decorin

Summary

Gene Symbol: decorin
Description: decorin
Alias: CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B, decorin, bone proteoglycan II, dermatan sulphate proteoglycans II, proteoglycan core protein, small leucine-rich protein 1B
Species: human
Products:     decorin

Top Publications

  1. Augoff K, Rabczynski J, Tabola R, Czapla L, Ratajczak K, Grabowski K. Immunohistochemical study of decorin expression in polyps and carcinomas of the colon. Med Sci Monit. 2008;14:CR530-5 pubmed
    Recent studies showed that a small leucine-rich proteoglycan, decorin, may suppress tumor progression as a natural anticancer agent negatively controlling cellular growth...
  2. Salomäki H, Sainio A, Söderström M, Pakkanen S, Laine J, Järveläinen H. Differential expression of decorin by human malignant and benign vascular tumors. J Histochem Cytochem. 2008;56:639-46 pubmed publisher
    An increasing amount of evidence indicates that a small extracellular chondroitin/dermatan sulfate proteoglycan, decorin, is indirectly involved in angiogenesis...
  3. Fisher L, Termine J, Young M. Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. J Biol Chem. 1989;264:4571-6 pubmed
    ..sequenced and found to be identical with the PG II class of proteoglycan from human fibroblasts known as PG-40 or decorin. The clones reacting to the PG I antisera, however, had a unique sequence...
  4. Krusius T, Ruoslahti E. Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA. Proc Natl Acad Sci U S A. 1986;83:7683-7 pubmed
    ..Availability of the cloned cDNA for the proteoglycan now makes it possible to apply methods of molecular biology to study the collagen-binding and cell attachment-inhibiting properties of this proteoglycan. ..
  5. Scholzen T, Solursh M, Suzuki S, Reiter R, Morgan J, Buchberg A, et al. The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. J Biol Chem. 1994;269:28270-81 pubmed
    b>Decorin, a proteoglycan known to interact with collagen and growth factors, may play key roles during ontogenesis, tissue remodeling, and cancer...
  6. Honda E, Munakata H. Purification and characterization of decorin from the culture media of MRC-5 cells. Int J Biochem Cell Biol. 2004;36:1635-44 pubmed
    ..Myofibroblasts secrete several components of the extracellular matrix, including decorin. To clarify the properties of decorin synthesized by myofibroblasts, we have purified and characterized decorin ..
  7. Imai K, Hiramatsu A, Fukushima D, Pierschbacher M, Okada Y. Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release. Biochem J. 1997;322 ( Pt 3):809-14 pubmed
    b>Decorin (DCN) is a ubiquitous proteoglycan comprised of a core protein attached to a single dermatan/chondroitin sulphate glycosaminoglycan chain...
  8. Kalamajski S, Aspberg A, Lindblom K, Heinegard D, Oldberg A. Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization. Biochem J. 2009;423:53-9 pubmed publisher
    ..This binding is inhibited by recombinant asporin fragment LRR (leucine-rich repeat) 10-12 and by full-length decorin, but not by biglycan...
  9. Oda G, Sato T, Ishikawa T, Kawachi H, Nakagawa T, Kuwayama T, et al. Significance of stromal decorin expression during the progression of breast cancer. Oncol Rep. 2012;28:2003-8 pubmed publisher
    b>Decorin, a small leucine-rich proteoglycan and important component of the extracellular matrix (ECM), is a natural anticancer agent that modulates several receptors involved in cell growth and survival...

More Information

Publications72

  1. Buraschi S, Neill T, Goyal A, Poluzzi C, Smythies J, Owens R, et al. Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci U S A. 2013;110:E2582-91 pubmed publisher
    Soluble decorin affects the biology of several receptor tyrosine kinases by triggering receptor internalization and degradation...
  2. Zafiropoulos A, Nikitovic D, Katonis P, Tsatsakis A, Karamanos N, Tzanakakis G. Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells. Mol Cancer Res. 2008;6:785-94 pubmed publisher
    b>Decorin is an established natural oncosuppressive factor whose action is being studied in detail. Recently, decorin gene therapy formulations using adenoviral vectors have been shown in several animal models with very promising results...
  3. Li X, Pennisi A, Yaccoby S. Role of decorin in the antimyeloma effects of osteoblasts. Blood. 2008;112:159-68 pubmed publisher
    ..bone formation have a negative impact on myeloma cell growth in a subset of patients, we investigated the role of decorin, the main small leucine-rich proteoglycan (SLRP) expressed and produced by osteoblasts, in the antimyeloma ..
  4. Buraschi S, Neill T, Owens R, Iniguez L, Purkins G, Vadigepalli R, et al. Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model. PLoS ONE. 2012;7:e45559 pubmed publisher
    b>Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple receptor tyrosine kinases, such ..
  5. Goldoni S, Owens R, McQuillan D, Shriver Z, Sasisekharan R, Birk D, et al. Biologically active decorin is a monomer in solution. J Biol Chem. 2004;279:6606-12 pubmed
    It has been reported that decorin and its protein core can have molecular masses nearly double the size of those previously published, suggesting a dimeric structure...
  6. Buraschi S, Pal N, Tyler Rubinstein N, Owens R, Neill T, Iozzo R. Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels. J Biol Chem. 2010;285:42075-85 pubmed publisher
    ..b>Decorin binds and down-regulates several RTKs, including Met, the receptor for hepatocyte growth factor...
  7. Guidetti G, Bertoni A, Viola M, Tira E, Balduini C, Torti M. The small proteoglycan decorin supports adhesion and activation of human platelets. Blood. 2002;100:1707-14 pubmed
    b>Decorin is a small leucine-rich proteoglycan able to interact with several molecules of the subendothelial matrix, such as collagen and fibronectin...
  8. Dil N, Banerjee A. A role for aberrantly expressed nuclear localized decorin in migration and invasion of dysplastic and malignant oral epithelial cells. Head Neck Oncol. 2011;3:44 pubmed publisher
    ..Death usually occurs as a result of local invasion and regional lymph node metastases. Decorin is a multifunctional proteoglycan of the extracellular matrix that affects the biology of various types of cancer...
  9. Fleischmajer R, Fisher L, MacDonald E, Jacobs L, Perlish J, Termine J. Decorin interacts with fibrillar collagen of embryonic and adult human skin. J Struct Biol. 1991;106:82-90 pubmed
    Biglycan (PG-I, BGN) and decorin (PG-II, DCN) are small proteoglycans that have been isolated in cartilage, skin, and bone...
  10. Stander M, Naumann U, Wick W, Weller M. Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. Cell Tissue Res. 1999;296:221-7 pubmed
    b>Decorin is a member of the small leucine-rich proteoglycan (SLRP) gene family that has recently become a focus in various areas of cancer research...
  11. Yamaguchi Y, Mann D, Ruoslahti E. Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature. 1990;346:281-4 pubmed
    b>Decorin is a small chondroitin-dermatan sulphate proteoglycan consisting of a core protein and a single glycosaminoglycan chain. Eighty per cent of the core protein consists of 10 repeats of a leucin-rich sequence of 24 amino acids...
  12. Danielson K, Fazzio A, Cohen I, Cannizzaro L, Eichstetter I, Iozzo R. The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. Genomics. 1993;15:146-60 pubmed
    b>Decorin is a chondroitin/dermatan sulfate proteoglycan expressed by most vascular and avascular connective tissues and, because of its ability to interact with collagen and growth factors, has been implicated in the control of matrix ..
  13. Cawthorn T, Moreno J, Dharsee M, Tran Thanh D, Ackloo S, Zhu P, et al. Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival. PLoS ONE. 2012;7:e30992 pubmed publisher
    ..These analyses identified decorin (DCN) and endoplasmin (HSP90B1) which play important roles regulating the tumour microenvironment and in pathways ..
  14. Augoff K, Grabowski K, Rabczynski J, Kolondra A, Tabola R, Sikorski A. Expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity. Cancer Invest. 2009;27:443-52 pubmed publisher
    To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus...
  15. Boivin W, Shackleford M, Vanden Hoek A, Zhao H, Hackett T, Knight D, et al. Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-?1. PLoS ONE. 2012;7:e33163 pubmed publisher
    ..Three extracellular GrB PG substrates were identified; decorin, biglycan and betaglycan...
  16. Fiedler L, Schonherr E, Waddington R, Niland S, Seidler D, Aeschlimann D, et al. Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity. J Biol Chem. 2008;283:17406-15 pubmed publisher
    The proteoglycan decorin is expressed by sprouting but not quiescent endothelial cells, and angiogenesis is dysregulated in its absence...
  17. Rühland C, Schonherr E, Robenek H, Hansen U, Iozzo R, Bruckner P, et al. The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis. FEBS J. 2007;274:4246-55 pubmed
    b>Decorin is a multifunctional small leucine-rich proteoglycan involved in the regulation of collagen fibrillogenesis...
  18. Lochner K, Gaemlich A, Südel K, Venzke K, Moll I, Knott A, et al. Expression of decorin and collagens I and III in different layers of human skin in vivo: a laser capture microdissection study. Biogerontology. 2007;8:269-82 pubmed
    ..For the regulation of collagen fiber diameter, the proteoglycan decorin appears to be of major relevance...
  19. Seidler D, Goldoni S, Agnew C, Cardi C, Thakur M, Owens R, et al. Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation. J Biol Chem. 2006;281:26408-18 pubmed
    b>Decorin is not only a regulator of matrix assembly but also a key signaling molecule that modulates the activity of tyrosine kinase receptors such as the epidermal growth factor receptor (EGFR)...
  20. Skandalis S, Labropoulou V, Ravazoula P, Likaki Karatza E, Dobra K, Kalofonos H, et al. Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas. BMC Cancer. 2011;11:314 pubmed publisher
    ..Matrix proteoglycans versican and decorin are frequently over-expressed in various malignancies and are differently involved in the progression of cancer...
  21. Goldoni S, Humphries A, Nyström A, Sattar S, Owens R, McQuillan D, et al. Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol. 2009;185:743-54 pubmed publisher
    b>Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell growth by down-regulating the epidermal growth factor receptor...
  22. Hildebrand A, Romaris M, Rasmussen L, Heinegard D, Twardzik D, Border W, et al. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J. 1994;302 ( Pt 2):527-34 pubmed
    We have analysed the interactions of three proteoglycans of the decorin family, decorin, biglycan and fibromodulin, with transforming growth factor beta (TGF-beta)...
  23. Iozzo R, Moscatello D, McQuillan D, Eichstetter I. Decorin is a biological ligand for the epidermal growth factor receptor. J Biol Chem. 1999;274:4489-92 pubmed
    Ectopic expression of decorin induces profound cytostatic effects in transformed cells with diverse histogenetic backgrounds. The mechanism of action has only recently begun to be elucidated...
  24. Kelemen L, Couch F, Ahmed S, Dunning A, Pharoah P, Easton D, et al. Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies. Breast Cancer Res. 2008;10:R98 pubmed publisher
    ..supportive framework of biologic tissue in the breast, consisting of various proteins such as the proteoglycans, decorin and lumican. Altered expression of decorin and lumican is associated with breast tumors...
  25. Bi X, Pohl N, Qian Z, Yang G, Gou Y, Guzman G, et al. Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice. Carcinogenesis. 2012;33:326-30 pubmed publisher
    Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting ..
  26. Rødahl E, Van Ginderdeuren R, Knappskog P, Bredrup C, Boman H. A second decorin frame shift mutation in a family with congenital stromal corneal dystrophy. Am J Ophthalmol. 2006;142:520-1 pubmed
    ..of polymerase chain reaction (PCR) products generated from amplification of exons and adjacent introns of the decorin gene. The family consisted of a mother and her son, both suffering from congenital stromal corneal dystrophy...
  27. Biaoxue R, Xiguang C, Hua L, Hui M, Shuanying Y, Wei Z, et al. Decreased expression of decorin and p57(KIP2) correlates with poor survival and lymphatic metastasis in lung cancer patients. Int J Biol Markers. 2011;26:9-21 pubmed
    b>Decorin, p57(KIP2), and TGF-beta 1 have been investigated as prognostic factors because they appear to be associated with tumorigenesis; however, the effect of decorin and p57(KIP2) in lung cancer remains poorly understood...
  28. Melrose J, Fuller E, Roughley P, Smith M, Kerr B, Hughes C, et al. Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Res Ther. 2008;10:R79 pubmed publisher
    ..There was little fragmentation of SLRPs in normal control knee articular cartilage. Only decorin exhibited a consistent increase in fragmentation in menisci in association with osteoarthritis...
  29. Yamaguchi Y, Ruoslahti E. Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation. Nature. 1988;336:244-6 pubmed
    In studying the functional role of an extracellular matrix proteoglycan, decorin, we have made observations that suggest a role for this proteoglycan in the control of cell proliferation...
  30. Zhu J, Goldoni S, Bix G, Owens R, McQuillan D, Reed C, et al. Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. J Biol Chem. 2005;280:32468-79 pubmed
    b>Decorin inhibits the epidermal growth factor receptor (EGFR) by down-regulating its tyrosine kinase activity, thereby blocking the growth of a variety of transformed cells and tumor xenografts...
  31. Bredrup C, Knappskog P, Majewski J, Rødahl E, Boman H. Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene. Invest Ophthalmol Vis Sci. 2005;46:420-6 pubmed
    ..To describe the clinical and pathologic characteristics of a family with a congenital stromal dystrophy of the cornea and to identify the genetic basis for this disorder...
  32. Al Haj Zen A, Lafont A, Durand E, Brasselet C, Lemarchand P, Godeau G, et al. Effect of adenovirus-mediated overexpression of decorin on metalloproteinases, tissue inhibitors of metalloproteinases and cytokines secretion by human gingival fibroblasts. Matrix Biol. 2003;22:251-8 pubmed
    b>Decorin is a small leucine-rich proteoglycan that plays a role in control of cell proliferation, cell migration, collagen fibrillogenesis and modulation of the activity of TGF-beta...
  33. Chen S, Sun M, Iozzo R, Kao W, Birk D. Intracellularly-retained decorin lacking the C-terminal ear repeat causes ER stress: a cell-based etiological mechanism for congenital stromal corneal dystrophy. Am J Pathol. 2013;183:247-56 pubmed publisher
    b>Decorin, a small leucine-rich proteoglycan (SLRP), is involved in the pathophysiology of human congenital stromal corneal dystrophy (CSCD). This disease is characterized by corneal opacities and vision impairment...
  34. Santra M, Reed C, Iozzo R. Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. J Biol Chem. 2002;277:35671-81 pubmed
    b>Decorin, a small leucine-rich proteoglycan, is a key regulator of tumor growth by acting as an antagonist of the epidermal growth factor receptor (EGFR) tyrosine kinase...
  35. Winnemöller M, Schon P, Vischer P, Kresse H. Interactions between thrombospondin and the small proteoglycan decorin: interference with cell attachment. Eur J Cell Biol. 1992;59:47-55 pubmed
    b>Decorin, a ubiquitous small interstitial dermatan sulfate proteoglycan, interacts with several extracellular matrix components, e.g., with type I collagen and fibronectin...
  36. Iozzo R, Buraschi S, Genua M, Xu S, Solomides C, Peiper S, et al. Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling. J Biol Chem. 2011;286:34712-21 pubmed publisher
    ..The proteoglycan decorin, a key component of the tumor stroma, can positively regulate the IGF-IR system in normal cells...
  37. Benet M, Dulman R, Suzme R, de Miera E, Vega M, Nguyen T, et al. Wild type N-ras displays anti-malignant properties, in part by downregulating decorin. J Cell Physiol. 2012;227:2341-51 pubmed publisher
    ..Through mRNA and microRNA (miRNAs) expression profiling we have identified genes (decorin) and miRNAs (mir-29A, let-7b) modulated by wt N-ras potentially responsible for the anti-malignant effect...
  38. Neill T, Schaefer L, Iozzo R. Decorin: a guardian from the matrix. Am J Pathol. 2012;181:380-7 pubmed publisher
    b>Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the ..
  39. Boström P, Sainio A, Kakko T, Savontaus M, Söderström M, Jarvelainen H. Localization of decorin gene expression in normal human breast tissue and in benign and malignant tumors of the human breast. Histochem Cell Biol. 2013;139:161-71 pubmed publisher
    The small extracellular matrix proteoglycan decorin which possesses a potent antitumor activity has been shown to be present in various amounts in the stroma of several tumors including those of the breast...
  40. Araki K, Wakabayashi H, Shintani K, Morikawa J, Matsumine A, Kusuzaki K, et al. Decorin suppresses bone metastasis in a breast cancer cell line. Oncology. 2009;77:92-9 pubmed publisher
    b>Decorin, the prototype of an expanding family of small leucine-rich proteoglycans, is involved in a number of cellular processes including matrix assembly, fibrillogenesis and the control of cell proliferation...
  41. Banerjee A, Bhattacharyya I, Lydiatt W, Vishwanatha J. Aberrant expression and localization of decorin in human oral dysplasia and squamous cell carcinoma. Cancer Res. 2003;63:7769-76 pubmed
    The small leucine-rich proteoglycan decorin has been associated with negative regulation of cell growth...
  42. Feugaing D, Tammi R, Echtermeyer F, Stenmark H, Kresse H, Smollich M, et al. Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling. Biochimie. 2007;89:637-57 pubmed
    Human skin fibroblasts efficiently internalize the matrikine decorin by receptor-mediated endocytosis, however, very little is known about its intracellular trafficking routes up to lysosomal degradation...
  43. Abbah S, Thomas D, Browne S, O BRIEN T, Pandit A, Zeugolis D. Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture. Sci Rep. 2016;6:20922 pubmed publisher
    ..In tendon tissue repair, increased activity of TGF-β1 leads to progressive fibrosis. Decorin (DCN) and interleukin 10 (IL-10) antagonise pathological collagen synthesis by exerting a neutralising effect via ..
  44. Yang Q, Wang S, Wang Y, Qu Y, Xue J, Mi Y, et al. Decorin-loaded poly lactic-co-glycolic acid nanoparticles modified by anti-alpha fetoprotein antibody: preparation, proliferation inhibition and induced apoptosis effects on HepG2 cells in vitro. J Pharm Pharmacol. 2017;69:633-641 pubmed publisher
    b>Decorin (DCN) is a negative regulatory factor for the growth of cancer cells and can inhibit the proliferation, metastasis of cancer cells and angiogenesis in cancer tissues...
  45. Boström P, Sainio A, Eigėlienė N, Jokilammi A, Elenius K, Koskivuo I, et al. Human Metaplastic Breast Carcinoma and Decorin. Cancer Microenviron. 2017;10:39-48 pubmed publisher
    ..However, little is known about the composition of the ECM and its constituents in MBC. Decorin is a ubiquitous ECM macromolecule known of its oncosuppressive activity...
  46. Bhattacharya S, Khan M, Ghosh C, Bank S, Maiti S. The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes. Sci Rep. 2017;7:8252 pubmed publisher
    ..It can be concluded that stress-induced decrease in insulin synthesis/function, glucose transport is an interactive consequence of oxidative threats and inflammatory events. ..
  47. Aldave A, Rosenwasser G, Yellore V, Papp J, Sobel E, Pham M, et al. Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC. Invest Ophthalmol Vis Sci. 2010;51:4006-12 pubmed publisher
    ..Linkage and haplotype analyses identified 12q21.33 as a locus for PACD. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region. ..
  48. Abdel Wahab N, Wicks S, Mason R, Chantry A. Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240. Biochem J. 2002;362:643-9 pubmed
    ..Naturally occurring inhibitors of this TGFbeta-dependent fibrotic response include decorin, a small leucine-rich proteoglycan...
  49. Muñoz A, Muñoz M, González A, ten Donkelaar H. Organization of the caudal rhombencephalic alar plate of the ribbed newt Pleurodeles waltl: evidence for the presence of dorsal column and lateral cervical nuclei. Brain Behav Evol. 1998;51:162-82 pubmed
    ..These data show that even in the poorly segregated caudal rhombencephalic alar plate of urodeles a DCN and LCN can be distinguished with afferent and efferent projections comparable to those in anurans and other terrestrial vertebrates. ..
  50. Dale T, Mazher S, Webb W, Zhou J, Maffulli N, Chen G, et al. Tenogenic Differentiation of Human Embryonic Stem Cells. Tissue Eng Part A. 2017;: pubmed publisher
    ..The directed in vitro generation of tenocytes from pluripotent stem cells may facilitate the development of novel repair approaches for this difficult to heal tissue...
  51. Iwafune M, Kakizaki I, Yukawa M, Kudo D, Ota S, Endo M, et al. Reconstruction of glycosaminoglycan chains in decorin. Biochem Biophys Res Commun. 2002;297:1167-70 pubmed
    The glycosaminoglycan chain of decorin from human spinal ligaments was digested using the hydrolysis of bovine testicular hyaluronidase...
  52. Gao Y, Manzoor N, Kaltenbach J. Evidence of activity-dependent plasticity in the dorsal cochlear nucleus, in vivo, induced by brief sound exposure. Hear Res. 2016;341:31-42 pubmed publisher
  53. Wen J, Xiao J, Rahdar M, Choudhury B, Cui J, Taylor G, et al. Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc Natl Acad Sci U S A. 2014;111:15723-8 pubmed publisher
    ..Collectively, our findings suggest that GalT-II function is impaired by loss of Fam20B-dependent xylose phosphorylation and reveal a previously unappreciated mechanism for regulation of proteoglycan biosynthesis. ..
  54. Trask B, Trask T, Broekelmann T, Mecham R. The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin. Mol Biol Cell. 2000;11:1499-507 pubmed
    ..microfibrils, were shown by immunoprecipitation studies to interact with the chondroitin sulfate proteoglycan decorin in the medium of cultured fetal bovine chondrocytes...
  55. Järveläinen H, Sainio A, Wight T. Pivotal role for decorin in angiogenesis. Matrix Biol. 2015;43:15-26 pubmed publisher
    ..review we have focused on the role and potential mechanisms of a multifunctional small leucine-rich proteoglycan decorin in angiogenesis...
  56. Kasamatsu A, Uzawa K, Minakawa Y, Ishige S, Kasama H, Endo Sakamoto Y, et al. Decorin in human oral cancer: a promising predictive biomarker of S-1 neoadjuvant chemosensitivity. Biochem Biophys Res Commun. 2015;457:71-6 pubmed publisher
    We reported previously that decorin (DCN) is significantly up-regulated in chemoresistant cancer cell lines. DCN is a small leucine-rich proteoglycan that exists and functions in stromal and epithelial cells...
  57. El Behi M, Krumeich S, Lodillinsky C, Kamoun A, Tibaldi L, Sugano G, et al. An essential role for decorin in bladder cancer invasiveness. EMBO Mol Med. 2013;5:1835-51 pubmed publisher
    ..a parallel mechanism developed by MB49-I to subvert its environment: de novo secretion of the proteoglycan decorin. We show that decorin overexpression in the MB49/MB49-I model is required for efficient progression, by promoting ..
  58. Borbely A, Daher S, Ishigai M, Mattar R, Sun S, Knöfler M, et al. Decorin and biglycan immunolocalization in non-villous structures of healthy and pathological human placentas. Histopathology. 2014;64:616-25 pubmed publisher
    b>Decorin and biglycan are members of the small leucine-rich proteoglycan family, and constituents of both the extracellular matrix (ECM) and the cell surface...
  59. Nadesalingam J, Bernal A, Dodds A, Willis A, Mahoney D, Day A, et al. Identification and characterization of a novel interaction between pulmonary surfactant protein D and decorin. J Biol Chem. 2003;278:25678-87 pubmed
    ..Here we describe the co-purification of decorin, a novel SP-D-binding protein, from amniotic fluid...
  60. Gogiel T, Galewska Z, Romanowicz L, Jaworski S, Bankowski E. Pre-eclampsia-associated alterations in decorin, biglycan and versican of the umbilical cord vein wall. Eur J Obstet Gynecol Reprod Biol. 2007;134:51-6 pubmed
    ..b>Decorin, biglycan and versican are the main proteoglycans of the umbilical cord vein wall...
  61. Von Marschall Z, Fisher L. Decorin is processed by three isoforms of bone morphogenetic protein-1 (BMP1). Biochem Biophys Res Commun. 2010;391:1374-8 pubmed publisher
    The secreted small proteoglycan, decorin, modulates collagen fibril formation as well as the bioactivity of various members of the transforming growth factor-beta (TGFbeta) superfamily...
  62. Adam M, Schwarzer J, Kohn F, Strauss L, Poutanen M, Mayerhofer A. Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role of decorin in male infertility by interfering with growth factor signaling. Hum Reprod. 2011;26:2613-25 pubmed publisher
    ..cells in the walls of seminiferous tubules produce low levels of the extracellular matrix (ECM) protein decorin (DCN), which has the ability to interfere with growth factor (GF) signaling...
  63. Schmidt G, Hausser H, Kresse H. Interaction of the small proteoglycan decorin with fibronectin. Involvement of the sequence NKISK of the core protein. Biochem J. 1991;280 ( Pt 2):411-4 pubmed
    b>Decorin, an interstitial small proteoglycan, was shown to interact with fibronectin via its core protein...