DDC

Summary

Gene Symbol: DDC
Description: dopa decarboxylase
Alias: AADC, aromatic-L-amino-acid decarboxylase, dopa decarboxylase (aromatic L-amino acid decarboxylase)
Species: human
Products:     DDC

Top Publications

  1. Ribases M, Ramos Quiroga J, Hervas A, Bosch R, Bielsa A, Gastaminza X, et al. Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB. Mol Psychiatry. 2009;14:71-85 pubmed
    ..Several significant associations were found after correcting for multiple testing: (1) the DDC gene was strongly associated with both adulthood (P=0.00053; odds ratio (OR)=2.17) and childhood ADHD (P=0...
  2. Ichinose H, Kurosawa Y, Titani K, Fujita K, Nagatsu T. Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase. Biochem Biophys Res Commun. 1989;164:1024-30 pubmed
    ..9 kDa. The amino acid sequence Asn-Phe-Asn-Pro-His-Lys-Trp around a possible cofactor (pyridoxal phosphate) binding site is identical in human, Drosophila, and pig enzymes. ..
  3. Wafa L, Cheng H, Rao M, Nelson C, Cox M, Hirst M, et al. Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system. Biochem J. 2003;375:373-83 pubmed
    ..b>DDC (L-dopa decarboxylase) was detected multiple times as a novel AR-interacting protein, which was subsequently ..
  4. Bozzi F, Luksch R, Collini P, Gambirasio F, Barzanò E, Polastri D, et al. Molecular detection of dopamine decarboxylase expression by means of reverse transcriptase and polymerase chain reaction in bone marrow and peripheral blood: utility as a tumor marker for neuroblastoma. Diagn Mol Pathol. 2004;13:135-43 pubmed
    A highly sensitive molecular method was used to evaluate the presence of dopamine decarboxylase (DDC) mRNA in the bone marrow and peripheral blood of patients with neuroblastoma (NB)...
  5. Vassilacopoulou D, Sideris D, Vassiliou A, Fragoulis E. Identification and characterization of a novel form of the human L-dopa decarboxylase mRNA. Neurochem Res. 2004;29:1817-23 pubmed
    L-Dopa decarboxylase (DDC) has been cloned from several species and was shown to undergo alternative splicing within its 5'-untranslated and coding regions...
  6. Zhang H, Ye Y, Wang X, Gelernter J, Ma J, Li M. DOPA decarboxylase gene is associated with nicotine dependence. Pharmacogenomics. 2006;7:1159-66 pubmed
    ..powerful method, we re-analyzed an existing dataset, which confirmed the association of the DOPA decarboxylase (DDC) gene on chromosome 7p11 with measures of nicotine dependence...
  7. Avgeris M, Koutalellis G, Fragoulis E, Scorilas A. Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer. Clin Biochem. 2008;41:1140-9 pubmed publisher
    L-Dopa decarboxylase (DDC) is a pyridoxal 5'-phosphate-dependent enzyme that was found to be involved in many malignancies...
  8. Treviño L, Yang W, French D, Hunger S, Carroll W, Devidas M, et al. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet. 2009;41:1001-5 pubmed publisher
    ..86, respectively) and were associated with methotrexate accumulation and gene expression pattern in leukemic lymphoblasts. We conclude that germline variants affect susceptibility to, and characteristics of, specific ALL subtypes. ..
  9. Kokkinou I, Fragoulis E, Vassilacopoulou D. The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase. J Neuroimmunol. 2009;216:51-8 pubmed publisher
    In the present study we demonstrate that enzymatically active l-Dopa decarboxylase (DDC) is expressed in U937 cells, an important model of human macrophage function. The mRNA coding for the enzyme was found to be of the neural-type...

More Information

Publications112 found, 100 shown here

  1. Kontos C, Papadopoulos I, Fragoulis E, Scorilas A. Quantitative expression analysis and prognostic significance of L-DOPA decarboxylase in colorectal adenocarcinoma. Br J Cancer. 2010;102:1384-90 pubmed publisher
    L-DOPA decarboxylase (DDC) is an enzyme that catalyses, mainly, the decarboxylation of L-DOPA to dopamine and was found to be involved in many malignancies...
  2. Chalatsa I, Fragoulis E, Vassilacopoulou D. Release of membrane-associated L-dopa decarboxylase from human cells. Neurochem Res. 2011;36:1426-34 pubmed publisher
    ..neural and non-neural origin, by temperature-induced phase separation in Triton X-114 resulted in the detection of DDC molecules in all separation phases...
  3. Koutalellis G, Stravodimos K, Avgeris M, Mavridis K, Scorilas A, Lazaris A, et al. L-dopa decarboxylase (DDC) gene expression is related to outcome in patients with prostate cancer. BJU Int. 2012;110:E267-73 pubmed publisher
    What's known on the subject? and What does the study add? L-dopa decarboxylase (DDC) has been documented as a novel co-activator of androgen receptor transcriptional activity...
  4. Montioli R, Oppici E, Cellini B, Roncador A, Dindo M, Voltattorni C. S250F variant associated with aromatic amino acid decarboxylase deficiency: molecular defects and intracellular rescue by pyridoxine. Hum Mol Genet. 2013;22:1615-24 pubmed publisher
    Dopa or aromatic amino acid decarboxylase (DDC, AADC) is a pyridoxal 5'-phosphate-dependent enzyme that catalyses the production of the neurotransmitters dopamine and serotonin...
  5. Sumi Ichinose C, Ichinose H, Takahashi E, Hori T, Nagatsu T. Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis. Biochemistry. 1992;31:2229-38 pubmed
    Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones ..
  6. Siaterli M, Vassilacopoulou D, Fragoulis E. Cloning and expression of human placental L-Dopa decarboxylase. Neurochem Res. 2003;28:797-803 pubmed
    L-Dopa decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-Dopa to dopamine...
  7. Kokkinou I, Nikolouzou E, Hatzimanolis A, Fragoulis E, Vassilacopoulou D. Expression of enzymatically active L-DOPA decarboxylase in human peripheral leukocytes. Blood Cells Mol Dis. 2009;42:92-8 pubmed publisher
    L-DOPA decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-DOPA to dopamine...
  8. Montioli R, Cellini B, Borri Voltattorni C. Molecular insights into the pathogenicity of variants associated with the aromatic amino acid decarboxylase deficiency. J Inherit Metab Dis. 2011;34:1213-24 pubmed publisher
    Dopa decarboxylase (DDC or AADC) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the decarboxylation of L-aromatic amino acids into the corresponding aromatic amines...
  9. Giardina G, Montioli R, Gianni S, Cellini B, Paiardini A, Voltattorni C, et al. Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases. Proc Natl Acad Sci U S A. 2011;108:20514-9 pubmed publisher
  10. Christie A, Stanhope M, Gandler H, Lameyer T, Pascual M, Shea D, et al. Molecular characterization of putative neuropeptide, amine, diffusible gas and small molecule transmitter biosynthetic enzymes in the eyestalk ganglia of the American lobster, Homarus americanus. Invert Neurosci. 2018;18:12 pubmed publisher
    ..responsible for dopamine [tryptophan-phenylalanine hydroxylase (TPH), tyrosine hydroxylase and DOPA decarboxylase (DDC)], octopamine (TPH, tyrosine decarboxylase and tyramine β-hydroxylase), serotonin (TPH or tryptophan hydroxylase ..
  11. MUFSON E, He B, Ginsberg S, Carper B, Bieler G, Crawford F, et al. Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study. J Neurotrauma. 2018;: pubmed publisher
    ..subunit beta-2 gene (Chrnb2), monoaminergic enzymes catechol-O-methyltransferase (Comt) and dopa decarboxylase (Ddc), chloride channels Clcn4 and Clcn5, scaffolding protein caveolin 1 (Cav1), cortical development/cytoskeleton ..
  12. Kalb D, Gressler J, Hoffmeister D. Active-Site Engineering Expands the Substrate Profile of the Basidiomycete L-Tryptophan Decarboxylase CsTDC. Chembiochem. 2016;17:132-6 pubmed publisher
    ..Here, we report on the in vitro characterization of heterologously produced Ceriporiopsis subvermispora AADC, now referred to as CsTDC, which is the first characterized basidiomycete AADC...
  13. Sterkel M, Ons S, Oliveira P. DOPA decarboxylase is essential for cuticle tanning in Rhodnius prolixus (Hemiptera: Reduviidae), affecting ecdysis, survival and reproduction. Insect Biochem Mol Biol. 2019;108:24-31 pubmed publisher
    ..In adult females, the knockdown of AADC-2 resulted in a reduction in the hatching of eggs; the nymphs that managed to hatch failed to tan the cuticle and ..
  14. Delp M, Cline M, Gilbert E. The central effects of alpha-melanocyte stimulating hormone (?-MSH) in chicks involve changes in gene expression of neuropeptide Y and other factors in distinct hypothalamic nuclei. Neurosci Lett. 2017;651:52-56 pubmed publisher
    ..NPY, c-Fos, and DOPA decarboxylase (DDC) mRNAs were greater in treated than vehicle-injected chicks in the DMN...
  15. Huang L, Deng M, Zhang S, Lu S, Gui X, Fang Y. ?-asarone and levodopa coadministration increases striatal levels of dopamine and levodopa and improves behavioral competence in Parkinson's rat by enhancing dopa decarboxylase activity. Biomed Pharmacother. 2017;94:666-678 pubmed publisher
    ..The behavioral tests were assessed. Neurotransmitters, dopa decarboxylase (DDC), tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), monoamine oxidase B (MAO-B) and dopamine ..
  16. Dkhil M, Al Quraishy S, Abdel Baki A, Ghanjati F, Arauzo Bravo M, Delic D, et al. Epigenetic modifications of gene promoter DNA in the liver of adult female mice masculinized by testosterone. J Steroid Biochem Mol Biol. 2015;145:121-30 pubmed publisher
    ..However, T decreases DNA-methylation of the Cor-promoter region of Ddc encoding the AR-coactivator dopa decarboxylase...
  17. Das A, Verma A, Mukherjee K. Synthesis of dopamine in E. coli using plasmid-based expression system and its marked effect on host growth profiles. Prep Biochem Biotechnol. 2017;47:754-760 pubmed publisher
    ..coli and an engineered dopa decarboxylase (DDC) from pig kidney cell...
  18. Montioli R, Voltattorni C, Bertoldi M. Parkinson's Disease: Recent Updates in the Identification of Human Dopa Decarboxylase Inhibitors. Curr Drug Metab. 2016;17:513-8 pubmed
    ..of benserazide, are substrate analogues both endowed with a hydrazine function, which irreversibly bind not only to DDC but also to free pyridoxal 5'-phosphate and pyridoxal 5'-phosphate-dependent enzymes...
  19. Blohberger J, Buck T, Berg D, Berg U, Kunz L, Mayerhofer A. L-DOPA in the hu man ovarian follicular fluid acts as an antioxidant factor on granulosa cells. J Ovarian Res. 2016;9:62 pubmed
    ..ROS-scavenging functions, we studied whether it exerts such actions in human GCs and whether DOPA-decarboxylase (DDC), the enzyme converting L-DOPA to DA, is expressed in the human ovary...
  20. Ito K, Yoshikawa M, Fujii T, Tabunoki H, Yokoyama T. Melanin pigmentation gives rise to black spots on the wings of the silkworm Bombyx mori. J Insect Physiol. 2016;91-92:100-6 pubmed publisher
    ..found that the expression levels of yellow and laccase2 were increased just before pigmentation, whereas those of DDC, tan, and TH were increased when the apex of the wing turned black...
  21. Orenlili Yaylagul E, Cansev M, Celikler Kasimogullari S. In vivo protective effect of Uridine, a pyrimidine nucleoside, on genotoxicity induced by Levodopa/Carbidopa in mice. Food Chem Toxicol. 2015;82:36-41 pubmed publisher
    ..These findings might enhance our understanding for the complications of a common Parkinson's treatment and confer benefit in terms of reducing a possible genotoxic effect of this treatment. ..
  22. Adamska I, Marhelava K, Walkiewicz D, Kedzierska U, Markowska M, Majewski P. All genes encoding enzymes participating in melatonin biosynthesis in the chicken pineal gland are transcribed rhythmically. J Physiol Pharmacol. 2016;67:521-530 pubmed
    ..Additionally, in the pineal gland of maturing chickens, the dopa decarboxylase (Ddc) gene is transcribed rhythmically at a specific stage of the developmental process...
  23. Kow R, Sikkema C, Wheeler J, Wilkinson C, Kraemer B. DOPA Decarboxylase Modulates Tau Toxicity. Biol Psychiatry. 2018;83:438-446 pubmed publisher
    ..We identified one dopamine synthesis gene, DOPA decarboxylase (DDC), as a suppressor of tau toxicity in tau transgenic worms. Loss of the C...
  24. M Angale P, Staveley B. Knockdown of the putative Lifeguard homologue CG3814 in neurons of Drosophila melanogaster. Genet Mol Res. 2016;15: pubmed publisher
    ..homologue of Lifeguard, and knocked down CG3814/LFG expression under the control of the Dopa decarboxylase (Ddc-Gal4) transgene in Drosophila melanogaster neurons to investigate whether it possesses neuroprotective activity...
  25. Liu Q, Xu T, Zhang Z, Leung C, You D, Wang S, et al. Effects of co-administration of ketamine and ethanol on the dopamine system via the cortex-striatum circuitry. Life Sci. 2017;179:1-8 pubmed publisher
    ..of the combined drug treatment on the transcriptional output of tyrosine hydroxylase (TH), dopa decarboxylase (DDC), synaptosomal-associated protein 25 (SNAP25), and vesicular monoamine transporter 2 (VMAT2) as well as protein ..
  26. Carter D. Molecular phenotyping of transient postnatal tyrosine hydroxylase neurons in the rat bed nucleus of the stria terminalis. J Chem Neuroanat. 2017;82:29-38 pubmed publisher
    ..have a partial catecholaminergic phenotype (tyrosine hydroxylase-positive/dopa decarboxylase-negative; TH+ve/DDC-ve) that is lost at PN40...
  27. Andersen O, Aaseth J. A review of pitfalls and progress in chelation treatment of metal poisonings. J Trace Elem Med Biol. 2016;38:74-80 pubmed publisher
    ..Also, diethyl dithiocarbamate (DDC) has been used as antidote in acute experimental animal parenteral Cd poisoning, and both DDC and tetraethylthiuram ..
  28. Hirose A, Ochiai W, Yamamoto Y, Fukaya M, Iwasaki H, Wakui N, et al. Analysis of CYP2R1 and CYP26A1 Expression Patterns in Regeneration in Mice with Liver Injury. Biol Pharm Bull. 2016;39:1955-1960 pubmed
    ..Liver injury was induced by 4-week repeated doses of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in the diet...
  29. Marachelian A, Villablanca J, Liu C, Liu B, Goodarzian F, Lai H, et al. Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis. Clin Cancer Res. 2017;23:5374-5383 pubmed publisher
    ..b>Experimental Design: mRNA for CHGA, DCX, DDC, PHOX2B, and TH was quantified in bone marrow and blood from 101 patients concurrently with clinical disease ..
  30. Neelakantan P, Khan K, Hei Ng G, Yip C, Zhang C, Pan Cheung G. Does the Orifice-directed Dentin Conservation Access Design Debride Pulp Chamber and Mesial Root Canal Systems of Mandibular Molars Similar to a Traditional Access Design?. J Endod. 2018;44:274-279 pubmed publisher
    ..This study examined if 1 type of CEC (orifice-directed dentin conservation [DDC] access) was able to debride the pulp chamber, root canals, and isthmus of mesial roots of mandibular molars ..
  31. Wassenberg T, Willemsen M, Geurtz P, Lammens M, Verrijp K, Wilmer M, et al. Urinary dopamine in aromatic L-amino acid decarboxylase deficiency: the unsolved paradox. Mol Genet Metab. 2010;101:349-56 pubmed publisher
    In aromatic L-amino acid decarboxylase (AADC) deficiency, a neurotransmitter biosynthesis defect, paradoxical normal or increased levels of urinary dopamine have been reported...
  32. Frederiksen M, Vorkamp K, Jensen N, Sørensen J, Knudsen L, Sørensen L, et al. Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model. Chemosphere. 2016;162:308-14 pubmed publisher
    ..The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, ?, ? and ?-HBCDD as well as syn- and anti-DDC-CO...
  33. Ballanger B, Beaudoin Gobert M, Neumane S, Epinat J, Météreau E, Duperrier S, et al. Imaging Dopamine and Serotonin Systems on MPTP Monkeys: A Longitudinal PET Investigation of Compensatory Mechanisms. J Neurosci. 2016;36:1577-89 pubmed publisher
    ..For example, our findings suggest that the external pallidum could be a new target for cell-based therapies to reduce PD symptoms. ..
  34. Schwinge D, von Haxthausen F, Quaas A, Carambia A, Otto B, Glaser F, et al. Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related to IL-12 signaling. J Hepatol. 2017;66:798-805 pubmed publisher
    ..Treg were expanded by repeated injection of IL-2/IL-2Ab complex in mouse models of cholangitis (Mdr2-/-, DDC) or colitis (dextran sulfate sodium [DSS]) as control...
  35. Chen L, Luo M, Sun X, Qin J, Yu C, Wen Y, et al. DJ-1 deficiency attenuates expansion of liver progenitor cells through modulating the inflammatory and fibrogenic niches. Cell Death Dis. 2016;7:e2257 pubmed publisher
    ..formation of LPC-associated fibrosis and inflammation was examined in a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet-induced liver injury murine model...
  36. Ghosh P, Sarkar K, Bhaduri N, Ray A, Sarkar K, Sinha S, et al. Catecholaminergic gene variants: contribution in ADHD and associated comorbid attributes in the eastern Indian probands. Biomed Res Int. 2013;2013:918410 pubmed publisher
    ..We have assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (rs1800496, rs1801028, and rs1799732), DRD4 (rs4646984 and rs4646983), and COMT (..
  37. Tang Z, Liu L, Li Y, Dong J, Li M, Huang J, et al. Urinary Metabolomics Reveals Alterations of Aromatic Amino Acid Metabolism of Alzheimer's Disease in the Transgenic CRND8 Mice. Curr Alzheimer Res. 2016;13:764-76 pubmed
    ..The perturbations of metabolic pathways may have far-reaching implications for early diagnosis and intervention in AD. ..
  38. Masaki Y, Izumi Y, Matsumura A, Akaike A, Kume T. Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model. Eur J Pharmacol. 2017;798:26-34 pubmed publisher
    ..Previously, we have isolated 2',3'-dihydroxy-4',6'-dimethoxychalcone (DDC) from green perilla leaves as an activator of the Nrf2-ARE pathway...
  39. Capilla A, Karachentsev D, Patterson R, Hermann A, Juarez M, McGinnis W. Toll pathway is required for wound-induced expression of barrier repair genes in the Drosophila epidermis. Proc Natl Acad Sci U S A. 2017;114:E2682-E2688 pubmed publisher
    ..Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple)...
  40. Fakhoury M, Rompré P, Boye S. Role of the dorsal diencephalic conduction system in the brain reward circuitry. Behav Brain Res. 2016;296:431-441 pubmed publisher
    ..studies suggests that electrolytic lesion of the habenula, which lies in the dorsal diencephalic conduction system (DDC), degrades the intracranial self-stimulation (ICSS)...
  41. Nikishin D, Alyoshina N, Shmukler Y. Synthesis and Membrane Transport of Serotonin in the Developing Ovarian Follicle of Mouse. Dokl Biochem Biophys. 2018;478:4-7 pubmed publisher
    ..cells and Tph2 mRNA in oocytes isolated from primary multilayer ovarian follicles of mouse and the absence of Ddc expression, which indicates that serotonin cannot be synthesized in a developing ovarian follicle...
  42. Papadopoulos E, Fragoulis E, Scorilas A. Human L-DOPA decarboxylase mRNA is a target of miR-145: A prediction to validation workflow. Gene. 2015;554:174-80 pubmed publisher
    l-DOPA decarboxylase (DDC) is a multiply-regulated gene which encodes the enzyme that catalyzes the biosynthesis of dopamine in humans...
  43. Mobascher A, Bohus M, Dahmen N, Dietl L, Giegling I, Jungkunz M, et al. Association between dopa decarboxylase gene variants and borderline personality disorder. Psychiatry Res. 2014;219:693-5 pubmed publisher
    ..The present collaborative candidate gene study of 987 BPD cases and 1110 healthy controls found an association between BPD and single nucleotide polymorphism rs12718541 in the dopa decarboxylase gene. ..
  44. Su G, Letcher R, Moore J, Williams L, Martin P, de Solla S, et al. Spatial and temporal comparisons of legacy and emerging flame retardants in herring gull eggs from colonies spanning the Laurentian Great Lakes of Canada and United States. Environ Res. 2015;142:720-30 pubmed publisher
    ..g., exposure-effect implications and metabolism of FRs, i.e. OPE-FRs, and emphasizes the importance of continued monitoring of CEC-FRs whose concentrations appear to be increasing, including BDE-209, HBCDD and DDC-COs.
  45. Abu Serie M. Evaluation of the selective toxic effect of the charge switchable diethyldithiocarbamate-loaded nanoparticles between hepatic normal and cancerous cells. Sci Rep. 2018;8:4617 pubmed publisher
    ..Both NPs were loaded with diethyldithiocarbamate (DDC) which is an inhibitor of the critical enzyme, aldehyde dehydrogenase (ALDH) 1A1, for CSCs survival...
  46. Yu Y, Panhuysen C, Kranzler H, Hesselbrock V, Rounsaville B, Weiss R, et al. Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans. Hum Mol Genet. 2006;15:2192-9 pubmed
    We report here a study considering association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence (ND) or a quantitative measure for ND using the Fagerstrom Test for Nicotine ..
  47. Petropoulos M, Karamolegkou G, Rosmaraki E, Tsakas S. Hydrogen peroxide signals E. coli phagocytosis by human polymorphonuclear cells; up-stream and down-stream pathway. Redox Biol. 2015;6:100-105 pubmed publisher
    ..of H2O2 synthesis by specific inhibitors, N-ethylmaleimide (ΝΕΜ) for NADPH oxidase and diethyldithiocarbamate (DDC) for superoxide dismutase (SOD), decreased E. coli phagocytosis, as well...
  48. Derringer J, Krueger R, Dick D, Saccone S, Grucza R, Agrawal A, et al. Predicting sensation seeking from dopamine genes. A candidate-system approach. Psychol Sci. 2010;21:1282-90 pubmed publisher
  49. Fiorotto R, Raizner A, Morell C, Torsello B, Scirpo R, Fabris L, et al. Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. J Hepatol. 2013;59:124-30 pubmed publisher
    ..Treatment with DDC (3,5-diethoxycarbonyl-1,4-dihydrocollidine) or ANIT (alpha-naphthyl-isothiocyanate) was used to induce biliary ..
  50. Papadopoulos E, Petraki C, Gregorakis A, Chra E, Fragoulis E, Scorilas A. L-DOPA decarboxylase mRNA levels provide high diagnostic accuracy and discrimination between clear cell and non-clear cell subtypes in renal cell carcinoma. Clin Biochem. 2015;48:590-5 pubmed publisher
    ..L-DOPA decarboxylase (DDC) is the gene encoding the enzyme that catalyzes the biosynthesis of dopamine in humans...
  51. Liang J, Han Q, Ding H, Li J. Biochemical identification of residues that discriminate between 3,4-dihydroxyphenylalanine decarboxylase and 3,4-dihydroxyphenylacetaldehyde synthase-mediated reactions. Insect Biochem Mol Biol. 2017;91:34-43 pubmed publisher
    In available insect genomes, there are several L-3,4-dihydroxyphenylalanine (L-dopa) decarboxylase (DDC)-like or aromatic amino acid decarboxylase (AAAD) sequences. This contrasts to those of mammals whose genomes contain only one DDC...
  52. Bennett C, Van Rijn E, Jung S, Inaba K, Steinman R, Kapsenberg M, et al. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol. 2005;169:569-76 pubmed
    ..in vivo functions in skin immunity and tolerance could not be determined, in particular in relation to dermal DC (dDC)...
  53. Anderson B, Schnetz Boutaud N, Bartlett J, Wotawa A, Wright H, Abramson R, et al. Examination of association of genes in the serotonin system to autism. Neurogenetics. 2009;10:209-16 pubmed publisher
    ..These data suggest that variation within genes on the serotonin pathway, particularly HTR3A, may have modest effects on autism risk. ..
  54. Takagi H, Seta Y, Kataoka S, Nakatomi M, Toyono T, Kawamoto T. Mash1-expressing cells could differentiate to type III cells in adult mouse taste buds. Anat Sci Int. 2018;93:422-429 pubmed publisher
    ..We found that the cells expressing type III cell markers-aromatic L-amino acid decarboxylase (AADC), carbonic anhydrase 4 (CA4), glutamate decarboxylase 67 (GAD67), neural cell adhesion molecule (NCAM), and ..
  55. Bian Z, Miao Q, Zhong W, Zhang H, Wang Q, Peng Y, et al. Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease. J Autoimmun. 2015;63:76-87 pubmed publisher
    ..first, common bile duct ligation (CBDL) and second, feeding of 3, 5-diethoxy-carbonyl-1, 4-dihydrocollidine (DDC)...
  56. Li X, Yu J, Li J, Wu Y, Li B. Dopaminergic Dysfunction in Mammalian Dopamine Neurons Induced by Simazine Neurotoxicity. Int J Mol Sci. 2017;18: pubmed publisher
    ..western blotting were performed to analyze the mRNA and protein expression of aromatic amino acid decarboxylase (AADC), tyrosine hydroxylase (DYT5b), dopamine transporter (DAT), monoamine vesicular transporter 2 (VMAT2), monoamine ..
  57. Chen Y, Guldiken N, Spurny M, Mohammed H, Haybaeck J, Pollheimer M, et al. Loss of keratin 19 favours the development of cholestatic liver disease through decreased ductular reaction. J Pathol. 2015;237:343-54 pubmed publisher
    ..K19 wild-type (WT) and knockout (KO) mice were fed: (a) 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC); (b) cholic acid (CA); (c) a choline-deficient, ethionine-supplemented (CDE) diet; or (d) were subjected to common ..
  58. Cubells J, Schroeder J, Barrie E, Manvich D, Sadee W, Berg T, et al. Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice. PLoS ONE. 2016;11:e0154864 pubmed publisher
    ..treated with L-3,4-dihydroxyphenylserine (DOPS), which can be converted to NE by aromatic acid decarboxylase (AADC) in the absence of DBH...
  59. Gálvez Cancino F, Roco J, Rojas Colonelli N, Flores C, Murgas P, Cruz Gómez S, et al. A short hairpin RNA-based adjuvant targeting NF-κB repressor IκBα promotes migration of dermal dendritic cells to draining lymph nodes and antitumor CTL responses induced by DNA vaccination. Vaccine. 2017;35:4148-4154 pubmed publisher
    ..the migration of skin migratory dendritic cells to draining lymph nodes and maturation of dermal dendritic cells (dDC)...
  60. Scherer L, McPherson J, Wasmuth J, Marsh J. Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs. Genomics. 1992;13:469-71 pubmed
    We have cloned full-length DDC cDNAs from a human hepatoma cDNA library [DDC; dopa decarboxylase; aromatic-L-amino acid decarboxylase, EC 4.1.1.28]...
  61. Le Van Thai A, Coste E, Allen J, Palmiter R, Weber M. Identification of a neuron-specific promoter of human aromatic L-amino acid decarboxylase gene. Brain Res Mol Brain Res. 1993;17:227-38 pubmed
    We have cloned the 5' region of human aromatic L-amino acid decarboxylase (AADC) gene in a cosmid and an overlapping lambda clone, and sequenced the first five exons...
  62. Tay S, Poh K, Hyland K, Pang Y, Ong H, Low P, et al. Unusually mild phenotype of AADC deficiency in 2 siblings. Mol Genet Metab. 2007;91:374-8 pubmed
    ..Analysis of CSF biogenic amines, plasma AADC levels and direct sequencing of the DDC gene was performed...
  63. Corominas R, Sobrido M, Ribases M, Cuenca León E, Blanco Arias P, Narberhaus B, et al. Association study of the serotoninergic system in migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:177-84 pubmed publisher
    ..and MAOA (rs3027400G-rs2072743C) genes conferring susceptibility to MO, and a four-marker haplotype in DDC was specific of MA (rs2329340A-rs11974297C-rs2044859T-rs11761683G)...
  64. Kristjansson S, Agrawal A, Lessov Schlaggar C, Madden P, Cooper M, Bucholz K, et al. The relationship between rs3779084 in the dopa decarboxylase (DDC) gene and alcohol consumption is mediated by drinking motives in regular smokers. Alcohol Clin Exp Res. 2012;36:162-70 pubmed publisher
    ..2 single-nucleotide polymorphisms (SNPs) from genes involved in serotonin (TPH2; rs1386496) and dopamine synthesis (DDC; rs3779084)...
  65. Chien Y, Chen P, Lee N, Hsieh W, Chiu P, Hwu W, et al. 3-O-methyldopa levels in newborns: Result of newborn screening for aromatic l-amino-acid decarboxylase deficiency. Mol Genet Metab. 2016;118:259-63 pubmed publisher
    The diagnosis of aromatic l-amino-acid decarboxylase (AADC) deficiency is often delayed because a cerebrospinal fluid analysis is required to detect a neurotransmitter deficiency...
  66. Purves Tyson T, Owens S, Rothmond D, Halliday G, Double K, Stevens J, et al. Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain. Transl Psychiatry. 2017;7:e1003 pubmed publisher
    ..TH and aromatic acid decarboxylase (AADC) mRNA and TH protein were unchanged in the midbrain in schizophrenia compared with controls...
  67. Bonsall D, Kokkinou M, Veronese M, Coello C, Wells L, Howes O. Single cocaine exposure does not alter striatal pre-synaptic dopamine function in mice: an [18 F]-FDOPA PET study. J Neurochem. 2017;143:551-560 pubmed publisher
  68. Feldbrügge L, Jiang Z, Csizmadia E, Mitsuhashi S, Tran S, Yee E, et al. Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis. Purinergic Signal. 2018;14:37-46 pubmed publisher
    ..time points after exposure to carbon tetrachloride (CCl4) or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) or partial hepatectomy in C57BL/6 wild-type and globally NTPDase2-deficient (Entpd2 null) mice...
  69. Duan C, Su Y, Zhao C, Lu L, Xu Q, Yang H. The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD. Brain Res Brain Res Protoc. 2005;16:37-43 pubmed
    ..Now, we have developed a simple, fast, and reliable method to assay the activities of TH and AADC and have provided the possibility of ex vivo gene therapy for PD by genetically modifying cells with separate hTH, ..
  70. Menheniott T, Woodfine K, Schulz R, Wood A, Monk D, Giraud A, et al. Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10. Mol Cell Biol. 2008;28:386-96 pubmed
    ..screen with mouse uniparental duplications, we have identified a novel imprinted gene, Dopa decarboxylase (Ddc), on chromosome 11...
  71. Geomela P, Kontos C, Yiotakis I, Fragoulis E, Scorilas A. L-DOPA decarboxylase mRNA expression is associated with tumor stage and size in head and neck squamous cell carcinoma: a retrospective cohort study. BMC Cancer. 2012;12:484 pubmed publisher
    ..The DDC gene encodes L-DOPA decarboxylase, an enzyme catalyzing the decarboxylation of L-DOPA to dopamine...
  72. Baldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, et al. Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron. 2014;81:77-90 pubmed publisher
    ..These data confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology. ..
  73. Yu H, Liu J, Yang A, Yang G, Yang W, Lei H, et al. Lack of Association Between Polymorphisms in Dopa Decarboxylase and Dopamine Receptor-1 Genes With Childhood Autism in Chinese Han Population. J Child Neurol. 2016;31:560-4 pubmed publisher
    ..This study is to determine the association of single-nucleotide polymorphisms in dopa decarboxylase (DDC) and dopamine receptor-1 (DRD1) genes with childhood autism, in a Chinese Han population...
  74. Sanna M, Ghelardini C, Galeotti N. Blockade of the spinal BDNF-activated JNK pathway prevents the development of antiretroviral-induced neuropathic pain. Neuropharmacology. 2016;105:543-552 pubmed publisher
    ..Mice were exposed to zalcitabine (2',3'-dideoxycytidine, ddC) and stavudine (2',3'-didehydro-3'-deoxythymidine, d4T) that induced a persistent mechanical allodynia and a ..
  75. Kozina E, Kim A, Kurina A, Ugrumov M. Cooperative synthesis of dopamine by non-dopaminergic neurons as a compensatory mechanism in the striatum of mice with MPTP-induced Parkinsonism. Neurobiol Dis. 2017;98:108-121 pubmed publisher
    ..one of the enzymes of dopamine (DA) synthesis, tyrosine hydroxylase (TH) or aromatic l-amino acid decarboxylase (AADC)...
  76. Yang J, Yang J, Wang L, Moore A, Liang S, Ran C. Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and 64CuCl2. Sci Rep. 2017;7:8298 pubmed publisher
    ..an inactive 64Cu ligand, was first injected to allow it to metabolize into diethyldithiocarbamate (DDC), a strong 64Cu ligand, which can chelate 64CuCl2 from the following injection to ..
  77. Pappan K, Kennedy A, Magoulas P, Hanchard N, Sun Q, Elsea S. Clinical Metabolomics to Segregate Aromatic Amino Acid Decarboxylase Deficiency From Drug-Induced Metabolite Elevations. Pediatr Neurol. 2017;75:66-72 pubmed publisher
    ..We investigated the analyte changes associated with aromatic amino acid decarboxylase (AADC) deficiency and dopamine medication treatment...
  78. Yi Z, Xie L, Zhou C, Yuan H, Ouyang S, Fang Z, et al. P2Y12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2',3'-dideoxycytidine. Purinergic Signal. 2018;14:47-58 pubmed publisher
    ..of the P2Y12 receptor in neuropathic pain induced by HIV envelope glycoprotein 120 (gp120) combined with ddC (2',3'-dideoxycytidine). A rat model of gp120+ddC-induced neuropathic pain was used...
  79. Granados A, Del Olmo L Oacute Pez A, Peccati F, Billard T, Sodupe M, Vallribera A. Fluorous L-Carbidopa Precursors: Highly Enantioselective Synthesis and Computational Prediction of Bioactivity. J Org Chem. 2017;: pubmed publisher
    ..compounds are precursors of fluorinated analogues of L-Carbidopa, which is known to inhibit DOPA decarboxylase (DDC), a key protein in Parkinson's disease...
  80. Pengfei Z, jianhua Z, Rongmin Y, Jiachen Z. Enzyme Inhibitors Cause Multiple Effects on Accumulation of Monoterpene Indole Alkaloids in Catharanthus Roseus Cambial Meristematic Cell Cultures. Pharmacogn Mag. 2017;13:732-737 pubmed publisher
    ..roseus dedifferentiated cell (DDC) culture...
  81. Lauritsen M, Børglum A, Betancur C, Philippe A, Kruse T, Leboyer M, et al. Investigation of two variants in the DOPA decarboxylase gene in patients with autism. Am J Med Genet. 2002;114:466-70 pubmed
    ..DOPA decarboxylase (DDC) is involved in both the catecholaminergic and serotonergic pathways and may be considered a functional candidate ..
  82. Børglum A, Kirov G, Craddock N, Mors O, Muir W, Murray V, et al. Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet. 2003;117B:18-22 pubmed
    Dopa decarboxylase (DDC) catalyses the synthesis of both dopamine and serotonin as well as trace amines suggested to possess neuromodulating capabilities...
  83. Lee H, Tsai C, Chi C, Chang T, Lee H. Aromatic L-amino acid decarboxylase deficiency in Taiwan. Eur J Paediatr Neurol. 2009;13:135-40 pubmed publisher
    Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive disorder of neurotransmitter synthesis. It has unique clinical presentations...
  84. Kitahama K, Ikemoto K, Jouvet A, Araneda S, Nagatsu I, Raynaud B, et al. Aromatic L-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medulla. J Chem Neuroanat. 2009;38:130-40 pubmed publisher
    ..with precision the localization of neurons and fibers immunoreactive (ir) for aromatic L-amino acid decarboxylase (AADC), the second-step enzyme responsible for conversion of L-dihydroxyphenylalanine (L-DOPA) to dopamine (DA) and 5-..
  85. Meda S, Jagannathan K, Gelernter J, Calhoun V, Liu J, Stevens M, et al. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. Neuroimage. 2010;53:1007-15 pubmed publisher
  86. Costas J, Gratacos M, Escaramis G, Martin Santos R, de Diego Y, Baca Garcia E, et al. Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women. J Psychiatr Res. 2010;44:717-24 pubmed publisher
    ..Two intronic SNPs, one at the serotonin transporter gene (SLC6A4) and another at dopa decarboxylase (DDC), were significantly associated to STAI anxiety scores after multiple testing correction (nominal P=0.0000513 and 0...
  87. Graziano C, Wischmeijer A, Pippucci T, Fusco C, Diquigiovanni C, Nõukas M, et al. Syndromic intellectual disability: a new phenotype caused by an aromatic amino acid decarboxylase gene (DDC) variant. Gene. 2015;559:144-8 pubmed publisher
    ..Mutations in DDC cause a recessive metabolic disorder (aromatic amino acid decarboxylase, AADC, deficiency, OMIM #608643) characterized by hypotonia, oculogyric crises, excessive sweating, temperature ..
  88. Das K, Martinez S, Arnold E. Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..and F116Y, were detected in patients failing therapies with dideoxynucleosides (didanosine [ddI], zalcitabine [ddC]) and/or zidovudine (AZT)...
  89. Niu J, Xiong J, Hu D, Zeng F, Nie S, Mao S, et al. 2',3'-Dideoxycytidine Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease. Neurochem Res. 2017;42:2996-3004 pubmed publisher
    ..of this study was to investigate the neuroprotective effects of a DNA polymerase-? inhibitor 2',3'-dideoxycytidine (DDC) in PD models...
  90. Prestes J, Nascimento D, Neto I, Tibana R, Shiguemoto G, Perez S, et al. The Effects of Muscle Strength Responsiveness to Periodized Resistance Training on Resistin, Leptin, and Cytokine in Elderly Postmenopausal Women. J Strength Cond Res. 2018;32:113-120 pubmed publisher
    Prestes, J, Nascimento, DdC, Neto, IVS, Tibana, RA, Shiguemoto, GE, Perez, SEA, Botero, JP, Schoenfeld, BJ, and Pereira, GB...
  91. Gergs U, Jung F, Buchwalow I, Hofmann B, Simm A, Treede H, et al. Pharmacological and physiological assessment of serotonin formation and degradation in isolated preparations from mouse and human heart. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00350.2017 pubmed publisher
    ..Conceivably, this formation of 5-HT and possibly impaired degradation may be clinically relevant in cases of unexplained tachycardia and other arrhythmias. ..
  92. Caine C, Shohat M, Kim J, Nakanishi K, Homma S, Mosharov E, et al. A pathogenic S250F missense mutation results in a mouse model of mild aromatic l-amino acid decarboxylase (AADC) deficiency. Hum Mol Genet. 2017;26:4406-4415 pubmed publisher
    Homozygous mutations in the aromatic l-amino acid decarboxylase (AADC) gene result in a severe depletion of its namesake protein, triggering a debilitating and often fatal form of infantile Parkinsonism known as AADC deficiency...