DEC1

Summary

Gene Symbol: DEC1
Description: deleted in esophageal cancer 1
Alias: CTS9, deleted in esophageal cancer 1, candidate tumor suppressor CTS9
Species: human
Products:     DEC1

Top Publications

  1. Zheng Y, Jia Y, Wang Y, Wang M, Li B, Shi X, et al. The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in gastric cancer. OMICS. 2009;13:301-6 pubmed publisher
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1), as a bHLH transcriptional factor, plays important roles in cell differentiation, proliferation, and apoptosis...
  2. Qian Y, Jung Y, Chen X. DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem. 2011;286:12033-41 pubmed publisher
    ..Here, we showed that ?Np63 is regulated by the transcription factor DEC1, a p53 family target...
  3. Zheng Y, Shi X, Wang M, Jia Y, Li B, Zhang Y, et al. The increased expression of DEC1 gene is related to HIF-1? protein in gastric cancer cell lines. Mol Biol Rep. 2012;39:4229-36 pubmed publisher
    Overexpression of differentiated embryo chondrocyte 1 (DEC1) has been reported to contribute to the cellular differentiation, proliferation, and apoptosis of various cancers...
  4. Wu Y, Sato F, Yamada T, Bhawal U, Kawamoto T, Fujimoto K, et al. The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer. Int J Oncol. 2012;41:1337-46 pubmed publisher
    b>DEC1 (BHLHE40/Stra13/Sharp2) is a basic helix-loop-helix (bHLH) transcription factor that is involved in the regulation of apoptosis and cell proliferation and the response to hypoxia...
  5. Qian Y, Jung Y, Chen X. Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. Proc Natl Acad Sci U S A. 2012;109:11300-5 pubmed publisher
    ..Previously, we showed that DEC1, a basic helix-loop-helix transcription factor and a target of p53, is capable of inducing cell cycle arrest and ..
  6. Cao S, Zheng J, Liu X, Liu Y, Ruan X, Ma J, et al. FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG. J Exp Clin Cancer Res. 2019;38:37 pubmed publisher
    ..Western blot were used to explore the expression of FXR1, TAL1 and DEC1 in glioma tissues and cells...
  7. Sato F, Otsuka T, Kohsaka A, Le H, Bhawal U, Muragaki Y. Smad3 Suppresses Epithelial Cell Migration and Proliferation Via the Clock Gene Dec1, Which Negatively Regulates the Expression of Clock Genes Dec2 and Per1. Am J Pathol. 2019;: pubmed publisher
    ..Here, we investigated the regulatory mechanisms between Smad3 and the clock genes Dec1, Dec2, and Per1...
  8. Hsieh Li S, Liu S, Chang Y, Ho C, Huang S. Metformin causes cancer cell death through downregulation of p53-dependent differentiated embryo chondrocyte 1. J Biomed Sci. 2018;25:81 pubmed publisher
    ..had induced apoptosis through downregulation of p53 protein and a target gene, differentiated embryo chondrocyte 1 (DEC1)...
  9. Hu S, Shang W, Yue H, Chen R, Dong Z, Hu J, et al. Differentiated embryonic chondrocytes 1 expression of periodontal ligament tissue and gingival tissue in the patients with chronic periodontitis. Arch Oral Biol. 2015;60:517-25 pubmed publisher
    To evaluate the DEC1 expression of periodontal ligament tissue and gingival tissue in the patients with chronic periodontitis. 20 non-smoking patients with chronic periodontitis and 20 healthy individuals were enrolled...

More Information

Publications75

  1. Liu Y, Liu B, Zhang G, Zou J, Zou M, Cheng Z. Calpain inhibition attenuates bleomycin-induced pulmonary fibrosis via switching the development of epithelial-mesenchymal transition. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:695-704 pubmed publisher
    ..Furthermore, we found differentiated embryonic chondrocyte-expressed gene 1 (DEC1), an important transcription factor, was upregulated in both patients with idiopathic pulmonary fibrosis and in ..
  2. Gallo C, Fragliasso V, Donati B, Torricelli F, Tameni A, Piana S, et al. The bHLH transcription factor DEC1 promotes thyroid cancer aggressiveness by the interplay with NOTCH1. Cell Death Dis. 2018;9:871 pubmed publisher
    ..Recently, we found the basic helix-loop-helix transcription factors DEC1 and DEC2 significantly up-regulated in a model of highly aggressive thyroid cancer, raising the hypothesis that ..
  3. Chen R, Wang Y, Ning R, Hu J, Liu W, Xiong J, et al. Decreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1α/Stra13 pathway. Xenobiotica. 2015;45:782-93 pubmed publisher
    ..and the capacity of hydrolytic activity of liver and intestine decreased, whereas the Akt/mTOR/HIF-1α/ Stra13 (DEC1) signaling was activated in T2D mice...
  4. Wu Y, Sato H, Suzuki T, Yoshizawa T, Morohashi S, Seino H, et al. Involvement of c-Myc in the proliferation of MCF-7 human breast cancer cells induced by bHLH transcription factor DEC2. Int J Mol Med. 2015;35:815-20 pubmed publisher
    Differentiated embryonic chondrocyte expressed gene 1 (DEC1; BHLHE40/Stra13/Sharp2) and differentiated embryonic chondrocyte expressed gene 2 (DEC2; BHLHE41/Sharp1) are basic helix-loop-helix (bHLH) transcriptional factors that are ..
  5. Xu J, Huang Z, Lin L, Fu M, Song Y, Shen Y, et al. miRNA-130b is required for the ERK/FOXM1 pathway activation-mediated protective effects of isosorbide dinitrate against mesenchymal stem cell senescence induced by high glucose. Int J Mol Med. 2015;35:59-71 pubmed publisher
    ..as by the mRNA levels of DNA methyltransferase 1 (DNMT1) and differentiated embryo chondrocyte expressed gene 1 (DEC1), which are senescence-related biomarkers...
  6. Kato Y, Kawamoto T, Fujimoto K, Noshiro M. DEC1/STRA13/SHARP2 and DEC2/SHARP1 coordinate physiological processes, including circadian rhythms in response to environmental stimuli. Curr Top Dev Biol. 2014;110:339-72 pubmed publisher
    Daily physiological and behavioral rhythms are regulated by endogenous circadian molecular clocks. Clock proteins DEC1 (BHLHe40) and DEC2 (BHLHe41) belong to the basic helix-loop-helix protein superfamily, which contains other clock ..
  7. Jinhua H, Zhao M, Wei S, Haitao Y, Yuwen W, Lili W, et al. Down regulation of differentiated embryo-chondrocyte expressed gene 1 is related to the decrease of osteogenic capacity. Curr Drug Targets. 2014;15:432-41 pubmed
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is associated with chondrogenesis, neurogenesis, immune response, biological rhythm, lipogenesis, cell differentiation and carcinogenesis...
  8. Haridoss S, Yovchev M, Schweizer H, Megherhi S, Beecher M, Locker J, et al. Activin A is a prominent autocrine regulator of hepatocyte growth arrest. Hepatol Commun. 2017;1:852-870 pubmed publisher
    ..kinase inhibitor 2B [p15INK4b/CDKN2B], differentiated embryo-chondrocyte expressed gene 1 [DEC1]) and reduced proliferation and induction of senescence...
  9. Ming X, Bao C, Hong T, Yang Y, Chen X, Jung Y, et al. Clusterin, a Novel DEC1 Target, Modulates DNA Damage-Mediated Cell Death. Mol Cancer Res. 2018;16:1641-1651 pubmed publisher
    Differentiated embryonic chondrocyte expressed gene 1 (DEC1, also known as Sharp2/Stra13/BHLHE40) is a basic helix-loop-helix transcription factor that plays an important role in circadian rhythms, cell proliferation, apoptosis, cellular ..
  10. Wu T, Tao Y, Tsang F, Abe K, Xu L, Jiang Q, et al. The effect of L-carnosine on the circadian resetting of clock genes in the heart of rats. Mol Biol Rep. 2015;42:87-94 pubmed publisher
    ..Car-feeding obviously enhanced the resetting rates of clock genes (Bmal1, Dec1, Cry1) in the heart of normal rats after the experimental jet lag...
  11. Zheng Q, Wang C, Wang L, Zhang D, Liu N, Ming X, et al. Interaction with SP1, but not binding to the E-box motifs, is responsible for BHLHE40/DEC1-induced transcriptional suppression of CLDN1 and cell invasion in MCF-7 cells. Mol Carcinog. 2018;57:1116-1129 pubmed publisher
    ..These results suggest that BHLHE40 facilitates cell invasion and may be used as a novel target for breast cancer prevention and treatment. ..
  12. Baier P, Brzózka M, Shahmoradi A, Reinecke L, Kroos C, Wichert S, et al. Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders. PLoS ONE. 2014;9:e110310 pubmed publisher
    ..The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are modulators of the circadian system and SHARP1/DEC2/BHLHE40 has been shown to regulate homeostatic sleep ..
  13. Nakashima A, Kawamoto T, Noshiro M, Ueno T, Doi S, Honda K, et al. Dec1 and CLOCK Regulate Na+/K+-ATPase β1 Subunit Expression and Blood Pressure. Hypertension. 2018;72:746-754 pubmed publisher
    ..receptor nuclear translocator-like protein-1) heterodimer enhances promoter activity of clock genes, and DEC1 (BHLHE40/STRA13/SHARP-2) represses CLOCK/BMAL1-enhanced promoter activity through competition for binding to the ..
  14. Camponeschi A, Todi L, Cristofoletti C, Lazzeri C, Carbonari M, Mitrevski M, et al. DEC1/STRA13 is a key negative regulator of activation-induced proliferation of human B cells highly expressed in anergic cells. Immunol Lett. 2018;198:7-11 pubmed publisher
    The transcription factor DEC1/STRA13 (also known as BHLHE40 and SHARP2) is involved in a number of processes including inhibition of cell proliferation and delay of cell cycle, and is a negative regulator of B cell activation and ..
  15. Mogi A, Yomoda R, Kimura S, Tsushima C, Takouda J, Sawauchi M, et al. Entrainment of the Circadian Clock in Neural Stem Cells by Epidermal Growth Factor is Closely Associated with ERK1/2-mediated Induction of Multiple Clock-related Genes. Neuroscience. 2018;379:45-66 pubmed publisher
    ..validation demonstrated that EGF treatment transiently induced multiple clock-related genes including Per1, Per2, Dec1, e4bp4, and Noct, whereas FK treatment induced a limited number of genes (Per1 and Dec1), suggesting that the mode ..
  16. Hu J, Mao Z, He S, Zhan Y, Ning R, Liu W, et al. Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3?/?-catenin integrated signaling pathway. Biochem Pharmacol. 2017;136:109-121 pubmed publisher
    ..We have also shown that dexamethasone (a glucocorticoid) suppressed and icariin induced DEC1, a structurally distinct helix-loop-helix protein...
  17. Xiong J, Yang H, Luo W, Shan E, Liu J, Zhang F, et al. The anti-metastatic effect of 8-MOP on hepatocellular carcinoma is potentiated by the down-regulation of bHLH transcription factor DEC1. Pharmacol Res. 2016;105:121-33 pubmed publisher
    ..Differentiated embryonic chondrocyte-expressed gene 1, DEC1 (BHLHE40/Stra13/Sharp2), is a basic helix-loop-helix (bHLH) transcription factor that regulates cell growth, ..
  18. Chen L, Zhou J, Xu H, Xu G, Xue J. Identification and developmental expression of Dec2 in zebrafish. Fish Physiol Biochem. 2010;36:667-675 pubmed publisher
    ..The embryonic expression patterns of zebrafish Dec2 and its homolog Dec1 partially overlap, but are distinct from each other...
  19. Zhou J, Yu W, Hardin P. CLOCKWORK ORANGE Enhances PERIOD Mediated Rhythms in Transcriptional Repression by Antagonizing E-box Binding by CLOCK-CYCLE. PLoS Genet. 2016;12:e1006430 pubmed publisher
    ..Given that CWO orthologs DEC1 and DEC2 also target E-boxes bound by CLOCK-BMAL1, a similar mechanism may operate in the mammalian clock.
  20. Olkkonen J, Kouri V, Hynninen J, Konttinen Y, Mandelin J. Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis. PLoS ONE. 2015;10:e0145279 pubmed publisher
    ..Our objective was to investigate the expression of direct clock suppressors DEC1 and DEC2 (BHLHE 40 and 41 proteins) in response to TNFα and investigate their role during inflammation...
  21. LaGory E, Wu C, Taniguchi C, Ding C, Chi J, von Eyben R, et al. Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. Cell Rep. 2015;12:116-127 pubmed publisher
    ..demonstrate that PGC-1α, a central regulator of energy metabolism, is suppressed in VHL-deficient ccRCC by a HIF/Dec1-dependent mechanism...
  22. Bi H, Li S, Qu X, Wang M, Bai X, Xu Z, et al. DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase. Cell Death Dis. 2015;6:e1891 pubmed publisher
    ..The transcription factor DEC1 (also known as STRA13 and SHARP2) plays an important role in cell proliferation and apoptosis...
  23. Giannoni E, Taddei M, Morandi A, Comito G, Calvani M, Bianchini F, et al. Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread. Oncotarget. 2015;6:24061-74 pubmed
    ..inducible factor-1α (HIF-1α) and the transcriptional repressor Differentially Expressed in Chondrocytes-1 (DEC1)...
  24. Wu T, Yao C, Tsang F, Huang L, Zhang W, Jiang J, et al. Facilitated physiological adaptation to prolonged circadian disruption through dietary supplementation with essence of chicken. Chronobiol Int. 2015;32:1458-68 pubmed publisher
    ..A recent study revealed that it facilitated the re-entrainment of clock genes (Bmal1, Cry1, Dec1, Per1 and Per2) in the pineal gland and liver in a rat model of circadian disruption...
  25. You J, Su T, Xia K, Liu Q. [Expression of differentiated embryo-chondrocyte expressed gene l in oral squamous cell carcinoma and its clinical significance]. Shanghai Kou Qiang Yi Xue. 2016;25:217-20 pubmed
    To investigate the expression of differentiated embryo-chondrocyte expressed gene l?DEC1?in oral squamous cell carcinoma?OSCC?and its clinical significance...
  26. Zhao Q, Zheng G, Yang K, Ao Y, Su X, Li Y, et al. The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells. Oncotarget. 2016;7:70290-70302 pubmed publisher
    ..Quantitative real-time PCR result indicated that in vitro and in vivo cancer cells after PER1 knockdown, PER2, DEC1, DEC2, CRY1, CRY2 and NPAS2 were significantly down-regulated at the mRNA level, while PER3, TIM, RORα and REV-..
  27. Sato M, Wakamura T, Morita T, Okamoto A, Akashi M, Matsui T, et al. Effects of bright light exposure during daytime on peripheral clock gene expression in humans. Int J Biometeorol. 2017;61:1133-1138 pubmed publisher
    ..The mRNA expression of Per1-3, Cry1-2, Rev-erb-α (Nr1d1), Rev-erb-β (Nr1d2), and Dec1 was analyzed using branched DNA probes...
  28. Sato F, Muragaki Y, Zhang Y. DEC1 negatively regulates AMPK activity via LKB1. Biochem Biophys Res Commun. 2015;467:711-6 pubmed publisher
    Basic helix-loop-helix (bHLH) transcription factor DEC1 (bHLHE40/Stra13/Sharp2) is one of the clock genes that show a circadian rhythm in various tissues...
  29. Sato F, Kohsaka A, Bhawal U, Muragaki Y. Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism. Int J Mol Sci. 2018;19: pubmed publisher
    ..Among the clock genes, Dec1 (Bhlhe40/Stra13/Sharp2), Dec2 (Bhlhe41/Sharp1), and Bmal1 (..
  30. Fujita Y, Makishima M, Bhawal U. Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. Biochem Biophys Res Commun. 2016;469:477-82 pubmed publisher
    Human differentiated embryo chondrocyte expressed gene 1 (DEC1) is frequently used as a marker of senescence in vivo...
  31. Long Y, Tsai W, Chang J, Estecio M, Wangpaichitr M, Savaraj N, et al. Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. Oncotarget. 2016;7:82658-82670 pubmed publisher
    ..We further demonstrated that the clock protein DEC1 is the master regulator of HIF-1α and c-Myc that regulate ASS1...
  32. Liu Q, Wu Y, Yoshizawa T, Yan X, Morohashi S, Seino H, et al. Basic helix-loop-helix transcription factor DEC2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells. Int J Mol Med. 2016;38:1727-1733 pubmed publisher
    ..However, little is known regarding the expression of DEC1 and DEC2 in prostate cancer cells...
  33. Murakami K, Wu Y, Imaizumi T, Aoki Y, Liu Q, Yan X, et al. DEC1 promotes hypoxia-induced epithelial-mesenchymal transition (EMT) in human hepatocellular carcinoma cells. Biomed Res. 2017;38:221-227 pubmed publisher
    ..However, it remains unclear whether DEC1 participates in hypoxia-mediated EMT processes...
  34. Kunimoto Y, Nakano S, Kataoka H, Shimada Y, Oshimura M, Kitano H. Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines. ORL J Otorhinolaryngol Relat Spec. 2011;73:17-23 pubmed publisher
    Previous studies have shown that the expression of Deleted in Esophageal Cancer 1 (DEC1) is significantly reduced in esophageal squamous cell carcinoma...
  35. Marczak M, Yan B. Circadian rhythmicity: A functional connection between differentiated embryonic chondrocyte-1 (DEC1) and small heterodimer partner (SHP). Arch Biochem Biophys. 2017;631:11-18 pubmed publisher
    ..maintains metabolic homeostasis and expresses many circadian genes, such as differentiated embryo chondrocyte-1 (DEC1) and small heterodimer partner (SHP)...
  36. Jia Y, Hu R, Li P, Zheng Y, Wang Y, Ma X. DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression. Gastric Cancer. 2018;21:632-642 pubmed publisher
    Human differentiated embryonic chondrocyte-expressed gene 1 (DEC1), which has been reported to be overexpressed in several types of cancer, is associated with tumorigenesis through participation in several biological processes...
  37. Delestré L, Cui H, Esposito M, Quiveron C, Mylonas E, Penard Lacronique V, et al. Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells. Haematologica. 2017;102:1850-1860 pubmed publisher
    ..response is lost during the progression of the disease and erythroid blasts do not display a higher expression of Dec1 and CDKN1A, two of the induced senescence markers in young animals...
  38. Leung A, Wong V, Yang L, Chan P, Daigo Y, Nakamura Y, et al. Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. Int J Cancer. 2008;122:587-94 pubmed
    Previous studies showed that expression of the novel candidate tumor suppressor gene, DEC1 (Deleted in Esophageal Cancer 1), is reduced in esophageal carcinoma and suppresses cancer cell growth in vitro and tumor growth in vivo in nude ..
  39. Kim J, D Annibale S, Magliozzi R, Low T, Jansen P, Shaltiël I, et al. USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response. Mol Cell Biol. 2014;34:4177-85 pubmed publisher
    ..Here we show that the degradation of the basic helix-loop-helix (bHLH) transcription factor DEC1, a critical regulator of cell fate and circadian rhythms, controls the DNA damage response...
  40. Chu Y, Liu S, Yang Y, Huang S, Wang W. The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes. J Biomed Sci. 2017;24:55 pubmed publisher
    ..It also induced the expression of p21 and DEC1 (differentiated embryo-chondrocyte expressed gene 1), and promoted G1 arrest of cell cycle in proliferative ..
  41. Zhao M, Xiaofei L, Gang C, Wei L, Jing X, Gang H, et al. DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem Pharmacol. 2012;84:701-711 pubmed publisher
    ..After human hepatocytes were treated with IL-6, differentially expressed in chondrocytes 1 (DEC1) expression rapidly increased, and subsequently, the CYP3A4 expression decreased continuously...
  42. Liu H, Irwanto A, Fu X, Yu G, Yu Y, Sun Y, et al. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. Nat Genet. 2015;47:267-71 pubmed publisher
    ..Further analysis suggests that molecular sensing of infection might have a similar pathogenic role across these diseases, whereas immune responses have discordant roles in infectious and inflammatory diseases. ..
  43. Zhu Z, Wang Y, Ge D, Lu M, Liu W, Xiong J, et al. Downregulation of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing PI3K/Akt/GSK3β pathway. CNS Neurosci Ther. 2017;23:736-747 pubmed publisher
    Differentiated embryonic chondrocyte gene 1 (DEC1) is involved in the neuronal differentiation and development...
  44. You J, Lin L, Liu Q, Zhu T, Xia K, Su T. The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma. Eur J Med Res. 2014;19:21 pubmed publisher
    This study aims to explore the correlation between expression of differentiated embryo-chondrocyte expressed gene l (DEC1) and oral squamous cell carcinoma (OSCC), which could provide the reference for treatment and prognosis assessment ..
  45. Ma W, Shi X, Lu S, Wu L, Wang Y. Hypoxia-induced overexpression of DEC1 is regulated by HIF-1? in hepatocellular carcinoma. Oncol Rep. 2013;30:2957-62 pubmed publisher
    Hypoxia-inducible factor-1? (HIF-1?) and differentiated embryo-chondrocyte expressed gene 1 (DEC1) are two key factors that protect hepatocellular carcinoma (HCC) cells from a hypoxic microenvironment...
  46. Hiramoto K, Yamate Y, Yokoyama S. Ultraviolet A Eye Irradiation Ameliorates Atopic Dermatitis via p53 and Clock Gene Proteins in NC/Nga Mice. Photochem Photobiol. 2017;: pubmed publisher
    ..the levels of thymic stromal lymphopoetin (TSLP), period 2 (PER2), and differentiated embryo chondrocytes 1 (DEC1) protein were decreased in mice treated with UVA irradiation...
  47. Bhawal U, Ito Y, Tanimoto K, Sato F, Fujimoto K, Kawamoto T, et al. IL-1?-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway. J Cell Biochem. 2012;113:3246-53 pubmed publisher
    ..However, pathways involved in this progression are not well understood. The involvement of DEC1 in cancer prompted us to examine whether pro-inflammatory cytokine interleukin-1? (IL-1?) induces the expression of ..
  48. Seino H, Wu Y, Morohashi S, Kawamoto T, Fujimoto K, Kato Y, et al. Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells. Biomed Res. 2015;36:89-96 pubmed publisher
    b>DEC1 [basic helix-loop-helix (BHLH) E40/Stra13/Sharp2] and DEC2 (BHLHE41/Sharp1) are BHLH transcription factors that are associated with the regulation of apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in ..
  49. Li X, Lin W, Wang J, Zhang W, Yin A, Huang Y, et al. Dec1 expression predicts prognosis and the response to temozolomide chemotherapy in patients with glioma. Mol Med Rep. 2016;14:5626-5636 pubmed publisher
    Differentiated embryo chondrocyte expressed gene 1 (Dec1), a crucial cell differentiation mediator and apoptosis inhibitor, is abundantly expressed in various types of human cancer and is associated with malignant tumor progression...
  50. Hong Y, Xing X, Li S, Bi H, Yang C, Zhao F, et al. SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability. PLoS ONE. 2011;6:e23046 pubmed publisher
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1, also known as sharp2, stra13, or BHLHB2) is a mammalian basic helix-loop-helix protein that is involved in many aspects of gene regulation through acting as a transcription factor...
  51. Qian Y, Zhang J, Jung Y, Chen X. DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ?Np73 expression. PLoS ONE. 2014;9:e84015 pubmed publisher
    ..Here, we reported that transcriptional factor DEC1, a target of the p53 family, exerts a distinct control of TAp73 and ?Np73 expression...
  52. Ning R, Zhan Y, He S, Hu J, Zhu Z, Hu G, et al. Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXR? and Suppresses the Expression of PXR, CAR and Their Target Genes. Front Pharmacol. 2017;8:866 pubmed publisher
    ..b>DEC1 (differentiated embryonic chondrocyte-expressed gene 1) is a ligand-independent transcription factor and reportedly ..
  53. Wu C, Kraft P, Stolzenberg Solomon R, Steplowski E, Brotzman M, Xu M, et al. Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut. 2014;63:152-60 pubmed publisher
    ..Germline genetic variation in the SBF2 locus was associated with overall survival in patients with pancreatic adenocarcinoma of European and Asian ancestry. This association should be investigated in additional large patient cohorts. ..
  54. Liu Y, Wang L, Lin X, Wang J, Yu J, Miao Y, et al. The transcription factor DEC1 (BHLHE40/STRA13/SHARP-2) is negatively associated with TNM stage in non-small-cell lung cancer and inhibits the proliferation through cyclin D1 in A549 and BE1 cells. Tumour Biol. 2013;34:1641-50 pubmed publisher
    ..the expression pattern and clinicopathological significance of differentiated embryo-chondrocyte-expressed gene 1 (DEC1) in patients with non-small-cell lung cancer (NSCLC)...
  55. Xu Q, Ma P, Hu C, Chen L, Xue L, Wang Z, et al. Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma. PLoS ONE. 2012;7:e41862 pubmed publisher
    ..Human differentiated embryo chondrocyte expressed gene 1 (Dec1) is an important transcription factor that related to senescence...
  56. Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32. Genes Chromosomes Cancer. 2000;27:169-76 pubmed
    ..Here we report the isolation of a novel gene, DEC1 (deleted in esophageal cancer 1), from the target region...
  57. Huang Y, Niu J, Wei S, Yin M, Liu Z, Wang L, et al. A novel functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck. Carcinogenesis. 2010;31:2082-90 pubmed publisher
    Human DEC1 (deleted in esophageal cancer 1) gene is located on chromosome 9q, a region frequently deleted in various types of human cancers, including squamous cell carcinoma of the head and neck (SCCHN)...
  58. Shang W, Liu J, Chen R, Ning R, Xiong J, Liu W, et al. Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells. Xenobiotica. 2016;46:393-405 pubmed publisher
    ..the target genes such as CYP3A4, whereas increased the differentiated embryonic chondrocyte-expressed gene 1 (DEC1) expression. 3. FLX repressed the PXR at transcriptional level. 4...
  59. Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, et al. Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q. Cancer Res. 1996;56:1629-34 pubmed
  60. Wu T, Fu Z. Time-dependent glucocorticoid administration differently affects peripheral circadian rhythm in rats. Acta Biochim Biophys Sin (Shanghai). 2017;49:1122-1128 pubmed publisher
    ..Real-time RT-PCR analysis indicated that the transcript levels of Per1 and Dec1 were rapidly up-regulated within 0...
  61. Wang X, Wang Q, Lin H, Chang N. Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma. Food Funct. 2017;8:3319-3326 pubmed publisher
    ..The expression of DEC1, HIF-1?, STAT3 and VEGF in tumor tissues was examined by immunostaining and analyzed using an Image J analysis ..
  62. Yang L, Leung A, Ko J, Lo P, Tang J, Srivastava G, et al. Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma. Oncogene. 2005;24:697-705 pubmed
    ..Absent to low expression of a 9q32 candidate tumor suppressor gene (TSG), DEC1 (deleted in esophageal cancer 1), is detected in four Asian ESCC cell lines...
  63. Xie X, Guo A, Wu T, Hu Q, Huang L, Yao C, et al. Preventive effect of L-carnitine on the disorder of lipid metabolism and circadian clock of mice subjected to chronic jet-lag. Physiol Res. 2017;66:801-810 pubmed
    ..metabolism (Srebp1, Acaca, Fasn, and Scd1), metabolic regulator (mTOR) and circadian rhythm (Bmal1, Per1, Cry1 and Dec1) in the liver of mice subjected to the chronic jet-lag...
  64. Zhu Y, Xu L, Zhang J, Hu X, Liu Y, Yin H, et al. Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells. Cancer Sci. 2013;104:1052-61 pubmed publisher
    ..that sunitinib-treated RCC cells exhibit senescence characteristics including increased SA-?-gal activity, DcR2 and Dec1 expression, and senescence-associated secretary phenotype (SASP) such as proinflammatory cytokines interleukin (IL)-..
  65. Li Y, Shen Q, Kim H, Bissonnette R, Lamph W, Yan B, et al. The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor. Breast Cancer Res Treat. 2011;128:667-77 pubmed publisher
    ..By elucidating the mechanism by which rexinoids inhibit cell proliferation, it will be possible to develop more effective and less toxic drugs to prevent ER-negative breast cancers. ..
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    ..We also examined Smad3, Bmal1 and Dec1 expression in human tissue from old myocardial infarctions...