desmin

The desmin gene encodes an intermediate filament protein that is present in skeletal, cardiac, and smooth muscle cells...

b>Desmin-related myofibrillar myopathy (DRM) is a cardiac and skeletal muscle disease caused by mutations in the desmin (DES) gene...

..in human alphaB crystallin that selectively interacted with native or partially unfolded filament proteins desmin, glial-fibrillary acidic protein, and actin...

b>Desmin-related myopathy (OMIM 601419) is a familial disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias and restrictive heart failure, and by intracytoplasmic accumulation of desmin-..

Several desmin mutations have been described over the past few years in patients with dilated and restrictive cardiomyopathy, often in association with distal myopathy...

The intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein are cleaved in vitro by human immunodeficiency virus type 1 protease (HIV-1 PR)...

..The aim of this study was thus to develop such a novel networking approach based on the relevance concept, which is ideal to reveal integrative effects of multiple genes in the underlying genetic circuit for complex diseases...

..We report the first characterization of a muscle-cell-specific LCR, which is linked to the human desmin gene (DES)...

..The balance between intermediate filament protein phosphorylation by Rho kinase and dephosphorylation by type 1 protein phosphatase may affect the ..

..myofibrils treated in vitro with human immunodeficiency virus type 1 protease showed that myosin heavy chain, desmin, tropomyosin, and a fraction of the actin were all cleaved...

Mice lacking desmin produce muscle fibers with Z disks and normal sarcomeric organization. However, the muscles are mechanically fragile and degenerate upon repeated contractions...

b>Desmin is a muscle-specific intermediate filament that is encoded by a gene assigned to human chromosome 2q35. Desmin-related myopathies are inherited disorders characterized by an intrasarcoplasmic accumulation of desmin...

..skeletal and cardiac muscles have demonstrated that synemin localises at the Z-band, where it associates with desmin and alpha-actinin...

..A possible causal relationship is suggested between these B2 receptor-mediated membrane potential-dependent, and -independent events,and their roles in excitation contraction coupling...

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..Taken together, these findings suggest that glucagon, through the activation of unidentified receptors located on ZF/R cells, inhibits adenylate cyclase, thereby dampening glucocorticoid response to ACTH...

..The stimulation of B2-bradykinin receptors induces the activation of the cyclo-oxygenase pathway, leading either to contraction or relaxation depending on the tone of the trachea...

..So far, this will be the first report of repellent activity of estrogenic compounds toward trivial fungal zoospores...

..Such mechanisms may be relevant for the manifestation of acute and chronic inflammatory processes...

..The present results might provide an experimental basis for clinical investigations of the effects of icatibant in infectious diseases where the release of collagenases from bacteria causes rapid spreading of inflammation...

..Further research is needed to investigate different schedules of chemotherapy and hormones, or to test the possibility of combining various mitogens...

..8. These results suggest that oestradiol pretreatment had a modulating effect on cholinergic responses.The addition of oestrogen to the tissue environment enhances this inhibitory effect...

..Synemin is a desmin-associated type VI intermediate filament protein. Neither its impact on desmin network nor how it integrates into desmin filament is yet elucidated...

Myofibrillar myopathies, often referred to as desmin-related myopathies, are a heterogeneous group of inherited or sporadic distal-onset skeletal myopathies associated with cardiomyopathy...

A missense mutation (Ile 451 to Met) at the tail domain of the muscle-specific intermediate filament protein desmin has been suggested to be a genetic cause of dilated cardiomyopathy...

..a monoclonal antibody, we have detected a high molecular weight muscle protein, co-localized and co-isolating with desmin. Searching a human cDNA database with partial amino acid sequences of the protein, we found a cDNA clone encoding ..

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..1 mu kat/kg protein) as substrate, indicating that hydroxylation of quercetin in 8-position to gossypetin precedes 7-O-glucosylation...

Inherited mutations in the gene coding for the intermediate filament protein desmin have been demonstrated to cause severe skeletal and cardiac myopathies...

..filament (IF)-associated protein because of its colocalization and copurification with the IF proteins desmin and vimentin in muscle cells...

b>Desmin is the intermediate filament (IF) protein occurring exclusively in muscle and endothelial cells...

The muscle-specific intermediate filament protein, desmin, is one of the earliest myogenic markers whose functional role during myogenic commitment and differentiation is unknown...

..We demonstrate, for the first time, B1 receptor-coupling to phosphatidylinositol hydrolysis in an intact tissue preparation...

Mutations in the intermediate filament protein desmin cause a distinct class of myofibrillar myopathies that are characterized by deposition of aggregated desmin...

b>Desmin is a muscle-specific protein and a key subunit of the intermediate filament in cardiac, skeletal and smooth muscles...

The mechanical effects of the intermediate filament protein desmin was examined in desmin deficient mice (Des-/-) and their wild type control (Des+/+)...

To study how different domains of the muscle-specific intermediate filament protein, desmin, contribute to its polymerization, two of its CNBr fragments were examined as to their oligomeric structure under assembly conditions...

We explored the involvement of the muscle-specific intermediate filament protein desmin in the model of tumor necrosis factor alpha (TNF-alpha)-induced cardiomyopathy...

..This inclusion, providing steric hindrance, may be one of the mechanisms by which HPbetaCD reduces enzymatic hydrolysis of deslorelin...

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..B2 receptors do not play any role in that protection...

..In addition, the response to perindoprilat may be due to factors other than just protection of bound bradykinin from degradation...

..The effects of bradykinin were mediated by a B2 receptor...

..This observation suggests that IL-1 but not LPS, in addition to increase in the number of receptors, signals the cell to permit the coupling of B1 receptors to the PLA2/cyclo-oxygenase pathway...

..Compared to vehicle control rats, plasma APir was increased during coadministration of SC-46542 and thiorphan in both SHR (998 +/- 76 v 5.10 +/- 116 pg/mL) and WKY (775 +/- 36 v 414 +/- 36 pg/mL).(ABSTRACT TRUNCATED AT 250 WORDS)..

..These findings provide pharmacological evidence for the existence of functionally active B1 receptors in canine cardiovascular homeostasis...

..Peroxide treatment was found to have only a minor effect on the 2-DE separation of the intermediate filament protein (IFP) class...

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..The authors conclude that deep wound infection after sternotomy is responsible for almost doubling the duration of hospital stay. The economic consequences alone justify active research into the prevention of this complication...

..Furthermore the depolarizations caused by B1 and B2 agonists in this tissue can be increased following exposure to interleukin l beta, and by blocking peptide degradation with captopril...

..Quaternary and tertiary transitions of the protein alter the population of these substates thus giving rise to a redistribution of the VFe-HiS sublines which shifts the corresponding peak frequency to higher values...

..This case shows the effectiveness of intravenous magnesium in controlling Torsade des pointes in postoperative coronary bypass patients...

..GFAP is the only type III intermediate filament protein in which this motif is not readily identified...

..7 It is concluded that the pharmacological characteristics of the bradykinin receptors in canine cultured TSMCs are primarily of the B2 receptor subtype...

..45 +/- 1.3 and 13.25 +/- 1.17 fmol/mg protein).(ABSTRACT TRUNCATED AT 250 WORDS)..

..The visitor may also discover the marvelous mortars and pharmacy pots collection of the doctors Debat...

..The data show that cell cycle kinetics, in addition to changes in morphology, are altered in the developing mouse uterus following neonatal exposure to DES...

..The data presented in this study suggest an evolving role for B1 receptors in the mediation of plasma extravasation in inflamed joint tissues. A role for BK antagonists in the treatment of arthritis is also suggested...

..However, they question the role of PAF receptors on platelets in this model. The results also indicate that PAF may be involved in platelet accumulation induced by zymosan in rabbit skin...

..Xenopus rhombomeres and then tracked expression of connexin 43 and glial fibrillary acidic protein, an intermediate filament protein known to mark glia during rhombomeric development...

..We now show that vimentin, a major intermediate filament protein in endothelial cells, is regulated by hypoxia...

..7%. About 5% of the centres had deviations larger than 30%, at least on one occasion. It is shown that the accuracy in dosimetry improves considerably for those departments participating more than once in the TL dosimetry service...

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..To describe the intermediate filament proteins vimentin, filensin and phakinin associated with different fractions isolated from neonatal, 10 day old and 20 day old rat lenses...

..No significant changes were observed for the other two enzymes. Thus, steroid treatment did not fully reproduce the enzyme changes seen in pregnancy, which may indicate that these are not solely due to a hormone effect...

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..The different responses exploited in these assays may be exerted through different receptor populations...

..In addition, the current results also demonstrate that the inflammatory oedema associated with the later phase of formalin-induced pain seems to be mediated by endogenous BK, via activation of B2 receptors...

..However, reports on radiogenic intermediate filament protein alterations in laryngeal-tracheal tissues are very rare...

..The effects of [des-Ser3,Lys4]D-Cys2-NPY indicate that the Y1-receptor may possess an allosteric binding site...

..These studies support the concept of the metabolism of ANF via clearance receptors, suggesting that long-term hemodynamic actions of endogenous ANF may be achieved via prolonged blockade of these clearance receptors...

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..The expressions of desmin, used as a muscle-specific intermediate filament protein marker of differentiation, and of different PKC isozymes were detected by single and double ..

..It is therefore essential that the conditions and limits for a positive reaction be carefully defined in each case, especially for commercially available kits...

The cells of the eye lens contain the type III intermediate filament protein vimentin, as well as two other intermediate filament proteins, CP49 and filensin. These two proteins appear to be unique to the differentiated lens fibre cell...

..These joint actions, added to the ones of very influential autonomous associations, contribute to give handicapped war victims an honourable citizenship...

..The second edition in 1996 of the Cochrane Library included 114 systematic reviews and 131 protocols, being the only media with similar objectives...

..The transduction mechanism of BK coupled to PI hydrolysis is sensitive to feedback regulation by PKC...

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..This uncoupling may be associated with the phosphorylation of the Gi protein by PKC activated by AII...

..Examination of intermediate filament protein content by immunocytochemical analysis can help to identify some cells with altered ultrastructure but ..

..We demonstrate that: (i) the widely used monoclonal antibody MH33 reacts (only) with the gut-specific intermediate filament protein encoded by the ifb-2 gene; (ii) IFB-2 protein accumulates near the gut lumen beginning at the lima ..

..In rabbit small intestine, vimentin is useful for the detection of cup cells, as well as M cells, and may facilitate the investigation of these little understood cells...

..either mutated or swapped between a cytoplasmic (mouse neurofilament-light (NF-L) subunit) and nuclear intermediate filament protein (human lamin A)...

..heavy chain, alpha-cardiac actin, troponin I, desmoplakin, alpha actinin, the muscle-specific intermediate filament protein, desmin, the cardiomyocyte-specific peptide hormones, BNP, the L-type calcium channel alpha1C subunit ..

..4 to 11.2 m/s with a 50-g impactor. The impact causes a 6% to 28% incidence of meningeal hemorrhages and 0.1- to 0.3-mm focal petechiae depending on the impact velocity. This study addresses the immunohistochemical responses of the brain...

..The low pathogenic avian influenza A/wild bird feces/CSM2/02 (H5N3) virus was used as a heterologous neuraminidase vaccine, and HPAI A/CK/Korea/ES/03 (H5N1) virus was used ..

..He was the Honorary President of the Third Congress of Radiology in the French-speaking world. He was due to receive an international tribute, but an unfortunate date had been chosen: May 19, 1940...

Uridine phosphorylase (UPase), a key enzyme in the pyrimidine salvage pathway, is associated with the intermediate filament protein vimentin, in NIH 3T3 fibroblasts and colon 26 cells...

..Thus, we speculate that the persistence of alpha-internexin-like nIF proteins in the amphibian nervous system may be important for its continued potential for growth and plasticity...

..PGI2 is not involved in the mechanical response, possible because the rabbit aorta is refractory to this prostaglandin...

..Whether this action of bradykinin has any physiological function in nociceptive transmission remains unclear....

..Since ANP receptor density and affinity are influenced by various physiological and pathological conditions, clinical and diagnostic applications seem possible...

..In order to be totally convincing, the study of the future of operated patients requires analysis of many different factors...

..The converse replacement of Gly at position 14 by Asp in human CGRP enhanced this analogue activity. Among the synthetic analogues, des-1-Ala-des-alpha-amino chicken CGRP, exhibited the most potent and long lasting biological activity...

..Peaks in the chromatograms obtained were generally symmetrical. At a pH of the mobile phase as high as 11.2, the stationary phase was still stable after more than 160 h of exposure...

..The procedure outlined here can be employed for the clinical production of [123I]SCH 23982 as a SPECT radiopharmaceutical, as well as [125I]SCH 23982 to be used for in vitro receptor-binding applications...

..Two copper-sensitive mutants with significant reduction in copper resistance were identified: CSM1, a mutant disrupted in trpA gene (tryptophan synthase alpha subunit), and CSM2, a mutant disrupted in clpA gene (..

..This study of crescentin, a bacterial version of an intermediate filament protein, is likely to provide insight into the way its human counterparts assemble and function within cells...

..This study of crescentin, a bacterial version of an intermediate filament protein, is likely to provide insight into the way its human counterparts assemble and function within cells...

..This study of crescentin, a bacterial version of an intermediate filament protein, is likely to provide insight into the way its human counterparts assemble and function within cells...

..3) to measure the relative strengthening ability of normal muscles compared to muscles devoid of the intermediate filament protein desmin...

..The "receptor" for this pool of sPLA2 is the rod domain of vimentin, an intermediate filament protein that is exposed when cells undergo apoptosis...

..builds on observations made during the current grant period that the over-expression of the neuronal intermediate filament protein alpha-internexin causes the formation of axonal swellings in transgenic mice, as well as observations ..

..Preliminary identification of one of these proteins suggests it is an intermediate filament protein, which may relate to the profound cytoplasmic disruption produced in Pneumocystis by 8-aminoquinolines...

..The nestin gene encodes an intermediate filament protein expressed by neural progenitor cells prior to their commitment to neuronal or glial differentiation...

..Furthermore, recently results suggest that Cdk5 and its target substrate intermediate filament protein nestin both of which are co-localized at synaptic sites, are the downstream molecules of the NRG1-erbB ..

..Furthermore, recently results suggest that Cdk5 and its target substrate intermediate filament protein nestin both of which are co-localized at synaptic sites, are the downstream molecules of the NRG1-erbB ..

..N-myc, in turn, regulates nestin and this neuroectodermal intermediate filament protein appears to mediate several of the oncogenic function of N-myc...

..The IGF-I Tg mice also exhibit an increase in the number of neurons that immunostain for nestin, an intermediate filament protein expressed by neural stem cells and their progeny...