Gene Symbol: DCTN4
Description: dynactin subunit 4
Alias: DYN4, P62, dynactin subunit 4, dynactin 4 (p62), dynactin p62 subunit, dynactin subunit p62
Species: human
Products:     DCTN4

Top Publications

  1. Emond M, Louie T, Emerson J, Chong J, Mathias R, Knowles M, et al. Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis. PLoS Genet. 2015;11:e1005273 pubmed publisher
    ..design) maximizes power and this approach was recently validated empirically with the discovery of variants in DCTN4 that influence the natural history of P...
  2. Valls Serón M, Ferwerda B, Engelen Lee J, Geldhoff M, Jaspers V, Zwinderman A, et al. V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. Acta Neuropathol Commun. 2016;4:50 pubmed publisher
    ..genetic association study using the Human Exome BeadChip and identified gene variants in encoding dynactin 4 (DCTN4), retinoic acid early transcript 1E (RAET1E), and V-akt murine thymoma viral oncogene homolog 3 (AKT3) to be ..
  3. Bingham J, Schroer T. Self-regulated polymerization of the actin-related protein Arp1. Curr Biol. 1999;9:223-6 pubmed
    ..Arp1 filament is bounded by actin-capping protein at one end and a heterotetrameric protein complex containing the p62 subunit (D.M. Eckley, S.R. Gill, J.B.B., J.E. Heuser, T.A.S., unpublished observations) at the other [8]...
  4. Karki S, Tokito M, Holzbaur E. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. J Biol Chem. 2000;275:4834-9 pubmed
    ..Using a dynein affinity column, the previously uncharacterized p62 subunit of dynactin was isolated and microsequenced...
  5. Lim C, Cater M, Mercer J, La Fontaine S. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. J Biol Chem. 2006;281:14006-14 pubmed
    ..The dynactin subunit p62 (dynactin 4; DCTN4) was identified as an interacting partner, and this interaction was confirmed by co-..
  6. Ayalon G, Davis J, Scotland P, Bennett V. An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. Cell. 2008;135:1189-200 pubmed publisher
    ..Dynactin-4 and a subset of microtubules disappear from sarcolemmal sites in ankyrin-B-depleted muscle. Ankyrin-B thus is an adaptor required for sarcolemmal localization of dystrophin, as well as dynactin-4...
  7. Boultwood J, Fidler C, Strickson A, Watkins F, Kostrzewa M, Jaju R, et al. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. Genomics. 2000;66:26-34 pubmed
    ..Genomic localization and expression patterns would suggest that the 8 novel cDNAs described in this report represent potential candidate genes for the 5q- syndrome. ..
  8. Emond M, Louie T, Emerson J, Zhao W, Mathias R, Knowles M, et al. Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Nat Genet. 2012;44:886-9 pubmed publisher
    ..NHLBI) Exome Sequencing Project (ESP), we used an extreme phenotype study design to discover that variants in DCTN4, encoding a dynactin protein, are associated with time to first P. aeruginosa airway infection, chronic P...
  9. Viel M, Hubert D, Burgel P, Génin E, Honoré I, Martinez B, et al. DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. Clin Respir J. 2016;10:777-783 pubmed publisher
    ..By using exome sequencing and extreme phenotype design, it was recently shown that isoforms of dynactin 4 (DCTN4) may influence Pa infection in CF, leading to worse respiratory disease...