Gene Symbol: DCTN4
Description: dynactin subunit 4
Alias: DYN4, P62, dynactin subunit 4, dynactin 4 (p62), dynactin p62 subunit, dynactin subunit p62
Emond M, Louie T, Emerson J, Chong J, Mathias R, Knowles M, et al
. Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis. PLoS Genet. 2015;11:e1005273 pubmed publisher
..design) maximizes power and this approach was recently validated empirically with the discovery of variants in DCTN4 that influence the natural history of P...
Valls SerÃ³n M, Ferwerda B, Engelen Lee J, Geldhoff M, Jaspers V, Zwinderman A, et al
. V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. Acta Neuropathol Commun. 2016;4:50 pubmed publisher
..genetic association study using the Human Exome BeadChip and identified gene variants in encoding dynactin 4 (DCTN4), retinoic acid early transcript 1E (RAET1E), and V-akt murine thymoma viral oncogene homolog 3 (AKT3) to be ..
Bingham J, Schroer T. Self-regulated polymerization of the actin-related protein Arp1. Curr Biol. 1999;9:223-6 pubmed
..Arp1 filament is bounded by actin-capping protein at one end and a heterotetrameric protein complex containing the p62 subunit (D.M. Eckley, S.R. Gill, J.B.B., J.E. Heuser, T.A.S., unpublished observations) at the other ...
Karki S, Tokito M, Holzbaur E. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. J Biol Chem. 2000;275:4834-9 pubmed
..Using a dynein affinity column, the previously uncharacterized p62 subunit of dynactin was isolated and microsequenced...
Lim C, Cater M, Mercer J, La Fontaine S. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. J Biol Chem. 2006;281:14006-14 pubmed
..The dynactin subunit p62 (dynactin 4; DCTN4) was identified as an interacting partner, and this interaction was confirmed by co-..
Ayalon G, Davis J, Scotland P, Bennett V. An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. Cell. 2008;135:1189-200 pubmed publisher
..Dynactin-4 and a subset of microtubules disappear from sarcolemmal sites in ankyrin-B-depleted muscle. Ankyrin-B thus is an adaptor required for sarcolemmal localization of dystrophin, as well as dynactin-4...
Boultwood J, Fidler C, Strickson A, Watkins F, Kostrzewa M, Jaju R, et al
. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. Genomics. 2000;66:26-34 pubmed
..Genomic localization and expression patterns would suggest that the 8 novel cDNAs described in this report represent potential candidate genes for the 5q- syndrome. ..
Emond M, Louie T, Emerson J, Zhao W, Mathias R, Knowles M, et al
. Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Nat Genet. 2012;44:886-9 pubmed publisher
..NHLBI) Exome Sequencing Project (ESP), we used an extreme phenotype study design to discover that variants in DCTN4, encoding a dynactin protein, are associated with time to first P. aeruginosa airway infection, chronic P...
Viel M, Hubert D, Burgel P, GÃ©nin E, HonorÃ© I, Martinez B, et al
. DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Clin Respir J. 2016;10:777-783 pubmed publisher
..By using exome sequencing and extreme phenotype design, it was recently shown that isoforms of dynactin 4 (DCTN4) may influence Pa infection in CF, leading to worse respiratory disease...