DECR1

Summary

Gene Symbol: DECR1
Description: 2,4-dienoyl-CoA reductase 1
Alias: DECR, NADPH, SDR18C1, 2,4-dienoyl-CoA reductase, mitochondrial, 2,4-dienoyl-CoA reductase 1, mitochondrial, 4-enoyl-CoA reductase, short chain dehydrogenase/reductase family 18C member 1
Species: human

Top Publications

  1. ncbi Metabolism of metolachlor by a microsomal fraction isolated from grain sorghum (Sorghum bicolor) shoots
    D E Moreland
    Department of Crop Science, North Carolina State University, Raleigh 27695 7620
    Z Naturforsch C 45:558-64. 1990
  2. doi Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease
    Ikuko Mizuta
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, 2 2 B9 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Hum Genet 124:89-94. 2008
  3. ncbi Pro- and antioxidative properties of cortical tissue preparations from human brain exhibiting NMDA-receptor characteristics
    M Elstner
    ,
    Z Naturforsch C 54:438-45. 1999
  4. pmc Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: relationship with peroxisome proliferation
    M Alegret
    , Facultad de Farmacia, , Barcelona, Spain
    Br J Pharmacol 114:1351-8. 1995
  5. ncbi The prophylactic effects of natural water-soluble antioxidant from spinach and apocynin in a rabbit model of lipopolysaccharide-induced endotoxemia
    L Lomnitski
    Bar Ilan University, Ramat Gan, Israel
    Toxicol Pathol 28:588-600. 2000
  6. ncbi Effect of chronic angiotensin II inhibition on the cardiovascular system of the normal rat
    L Gonzalez Bosc
    Cátedra de Biología Celular e Histología, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Am J Hypertens 13:1301-7. 2000
  7. ncbi Release of hydrogen peroxide by rat type II pneumocytes in the prolonged culture
    W J Piotrowski
    Department of Pneumology and Allergology, Medical University of Lodz, Kopcinkiego 22, 90-153, Lodz, Poland
    Toxicol In Vitro 14:85-93. 2000
  8. pmc Release by ultraviolet B (u.v.B) radiation of nitric oxide (NO) from human keratinocytes: a potential role for nitric oxide in erythema production
    G Deliconstantinos
    Department of Physiology, University of Athens Medical School, Greece
    Br J Pharmacol 114:1257-65. 1995
  9. ncbi Effects of antioxidants apocynin and the natural water-soluble antioxidant from spinach on cellular damage induced by lipopolysaccaride in the rat
    L Lomnitski
    Bar Ilan University, Ramat Gan, Israel
    Toxicol Pathol 28:580-7. 2000
  10. ncbi Acute and subacute toxicity study of water-soluble polyalkylsulfonated C60 in rats
    H H Chen
    National Laboratory Animal Breeding and Research Center, National Science Council, Nankang, Taiwan
    Toxicol Pathol 26:143-51. 1998

Research Grants

  1. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
  2. Christopher S Wilcox; Fiscal Year: 2014
  3. Keer Sun; Fiscal Year: 2016
  4. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2013
  5. Role of Neuronal NOS in Neurotoxicity
    Stephen M Black; Fiscal Year: 2010
  6. Suresh C Tyagi; Fiscal Year: 2016
  7. Interactions Between Inflammation, Oxidant Stress and Cardiovascular Disease
    David G Harrison; Fiscal Year: 2013
  8. Mechanisms of Neuroprotection by Astrocytes in Alcohol Abuse
    James Haorah; Fiscal Year: 2012
  9. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
  10. ClC-3 Chloride Ion Channels in Vascular Smooth Muscle
    Fred Lamb; Fiscal Year: 2009

Detail Information

Publications920 found, 100 shown here

  1. ncbi Metabolism of metolachlor by a microsomal fraction isolated from grain sorghum (Sorghum bicolor) shoots
    D E Moreland
    Department of Crop Science, North Carolina State University, Raleigh 27695 7620
    Z Naturforsch C 45:558-64. 1990
    ..70 and 0.48, respectively. The microsomal reaction required NADPH and oxygen, and was inhibited by carbon monoxide, with the inhibition being partially reversed by actinic light...
  2. doi Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease
    Ikuko Mizuta
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, 2 2 B9 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Hum Genet 124:89-94. 2008
    ..Our genetic analysis suggests that CALB1 is associated with PD independently of SNCA, and that FGF20 is associated with PD synergistically with SNCA...
  3. ncbi Pro- and antioxidative properties of cortical tissue preparations from human brain exhibiting NMDA-receptor characteristics
    M Elstner
    ,
    Z Naturforsch C 54:438-45. 1999
    ..CTP contain measurable NAD(P)H oxidoreductase activity, producing OH- radical- type oxidants at the expense of NADPH and (to a lesser extent) NADH as electron donors, shown as redox-cycling of 2-methyl-5-hydroxy-1,4-naphthoquinone, ..
  4. pmc Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: relationship with peroxisome proliferation
    M Alegret
    , Facultad de Farmacia, , Barcelona, Spain
    Br J Pharmacol 114:1351-8. 1995
    ..in the microsomal electron transport chains, NADH cytochrome b5 reductase was not affected by fibrate treatment, NADPH cytochrome c reductase activity was enhanced (BFB = GFB > CFB), whereas NADH cytochrome c reductase activity ..
  5. ncbi The prophylactic effects of natural water-soluble antioxidant from spinach and apocynin in a rabbit model of lipopolysaccharide-induced endotoxemia
    L Lomnitski
    Bar Ilan University, Ramat Gan, Israel
    Toxicol Pathol 28:588-600. 2000
    ..The antioxidants used were a water-soluble natural antioxidant (NAO) from spinach and the NADPH oxidase inhibitor, apocynin...
  6. ncbi Effect of chronic angiotensin II inhibition on the cardiovascular system of the normal rat
    L Gonzalez Bosc
    Cátedra de Biología Celular e Histología, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Am J Hypertens 13:1301-7. 2000
    ..DNA, cGMP, collagen, degree of fibrosis, and nitric oxide synthase-NADPH-diaphorase-dependent activity in the heart and arteries were determined. Only significant differences (P < ...
  7. ncbi Release of hydrogen peroxide by rat type II pneumocytes in the prolonged culture
    W J Piotrowski
    Department of Pneumology and Allergology, Medical University of Lodz, Kopcinkiego 22, 90-153, Lodz, Poland
    Toxicol In Vitro 14:85-93. 2000
    ..Both mitochondrial respiratory chain and membrane-bound NADPH-oxidase may be responsible for the production of H(2)O(2) by T II pneumocytes.
  8. pmc Release by ultraviolet B (u.v.B) radiation of nitric oxide (NO) from human keratinocytes: a potential role for nitric oxide in erythema production
    G Deliconstantinos
    Department of Physiology, University of Athens Medical School, Greece
    Br J Pharmacol 114:1257-65. 1995
    ..4. NOS isolated from the keratinocyte cytosol was constitutively expressed and was dependent on NADPH, Ca2+/calmodulin, tetrahydrobiopterin and flavins. 5...
  9. ncbi Effects of antioxidants apocynin and the natural water-soluble antioxidant from spinach on cellular damage induced by lipopolysaccaride in the rat
    L Lomnitski
    Bar Ilan University, Ramat Gan, Israel
    Toxicol Pathol 28:580-7. 2000
    ..The antioxidants used were a water-soluble natural antioxidant from spinach (NAO) and the NADPH oxidase inhibitor apocynin...
  10. ncbi Acute and subacute toxicity study of water-soluble polyalkylsulfonated C60 in rats
    H H Chen
    National Laboratory Animal Breeding and Research Center, National Science Council, Nankang, Taiwan
    Toxicol Pathol 26:143-51. 1998
    ..hydroxylase, but an increased level of kidney cytochrome P-450-dependent monooxygenase activities, including NADPH-cytochrome P-450 reductase. The significance of these enzyme alterations was not well determined...
  11. ncbi Modulation of noninduced and phorbol ester-induced generation of superoxide anion by free liposomes and liposomes containing dexamethasone
    F Bellemare
    Centre de Recherche, , Ste-Foy, , Canada
    Immunopharmacol Immunotoxicol 19:121-34. 1997
    ..almost 8 minutes with PMA induction and consequently led to the conclusion that liposomes modified the activity of NADPH oxidase as well as that of protein kinase C...
  12. ncbi Subcellular localization of docosahexaenoic acid and arachidonic acid omega-hydroxylation activity in the brain, liver and colonic adenocarcinoma
    M Yamane
    Department of Biochemistry, Tokyo Medical College, Japan
    J Chromatogr A 730:91-8. 1996
    ..Each precipitate or supernatant was incubated with NADPH and docosahexaenoic acid or arachidonic acid as a substrate for 30 min at 37 degrees c under aerobic conditions...
  13. ncbi Complexation of membrane-bound enzyme systems
    D Muller-Enoch
    Department of Physiological Chemistry, Universitat Ulm, Germany
    Z Naturforsch C 55:747-52. 2000
    The effect of changes in the N-terminal membrane-binding domain of cytochrome P450 forms and NADPH-cytochrome P450 reductase types on the cytochrome P450-dependent monooxygenase activities, has been examined...
  14. ncbi Erythrocytes may synthesize their own nitric oxide
    B C Jubelin
    Department of Surgery, Tulane University Medical Center, New Orleans, Louisiana 70112, USA
    Am J Hypertens 9:1214-9. 1996
    ..To characterize erythrocytes (RBCs), we used NADPH diaphorase labeling, as well as antibodies to the three known types of NO synthase (NOS 1, 2, and 3), and to a ..
  15. ncbi Regulation of pathways of glucose metabolism in the kidney. The activity of the pentose phosphate pathway, glycolytic route and the regulation of phosphofructokinase in the kidney of lean and genetically obese (ob/ob) mice; comparison with effects of diab
    M Sochor
    Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, London, United Kingdom
    Horm Metab Res 20:676-81. 1988
    The activities of enzymes of the glycolytic route, the pentose phosphate pathway and NADPH-linked enzymes have been measured in the kidneys of genetically obese (ob/ob) mice and their lean litter mates...
  16. ncbi [Studies on relationships between the inhibition of human neutrophil NADPH oxidase by anti-inflammatory drugs and development of bacterial infections]
    S Umeki
    Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 64:1184-91. 1990
    ..acid, ASA; salicylic acid, SA; indomethacin, IM; hydrocortisone, HC) on the respiratory burst oxidase (NADPH oxidase) from human neutrophils in both whole cell and fully soluble (cell-free) systems were investigated...
  17. pmc Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles
    R C Babbedge
    Biomedical Sciences Division, King s College, University of London
    Br J Pharmacol 110:225-8. 1993
    ..9 +/- 0.1 microM (n = 6). NOS activity is dependent on the presence of both exogenous CaCl2 and NADPH. The inhibitory potency of 7-NI remained unaltered in the presence of different concentrations of either CaCl2 (0...
  18. ncbi Oxido-reductive functions of Entamoeba histolytica in relation to virulence
    S Kumar
    Division of Biochemistry, Central Drug Research Institute, Lucknow, India
    Ann Trop Med Parasitol 86:239-48. 1992
    ..histolytica. However, both NADH and NADPH increased NBT reduction several-fold, the effect being greater with NADPH...
  19. ncbi Inhibitory effects of methanol extract of seeds of Job's Tears (Coix lachryma-jobi L. var. ma-yuen) on nitric oxide and superoxide production in RAW 264.7 macrophages
    W G Seo
    Department of Microbiology, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea
    Immunopharmacol Immunotoxicol 22:545-54. 2000
    ..7 cells in dose- and time-dependent manners, possibly by interfering with NADPH oxidase machinery of macrophages...
  20. ncbi "4S" polycyclic aromatic hydrocarbon binding protein. Its role as a benzo(a) pyrene cytosolic carrier to the microsomes of DBA/2N mouse liver
    M T Masucci
    Institute of General Pathology, Ist Medical School, University of Naples, Italy
    Tumori 75:211-6. 1989
    ..The radioactive benzo(a)pyrene bound to microsomes was oxidated in the presence of NADPH regenerating system...
  21. ncbi Protein-A activates membrane bound multicomponent enzyme complex, NADPH oxidase in human neutrophils
    A Mishra
    Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    Immunopharmacol Immunotoxicol 21:683-94. 1999
    ..To understand the mechanism of protein-A induced O2- generation; NADPH oxidase activity was measured in cell free system using NADPH as a substrate...
  22. pmc Inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate binding sites in smooth muscle
    L Zhang
    Department of Pharmacology 318, University of Nevada School of Medicine, Reno 89557
    Br J Pharmacol 109:905-12. 1993
    ..5. [3H]-InsP3 binding in subcellular fractions separated by discontinuous sucrose density gradients followed NADPH-cytochrome c reductase activity, suggesting an intracellular localization for the majority of InsP3 receptors in ..
  23. ncbi Hydrogen peroxide modulation of the superoxide anion production by stimulated neutrophils
    I Dekaris
    Department of Ophthalmology, GH "Sveti Duh, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 20:103-17. 1998
    ..O2 production is probably due to alteration of the LPS receptor conformation rather than effecting directly NADPH-oxidase...
  24. ncbi The oxidative processes induced in cell suspensions of Solanum species by culture filtrate of Phytophthora infestans
    L Polkowska Kowalczyk
    Department of Plant Biochemistry, Polish Academy of Sciences, Warsaw
    Z Naturforsch C 56:235-44. 2001
    ..In all cells probably the membrane-bound NADPH oxidase, was responsible for the ROS production...
  25. ncbi Effect of lentinan on superoxide dismutase enzyme activity in vitro
    J Feher
    Second Department of Medicine, Semmelweis University, Budapest, Hungary
    Immunopharmacol Immunotoxicol 11:55-61. 1989
    ..No significant antioxidant (free radical scavenger) effect has been observed in NADPH-induced and Fe3+-stimulated lipid peroxidation and in xanthine-xanthine oxidase system.
  26. ncbi A direct, highly sensitive fluorometric assay for a microsomal cytochrome P450-mediated O-demethylation using a novel coumarin analog as substrate
    R Roser

    Z Naturforsch C 55:915-22. 2000
    ..When 3-chloro-7-methoxy-4-methylcoumarin was incubated in the presence of MgCl2 and NADPH with rat liver microsomes, a continuous increase of the fluorescence could be measured...
  27. ncbi Moderately different NADPH-diaphorase positivity in the selected peripheral nerves after ischemia/ reperfusion injury of the spinal cord in rabbit
    Monika Lackova
    Institute of Neurobiology, Slovak Academy of Sciences, Soltesovej 4, Kosice, 040 01, Slovak Republic
    Cell Mol Neurobiol 26:1311-25. 2006
    1. To vicariously investigate the nitric oxide synthase (NOS) production after spinal cord injury, NADPH-d histochemistry was performed on the selected peripheral nerves of adult rabbits 7 days after ischemia...
  28. ncbi Diphenylene iodonium as an inhibitor of the NADPH oxidase complex of bovine neutrophils. Factors controlling the inhibitory potency of diphenylene iodonium in a cell-free system of oxidase activation
    J Doussiere
    Departement de Biologie Moleculaire et Structurale, Centre d Etudes Nucléaires, Grenoble, France
    Eur J Biochem 208:61-71. 1992
    ..iodonium (Ph2I), a lipophilic reagent, is an efficient inhibitor of the production of O2- by the activated NADPH oxidase of bovine neutrophils...
  29. pmc Inhibitory actions of diphenyleneiodonium on endothelium-dependent vasodilatations in vitro and in vivo
    Y X Wang
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Br J Pharmacol 110:1232-8. 1993
    ..The inhibitory effect of DPI (3 x 10(-7) M) on ACh-induced relaxation was prevented by pretreatment with NADPH (5 x 10(-3) M) and FAD (5 x 10(-4) M) but not L-arginine (L-Arg, 2 x 10(-3) M)...
  30. ncbi Scaling of some metabolic enzymes in liver of a freshwater teleost: an adaptive mechanism
    G Tripathi
    Department of Zoology, J N V University, Jodhpur, India
    Z Naturforsch C 54:1103-6. 1999
    ..malate dehydrogenase (cMDH) decreases with the increasing body mass of the fish which reflects reduction in NADPH production and, in turn, reduced lipogenesis in liver of larger individuals...
  31. ncbi Inhibition of the neutrophil NADPH oxidase by folic acid and antagonists of the folic acid metabolism
    G F Weber
    College of Medicine, Department of Biochemistry, University of South Alabama, Mobile 36688
    Immunopharmacol Immunotoxicol 14:523-38. 1992
    ..The compounds were found to be partial competitive inhibitors of the NADPH oxidase, their activity apparently increasing with larger substituents at the 10 position...
  32. ncbi On-line high-performance liquid chromatographic-electrospray ionization mass spectrometric method for the study of tamoxifen metabolism
    R M Jones
    MRC Toxicology Unit, University of Leicester, UK
    J Chromatogr A 722:249-55. 1996
    ..Mouse liver microsomal preparations were incubated with tamoxifen in the presence of NADPH and MgCl2. The metabolites formed were separated and analyzed by the optimized HPLC-ESI-MS system...
  33. ncbi Effects of ethyl carbamate and its metabolites on the antibody response in splenocyte cultures from female Balb/C mice
    T C Jeong
    Toxicology Research Center, Korea Research Institute of Chemical Technology, Taejon
    Immunopharmacol Immunotoxicol 18:91-103. 1996
    ..A pre-incubation study with phenobarbital-induced liver microsomes in the presence of NADPH-generating system showed that the antibody response was suppressed by ethyl carbamate when splenocytes were pre-..
  34. ncbi [Studies on effects of new quinolones on superoxide production--with special reference to NADPH oxidase]
    S Umeki
    Department of Medicine, Toshida-kai Kumeda Hospital
    Kansenshogaku Zasshi 67:998-1004. 1993
    ..tosufloxacin (TFLX), lomefloxacin (LFLX) and temafloxacin (TMFX), on the superoxide production of human neutrophil NADPH oxidase were investigated...
  35. ncbi Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis
    G Waksman
    Laboratory of Molecular Biophysics, Rockefeller University, New York, NY 10021
    J Mol Biol 236:800-16. 1994
    ..mechanism involves the transfer of reducing equivalents from reduced nicotinamide adenine dinucleotide phosphate (NADPH) to a disulfide bond in the enzyme, via a flavin adenine dinucleotide (FAD)...
  36. ncbi Blue light mediated photoreduction of the flavoprotein NADPH-cytochrome P450 reductase. A Förster-type energy transfer
    D Muller-Enoch
    Abteilung Physiologische Chemie, Universitat Ulm, Germany
    Z Naturforsch C 52:605-14. 1997
    ..coefficients of the fluorophores umbelliferone, FAD and FMN and of the FAD and FMN containing flavoprotein NADPH-cytochrome P450 reductase of different oxydation-reduction states are documented...
  37. ncbi 3 alpha-Hydroxysteroid-5 beta-oxidoreductase in tissue cultures of Digitalis lanata
    U Stuhlemmer
    Pharmazeutisches Institut, , , Bundesrepublik Deutschland
    Z Naturforsch C 48:713-21. 1993
    ..0 and 42 degrees C. The energy of activation was 56.2 kJ/mol and the enzyme reaction was found to be NADPH-dependent. SH reagents were essential for enzyme activity.(ABSTRACT TRUNCATED AT 250 WORDS)
  38. ncbi Characterization of two thioredoxins in pig heart including a new mitochondrial protein
    J Bodenstein
    , Bundesrepublik Deutschland
    Z Naturforsch C 46:270-9. 1991
    ..Heart extracts were also shown to contain a NADPH-specific thioredoxin reductase of the known mammalian type...
  39. ncbi Inhibition of microsomal lipid peroxidation and monooxygenase activities by eugenol
    E Nagababu
    Biochemistry Division, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad
    Free Radic Res 20:253-66. 1994
    ..study, we examined the effect of eugenol on microsomal mixed function oxidase mediated peroxidation using Fe+3-ADP-NADPH, carbon tetrachloride (CCL4)-NADPH and cumene hydroperoxide (CumOOH) systems...
  40. ncbi Inhibition of oxygen radical formation by methylene blue, aspirin, or alpha-lipoic acid, prevents bacterial-lipopolysaccharide-induced fever
    Walter Riedel
    Max Planck Institute for Physiological and Clinical Research, W G Kerckhoff Institute, Bad Nauheim, Germany
    Mol Cell Biochem 247:83-94. 2003
    Phagocytic cells contain NADPH oxidase that they use for host defense by catalyzing the production of superoxide...
  41. ncbi Preconditioning protects endothelium by preventing ET-1-induced activation of NADPH oxidase and xanthine oxidase in post-ischemic heart
    Monika Duda
    Department of Clinical Physiology, Postgraduate Medical School, Marymoncka 99, 01 813 Warsaw, Poland
    J Mol Cell Cardiol 42:400-10. 2007
    ..Myocardial outflow of ET-1 and O(2)(-) and functional recoveries were followed during reperfusion. NADPH oxidase and xanthine oxidase (XO) activities were measured in cardiac homogenates...
  42. doi Improved NADPH supply for xylitol production by engineered Escherichia coli with glycolytic mutations
    Jonathan W Chin
    Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA
    Biotechnol Prog 27:333-41. 2011
    ..was previously shown to produce high levels of xylitol from a mixture of glucose and xylose when expressing NADPH-dependent xylose reductase from Candida boidinii (CbXR) (Cirino et al., Biotechnol Bioeng. 2006;95:1167-1176)...
  43. ncbi The reduction of acetylpyridine adenine dinucleotide by NADH: is it a significant reaction of proton-translocating transhydrogenase, or an artefact?
    S N Stilwell
    School of Biochemistry, University of Birmingham, Edgbaston, UK
    Biochim Biophys Acta 1320:83-94. 1997
    ..It has separate binding sites for NAD+/NADH (on domain I of the protein) and for NADP+/NADPH (on domain III)...
  44. ncbi Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes
    H L Bonkovsky
    Department of Medicine, Winship Cancer Center, Emory University, Atlanta, GA 30322
    Eur J Biochem 189:155-66. 1990
    ..In a reconstituted system containing purified heme oxygenase, NADPH-cytochrome reductase, biliverdin reductase and NADPH, the Km for free heme was 3.8 +/- 0...
  45. ncbi Regulation of aerobic fermentation in Leishmania donovani promastigotes by NADP+-dependent malic enzyme
    V Saadalla
    Chemistry Department, College of Science, University of Baghdad, Iraq
    Ann Trop Med Parasitol 81:687-92. 1987
    ..18 and 0.12 mM, respectively. The enzyme exhibited a broad pH optimum of 7.5-8.0. Pyruvate, NADPH and OA inhibited the reaction in a competitive manner with apparent Ki values of 0.2, 0.04 and 0...
  46. ncbi Ability of cytosolic malate dehydrogenase and lactate dehydrogenase to increase the ratio of NADPH to NADH oxidation by cytosolic glycerol-3-phosphate dehydrogenase
    L A Fahien
    Department of Pharmacology, University of Wisconsin Medical School, 1300 University Ave, Madison, Wisconsin 53706, USA
    Arch Biochem Biophys 364:185-94. 1999
    ..0 to 7.1) and in the presence of physiological (1.0 mM) levels of free Mg2+, the Vmax of the NADPH oxidation is only slightly lower than the Vmax of NADH oxidation in the cytosolic glycerol-3-phosphate ..
  47. ncbi Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes
    Tsutomu Shimada
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 23rd and Pierce Avenues, Nashville, TN 37232 0146, USA
    Arch Biochem Biophys 435:207-16. 2005
    ..system was developed to detect interactions of human cytochromes P450 (P450) with the accessory proteins NADPH-P450 reductase and cytochrome b(5) (b(5)) using an enzyme-linked affinity approach...
  48. ncbi Colocalization of somatostatin receptor subtypes (SSTR1-5) with somatostatin, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase in the rat hypothalamus
    Ujendra Kumar
    Faculty of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of British Columbia, Vancouver, Canada
    J Comp Neurol 504:185-205. 2007
    ..In addition, we also demonstrated SSTRs colocalization with SST, NADPH-diaphorase (NADPH-d), and tyrosine hydroxylase (TH)...
  49. ncbi The antifolate 10-deazaaminopterin inhibits neutrophil chemotaxis and superoxide generation
    G F Weber
    College of Medicine, Department of Biochemistry, University of South Alabama, Mobile 36688
    Immunopharmacol Immunotoxicol 13:379-93. 1991
    ..Therefore, the effects on chemotaxis and NADPH oxidase appear to be reversible and not due to metabolic transformation of the dihydrofolate reductase inhibitor.
  50. ncbi Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA
    N A Cohen
    Division of Developmental Therapeutics, University of Maryland Cancer Center, Baltimore 21201
    Cancer Res 51:4360-6. 1991
    ..for their interaction with the DNA of L1210 cells in the presence and absence of rat hepatic microsomes and NADPH. Alkaline elution was used to study 3 types of DNA lesions...
  51. ncbi Relationships between NADPH diaphorase staining and neuronal, endothelial, and inducible nitric oxide synthase and cytochrome P450 reductase immunoreactivities in guinea-pig tissues
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Vic, Australia
    Histochem Cell Biol 107:19-29. 1997
    The presence of NADPH diaphorase staining was compared with the immunohistochemical localization of four NADPH-dependent enzymes-neuronal (type I), inducible (type II), and endothelial (type III) nitric oxide synthase (NOS) and ..
  52. pmc Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes
    Tsukasa Kawahara
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    BMC Evol Biol 7:178. 2007
    The reactive oxygen-generating NADPH oxidases (Noxes) function in a variety of biological roles, and can be broadly classified into those that are regulated by subunit interactions and those that are regulated by calcium...
  53. ncbi Localization of immunoreactive GABA and enkephalin and NADPH-diaphorase-positive neurons in fetal striatal grafts in the quinolinic-acid-lesioned rat neostriatum
    R C Roberts
    Department of Neurology, Massachusetts General Hospital, Boston 02114
    J Comp Neurol 274:406-21. 1988
    ..of labeled neurons in the grafts, the localization of immunoreactive GABA and leucine-enkephalin (ENK) and of NADPH-diaphorase (NADPH-d) activity was examined in fetal striatal grafts at the light and electron microscopic levels...
  54. ncbi Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues
    Aldo Gutierrez
    Department of Biochemistry and Biological NMR Centre, University of Leicester, UK
    Eur J Biochem 270:2612-21. 2003
    ..of interflavin electron transfer (FADsq - FMNsq-->FADox - FMNhq) in CPR reduced at the two-electron level with NADPH is 55 +/- 2 s-1, whereas with dithionite-reduced enzyme the observed rate is 11 +/- 0...
  55. doi Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition
    Torsten Schlüter
    Department of Physiology, University of Greifswald, Greifswalder Street 11C, D17495 Greifswald, Karlsburg, Germany
    Cardiovasc Res 80:271-9. 2008
    The present study was designed to test the hypothesis that NADPH oxidase inhibition with apocynin would lower blood pressure and improve endothelial function in spontaneously hypertensive rats (SHRs)...
  56. ncbi The effect of L-acetylcarnitine on some reproductive functions in the oligoasthenospermic rat
    S Palmero
    Istituto di Fisiologia Generale, , Italy
    Horm Metab Res 22:622-6. 1990
    ..the enzymatic activities evaluated as biochemical markers of testicular function both lactate dehydrogenase and NADPH-cytochrome P 450-reductase increased significantly (P less than 0.05) after treatment with LAC in normal rats...
  57. ncbi Characterization of the flavoprotein moieties of NADPH-sulfite reductase from Salmonella typhimurium and Escherichia coli. Physicochemical and catalytic properties, amino acid sequence deduced from DNA sequence of cysJ, and comparison with NADPH-cytochrom
    J Ostrowski
    Howard Hughes Medical Institute Laboratory, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 264:15796-808. 1989
    b>NADPH-sulfite reductase flavoprotein (SiR-FP) was purified from a Salmonella typhimurium cysG strain that does not synthesize the hemoprotein component of the sulfite reductase holoenzyme. cysJ, which codes for SiR-FP, was cloned from S...
  58. pmc Arthritis suppression by NADPH activation operates through an interferon-beta pathway
    Peter Olofsson
    Biovitrum AB, Arvid Wallgrens Backe 20, Goteborg, Sweden
    BMC Biol 5:19. 2007
    A polymorphism in the activating component of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex, neutrophil cytosolic factor 1 (NCF1), has previously been identified as a regulator of arthritis severity in mice and ..
  59. ncbi Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells
    Stavros Selemidis
    Bernard O Brien Institute of Microsurgery, University of Melbourne, Fitzroy, Victoria 3065, Australia
    Cardiovasc Res 75:349-58. 2007
    Endothelial NADPH oxidase is a major source of superoxide in blood vessels and is implicated in the oxidative stress accompanying vascular diseases, including atherosclerosis...
  60. ncbi Mycobacterium tuberculosis FprA, a novel bacterial NADPH-ferredoxin reductase
    Federico Fischer
    Dipartimento di Fisiologia e Biochimica Generali, Universita degli Studi di Milano, Milano, Italy
    Eur J Biochem 269:3005-13. 2002
    ..Kinetic parameters were determined and the specificity constant (kcat/Km) for NADPH was two orders of magnitude larger than that of NADH...
  61. ncbi Metabolism of daunomycin (NSC-82151) in vitro and the chemotherapeutic activity of isolated metabolites in vivo
    M A Asbell
    Life Sciences Division, Arthur D. Little, Inc, Cambridge, MA, USA
    Cancer Chemother Rep 56:315-20. 1972
    ..conversion), by an aerobic, cell-free system containing nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) and the 100,000 x g supernatant fluid of rat kidneys...
  62. ncbi Time course of expression of neuropeptide Y, calcitonin gene-related peptide, and NADPH diaphorase activity in neurons of the developing murine bowel and the appearance of 5-hydroxytryptamine in mucosal enterochromaffin cells
    T A Branchek
    Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    J Comp Neurol 285:262-73. 1989
    ..and of those visualized by the histochemical demonstration of reduced nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase activity...
  63. ncbi Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat
    Margarita Díaz-Flores
    Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS Mexico, Mexico
    Life Sci 78:2601-7. 2006
    Hyperglycemia is associated with metabolic disturbances affecting cell redox potential, particularly the NADPH/NADP+ ratio and reduced glutathione levels...
  64. ncbi Studies on chemiluminescence and protein kinase-C activity of cisplatin treated mouse peritoneal exudate cells
    B Geetha
    School of Biotechnology, Department of Zoology, Banaras Hindu University, Varanasi, India
    Immunopharmacol Immunotoxicol 13:1-10. 1991
    ..The activation of PK-C could result in stimulation of NADPH-oxidase resulting in increased levels of chemiluminescence...
  65. ncbi Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement
    C E Grimshaw
    Whittier Institute, San Diego, California
    J Biol Chem 267:15334-9. 1992
    Kinetic constants for the interaction of NADH and NADPH with native rat dihydropteridine reductase (DHPR) and an Escherichia coli expressed mutant (D-37-I) have been determined...
  66. pmc Temporal changes in the expression of mRNA of NADPH oxidase subunits in renal epithelial cells exposed to oxalate or calcium oxalate crystals
    Saeed R Khan
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA
    Nephrol Dial Transplant 26:1778-85. 2011
    ..We have hypothesized that Ox and CaOx crystals activate NADPH oxidase through upregulation of its various subunits.
  67. ncbi Nadph-diaphorase activity in corpus allatum cells of the cockroach, Diploptera punctata
    A S Chiang
    Department of Life Science, National Tsing Hua University, Hsinchu, 300, Taiwan, Republic of China
    Insect Biochem Mol Biol 30:747-53. 2000
    Using the fixation insensitive NADPH-diaphorase reaction as a histochemical marker for the enzyme nitric oxide synthase (NOS), we investigated the possible sites of putatively NOS-related NADPH-diaphorase in the brain and retrocerebral ..
  68. ncbi Binding of FAD to cytochrome b558 is facilitated during activation of the phagocyte NADPH oxidase, leading to superoxide production
    Shukichi Hashida
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812
    J Biol Chem 279:26378-86. 2004
    The superoxide-producing phagocyte NADPH oxidase can be reconstituted in a cell-free system. The activity of NADPH oxidase is dependent on FAD, but the physiological status of FAD in the oxidase is not fully elucidated...
  69. ncbi Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin
    Peter V Usatyuk
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:23284-95. 2007
    Although the actin cytoskeleton has been implicated in the control of NADPH oxidase in phagocytosis, very little is known about the cytoskeletal regulation of endothelial NADPH oxidase assembly and activation...
  70. pmc Role of NADPH oxidase in retinal vascular inflammation
    Mohamed Al-Shabrawey
    Oral Biology and Anatomy, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912, USA
    Invest Ophthalmol Vis Sci 49:3239-44. 2008
    In another study, it was demonstrated that NADPH oxidase-derived reactive oxygen species (ROS) are important for ischemia-induced increases in vascular endothelial growth factor (VEGF) and retinal neovascularization...
  71. doi Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane
    Jamel El-Benna
    INSERM, U773, CRB3, Paris 75018, France
    Semin Immunopathol 30:279-89. 2008
    ..The enzyme responsible for O2* production is called the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase or respiratory burst oxidase...
  72. pmc A2A adenosine receptor deficiency leads to impaired tracheal relaxation via NADPH oxidase pathway in allergic mice
    A Nadeem
    Department of Physiology, Health Sciences Center North, West Virginia University, Morgantown, WV 26505 9229, USA
    J Pharmacol Exp Ther 330:99-108. 2009
    ..However, no study has yet explored the role of A(2A)AR in relation to NADPH oxidase in murine tracheas in vitro, which may lead to altered smooth muscle relaxation in asthma...
  73. ncbi [Effects of NADPH oxidase inhibition on cardiac function and myocardial calcium regulatory proteins in rabbits with heart failure]
    Yu Liu
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:883-6. 2009
    To investigate the effects of NADPH oxidase inhibition on cardiac function and myocardial calcium regulatory proteins mRNA expressions in rabbits with heart failure (HF).
  74. ncbi Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox)
    Xiaoxian Zhao
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    J Biol Chem 277:25385-92. 2002
    The NADPH oxidase of human monocytes is activated upon exposure to opsonized zymosan and a variety of other stimuli to catalyze the formation of superoxide anion...
  75. ncbi Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5)
    Botond Banfi
    Department of Biochemistry, University of Geneva, CH 1211 Geneve, Switzerland
    J Biol Chem 279:18583-91. 2004
    b>NADPH oxidase 5 (NOX5) is a homologue of the gp91(phox) subunit of the phagocyte NADPH oxidase...
  76. ncbi Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis
    Igor Mosyagin
    Institute of Pharmacology, Ernst Moritz Arndt University, Greifswald, Germany
    J Clin Psychopharmacol 24:613-7. 2004
    ..receptors release, followed by induction of granulocyte proliferation and induction of myeloperoxidase (MPO) and NADPH-oxidase...
  77. pmc Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells
    Richard Hu
    Department of Veterans Affairs University of California, Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, Calif 90073, USA
    Pancreatology 7:332-40. 2007
    ..The aims of this study were to determine the presence and role of the NADPH oxidase system in mediating alcohol effects on PaSCs with specific emphasis on proliferation.
  78. doi Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR
    Jens O Krömer
    Biochemical Engineering Institute, Saarland University, Saarbrucken, Germany
    Microbiology 154:3917-30. 2008
    ..It also showed metabolic flux rerouting in response to the deletion. NADPH metabolism was strongly altered...
  79. pmc NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits
    Yu Long Li
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Cardiovasc Res 75:546-54. 2007
    ..b>NADPH oxidase-derived superoxide anion mediates the effects of Ang II in many organs...
  80. ncbi Functional interactions in cytochrome P450BM3: flavin semiquinone intermediates, role of NADP(H), and mechanism of electron transfer by the flavoprotein domain
    M B Murataliev
    Department of Entomology and Center for Toxicology, University of Arizona, Tucson, Arizona 85721 0036, USA
    Biochemistry 36:8401-12. 1997
    ..from Bacillus megaterium utilizing tightly bound FAD and FMN cofactors to transfer reducing equivalents from NADPH to the heme active site...
  81. ncbi Ultrastructure of NADPH diaphorase-positive nerve fibers and their terminals in the rat cerebral arterial system
    A Tsuchida
    Department of Neurosurgery, Fukui Medical University, Matsuoka, Yoshida gun, 910 1193, Fukui, Japan
    J Chem Neuroanat 21:267-75. 2001
    ..nerve fibers and their terminals by means of nicotinamide adenine dinucleotide hydrogen phosphate-diaphorase (NADPH-d) histochemistry...
  82. ncbi Two mechanisms for oxidation of cytosolic NADPH by Kluyveromyces lactis mitochondria
    Karin M Overkamp
    Kluyver Laboratory of Biotechnology, Delft University of Technology, Julianalaan 67, NL 2628 BC Delft, The Netherlands
    Yeast 19:813-24. 2002
    ..lactis mitochondria to oxidize cytosolic NADPH. This would allow for a re-routing of glucose dissimilation via the pentose-phosphate pathway...
  83. pmc Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA
    Kirsty J McLean
    Department of Biochemistry, University of Leicester, The Adrian Building, University Road, UK
    Biochem J 372:317-27. 2003
    ..FprA reduces various electron acceptors using either NADPH or NADH as the electron donor, but discriminates in favour of NADPH (apparent K (m) for NADH=50.6+/-3...
  84. pmc Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH
    Sabrina Serpillon
    Department of Physiology, New York Medical College, Valhalla, NY, USA
    Am J Physiol Heart Circ Physiol 297:H153-62. 2009
    ..Our aim was to determine whether NADPH oxidase (Nox) is a source of O(2)(-) and whether glucose-6-phosphate dehydrogenase (G6PD)-derived NADPH plays a ..
  85. ncbi Metabolic phenotype of phosphoglucose isomerase mutants of Corynebacterium glutamicum
    Achim Marx
    Degussa AG, Feed Additives, R and D Biotechnology, Kantstr 2, D 33790 Halle, Westf, Germany
    J Biotechnol 104:185-97. 2003
    ..L-lysine production of the Corynebacterium glutamicum strain MH20-22B correlates with the extent of intracellular NADPH supply. Some alternative metabolic engineering strategies to increase intracellular NADPH supply in the C...
  86. ncbi Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress
    Srinivasa R Datla
    Bernard O Brien Institute of Microsurgery, University of Melbourne, Victoria, Australia
    Hypertension 50:636-42. 2007
    ..endothelial cells may suppress superoxide generation of from reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase. In this study, we examined the consequence of HO-1 induction in vivo on NADPH oxidase activity...
  87. pmc NADPH-diaphorase expression in the meibomian glands of rat palpebra in postnatal development
    D Kluchova
    Dept of Anatomy, Medical Faculty, University of P J Safarik, Kosice, Slovakia
    Eur J Histochem 54:e47. 2010
    ..There is good evidence to suggest that nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) is a surrogate for neuronal nitric oxide synthase (NOS)...
  88. ncbi Comparative study of monomeric reconstituted and membrane microsomal monooxygenase systems of the rabbit liver. I. Properties of NADPH-cytochrome P450 reductase and cytochrome P450 LM2 (2B4) monomers
    I P Kanaeva
    Institute of Biological and Medical Chemistry, Russian Academy of Medical Sciences, Moscow
    Arch Biochem Biophys 298:395-402. 1992
    Oligomers and monomers of NADPH-cytochrome P450 reductase and cytochrome P450 LM2 (2B4) isolated from the liver microsomes of phenobarbital-treated rabbits were examined for physicochemical properties and catalytic activities...
  89. pmc NADPH oxidase limits innate immune responses in the lungs in mice
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 5:e9631. 2010
    Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent ..
  90. ncbi Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction
    Sachin A Gupte
    Departments of Physiology and Respiratory Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113, Japan
    Pulm Pharmacol Ther 19:303-9. 2006
    ..Although it has been suggested that changes in the NADPH/NADP+ ratio and redox status are involved in the mechanism of HPV, the role of PPP-derived NADPH in this ..
  91. ncbi Requirement of a compartmentalization for NADPH oxidizing site and peroxidase-H2O2 in the thyroid iodinating system
    N Ait Hammou
    INSERM-U. 96, , , France
    Horm Metab Res 19:606-8. 1987
    In this study, it is shown that NADPH iodination occurs in a thyroid peroxidase-H2O2 system in presence of thyroglobulin, the normal iodination substrate. Previous data suggested that thyroid H2O2 generation is a NADPH-dependent system...
  92. ncbi Inhibition of dihydrofolate reductase by mofebutazon
    E Strehl
    , , Bundesrepublik Deutschland
    Z Naturforsch C 48:815-7. 1993
    ..An apparent Ki for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron acceptor of approximately 0.2 mM was calculated.
  93. ncbi NADP-malic enzyme from the C4 plant Flaveria bidentis: nucleotide substrate specificity
    A R Ashton
    CSIRO Plant Industry, Canberra, Australia
    Arch Biochem Biophys 345:251-8. 1997
    ..The NAD-dependent activity is competitively inhibited by micromolar concentrations of NADP and NADPH (Ki approximately 2 microM)...
  94. ncbi Engineering and characterization of a NADPH-utilizing cytochrome b5 reductase
    Christopher C Marohnic
    Department of Biochemistry and Molecular Biology, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    Biochemistry 42:11170-82. 2003
    ..mutagenesis has been used to engineer the soluble rat cytochrome b(5) reductase diaphorase domain to utilize NADPH as the preferred electron donor...
  95. pmc Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo
    Thomas A Pedersen
    EMBL Mouse Biology Unit, Monterotondo, Italy
    EMBO J 26:1081-93. 2007
    ..dephosphorylated at S193 by insulin signaling, dysregulated genes involved in the generation of acetyl-CoA and NADPH for triglyceride synthesis and led to increased hepatic lipogenesis...
  96. pmc The chloroplast protein translocation complexes of Chlamydomonas reinhardtii: a bioinformatic comparison of Toc and Tic components in plants, green algae and red algae
    Ming Kalanon
    Plant Cell Biology Research Centre, School of Botany, University of Melbourne, Parkville, 3010 Victoria, Australia
    Genetics 179:95-112. 2008
    ..thaliana, with two exceptions. Missing from C. reinhardtii are the C-terminal ferredoxin-NADPH-reductase (FNR) binding domain of Tic62 and a full-length, TPR-bearing Toc64. Further, the N-terminal domain of C...
  97. doi Multi-mutational analysis of fifteen common mutations of the glucose 6-phosphate dehydrogenase gene in the Mediterrranean population
    Ma Esther Farez-Vidal
    Departamento de Bioquímica y Biología Molecular 3, Universidad de Granada, Spain
    Clin Chim Acta 395:94-8. 2008
    ..G6PD) is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defence against oxidizing agents and in reductive biosynthetic reactions...
  98. doi Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae
    Ashwani Kumar Vashishtha
    Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, Oklahoma 73019, USA
    Biochemistry 48:5899-907. 2009
    ..of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH to give saccharopine...
  99. ncbi Identification and isolation of an azoreductase from Enterococcus faecium
    Susan R Macwana
    Department of Microbiology and Molecular Genetics, Oklahoma State University, 418 LSE, Oklahoma State University Stillwater, OK 74075, USA
    Curr Issues Mol Biol 12:43-8. 2010
    ..AzoEf1 utilized both NADH and NADPH for the reduction of azo dyes, and it contains a leucyl residue at position 104 and threonyl residue at position ..
  100. doi Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia
    Q T Huang
    Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Placenta 34:949-52. 2013
    ..These effects could be inhibited by apocynin, an inhibitors of NADPH oxidase...
  101. doi NADPH oxidase 4 promotes cardiac microvascular angiogenesis after hypoxia/reoxygenation in vitro
    Jinyi Wang
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Free Radic Biol Med 69:278-88. 2014
    ..However, the roles of the various ROS sources remain unclear. This study sought to investigate the role of NADPH oxidase 4 (Nox4) in the cardiac microvascular endothelium in response to I/R injury...

Research Grants104 found, 100 shown here

  1. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..Activation of NADPH oxidase and uncoupled activity of endothelial nitric oxide synthase (eNOS) are sources of superoxide (O2[..
  2. Christopher S Wilcox; Fiscal Year: 2014
    ..We will test our hypothesis that PGVSMCs generate a "myocyte derived endothelial regulator factor" driven by NADPH oxidase that signals to adjacent ECs to reduce NO activity and prevent proliferation and angiogenesis via ADMA and/..
  3. Keer Sun; Fiscal Year: 2016
    ..b>NADPH oxidase 2 (NOX2) is an enzyme complex predominantly expressed by phagocytes...
  4. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2013
    ..neurovascular sympathetic transduction caused by Ang-II binding to angiotensin type 1 receptors (AT1R) activating NADPH oxidase or Xanthine oxidase (XO) to produce ROS...
  5. Role of Neuronal NOS in Neurotoxicity
    Stephen M Black; Fiscal Year: 2010
    ..We hypothesize that HI stimulates the activity of the NADPH oxidase complex, which in combination with the activity of superoxide dismutase generates hydrogen peroxide...
  6. Suresh C Tyagi; Fiscal Year: 2016
    ..chronic left ventricle (LV) volume overload causes mitochondrial oxidative stress (ROS and RNS) by inducing NADPH oxidase (p47 subunit), mtNOS and PAR-1, and H2S alleviates mitochondrial oxidative stress...
  7. Interactions Between Inflammation, Oxidant Stress and Cardiovascular Disease
    David G Harrison; Fiscal Year: 2013
    ..in intact plaques will be defined The role of DCs and T cells in promoting vascular smooth muscle death, NADPH oxidase expression and ROS production will be defined and a novel therapeutic approach to suppress tissue injury ..
  8. Mechanisms of Neuroprotection by Astrocytes in Alcohol Abuse
    James Haorah; Fiscal Year: 2012
    ..The statement is supported by our recent findings that activation of NADPH oxidase and inducible nitric oxide synthase by acetaldehyde increases the levels of reactive oxygen species and ..
  9. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ..line of host defense, killing invading microbes by generating reactive oxygen species (ROS) through an activatable NADPH oxidase system...
  10. ClC-3 Chloride Ion Channels in Vascular Smooth Muscle
    Fred Lamb; Fiscal Year: 2009
    ..Endosomal O2-" production by the Nox1 NADPH oxidase (originally termed the "mitogenic oxidase" because it is linked to growth and proliferation) requires both ..
  11. Role of NADPH oxidase 1-derived ROS in the pathogenesis of Parkinson's disease
    Yoon Seong Kim; Fiscal Year: 2012
    ..A family of NADPH oxidase (NOX) is the first enzyme complex discovered which is specialized to generate superoxide...
  12. Reactive Oxygen Species Signaling in the Hippocampus
    Eric Klann; Fiscal Year: 2012
    ..A[unreadable]-induced blockade of LTP requires reactive oxygen species (ROS) produced via mitochondria and/or NADPH oxidase, 2) determine whether A[unreadable] induces ROS-dependent increases in eIF2[unreadable] phosphorylation ..
  13. Mitochondria and Carcinogenesis
    Keshav K Singh; Fiscal Year: 2010
    ..to i) gross chromosomal rearrangements (GCR) 2) resistance to apoptosis 3) altered expression of ROS generating NADPH oxidase (Nox1) involved in tumorigenesis...
  14. Christopher S Wilcox; Fiscal Year: 2016
    ..enhances paraoxygenase-2 which activates a transcriptional redox-regulating pathways initiated by DJ2 to inhibit NADPH oxidase-induced ROS. These are supported by the Administrative, Animal and Bioanalytical Cores.
  15. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..These include eNOS, iNOS, guanylyl cyclase, protein kinase G, NADPH oxidase isoforms, Ca2+ channels, and SERCA...
  16. HUA LINDA CAI; Fiscal Year: 2016
    ..Aim 3: To determine whether netrin-1 inhibition of NADPH oxidase 4 (NOX4) and oxidative stress is mediated by CMEC-derived NO"...
  17. John F Keaney; Fiscal Year: 2016
    ..The NADPH oxidase (Nox) family of enzymes plays a prominent role in pathologic ROS production that limits NO7 bioactivity...
  18. PPAR gamma regulates vascular endothelial reactive species production in diabetes
    C Michael Hart; Fiscal Year: 2012
    ..Preliminary data indicate that PPARg activation decreases the enhanced expression and activity of NADPH oxidase in the vascular wall of diabetic animals and attenuates vascular dysfunction...
  19. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..Activation of ACE/Ang II/AT1 axis has been shown to induce overproduction of NADPH oxidase (NOX) derived ROS and reduction of eNOS derived NO...
  20. Nox 4 modulation of NO bioavailability and vascular function
    Siobhan E Craige; Fiscal Year: 2012
    ..Vascular ROS are produced by a number of enzymes, although the NADPH oxidase (Nox) family appears important for endothelial dysfunction...
  21. ENEIQUE A MESRI; Fiscal Year: 2016
    ..the Rac1 GTPase, a signaling mediator that triggers production of reactive oxygen species (ROS) by non-phagocytic NADPH-oxidase (NOX), as a potential major player in KS...
  22. Samantha M Yeligar; Fiscal Year: 2014
    ..In alveolar macrophages (AMs), NADPH oxidase (Nox) 1, Nox2, and Nox4 are critical sources of reactive oxygen species (ROS), and Nox2 is essential for ..
  23. Laura L Dugan; Fiscal Year: 2014
    ..through non-cannonical activation of the transcription factor, NFkB, induces neuronal expression and activation of NADPH oxidase (Nox2), a multimeric enzyme complex first described as the respiratory burst oxidase in neutrophils...
  24. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..wild type versus perR mutant bacteria will define PerR-dependent and independent GAS responses to ROS generated by NADPH oxidase and myeloperoxidase as well as other effector molecules of human neutrophil granules, and will exemplify ..
  25. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..ROS production results from the activation of the neutrophil NADPH superoxide complex...
  26. Karen Block; Fiscal Year: 2015
    ..Our preliminary data indicate that HG-mediated reduction of cellular ATP levels is associated with increased NADPH oxidase activity...
  27. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..by using mice we have made that allow us to delete either the extracellular superoxide dismutase (SOD3) or the NADPH oxidase subunit p22phox...
  28. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..that the ERK/STAT3/RANKL pathway is stimulated by reactive oxygen species (ROS) produced by an ethanol-induced NADPH oxidase (NOX4). Expression of this enzyme in osteoblasts is increased by EtOH and blocked by NAC...
  29. Mechanisms of Reperfusion-induced Endothelial Injury
    Cuihua Zhang; Fiscal Year: 2010
    ..propose that TNF-alpha will stimulate production of these chemical species by activation of xanthine oxidase and NADPH oxidase...
  30. Leonard P Rybak; Fiscal Year: 2016
    ..Cisplatin increases formation of reactive oxygen species (ROS) in the cochlea. A unique isoform of NADPH oxidase, NOX-3, is present in rat cochlea...
  31. Swapan K Nath; Fiscal Year: 2014
    ..hydrogen peroxide are key for defense against invading microbial pathogens, and are produced by the multi-protein NADPH- oxidase (NADPHO) system during phagocytosis...
  32. Toll-like receptor signaling in pathogenesis of pulmonary hypertension
    Yabing Chen; Fiscal Year: 2013
    ..NOX4 is the predominant NADPH oxidase in SMC that produce ROS...
  33. Gayle M Gordillo; Fiscal Year: 2014
    ..Nox-4 is the catalytic subunit of the enzyme NADPH oxidase that converts molecular oxygen to superoxide as the first step in endogenous reactive oxygen species ..
  34. Xiang Fang; Fiscal Year: 2015
    ..metabolism of endogenous ROS are disrupted in DM1, and determine whether the activity of the ROS producing enzyme NADPH oxidase is up- regulated in DM1 myoblasts and C2C12 cells expressing mutant CUG repeats;and 3) aim 3 will explore ..
  35. Reactive oxygen species in Ni(II) carcinogenesis
    Xianglin Shi; Fiscal Year: 2012
    ..We hypothesize that nickel (Ni3S2 and NiCl2) can stimulate the cells to activate NADPH oxidase via cdc42 and p47phox to produce superoxide radical, which is then converted to hydrogen peroxide and ..
  36. Alicia A McDonough; Fiscal Year: 2016
    ..We now show that NCCp increases with AngII treatment and decreases with high salt diet. AngII via AT1R stimulates NADPH oxidase (Nox), generating reactive oxygen species (ROS)...
  37. Spatial Control and Function of Nuclear Superoxide in LPS-mediated Cell Signaling
    NETANYA YEHUDIT SPENCER; Fiscal Year: 2013
    ..Our preliminary data indicate that nuclear NADPH oxidase isoform 4 (NOX4) is functionally distinct from the NOX4 complex found elsewhere in the cell...
  38. Mechanisms for Arsenic-Induced Vascular Disease
    Aaron Barchowsky; Fiscal Year: 2012
    ..short term cultures of murine or human LSEC are useful in revealing functional roles for As (III)-stimulated NADPH oxidase (NOX) generation of reactive oxygen species in the early signaling events affecting phenotype (e.g...
  39. Renu A Kowluru; Fiscal Year: 2015
    ..Emerging evidence implicates NADPH oxidase (Nox) also as a potential source of reactive oxygen species (ROS) with detrimental effects on cell ..
  40. Akira Sawa; Fiscal Year: 2015
    ..investigating possible cellular mechanisms underlying this susceptibility, such as the glutathione (GSH) cascade, NADPH oxidase, NAD/NADH, and mitochondrial functions...
  41. David G Harrison; Fiscal Year: 2016
    ..for aim 3, we have found that angiotensin II infusion increases dendritic cell superoxide production by the NADPH oxidase...
  42. Roy L Sutliff; Fiscal Year: 2016
    ..that chronic hypoxia and other causes of PH are associated with increased expression and activity of the NADPH oxidase, Nox4...
  43. Ozlem Yilmaz; Fiscal Year: 2016
    ..The eATP-induced ROS generation appears to be mediated by P2X7 receptor signaling coupled with NADPH oxidase and mitochondrial oxidative stress pathways...
  44. Matthew C Zimmerman; Fiscal Year: 2014
    ..generated by NADPH oxidase as important signaling intermediates in central neurons stimulated with AngII...
  45. Sheila E Crowe; Fiscal Year: 2015
    ..Our recent preliminary studies build on the understanding that ROS arises from activation of NADPH oxidase during H. pylori infection...
  46. Marschall S Runge; Fiscal Year: 2015
    ..provided by applicant): Extensive evidence from animal models and human studies supports the hypothesis that NADPH oxidase derived oxidative stress is a major contributor to the pathophysiology of cardiovascular diseases...
  47. James R Bamburg; Fiscal Year: 2014
    ..g., excitotoxic glutamate) or via a prion-dependent pathway, probably involving membrane NADPH oxidase (NOX) activation...
  48. Shilpa Vyas-Read; Fiscal Year: 2014
    ..T. Gauthier), NADPH oxidases (Dr. K. Griendling and Dr. M. Hart) and epithelial to mesenchymal transition (Dr. A.Stecenko)...
  49. Function of NADPH Oxidase(s) in T Lymphocytes
    Mark S Williams; Fiscal Year: 2010
    The family of NADPH oxidase enzymes serve to generate reactive oxygen species (ROS). The prototype, the phagocyte-type NADPH oxidase produces large amounts of ROS that serve a host defense role...
  50. MOLECULAR MECHANISMS OF LEUKOCYTE ACTIVATION
    Richard Ye; Fiscal Year: 2009
    ..In phagocytes, induced activation of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase leads to robust production of reactive oxygen species (ROS), which is essential for the elimination of ..
  51. Heme oxygenase and cerebral vascular injury
    Helena Parfenova; Fiscal Year: 2013
    ..indicate: 1) seizures increase production of reactive oxygen species (ROS) in the cerebral vasculature, and 2) NADPH oxidase and the mitochondrial respiratory chain are major sources of cerebrovascular oxidative stress caused by ..
  52. Richard D Ye; Fiscal Year: 2014
    ..In phagocytes, induced activation of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase leads to robust production of reactive oxygen species (ROS), which is essential for the elimination of ..
  53. Endothelial Generation of ROS in lung Ischemia
    Aron B Fisher; Fiscal Year: 2012
    ..and is characterized by endothelial cell membrane depolarization, activation of cell membrane associated NADPH oxidase (NOX2), generation of reactive oxygen species (ROS), activation of transcription factors (NF(B, AP-1, and ..
  54. Role of NADPH oxidase in insulin resistance
    Amina El Jamali; Fiscal Year: 2013
    ..b>NADPH oxidases (NOX) are important sources of ROS and are identified as pathogenic factors in a number of disease states,..
  55. Endothelial Dysfunction in Insulin Resistance
    David W Busija; Fiscal Year: 2010
    ..dysfunction of the cerebral circulation in IR is due to augmented ROS levels from enhanced activity of the NADPH oxidase system...
  56. Aron B Fisher; Fiscal Year: 2015
    ..provided by applicant): The goal of this proposal is to evaluate a novel role for Prdx6 in the activation of NADPH oxidase (NOX2)...
  57. Christopher V Carman; Fiscal Year: 2014
    ..Then in similar settings we will determine the role for Rac1-associated NADPH oxidase signaling (e.g., p47phox) in micro-wound closure and its sensitivity to perturbation by oxidative stress...
  58. T cell-mediated lung ischemia-reperfusion injury
    Victor E Laubach; Fiscal Year: 2013
    ..Oxidative stress and the release of reactive oxygen species via NADPH oxidase is also a component of IR injury as well as phagocytic cell activation...
  59. Eng H Lo; Fiscal Year: 2015
    ..We will use brain endothelial cell cultures to test the hypothesis that SDF-1 triggers an NADPH oxidase (Nox) mechanism that upregulates endogenous ROS...
  60. Protein radicals in microglia: environmental mechanisms of chronic neurotoxicity
    Michelle L Block; Fiscal Year: 2013
    ..Microglial NADPH oxidase and reactive oxygen species have been strongly been implicated as key elements of toxic microglial ..
  61. Raghu Vemuganti; Fiscal Year: 2014
    ..We will test apocynin that inhibits NADPH oxidase subunit NOX2 and thus curtails reactive oxygen species (ROS) formation, and TBHQ that potentiates the ..
  62. Tsung Ung W Woo; Fiscal Year: 2014
    ..technique to examine two enzymes that promote oxidative stress, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) and neuronal nitric oxide synthase (nNOS), and the catalytic and modulatory subunits of the ..
  63. Vickram Ramkumar; Fiscal Year: 2016
    ..We and others have shown that the NOX3 isoform of NADPH oxidase is the primary source of ROS in the cochlea which is activated by cisplatin...
  64. John R Hoidal; Fiscal Year: 2016
    ..We hypothesize that RAGE and its ligands through distinct signaling pathways that include NADPH oxidase(s) (Nox)-generated reactive oxygen species (ROS) activate key transcription factors including NF-B and EGR-..
  65. Redox Triggering of Glomerular NALP3 Inflammasomes in Hyperhomocysteinemia
    Justine M Abais; Fiscal Year: 2013
    ..This grant proposal hypothesizes that elevated extracellular Hcys concentrations activate NADPH oxidase (Nox) to produce reactive oxygen species (ROS) and thereby activate NALP3 inflammasomes in podocytes and ..
  66. Mechanisms of Early Life Stress-Induced Endothelial Dysfunction
    Dao Ho; Fiscal Year: 2013
    ..adult MSEW mice have endothelial dysfunction in conduit arteries that is dependent on reactive oxygen species and NADPH oxidase...
  67. Ke Jian Liu; Fiscal Year: 2016
    ..In Aim 1 we will investigate the impact of arsenic-mediated iNOS and NADPH oxidase (NOX) induction and subsequent nitric oxide and superoxide generation on the activity of two DNA repair ..
  68. JEFFREY BENTON HODGIN; Fiscal Year: 2014
    ..Rac1 is important for the activation of NADPH oxidase in nonphagocytic cells and Cdc42 appears to inhibit the generation of reactive oxygen species (ROS) by ..
  69. STUDY OF DIABETIC RETINOPATHY
    Timothy S Kern; Fiscal Year: 2013
    ..cells kill retinal cells in diabetes, focusing initially on the role of reactive oxygen species generated by NADPH oxidase in the development of diabetes-induced inflammation...
  70. Cell Models for Alzheimer's disease (AD): Lipids and Related Signaling Pathways
    Grace Y Sun; Fiscal Year: 2012
    ..will test the hypotheses that: (1) progression of AD involves expression and activation of the cPLA?/sPLA2/NADPH oxidase pathways to induce inflammatory responses in glial cells and impairment of neuronal functions;(2) chronic ..
  71. Gabor Csanyi; Fiscal Year: 2014
    ..objectives: 1) to acquire additional scientific training in skills ad knowledge;2) to merge the yet distinct NADPH oxidase (Nox) and TSP1 fields with the goals toward opening up new avenues of discovery and establishing Dr...
  72. Targeting Tumor Cell Iron Addiction to Achieve Tumor-Selective Cell Death
    Scott Dixon; Fiscal Year: 2013
    ..proliferation and for the lethal effects of erastin, via regulation of cytosolic iron levels and heme-dependent NADPH oxidase 1 (NOX1) complex activity...
  73. Lee Ann H Allen; Fiscal Year: 2016
    ..tularensis to act at multiple levels to disrupt NADPH oxidase assembly and activity, and identified relevant virulence factors. We were also the first to show that F...
  74. Saurabh Chatterjee; Fiscal Year: 2014
    ..The specific aims will be achieved by using inhibitors of enzymes such as NADPH oxidase and the Cyp450 isozyme CYP2E1 and with knockout mice lacking each of these enzymes...
  75. Ann Richmond; Fiscal Year: 2016
    ..The entrainment process is thought to require activation of neutrophil NADPH oxidase to ultimately generate extracellular H2O2, which is toxic to tumor cells...
  76. Raymond A Swanson; Fiscal Year: 2016
    ..dysfunction, but recent studies show that the superoxide is instead produced by the signaling enzyme, NADPH oxidase...
  77. NADPH OXIDASE REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN SEPSIS
    John W Christman; Fiscal Year: 2013
    ..We have shown that inhibition of NADPH oxidase activity results in dampening of the transcription nuclear factor kappa B (NF-[unreadable]B) activation in ..
  78. Elevated Zinc in Ischemia and reperfusion
    Yang V Li; Fiscal Year: 2013
    ..and subsequently aggravate Zn2+ accumulation;the elevated Zn2+ then amplifies ROS production, by activating NADPH oxidase, in reperfusion...
  79. Eric Pearlman; Fiscal Year: 2016
    ..chemokine production in the cornea leading to recruitment of PMN-17 cells, and Aim 3 will examine IL-17 induced NADPH oxidase and kynurenine mediated ROS production by PMN-17 cells...
  80. SHERRY L ABBOUD-WERNER; Fiscal Year: 2016
    ..show osteopetrosis with increased fractures and osteocyte defects including apoptosis, associated with increased NADPH oxidase Nox4 expression/activity and reduced Cx43 expression...
  81. Timothy S Kern; Fiscal Year: 2016
    ..Aim 3 will be tested using mice having (i) photoreceptor-specific knockdown of NADPH oxidase (and for comparison, (ii) systemic inhibition of NADPH oxidase), and (iii) far-red light therapy...
  82. Arjang Djamali; Fiscal Year: 2015
    ..Nox2 is the classical phagocytic isoform of the NADPH oxidase enzyme responsible for "oxidative burst", the mechanism that eliminates internalized pathogens...
  83. Victor J Thannickal; Fiscal Year: 2016
    ..pathways are controlled by the anti-fibrotic micro-RNA, miR-31, and the pro-fibrotic oxidant-generating enzyme, NADPH oxidase-4 (NOX4)...
  84. Albert van Der Vliet; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The NADPH oxidase DUOX1 is prominently expressed within the respiratory epithelium and has been invoked in innate airway epithelial responses to injury or infectious stimuli, by promoting H2O2-..
  85. Nadim James Hallab; Fiscal Year: 2016
    ..e. from initial lysosomal destabilization and NADPH oxidase induction of ROS, to NALP3-ASC oligomerization, and Caspase 1 conversion of pro-IL-1 to IL-1...
  86. Elia J Duh; Fiscal Year: 2015
    ..of ischemic retina, regulating oxidative stress and pro- inflammatory changes in the retina via modulation of NADPH oxidase. We propose the following 3 aims: Specific Aim 1...
  87. Regulation of NADPH Oxidase by Angiotensin II-Role in Myometrial Hypertrophy
    Xiaolan Cui; Fiscal Year: 2007
    ..b>NADPH oxidase isoforms, via generation of reactive oxygen species, have been shown to be responsible for the growth ..
  88. Asrar B Malik; Fiscal Year: 2016
    ..Asrar Malik, P.I., and colleagues will address the concept that cross-talk between PMNs and ECs via NADPH oxidase-derived oxidants is critical in signaling the gating of the novel, oxidant-sensitive transient receptor ..
  89. Dennis B Lubahn; Fiscal Year: 2014
    ..The 5 key pathways to be examined are the (anti)oxidant (Nrf2/Keap1 and NADPH oxidase) pathways and their interactions with the NF-kappaB-, estrogen-, and hedgehog-signaling pathways...
  90. William R Tyor; Fiscal Year: 2016
    ..MP-specific ribonucleoside chain terminators and their phosphate prodrugs for increased delivery to the CNS, and NADPH oxidase inhibitors that are known to cross the BBB which indirectly could reduce NF8[unreadable]- dependent HIV-1 ..
  91. SHERRY ADESINA; Fiscal Year: 2014
    ..Current evidence suggests that reactive oxygen species (ROS) generated by both mitochondrial respiration and NADPH oxidase activity may play a role in vascular cell proliferation, right ventricular hypertrophy, and PH ..
  92. PHILIPP MICHAEL NIETHAMMER; Fiscal Year: 2016
    ..Using the zebrafish tail fin wounding assay, we recently found that the epithelial NADPH oxidase DUOX generates a gradient of hydrogen peroxide (H2O2) that extends up to ~200 um from the wound margin ..
  93. Apple peel extract inhibits Cr(VI)-induced lung cancer
    Zhuo Zhang; Fiscal Year: 2013
    ..Two approaches will be used: (a) to investigate the chelation of Cr(V)-NADPH complex or change of its structure by apple peel extract;and (b) to investigate the inhibition of apple peel ..
  94. 2013 Phagocytes Gordon Research Conference and Seminar
    Lee Ann H Allen; Fiscal Year: 2013
    ..structure and function, such as elucidation of the composition of neutrophil granules, and discovery of the NADPH oxidase, the 2013 Phagocytes GRC will be a forum for high-quality presentations and in depth discussions of the ..
  95. Nox1 and Nox4 in Neuronal Apoptosis
    STEVEN TAMMARIELLO; Fiscal Year: 2007
    ..b>NADPH oxidase is an enzyme known to produce significant ROS levels in non-neuronal cell types...
  96. Allen W Cowley; Fiscal Year: 2016
    ..resulting in excess production of H202 in SS rats as amplified by a greater expression of the p67phox subunit of NADPH oxidase...
  97. REGULATION OF SUPEROXIDE PRODUCTION BY HUMAN NEUTROPHILS
    Jeffrey Friedman; Fiscal Year: 2007
    The superoxide-generating NADPH oxidase is a complex, multicomponent system that is present in a dormant form in unstimulated neutrophils, but is activated after exposure of the cells to a wide range of stimuli...
  98. Rac, Superoxide and Antioxidants in Hypertension
    Pascal Goldschmidt Clermont; Fiscal Year: 2005
    ..The NADPH oxidase system of vascular cells, whose central component is Nox1, is the major source of ROS in vascular tissues...
  99. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    ..Furthermore, oxygen fluctuations activate EC NADPH oxidase to release reactive oxygen species that trigger apoptosis of ECs and endothelial precursor cells ..
  100. CNS INJURY AND EDEMA RESEARCH CENTER
    Pak Chan; Fiscal Year: 2007
    ..Our working hypothesis is that NADPH oxidase, a pro-oxidant enzyme that localizes in all the cells of the neurovascular unit, initiates oxidative ..
  101. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
    ..Preliminary data from NADPH oxidase knockout mice indicate that protons cross the apical membranes of taste cells through two hydrogen ion ..