desmin

Summary

Gene Symbol: desmin
Description: desmin
Alias: CSM1, CSM2, LGMD2R, intermediate filament protein, mutant desmin p.K241E
Species: human

Top Publications

  1. ncbi An overlapping CArG/octamer element is required for regulation of desmin gene transcription in arterial smooth muscle cells
    M Mericskay
    Laboratoire de Biologie Moléculaire de la Différenciation, Universite Denis Diderot Paris 7, 2, place Jussieu, Paris, 75005, France
    Dev Biol 226:192-208. 2000
  2. pmc Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutation
    Carola Hedberg
    Department of Pathology, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Eur J Hum Genet 20:984-5. 2012
  3. doi Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene
    J Peter van Tintelen
    Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Rhythm 6:1574-83. 2009
  4. pmc Desmin-related cardiomyopathy: an unfolding story
    Patrick M McLendon
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Heart Circ Physiol 301:H1220-8. 2011
  5. ncbi Missense mutations in desmin associated with familial cardiac and skeletal myopathy
    L G Goldfarb
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Nat Genet 19:402-3. 1998
  6. pmc Dual color photoactivation localization microscopy of cardiomyopathy-associated desmin mutants
    Andreas Brodehl
    E and H Klessmann Institute for Cardiovascular Research and Development, Ruhr University Bochum, 32545 Bad Oeynhausen, Germany
    J Biol Chem 287:16047-57. 2012
  7. pmc Desmin A213V substitution represents a rare polymorphism but not a mutation and is more prevalent in patients with heart dilation of various origins
    A Kostareva
    Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    Acta Myol 30:42-5. 2011
  8. pmc Interactive sequences in the stress protein and molecular chaperone human alphaB crystallin recognize and modulate the assembly of filaments
    Joy G Ghosh
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, United States
    Int J Biochem Cell Biol 39:1804-15. 2007
  9. doi Divergent molecular effects of desmin mutations on protein assembly in myofibrillar myopathy
    Johannes Levin
    Klinikum Grosshadern, Department of Neurology, Ludwig Maximilians University of Munich, Munich, Germany
    J Neuropathol Exp Neurol 69:415-24. 2010
  10. ncbi Desmin mutations in a St. Petersburg cohort of cardiomyopathies
    A Kostareva
    Department of Woman and Child Health, and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Acta Myol 25:109-15. 2006

Detail Information

Publications209 found, 100 shown here

  1. ncbi An overlapping CArG/octamer element is required for regulation of desmin gene transcription in arterial smooth muscle cells
    M Mericskay
    Laboratoire de Biologie Moléculaire de la Différenciation, Universite Denis Diderot Paris 7, 2, place Jussieu, Paris, 75005, France
    Dev Biol 226:192-208. 2000
    The desmin gene encodes an intermediate filament protein that is present in skeletal, cardiac, and smooth muscle cells...
  2. pmc Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutation
    Carola Hedberg
    Department of Pathology, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Eur J Hum Genet 20:984-5. 2012
    ..A heterozygous C-to-T transition, c.1255C>T, p.Pro419Ser in the desmin gene on chromosome 2q35, was identified. Previous studies had demonstrated linkage to chromosome 10q22...
  3. doi Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene
    J Peter van Tintelen
    Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Rhythm 6:1574-83. 2009
    ..Mutations in the gene encoding desmin (DES), a major intermediate filament protein, can underlie this phenotype.
  4. pmc Desmin-related cardiomyopathy: an unfolding story
    Patrick M McLendon
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Heart Circ Physiol 301:H1220-8. 2011
    The intermediate filament protein desmin is an integral component of the cardiomyocyte and serves to maintain the overall structure and cytoskeletal organization within striated muscle cells...
  5. ncbi Missense mutations in desmin associated with familial cardiac and skeletal myopathy
    L G Goldfarb
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Nat Genet 19:402-3. 1998
    b>Desmin-related myopathy (OMIM 601419) is a familial disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias and restrictive heart failure, and by intracytoplasmic accumulation of desmin-..
  6. pmc Dual color photoactivation localization microscopy of cardiomyopathy-associated desmin mutants
    Andreas Brodehl
    E and H Klessmann Institute for Cardiovascular Research and Development, Ruhr University Bochum, 32545 Bad Oeynhausen, Germany
    J Biol Chem 287:16047-57. 2012
    Mutations in the DES gene coding for the intermediate filament protein desmin may cause skeletal and cardiac myopathies, which are frequently characterized by cytoplasmic aggregates of desmin and associated proteins at the cellular level...
  7. pmc Desmin A213V substitution represents a rare polymorphism but not a mutation and is more prevalent in patients with heart dilation of various origins
    A Kostareva
    Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    Acta Myol 30:42-5. 2011
    Several desmin mutations have been described in patients with cardiomyopathies and distal myopathies...
  8. pmc Interactive sequences in the stress protein and molecular chaperone human alphaB crystallin recognize and modulate the assembly of filaments
    Joy G Ghosh
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, United States
    Int J Biochem Cell Biol 39:1804-15. 2007
    ..in human alphaB crystallin that selectively interacted with native or partially unfolded filament proteins desmin, glial-fibrillary acidic protein, and actin...
  9. doi Divergent molecular effects of desmin mutations on protein assembly in myofibrillar myopathy
    Johannes Levin
    Klinikum Grosshadern, Department of Neurology, Ludwig Maximilians University of Munich, Munich, Germany
    J Neuropathol Exp Neurol 69:415-24. 2010
    Mutations in the intermediate filament protein desmin cause a distinct class of myofibrillar myopathies that are characterized by deposition of aggregated desmin...
  10. ncbi Desmin mutations in a St. Petersburg cohort of cardiomyopathies
    A Kostareva
    Department of Woman and Child Health, and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Acta Myol 25:109-15. 2006
    Several desmin mutations have been described over the past few years in patients with dilated and restrictive cardiomyopathy, often in association with distal myopathy...
  11. pmc A dysfunctional desmin mutation in a patient with severe generalized myopathy
    A M Munoz-Marmol
    Fundación Echevarne, 08037 Barcelona, Spain
    Proc Natl Acad Sci U S A 95:11312-7. 1998
    Mice lacking desmin produce muscle fibers with Z disks and normal sarcomeric organization. However, the muscles are mechanically fragile and degenerate upon repeated contractions...
  12. ncbi The enlarging spectrum of desminopathies: new morphological findings, eastward geographic spread, novel exon 3 desmin mutation
    Alexandra Vrabie
    Department of Neuropathology, Johannes Gutenberg University Medical Center, Langenbeckstrasse 1, 55101 Mainz, Germany
    Acta Neuropathol 109:411-7. 2005
    ..of the older brother revealed granulofilamentous material and plaques containing numerous proteins, foremost desmin, as did cardiac biopsy tissue...
  13. pmc Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements
    Wei Jiang
    College of Bioinformatics Science and Technology and Bio pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, PR China
    BMC Syst Biol 2:72. 2008
    ..The aim of this study was thus to develop such a novel networking approach based on the relevance concept, which is ideal to reveal integrative effects of multiple genes in the underlying genetic circuit for complex diseases...
  14. pmc Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein
    R L Shoeman
    Max Planck Institut für Zellbiologie, Abteilung Traub, Rosenhof, Federal Republic of Germany
    Proc Natl Acad Sci U S A 87:6336-40. 1990
    The intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein are cleaved in vitro by human immunodeficiency virus type 1 protease (HIV-1 PR)...
  15. ncbi Prevalence of desmin mutations in dilated cardiomyopathy
    Matthew R G Taylor
    University of Colorado at Denver and Health Sciences Center, Denver, Colo, USA
    Circulation 115:1244-51. 2007
    b>Desmin-related myofibrillar myopathy (DRM) is a cardiac and skeletal muscle disease caused by mutations in the desmin (DES) gene...
  16. ncbi The human desmin locus: gene organization and LCR-mediated transcriptional control
    Jennifer L Y Tam
    Nuclear Biology Group, Department of Medical and Molecular Genetics, King s College London School of Medicine, King s College London Guy s Campus, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Genomics 87:733-46. 2006
    ..We report the first characterization of a muscle-cell-specific LCR, which is linked to the human desmin gene (DES)...
  17. ncbi Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments
    H Inada
    Division of Biochemistry, Aichi Cancer Center Research Institute, 1 1 Chikusa ku, Nagoya, Aichi 464 8681, Japan
    J Biol Chem 274:34932-9. 1999
    ..The balance between intermediate filament protein phosphorylation by Rho kinase and dephosphorylation by type 1 protein phosphatase may affect the ..
  18. pmc Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin
    R L Shoeman
    Max Planck Institut für Zellbiologie, Ladenburg, Federal Republic of Germany
    Am J Pathol 142:221-30. 1993
    ..myofibrils treated in vitro with human immunodeficiency virus type 1 protease showed that myosin heavy chain, desmin, tropomyosin, and a fraction of the actin were all cleaved...
  19. ncbi Human desmin gene: cDNA sequence, regional localization and exclusion of the locus in a familial desmin-related myopathy
    P Vicart
    Universite Paris VII, Paris, France
    Hum Genet 98:422-9. 1996
    b>Desmin is a muscle-specific intermediate filament that is encoded by a gene assigned to human chromosome 2q35. Desmin-related myopathies are inherited disorders characterized by an intrasarcoplasmic accumulation of desmin...
  20. ncbi Expression of the intermediate filament protein synemin in myofibrillar myopathies and other muscle diseases
    Montse Olive
    Institut de Neuropatologia, Ciutat Sanitaria i Universitaria de Bellvitge, C Feixa Llarga s n masculine, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 106:1-7. 2003
    ..skeletal and cardiac muscles have demonstrated that synemin localises at the Z-band, where it associates with desmin and alpha-actinin...
  21. pmc Bradykinin B2 receptors and coupling mechanisms in the smooth muscle of the guinea-pig taenia caeci
    J L Field
    Biomedical Sciences Division, King s College London, Chelsea, London
    Br J Pharmacol 113:607-13. 1994
    ..A possible causal relationship is suggested between these B2 receptor-mediated membrane potential-dependent, and -independent events,and their roles in excitation contraction coupling...
  22. pmc Investigations into the mechanism of vasoconstrictor action of the topical steroid betamethasone-17-valerate in the rat
    A Ahluwalia
    Department of Biochemical Pharmacology, William Harvey Research Institute, St Bartholomew s Medical College, London
    Br J Pharmacol 108:544-8. 1993
    ....
  23. ncbi Glucagon inhibits ACTH-stimulated cortisol secretion from dispersed human adrenocortical cells by activating unidentified receptors negatively coupled with the adenylate cyclase cascade
    G Mazzocchi
    Department of Human Anatomy and Physiology, University of Padua, Italy
    Horm Metab Res 32:265-8. 2000
    ..Taken together, these findings suggest that glucagon, through the activation of unidentified receptors located on ZF/R cells, inhibits adenylate cyclase, thereby dampening glucocorticoid response to ACTH...
  24. pmc Involvement of B2 receptors in the bradykinin-induced relaxation of guinea-pig isolated trachea
    A da Silva
    Laboratoire de Neuroimmunopharmacologie, INSERM U405, , , Illkirch, France
    Br J Pharmacol 114:103-8. 1995
    ..The stimulation of B2-bradykinin receptors induces the activation of the cyclo-oxygenase pathway, leading either to contraction or relaxation depending on the tone of the trachea...
  25. ncbi Repellent activity of estrogenic compounds toward zoospores of the phytopathogenic fungus Aphanomyces cochlioides
    M T Islam
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Z Naturforsch C 56:253-61. 2001
    ..So far, this will be the first report of repellent activity of estrogenic compounds toward trivial fungal zoospores...
  26. pmc Involvement of B1 and B2 receptors in bradykinin-induced rat paw oedema
    M M Campos
    Department of Pharmacology, Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 114:1005-13. 1995
    ..Such mechanisms may be relevant for the manifestation of acute and chronic inflammatory processes...
  27. pmc Mediation by bradykinin of rat paw oedema induced by collagenase from Clostridium histolyticum
    F J Legat
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Br J Pharmacol 112:453-60. 1994
    ..The present results might provide an experimental basis for clinical investigations of the effects of icatibant in infectious diseases where the release of collagenases from bacteria causes rapid spreading of inflammation...
  28. ncbi A randomized trial of chemotherapy with or without estrogenic recruitment in locally advanced breast cancer. North-West Oncology Group (GONO) Study, Italy
    E Baldini
    U.O. Oncologia Medica, Pisa, Italy
    Tumori 83:829-33. 1997
    ..Further research is needed to investigate different schedules of chemotherapy and hormones, or to test the possibility of combining various mitogens...
  29. pmc The effect of in vivo oestrogen pretreatment on the contractile response of rat isolated detrusor muscle
    R A Elliott
    Department of Medicine for the Elderly, Leicester General Hospital
    Br J Pharmacol 107:766-70. 1992
    ..8. These results suggest that oestradiol pretreatment had a modulating effect on cholinergic responses.The addition of oestrogen to the tissue environment enhances this inhibitory effect...
  30. doi Desmin mutations in the terminal consensus motif prevent synemin-desmin heteropolymer filament assembly
    Oussama Chourbagi
    University Paris Diderot Paris 7 CNRS EAC4413, Unit of Functional and Adaptive Biology, Laboratory of Stress and Pathologies of the Cytoskeleton, F 75013, Paris, France
    Exp Cell Res 317:886-97. 2011
    ..Synemin is a desmin-associated type VI intermediate filament protein. Neither its impact on desmin network nor how it integrates into desmin filament is yet elucidated...
  31. ncbi Characterization of mammalian synemin, an intermediate filament protein present in all four classes of muscle cells and some neuroglial cells: co-localization and interaction with type III intermediate filament proteins and keratins
    Yoshiaki Hirako
    Unit of Biosystems, Graduate School of Human Informatics, Nagoya University, Nagoya, Japan
    Cell Tissue Res 313:195-207. 2003
    ..a monoclonal antibody, we have detected a high molecular weight muscle protein, co-localized and co-isolating with desmin. Searching a human cDNA database with partial amino acid sequences of the protein, we found a cDNA clone encoding ..
  32. ncbi Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene
    M C Dalakas
    Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1382, USA
    N Engl J Med 342:770-80. 2000
    Myofibrillar myopathies, often referred to as desmin-related myopathies, are a heterogeneous group of inherited or sporadic distal-onset skeletal myopathies associated with cardiomyopathy...
  33. pmc A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization
    Manolis Mavroidis
    Cell Biology Division, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    FASEB J 22:3318-27. 2008
    A missense mutation (Ile 451 to Met) at the tail domain of the muscle-specific intermediate filament protein desmin has been suggested to be a genetic cause of dilated cardiomyopathy...
  34. pmc Characterization of kinin receptors modulating neurogenic contractions of the mouse isolated vas deferens
    J Maas
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Brazil
    Br J Pharmacol 114:1471-7. 1995
    ....
  35. ncbi UDP-glucose: flavonol 7-O-glucosyltransferase activity in flower extracts of Chrysanthemum segetum
    K Stich
    TU Wien, , Technische Mikroskopie und Organische Rohstofflehre, Vienna, Austria
    Z Naturforsch C 52:153-8. 1997
    ..1 mu kat/kg protein) as substrate, indicating that hydroxylation of quercetin in 8-position to gossypetin precedes 7-O-glucosylation...
  36. doi Mutations in desmin's carboxy-terminal "tail" domain severely modify filament and network mechanics
    Harald Bär
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Mol Biol 397:1188-98. 2010
    Inherited mutations in the gene coding for the intermediate filament protein desmin have been demonstrated to cause severe skeletal and cardiac myopathies...
  37. pmc Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin
    H Li
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Cell Biol 124:827-41. 1994
    The muscle-specific intermediate filament protein, desmin, is one of the earliest myogenic markers whose functional role during myogenic commitment and differentiation is unknown...
  38. ncbi Molecular characteristics and interactions of the intermediate filament protein synemin. Interactions with alpha-actinin may anchor synemin-containing heterofilaments
    R M Bellin
    Muscle Biology Group, Department of Biochemistry, Iowa State University, Ames, Iowa 50011 3260, USA
    J Biol Chem 274:29493-9. 1999
    ..filament (IF)-associated protein because of its colocalization and copurification with the IF proteins desmin and vimentin in muscle cells...
  39. ncbi Desmin: molecular interactions and putative functions of the muscle intermediate filament protein
    M L Costa
    Laboratório de Diferenciação Muscular e Citoesqueleto, Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Braz J Med Biol Res 37:1819-30. 2004
    b>Desmin is the intermediate filament (IF) protein occurring exclusively in muscle and endothelial cells...
  40. pmc Bradykinin B1 receptors in the rabbit urinary bladder: induction of responses, smooth muscle contraction, and phosphatidylinositol hydrolysis
    S K Butt
    Biomedical Sciences Division, King s College London, Chelsea
    Br J Pharmacol 114:612-7. 1995
    ..We demonstrate, for the first time, B1 receptor-coupling to phosphatidylinositol hydrolysis in an intact tissue preparation...
  41. ncbi Desmin: a major intermediate filament protein essential for the structural integrity and function of muscle
    Denise Paulin
    Biologie Moleculaire de la Differenciation, Universite Paris, 75251 Paris, France
    Exp Cell Res 301:1-7. 2004
    b>Desmin is a muscle-specific protein and a key subunit of the intermediate filament in cardiac, skeletal and smooth muscles...
  42. ncbi Lower active force generation and improved fatigue resistance in skeletal muscle from desmin deficient mice
    J Balogh
    Department of Physiological Sciences, Lund University, BMC F11, Tornavagen 10, SE 221 84, Lund, Sweden
    J Muscle Res Cell Motil 24:453-9. 2003
    The mechanical effects of the intermediate filament protein desmin was examined in desmin deficient mice (Des-/-) and their wild type control (Des+/+)...
  43. pmc Desmin mediates TNF-alpha-induced aggregate formation and intercalated disk reorganization in heart failure
    Panagiota Panagopoulou
    Cell Biology Division, Center of Basic Research, and 2Cardiovascular Research Division, Center of Clinical Research, Biomedical Research Foundation, Academy of Athens, Athens 11527, Greece
    J Cell Biol 181:761-75. 2008
    We explored the involvement of the muscle-specific intermediate filament protein desmin in the model of tumor necrosis factor alpha (TNF-alpha)-induced cardiomyopathy...
  44. ncbi Assembly properties of two CNBr fragments of avian desmin that correspond to the headpiece domain and helix 1B
    T Saeed
    Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Ohio 45267 0521
    Biochem Biophys Res Commun 165:1059-66. 1989
    To study how different domains of the muscle-specific intermediate filament protein, desmin, contribute to its polymerization, two of its CNBr fragments were examined as to their oligomeric structure under assembly conditions...
  45. ncbi Interaction of [D-Trp6, Des-Gly10] LHRH ethylamide and hydroxy propyl beta-cyclodextrin (HPbetaCD): thermodynamics of interaction and protection from degradation by alpha-chymotrypsin
    K N Koushik
    Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198-6025, USA
    Pharm Dev Technol 6:595-606. 2001
    ..This inclusion, providing steric hindrance, may be one of the mechanisms by which HPbetaCD reduces enzymatic hydrolysis of deslorelin...
  46. ncbi Life-long effect of a single neonatal treatment with estradiol or progesterone on rat uterine estrogen receptor binding capacity
    G Csaba
    Department of Biology, Semmelweis University of Medicine, Budapest, Hungary
    Horm Metab Res 24:167-71. 1992
    ....
  47. ncbi [Role of B1 receptors in the endothelial protective effect of ischaemic preconditioning]
    J F Bouchard
    , , , Canada
    Arch Mal Coeur Vaiss 91:941-5. 1998
    ..B2 receptors do not play any role in that protection...
  48. ncbi Inhibition of the angiotensin converting enzyme by perindoprilat and release of nitric oxide
    B Desta
    Center for Experimental Therapeutics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Hypertens 8:1S-6S. 1995
    ..In addition, the response to perindoprilat may be due to factors other than just protection of bound bradykinin from degradation...
  49. pmc Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro
    A Dray
    Sandoz Institute for Medical Research, London
    Br J Pharmacol 107:1129-34. 1992
    ..The effects of bradykinin were mediated by a B2 receptor...
  50. pmc Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1 beta in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 production
    J P Galizzi
    Cerep, Celle l evescault, France
    Br J Pharmacol 113:389-94. 1994
    ..This observation suggests that IL-1 but not LPS, in addition to increase in the number of receptors, signals the cell to permit the coupling of B1 receptors to the PLA2/cyclo-oxygenase pathway...
  51. pmc Mediation by B1 and B2 receptors of vasodepressor responses to intravenously administered kinins in anaesthetized dogs
    N Nakhostine
    Department of Physiology, Faculty of Medicine, , , Canada
    Br J Pharmacol 110:71-6. 1993
    ..These findings provide pharmacological evidence for the existence of functionally active B1 receptors in canine cardiovascular homeostasis...
  52. ncbi Atriopeptin regulation and renal function in conscious spontaneously hypertensive rats
    J P Koepke
    Searle Research and Development, Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110
    Am J Hypertens 3:622-7. 1990
    ..Compared to vehicle control rats, plasma APir was increased during coadministration of SC-46542 and thiorphan in both SHR (998 +/- 76 v 5.10 +/- 116 pg/mL) and WKY (775 +/- 36 v 414 +/- 36 pg/mL).(ABSTRACT TRUNCATED AT 250 WORDS)..
  53. ncbi The effect of oxidation or alkylation on the separation of wool keratin proteins by two-dimensional gel electrophoresis
    Jeffrey E Plowman
    Wool Research Organisation of New Zealand, Christchurch, New Zealand
    Proteomics 3:942-50. 2003
    ..Peroxide treatment was found to have only a minor effect on the 2-DE separation of the intermediate filament protein (IFP) class...
  54. ncbi [Belgian law on the Régime de l'alcool of 1919: from the individual measures to social well-being]
    R Campos
    Departamento de Historia de la Ciencia, , CSIC
    Cuad Complut Hist Med Cienc 2:275-94. 1993
    ....
  55. ncbi Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes
    J E Klaunig
    Department of Pathology, Medical College of Ohio, Toledo 43699, USA
    Toxicol Pathol 12:119-25. 1984
    ....
  56. ncbi [Mediastinitis after sternotomy. Mortality and hospital length of stay. Groupe parisien détude des sternotomies]
    J C Lucet
    , , Paris
    Arch Mal Coeur Vaiss 90:471-5. 1997
    ..The authors conclude that deep wound infection after sternotomy is responsible for almost doubling the duration of hospital stay. The economic consequences alone justify active research into the prevention of this complication...
  57. pmc Bradykinin receptors in mouse and rat isolated superior cervical ganglia
    G R Seabrook
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex
    Br J Pharmacol 115:368-72. 1995
    ..Furthermore the depolarizations caused by B1 and B2 agonists in this tissue can be increased following exposure to interleukin l beta, and by blocking peptide degradation with captopril...
  58. pmc Structural heterogeneity of the Fe(2+)-N epsilon (HisF8) bond in various hemoglobin and myoglobin derivatives probed by the Raman-active iron histidine stretching mode
    H Gilch
    Institute of Experimental Physics, University of Bremen, Germany
    Biophys J 65:1470-85. 1993
    ..Quaternary and tertiary transitions of the protein alter the population of these substates thus giving rise to a redistribution of the VFe-HiS sublines which shifts the corresponding peak frequency to higher values...
  59. pmc Polymorphous ventricular tachycardia following cardiopulmonary bypass
    L D Thompson
    Cardiothoracic Surgery Service, Valley Children Hospital, Fresno, California 93726, USA
    J Natl Med Assoc 88:49-51. 1996
    ..This case shows the effectiveness of intravenous magnesium in controlling Torsade des pointes in postoperative coronary bypass patients...
  60. pmc Pharmacological characterization of bradykinin receptors in canine cultured tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung College of Medicine and Technology, Tao Yuan, Taiwan
    Br J Pharmacol 114:67-72. 1995
    ..7 It is concluded that the pharmacological characteristics of the bradykinin receptors in canine cultured TSMCs are primarily of the B2 receptor subtype...
  61. ncbi Identification of two N-terminal non-alpha-helical domain motifs important in the assembly of glial fibrillary acidic protein
    J E Ralton
    Department of Biochemistry, The University, Dundee, UK
    J Cell Sci 107:1935-48. 1994
    ..GFAP is the only type III intermediate filament protein in which this motif is not readily identified...
  62. ncbi [Evidence for a glomerular receptor for bradykinin in rats. Effect of sodium intake on density and affinity of the receptor]
    J L Bascands
    INSERM U 133, , Toulouse
    Arch Mal Coeur Vaiss 82:1219-22. 1989
    ..45 +/- 1.3 and 13.25 +/- 1.17 fmol/mg protein).(ABSTRACT TRUNCATED AT 250 WORDS)..
  63. ncbi [The Musée du service de santé des armeés in Val-de-Grâce]
    J J Ferrandis

    Hist Sci Med 33:183-90. 1999
    ..The visitor may also discover the marvelous mortars and pharmacy pots collection of the doctors Debat...
  64. pmc The role of bradykinin B1 receptors in the maintenance of intra-articular plasma extravasation in chronic antigen-induced arthritis
    S C Cruwys
    Inflammation Group, London Hospital Medical College
    Br J Pharmacol 113:940-4. 1994
    ..The data presented in this study suggest an evolving role for B1 receptors in the mediation of plasma extravasation in inflamed joint tissues. A role for BK antagonists in the treatment of arthritis is also suggested...
  65. ncbi Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 mice
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:325-33. 1999
    ..The data show that cell cycle kinetics, in addition to changes in morphology, are altered in the developing mouse uterus following neonatal exposure to DES...
  66. pmc Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505
    F Pons
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 109:234-42. 1993
    ..However, they question the role of PAF receptors on platelets in this model. The results also indicate that PAF may be involved in platelet accumulation induced by zymosan in rabbit skin...
  67. ncbi Connexin 43 expression in glial cells of developing rhombomeres of Xenopus laevis
    Bharti Katbamna
    Department of Speech Pathology and Audiology, Western Michigan University, Kalamazoo, MI 49008 5355, USA
    Int J Dev Neurosci 22:47-55. 2004
    ..Xenopus rhombomeres and then tracked expression of connexin 43 and glial fibrillary acidic protein, an intermediate filament protein known to mark glia during rhombomeric development...
  68. pmc Regulation of vimentin intermediate filaments in endothelial cells by hypoxia
    Tiegang Liu
    Pulmonary and Critical Care Division, Department of Medicine Tupper Research Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Physiol Cell Physiol 299:C363-73. 2010
    ..We now show that vimentin, a major intermediate filament protein in endothelial cells, is regulated by hypoxia...
  69. ncbi The IAEA/WHO TL dosimetry service for radiotherapy centres 1969-87
    H Svensson
    International Atomic Energy Agency, Vienna, Austria
    Acta Oncol 29:461-7. 1990
    ..7%. About 5% of the centres had deviations larger than 30%, at least on one occasion. It is shown that the accuracy in dosimetry improves considerably for those departments participating more than once in the TL dosimetry service...
  70. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
    ....
  71. ncbi Lens membrane fraction associated intermediate filaments of different aged rats
    Charles Ricky Fleschner
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
    Curr Eye Res 24:296-304. 2002
    ..To describe the intermediate filament proteins vimentin, filensin and phakinin associated with different fractions isolated from neonatal, 10 day old and 20 day old rat lenses...
  72. pmc Vasopressin-stimulated [3H]-inositol phosphate and [3H]-phosphatidylbutanol accumulation in A10 vascular smooth muscle cells
    R Plevin
    Department of Biochemistry, University of Glasgow
    Br J Pharmacol 107:109-15. 1992
    ....
  73. ncbi Lysosomal enzymes in pregnant and steroid treated rats
    A Isaksson
    Department of Clinical Chemistry, University Hospital, Lund, Sweden
    Horm Metab Res 20:274-7. 1988
    ..No significant changes were observed for the other two enzymes. Thus, steroid treatment did not fully reproduce the enzyme changes seen in pregnancy, which may indicate that these are not solely due to a hormone effect...
  74. ncbi A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein
    Y Chan
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Genes Dev 8:2574-87. 1994
    ....
  75. ncbi Modified adipokinetic peptides containing two tryptophan residues and their activities in vitro and in vivo in Locusta
    M J Lee
    Department of Biology, Birkbeck College, University of London, London, UK
    J Comp Physiol B 166:61-7. 1996
    ..The different responses exploited in these assays may be exerted through different receptor populations...
  76. pmc Vasoconstrictor effects of various neuropeptide Y analogues on the rat tail artery in the presence of phenylephrine
    M Tschopl
    Laboratoire de Pharmacologie Cellulaire et Moleculaire, C N R S URA 600, Universite Louis Pasteur Strasbourg, Illkirch, France
    Br J Pharmacol 110:1098-104. 1993
    ..The effects of [des-Ser3,Lys4]D-Cys2-NPY indicate that the Y1-receptor may possess an allosteric binding site...
  77. ncbi Expression and distribution of cytokeratins and vimentin in rat larynx and trachea following irradiation
    S Bartel-Friedrich
    Department of Otorhinolaryngology, Phoniatrics and Pedaudiology Section, University Hospital, Martin Luther University Halle Wittenberg, Germany
    Anticancer Res 27:2059-69. 2007
    ..However, reports on radiogenic intermediate filament protein alterations in laryngeal-tracheal tissues are very rare...
  78. pmc Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse
    C R Correa
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianopolis SC, Brazil
    Br J Pharmacol 110:193-8. 1993
    ..In addition, the current results also demonstrate that the inflammatory oedema associated with the later phase of formalin-induced pain seems to be mediated by endogenous BK, via activation of B2 receptors...
  79. ncbi Hemodynamic effects of atrial natriuretic factor clearance receptor occupancy in conscious sheep
    D G Parkes
    Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Australia
    Am J Hypertens 3:829-32. 1990
    ..These studies support the concept of the metabolism of ANF via clearance receptors, suggesting that long-term hemodynamic actions of endogenous ANF may be achieved via prolonged blockade of these clearance receptors...
  80. ncbi Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:237-45. 2000
    ....
  81. pmc [Serodiagnosis of toxoplasmosis: a comparative multicenter study of a standard scale through various actual tests and expression of the results in international units. Groupe de travail toxoplasmose du Contrôle national de qualité en parasotologie. Synd
    J C Petithory
    Service de Biologie, , Centre Hospitalier, Gonesse, France
    Bull World Health Organ 74:291-8. 1996
    ..It is therefore essential that the conditions and limits for a positive reaction be carefully defined in each case, especially for commercially available kits...
  82. ncbi Differential expressions of protein kinase C isozymes during proliferation and differentiation of human skeletal muscle cells in vitro
    J Boczan
    Department of Physiology and Cell Physiology, University Medical School of Debrecen, Hungary
    Acta Neuropathol 99:96-104. 2000
    ..The expressions of desmin, used as a muscle-specific intermediate filament protein marker of differentiation, and of different PKC isozymes were detected by single and double ..
  83. ncbi Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiation
    A Sandilands
    Department of Biochemistry, The University, Dundee, UK
    J Cell Sci 108:1397-406. 1995
    The cells of the eye lens contain the type III intermediate filament protein vimentin, as well as two other intermediate filament proteins, CP49 and filensin. These two proteins appear to be unique to the differentiated lens fibre cell...
  84. ncbi [The Hypertension Cochrane Review Group. Presentation and user's guide]
    F Gueyffier
    , Service de Pharmacologie Clinique, Lyon
    Arch Mal Coeur Vaiss 90:1159-63. 1997
    ..The second edition in 1996 of the Cochrane Library included 114 systematic reviews and 131 protocols, being the only media with similar objectives...
  85. ncbi [The war victim]
    P Hugeux
    , , Clamart
    Bull Acad Natl Med 178:1357-63; discussion 1363-4. 1994
    ..These joint actions, added to the ones of very influential autonomous associations, contribute to give handicapped war victims an honourable citizenship...
  86. pmc Bradykinin-stimulated phosphoinositide metabolism in cultured canine tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 111:21-8. 1994
    ..The transduction mechanism of BK coupled to PI hydrolysis is sensitive to feedback regulation by PKC...
  87. pmc Mechanisms of bradykinin-induced contraction of the guinea-pig gallbladder in vitro
    D A Cabrini
    Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 114:1549-56. 1995
    ....
  88. pmc Type II intermediate-filament proteins from wool. The amino acid sequence of component 5 and comparison with component 7c
    L G Sparrow
    C S I R O Division of Wool Technology, Parkville, Vic, Australia
    Biochem J 282:291-7. 1992
    ....
  89. ncbi Modulation of ANF-R2/ANP-C receptors by angiotensin II in vascular smooth muscle cells
    A Palaparti
    Department of Physiology, , , Canada
    Am J Hypertens 9:930-4. 1996
    ..This uncoupling may be associated with the phosphorylation of the Gi protein by PKC activated by AII...
  90. ncbi The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413
    Olaf Bossinger
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, D 40225 Duesseldorf, Germany
    Dev Biol 268:448-56. 2004
    ..We demonstrate that: (i) the widely used monoclonal antibody MH33 reacts (only) with the gut-specific intermediate filament protein encoded by the ifb-2 gene; (ii) IFB-2 protein accumulates near the gut lumen beginning at the lima ..
  91. ncbi Simultaneous expression of keratin and glial fibrillary acidic protein by the same cells in epiretinal membranes
    S A Vinores
    Department of Ophthalmology and Neuroscience, Johns Hopkins University Hospital, Baltimore, Maryland
    Invest Ophthalmol Vis Sci 33:3361-6. 1992
    ..Examination of intermediate filament protein content by immunocytochemical analysis can help to identify some cells with altered ultrastructure but ..
  92. ncbi A new marker for cup cells in the rabbit small intestine: expression of vimentin intermediate filament protein
    Y Fujimura
    Division of Gastroenterology, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    Med Electron Microsc 34:223-9. 2001
    ..In rabbit small intestine, vimentin is useful for the detection of cup cells, as well as M cells, and may facilitate the investigation of these little understood cells...
  93. ncbi Novel cell lines derived from adult human ventricular cardiomyocytes
    Mercy M Davidson
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Mol Cell Cardiol 39:133-47. 2005
    ..heavy chain, alpha-cardiac actin, troponin I, desmoplakin, alpha actinin, the muscle-specific intermediate filament protein, desmin, the cardiomyocyte-specific peptide hormones, BNP, the L-type calcium channel alpha1C subunit ..
  94. ncbi In vitro assembly properties of mutant and chimeric intermediate filament proteins: insight into the function of sequences in the rod and end domains of IF
    Lisa Gu
    Molecular and Cell Biology Graduate Program, University of Maryland Biotechnology Institute, Baltimore 21201, USA
    Exp Cell Res 298:249-61. 2004
    ..either mutated or swapped between a cytoplasmic (mouse neurofilament-light (NF-L) subunit) and nuclear intermediate filament protein (human lamin A)...
  95. ncbi Effects of homologous and heterologous neuraminidase vaccines in chickens against H5N1 highly pathogenic avian influenza
    Y J Lee
    Avian Disease Division, National Veterinary Research and Quarantine Service, Ministry of Agriculture and Forestry, 480 Anyang 6 dong, Anyang, Gyeonggi do 430 016, Korea
    Avian Dis 51:476-8. 2007
    ..The low pathogenic avian influenza A/wild bird feces/CSM2/02 (H5N3) virus was used as a heterologous neuraminidase vaccine, and HPAI A/CK/Korea/ES/03 (H5N1) virus was used ..
  96. doi Concussion in professional football: morphology of brain injuries in the NFL concussion model--part 16
    Anders Hamberger
    Institute of Biomedicine, Section of Anatomy and Cell Biology, University of Goteborg, Goteborg, Sweden
    Neurosurgery 64:1174-82; discussion 1182. 2009
    ..4 to 11.2 m/s with a 50-g impactor. The impact causes a 6% to 28% incidence of meningeal hemorrhages and 0.1- to 0.3-mm focal petechiae depending on the impact velocity. This study addresses the immunohistochemical responses of the brain...
  97. ncbi [Not Available]
    R Van Tiggelen
    , Bruxelles, Belgique
    Hist Sci Med 29:29-36. 1995
    ..He was the Honorary President of the Third Congress of Radiology in the French-speaking world. He was due to receive an international tribute, but an unfortunate date had been chosen: May 19, 1940...
  98. pmc Vascular mode of action of kinin B1 receptors and development of a cellular model for the investigation of these receptors
    L Levesque
    , , Canada
    Br J Pharmacol 109:1254-62. 1993
    ..PGI2 is not involved in the mechanical response, possible because the rabbit aorta is refractory to this prostaglandin...
  99. ncbi Uridine phosphorylase association with vimentin. Intracellular distribution and localization
    R L Russell
    Department of Internal Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 276:13302-7. 2001
    Uridine phosphorylase (UPase), a key enzyme in the pyrimidine salvage pathway, is associated with the intermediate filament protein vimentin, in NIH 3T3 fibroblasts and colon 26 cells...
  100. ncbi Xefiltin, a new low molecular weight neuronal intermediate filament protein of Xenopus laevis, shares sequence features with goldfish gefiltin and mammalian alpha-internexin and differs in expression from XNIF and NF-L
    Y Zhao
    Department of Biological Sciences, University at Albany, State University of New York 12222, USA
    J Comp Neurol 377:351-64. 1997
    ..Thus, we speculate that the persistence of alpha-internexin-like nIF proteins in the amphibian nervous system may be important for its continued potential for growth and plasticity...
  101. pmc Effect of bradykinin and prostaglandins on the release of calcitonin gene-related peptide-like immunoreactivity from the rat spinal cord in vitro
    L Andreeva
    Sandoz Institute for Medical Research, London
    Br J Pharmacol 108:185-90. 1993
    ..Whether this action of bradykinin has any physiological function in nociceptive transmission remains unclear....

Research Grants73

  1. Intermediate filament cytoskeleton and cell shape in Caulobacter crescentus
    Christine Jacobs Wagner; Fiscal Year: 2006
    ..This study of crescentin, a bacterial version of an intermediate filament protein, is likely to provide insight into the way its human counterparts assemble and function within cells...
  2. Intermediate filament cytoskeleton and cell shape in Caulobacter crescentus
    Christine Jacobs Wagner; Fiscal Year: 2007
    ..This study of crescentin, a bacterial version of an intermediate filament protein, is likely to provide insight into the way its human counterparts assemble and function within cells...
  3. Intermediate filament cytoskeleton and cell shape in Caulobacter crescentus
    Christine Jacobs Wagner; Fiscal Year: 2009
    ..This study of crescentin, a bacterial version of an intermediate filament protein, is likely to provide insight into the way its human counterparts assemble and function within cells...
  4. Skeletal Muscle Injury: Mechanism Prevention & Treatment
    Richard Lieber; Fiscal Year: 2007
    ..3) to measure the relative strengthening ability of normal muscles compared to muscles devoid of the intermediate filament protein desmin...
  5. Role of Vimentin, sPLA2 and LysoPC in Autoimmune Disease
    SUZANNE BARBOUR; Fiscal Year: 2005
    ..The "receptor" for this pool of sPLA2 is the rod domain of vimentin, an intermediate filament protein that is exposed when cells undergo apoptosis...
  6. BIOCHEMISTRY OF THE NEURONAL CYTOSKELTON
    RONALD LIEM; Fiscal Year: 2002
    ..builds on observations made during the current grant period that the over-expression of the neuronal intermediate filament protein alpha-internexin causes the formation of axonal swellings in transgenic mice, as well as observations ..
  7. Primaquine-binding proteins identified in Pneumocystis
    SHERRY QUEENER; Fiscal Year: 2006
    ..Preliminary identification of one of these proteins suggests it is an intermediate filament protein, which may relate to the profound cytoplasmic disruption produced in Pneumocystis by 8-aminoquinolines...
  8. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL FULTS; Fiscal Year: 2007
    ..The nestin gene encodes an intermediate filament protein expressed by neural progenitor cells prior to their commitment to neuronal or glial differentiation...
  9. GENETIC ANALYSIS OF ERBB2 IN MAMMALIAN DEVELOPMENT
    Kuo Fen Lee; Fiscal Year: 2010
    ..Furthermore, recently results suggest that Cdk5 and its target substrate intermediate filament protein nestin both of which are co-localized at synaptic sites, are the downstream molecules of the NRG1-erbB ..
  10. GENETIC ANALYSIS OF ERBB2 IN MAMMALIAN DEVELOPMENT
    Kuo Fen Lee; Fiscal Year: 2010
    ..Furthermore, recently results suggest that Cdk5 and its target substrate intermediate filament protein nestin both of which are co-localized at synaptic sites, are the downstream molecules of the NRG1-erbB ..
  11. Phenotypic Plasticity in Human Neuroblastoma
    Robert Ross; Fiscal Year: 2007
    ..N-myc, in turn, regulates nestin and this neuroectodermal intermediate filament protein appears to mediate several of the oncogenic function of N-myc...
  12. THE HORMONAL CONTROL OF FETAL GROWTH
    AUGUSTINE D ERCOLE; Fiscal Year: 2004
    ..The IGF-I Tg mice also exhibit an increase in the number of neurons that immunostain for nestin, an intermediate filament protein expressed by neural stem cells and their progeny...