DDX39B

Summary

Gene Symbol: DDX39B
Description: DExD-box helicase 39B
Alias: BAT1, D6S81E, UAP56, spliceosome RNA helicase DDX39B, 56 kDa U2AF65-associated protein, ATP-dependent RNA helicase p47, DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B, DEAD-box helicase 39B, HLA-B-associated transcript 1 protein, nuclear RNA helicase (DEAD family), spliceosome RNA helicase BAT1
Species: human
Products:     DDX39B

Top Publications

  1. Cherry C, Rosenow A, Affandi J, McArthur J, Wesselingh S, Price P. Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN risk. AIDS Res Hum Retroviruses. 2008;24:117-23 pubmed publisher
    ..b>BAT1 (intron 10)*2 was more common in NRTI-SN than resistant patients, but neither group differed from controls...
  2. Li Y, Wang X, Zhang X, Goodrich D. Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. Mol Cell Biol. 2005;25:4023-33 pubmed
    ..that human hHpr1/p84/Thoc1 associates with elongating RNA polymerase II and the RNA splicing and export factor UAP56 in intact cells...
  3. Shen J, Zhang L, Zhao R. Biochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factor. J Biol Chem. 2007;282:22544-50 pubmed
    DEXD/H-box protein UAP56 is an essential pre-mRNA splicing factor required for the first ATP-dependent spliceosome assembly step. UAP56 is also essential for the export of the majority of mRNAs from the nucleus to the cytoplasm...
  4. Fleckner J, Zhang M, Valcarcel J, Green M. U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev. 1997;11:1864-72 pubmed
    ..region of U2AF65 required for function, and use this information to clone a human 56-kD U2AF65 associated protein (UAP56)...
  5. Oliveira L, Porta G, Marin M, Bittencourt P, Kalil J, Goldberg A. Autoimmune hepatitis, HLA and extended haplotypes. Autoimmun Rev. 2011;10:189-93 pubmed publisher
    ..AIH-1 children and up to 326 healthy subjects for TNFA G-308A, TNFA G-238A, LTA A+252G, LTA A+80C, NFKBIL1 T-63A, BAT1 C-348T, BAT1 G-22C, MICA, and HLA-B polymorphisms...
  6. Zhao R, Shen J, Green M, MacMorris M, Blumenthal T. Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export. Structure. 2004;12:1373-81 pubmed
    b>UAP56 is an essential eukaryotic pre-mRNA splicing factor and mRNA export factor. The mechanisms of its functions are not well understood...
  7. Pryor A, Tung L, Yang Z, Kapadia F, Chang T, Johnson L. Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56. Nucleic Acids Res. 2004;32:1857-65 pubmed
    URH49 is a mammalian protein that is 90% identical to the DExH/D box protein UAP56, an RNA helicase that is important for splicing and nuclear export of mRNA...
  8. Spies T, Bresnahan M, Strominger J. Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. Proc Natl Acad Sci U S A. 1989;86:8955-8 pubmed
    ..Moreover, a cluster of genes, BAT1-BAT5 (HLA-B-associated transcripts) has been localized in the vicinity of the genes for TNF alpha and TNF beta...
  9. Cheng H, Dufu K, Lee C, Hsu J, Dias A, Reed R. Human mRNA export machinery recruited to the 5' end of mRNA. Cell. 2006;127:1389-400 pubmed
    ..As a consequence, the mRNA would be exported in a 5' to 3' direction through the nuclear pore, as observed in early electron micrographs of giant Balbiani ring mRNPs. ..

More Information

Publications86

  1. Shen H, Zheng X, Shen J, Zhang L, Zhao R, Green M. Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome. Genes Dev. 2008;22:1796-803 pubmed publisher
    The essential splicing factor human UAP56 (hUAP56) is a DExD/H-box protein known to promote prespliceosome assembly...
  2. Guo S, Hakimi M, Baillat D, Chen X, Farber M, Klein Szanto A, et al. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res. 2005;65:3011-6 pubmed
    ..These results not only identify hTREX84 as a prognosticator of breast cancer but also delineate human TREX complex as a target for therapeutic drugs against breast cancer. ..
  3. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez Navarro S, et al. TREX is a conserved complex coupling transcription with messenger RNA export. Nature. 2002;417:304-8 pubmed
    ..Yra1 and Sub2 are messenger RNA export factors that have conserved counterparts in metazoans, designated Aly and UAP56, respectively. These factors couple the machineries that function in splicing and export of mRNA...
  4. Luo M, Zhou Z, Magni K, Christoforides C, Rappsilber J, Mann M, et al. Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature. 2001;413:644-7 pubmed
    ..Here we show that the conserved DEAD-box helicase UAP56, which functions during spliceosome assembly, interacts directly and highly specifically with Aly...
  5. Allcock R, Williams J, Price P. The central MHC gene, BAT1, may encode a protein that down-regulates cytokine production. Genes Cells. 2001;6:487-94 pubmed
    b>BAT1 belongs to the DEAD-box family of RNA-binding proteins and is encoded in the central MHC...
  6. Kapadia F, Pryor A, Chang T, Johnson L. Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49. Gene. 2006;384:37-44 pubmed
    b>UAP56 is a eukaryotic RNA helicase that is important for mRNA splicing and nuclear export...
  7. Boyne J, Colgan K, Whitehouse A. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. PLoS Pathog. 2008;4:e1000194 pubmed publisher
    ..Aly in turn interacts directly with the DEAD-box protein UAP56, which functions as a bridge to recruit the remaining hTREX proteins to the complex...
  8. Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, et al. The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression. Mol Biol Cell. 2010;21:2953-65 pubmed publisher
    ..a core component of the TREX complex in yeast, has diversified in humans to two closely related RNA helicases, UAP56 and URH49...
  9. Dufu K, Livingstone M, Seebacher J, Gygi S, Wilson S, Reed R. ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Genes Dev. 2010;24:2043-53 pubmed publisher
    The conserved TREX mRNA export complex is known to contain UAP56, Aly, Tex1, and the THO complex...
  10. Allcock R, Price P, Gaudieri S, Leelayuwat C, Witt C, Dawkins R. Characterisation of the human central MHC gene, BAT1: genomic structure and expression. Exp Clin Immunogenet. 1999;16:98-106 pubmed
    The BAT1 gene (D6S81E) encodes a member of the DEAD-box family of RNA-binding proteins, and lies in the central MHC. This region contains genes which affect susceptibility to immunopathological diseases...
  11. Quiñones Lombraña A, Lopez Soto A, Ballina Garcia F, Alperi López M, Queiro Silva R, Lopez Vazquez A, et al. BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility. J Rheumatol. 2008;35:741-4 pubmed
    To analyze whether the polymorphisms -22 (G/C) and -348 (C/T) of the BAT1 gene are associated with susceptibility to rheumatoid arthritis (RA)...
  12. Koch W, Hoppmann P, Michou E, Jung V, Pfeufer A, Mueller J, et al. Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans. Hum Mol Genet. 2007;16:1821-7 pubmed
    Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13...
  13. Lischka P, Toth Z, Thomas M, Mueller R, Stamminger T. The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA. Mol Cell Biol. 2006;26:1631-43 pubmed
    ..the cellular mRNA export machinery by direct protein interaction with the highly related DEXD/H-box RNA helicases UAP56 and URH49...
  14. Kota K, Wagner S, Huerta E, Underwood J, Nickerson J. Binding of ATP to UAP56 is necessary for mRNA export. J Cell Sci. 2008;121:1526-37 pubmed publisher
    The major-histocompatibility-complex protein UAP56 (BAT1) is a DEAD-box helicase that is deposited on mRNA during splicing...
  15. Gnjec A, D Costa K, Laws S, Hedley R, Balakrishnan K, Taddei K, et al. Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. J Neuroinflammation. 2008;5:36 pubmed publisher
    ..The gene coding for HLA-B associated transcript 1 (BAT1) lies adjacent to TNFA in the central major histocompatibility complex (MHC)...
  16. Price P, Wong A, Williamson D, Voon D, Baltic S, Allcock R, et al. Polymorphisms at positions -22 and -348 in the promoter of the BAT1 gene affect transcription and the binding of nuclear factors. Hum Mol Genet. 2004;13:967-74 pubmed
    BAT1 (D6S81E, UAP56) lies in the central MHC between TNF and HLA-B, a region containing genes that affect susceptibility to immunopathologic disorders...
  17. Hautbergue G, Hung M, Walsh M, Snijders A, Chang C, Jones R, et al. UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA. Curr Biol. 2009;19:1918-24 pubmed publisher
    ..The canonical adaptor REF/ALY/Yra1 is recruited to mRNA via UAP56 and subsequently delivers the mRNA to NXF1 [1]...
  18. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev. 2005;19:1512-7 pubmed
  19. Leaw C, Ren E, Choong M. Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. Cell Mol Life Sci. 2004;61:2264-73 pubmed
    ..Using a yeast two-hybrid screen, two DEAD-box RNA helicases, BAT1 and DDX39, were identified as proteins that interact with Hcc-1...
  20. Dias A, Dufu K, Lei H, Reed R. A role for TREX components in the release of spliced mRNA from nuclear speckle domains. Nat Commun. 2010;1:97 pubmed publisher
    ..When the TREX components UAP56 or Aly are knocked down, spliced mRNA, as well as total polyA+ RNA, accumulates in nuclear speckle domains...
  21. Watanabe J, Uehara K, Mogi Y. Both BAT1 and ARO8 are responsible for unpleasant odor generation in halo-tolerant yeast Zygosaccharomyces rouxii. Appl Microbiol Biotechnol. 2015;99:7685-97 pubmed publisher
    ..A mutant lacking the BCAA transaminase gene, BAT1, resulted in valine and isoleucine auxotrophy, while a mutant lacking both BAT1 and the α-aminoadipate ..
  22. Ehrnsberger H, Pfaff C, Hachani I, Flores Tornero M, Sørensen B, Längst G, et al. The UAP56-Interacting Export Factors UIEF1 and UIEF2 Function in mRNA Export. Plant Physiol. 2019;179:1525-1536 pubmed publisher
    ..The Arabidopsis (Arabidopsis thaliana) genome encodes two likely orthologs of UAP56-interacting factor, which acts as mRNA export factor in mammalian cells...
  23. Kronemann D, Hagemeier S, Cygnar D, Phillips S, Bresnahan W. Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV. J Virol. 2010;84:9649-54 pubmed publisher
    ..to HCMV replication have been proposed, including UL69's ability to interact with the mRNA export factors UAP56 and URH49 to facilitate the shuttling of viral mRNAs from the nuclei of infected cells...
  24. Antunes D, Chowdhury A, Aich A, Saladi S, Harpaz N, Stahl M, et al. Overexpression of branched-chain amino acid aminotransferases rescues the growth defects of cells lacking the Barth syndrome-related gene TAZ1. J Mol Med (Berl). 2019;97:269-279 pubmed publisher
    ..We identified the branched-chain amino acid transaminases (BCATs) Bat1 and Bat2 as such suppressors...
  25. Zhang C, Qi Y, Ma H, Li W, Dai L, Xiao D. Decreased production of higher alcohols by Saccharomyces cerevisiae for Chinese rice wine fermentation by deletion of Bat aminotransferases. J Ind Microbiol Biotechnol. 2015;42:617-25 pubmed publisher
    ..In this study, BAT1 and BAT2 single- and double-gene-deletion mutant strains were constructed from an industrial yeast strain RY1 to ..
  26. Wang K, Wang L, Wang J, Chen S, Shi M, Cheng H. Intronless mRNAs transit through nuclear speckles to gain export competence. J Cell Biol. 2018;217:3912-3929 pubmed publisher
    ..Upon NXF1 depletion, the TREX protein UAP56 loses speckle concentration but coaccumulates with intronless mRNAs and polyA RNAs in the nucleoplasm, and these ..
  27. Soosanabadi M, Bayat H, Kamali K, Saliminejad K, Banan M, Khorram Khorshid H. Association Study of IL-4 -590 C/T and DDX39B -22 G/C Polymorphisms with the Risk of Late-Onset Alzheimer's Disease in Iranian Population. Curr Aging Sci. 2015;8:276-81 pubmed
    ..DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B), appears to be involved in regulation of the inflammatory cytokines which are in correlation with AD pathology...
  28. Zhang F, Wang J, Xu J, Zhang Z, Koppetsch B, Schultz N, et al. UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery. Cell. 2012;151:871-884 pubmed publisher
    ..The nuclear DEAD box protein UAP56 has been previously implicated in mRNA splicing and export, whereas the DEAD box protein Vasa has an established ..
  29. Park S, Kim S, Hahn J. Metabolic engineering of Saccharomyces cerevisiae for the production of isobutanol and 3-methyl-1-butanol. Appl Microbiol Biotechnol. 2014;98:9139-47 pubmed publisher
    ..First, ALD6 encoding aldehyde dehydrogenase and BAT1 involved in valine synthesis were deleted to eliminate competing pathways...
  30. Tuteja N, Tarique M, Trivedi D, Sahoo R, Tuteja R. Stress-induced Oryza sativa BAT1 dual helicase exhibits unique bipolar translocation. Protoplasma. 2015;252:1563-74 pubmed publisher
    HLA-B associated transcript 1 (BAT1) protein, also named as spliceosome RNA helicase UAP56, is a member of the DExD/H-box family of helicases...
  31. Ali S, Chopra R, Aggarwal S, Srivastava A, Kalaiarasan P, Malhotra D, et al. Association of variants in BAT1-LTA-TNF-BTNL2 genes within 6p21.3 region show graded risk to leprosy in unrelated cohorts of Indian population. Hum Genet. 2012;131:703-16 pubmed publisher
    ..3 with a resolution of 1SNP/127 bp; and the SNPs in flanking BAT1, NFKBIL and BTNL2-DRA genes on the basis of their tag status or their presence in promoter/exonic regions with MAF ..
  32. Huang C, Liang D, Tatomer D, Wilusz J. A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Genes Dev. 2018;32:639-644 pubmed publisher
    ..The human homologs of Hel25E similarly regulate circRNA localization, as depletion of UAP56 (DDX39B) or URH49 (DDX39A) causes long and short circRNAs, respectively, to become enriched in the nucleus...
  33. Kawaguchi A. [Dynamics of the influenza virus genome regulated by cellular host factors]. Uirusu. 2017;67:59-68 pubmed publisher
    ..concert with the replication reaction, the nascent RNA chains are encapsidated with NP by cellular splicing factor UAP56. Further, after nuclear export of vRNP, we revealed that vRNP is transported to the plasma membrane using ..
  34. Serpeloni M, Jiménez Ruiz E, Vidal N, Kroeber C, Andenmatten N, Lemgruber L, et al. UAP56 is a conserved crucial component of a divergent mRNA export pathway in Toxoplasma gondii. Mol Microbiol. 2016;102:672-689 pubmed publisher
    ..With the exception of UAP56, a component of TREX (Transcription Export) complex, other components of mRNA export machinery are not well ..
  35. Krogerus K, Arvas M, De Chiara M, Magalhães F, Mattinen L, Oja M, et al. Ploidy influences the functional attributes of de novo lager yeast hybrids. Appl Microbiol Biotechnol. 2016;100:7203-22 pubmed publisher
    ..revealed that several genes related to the formation of flavor-active esters (ATF1, ATF2¸ EHT1, EEB1, and BAT1) were present in higher copy numbers in the higher ploidy hybrid strains...
  36. Kingsbury J, Sen N, Cardenas M. Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae. PLoS Genet. 2015;11:e1005714 pubmed publisher
    ..branched-chain aminotransferases (BCAT), which in yeast are represented by the mitochondrial and cytosolic enzymes Bat1 and Bat2, respectively...
  37. GALARZA MUNOZ G, Briggs F, Evsyukova I, Schott Lerner G, Kennedy E, Nyanhete T, et al. Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk. Cell. 2017;169:72-84.e13 pubmed publisher
    ..Here, we identified the RNA helicase DDX39B as a potent activator of this exon and consequently a repressor of sIL7R, and we found strong genetic association ..
  38. Majerciak V, Deng M, Zheng Z. Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57. Virology. 2010;407:206-12 pubmed publisher
    ..In this report, we examined how RNA export factors UAP56 and URH49, and RNA export cofactors RBM15 and OTT3, function in modulating KSHV ORF57 expression...
  39. Tan J, Price P, Gut I, Stacey M, Warrington N, Wallace H. Characterization of tumor necrosis factor-? block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients. Hum Immunol. 2010;71:1214-9 pubmed publisher
    ..FV16 appears to be the best MHC and TNF block marker of susceptibility. After disease onset, an individual's TNF block haplotype does not modulate CVLU severity. ..
  40. Shichi D, Kikkawa E, Ota M, Katsuyama Y, Kimura A, Matsumori A, et al. The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy. Tissue Antigens. 2005;66:200-8 pubmed
    ..This marked difference in the MHC-related disease susceptibility for HCV- associated cardiomyopathy strongly suggests that the development of HCV- DCM and HCV-HCM is under the control of different pathogenic mechanisms. ..
  41. Sørensen B, Ehrnsberger H, Esposito S, Pfab A, Bruckmann A, Hauptmann J, et al. The Arabidopsis THO/TREX component TEX1 functionally interacts with MOS11 and modulates mRNA export and alternative splicing events. Plant Mol Biol. 2017;93:283-298 pubmed publisher
    ..In addition to the RNA helicase UAP56 and the mRNA export factors ALY2-4 and MOS11 we detected interactions with the mRNA export complex TREX-2 and ..
  42. Thomas M, Sonntag E, Müller R, Schmidt S, Zielke B, Fossen T, et al. pUL69 of Human Cytomegalovirus Recruits the Cellular Protein Arginine Methyltransferase 6 via a Domain That Is Crucial for mRNA Export and Efficient Viral Replication. J Virol. 2015;89:9601-15 pubmed publisher
    ..facilitating the cytoplasmic accumulation of unspliced RNA via interaction with the cellular mRNA export factor UAP56. Here we provide evidence for a posttranslational modification of pUL69 via arginine methylation within the ..
  43. Chang C, Hautbergue G, Walsh M, Viphakone N, van Dijk T, Philipsen S, et al. Chtop is a component of the dynamic TREX mRNA export complex. EMBO J. 2013;32:473-86 pubmed publisher
    ..complex couples nuclear pre-mRNA processing with mRNA export and contains multiple protein components, including Uap56, Alyref, Cip29 and the multi-subunit THO complex. Here, we have identified Chtop as a novel TREX component...
  44. Pfaff C, Ehrnsberger H, Flores Tornero M, Sørensen B, Schubert T, Längst G, et al. ALY RNA-Binding Proteins Are Required for Nucleocytosolic mRNA Transport and Modulate Plant Growth and Development. Plant Physiol. 2018;177:226-240 pubmed publisher
    ..ALY proteins interact with the RNA helicase UAP56, indicating a link to the mRNA export machinery...
  45. Peelman L, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, et al. The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family. Genomics. 1995;26:210-8 pubmed
    The BAT1 gene has previously been identified about 30 kb upstream from the tumor necrosis factor (TNF) locus and close to a NF kappa b-related gene of the nuclear factor family in the major histocompatibility complex (MHC) of human, mouse,..
  46. Migita O, Noguchi E, Koga M, Jian Z, Shibasaki M, Migita T, et al. Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. Clin Exp Allergy. 2005;35:790-6 pubmed
    ..Methods We screened for mutations in the coding and promoter regions of genes in the TNF-LTA region, including BAT1, NFKBIL1, LTA, TNF, LTB, AIF, and BAT2, and conducted a transmission disequilibrium test of 41 polymorphisms in 137 ..
  47. Mizoguchi K, Cha S, Chairoungdua A, Kim D, Shigeta Y, Matsuo H, et al. Human cystinuria-related transporter: localization and functional characterization. Kidney Int. 2001;59:1821-33 pubmed
    ..Although the mutations of the recently identified transporter BAT1/b(0,+)AT have been related to nontype I cystinuria, the function and localization of human BAT1 (hBAT1)/b(0,+)AT ..
  48. Chairoungdua A, Segawa H, Kim J, Miyamoto K, Haga H, Fukui Y, et al. Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein. J Biol Chem. 1999;274:28845-8 pubmed
    ..The transporter designated BAT1 (b(0, +)-type amino acid transporter 1) from rat kidney was found to be structurally related to recently identified ..
  49. Paternoster L, Standl M, Chen C, Ramasamy A, Bønnelykke K, Duijts L, et al. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet. 2011;44:187-92 pubmed publisher
    ..5 (rs7927894; P = 0.008) and 20q13.33 (rs6010620; P = 0.002). Our results underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis. ..
  50. Hu Y, Gor V, Morikawa K, Nagata K, Kawaguchi A. Cellular splicing factor UAP56 stimulates trimeric NP formation for assembly of functional influenza viral ribonucleoprotein complexes. Sci Rep. 2017;7:14053 pubmed publisher
    ..b>UAP56, a cellular splicing factor, functions as a molecular chaperone for NP and is required for the replication-coupled ..
  51. Colgan K, Boyne J, Whitehouse A. Uncoupling of hTREX demonstrates that UAP56 and hTHO-complex recruitment onto herpesvirus saimiri intronless transcripts is required for replication. J Gen Virol. 2009;90:1455-60 pubmed publisher
    ..Herein, we extend these studies and demonstrate that ORF57 recruits several members of hTREX, namely Aly, UAP56 and hTHO-complex proteins, onto the viral mRNAs to assemble an export-competent ribonucleoprotein particle...
  52. Bittencourt I, Serpeloni M, Hiraiwa P, de Arruda Campos Brasil de Souza T, Avila A. Dissecting biochemical peculiarities of the ATPase activity of TcSub2, a component of the mRNA export pathway in Trypanosoma cruzi. Int J Biol Macromol. 2017;98:793-801 pubmed publisher
    The RNA helicase DEAD-box protein Sub2 (yeast)/UAP56 (mammals) is conserved across eukaryotes and is essential for mRNA export in trypanosomes...
  53. McCracken S, Longman D, Johnstone I, Caceres J, Blencowe B. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. J Biol Chem. 2003;278:44153-60 pubmed
    ..The EJC components RNPS1, REF, UAP56, and Y14 interact with SRm160...
  54. Domínguez Sánchez M, Barroso S, Gómez González B, Luna R, Aguilera A. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. PLoS Genet. 2011;7:e1002386 pubmed publisher
  55. Eike M, Olsson M, Undlien D, Dahl Jørgensen K, Joner G, Rønningen K, et al. Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families. Genes Immun. 2009;10:141-50 pubmed publisher
    ..Our results illustrate the importance of a comprehensive adjustment for LD effects when performing association studies in this complex. ..
  56. Cui X, Han W, Li J, Feng R, Zhou Z, Han J, et al. Heat shock factor 4 regulates the expression of HSP25 and alpha B-crystallin by associating with DEXD/H-box RNA helicase UAP56. Cell Stress Chaperones. 2018;23:571-579 pubmed publisher
    ..Using yeast two hybrid, we found that HSF4 interacts with the ATP-dependent DEXD/H-box RNA helicase UAP56, and their interaction in lens epithelial cell line was further confirmed by GST-pull down assay...
  57. Nakata D, Nakao S, Nakayama K, Araki S, Nakayama Y, Aparicio S, et al. The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation. Biochem Biophys Res Commun. 2017;483:271-276 pubmed publisher
    ..This screen identified DDX39B as a regulator of AR-V7 mRNA expression...
  58. Sahni A, Wang N, Alexis J. UAP56 is an important regulator of protein synthesis and growth in cardiomyocytes. Biochem Biophys Res Commun. 2010;393:106-10 pubmed publisher
    b>UAP56, an ATP dependent RNA helicase that also has ATPase activity, is a DExD/H box protein that is phylogenetically grouped with the eukaryotic initiation factor eIF4A, the prototypical member of the DExD/H box family of helicases...
  59. Mendonça V, Souza L, Garcia G, Magalhães B, Lacerda M, Andrade B, et al. DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria. Malar J. 2014;13:278 pubmed publisher
    b>DDX39B (BAT1) encodes an RNA helicase known to regulate expression of TNF and IL-6. Elevated levels of these two cytokines are associated with increased severity of clinical malaria...
  60. Wisskirchen C, Ludersdorfer T, Müller D, Moritz E, Pavlovic J. The cellular RNA helicase UAP56 is required for prevention of double-stranded RNA formation during influenza A virus infection. J Virol. 2011;85:8646-55 pubmed publisher
    The cellular DEAD box RNA helicase UAP56 plays a pivotal role in the efficient transcription/replication of influenza A virus...
  61. Zielke B, Thomas M, Giede Jeppe A, M ller R, Stamminger T. Characterization of the betaherpesviral pUL69 protein family reveals binding of the cellular mRNA export factor UAP56 as a prerequisite for stimulation of nuclear mRNA export and for efficient viral replication. J Virol. 2011;85:1804-19 pubmed publisher
    ..we had reported recently that nucleocytoplasmic shuttling and interaction with the cellular DExD/H-box helicases UAP56 and URH49 were prerequisites for the nuclear-mRNA export activity of pUL69, the homologs were characterized with ..
  62. Shen H. UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear export. BMB Rep. 2009;42:185-8 pubmed
    ..The splicing and export processes are coupled. UAP56 protein, which is ubiquitously present in organisms from yeasts to humans, is a DExD/H-box family RNA helicase ..
  63. Taniguchi I, Mabuchi N, Ohno M. HIV-1 Rev protein specifies the viral RNA export pathway by suppressing TAP/NXF1 recruitment. Nucleic Acids Res. 2014;42:6645-58 pubmed publisher
    ..Thus, Rev controls the identity of the factor occupying the cap-proximal region that determines the RNA export pathway. This ribonucleoprotein remodeling activity of Rev may favor viral gene expression. ..
  64. Tohkin M, Kaniwa N, Saito Y, Sugiyama E, Kurose K, Nishikawa J, et al. A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Pharmacogenomics J. 2013;13:60-9 pubmed publisher
    ..The strongest association was found at rs2734583 in BAT1, rs3094011 in HCP5 and GA005234 in MICC (P=2.44 × 10(-8); odds ratio=66.8; 95% confidence interval, 19.8-225.0)...
  65. Spies T, Blanck G, Bresnahan M, Sands J, Strominger J. A new cluster of genes within the human major histocompatibility complex. Science. 1989;243:214-7 pubmed
    ..The presence of the genes for BAT1 and BAT5 in the vicinity of HLA-B again raises the question of which gene in this region determines susceptibility ..
  66. Kawaguchi A, Momose F, Nagata K. Replication-coupled and host factor-mediated encapsidation of the influenza virus genome by viral nucleoprotein. J Virol. 2011;85:6197-204 pubmed
    ..However, we found that a previously identified cellular protein, RAF-2p48/NPI-5/UAP56, facilitates replication reaction-coupled encapsidation as an NP molecular chaperone...
  67. Affandi J, Price P, Imran D, Yunihastuti E, Djauzi S, Cherry C. Can we predict neuropathy risk before stavudine prescription in a resource-limited setting?. AIDS Res Hum Retroviruses. 2008;24:1281-4 pubmed publisher
    ..DNA from saliva was used to examine alleles of TNFA-308, BAT1 (intron 10), TNFA-1031, IL1A+4845, and IL12B (3' UTR). The prevalence of neuropathy (symptoms and signs) was 34%...
  68. Hammer S, Avalos J. Uncovering the role of branched-chain amino acid transaminases in Saccharomyces cerevisiae isobutanol biosynthesis. Metab Eng. 2017;44:302-312 pubmed publisher
    ..uncover and characterize two competing isobutanol pathways, which can be manipulated by overexpressing or deleting BAT1 or BAT2, and adding or removing valine from the fermentation media...
  69. Thomas M, Lischka P, Müller R, Stamminger T. The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity. PLoS ONE. 2011;6:e22671 pubmed publisher
    ..The closely related human proteins UAP56 and URH49 are members of this protein family and play an essential role for cellular mRNA export by recruiting the ..
  70. González J, López G, Argueta S, Escalera Fanjul X, El Hafidi M, Campero Basaldua C, et al. Diversification of Transcriptional Regulation Determines Subfunctionalization of Paralogous Branched Chain Aminotransferases in the Yeast Saccharomyces cerevisiae. Genetics. 2017;207:975-991 pubmed publisher
    i>Saccharomyces cerevisiae harbors BAT1 and BAT2 paralogous genes that encode branched chain aminotransferases and have opposed expression profiles and physiological roles ...
  71. Koch W, Hoppmann P, Michou E, Jung V, Pfeufer A, Müller J, et al. TaqMan assays for genotyping of single nucleotide polymorphisms present at a disease susceptibility locus on chromosome 6. Clin Chem Lab Med. 2005;43:167-72 pubmed
    Multiple single-nucleotide polymorphisms in the BAT1-NFKBIL1-LTA region on the short arm of chromosome 6 have been found to be associated with susceptibility to myocardial infarction in a recent case-control study including individuals ..
  72. Shi H, Cordin O, Minder C, Linder P, Xu R. Crystal structure of the human ATP-dependent splicing and export factor UAP56. Proc Natl Acad Sci U S A. 2004;101:17628-33 pubmed
    ..The highly conserved DECD-box protein UAP56/Sub2 is an essential splicing factor that is also important for mRNA export...
  73. Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, et al. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). J Infect Dis. 2009;199:419-26 pubmed publisher
    ..02x10(-19)) and identified several new associations, all of them involving HLA genes: MICB, TNF, RDBP, BAT1-5, PSORS1C1, and HLA-C...
  74. Chi B, Wang Q, Wu G, Tan M, Wang L, Shi M, et al. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. Nucleic Acids Res. 2013;41:1294-306 pubmed publisher
    The mRNA export complex TREX (TREX) is known to contain Aly, UAP56, Tex1 and the THO complex, among which UAP56 is required for TREX assembly...
  75. Ota M, Katsuyama Y, Kimura A, Tsuchiya K, Kondo M, Naruse T, et al. A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region. Genomics. 2001;71:263-70 pubmed
    ..In this critical segment, four expressed genes have been thus far identified, NFKBIL1 (IkappaBL), ATP6G, BAT1, and MICB, all of which are candidate genes for determining susceptibility to RA...
  76. Banerjee A, Sammarco M, Ditch S, Grabczyk E. A dual reporter approach to quantify defects in messenger RNA processing. Anal Biochem. 2009;395:237-43 pubmed publisher
    ..We demonstrate the sensitivity of our construct to defects in nuclear export by depleting UAP56 and NXF1, essential components of the cotranscriptional machinery.
  77. Ortiz D, St Pierre M, Abdulmessih A, Arias I. A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport. J Biol Chem. 1997;272:15358-65 pubmed
    ..The BAT1 (bile acid transporter) gene was isolated from yeast DNA by polymerase chain reaction amplification using ..