomal dominant striate palmoplantar kerato-derma...
  7. Alcalai R, Metzger S, Rosenheck S, Meiner V, Chajek Shaul T. A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair. J Am Coll Cardiol. 2003;42:319-27 pubmed
    ..familial autosomal recessive ARVD, woolly hair, and a pemphigous-like skin disorder with a new mutation in the desmoplakin gene...
  8. Stappenbeck T, Bornslaeger E, Corcoran C, Luu H, Virata M, Green K. Functional analysis of desmoplakin domains: specification of the interaction with keratin versus vimentin intermediate filament networks. J Cell Biol. 1993;123:691-705 pubmed
    We previously demonstrated that truncated desmoplakin I (DP I) molecules containing the carboxyl terminus specifically coalign with and disrupt both keratin and vimentin intermediate filament (IF) networks when overexpressed in tissue ..
  9. Kowalczyk A, Bornslaeger E, Borgwardt J, Palka H, Dhaliwal A, Corcoran C, et al. The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. J Cell Biol. 1997;139:773-84 pubmed
    ..b>Desmoplakin is a desmosomal component that plays a critical role in linking intermediate filament networks to the ..

More Information

Publications86

  1. Armstrong D, McKenna K, Purkis P, Green K, Eady R, Leigh I, et al. Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma. Hum Mol Genet. 1999;8:143-8 pubmed
    ..b>Desmoplakin, a constitutive component of the desmosomal plaque, is the most abundant protein present in such junctions and ..
  2. Norgett E, Hatsell S, Carvajal Huerta L, Cabezas J, Common J, Purkis P, et al. Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. Hum Mol Genet. 2000;9:2761-6 pubmed
    ..The desmosome consists of several proteins, of which desmoplakin is the most abundant...
  3. Fontao L, Favre B, Riou S, Geerts D, Jaunin F, Saurat J, et al. Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus. Mol Biol Cell. 2003;14:1978-92 pubmed
    The bullous pemphigoid antigen 1 (BP230) and desmoplakin (DP) are members of the plakin protein family of cytolinkers. Despite their homology, their COOH termini selectively bind distinct intermediate filaments (IFs)...
  4. Bonne S, Gilbert B, Hatzfeld M, Chen X, Green K, van Roy F. Defining desmosomal plakophilin-3 interactions. J Cell Biol. 2003;161:403-16 pubmed
    ..Moreover, we determined that PKP3 interacts with plakoglobin, desmoplakin (DP) and the epithelial keratin 18...
  5. Barahona Dussault C, Benito B, Campuzano O, Iglesias A, Leung T, Robb L, et al. Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia. Clin Genet. 2010;77:37-48 pubmed publisher
  6. Yang Z, Bowles N, Scherer S, Taylor M, Kearney D, Ge S, et al. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res. 2006;99:646-55 pubmed
    ..Mutations in 6 genes, including 4 encoding desmosomal proteins (Junctional plakoglobin (JUP), Desmoplakin (DSP), Plakophilin 2, and Desmoglein 2), have been identified in patients with ARVD/C...
  7. Yang L, Chen Y, Cui T, Knösel T, Zhang Q, Albring K, et al. Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/?-catenin signaling pathway in human lung cancer. Carcinogenesis. 2012;33:1863-70 pubmed publisher
    ..As a key component of desmosomal plaque proteins, the functional role of desmoplakin (DSP) in cancer is not yet elucidated...
  8. Bornslaeger E, Corcoran C, Stappenbeck T, Green K. Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. J Cell Biol. 1996;134:985-1001 pubmed
    The desmosomal plaque protein desmoplakin (DP), located at the juncture between the intermediate filament (IF) network and the cytoplasmic tails of the transmembrane desmosomal cadherins, has been proposed to link IF to the desmosomal ..
  9. Choi H, Weis W. Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain. J Mol Biol. 2011;409:800-12 pubmed publisher
    ..b>Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments...
  10. Gomes J, Finlay M, Ahmed A, Ciaccio E, Asimaki A, Saffitz J, et al. Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Eur Heart J. 2012;33:1942-53 pubmed publisher
    ..To test this hypothesis, we investigated a murine model with conditional cardiac genetic deletion of one desmoplakin allele (DSP ±) and compared the findings to patients with non-diagnostic features of ARVC who carried ..
  11. Rampazzo A, Nava A, Malacrida S, Beffagna G, Bauce B, Rossi V, et al. Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet. 2002;71:1200-6 pubmed
    ..unlinked to any of the six different ARVD loci reported so far; we identify a mutation (S299R) in exon 7 of desmoplakin (DSP), which modifies a putative phosphorylation site in the N-terminal domain binding plakoglobin...
  12. Bauce B, Basso C, Rampazzo A, Beffagna G, Daliento L, Frigo G, et al. Clinical profile of four families with arrhythmogenic right ventricular cardiomyopathy caused by dominant desmoplakin mutations. Eur Heart J. 2005;26:1666-75 pubmed
    ..ventricular cardiomyopathy (ARVC) due to mutations of the gene encoding for the cell-to-cell adhesion protein desmoplakin (DSP)...
  13. Smith E, Fuchs E. Defining the interactions between intermediate filaments and desmosomes. J Cell Biol. 1998;141:1229-41 pubmed
    b>Desmoplakin (DP), plakoglobin (PG), and plakophilin 1 (PP1) are desmosomal components lacking a transmembrane domain, thus making them candidate linker proteins for connecting intermediate filaments and desmosomes...
  14. Choi H, Park Snyder S, Pascoe L, Green K, Weis W. Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat Struct Biol. 2002;9:612-20 pubmed
    ..b>Desmoplakin is a member of the plakin family of IF-binding proteins...
  15. Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E. Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol. 2001;3:1076-85 pubmed
    We have generated an epidermis-specific desmoplakin (DP) mouse knockout, and show that epidermal integrity requires DP; mechanical stresses to DP-null skin cause intercellular separations...
  16. den Haan A, Tan B, Zikusoka M, Lladó L, Jain R, Daly A, et al. Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Cardiovasc Genet. 2009;2:428-35 pubmed publisher
    ..Compared with those without a desmosome gene mutation, individuals with a desmosome gene mutation had earlier-onset ARVD/C and were more likely to have ventricular tachycardia. ..
  17. Meng J, Bornslaeger E, Green K, Steinert P, Ip W. Two-hybrid analysis reveals fundamental differences in direct interactions between desmoplakin and cell type-specific intermediate filaments. J Biol Chem. 1997;272:21495-503 pubmed
    ..Previous studies demonstrated that the COOH terminus of the desmosomal plaque protein, desmoplakin (DP), is required for the association of DP with IF networks in cultured cells and that this domain interacts ..
  18. Al Owain M, Wakil S, Shareef F, Al Fatani A, Hamadah E, Haider M, et al. Novel homozygous mutation in DSP causing skin fragility-woolly hair syndrome: report of a large family and review of the desmoplakin-related phenotypes. Clin Genet. 2011;80:50-8 pubmed publisher
    b>Desmoplakin is an important cytoskeletal linker for the function of the desmosomes. Linking desmoplakin to certain types of cardiocutaneous syndromes has been a hot topic recently...
  19. Cabral R, Tattersall D, Patel V, McPhail G, Hatzimasoura E, Abrams D, et al. The DSPII splice variant is crucial for desmosome-mediated adhesion in HaCaT keratinocytes. J Cell Sci. 2012;125:2853-61 pubmed publisher
    ..Defective desmosomal function due to inherited mutations in the constitutive desmosomal gene desmoplakin (DSP) causes skin or heart disorders and in some instances both...
  20. Chen X, Bonne S, Hatzfeld M, van Roy F, Green K. Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling. J Biol Chem. 2002;277:10512-22 pubmed
    ..Here we show that plakophilin 2 can interact directly with several desmosomal components, including desmoplakin, plakoglobin, desmoglein 1 and 2, and desmocollin 1a and 2a...
  21. Jonkman M, Pasmooij A, Pasmans S, van den Berg M, Ter Horst H, Timmer A, et al. Loss of desmoplakin tail causes lethal acantholytic epidermolysis bullosa. Am J Hum Genet. 2005;77:653-60 pubmed
    The cytoplasmic plaque protein desmoplakin (DP), which is located in desmosomes, plays a major role in epithelial and muscle cell adhesion by linking the transmembrane cadherins to the cytoplasmic intermediate filament network...
  22. Norgett E, Lucke T, Bowers B, Munro C, Leigh I, Kelsell D. Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin. J Invest Dermatol. 2006;126:1651-4 pubmed
  23. Whittock N, Wan H, Morley S, Garzon M, Kristal L, Hyde P, et al. Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome. J Invest Dermatol. 2002;118:232-8 pubmed
    The constitutive desmosomal plaque protein desmoplakin plays a vital part in keratinocyte adhesion in linking the transmembranous desmosomal cadherins to the cytoplasmic keratin filament network...
  24. Al Jassar C, KNOWLES T, Jeeves M, Kami K, Behr E, Bikker H, et al. The nonlinear structure of the desmoplakin plakin domain and the effects of cardiomyopathy-linked mutations. J Mol Biol. 2011;411:1049-61 pubmed publisher
    b>Desmoplakin is a cytoplasmic desmosomal protein that plays a vital role in normal intercellular adhesion...
  25. Kouklis P, Hutton E, Fuchs E. Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol. 1994;127:1049-60 pubmed
    ..b>Desmoplakin (DPI), a desmosomal component lacking a transmembrane domain, has been implicated in this interaction, although ..
  26. Stappenbeck T, Lamb J, Corcoran C, Green K. Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks. J Biol Chem. 1994;269:29351-4 pubmed
    ..These results suggest that phosphorylation of a specific residue in the DP COOH terminus may negatively regulate its interaction with keratin IF networks. ..
  27. Bass Zubek A, Hobbs R, Amargo E, Garcia N, Hsieh S, Chen X, et al. Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. J Cell Biol. 2008;181:605-13 pubmed publisher
    ..plaque of intercellular junctions and participate in linking the intermediate filament (IF)-binding protein desmoplakin (DP) to desmosomal cadherins...
  28. Virata M, Wagner R, Parry D, Green K. Molecular structure of the human desmoplakin I and II amino terminus. Proc Natl Acad Sci U S A. 1992;89:544-8 pubmed
  29. Norman M, Simpson M, Mogensen J, Shaw A, Hughes S, Syrris P, et al. Novel mutation in desmoplakin causes arrhythmogenic left ventricular cardiomyopathy. Circulation. 2005;112:636-42 pubmed
    ..Several disease loci have been identified. Mutations in desmoplakin have recently been isolated in both autosomal-dominant and autosomal-recessive forms of ARVC...
  30. Ishibashi Y, Matsui T, Takeuchi M, Yamagishi S. Rosuvastatin blocks advanced glycation end products-elicited reduction of macrophage cholesterol efflux by suppressing NADPH oxidase activity via inhibition of geranylgeranylation of Rac-1. Horm Metab Res. 2011;43:619-24 pubmed publisher
  31. Presland R, Dale B. Epithelial structural proteins of the skin and oral cavity: function in health and disease. Crit Rev Oral Biol Med. 2000;11:383-408 pubmed
    ..desmosomal cadherins are linked to the keratin cytoskeleton via several cytoplasmic plaque proteins, including desmoplakin and plakoglobin (gamma-catenin)...
  32. Dash P, Agarwal A, Sharma S, Saha A, Joshi G, Gopalan N, et al. Development of a SYBR green I-based quantitative RT-PCR for Ross River virus: Application in vector competence studies and antiviral drug evaluation. J Virol Methods. 2016;234:107-14 pubmed publisher
    ..aegypti are well competent to transmit RRV highlighting the risk of its introduction to naïve territories across continents. Further validation of this assay, revealed its utility in screening of potential antivirals against RRV. ..
  33. Tamba M, Caminiti A, Prosperi A, Despres P, Lelli D, Galletti G, et al. Accuracy estimation of an indirect ELISA for the detection of West Nile Virus antibodies in wild birds using a latent class model. J Virol Methods. 2017;248:202-206 pubmed publisher
  34. Callaghan B, Xia R, Reynolds E, Banerjee M, Burant C, Rothberg A, et al. Better diagnostic accuracy of neuropathy in obesity: A new challenge for neurologists. Clin Neurophysiol. 2018;129:654-662 pubmed publisher
    ..Select few small fiber nerve measures performed well for SFN, and none for CAN. Specific combinations of tests should be used for research studies to maximize diagnostic performance in obese cohorts. ..
  35. Takemae N, Tsunekuni R, Uchida Y, Ito T, Saito T. Experimental infection of pigs with H1 and H3 influenza A viruses of swine by using intranasal nebulization. BMC Vet Res. 2018;14:115 pubmed publisher
    ..Our current findings show that intranasal nebulization successfully established IAV-S infections in pigs and demonstrate that clinical signs, viral shedding, and host immune responses varied among the strains inoculated. ..
  36. Yang G, Yuan G, Macdougall M, Zhi C, Chen S. BMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts. Sci Rep. 2017;7:10775 pubmed publisher
    ..In conclusion, in this study we found a novel signaling pathway in which BMP-2 activates Dspp gene transcription via Dlx3/Osx pathway. ..
  37. del Campo M, Zhong T, Tampe R, Garcia L, Lagos N. Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells: Negative health consequences. Toxicon. 2017;126:23-31 pubmed publisher
    ..The inflammatory profile produced by DTX-1 is shown for the first time. The safe limit regulation should be changed to DSP toxins zero tolerance in the shellfish to be consumed by humans. ..
  38. Johnson S, Harrison K, Turner A. Application of rapid test kits for the determination of Diarrhetic Shellfish Poisoning (DSP) toxins in bivalve molluscs from Great Britain. Toxicon. 2016;111:121-9 pubmed publisher
    ..Further work is required however using a larger number of test kit batches on a greater number of samples, particularly for those containing high proportions of DTX2. ..
  39. Zhang Y, Storey K. Expression of nuclear factor of activated T cells (NFAT) and downstream muscle-specific proteins in ground squirrel skeletal and heart muscle during hibernation. Mol Cell Biochem. 2016;412:27-40 pubmed publisher
  40. Andrianopoulos V, Wouters E, Pinto Plata V, Vanfleteren L, Bakke P, Franssen F, et al. Prognostic value of variables derived from the six-minute walk test in patients with COPD: Results from the ECLIPSE study. Respir Med. 2015;109:1138-46 pubmed publisher
    ..25], BODE index ≥3 points [1.40]; all p ≤ 0.05). The 6 MWT-derived variables have an additional predictive value of mortality in patients with COPD. The 6 MWW, EID and the BODE index refine the prognosis of hospitalization. ..
  41. Melaiu O, Melissari E, Mutti L, Bracci E, De Santi C, Iofrida C, et al. Expression status of candidate genes in mesothelioma tissues and cell lines. Mutat Res. 2015;771:6-12 pubmed publisher
    ..Although MPM is a poorly studied cancer, some features are starting to emerge. Novel cancer genes are suggested here, in particular those involved in cell-cell and cell-matrix interactions. ..
  42. Ujevic I, Vuletić N, Lušić J, Nazlić N, Kuspilić G. Bioaccumulation of trace metals in mussel (Mytilus galloprovincialis) from Mali Ston Bay during DSP toxicity episodes. Molecules. 2015;20:13031-40 pubmed publisher
    ..Cd, Cr, Zn and Ni show higher values in approximately 75% of the DSP positive samples, whereas for Pb and Cr the values were 26% and 34%, respectively. This trend was unchanged during the whole observation period. ..
  43. Just M, Herbst H, Hummel M, Durkop H, Tripier D, Stein H, et al. Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins. J Biol Chem. 1991;266:17326-32 pubmed
    ..Furthermore, as in fibronectin and tenascin, undulin bears an additional subset of interactive domains tailored to specific structural and functional roles in development and differentiation. ..
  44. Yu J, Li L, Xie G, Zhang C, Ao Y, Duan Z. Experimental infection of Marmota monax with a novel hepatitis A virus. Arch Virol. 2018;163:1187-1193 pubmed publisher
    ..MHHAV can infect M. monax and is associated with hepatic disease. Therefore, this animal can be used as a model of HAV pathogenesis and to evaluate antiviral and anticancer therapeutics. ..
  45. Hu P, Ma L, Wang Y, Ye F, Wang C, Zhou W, et al. Genistein, a dietary soy isoflavone, exerts antidepressant-like effects in mice: Involvement of serotonergic system. Neurochem Int. 2017;108:426-435 pubmed publisher
    ..Serotonergic system that preferentially couples with 5-HT1A receptors may be critically responsible for the present genistein anti-depression. ..
  46. Pomorska Mól M, Dors A, Kwit K, Kowalczyk A, Stasiak E, Pejsak Z. Kinetics of single and dual infection of pigs with swine influenza virus and Actinobacillus pleuropneumoniae. Vet Microbiol. 2017;201:113-120 pubmed publisher
    ..Enhanced SIV replication contributed to a more severe clinical course of the disease as well as earlier and higher magnitude immune response (acute phase proteins, HI antibodies) compared to single inoculated pigs. ..
  47. Lamovšek J, Stare B, Plesko I, Širca S, Urek G. Agrobacteria Enhance Plant Defense Against Root-Knot Nematodes on Tomato. Phytopathology. 2017;107:681-691 pubmed publisher
    ..We conclude that the observed antagonism in the tested pathosystem was the result of initially strong plant defense that was later suppressed by the invading pathogen and pest. ..
  48. Faulhammer E, Wahl V, Zellnitz S, Khinast J, Paudel A. Carrier-based dry powder inhalation: Impact of carrier modification on capsule filling processability and in vitro aerodynamic performance. Int J Pharm. 2015;491:231-42 pubmed publisher
    ..8%) and the in vitro aerodynamic performance (FPF of 12%). ..
  49. Cai X, Yang Y, Xie X, Yu F, Yang Y, Yang Z, et al. Preparation, characterization and pulmonary pharmacokinetics of a new inhalable zanamivir dry powder. Drug Deliv. 2016;23:1962-71 pubmed publisher
    ..The results indicated that the zanamivir DPIs were effectively delivered to the lung. These results indicate that the spray-dried zanamivir DPIs were promising for pulmonary delivery. ..
  50. Kinnunen H, Hebbink G, Peters H, Huck D, Makein L, Price R. Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition. Int J Pharm. 2015;478:53-9 pubmed publisher
    ..These results suggest drug-fines agglomerate formation is an important mechanism for how lactose fines improve and regulate DPI formulation performance. ..
  51. Kolanjiyil A, Kleinstreuer C, Sadikot R. Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part II: Dry powder inhaler application. Comput Biol Med. 2017;84:247-253 pubmed publisher
    ..This study is the first to utilize CF-PD methodology to simulate drug-aerosol transport and deposition under actual breathing conditions in a whole lung model, using a commercial dry-powder inhaler for realistic inlet conditions. ..
  52. Szilagyi J, Mishin V, Heck D, Jan Y, Aleksunes L, Richardson J, et al. Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium. Toxicol Sci. 2016;151:150-9 pubmed publisher
    ..Increased sensitivity for inhibition of CYP-mediated metabolism and nitric oxide production by iNOS indicates that DPI targets heme moieties within the enzymes. ..
  53. Nam J, Shim S, Song E, Españo E, Jeong D, Song D, et al. Rapid virulence shift of an H5N2 avian influenza virus during a single passage in mice. Arch Virol. 2017;162:3017-3024 pubmed publisher
  54. Hara S, Kobayashi M, Kuriiwa F, Ikematsu K, Mizukami H. Hydroxyl radical production via NADPH oxidase in rat striatum due to carbon monoxide poisoning. Toxicology. 2018;394:63-71 pubmed publisher
    ..There were no significant changes in the protein levels of NOX1 through NOX4 and Rac1. It is likely that the CO-induced OH production is mediated through the activation of Rac-dependent NOX enzymes, such as Nox1, Nox2, and Nox3. ..
  55. Kazerounian S, Uitto J, Aho S. Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin. Exp Dermatol. 2002;11:428-38 pubmed
    Plectin, desmoplakin, and the 230-kDa bullous pemphigoid antigen (BPAG1), members of the plakin family of proteins, are multifunctional cytolinkers, connecting the cytoskeletal structures to the cell adhesion complexes...
  56. Hassan K, Ali A, Shany S, el Kady M. Experimental co-infection of infectious bronchitis and low pathogenic avian influenza H9N2 viruses in commercial broiler chickens. Res Vet Sci. 2017;115:356-362 pubmed publisher
    ..In conclusion, co-infection of IBV and AIV-H9N2 induced severe clinical outcome and high mortality. Also, IBV co-infection increased the shedding of AIV-H9N2 in experimentally infected birds. ..
  57. Prego Faraldo M, Valdiglesias V, Laffon B, Mendez J, Eirín López J. Early Genotoxic and Cytotoxic Effects of the Toxic Dinoflagellate Prorocentrum lima in the Mussel Mytilus galloprovincialis. Toxins (Basel). 2016;8: pubmed publisher
    ..lima. In doing so, it also demonstrates for the first time the potential of the modified (OGG1) comet assay for assessing oxidative DNA damage caused by marine toxins in marine invertebrates. ..
  58. Jetzer M, Morrical B, Fergenson D, Imanidis G. Particle interactions of fluticasone propionate and salmeterol xinafoate detected with single particle aerosol mass spectrometry (SPAMS). Int J Pharm. 2017;532:218-228 pubmed publisher
    ..Another significant finding was that rather coarse fluticasone particles (in DPI) and fine salmeterol particles (both MDI and DPI) were forming the particle co-associations. ..
  59. Jia H, Zhang Y, Orbović V, Xu J, White F, Jones J, et al. Genome editing of the disease susceptibility gene CsLOB1 in citrus confers resistance to citrus canker. Plant Biotechnol J. 2017;15:817-823 pubmed publisher
    ..No side effects and off-target mutations were detected in the mutated plants. This study indicates that genome editing using CRISPR technology will provide a promising pathway to generate disease-resistant citrus varieties...
  60. Zhang S, Xiang J, Theuns S, Desmarets L, Trus I, Nauwynck H. MCMV exploits the spleen as a transfer hub for systemic dissemination upon oronasal inoculation. Virus Res. 2016;217:47-54 pubmed publisher
    ..Taken together, all these data clearly demonstrate that virus dissemination to distant organs is reduced in splenectomized mice, further confirming the importance of the spleen as a viremia booming site for a natural MCMV infection. ..
  61. Anhalt G, Kim S, Stanley J, Korman N, Jabs D, Kory M, et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med. 1990;323:1729-35 pubmed
    ..The 250-kd polypeptide comigrated with desmoplakin I (a protein found in the desmosomes of all epithelia), and the 230-kd antigen comigrated with the antigen of ..
  62. Bernardes D, Oliveira A. Comprehensive catwalk gait analysis in a chronic model of multiple sclerosis subjected to treadmill exercise training. BMC Neurol. 2017;17:160 pubmed publisher
  63. Jang S, Yayeh T, Leem Y, Park E, Ito Y, Oh S. Concanavalin A Induces Cortical Neuron Apoptosis by Causing ROS Accumulation and Tyrosine Kinase Activation. Neurochem Res. 2017;42:3504-3514 pubmed publisher
    ..Interestingly, Con A-induced cellular damage was observed in cortical neurons but not in astrocytes or microglia. ..
  64. Ouwendijk W, Getu S, Mahalingam R, Gilden D, Osterhaus A, Verjans G. Characterization of the immune response in ganglia after primary simian varicella virus infection. J Neurovirol. 2016;22:376-88 pubmed publisher
    ..Overall, local immune responses emerged as viral DNA load in ganglia declined, suggesting that intra-ganglionic immunity contributes to restricting SVV replication. ..
  65. Sato Akaba H, Emoto M, Hirata H, Fujii H. Design and testing of a 750MHz CW-EPR digital console for small animal imaging. J Magn Reson. 2017;284:48-58 pubmed publisher
    ..All DSP tasks were carried out in field programmable gate array ICs. In vivo 3D imaging of nitroxyl radicals in a mouse's head was successfully performed. ..
  66. Asghar M, Palinauskas V, Zaghdoudi Allan N, Valkiunas G, Mukhin A, Platonova E, et al. Parallel telomere shortening in multiple body tissues owing to malaria infection. Proc Biol Sci. 2016;283: pubmed publisher
    ..Our results have far-reaching implications for understanding how the short-term effects of an infection can translate into long-term costs, such as organ dysfunction, degenerative diseases, and ageing. ..
  67. Adhikari P, Cosby D, Cox N, Kim W. Effect of dietary supplementation of nitrocompounds on Salmonella colonization and ileal immune gene expression in laying hens challenged with Salmonella Enteritidis. Poult Sci. 2017;: pubmed publisher
    ..Overall, nitrocompounds such as NE and NP can be used in the intervention strategy to reduce Salmonella infection in hens...
  68. Tessier S, Zhang Y, Wijenayake S, Storey K. MAP kinase signaling and Elk1 transcriptional activity in hibernating thirteen-lined ground squirrels. Biochim Biophys Acta Gen Subj. 2017;1861:2811-2821 pubmed publisher
    ..We identify regulation of JNK and Elk1 in the skeletal muscle of hibernating I. tridecemlineatus. ..
  69. Patel P, Kadur Narayanaswamy G, Kataria S, Baghel L. Involvement of nitric oxide in enhanced germination and seedling growth of magnetoprimed maize seeds. Plant Signal Behav. 2017;:e1293217 pubmed publisher
    ..amylase activity was also inhibited by all the 3 inhibitors used. It is concluded that NO inhibitors and ROS inhibitor inhibited magnetic field induced promotion of seedling parameters and ?- amylase activity of maize seeds...
  70. Pavulraj S, Virmani N, Bera B, Joshi A, Anand T, Virmani M, et al. Immunogenicity and protective efficacy of inactivated equine influenza (H3N8) virus vaccine in murine model. Vet Microbiol. 2017;210:188-196 pubmed publisher
    ..In addition, BALB/c mouse can serve as an attractive tool for adjudging protective efficacy of vaccine candidates prior to final testing in equines. ..
  71. Palmieri A, Avantaggiato A, Cura F, Papalia R, Casale M, Bressi F, et al. Effect of biostimulation on oral fibroblast: a pilot study. J Biol Regul Homeost Agents. 2017;31: pubmed
    ..Both the treatments were responsible for Elastine and Desmoplakin genes activation...
  72. Wang L, Zhang C, Su X, Lin D, Wu P, Schwartzman M, et al. PGF2? regulates the basolateral K channels in the distal convoluted tubule. Am J Physiol Renal Physiol. 2017;313:F254-F261 pubmed publisher
    ..We conclude that PGF2? at low doses stimulates the basolateral 40-pS K channel by a NOX- and SFK-dependent mechanism, while at high concentrations, it inhibits the K channel by a PKC-dependent pathway. ..
  73. Jung M, Jung S. Gene expression regulation of the TLR9 and MyD88-dependent pathways in rock bream against rock bream iridovirus (RBIV) infection. Fish Shellfish Immunol. 2017;70:507-514 pubmed publisher
    ..This is a critical factor for RBIV disease recovery; however, these immune responses did not efficiently respond in fish dead condition (high mortality group). ..
  74. Lin K, Totoev Y, Liu H, Guo T. In-Plane Behaviour of a Reinforcement Concrete Frame with a Dry Stack Masonry Panel. Materials (Basel). 2016;9: pubmed publisher
    ..The constant friction stage was verified to provide substantial energy dissipation and benefits to the ductility of the structure, which, therefore, is suggested to be prolonged in reality. ..
  75. Hsieh J, Chuah A, Patel H, Sandhu K, Foley W, Külheim C. Transcriptome Profiling of Melaleuca quinquenervia Challenged by Myrtle Rust Reveals Differences in Defense Responses among Resistant Individuals. Phytopathology. 2017;: pubmed publisher
    ..psidii resistance-related genes such as RLK, NBS-LRR proteins, GST, WRKY and PR proteins. We identified large differences in the expression of defense-related genes among resistant individuals...
  76. Cox M, van der Smagt J, Noorman M, Wiesfeld A, Volders P, van Langen I, et al. Arrhythmogenic right ventricular dysplasia/cardiomyopathy diagnostic task force criteria: impact of new task force criteria. Circ Arrhythm Electrophysiol. 2010;3:126-33 pubmed publisher
    ..were found: 58 in the gene encoding Plakophilin2 (PKP2), 3 in Desmoglein2, 3 in Desmocollin2, and 1 in Desmoplakin. Three patients had bigenic involvement...
  77. Dehner C, Rötzer V, Waschke J, Spindler V. A desmoplakin point mutation with enhanced keratin association ameliorates pemphigus vulgaris autoantibody-mediated loss of cell cohesion. Am J Pathol. 2014;184:2528-36 pubmed publisher
    b>Desmoplakin (DP) serves to anchor intermediate filaments in desmosomal complexes...