DEFB119

Summary

Gene Symbol: DEFB119
Description: defensin beta 119
Alias: DEFB-19, DEFB-20, DEFB120, DEFB20, ESC42-RELA, ESC42-RELB, beta-defensin 119, defensin, beta 120, defensin, beta 19, defensin, beta 20
Species: human

Top Publications

  1. doi Production and characterization of recombinant human beta-defensin DEFB120
    Haiyan Liu
    The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China School of Life Science and Technology, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009, China
    J Pept Sci 20:251-7. 2014
  2. ncbi Human beta-defensins
    M Pazgier
    Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cell Mol Life Sci 63:1294-313. 2006
  3. ncbi Current status of defensins and their role in innate and adaptive immunity
    Periathamby Antony Raj
    Division of Periodontics, School of Dentistry, Marquette University, Milwaukee, WI 53201 1881, USA
    FEMS Microbiol Lett 206:9-18. 2002
  4. ncbi Defensins of vertebrate animals
    Robert I Lehrer
    Department of Medicine Room CHS 37 062, and Molecular Biology Institute University of California at Los Angeles UCLA Center for the Health Sciences, Los Angeles, CA 90095, USA
    Curr Opin Immunol 14:96-102. 2002
  5. ncbi Testis-specific expression of a novel mouse defensin-like gene, Tdl
    Miwako Yamamoto
    Graduate School of Medicine, Osaka University, Japan
    Mech Dev 116:217-21. 2002
  6. pmc Identification, characterization, and evolution of a primate beta-defensin gene cluster
    Y Radhakrishnan
    Department of Pediatrics, Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, NC 27599 7500, USA
    Genes Immun 6:203-10. 2005

Research Grants

  1. STRUCTURE/FUNCTIONS OF HUMAN TEAR LIPOPHILIN
    Robert Lehrer; Fiscal Year: 2001
  2. ALTRUINS, NATURAL ANTIBIOTICS OF THE MALE GENITAL TRACT
    Robert Lehrer; Fiscal Year: 2001
  3. DEFENSINS--ANTIMICROBIAL PEPTIDES OF HUMAN NEUTROPHILS
    Robert Lehrer; Fiscal Year: 2002
  4. ALPHA HELICAL CATHELICIDINS AND HOST DEFENSE
    Robert Lehrer; Fiscal Year: 2003
  5. Biacore 3000 SPR Instrument
    Robert Lehrer; Fiscal Year: 2004
  6. Theta-defensins Novel HIV-1 Uptake Inhibitors
    Robert Lehrer; Fiscal Year: 2007
  7. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
  8. Retrocyclins: Cyclic mini-defensins that inactivate anthrax toxins
    ROBERT IRVING contact LEHRER; Fiscal Year: 2010

Scientific Experts

  • ROBERT IRVING contact LEHRER
  • Haiyan Liu
  • M Pazgier
  • Y Radhakrishnan
  • Donghai Lin
  • Aijie Xin
  • Miwako Yamamoto
  • Periathamby Antony Raj
  • Yihua Gu
  • Heguo Yu
  • Huijuan Shi
  • Hua Diao
  • Yonglian Zhang
  • W Lu
  • D Yang
  • J Lubkowski
  • D M Hoover
  • K G Hamil
  • S L Young
  • S Yenugu
  • S H Hall
  • F S French
  • Andrew R Dentino
  • Yasuhisa Matsui

Detail Information

Publications6

  1. doi Production and characterization of recombinant human beta-defensin DEFB120
    Haiyan Liu
    The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China School of Life Science and Technology, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009, China
    J Pept Sci 20:251-7. 2014
    ..In the present work, we successfully expressed and purified a novel human beta-defensin, DEFB120, using the IMPACT-TWIN system in Escherichia coli and identified the purified homogeneous proteins using MALDI-..
  2. ncbi Human beta-defensins
    M Pazgier
    Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cell Mol Life Sci 63:1294-313. 2006
    ..In this review, we present some recent advances in the studies of human beta-defensins, with an emphasis on possible correlations between their structural and functional properties...
  3. ncbi Current status of defensins and their role in innate and adaptive immunity
    Periathamby Antony Raj
    Division of Periodontics, School of Dentistry, Marquette University, Milwaukee, WI 53201 1881, USA
    FEMS Microbiol Lett 206:9-18. 2002
    ....
  4. ncbi Defensins of vertebrate animals
    Robert I Lehrer
    Department of Medicine Room CHS 37 062, and Molecular Biology Institute University of California at Los Angeles UCLA Center for the Health Sciences, Los Angeles, CA 90095, USA
    Curr Opin Immunol 14:96-102. 2002
    ..There is now convincing evidence that defensins augment adaptive immune responses...
  5. ncbi Testis-specific expression of a novel mouse defensin-like gene, Tdl
    Miwako Yamamoto
    Graduate School of Medicine, Osaka University, Japan
    Mech Dev 116:217-21. 2002
    ..5dpc when the sexual differentiation of gonads is initiated. Tdl is specifically expressed in gonads among adult tissues, and its expression persisted in Sertoli cells...
  6. pmc Identification, characterization, and evolution of a primate beta-defensin gene cluster
    Y Radhakrishnan
    Department of Pediatrics, Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, NC 27599 7500, USA
    Genes Immun 6:203-10. 2005
    ..Here we report the characterization of DEFB119-DEFB123, five genes in the human beta-defensin cluster locus on chromosome 20q11.1...

Research Grants8

  1. STRUCTURE/FUNCTIONS OF HUMAN TEAR LIPOPHILIN
    Robert Lehrer; Fiscal Year: 2001
    ..The long-term objectives for this research are to learn how lipophilin contributes to corneal and conjuctival health, and to explore its potential for creating new diagnostic and therapeutic modalities. ..
  2. ALTRUINS, NATURAL ANTIBIOTICS OF THE MALE GENITAL TRACT
    Robert Lehrer; Fiscal Year: 2001
    ..S. are sexually transmitted. According to CDC estimates, STDs other than AIDS add 10 billion dollars to the nation's annual health care I costs. The proposed studies could lead to novel approaches for STD prophylaxis. ..
  3. DEFENSINS--ANTIMICROBIAL PEPTIDES OF HUMAN NEUTROPHILS
    Robert Lehrer; Fiscal Year: 2002
    ..The work with murine neutrophils, whose content of endogenous antimicrobial polypeptides differs greatly from those of humans, will provide essential information relevant to the interpretation of murine models of human infection. ..
  4. ALPHA HELICAL CATHELICIDINS AND HOST DEFENSE
    Robert Lehrer; Fiscal Year: 2003
    ..The experiments will expand our knowledge about these important peptides, and should provide the information needed to develop them as antibiotics for topical bronchopulmonary use in cystic fibrosis. ..
  5. Biacore 3000 SPR Instrument
    Robert Lehrer; Fiscal Year: 2004
    ..These include the development of new agents and approaches to prevent and treat infections caused by HIV-1 and other viral pathogens, and fundamental issues related to cell targeting and survival. ..
  6. Theta-defensins Novel HIV-1 Uptake Inhibitors
    Robert Lehrer; Fiscal Year: 2007
    ..Specific Aim 2 will be realized by a combination of microchemical techniques, including surface plasmon resonance, tandem mass spectrometry, and state-of-the-art lectinomic and peptidomic chemistry. ..
  7. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  8. Retrocyclins: Cyclic mini-defensins that inactivate anthrax toxins
    ROBERT IRVING contact LEHRER; Fiscal Year: 2010
    ..anthracis spores in mouse models as per the revised Specific Aims. All remaining Aims can be addressed in a two-year time period. PHS ..