DDX17

Summary

Gene Symbol: DDX17
Description: DEAD-box helicase 17
Alias: P72, RH70, DEAD (Asp-Glu-Ala-Asp) box helicase 17, DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, DEAD box protein p72, DEAD box protein p82, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD), RNA-dependent helicase p72
Species: human
Products:     DDX17

Top Publications

  1. Uhlmann Schiffler H, Rössler O, Stahl H. The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicase. J Biol Chem. 2002;277:1066-75 pubmed
    p68 and p72 are two highly related DEAD box proteins with similar biochemical activities in the nucleus of vertebrate cells; it is unknown whether they have redundant or differential in vivo functions...
  2. Honig A, Auboeuf D, Parker M, O Malley B, Berget S. Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72. Mol Cell Biol. 2002;22:5698-707 pubmed
    ..Here, we show that the abundant DEAD-box RNA helicase p72, but not its close relative p68, affects the splicing of alternative exons containing AC-rich exon enhancer ..
  3. Germann S, Gratadou L, Zonta E, Dardenne E, Gaudineau B, Fougere M, et al. Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor. Oncogene. 2012;31:4536-49 pubmed publisher
    Ddx5 and ddx17 are two highly related RNA helicases involved in both transcription and splicing. These proteins coactivate transcription factors involved in cancer such as the estrogen receptor alpha, p53 and beta-catenin...
  4. Wortham N, Ahamed E, Nicol S, Thomas R, Periyasamy M, Jiang J, et al. The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. Oncogene. 2009;28:4053-64 pubmed publisher
    The DEAD-box RNA helicases p68 (DDX5) and p72 (DDX17) have been shown to act as transcriptional co-activators for a diverse range of transcription factors, including oestrogen receptor-alpha (ERalpha)...
  5. Wong H, Demmers J, Bezstarosti K, Grootegoed J, Brinkmann A. DNA dependent recruitment of DDX17 and other interacting proteins by the human androgen receptor. Biochim Biophys Acta. 2009;1794:193-8 pubmed publisher
    ..One of these proteins, DDX17, is known to be a co-factor for estrogen receptor alpha (ERalpha), but has never been associated with AR function...
  6. Dardenne E, Pierredon S, Driouch K, Gratadou L, Lacroix Triki M, Espinoza M, et al. Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat Struct Mol Biol. 2012;19:1139-46 pubmed publisher
    ..Here, we report that the mouse and human RNA helicases Ddx17 and Ddx5 contribute to tumor-cell invasiveness by regulating alternative splicing of several DNA- and chromatin-..
  7. Lee C. RH70, a bidirectional RNA helicase, co-purifies with U1snRNP. J Biol Chem. 2002;277:39679-83 pubmed
    ..Peptide sequence analysis by mass spectrometry and Edman degradation revealed that RH70 is the previously reported DDX17. Biochemical characterization of RH70, obtained by partial separation from U1snRNP, yielded the following results...
  8. Ogilvie V, Wilson B, Nicol S, Morrice N, Saunders L, Barber G, et al. The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells. Nucleic Acids Res. 2003;31:1470-80 pubmed
    The RNA helicases p68 and p72 are highly related members of the DEAD box family of proteins, sharing 90% identity across the conserved core, and have been shown to be involved in both transcription and mRNA processing...
  9. Shin S, Janknecht R. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. J Cell Biochem. 2007;101:1252-65 pubmed
    ..In particular, very little is known about the role of p72 RNA helicase in gene regulation. Here, we have analyzed how this helicase may enhance promoter activity...

More Information

Publications91

  1. Lamm G, Nicol S, Fuller Pace F, Lamond A. p72: a human nuclear DEAD box protein highly related to p68. Nucleic Acids Res. 1996;24:3739-47 pubmed
    b>P72, a novel human member of the DEAD box family of putative RNA-dependent ATPases and ATP-dependent RNA helicases was isolated from a HeLa cDNA library...
  2. Wilson B, Bates G, Nicol S, Gregory D, Perkins N, Fuller Pace F. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. BMC Mol Biol. 2004;5:11 pubmed
    p68 (Ddx5) and p72 (Ddx17) are highly related members of the DEAD box family and are established RNA helicases. They have been implicated in growth regulation and have been shown to be involved in both pre-mRNA and pre-rRNA processing...
  3. Bates G, Nicol S, Wilson B, Jacobs A, Bourdon J, Wardrop J, et al. The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. EMBO J. 2005;24:543-53 pubmed
    ..This study represents the first report of the involvement of an RNA helicase in the p53 response, and highlights a novel mechanism by which p68 may act as a tumour cosuppressor in governing p53 transcriptional activity. ..
  4. Caretti G, Schiltz R, Dilworth F, Di Padova M, Zhao P, Ogryzko V, et al. The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. Dev Cell. 2006;11:547-60 pubmed
    ..We have found that the RNA helicases p68/p72 are MyoD-associated proteins and that the noncoding RNA SRA also immunoprecipitates with MyoD...
  5. Mestre Fos S, Penev P, Suttapitugsakul S, Ito C, Petrov A, Wartell R, et al. G-Quadruplexes in Human Ribosomal RNA. J Mol Biol. 2019;: pubmed publisher
    ..to identify proteins that bind to rRNA G-quadruplexes in cell lysates, which include helicases (DDX3, CNBP, DDX21, DDX17) and heterogeneous nuclear ribonucleoproteins (hnRNPs)...
  6. Sunwoo S, Pérez Núñez D, Morozov I, Sánchez E, Gaudreault N, Trujillo J, et al. DNA-Protein Vaccination Strategy Does Not Protect from Challenge with African Swine Fever Virus Armenia 2007 Strain. Vaccines (Basel). 2019;7: pubmed publisher
    ..Pigs were vaccinated three times with a cocktail that included ASFV plasmid DNA (CD2v, p72, p32, +/-p17) and recombinant proteins (p15, p35, p54, +/-p17)...
  7. Hitachi K, Nakatani M, Takasaki A, Ouchi Y, Uezumi A, Ageta H, et al. Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation. EMBO Rep. 2019;20: pubmed publisher
    ..Mechanistically, Myoparr interacts with Ddx17, a transcriptional coactivator of MyoD, and regulates the association between Ddx17 and the histone ..
  8. Leblanc N, Cortey M, Fernandez Pinero J, Gallardo C, Masembe C, Okurut A, et al. Development of a suspension microarray for the genotyping of African swine fever virus targeting the SNPs in the C-terminal end of the p72 gene region of the genome. Transbound Emerg Dis. 2013;60:378-83 pubmed publisher
    ..Previous studies have identified the 22 genotypes based on sequence variation in the C-terminal region of the p72 gene, which has become the standard for categorizing ASFVs...
  9. Urbanek Trzeciak M, Jaworska E, Krzyzosiak W. miRNAmotif-A Tool for the Prediction of Pre-miRNA⁻Protein Interactions. Int J Mol Sci. 2018;19: pubmed publisher
    ..and DGCR8 and predicting motifs within pre-miRNA precursors that are recognized by two DEAD-box helicases-DDX1 and DDX17. miRNAmotif is released as an open-source software under the MIT License. The code is available at GitHub (www...
  10. Murgia M, Mogler M, Certoma A, Green D, Monaghan P, Williams D, et al. Evaluation of an African swine fever (ASF) vaccine strategy incorporating priming with an alphavirus-expressed antigen followed by boosting with attenuated ASF virus. Arch Virol. 2019;164:359-370 pubmed publisher
    ..Alphavirus RPs expressing ASFV p30 (RP-30), p54 (RP-54) or pHA-72 (RP-sHA-p72) antigens were constructed and tested for expression in Vero cells and for immunogenicity in pigs...
  11. Gunaratna R, Santos A, Luo L, Nagi C, Lambertz I, Spier M, et al. Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model. Oncogene. 2019;: pubmed publisher
    ..Human epidemiological studies reveal that a p53 single-nucleotide polymorphism (SNP) at codon 72, encoding proline (P72) or arginine (R72), is associated with differential risk of several cancers, including BrCa...
  12. Skibinski D, Jones L, Zhu Y, Xue L, Au B, Lee B, et al. Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine. Sci Rep. 2018;8:18007 pubmed publisher
    ..A transcriptional signature to vaccination was found to correlate with antibody titer, IFN-γ production by T-cells and expression of a putative RNA helicase, DDX17, on the surface of immune cells.
  13. Dei Giudici S, Franzoni G, Bonelli P, Bacciu D, Sanna G, Angioi P, et al. Interaction of historical and modern Sardinian African swine fever viruses with porcine and wild-boar monocytes and monocyte-derived macrophages. Arch Virol. 2019;164:739-745 pubmed publisher
    ..Higher intracellular levels of the late protein p72 were detected after infection with the modern strain 22653/14 compared to the historical strain Nu81...
  14. Muangkram Y, Sukmak M, Wajjwalku W. Phylogeographic analysis of African swine fever virus based on the p72 gene sequence. Genet Mol Res. 2015;14:4566-74 pubmed publisher
    ..This study established a novel phylogenetic analysis and epidemiology comparison based on 205 bp of p72 gene sequences...
  15. Chiou E, Zennadi R. Gαs proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-αvβ3 and CD44-CD44 interactions. Int J Biochem Cell Biol. 2015;65:40-51 pubmed publisher
    ..This effect involved the non-receptor tyrosine kinases, p72(Syk) and p60-c-Src, which were more abundant in SSRBCs than in normal erythrocytes...
  16. Rajendran D, Zhang Y, Berry D, McGlade C. Regulation of Numb isoform expression by activated ERK signaling. Oncogene. 2016;35:5202-13 pubmed publisher
    ..AS of coding exon 9 (E9) produces E9-included (p72/p71) and -excluded (p66/p65) protein products...
  17. Simulundu E, Sinkala Y, Chambaro H, Chinyemba A, Banda F, Mooya L, et al. Genetic characterisation of African swine fever virus from 2017 outbreaks in Zambia: Identification of p72 genotype II variants in domestic pigs. Onderstepoort J Vet Res. 2018;85:e1-e5 pubmed publisher
  18. Alkhamis M, Gallardo C, Jurado C, Soler A, Arias M, Sánchez Vizcaíno J. Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa. PLoS ONE. 2018;13:e0192565 pubmed publisher
    ..We illustrated the prospects of phylodynamic methods in improving risk-based surveillance, support of effective animal health policies, and epidemic preparedness in countries at high risk of ASFV incursion. ..
  19. Lambert M, Terrone S, Giraud G, Benoit Pilven C, Cluet D, Combaret V, et al. The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation. Nucleic Acids Res. 2018;46:7686-7700 pubmed publisher
    ..Here, we report that the DEAD box RNA helicase DDX17 controls important REST-related processes that are critical during the early phases of neuronal differentiation...
  20. Koo C, Kobiyama K, Shen Y, LeBert N, Ahmad S, Khatoo M, et al. RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression. J Biol Chem. 2015;290:7463-73 pubmed publisher
    ..RNA:DNA hybrids bind to several components of the microRNA (miRNA) machinery-related proteins, including AGO2 and DDX17. Furthermore, we identified miRNAs that are specifically regulated by Pol III, providing a potential link between ..
  21. Bishop R, Fleischauer C, de Villiers E, Okoth E, Arias M, Gallardo C, et al. Comparative analysis of the complete genome sequences of Kenyan African swine fever virus isolates within p72 genotypes IX and X. Virus Genes. 2015;50:303-9 pubmed publisher
    ..We describe genome sequencing and annotation of a recent pig-derived p72 genotype IX, and a tick-derived genotype X isolate from Kenya using the Illumina platform and comparison with the ..
  22. Ismael H, Altmeyer S, Stahl H. Regulation of the U3-, U8-, and U13snoRNA Expression by the DEAD Box Proteins Ddx5/Ddx17 with Consequences for Cell Proliferation and Survival. Noncoding RNA. 2016;2: pubmed publisher
    ..significant increase in the concentrations of U3-, U8-, and U13snoRNA after a knockdown of DEAD box proteins Ddx5/Ddx17 in HeLa cells is observed...
  23. Portugal R, Coelho J, Höper D, Little N, Smithson C, Upton C, et al. Related strains of African swine fever virus with different virulence: genome comparison and analysis. J Gen Virol. 2015;96:408-19 pubmed publisher
    ..Phylogenetic analysis grouped L60 and NHV closest to other P72 genotype I ASFV strains from Europe and West Africa, consistent with the assumed West African origin of all ..
  24. Kung C, Khaku S, Jennis M, Zhou Y, Murphy M. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. Mol Cancer Res. 2015;13:250-62 pubmed publisher
    ..Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53 function...
  25. Boshoff C, Bastos A, Dube M, Heath L. First molecular assessment of the African swine fever virus status of Ornithodoros ticks from Swaziland. Onderstepoort J Vet Res. 2014;81:E1-5 pubmed publisher
    ..for virus genome presence using a duplex Polymerase Chain Reaction (PCR) that targets the C-terminal end of the p72 gene of the ASFV and confirms DNA integrity through amplification of the 16S rRNA tick host gene...
  26. Sithole N, Williams C, Vaughan A, Kenyon J, Lever A. DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV. J Mol Biol. 2018;430:3111-3128 pubmed publisher
    ..We show that DDX17, but not its close paralog DDX5, specifically controls the usage of this splice acceptor group...
  27. Chu Y, Chen H, Huang T, Chan S. A novel function for the DEAD-box RNA helicase DDX-23 in primary microRNA processing in Caenorhabditis elegans. Dev Biol. 2016;409:459-72 pubmed publisher
    ..In humans, this process is known to be facilitated by the DEAD-box helicases p68 (DDX5) and p72 (DDX17). In this study, we performed a candidate-based RNAi screen in C...
  28. Chen X, Yang J, Ji Y, Okoth E, Liu B, Li X, et al. Recombinant Newcastle disease virus expressing African swine fever virus protein 72 is safe and immunogenic in mice. Virol Sin. 2016;31:150-9 pubmed publisher
    ..In this study, we generated a recombinant Newcastle disease virus (rNDV) expressing ASFV protein 72 (p72) by reverse genetics and evaluated its humoral and cellular immunogenicity in a mouse model...
  29. Le Sage V, Cinti A, Valiente Echeverría F, Mouland A. Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation. Virol J. 2015;12:138 pubmed publisher
    ..of the hits identified in the BioID screen were validated by immunoprecipation and confirmed the interaction of DDX17 and RPS6 with HIV-1 Gag...
  30. Thoromo J, Simulundu E, Chambaro H, Mataa L, Lubaba C, Pandey G, et al. Diagnosis and genotyping of African swine fever viruses from 2015 outbreaks in Zambia. Onderstepoort J Vet Res. 2016;83:a1095 pubmed publisher
    ..Molecular diagnosis by polymerase chain reaction targeting specific amplification of p72 (B646L) gene of ASF virus (ASFV) was conducted...
  31. Portugal R, Bauer A, Keil G. Selection of differently temporally regulated African swine fever virus promoters with variable expression activities and their application for transient and recombinant virus mediated gene expression. Virology. 2017;508:70-80 pubmed publisher
    ..We therefore compared the capacities of putative promoter sequences from p72, CD2v, p30, viral DNA polymerase and U104L genes to mediate expression of luciferase from transfected plasmids ..
  32. Triozzi P, Achberger S, Aldrich W, Crabb J, Saunthararajah Y, Singh A. Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma. Clin Epigenetics. 2016;8:80 pubmed publisher
    ..Tumors manifesting monosomy-3 were also characterized by higher levels of TARBP2 and DDX17 and by lower levels of XPO5 and HIWI, miR biogenesis factors...
  33. Emerson J, Bartholomai B, Ringelberg C, Baker S, Loros J, Dunlap J. period-1 encodes an ATP-dependent RNA helicase that influences nutritional compensation of the Neurospora circadian clock. Proc Natl Acad Sci U S A. 2015;112:15707-12 pubmed publisher
    ..PRD-1 is an RNA helicase whose orthologs, DDX5 [DEAD (Asp-Glu-Ala-Asp) Box Helicase 5] and DDX17 in humans and DBP2 (Dead Box Protein 2) in yeast, are implicated in various processes, including transcriptional ..
  34. Lin B, Wang F, Wang J, Xu C, Zhao H, Cheng Z, et al. The protective role of p72 in doxorubicin?induced cardiomyocytes injury in vitro. Mol Med Rep. 2016;14:3376-80 pubmed publisher
    p72 (probable ATP-dependent RNA helicase DDX17) belongs to the DEAD?box RNA helicase family. p72 is important in RNA processing...
  35. Kung C, Leu J, Basu S, Khaku S, Anokye Danso F, Liu Q, et al. The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction. Cell Rep. 2016;14:2413-25 pubmed publisher
    ..p53 developed more-severe obesity and glucose intolerance on a HFD, compared to mice with the proline 72 variant (P72)...
  36. Fletcher C, Godfrey J, Shibakawa A, Bushell M, Bevan C. A novel role for GSK3? as a modulator of Drosha microprocessor activity and MicroRNA biogenesis. Nucleic Acids Res. 2016;: pubmed
    ..GSK3? achieves this through promoting Drosha:cofactor and Drosha:pri-miR interactions: it binds to DGCR8 and p72 in the Microprocessor, an effect dependent upon presence of RNA...
  37. Szczurowska E, Ergang P, Kubová H, Druga R, Salaj M, Mareš P. Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors. Exp Neurol. 2016;283:97-109 pubmed publisher
    ..e. at P12, P15, P18, P25, P72 respectively)...
  38. Wei L, Wang Y, Chang Y, An N, Wang X, Zhou P, et al. Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing. Am J Cancer Res. 2018;8:226-244 pubmed
    ..Mechanistically, enhanced oncogenic Yes associated protein (YAP) nuclear translocation mediates sequestration of p72, a co-factor of the Drosha/DGCR8 complex for pri-miR-7s processing, leading to attenuation of microprocessors' ..
  39. Remenyi J, Bajan S, Fuller Pace F, Arthur J, Hutvagner G. The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132. Sci Rep. 2016;6:22848 pubmed publisher
    ..The DEAD box helicase p72/DDX17 was identified as a factor that facilitates the specific processing of miR-132.
  40. Torres L, Garcia R, Blois A, Dati L, Durão A, Alves A, et al. Exposure of Neonatal Mice to Tobacco Smoke Disturbs Synaptic Proteins and Spatial Learning and Memory from Late Infancy to Early Adulthood. PLoS ONE. 2015;10:e0136399 pubmed publisher
    ..memory were evaluated in the Morris water maze during infancy (P20-P29), adolescence (P37-P42) and adulthood (P67-P72)...
  41. Lopera Madrid J, Osorio J, He Y, Xiang Z, Adams L, Laughlin R, et al. Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine. Vet Immunol Immunopathol. 2017;185:20-33 pubmed publisher
    ..Three HEK-purified antigens [B646L (p72), E183L (p54), and O61R (p12)], and three MVA-vectored antigens [B646L, EP153R, and EP402R (CD2v)] were evaluated ..
  42. Priyanka -, Agrawal T, Kotasthane A, Kosharia A, Kushwah R, Zaidi N, et al. Crop specific plant growth promoting effects of ACCd enzyme and siderophore producing and cynogenic fluorescent Pseudomonas. 3 Biotech. 2017;7:27 pubmed publisher
    ..crop specific plant growth stimulation exerted by different fluorescent Pseudomonas was observed on wheat (P124), chickpea (P72), lathyrus (P85, P216), greengram (P11), blackgram (P99, P233); bottlegourd (P248, P167); rice (P176, P247).
  43. Erazo A, Goff S. Nuclear matrix protein Matrin 3 is a regulator of ZAP-mediated retroviral restriction. Retrovirology. 2015;12:57 pubmed publisher
    ..analysis of Matrin 3-associated proteins uncovered interactions with proteins of the ZAP degradation complex, DDX17 and EXOSC3...
  44. Mulumba Mfumu L, Achenbach J, Mauldin M, Dixon L, Tshilenge C, Thiry E, et al. Genetic Assessment of African Swine Fever Isolates Involved in Outbreaks in the Democratic Republic of Congo between 2005 and 2012 Reveals Co-Circulation of p72 Genotypes I, IX and XIV, Including 19 Variants. Viruses. 2017;9: pubmed publisher
    ..2005-2012, were examined for viral DNA and sequencing at multiple loci: C-terminus of the B646L gene (p72 protein), central hypervariable region (CVR) of the B602L gene, and the E183L gene (p54 protein)...
  45. Nel M, Jalali Sefid Dashti M, Gamieldien J, Heckmann J. Exome sequencing identifies targets in the treatment-resistant ophthalmoplegic subphenotype of myasthenia gravis. Neuromuscul Disord. 2017;27:816-825 pubmed publisher
    ..Validation in 25 OP-MG and 50 control-MG cases supported the association of DDX17delG (p = 0.014) and SPTLC3insACAC (p = 0...
  46. Crisci A, Raleff F, Bagdiul I, Raabe M, Urlaub H, Rain J, et al. Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins. Nucleic Acids Res. 2015;43:10456-73 pubmed publisher
    ..In addition, these findings may have implications for alternative splicing decisions. ..
  47. Sithole N, Williams C, Vaughan A, Lever A. The roles of DEAD box helicases in the life cycle of HIV-1. Lancet. 2015;385 Suppl 1:S89 pubmed publisher
    ..We went on to study two of them in detail, the very closely related DDX5 and DDX17. We confirmed that knocking down DDX5 reduced HIV RNA and consequently viral production as measured by CA-p24 (..
  48. Moy R, Cole B, Yasunaga A, Gold B, Shankarling G, Varble A, et al. Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Cell. 2014;158:764-777 pubmed publisher
    ..RNAi screening, we identify an evolutionarily conserved and interferon-independent role for the DEAD-box helicase DDX17 in restricting Rift Valley fever virus (RVFV), a mosquito-transmitted virus in the bunyavirus family that causes ..
  49. Chen S, Xu Y, Zhang K, Wang X, Sun J, Gao G, et al. Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA. Nat Struct Mol Biol. 2012;19:430-5 pubmed publisher
    ..ZAP molecules interact to form a dimer that binds to a ZAP-responsive RNA molecule containing two ZAP-binding modules. These results provide insights into how ZAP binds specifically to complex target RNA. ..
  50. Tonevitsky E, Trushkin E, Shkurnikov M, Akimov E, Sakharov D. Changed profile of splicing regulator genes expression in response to exercise. Bull Exp Biol Med. 2009;147:733-6 pubmed
    ..increase of mRNA expression of genes encoding proteins involved in the formation of precatalytic splisosome: DDX17, DDX46, HNRNPR, PRPF4B, and SRPK2...
  51. Nicol S, Causevic M, Prescott A, Fuller Pace F. The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase. Exp Cell Res. 2000;257:272-80 pubmed
  52. Williams C, Abbink T, Jeang K, Lever A. Identification of RNA helicases in human immunodeficiency virus 1 (HIV-1) replication - a targeted small interfering RNA library screen using pseudotyped and WT HIV-1. J Gen Virol. 2015;96:1484-9 pubmed publisher
    ..were identified which, when knocked down, reproducibly decreased infectious particle production: DDX5, DDX10, DDX17, DDX28 and DDX52. Two of these proteins (DDX5 and DDX17) have known roles in HIV-1 replication...
  53. Fujita T, Kobayashi Y, Wada O, Tateishi Y, Kitada L, Yamamoto Y, et al. Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. J Biol Chem. 2003;278:26704-14 pubmed
    ..revealed that whereas 4-hydroxytamoxifen (OHT) induced binding of ERalpha to both an AF-1 coactivator complex (p68/p72 and p300) and corepressor complexes (N-CoR/SMRT), BBP selectively enhanced the binding to the AF-1 coactivators...
  54. Shuaib M, Ouararhni K, Dimitrov S, Hamiche A. HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. Proc Natl Acad Sci U S A. 2010;107:1349-54 pubmed publisher
    ..Our data identified HJURP as a vertebrate CENP-A chaperone and dissected its mode of interactions with CENP-A. ..
  55. Garibaldi F, Falcone E, Trisciuoglio D, Colombo T, Lisek K, Walerych D, et al. Mutant p53 inhibits miRNA biogenesis by interfering with the microprocessor complex. Oncogene. 2016;35:3760-70 pubmed publisher
    ..RNA-chromatin immunoprecipitation experiments, we show that endogenous mutp53 binds and sequesters RNA helicases p72/82 from the microprocessor complex, interfering with Drosha-pri-miRNAs association...
  56. Alqahtani H, Gopal K, Gupta N, Jung K, Alshareef A, Ye X, et al. DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer. Cell Signal. 2016;28:42-50 pubmed publisher
    ..In this study, we focused on DDX17, known to be a transcription co-activator and found to be a Sox2 binding partner by liquid chromatography-mass ..
  57. Connerty P, Bajan S, Remenyi J, Fuller Pace F, Hutvagner G. The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells. Biochim Biophys Acta. 2016;1859:1299-305 pubmed publisher
    ..Here we show that the two RNA-binding proteins, p72 and KHSRP, both with known roles in promoting miRNA biogenesis, regulate the protein level of human Ago2 in ..
  58. Paul S, Dansithong W, Jog S, Holt I, Mittal S, Brook J, et al. Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. J Biol Chem. 2011;286:38427-38 pubmed publisher
    ..10 proteins involved in remodeling ribonucleoprotein complexes including hnRNP H, H2, H3, F, A2/B1, K, L, DDX5, DDX17, and DHX9...
  59. Mori M, Triboulet R, Mohseni M, Schlegelmilch K, Shrestha K, Camargo F, et al. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014;156:893-906 pubmed publisher
    ..At low cell density, nuclear YAP binds and sequesters p72 (DDX17), a regulatory component of the miRNA-processing machinery...
  60. Li K, Mo C, Gong D, Chen Y, Huang Z, Li Y, et al. DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin. Cancer Lett. 2017;400:194-202 pubmed publisher
    ..Here, we report that elevated DDX17 levels are observed in gefitinib-resistant NSCLC cells than gefitinib-sensitive cells...
  61. Stellato C, Nassa G, Tarallo R, Giurato G, Ravo M, Rizzo F, et al. Identification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β in human breast cancer cells. Proteomics. 2015;15:1801-7 pubmed publisher
    ..All MS data have been deposited in the ProteomeXchange with identifier PXD001202 (http://proteomecentral.proteomexchange.org/dataset/PXD001202). ..
  62. Onzere C, Bastos A, Okoth E, Lichoti J, Bochere E, Owido M, et al. Multi-locus sequence typing of African swine fever viruses from endemic regions of Kenya and Eastern Uganda (2011-2013) reveals rapid B602L central variable region evolution. Virus Genes. 2018;54:111-123 pubmed publisher
    ..virus (ASFV) is highly polymorphic within the 23 ASFV genotypes defined by sequencing of the C-terminal end of the p72 locus. Sequencing the p54 gene further discriminates ASFV genotypes that are conserved at the p72 locus...
  63. Lemchak D, Banerjee S, Digambar S, Hood B, Conrads T, Jedrych J, et al. Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and sezary syndrome. Exp Dermatol. 2017;: pubmed publisher
    ..heat shock protein family A (Hsp70) member 1 like (HSAP1L), Hsp70 member 1A (HSPA1A), ATP-depending RNA-helicase (DDX17), and the ? isoform of lamina-associated polypeptide 2 (TMPO) had higher expression in aggressive disease versus ..
  64. Luking A, Stahl U, Schmidt U. The protein family of RNA helicases. Crit Rev Biochem Mol Biol. 1998;33:259-96 pubmed
    ..Although RNA helicase activity has only been demonstrated for a few examples yet, it is generally believed that all members of the largest subgroups, the DEAD and DEAH box proteins, exhibit this activity. ..
  65. Yasuda Inoue M, Kuroki M, Ariumi Y. Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function. Biochem Biophys Res Commun. 2013;434:803-8 pubmed publisher
    ..In this study, we noticed that distinct DDX RNA helicases, including DDX1, DDX3, DDX5, DDX17, DDX21, DDX56, except DDX6, bound to the Rev protein and they colocalized with Rev in nucleolus or nucleus...
  66. Wang J, Wang J, Geng Y, Yuan W. A recombinase polymerase amplification-based assay for rapid detection of African swine fever virus. Can J Vet Res. 2017;81:308-312 pubmed
    ..Primers and the exo probe targeting the conserved region of the P72 gene of ASFV were designed and the reaction was run on the Genie III scanner device...
  67. Simulundu E, Lubaba C, Van Heerden J, Kajihara M, Mataa L, Chambaro H, et al. The Epidemiology of African Swine Fever in "Nonendemic" Regions of Zambia (1989-2015): Implications for Disease Prevention and Control. Viruses. 2017;9: pubmed publisher
    ..sequence analysis conducted on genetic data of ASF viruses (ASFVs) detected in domestic pigs revealed that p72 genotypes I, II, VIII and XIV have been involved in causing ASF outbreaks in swine during the study period...
  68. Shiohama A, Sasaki T, Noda S, Minoshima S, Shimizu N. Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins. Exp Cell Res. 2007;313:4196-207 pubmed
    ..Thus, our studies provided additional new evidence for the involvement of various protein complexes in the molecular mechanisms of apparently complex innate RNA interference machinery. ..
  69. Wilson B, Giguere V. Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis. BMC Genomics. 2007;8:419 pubmed
    ..We have used the DEAD-box proteins p68(Ddx5) and p72(Ddx17) as models for this coexpression frequency analysis as there are defined functions for these proteins in splicing ..
  70. Zhang Z, Tian H, Miao Y, Feng X, Li Y, Wang H, et al. Upregulation of p72 Enhances Malignant Migration and Invasion of Glioma Cells by Repressing Beclin1 Expression. Biochemistry (Mosc). 2016;81:574-82 pubmed publisher
    b>p72 is the member of the DEAD-box RNA helicase family, which can unwind double-stranded RNA and is efficient for microRNA (miRNA, miR) processing. However, its specific role in glioma has not been elucidated...
  71. Sanna G, Dei Giudici S, Bacciu D, Angioi P, Giammarioli M, De Mia G, et al. Improved Strategy for Molecular Characterization of African Swine Fever Viruses from Sardinia, Based on Analysis of p30, CD2V and I73R/I329L Variable Regions. Transbound Emerg Dis. 2017;64:1280-1286 pubmed publisher
    ..Previous sequencing data of genes that codify for viral protein p54, p72 and the central variable region (CVR) within the B602L gene revealed that Sardinian isolates show a very low level ..
  72. Sand Dejmek J, Adelmant G, Sobhian B, Calkins A, Marto J, Iglehart D, et al. Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin. Mol Cancer. 2011;10:74 pubmed publisher
    ..Silencing FACT however, allows both apoptosis and necrosis. Targeting DNA repair in cancer patients may have different therapeutic effects depending upon the roles played by factors targeted. ..
  73. Mooney S, Goel A, D Assoro A, Salisbury J, Janknecht R. Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem. 2010;285:30443-52 pubmed publisher
    Here, we demonstrate that p68 (DDX5) and p72 (DDX17), two homologous RNA helicases and transcriptional cofactors, are substrates for the acetyltransferase p300 in vitro and in vivo...
  74. Lorgeoux R, Pan Q, Le Duff Y, Liang C. DDX17 promotes the production of infectious HIV-1 particles through modulating viral RNA packaging and translation frameshift. Virology. 2013;443:384-92 pubmed publisher
    ..Among these helicases, the DEAD-box RNA helicase DDX17 was recently reported to modulate HIV-1 RNA stability and export...
  75. Dardenne E, Polay Espinoza M, Fattet L, Germann S, Lambert M, Neil H, et al. RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell Rep. 2014;7:1900-13 pubmed publisher
    The RNA helicases DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation; however, their in vivo targets and activities in biological processes such as cell ..
  76. Samaan S, Tranchevent L, Dardenne E, Polay Espinoza M, Zonta E, Germann S, et al. The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways. Nucleic Acids Res. 2014;42:2197-207 pubmed publisher
    ..large networks of protein kinases and transcriptional coregulators, including Ddx5 and its highly related paralog Ddx17. The Ddx5 and Ddx17 RNA helicases are also splicing regulators...
  77. Chen G, Guo X, Lv F, Xu Y, Gao G. p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. Proc Natl Acad Sci U S A. 2008;105:4352-7 pubmed publisher
    ..In the present study, we identified the p72 DEAD box RNA helicase, but not the highly similar RNA helicase p68, as a ZAP-interacting protein...
  78. Yang J, Zhao Y, Kalita M, Li X, Jamaluddin M, Tian B, et al. Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases. Mol Cell Proteomics. 2015;14:2701-21 pubmed publisher
    ..These data indicate that CDK9 is a dynamic multifunctional enzyme complex mediating not only transcriptional elongation, but also alternative RNA splicing and potentially translational control. ..
  79. Ponti F, Corsini S, Gnoli M, Pedrini E, Mordenti M, Sangiorgi L. Evaluation of TP53 Pro72Arg and MDM2 SNP285-SNP309 polymorphisms in an Italian cohort of LFS suggestive patients lacking identifiable TP53 germline mutations. Fam Cancer. 2016;15:635-43 pubmed publisher
    ..A strong combined outcome with a 'dosage' effect has also been reported for TP53 P72 and MDM2 SNP309 G allele on cancer susceptibility (p < 0.0005)...
  80. Zhu Y, Chen G, Lv F, Wang X, Ji X, Xu Y, et al. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Proc Natl Acad Sci U S A. 2011;108:15834-9 pubmed publisher
    ..In addition, ZAP recruits cellular decapping complex through its cofactor RNA helicase p72 to initiate degradation of the target viral mRNA from the 5' end...
  81. Mooney S, Grande J, Salisbury J, Janknecht R. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. Biochemistry. 2010;49:1-10 pubmed publisher
    The p68 (DDX5) and p72 (DDX17) proteins are members of the DEAD-box (DDX) family of RNA helicases. We show that both p68 and p72 are overexpressed in breast tumors...
  82. Shin S, Rossow K, Grande J, Janknecht R. Involvement of RNA helicases p68 and p72 in colon cancer. Cancer Res. 2007;67:7572-8 pubmed
    The homologous proteins p68 and p72 are members of the DEAD box family of RNA helicases...