DECR1

Summary

Gene Symbol: DECR1
Description: 2,4-dienoyl-CoA reductase 1
Alias: DECR, NADPH, SDR18C1, 2,4-dienoyl-CoA reductase, mitochondrial, 2,4-dienoyl-CoA reductase 1, mitochondrial, 4-enoyl-CoA reductase, short chain dehydrogenase/reductase family 18C member 1
Species: human
Products:     DECR1

Top Publications

  1. Tebay L, Robertson H, Durant S, Vitale S, Penning T, Dinkova Kostova A, et al. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med. 2015;88:108-146 pubmed publisher
    ..Nrf2 also controls genes involved in intermediary metabolism, positively regulating those involved in NADPH generation, purine biosynthesis, and the β-oxidation of fatty acids, while suppressing those involved in ..
  2. Sil R, Ray D, Chakraborti A. Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in experimental rat model. Mol Cell Biochem. 2015;409:177-89 pubmed publisher
    ..glycation end products, reactive oxygen species, lipid peroxidation, protein carbonyl, protein kinase Cα, NADPH oxidase-2, and decreased glutathione cycle components established liver damage and oxidative stress in fructose-..
  3. Li C, Li L, Yang C, Zhong Y, Wu D, Shi L, et al. Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4/ROS-MAPK pathway. Biochem Biophys Res Commun. 2017;493:277-285 pubmed publisher
    ..The mechanisms were investigated by detecting levels of NADPH Oxidase 4 (NOX4),p22phox, cytochrome P4502E1 (CYP2E1),Bax,B-cell lymphoma 2 (Bcl-2),cleaved-caspase 3 and 9 and ..
  4. Cai H, Su S, Li Y, Zeng H, Zhu Z, Guo J, et al. Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF-?/Smad signaling pathways. J Ethnopharmacol. 2018;212:153-165 pubmed publisher
    ..prevent epithelial-mesenchymal transition (EMT) of human renal tubular epithelial (HK-2) cell by inhibiting NADPH oxidase/ROS/ERK and TGF-?/Smad signaling pathways...
  5. Jian W, Yu S, Tang M, Duan H, Huang J. A combination of the main constituents of Fufang Xueshuantong Capsules shows protective effects against streptozotocin-induced retinal lesions in rats. J Ethnopharmacol. 2016;182:50-6 pubmed publisher
    ..to measure the activity of aldose reductase (AR) by measuring the nicotinamide adenine dinucleotide phosphate (NADPH) consumption at 340nm...
  6. Smallwood M, Nissim A, Knight A, Whiteman M, Haigh R, Winyard P. Oxidative stress in autoimmune rheumatic diseases. Free Radic Biol Med. 2018;125:3-14 pubmed publisher
    ..The sources of such reactive species include NADPH oxidases (NOXs), the mitochondrial electron transport chain, nitric oxide synthases, nitrite reductases, and the ..
  7. Ye S, Lowther S, Stambas J. Inhibition of reactive oxygen species production ameliorates inflammation induced by influenza A viruses via upregulation of SOCS1 and SOCS3. J Virol. 2015;89:2672-83 pubmed publisher
    ..Proinflammatory stimuli are known to induce intracellular reactive oxygen species by activating NADPH oxidase activity...
  8. Seara F, Barbosa R, de Oliveira D, Gran da Silva D, Carvalho A, Freitas Ferreira A, et al. Administration of anabolic steroid during adolescence induces long-term cardiac hypertrophy and increases susceptibility to ischemia/reperfusion injury in adult Wistar rats. J Steroid Biochem Mol Biol. 2017;171:34-42 pubmed publisher
    ..1 and SURa) was analyzed by qRT-PCR and Western Blot. NADPH oxidase (Nox)-related reactive oxygen species generation was assessed by spectrofluorimetry...
  9. Schmidt P, Escobar A, Torres J, Martinez C, Rizzetti D, Kunz S, et al. Aluminum exposure for one hour decreases vascular reactivity in conductance and resistance arteries in rats. Toxicol Appl Pharmacol. 2016;313:109-118 pubmed publisher
    ..endothelium, the nitric oxide synthase inhibitor l-NAME, the potassium channel blocker tetraethylammonium, and the NADPH oxidase inhibitor apocynin were performed in segments from aortic and mesenteric resistance arteries...

More Information

Publications157 found, 100 shown here

  1. Gallorini M, Petzel C, Bolay C, Hiller K, Cataldi A, Buchalla W, et al. Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability. Biomaterials. 2015;56:114-28 pubmed publisher
    ..enzymatic antioxidants (catalase, peroxiredoxin, thioredoxin 1, thioredoxin reductase, heme oxygenase-1) and the NADPH-regenerating system (glucose 6-phosphate dehydrogenase, transaldolase) was increased...
  2. Kaur T, Borse V, Sheth S, Sheehan K, Ghosh S, Tupal S, et al. Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea. J Neurosci. 2016;36:3962-77 pubmed publisher
    ..produces ototoxicity that is mediated in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase pathway in the cochlea...
  3. Kanbur M, Siliğ Y, Eraslan G, Karabacak M, Soyer Sarıca Z, Şahin S. The toxic effect of cypermethrin, amitraz and combinations of cypermethrin-amitraz in rats. Environ Sci Pollut Res Int. 2016;23:5232-42 pubmed publisher
    ..and testis) and hepatic drug-metabolising (cytochrome P450 2E1 (CYP2E1), NADH-cytochrome b5 reductase (CYPb5), NADPH-cytochrome c reductase/NADPH cytocrome P450 reductase (CYTC), glutathione S-transferase (GST), glutathione (GSH)) ..
  4. Rawat A, Bhattad S, Singh S. Chronic Granulomatous Disease. Indian J Pediatr. 2016;83:345-53 pubmed publisher
    ..It is caused by mutations in genes encoding protein subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex...
  5. Lee J, Kang M, Wang H, Naik G, Mobley J, Sonpavde G, et al. Endostatin inhibits androgen-independent prostate cancer growth by suppressing nuclear receptor-mediated oxidative stress. FASEB J. 2017;31:1608-1619 pubmed publisher
    ..oxygen species (ROS) scavenging machinery, including catalase, glutathione synthetase, glutathione reductase, NADPH-cytochrome P450 reductase, biliverdin reductase, and thioredoxin reductase, resulting in a concomitant reduction ..
  6. Paslawska U, Kiczak L, Bania J, Paslawski R, Janiszewski A, Dzięgiel P, et al. Inducible NO synthase is constitutively expressed in porcine myocardium and its level decreases along with tachycardia-induced heart failure. Cardiovasc Pathol. 2016;25:3-11 pubmed publisher
    ..The aconitase activity (based on measurement of the concomitant formation of NADPH from NADP(+)), a marker of oxidative stress, was analyzed in mitochondrial and cytosolic LV fractions...
  7. Marchi K, Ceron C, Muniz J, De Martinis B, Tanus Santos J, Tirapelli C. NADPH Oxidase Plays a Role on Ethanol-Induced Hypertension and Reactive Oxygen Species Generation in the Vasculature. Alcohol Alcohol. 2016;51:522-34 pubmed publisher
    Investigate the role of NADPH oxidase on ethanol-induced hypertension and vascular oxidative stress. Male Wistar rats were treated with ethanol (20% v/v). Apocynin (10 mg/kg/day, i.p.) prevented ethanol-induced hypertension...
  8. Bellaver B, Souza D, Souza D, Quincozes Santos A. Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain. Mol Neurobiol. 2017;54:2969-2985 pubmed publisher
    ..showed an increase in oxidative/nitrosative stress with mitochondrial dysfunction, an increase in RNA oxidation, NADPH oxidase (NOX) activity, superoxide levels, and inducible nitric oxide synthase (iNOS) expression levels...
  9. McCarty M. NADPH Oxidase Activity in Cerebral Arterioles Is a Key Mediator of Cerebral Small Vessel Disease-Implications for Prevention. Healthcare (Basel). 2015;3:233-51 pubmed publisher
    ..Rodent studies strongly suggest that activation of Nox2-dependent NADPH oxidase activity is a crucial driver of these structural and functional derangements of cerebral arterioles, in ..
  10. Bouabout G, Ayme Dietrich E, Jacob H, Champy M, Birling M, Pavlovic G, et al. Nox4 genetic inhibition in experimental hypertension and metabolic syndrome. Arch Cardiovasc Dis. 2018;111:41-52 pubmed publisher
    ..Nox4 is a hydrogen peroxide nicotinamide adenine dinucleotide phosphate (NADPH) oxidase isoform - found in various cardiovascular cells and tissues, but also in tissues such as the liver - ..
  11. Spadoni T, Svegliati Baroni S, Amico D, Albani L, Moroncini G, Avvedimento E, et al. A reactive oxygen species-mediated loop maintains increased expression of NADPH oxidases 2 and 4 in skin fibroblasts from patients with systemic sclerosis. Arthritis Rheumatol. 2015;67:1611-22 pubmed publisher
    ..oxygen species (ROS) contribute to the pathogenesis of fibrosis in systemic sclerosis (SSc; scleroderma), and NADPH oxidase (NOX) is an important source of ROS...
  12. Lou Z, Wang A, Duan X, Hu G, Song G, Zuo M, et al. Upregulation of NOX2 and NOX4 Mediated by TGF-? Signaling Pathway Exacerbates Cerebral Ischemia/Reperfusion Oxidative Stress Injury. Cell Physiol Biochem. 2018;46:2103-2113 pubmed publisher
    Ischemic stroke is still one of the leading debilitating diseases with high morbidity and mortality. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) play an important role in cerebral ischemia/reperfusion (I/R) injury...
  13. Tang X, Zan X, Zhao L, Chen H, Chen Y, Chen W, et al. Proteomics analysis of high lipid-producing strain Mucor circinelloides WJ11: an explanation for the mechanism of lipid accumulation at the proteomic level. Microb Cell Fact. 2016;15:35 pubmed publisher
    ..which participate in the pentose phosphate pathway, were up-regulated, leading to the increased production of NADPH, the reducing power for fatty acid biosynthesis...
  14. Spanaki C, Kotzamani D, Plaitakis A. Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions. Neurochem Res. 2017;42:92-107 pubmed publisher
    ..oxidative deamination of glutamate to ?-ketoglutarate and ammonia while reducing NAD+ and/or NADP+ to NADH and/or NADPH. It links amino acid with carbohydrate metabolism, contributing to Krebs cycle anaplerosis, energy production, ..
  15. Kiersztan A, Trojan N, Tempes A, Nalepa P, Sitek J, Winiarska K, et al. DHEA supplementation to dexamethasone-treated rabbits alleviates oxidative stress in kidney-cortex and attenuates albuminuria. J Steroid Biochem Mol Biol. 2017;174:17-26 pubmed publisher
    ..Treatment with DHEA markedly reduced dexP-induced oxidative stress in kidney-cortex due to a decline in NADPH oxidase activity and enhancement of catalase activity...
  16. Mehdad A, Campos N, Arruda S, Siqueira E. Iron Deprivation May Enhance Insulin Receptor and Glut4 Transcription in Skeletal Muscle of Adult Rats. J Nutr Health Aging. 2015;19:846-54 pubmed publisher
    ..by either dietary iron restriction or iron supplementation was accessed by measuring malondialdehyde, carbonyl, NADPH oxidase, glutathione peroxidase, glutathione reductase and glutathione-s-transferase in various tissues...
  17. Varga Z, Giricz Z, Liaudet L, Hasko G, Ferdinandy P, Pacher P. Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. Biochim Biophys Acta. 2015;1852:232-42 pubmed publisher
    ..of free fatty acids, and leptin have been implicated in increased generation of superoxide anion by mitochondria, NADPH oxidases and xanthine oxidoreductase in diabetic vasculature and myocardium...
  18. Pérez S, Taléns Visconti R, Rius Pérez S, Finamor I, Sastre J. Redox signaling in the gastrointestinal tract. Free Radic Biol Med. 2017;104:75-103 pubmed publisher
    ..in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch signaling pathways mainly through NADPH oxidases (NOXs)...
  19. Cai H, Su S, Qian D, Guo S, Tao W, Cong X, et al. Renal protective effect and action mechanism of Huangkui capsule and its main five flavonoids. J Ethnopharmacol. 2017;206:152-159 pubmed publisher
    ..of α-smooth muscle actin (α-SMA), phosphorylation-extracellular signal-regulated kinase (p-ERK1/2), NADPH Oxidase 1, NADPH Oxidase 2 and NADPH Oxidase 4 in adenine-induced CRF rats...
  20. Ambrożewicz E, Wojcik P, Wroński A, Łuczaj W, Jastrząb A, Zarkovic N, et al. Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients. Cells. 2018;7: pubmed publisher
    ..results obtained revealed enhanced activity of pro-oxidant enzymes nicotinamide adenine dinucleotide phosphate (NADPH) and xanthine oxidases in granulocytes with a decrease of enzymatic and non-enzymatic antioxidants in the plasma ..
  21. Liu Y, Li L, Fu J, Kao K, Huang C, Chien Y, et al. Induced pluripotent stem cell therapy ameliorates hyperoxia-augmented ventilator-induced lung injury through suppressing the Src pathway. PLoS ONE. 2014;9:e109953 pubmed publisher
    ..plasminogen activator inhibitor-1 (PAI-1) production, Src activation, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, and malaldehyde (MDA) level...
  22. Triplett J, Zhang Z, Sultana R, Cai J, Klein J, Büeler H, et al. Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease. J Neurochem. 2015;133:750-65 pubmed publisher
    ..dehydrogenase; ALDOA, aldolase A; APT1, acyl-protein thioesterase 1; CaM, calmodulin; CBR3, carbonyl reductase [NADPH] 3; ENO2, gamma-enolase; HPRT, hypoxanthine-guanine phosphoribosyltransferase; HSP70, heat-shock-related 70 kDa ..
  23. Vizziano Cantonnet D, Lasalle A, Di Landro S, Klopp C, Genthon C. De novo transcriptome analysis to search for sex-differentiation genes in the Siberian sturgeon. Gen Comp Endocrinol. 2018;: pubmed publisher
    ..type XXVIII alpha 1 chain and collagen type II alpha 1 chain, matrix metalloproteinases 24-1 and 24-2, and NADPH oxidase organizer 1, which, along with the somatic cells, provide architectural support for the stem-cell niche; ..
  24. Al Maghrebi M, Renno W. Altered expression profile of glycolytic enzymes during testicular ischemia reperfusion injury is associated with the p53/TIGAR pathway: effect of fructose 1,6-diphosphate. Peerj. 2016;4:e2195 pubmed publisher
    ..ATP and NADPH depletion was also induced by tIRI and was accompanied by an increased Malondialdehyde concentration, reduced ..
  25. He Y, Zhou L, Fan Z, Liu S, Fang W. Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N?acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress. Cell Death Dis. 2018;9:568 pubmed publisher
    ..No effects were noted by addition of apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, and NADPH oxidase 4 (NOX 4) and NOX 2 expressions were not altered, indicating that PA-induced ..
  26. Smith K, Rajgor D, Hanley J. Differential regulation of the Rac1 GTPase-activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons. J Biol Chem. 2017;292:20173-20183 pubmed publisher
    ..Rac1 activity caused by OGD/ischemia contributes to neuronal death in hippocampal neurons via diverse effects on NADPH oxidase activity and dendritic spine morphology...
  27. Illeperuma R, Kim D, Park Y, Son H, Kim J, Kim J, et al. Areca nut exposure increases secretion of tumor-promoting cytokines in gingival fibroblasts that trigger DNA damage in oral keratinocytes. Int J Cancer. 2015;137:2545-57 pubmed publisher
    ..Generation of reactive oxygen species (ROS) and DNA damage response, triggered by cytokines, were abolished when NADPH oxidase (NOX) 1 and 4 were silenced in IHOK, indicating that cytokine-triggered DNA damage was caused by ROS ..
  28. Li R, Klockenbusch C, Lin L, Jiang H, Lin S, Kast J. Quantitative Protein Sulfenic Acid Analysis Identifies Platelet Releasate-Induced Activation of Integrin β2 on Monocytes via NADPH Oxidase. J Proteome Res. 2016;15:4221-4233 pubmed
    ..The activation of LFA-1 was mediated by ROS from NADPH oxidase (NOX) activation...
  29. Kim T, Flick R, Brunzelle J, Singer A, Evdokimova E, Brown G, et al. Novel Aldo-Keto Reductases for the Biocatalytic Conversion of 3-Hydroxybutanal to 1,3-Butanediol: Structural and Biochemical Studies. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..Both AKRs used NADPH as a cofactor, reduced a broad range of aldehydes, and showed low activities toward acetaldehyde...
  30. Yao P, Sun H, Xu C, Chen T, Zou B, Jiang P, et al. Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions. J Biol Chem. 2017;292:17113-17120 pubmed publisher
    ..u>pathway (PPP), malic enzyme (ME), and folate metabolism are the three major routes for generating cellular NADPH, a key cofactor involved in redox control and reductive biosynthesis...
  31. Zhang X, Zhang S, Ding Y, Feng Y, Zhu H, Huang L, et al. Association between ADSL, GARS-AIRS-GART, DGAT1, and DECR1 expression levels and pork meat quality traits. Genet Mol Res. 2015;14:14823-30 pubmed publisher
    ..The association between expression of four genes (ADSL, GARS-AIRS-GART, DGAT1, and DECR1) and meat quality traits was also investigated...
  32. Giordana L, Sosa M, Leroux A, Mendoza E, Petray P, Nowicki C. Molecular and functional characterization of two malic enzymes from Leishmania parasites. Mol Biochem Parasitol. 2018;219:67-76 pubmed publisher
    ..Since these pathogens require large amounts of NADPH to maintain intracellular redox homeostasis, oxidoreductases that catalyze the production of NADPH are considered ..
  33. Meng Y, Pan M, Zheng B, Chen Y, Li W, Yang Q, et al. Autophagy attenuates angiotensin II-induced pulmonary fibrosis by inhibiting redox imbalance-mediated NLRP3 inflammasome activation. Antioxid Redox Signal. 2018;: pubmed publisher
    ..vitro</i>, AngII promoted intercellular ROS, H<sub>2</sub>O<sub>2</sub> and NADPH oxidase 4 (NOX4) protein levels and reduced the GSH concentration, thereby leading to NLRP3 inflammasome ..
  34. Zhao C, Wang X, Wang X, Wu K, Li P, Chang N, et al. Glucose-6-phosphate dehydrogenase and alternative oxidase are involved in the cross tolerance of highland barley to salt stress and UV-B radiation. J Plant Physiol. 2015;181:83-95 pubmed publisher
    ..The inhibition of AP or G6PDH activity resulted in a significant accumulation or reduction of NADPH content, respectively, under UV-B+NaCl treatment in highland barley leaves...
  35. Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt M, Samonis G, Drakos E, et al. Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity. Cell Host Microbe. 2016;19:79-90 pubmed publisher
    ..Mechanistically, Aspergillus melanin inhibits NADPH oxidase-dependent activation of LAP by excluding the p22phox subunit from the phagosome...
  36. Belsare K, Horn T, Ruff A, Martinez R, Magnusson A, Holtmann D, et al. Directed evolution of P450cin for mediated electron transfer. Protein Eng Des Sel. 2017;30:119-127 pubmed publisher
    ..low total turnover numbers, enzyme instability, low product yields and the requirement of the expensive co-factor NADPH. Bioelectrocatalysis is an alternative to replace NADPH in cell-free P450-catalyzed reactions...
  37. Wu Q, Yao B, Li N, Ma L, Deng Y, Yang Y, et al. Nrf2 mediates redox adaptation in NOX4-overexpressed non-small cell lung cancer cells. Exp Cell Res. 2017;352:245-254 pubmed publisher
    ..Our previous studies have confirmed that NADPH oxidase 4 (NOX4) is abundantly expressed in non-small cell lung cancer (NSCLC) and confers apoptosis resistance on ..
  38. Štambergová H, Zemanová L, Lundová T, Malčeková B, Skarka A, Šafr M, et al. Human DHRS7, promising enzyme in metabolism of steroids and retinoids?. J Steroid Biochem Mol Biol. 2016;155:112-9 pubmed publisher
    ..to be an integral membrane protein of the endoplasmic reticulum facing the lumen which has shown at least in vitro NADPH-dependent reducing activity toward several eobiotics and xenobiotics bearing a carbonyl moiety...
  39. Walker M, Hoier B, Walker P, Schulze K, Bangsbo J, Hellsten Y, et al. Vasoactive enzymes and blood flow responses to passive and active exercise in peripheral arterial disease. Atherosclerosis. 2016;246:98-105 pubmed publisher
    ..measured with Doppler ultrasound and muscle protein levels of phosphorylated endothelial nitric oxide synthase, NADPH oxidase, cyclooxygenase 1 and 2, thromboxane synthase, and prostacyclin synthase were determined...
  40. May J. Ascorbic acid repletion: A possible therapy for diabetic macular edema?. Free Radic Biol Med. 2016;94:47-54 pubmed publisher
    ..activates multiple pathways, some of which lead to increased oxidative stress, such as those involving NF-ĸB, NADPH oxidase, and endothelial nitric oxide synthase...
  41. Latham Birt S, Purcell R, Botham K, Wheeler Jones C. Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway. J Lipid Res. 2016;57:1204-18 pubmed publisher
    ..Mechanistically, HO-1 induction by all CRLPs requires NADPH oxidase 4, with PUFA-containing particles additionally dependent upon mitochondrial reactive oxygen species...
  42. Vimercati S, Büchi M, Zielinski J, Peduto N, Mevissen M. Testosterone metabolism of equine single CYPs of the 3A subfamily compared to the human CYP3A4. Toxicol In Vitro. 2017;41:83-91 pubmed publisher
    ..In this study, three equine isoenzymes of the 3A subfamily, the equine flavoprotein NADPH-P450 oxidoreductase (POR), and the cytochrome b5 (CYB5) were cloned, sequenced and heterologously expressed in a ..
  43. Bagaitkar J, Barbu E, Perez Zapata L, Austin A, Huang G, Pallat S, et al. PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo. J Leukoc Biol. 2017;101:449-457 pubmed publisher
    Mutations in the leukocyte NADPH oxidase that abrogate superoxide production result in chronic granulomatous disease (CGD), an inherited immunodeficiency associated with recurrent infections and inflammatory complications...
  44. Sandbichler A, Jansen B, Peer B, Paulitsch M, Pelster B, Egg M. Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells. Cell Physiol Biochem. 2018;46:1159-1174 pubmed publisher
    ..to the alignment of three major cellular redox systems, namely the circadian oscillations of NAD+/NADH and NADP+/NADPH ratios and of increased nocturnal levels of oxidized peroxiredoxins, resulting in a highly oxidized nocturnal ..
  45. Zhu X, Li X, Zhao Y, Ji X, Wang Y, Fu Y, et al. Effects of Senegenin against hypoxia/reoxygenation-induced injury in PC12 cells. Chin J Integr Med. 2016;22:353-61 pubmed publisher
    ..Cleaved caspase-3 and activity of NADPH oxidase (NOX) were determined by colorimetric protease assay and enzyme linked immunosorbent assay, respectively...
  46. Morel F, Rousset F, Vu Chuong Nguyen M, Trocme C, Grange L, Lardy B. [NADPH oxidase Nox4, a putative therapeutic target in osteoarthritis]. Bull Acad Natl Med. 2015;199:673-86; discussion 686-7 pubmed
    The NADPH oxidases, Nox, are transmembrane hemoproteins, whose exclusive function is to reduce molecular oxygen to produce superoxide anion O2°- and consequently highly reactive oxidant and toxic oxygen species, ROS...
  47. Choi H, Ettinger N, Rohrbough J, Dikalova A, Nguyen H, Lamb F. LRRC8A channels support TNF?-induced superoxide production by Nox1 which is required for receptor endocytosis. Free Radic Biol Med. 2016;101:413-423 pubmed publisher
    ..VRAC via type 1 TNF? receptors (TNFR1), and this requires superoxide (O2•-) production by NADPH oxidase 1 (Nox1). VRAC inhibitors suppress the inflammatory response to TNF? by an unknown mechanism...
  48. Nucci L, Santos S, Brunialti M, Sharma N, Machado F, Assunção M, et al. Expression of genes belonging to the interacting TLR cascades, NADPH-oxidase and mitochondrial oxidative phosphorylation in septic patients. PLoS ONE. 2017;12:e0172024 pubmed publisher
    ..Our data show changes in the expression of genes belonging to the interacting TLR cascades, NADPH-oxidase and oxidative phosphorylation...
  49. Chan P, Wang Y, Chen Y, Hsu W, Tian Y, Hsieh P. Importance of NADPH oxidase-mediated redox signaling in the detrimental effect of CRP on pancreatic insulin secretion. Free Radic Biol Med. 2017;112:200-211 pubmed publisher
    ..CRP increased NADPH oxidase-mediated ROS (reactive oxygen species) production, which simultaneously promoted the production of ..
  50. Partow S, Hyland P, Mahadevan R. Synthetic rescue couples NADPH generation to metabolite overproduction in Saccharomyces cerevisiae. Metab Eng. 2017;43:64-70 pubmed publisher
    ..cerevisiae using a novel approach based on synthetic rescue. Here, we first perturb the cytosolic NADPH metabolism via deletion of glucose-6-phosphate dehydrogenase (ZWF1)...
  51. Yang J, Lee I, Lu F, Chung C, Lee M, Cheng Y, et al. Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-?B Pathway. J Immunol Res. 2017;2017:9489383 pubmed publisher
    ..PG inhibited the TMZ-induced reactive oxygen species (ROS) generation. The mitochondrial complex III and NADPH oxidase are two critical sites that can be considered to regulate antimigration in TMZ-treated U87MG cells...
  52. Hou Y, Li S, Wu M, Wei J, Ren Y, Du C, et al. Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy. Am J Physiol Renal Physiol. 2016;310:F547-59 pubmed publisher
    ..TGF)-β1, Nox4, and thioredoxin-interacting protein (TXNIP), as well as activation of p38 MAPK and CREB and NADPH oxidase activity in diabetic kidneys...
  53. Zhang X, Cao X, Zhang C, Zhao Z. 17β-estradiol protects against doxorubicin-induced cardiotoxicity in male Sprague-Dawley rats by regulating NADPH oxidase and apoptosis genes. Mol Med Rep. 2017;15:2695-2702 pubmed publisher
    ..These results demonstrate that E2 treatment may protect the heart against DOX-induced cardiotoxicity in male rats potentially through the regulation of NOX2, NOX4 and apoptosis genes. ..
  54. Gavillet M, Martinod K, Renella R, Wagner D, Williams D. A key role for Rac and Pak signaling in Neutrophil Extracellular Traps (NETs) formation defines a new potential therapeutic target. Am J Hematol. 2017;: pubmed publisher
    NET formation in mice (NETosis) is supported by reactive oxygen species (ROS) production by NADPH oxidase and histone hypercitrullination by peptidylarginine deiminase 4 (PAD4)...
  55. Choi S, Kim J, Li H, Lee S, Seok Y, Kim T, et al. Altered redox state modulates endothelial KCa2.3 and KCa3.1 levels in normal pregnancy and preeclampsia. Antioxid Redox Signal. 2018;: pubmed publisher
    ..ox-LDL, progesterone or soluble fms-like tyrosine kinase-1 (sFlt-1) elevated superoxide levels via elevating NADPH oxidase 2 (NOX2) and NOX4 levels and reducing SOD1 levels, thereby downregulating KCas...
  56. Xu Q, Kulkarni A, Sajith A, Hussein D, Brown D, Guner O, et al. Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4. Bioorg Med Chem. 2018;26:989-998 pubmed publisher
    b>NADPH oxidases (Nox enzymes) are critical mediators of both physiologic and pathophysiologic processes. Nox enzymes catalyze NADPH-dependent generation of reactive oxygen species (ROS), including superoxide and hydrogen peroxide...
  57. Lee W, Liu S, Chiang C, Lin S, Liang K, Chen C, et al. Aryl Hydrocarbon Receptor Deficiency Attenuates Oxidative Stress-Related Mesangial Cell Activation and Macrophage Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy. Antioxid Redox Signal. 2016;24:217-231 pubmed
    ..of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2), lipid peroxidation, oxidative stress, NADPH oxidase activity, and N-É›-carboxymethyllysine (CML, a major advanced glycation end product) in STZ-induced ..
  58. Kim H, Yoo H, Jang J, Lin H, Seo E, Zhang Y, et al. Wall stretch and thromboxane Aâ‚‚ activate NO synthase (eNOS) in pulmonary arterial smooth muscle cells via Hâ‚‚Oâ‚‚ and Akt-dependent phosphorylation. Pflugers Arch. 2016;468:705-16 pubmed publisher
    ..1-10 μM) effectively increased the sensitivity to TXA2/L-NAME (105 % of 80K). Vice versa, NADPH oxidase inhibitors, reactive oxygen species scavengers, or an Akt inhibitor (SC-66) suppressed TXA2/L-NAME-induced ..
  59. Pucciariello C, Perata P. New insights into reactive oxygen species and nitric oxide signalling under low oxygen in plants. Plant Cell Environ. 2017;40:473-482 pubmed publisher
    ..This originates at various subcellular sites. The activation of NADPH oxidase(s), in complex with other proteins, is responsible for ROS production at the plasma membrane...
  60. Liu Z, Lv Y, Zhang Y, Liu F, Zhu L, Pan S, et al. Matrine-Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species-Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling. J Am Heart Assoc. 2017;6: pubmed publisher
    ..species production, cell apoptosis, phosphorylation of MKKs/p38 MAPK, and expression levels of heme oxygenase/NADPH quinone oxidoreductase were assessed...
  61. Saez F, Hong N, Garvin J. Luminal flow induces NADPH oxidase 4 translocation to the nuclei of thick ascending limbs. Physiol Rep. 2016;4: pubmed publisher
    ..Flow-induced Nox4 translocation to the nucleus may play a role in O2 (-)-dependent changes in thick ascending limbs. ..
  62. Dosoki H, Stegemann A, Taha M, Schnittler H, Luger T, Schröder K, et al. Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis. Exp Dermatol. 2017;26:73-81 pubmed publisher
    ..is increasing evidence that oxidative stress is involved in collagen synthesis and myofibroblast activation, the NADPH oxidase (Nox) system is incompletely investigated in the context of human dermal fibroblasts (HDFs) and skin ..
  63. Mohammad A, bon Ramos A, Lee B, Cohen S, Kiani M, Iwata Reuyl D, et al. Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide. Biomolecules. 2017;7: pubmed publisher
    QueF enzymes catalyze the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ?) to 7-aminomethyl-7-deazaguanine (preQ?) in the biosynthetic pathway to the tRNA ..
  64. Wang X, Ding Z, Yang F, Dai Y, Chen P, Theus S, et al. Modulation of myocardial injury and collagen deposition following ischaemia-reperfusion by linagliptin and liraglutide, and both together. Clin Sci (Lond). 2016;130:1353-62 pubmed publisher
    ..Ischaemia-reperfusion increased reactive oxygen species (ROS) generation and expression of NADPH oxidase (p47(phox), p22(phox) and gp91(phox) subtypes), collagens, fibronectin and proinflammatory cytokines (..
  65. Dutta R, Kondeti V, Sharma I, Chandel N, Quaggin S, Kanwar Y. Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI. J Am Soc Nephrol. 2017;28:1421-1436 pubmed publisher
    ..mice had the highest and MIOX-/- mice had the lowest renal levels of Bax, cleaved caspase-3, and NADPH oxidase-4 expression and reactive oxygen species (ROS) generation after cisplatin treatment...
  66. Chiriaco M, Casciano F, Di Matteo G, Gentner B, Claps A, Di Cesare S, et al. Impaired X-CGD T cell compartment is gp91phox-NADPH oxidase independent. Clin Immunol. 2018;193:52-59 pubmed publisher
    ..and demonstrated that human T cells do not express gp91phox and TCR-stimulated ROS generation is gp91phox-NADPH oxidase independent...
  67. Ueda K, Nakajima T, Yoshikawa K, Toya Y, Matsuda F, Shimizu H. Metabolic flux of the oxidative pentose phosphate pathway under low light conditions in Synechocystis sp. PCC 6803. J Biosci Bioeng. 2018;126:38-43 pubmed publisher
    ..The balance between the consumption and production of NADPH suggested that approximately 10% of the total NADPH production was generated by the oxPPP under the low light ..
  68. Liu F, Yang L, Sun X, Zhang H, Pan W, Wang X, et al. NOX2 Mediated-Parvalbumin Interneuron Loss Might Contribute to Anxiety-Like and Enhanced Fear Learning Behavior in a Rat Model of Post-Traumatic Stress Disorder. Mol Neurobiol. 2016;53:6680-6689 pubmed
    ..single prolonged stress (SPS), we assessed the role of hippocampal nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) and parvalbumin (PV) interneurons in the development of PTSD symptoms...
  69. Hu Z, Wang W, Ling J, Jiang C. ?-Mangostin Inhibits ?-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity. Cell Mol Neurobiol. 2016;36:811-20 pubmed publisher
    ..Mechanistic study revealed that ?-M functioned by inhibition of nuclear factor kappa B (NF-?B) and NADPH oxidase. Further, ?-M protected ?-synuclein-induced microglial and direct neurotoxicity...
  70. Souabni H, Wien F, Bizouarn T, Houée Levin C, Refregiers M, Baciou L. The physicochemical properties of membranes correlate with the NADPH oxidase activity. Biochim Biophys Acta Gen Subj. 2017;1861:3520-3530 pubmed publisher
    Phagocytes kill ingested microbes by exposure to high concentrations of toxic reactive species generated by NADPH-oxidases. This membrane-bound electron-transferring enzyme is tightly regulated by cellular signaling cascades...
  71. Wu K, Wu C, Tain Y, Chao Y, Hung C, Tsai P, et al. Effects of high fructose intake on the development of hypertension in the spontaneously hypertensive rats: the role of AT1R/gp91PHOX signaling in the rostral ventrolateral medulla. J Nutr Biochem. 2017;41:73-83 pubmed publisher
    ..The changes in protein expression were measured by Western blot. NADPH oxidase subunit gp91phox and angiotensin II type I receptor were up-regulated in RVLM neuron...
  72. Watanabe R, Suzuki J, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, et al. Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure. Hypertens Res. 2016;39:237-44 pubmed publisher
    ..Moreover, increases in protein expression levels related to oxidative stress and inflammation (NADPH oxidase 4, phospho-nuclear factor-κB and phospho-c-Jun) observed in the hearts of non-treated MI with NTX rats ..
  73. Petrushanko I, Lobachev V, Kononikhin A, Makarov A, Devred F, Kovacic H, et al. Oxidation of ??2+-Binding Domain of NADPH Oxidase 5 (NOX5): Toward Understanding the Mechanism of Inactivation of NOX5 by ROS. PLoS ONE. 2016;11:e0158726 pubmed publisher
    ..Contrary to other members of NADPH-oxidases family, NOX5 has its own regulatory calcium-binding domain and thus could be activated directly by ..
  74. Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, et al. Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4. Autophagy. 2017;13:1420-1434 pubmed publisher
    ..growth factor ?) is one of the major profibrotic cytokines for myofibroblast differentiation and NOX4 (NADPH oxidase 4) has an essential role in TGFB-mediated cell signaling...
  75. Deiana M, Calfapietra S, Incani A, Atzeri A, Rossin D, Loi R, et al. Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. Free Radic Biol Med. 2017;113:539-550 pubmed publisher
    ..with the selective inhibitor of MMPs ARP100 or polyphenol (-)-epicathechin, previously shown to inhibit NADPH oxidase in the same model system, demonstrated that the decrease of the three tight junction proteins was mainly a ..
  76. Yamori W, Shikanai T. Physiological Functions of Cyclic Electron Transport Around Photosystem I in Sustaining Photosynthesis and Plant Growth. Annu Rev Plant Biol. 2016;67:81-106 pubmed publisher
    ..Linear electron transport generates both ATP and NADPH, whereas PSI cyclic electron transport produces ATP without producing NADPH...
  77. Gupta A, Kesherwani M, Velmurugan D, Tripathi T. Fasciola gigantica thioredoxin glutathione reductase: Biochemical properties and structural modeling. Int J Biol Macromol. 2016;89:152-60 pubmed publisher
    ..We also described a homology-based structure of FgTGR. The cofactors (NADPH and FAD) and substrates (GSSG and DTNB) were docked, and two possible binding sites for substrates were identified ..
  78. Vidal S, Tapia Paniagua S, Moriñigo J, Lobo C, García de la Banda I, Balebona M, et al. Effects on intestinal microbiota and immune genes of Solea senegalensis after suspension of the administration of Shewanella putrefaciens Pdp11. Fish Shellfish Immunol. 2016;58:274-283 pubmed publisher
    ..involved in immunological responses, such as complement, lysozyme G and transferrin, and oxidative stress, such as NADPH oxidase and glutation peroxidase...
  79. Raghuraman G, Hsiung J, Zuniga M, Baughman B, Hitchner E, Guzman R, et al. Eotaxin Augments Calcification in Vascular Smooth Muscle Cells. J Cell Biochem. 2017;118:647-654 pubmed publisher
    ..In addition, eotaxin promotes proliferation in VSMCs and triggers oxidative stress in a NADPH oxidase dependent manner...
  80. Yang Z, Bao L, Zhao X, Wang C, Zhou S, Wen L, et al. Nicotinic acid supplementation in diet favored intramuscular fat deposition and lipid metabolism in finishing steers. Exp Biol Med (Maywood). 2016;241:1195-201 pubmed publisher
    Nicotinic acid (NA) acting as the precursor of NAD(+)/NADH and NADP(+)/NADPH, participates in many biochemical processes, e.g. lipid metabolism...
  81. El Gowelli H, Ibrahim K, El Yazbi A, El Mas M. Role of NADPHox/Rho-kinase signaling in the cyclosporine-NSAIDs interactions on blood pressure and baroreflexes in female rats. Life Sci. 2017;185:15-22 pubmed publisher
    ..of CSA are influenced by co-administration of nonsteroidal antiinflammatory drugs (NSAIDs) and if the oxidative NADPH-oxidase (NADPHox)/Rho-kinase (ROCK) pathway mediates this interaction...
  82. Jiang S, Streeter J, Schickling B, Zimmerman K, Weiss R, Miller F. Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning. Cardiovasc Res. 2014;102:79-87 pubmed publisher
    ..Our objective was to investigate the role of the Nox1 NADPH oxidase in cardioprotection provided by IPC...
  83. Miriyala S, Chandra M, Maxey B, Day A, St Clair D, Panchatcharam M. Arjunolic acid ameliorates reactive oxygen species via inhibition of p47(phox)-serine phosphorylation and mitochondrial dysfunction. Int J Biochem Cell Biol. 2015;68:70-7 pubmed publisher
    ..The treatment of neutrophils with PMA induced phosphorylation of Ser345 on p47(phox), a cytosolic component of NADPH oxidase. Furthermore, we observed activated ERK induced phosphorylation of Ser345 in MI neutrophils...
  84. Wallenius J, Maaheimo H, Eerikäinen T. Carbon 13-Metabolic Flux Analysis derived constraint-based metabolic modelling of Clostridium acetobutylicum in stressed chemostat conditions. Bioresour Technol. 2016;219:378-386 pubmed publisher
    ..e. growth rate maximization, ATP maintenance, and NADH/NADPH formation, for flux variance analysis (FVA) was studied in the different modelled conditions...
  85. Pype C, Verbueken E, Saad M, Bars C, Van Ginneken C, Knapen D, et al. Antioxidants reduce reactive oxygen species but not embryotoxicity in the metabolic Danio rerio test (mDarT). Reprod Toxicol. 2017;72:62-73 pubmed publisher
    ..Single dosing of NADPH or omitting toxic components from the MAS preparation did also not reduce embryotoxicity...
  86. Wang Y, Richard M, Top S, Dansette P, Pigeon P, Vessieres A, et al. Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation. Angew Chem Int Ed Engl. 2016;55:10431-4 pubmed publisher
    ..Such conjugates are formed upon metabolism of FCs by liver microsomes in the presence of NADPH and thiols...
  87. Lin H, Zhang H, Walker V, D Agostino J, Hollenberg P. Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds. Drug Metab Dispos. 2017;45:990-999 pubmed publisher
    ..OHEB) carboxylation activity in a reconstituted system was time- and concentration-dependent and required NADPH for MS and OD, but not DZ...
  88. Van der Spek A, Jim K, Karaczyn A, van Beeren H, Ackermans M, Darras V, et al. The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species. Endocrinology. 2018;159:826-835 pubmed publisher
    ..Finally, stimulated neutrophils from female D3KO mice exhibited impaired NADPH-oxidase activity, an important component of the neutrophil bacterial killing machinery...
  89. Forteza R, Salathe M, Miot F, Forteza R, Conner G. Regulated hydrogen peroxide production by Duox in human airway epithelial cells. Am J Respir Cell Mol Biol. 2005;32:462-9 pubmed
    ..of H(2)O(2) produced by airway epithelia, PCR was used to screen nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression in human airway epithelia redifferentiated at the air-liquid interface (ALI) and demonstrated ..
  90. Wang X, Son Y, Chang Q, Sun L, Hitron J, Budhraja A, et al. NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium. Toxicol Sci. 2011;123:399-410 pubmed publisher
    ..In this study, we investigated the role of NADPH oxidase (NOX), one of the major sources of cellular ROS, in Cr(VI)-induced oxidative stress and carcinogenesis...
  91. Bekeschus S, Winterbourn C, Kolata J, Masur K, Hasse S, Bröker B, et al. Neutrophil extracellular trap formation is elicited in response to cold physical plasma. J Leukoc Biol. 2016;100:791-799 pubmed
    ..Plasma-induced neutrophil extracellular trap formation was not dependent on the activity of myeloperoxidase or NADPH oxidase 2 but seemed to involve short-lived molecules...
  92. Suga M, Qin X, Kuang T, Shen J. Structure and energy transfer pathways of the plant photosystem I-LHCI supercomplex. Curr Opin Struct Biol. 2016;39:46-53 pubmed publisher
    ..photosynthesis, and absorbs light energy to generate reducing power for the reduction of NADP+ to NADPH with a quantum efficiency close to 100%...