DCT

Summary

Gene Symbol: DCT
Description: dopachrome tautomerase
Alias: TRP-2, TYRP2, L-dopachrome tautomerase, L-dopachrome Delta-isomerase, L-dopachrome isomerase, TRP2, dopachrome delta-isomerase, dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), tyrosinase related protein-2, tyrosine-related protein 2
Species: human
Products:     DCT

Top Publications

  1. Jackson I, Chambers D, Tsukamoto K, Copeland N, Gilbert D, Jenkins N, et al. A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus. EMBO J. 1992;11:527-35 pubmed
    ..Extracts from mice homozygous for the slaty mutation have a 3-fold or more reduction in DT activity, indicating that TRP-2/DT is encoded at the slaty locus, and the missense mutation reduces but does not abolish the enzyme activity. ..
  2. Yokoyama K, Suzuki H, Yasumoto K, Tomita Y, Shibahara S. Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. Biochim Biophys Acta. 1994;1217:317-21 pubmed
    ..Human TRP-2/DOPAchrome tautomerase is composed of 519 amino acids with a molecular weight of 59,000 and has about 84% identity with the mouse counterpart. ..
  3. Bouchard B, del Marmol V, Jackson I, Cherif D, Dubertret L. Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. Eur J Biochem. 1994;219:127-34 pubmed
    ..b>TYRP2 has been mapped to the chromosomal region 13q32, thus extending a region of synteny with mouse-chromosome 14.
  4. Sturm R, O Sullivan B, Box N, Smith A, Smit S, Puttick E, et al. Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. Genomics. 1995;29:24-34 pubmed
    The structures of the human tyrosinase-related protein genes TYRP1 and TYRP2 have been determined and compared with that of the tyrosinase gene (TYR). The TYRP1 protein is encoded in 7 exons spread over 24 kb of genomic DNA...
  5. Wang R, Appella E, Kawakami Y, Kang X, Rosenberg S. Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J Exp Med. 1996;184:2207-16 pubmed
    ..Like other melamona differentiation antigens, TRP-2 was only expressed in melanoma, melanocytes, and retina, but not in other human tissues tested. ..
  6. Alonso S, Izagirre N, Smith Zubiaga I, Gardeazabal J, Díaz Ramón J, Diaz Perez J, et al. Complex signatures of selection for the melanogenic loci TYR, TYRP1 and DCT in humans. BMC Evol Biol. 2008;8:74 pubmed publisher
    ..TYR, TYRP1 and DCT were among the five most differently expressed genes between these two groups...
  7. Metwalley K, Farghaly H, Sherief T. Plasma adrenomedullin level in children with obesity: relationship to left ventricular function. World J Pediatr. 2018;14:84-91 pubmed publisher
    ..01), prolonged mitral deceleration time (DcT) (P = 0.01) and reduced ratio of mitral E-to-mitral A-wave peak velocity (P = 0...
  8. Yousef H, Aboelwafa H. The potential protective role of taurine against 5-fluorouracil-induced nephrotoxicity in adult male rats. Exp Toxicol Pathol. 2017;69:265-274 pubmed publisher
    ..Also, the proximal (PCT) and distal (DCT) convoluted tubules showed thickened basement membranes, destructed apical microvilli and loss of basal infoldings ..
  9. Nie M, Bal M, Liu J, Yang Z, Rivera C, Wu X, et al. Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6). J Biol Chem. 2018;293:16488-16502 pubmed publisher
    ..Magnesium absorption is fine-tuned in the distal convoluted tubule (DCT) via the apical magnesium channel transient receptor potential melastatin 6 (TRPM6)...

More Information

Publications123 found, 100 shown here

  1. Seberg H, Van Otterloo E, Loftus S, Liu H, Bonde G, Sompallae R, et al. TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genet. 2017;13:e1006636 pubmed publisher
    ..find that expression of a small subset of genes underlying pigmentation phenotypes is TFAP2A-dependent, including Dct, Mc1r, Mlph, and Pmel...
  2. Nishimoto M, Fujita T. Renal mechanisms of salt-sensitive hypertension: contribution of two steroid receptor-associated pathways. Am J Physiol Renal Physiol. 2015;308:F377-87 pubmed publisher
    ..GR)-with-no-lysine kinase (WNK)4-Na(+)-Cl(-) cotransporter pathway, which is active in distal convoluted tubule (DCT)1, and the Ras-related C3 botulinum toxin substrate (Rac)1-mineralocorticoid receptor (MR) pathway, which is active ..
  3. Taymaz Nikerel H, De Mey M, Baart G, Maertens J, Foulquié Moreno M, Charlier D, et al. Comparative fluxome and metabolome analysis for overproduction of succinate in Escherichia coli. Biotechnol Bioeng. 2016;113:817-29 pubmed publisher
    ..the conditions investigated: increased expression of a succinate exporter (DcuC), deletion of a succinate importer (Dct), deletion of succinate dehydrogenase (SUCDH) and expression of a PEP carboxylase (PPC) with increased capacity due ..
  4. Wang X, Shi Y, Zhou Q, Liu X, Xu S, Lei T. Detailed histological structure of human hair follicle bulge region at different ages: a visible niche for nesting adult stem cells. J Huazhong Univ Sci Technolog Med Sci. 2012;32:648-656 pubmed publisher
    ..Gene expression profile analysis revealed that there were cells with mRNA transcripts of Dct(Hi)Tyrase(Lo)-Tyrp1(Lo)MC1R(Lo)MITF(Lo)/K15(Hi)/NPNT(Hi) in the bulge region of the hair follicle with ..
  5. Civelek M, Mehrkens J, Carstens N, Fitzenberger E, Wenzel U. Inhibition of mitophagy decreases survival of Caenorhabditis elegans by increasing protein aggregation. Mol Cell Biochem. 2018;: pubmed publisher
    ..RNA interference for dct-1, drp-1, eat-3, fis-1, fzo1, glb-1, pink-1, and pgam-5 all resulted in a significant reduction of survival time at ..
  6. Salloum T, Tannous E, Alousi S, Arabaghian H, Rafei R, Hamze M, et al. Genomic mapping of ST85 blaNDM-1 and blaOXA-94 producing Acinetobacter baumannii isolates from Syrian Civil War Victims. Int J Infect Dis. 2018;74:100-108 pubmed publisher
    ..Tn125 carrying blaNDM-1 was truncated by the insertion of ISAba14 downstream of dct, generating ?Tn125. blaOXA-94 was upstream of ISAba13 and ISAba17...
  7. Hong C, Saint Jeannet J. The b-HLH transcription factor Hes3 participates in neural plate border formation by interfering with Wnt/?-catenin signaling. Dev Biol. 2018;442:162-172 pubmed publisher
    ..sox8 and sox10 expression, associated with an increase in genes important for melanocytes differentiation (mitf and dct)...
  8. Ju Y, Ge J, Ren X, Zhu X, Xue Z, Feng Y, et al. Cav1.2 of L-type Calcium Channel Is a Key Factor for the Differentiation of Dental Pulp Stem Cells. J Endod. 2015;41:1048-55 pubmed publisher
    ..In this study, we examined the function of LTCC α1C subunit (Cav1.2) and its distal C-terminus (DCT) during the in vitro differentiation of rat DPSCs (rDPSCs)...
  9. Hirobe T, Shibata T, Sato K. Human fibroblasts treated with hydrogen peroxide stimulate human melanoblast proliferation and melanocyte differentiation, but inhibit melanocyte proliferation in serum-free co-culture system. J Dermatol Sci. 2016;84:282-295 pubmed publisher
    ..the expression of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and KIT was increased, whereas TYRP2 and microphthalmia-associated transcription factor showed no change...
  10. Metwalley K, Farghaly H, Sherief T. Left ventricular dysfunction and subclinical atherosclerosis in children with classic congenital adrenal hyperplasia: a single-center study from upper Egypt. Eur J Pediatr. 2016;175:405-12 pubmed publisher
    ..001), indicating LV hypertrophy; and lower ratio of E/A wave and prolonged mitral deceleration time (DcT) and isovolumic relaxation times (IVRTs) (p < 0.001), indicating LV dysfunction...
  11. Badaoui B, Manunza A, Castelló A, D Andrea M, Pilla F, Capote J, et al. Technical note: Advantages and limitations of authenticating Palmera goat dairy products by pyrosequencing the melanocortin 1 receptor (MC1R) gene. J Dairy Sci. 2014;97:7293-7 pubmed publisher
    ..Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), tyrosinase (TYR), and tyrosinase-related protein 2 (TYRP2)]...
  12. Nguyen M, Han J, Ralph D, Veiras L, McDonough A. Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron. Physiol Rep. 2015;3: pubmed publisher
    ..of PT Na(+)/H(+) exchanger 3 (NHE3), cortical TALH Na-K-2Cl cotransporter 2 (NKCC2), distal convoluted tubule (DCT) Na-Cl cotransporter (NCC), and cortical CD ENaC subunits...
  13. Wasserman B, Carvajal Hausdorf D, Ho K, Wong W, Wu N, Chu V, et al. High concordance of a closed-system, RT-qPCR breast cancer assay for HER2 mRNA, compared to clinically determined immunohistochemistry, fluorescence in situ hybridization, and quantitative immunofluorescence. Lab Invest. 2017;97:1521-1526 pubmed publisher
    ..25% (sensitivity=0.87; specificity=0.94; PPV=0.89; NPV=0.92) using a pre-defined delta Ct cut-off (dCt?-1) for HER2. Concordance (OPA) between RT-qPCR and QIF was 94% (sensitivity=0.90; specificity=0.96; PPV=0...
  14. Bourhim T, Villareal M, Gadhi C, Hafidi A, Isoda H. Depigmenting effect of argan press-cake extract through the down-regulation of Mitf and melanogenic enzymes expression in B16 murine melanoma cells. Cytotechnology. 2018;: pubmed publisher
    ..the mechanism involved, the expression level of melanogenic enzymes tyrosinase (TYR), dopachrome tautomerase (DCT), and tyrosinase-related protein 1 (TRP1) were determined and mRNA expression level of microphthalmia- associated ..
  15. Zhu W, Liu L, Wang X, Gao X, Jiang J, Wang B. Transcriptomics reveals the molecular processes of light-induced rapid darkening of the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura) and their genetic basis of pigmentation strategy. BMC Genomics. 2018;19:422 pubmed publisher
    ..Genes involved in melanogenesis (i.e. TYR, TYRP1 and DCT) and melanocyte proliferation, as well as their transcriptional factor (MITF), showed light-induced transcription, ..
  16. Zhou J, Ling J, Ping F. Interferon-? Attenuates 5-Hydroxytryptamine-Induced Melanogenesis in Primary Melanocyte. Biol Pharm Bull. 2016;39:1091-9 pubmed publisher
    ..factor (MITF) and its downstream TYR, tyrosinase-related protein 1 (TRP-1) and dopachrome tautomerase (DCT). We proved here that 5-HTR1A/2A participated in the regulation of melanogenesis...
  17. Beigi Burujeny S, Atai M, Yeganeh H. Assessments of antibacterial and physico-mechanical properties for dental materials with chemically anchored quaternary ammonium moieties: thiol-ene-methacrylate vs. conventional methacrylate system. Dent Mater. 2015;31:244-61 pubmed publisher
    ..Quantitative assay of antibacterial activity was evaluated through direct contact test (DCT) against S. mutans...
  18. Du B, Liu X, Zhang P, Zhang J, Ji K, Hu S, et al. The role of sex-determining region Y-box 6 in melanogenesis in alpaca melanocytes. J Dermatol Sci. 2018;91:268-275 pubmed publisher
    ..transcription factor (MITF), tyrosinase (TYR), tyrosine related protein-1 (TYRP1), and dopachrome-tautomerase (DCT), whereas ?-catenin levels decreased in SOX6-overexpressing melanocytes...
  19. Gong S, Huang Z, Shi W, Ma B, Tay F, Zhou B. In vitro evaluation of antibacterial effect of AH Plus incorporated with quaternary ammonium epoxy silicate against Enterococcus faecalis. J Endod. 2014;40:1611-5 pubmed publisher
    ..faecalis by the direct contact test (DCT) and 3-dimensional image analysis of live/dead-stained E...
  20. Zhang Y, Liu J, Fu W, Xu W, Zhang H, Chen S, et al. Comparative Transcriptome and DNA methylation analyses of the molecular mechanisms underlying skin color variations in Crucian carp (Carassius carassius L.). BMC Genet. 2017;18:95 pubmed publisher
    ..color development were further identified by quantitative polymerase chain reaction, such as mitfa, tyr, tyrp1, and dct, which were down-regulated, and foxd3, hpda, ptps, and gch1, which were up-regulated...
  21. Schiavi A, Maglioni S, Palikaras K, Shaik A, Strappazzon F, Brinkmann V, et al. Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans. Curr Biol. 2015;25:1810-22 pubmed publisher
    ..elegans in response to mitochondrial stress in a pdr-1/Parkin-, pink-1/Pink-, and dct-1/Bnip3-dependent manner...
  22. Koumangoye R, Delpire E. DNPEP is not the only peptidase that produces SPAK fragments in kidney. Physiol Rep. 2017;5: pubmed publisher
    ..This kinase phosphorylates and activates the apical Na-Cl cotransporter in the DCT. Western blot analysis reveals that SPAK in kidney exists as a full-length protein as well as shorter fragments ..
  23. Fang E, Bohr V. NAD+: The convergence of DNA repair and mitophagy. Autophagy. 2017;13:442-443 pubmed publisher
    ..can clear accumulated dysfunctional mitochondria through restoration of compromised mitophagy via upregulation of DCT-1...
  24. Yue Z, Shi Z, Hu B, Wang Z, DU Y. [L-VDCC autoregulation abnormality contributes to calcium overload in myocardial ischemia-reperfusion injury]. Sheng Li Xue Bao. 2017;69:861-869 pubmed
    ..inactivation (CDI), advancing calcium-dependent facilitation (CDF), and weakening distal carboxy terminus (DCT) inhibition...
  25. Yetter E, Brazg J, Del Valle D, Mulvey L, Dickman E. Delayed cardiac tamponade: A rare but life-threatening complication of catheter ablation. Am J Emerg Med. 2017;35:803.e1-803.e3 pubmed publisher
    Delayed cardiac tamponade (DCT) is a rare and life-threatening complication of catheter ablation performed as a treatment of atrial fibrillation, with few cases described in the medical literature...
  26. Detorakis E, Tsaglioti E, Kymionis G. Non-Invasive Ocular Rigidity Measurement: A Differential Tonometry Approach. Acta Medica (Hradec Kralove). 2015;58:92-7 pubmed publisher
    ..deforms the corneal apex and displaces volume from the anterior segment whereas Dynamic Contour Tonometry (DCT) does not, we aimed at developing an algorithm for the calculation of ocular rigidity (OR) based on the differences ..
  27. Chang Y, Huang H, Yeh K, Chang J. Identification of novel mutations in endometrial cancer patients by whole-exome sequencing. Int J Oncol. 2017;50:1778-1784 pubmed publisher
    ..IL24, MCM6, TSC1, BIRC2, CIITA, DST, CASP8 and NOTCH2) and 21 potential passenger genes (ARMCX4, IGSF10, VPS13C, DCT, DNAH14, TLN1, ZNF605, ZSCAN29, MOCOS, CMYA5, PCDH17, UGT1A8, CYFIP2, MACF1, NUDT5, JAKMIP1, PCDHGB4, FAM178A, SNX6,..
  28. Sapriel G, Konjek J, Orgeur M, Bouri L, Frézal L, Roux A, et al. Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications. BMC Genomics. 2016;17:118 pubmed publisher
    ..genomic architecture of the highly recombinogenic strains is consistent with the distributive conjugal transfer (DCT) observed in M. smegmatis. Intriguingly, no known DCT function was found in M...
  29. Mahmoodzadeh S, Haase H, Sporbert A, Rharass T, Panáková D, Morano I. Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17β-estradiol. J Mol Cell Cardiol. 2016;97:226-34 pubmed publisher
    ..Several studies showed that the distal C-terminus fragment of Cav1.2 α1C subunit (α1C-dCT) is proteolytically cleaved and shuttles between the plasma membrane and the nucleus, which is regulated both ..
  30. Salazar C, Mulligan K, Webbe F. Updating the Rey Dot Counting Test for Use in Collegiate Baseline Concussion Testing. Dev Neuropsychol. 2017;42:83-92 pubmed publisher
    ..In order to help prevent this from occurring, the Rey Dot Counting Test (DCT) was examined as a potential measure to be added to a Division II university screening battery...
  31. Tsai W, Chan Y, Hsueh C, Everett T, Chang P, Choi E, et al. Small conductance calcium-activated potassium current and the mechanism of atrial arrhythmia in mice with dysfunctional melanocyte-like cells. Heart Rhythm. 2016;13:1527-35 pubmed publisher
    The melanin synthesis enzyme dopachrome tautomerase (Dct) regulates intracellular Ca(2+) in melanocytes. Homozygous Dct knockout (Dct(-/-)) adult mice are vulnerable to atrial arrhythmias (AA)...
  32. Nagao M, Yamasaki Y, Kamitani T, Kawanami S, Sagiyama K, Yamanouchi T, et al. Quantification of coronary flow using dynamic angiography with 320-detector row CT and motion coherence image processing: Detection of ischemia for intermediate coronary stenosis. Eur J Radiol. 2016;85:996-1003 pubmed publisher
    ..is to propose a new method for quantifying coronary flow using dynamic CT angiography for the whole heart (heart-DCT) and investigate its ability for detecting ischemia from intermediate coronary stenosis...
  33. San Jose L, Ducrest A, Ducret V, Simon C, Richter H, Wakamatsu K, et al. MC1R variants affect the expression of melanocortin and melanogenic genes and the association between melanocortin genes and coloration. Mol Ecol. 2017;26:259-276 pubmed publisher
    ..not only associated with an expected lower expression of melanogenic-related genes (TYR, TYRP1, OCA2, SLC45A2, KIT, DCT) but also with a lower MC1R expression and a higher expression of ASIP, the MC1R antagonist...
  34. Shi Z, Ji K, Yang S, Zhang J, Yao J, Dong C, et al. Biological characteristics of mouse skin melanocytes. Tissue Cell. 2016;48:114-20 pubmed publisher
    ..for the melanocyte specific markers including S-100 antigen, TYR, tyrosinase related protein 1 (TYRP1), tyrosinase related protein 2 (TYRP2) and micropthalmia associated transcription factor (MITF) confirmed purity and melanogenic ..
  35. Fuji T, Nakamura Y, Fukumoto W, Kajiwara K, Chosa K, Tani C, et al. Clinical Indication for Computed Tomography During Hepatic Arteriography (CTHA) in Addition to Dynamic CT Studies to Identify Hypervascularity of Hepatocellular Carcinoma. Cardiovasc Intervent Radiol. 2018;41:618-627 pubmed publisher
    ..We retrospectively divided 45 patients with HCC, who underwent both dynamic CT (dCT) and CTHA, into two groups based on the number of hypervascular HCCs identified on dCT and CTHA studies...
  36. Guillot R, Muriach B, Rocha A, Rotllant J, Kelsh R, Cerdá Reverter J. Thyroid Hormones Regulate Zebrafish Melanogenesis in a Gender-Specific Manner. PLoS ONE. 2016;11:e0166152 pubmed publisher
    ..We also found sexually dimorphic regulation of some melanogenic genes, such as Dct/Tyrp2 that was dramatically up-regulated in females after T3 treatment...
  37. Kim Y, Lee S, Sung Y, Lee B. Assessment of osteoporosis using pelvic diagnostic computed tomography. J Bone Miner Metab. 2016;34:457-63 pubmed publisher
    ..from dual energy X-ray absorptiometry (DXA) and Hounsfield unit (HU) from pelvic diagnostic computed tomography (dCT), and to evaluate whether HU could be used to identify osteoporosis...
  38. Jóhannesson G, Hallberg P, Ambarki K, Eklund A, Lindén C. Age-dependency of ocular parameters: a cross sectional study of young and elderly healthy subjects. Graefes Arch Clin Exp Ophthalmol. 2015;253:1979-83 pubmed publisher
    ..with four tonometry methods in a standardized order: ocular response analyser (ORA), dynamic contour tonometry (DCT), applanation resonance tonometry (ART) and Goldmann applanation tonometry (GAT)...
  39. Lee C, Ng H, Lee Y, Lai L, Lien Y. The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop and thiazide diuretics. Am J Physiol Renal Physiol. 2016;310:F230-6 pubmed publisher
    Calbindin-D28k (CBD-28k) is a calcium binding protein located in the distal convoluted tubule (DCT) and plays an important role in active calcium transport in the kidney...
  40. Yang S, Zhang J, Ji K, Jiao D, Fan R, Dong C. Characterization and expression of soluble guanylate cyclase in skins and melanocytes of sheep. Acta Histochem. 2016;118:219-24 pubmed publisher
    ..microphthalmia transcription factor (MITF), tyrosinase (TYR), tyrosinase related protein 1(TYRTP1), and tyrosinase related protein 2(TYRP2) both at mRNA and protein level. Moreover, the melanocytes was capable of producing cGMP and cAMP...
  41. Herdener S, Hafizovic D, Pache M, Lautebach S, Funk J. Is the PASCAL-Tonometer suitable for measuring intraocular pressure in clinical routine? Long- and short-term reproducibility of dynamic contour tonometry. Eur J Ophthalmol. 2008;18:39-43 pubmed
    Dynamic contour tonometry (DCT) is a new technique to measure intraocular pressure (IOP). In several studies no correlation between IOP values and corneal thickness was shown with DCT...
  42. Bhatt A, Lesko A, Lucas L, Kansara A, Baraban E. Patients with Low National Institutes of Health Stroke Scale Scores Have Longer Door-to-Needle Times: Analysis of a Telestroke Network. J Stroke Cerebrovasc Dis. 2016;25:2253-8 pubmed publisher
    ..regression models were used to assess the effect of NIHSS scores on DTN and its 2 components: door-to-CT (DCT) and CT-to-needle (CTN) times. We identified 692 AIS patients who received IV-tPA within 4...
  43. Acan D, Karti O, Kusbeci T. Evaluation of ocular pulse amplitude in non-arteritic anterior ischaemic optic neuropathy. BMC Ophthalmol. 2017;17:33 pubmed publisher
    ..Bilateral OPA was measured with dynamic contour tonometry (DCT) and was compared between the study and control groups...
  44. Periyakoil V, Kraemer H, Noda A. Creation and the empirical validation of the dignity card-sort tool to assess factors influencing erosion of dignity at life's end. J Palliat Med. 2009;12:1125-30 pubmed publisher
    ..The key item in each factor as identified by the PCA was used to create the final 6-item dignity card-sort tool (DCT). The DCT was also administered to physicians caring for palliative care patients (n = 21)...
  45. Tsuda H, Hirakawa A, Kotani T, Sumigama S, Mano Y, Nakano T, et al. Risk assessment for neonatal RDS/TTN using gestational age and the amniotic lamellar body count in twin pregnancies. Clin Chim Acta. 2015;451:301-4 pubmed publisher
    ..Six hundred thirty-two amniotic fluid samples, comprising 169 dichorionic twin (DCT) and 147 monochorionic twin (MCT) gestations, were obtained at Cesarean section...
  46. Wang J, Chen H, Wang Y, Wang X, Chen H, Zhang M, et al. Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. BMC Syst Biol. 2017;11:103 pubmed publisher
    ..and Kaempferide significantly increased the expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT) and the tyrosinase activity in B16F10 cells...
  47. Velazquez H, Silva T, Andujar E, Desir G, Ellison D, Greger R. The distal convoluted tubule of rabbit kidney does not express a functional sodium channel. Am J Physiol Renal Physiol. 2001;280:F530-9 pubmed
    We sought to assess whether the distal convoluted tubule (DCT) segment of the rabbit nephron expresses a functional epithelial sodium channel. First, the transepithelial voltage (V(te), lumen vs...
  48. Ramakrishnan A, Abhiram B, Prasanna S. Voice source characterization using pitch synchronous discrete cosine transform for speaker identification. J Acoust Soc Am. 2015;137:EL469-75 pubmed publisher
    A characterization of the voice source (VS) signal by the pitch synchronous (PS) discrete cosine transform (DCT) is proposed...
  49. Wang Y, Tong L, Jiang M, Zheng J. Non-rigid structure estimation in trajectory space from monocular vision. Sensors (Basel). 2015;15:25730-45 pubmed publisher
    ..Approach (PTA), based on characteristic points' trajectories described by a predefined Discrete Cosine Transform (DCT) basis, the structure matrix was also calculated by using a factorization method...
  50. Yu L, Han Q, Niu X, Yiu S, Fang J, Zhang Y. An improved parameter estimation scheme for image modification detection based on DCT coefficient analysis. Forensic Sci Int. 2016;259:200-9 pubmed publisher
    Most of the existing image modification detection methods which are based on DCT coefficient analysis model the distribution of DCT coefficients as a mixture of a modified and an unchanged component...
  51. Fang E, Palikaras K, Sun N, Fivenson E, Spangler R, Kerr J, et al. In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice. J Vis Exp. 2017;: pubmed publisher
    ..g., Rosella and DCT-1/ LGG-1 strains), and mice (mt-Keima)...
  52. Atri M, Zhang Z, Dehdashti F, Lee S, Ali S, Marques H, et al. Utility of PET-CT to evaluate retroperitoneal lymph node metastasis in advanced cervical cancer: Results of ACRIN6671/GOG0233 trial. Gynecol Oncol. 2016;142:413-9 pubmed publisher
    ..Patients underwent concurrent diagnostic contrast-enhanced CT (DCT) and PET and pelvic/abdominal lymphadenectomy...
  53. Wachtl J, Toteberg Harms M, Frimmel S, Kniestedt C. [Evaluation of correction formulas for tonometry : The Goldmann applanation tonometry in approximation to dynamic contour tonometry]. Ophthalmologe. 2016;: pubmed
    ..The IOP was measured with GAT and dynamic contour tonometry (DCT) in randomized order. The GAT readings were adjusted with five correction equations...
  54. Yamauchi T, Yamasaki K, Tsuchiyama K, Koike S, Aiba S. A quantitative analysis of multilineage-differentiating stress-enduring (Muse) cells in human adipose tissue and efficacy of melanocytes induction. J Dermatol Sci. 2017;86:198-205 pubmed publisher
    ..Adipose-Muse cells sequentially expressed melanocyte-related genes including KIT, MITF, TYRP1 PMEL, DCT, melanocortin 1 receptor (MC1R), and TYR at a comparable level to melanocytes during 6-week culture...
  55. Scherzer P, Gal Moscovici A, Sheikh Hamad D, Popovtzer M. Sodium-pump gene-expression, protein abundance and enzyme activity in isolated nephron segments of the aging rat kidney. Physiol Rep. 2015;3: pubmed publisher
    ..and protein abundance (immunoblotting) were quantitated in the following isolated nephron segments: PCT, PST, MTAL, DCT, and CCD from 2, 8, 15, and 24 month-old-rats. In the course of aging, creatinine clearance decreased from 0...
  56. Okamura K, Hayashi M, Abe Y, Araki Y, Hozumi Y, Suzuki T. Microsatellite polymorphism located immediately upstream of the phosphatidylinositol glycan, class K gene (PIGK) affects its expression, which correlates with tyrosinase activity in human melanocytes. J Dermatol Sci. 2017;85:131-134 pubmed publisher
    ..glycan, class A, and class K gene (PIGA, PIGK)] and melanogenesis-related genes (MITF, TYRP1, TYRP2, and TYR) as well as DOPA oxidase activities were evaluated in 13 different normal human epidermal melanocytes (..
  57. Schleiss M, Berka U, Watson E, Aistleithner M, Kiefmann B, Mangeat B, et al. Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. Clin Vaccine Immunol. 2017;24: pubmed publisher
    ..on nonreplicating lymphocytic choriomeningitis virus (rLCMV) vectors expressing a cytoplasmic tail-deleted gB [gB(dCt)] and full-length pp65 from human CMV in mice...
  58. Wu N, Huang H, Min T, Hu H. TAR cloning and integrated overexpression of 6-demethylchlortetracycline biosynthetic gene cluster in Streptomyces aureofaciens. Acta Biochim Biophys Sin (Shanghai). 2017;:1-6 pubmed publisher
    6-Demethylchlortetracycline (6-DCT), a tetracycline antibiotic produced by Streptomyces aureofaciens, is a crucial precursor employed for the semi-synthesis of tigecycline, minocycline, and amadacyclin (PTK 0796)...
  59. Vanhoudt A, van Hees Huijps K, van Knegsel A, Sampimon O, Vernooij J, Nielen M, et al. Effects of reduced intramammary antimicrobial use during the dry period on udder health in Dutch dairy herds. J Dairy Sci. 2018;101:3248-3260 pubmed publisher
    Dry cow therapy (DCT) in the Netherlands changed from mainly blanket to selective antimicrobial DCT...
  60. Filimon A, Zurac S, Milac A, Sima L, Petrescu S, Negroiu G. Value of dopachrome tautomerase detection in the assessment of melanocytic tumors. Melanoma Res. 2014;24:219-36 pubmed publisher
    Dopachrome tautomerase (DCT) and tyrosinase (Tyr) are melanogenic enzymes and structurally related melanosomal proteins...
  61. Michard Q, Commo S, Rocchetti J, El Houari F, Alleaume A, Wakamatsu K, et al. TRP-2 expression protects HEK cells from dopamine- and hydroquinone-induced toxicity. Free Radic Biol Med. 2008;45:1002-10 pubmed publisher
    We previously reported that melanogenic enzyme TRP-2 (or DCT for DOPAchrome tautomerase) expression in WM35 melanoma cells resulted in increased intracellular GSH levels, reduction in DNA damage induced by free radicals, and decreased ..
  62. Tobin D, Quinn A, Ito S, Thody A. The presence of tyrosinase and related proteins in human epidermis and their relationship to melanin type. Pigment Cell Res. 1994;7:204-9 pubmed
  63. Takeda K, Yokoyama S, Yasumoto K, Saito H, Udono T, Takahashi K, et al. OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium. Biochem Biophys Res Commun. 2003;300:908-14 pubmed
    ..These RPE cells express DOPAchrome tautomerase (DCT) that is an enzyme involved in melanin biosynthesis...
  64. Michard Q, Commo S, Belaidi J, Alleaume A, Michelet J, Daronnat E, et al. TRP-2 specifically decreases WM35 cell sensitivity to oxidative stress. Free Radic Biol Med. 2008;44:1023-31 pubmed publisher
    ..Nevertheless, these properties appeared to depend on a particular cell environment because expression of TRP-2 failed to rescue HEK epithelial cells exposed to similar treatments. ..
  65. Gullbrand S, Schaer T, Agarwal P, Bendigo J, Dodge G, Chen W, et al. Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model. Acta Biomater. 2017;60:201-209 pubmed publisher
    ..feasibility of a triple interpenetrating network hydrogel composed of dextran, chitosan, and teleostean (DCT) for augmentation of the degenerative NP in a preclinical goat model...
  66. Saenz Frances F, Sanz Pozo C, Borrego Sanz L, Jañez L, Morales Fernandez L, Martínez de la Casa J, et al. Dependence of dynamic contour and Goldmann applanation tonometries on peripheral corneal thickness. Int J Ophthalmol. 2017;10:1521-1527 pubmed publisher
    To determine the effects of peripheral corneal thickness (PCT) on dynamic contour tonometry(DCT) and Goldmann applanation tonometry (GAT).
  67. Bernd A, Ramirez Bosca A, Kippenberger S, Martinez Liarte J, Holzmann H, Solano F. Levels of dopachrome tautomerase in human melanocytes cultured in vitro. Melanoma Res. 1994;4:287-91 pubmed
    Several reports have been published about the level of activity and possible functions of dopachrome tautomerase (DCT) in mouse melanoma cells...
  68. Sturm R, Baker E, Sutherland G. Assignment of the tyrosinase-related protein-2 gene (TYRP2) to human chromosome 13q31-q32 by fluorescence in situ hybridization: extended synteny with mouse chromosome 14. Genomics. 1994;21:293-6 pubmed
  69. Pisarra P, Lupetti R, Palumbo A, Napolitano A, Prota G, Parmiani G, et al. Human melanocytes and melanomas express novel mRNA isoforms of the tyrosinase-related protein-2/DOPAchrome tautomerase gene: molecular and functional characterization. J Invest Dermatol. 2000;115:48-56 pubmed
    ..The pattern of expression of these isoforms suggest that they might play a part in the normal pathway of melanin biosynthesis. ..
  70. Virador V, Matsunaga N, Matsunaga J, Valencia J, Oldham R, Kameyama K, et al. Production of melanocyte-specific antibodies to human melanosomal proteins: expression patterns in normal human skin and in cutaneous pigmented lesions. Pigment Cell Res. 2001;14:289-97 pubmed
    ..the human melanocyte-specific markers, tyrosinase, tyrosinase-related protein (TYRP1), Dopachrome tautomerase (DCT) and Pmel17 (SILV, also known as GP100)...
  71. Liu G, Khong H, Wheeler C, Yu J, Black K, Ying H. Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target in patients with malignant glioma. J Immunother. 2003;26:301-12 pubmed
    ..The authors' studies demonstrate that TRP-2 could be a useful antigen target for monitoring or developing immunotherapeutic strategies for glioma patients. ..
  72. Jiao Z, Zhang Z, Hornyak T, Hozeska A, Zhang R, Wang Y, et al. Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferation. Dev Biol. 2006;296:396-408 pubmed
    DOPAchrome tautomerase (Dct) functions downstream of tyrosinase in the biosynthetic pathway of eumelanin by catalyzing the conversion of dopachrome to 5,5-dihydroxyindole-2-carboxylic acid (DHICA) in pigment cells...
  73. Adams S, Lowes M, O Neill D, Schachterle S, Romero P, Bhardwaj N. Lack of functionally active Melan-A(26-35)-specific T cells in the blood of HLA-A2+ vitiligo patients. J Invest Dermatol. 2008;128:1977-80 pubmed publisher
  74. Oncel B, Dinc U, Orge F, Yalvac B. Comparison of IOP measurement by ocular response analyzer, dynamic contour, Goldmann applanation, and noncontact tonometry. Eur J Ophthalmol. 2009;19:936-41 pubmed
    To assess the agreement among ocular response analyzer (ORA), dynamic contour tonometry (DCT), Goldmann applanation tonometry (GAT), and noncontact tonometry (NCT), and to determine the effects of central corneal thickness (CCT) and ..
  75. Brock S, Rendon B, Yaddanapudi K, Mitchell R. Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas. J Biol Chem. 2012;287:37917-25 pubmed publisher
    ..Combined, these studies indicate that MIF and d-DT cooperate to inhibit AMPK activation in an LKB1-independent manner. ..
  76. Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, et al. Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice. Biochem Biophys Res Commun. 2017;487:368-374 pubmed publisher
    ..leading to abnormal over-activation of the WNK-OSR1/SPAK-NCC cascade in the kidney's distal convoluted tubules (DCT). KLHL2, which is highly homologous to KLHL3, was reported to ubiquitinate and degrade WNKs in vitro...
  77. Kittikulsuth W, Friedman P, Van Hoek A, Gao Y, Kohan D. Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells. BMC Nephrol. 2017;18:292 pubmed publisher
    The distal convoluted tubule (DCT) is an important nephron site for parathyroid hormone (PTH) and calcitonin regulation of urinary divalent cation excretion...
  78. Bonghun Shin -, Soo Jeon -, Jeongwon Ryu -, Hyock Ju Kwon -. Application of compressive sensing to portable ultrasound elastography. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:2992-2995 pubmed publisher
    ..of various CS frameworks associated with three common model bases (Fourier transform, discrete cosine transform (DCT), and wave atom (WA)) and two reconstruction algorithms (?1 minimization and block sparse Bayesian ..
  79. Boyd Shiwarski C, Shiwarski D, Roy A, Namboodiri H, Nkashama L, Xie J, et al. Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent. Mol Biol Cell. 2018;29:499-509 pubmed publisher
    ..In the distal convoluted tubule (DCT), potassium imbalance causes WNK signaling complexes to concentrate into large discrete foci, which we call "WNK ..
  80. Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J. Crystallization and preliminary X-ray analysis of human D-dopachrome tautomerase. J Struct Biol. 1997;120:105-8 pubmed
    ..6 A resolution using a synchrotron radiation source. Crystallization of the selenomethionyl derivative of the protein for applying the multiwavelength anomalous diffraction method was also successful. ..
  81. Lupetti R, Pisarra P, Verrecchia A, Farina C, Nicolini G, Anichini A, et al. Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. J Exp Med. 1998;188:1005-16 pubmed
  82. Loffing J, Loffing Cueni D, Valderrabano V, Kläusli L, Hebert S, Rossier B, et al. Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am J Physiol Renal Physiol. 2001;281:F1021-7 pubmed
    ..The thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC) characterized the distal convoluted tubule (DCT)...
  83. Horie Y, Takemoto Y, Miyazaki A, Namba K, Kase S, Yoshida K, et al. Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. Mol Vis. 2006;12:1601-5 pubmed
    The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT)).
  84. Huang Y, Lee T, Chan K, Hsu F, Wu Y, Lee M. Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes. J Dermatol Sci. 2008;49:115-23 pubmed
    Melanin is the pigment responsible for skin color. Melanin synthesis occurs with the participation of the tyrosinase (TYR) family of proteins including TYR, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2(TRP2/DCT).
  85. Bam M, Bagchi T. Absence of tyrosinase-related protein-2/dopachrome tautomerase transcripts in PBMCs from vitiligo patients. Scand J Immunol. 2009;69:366-73 pubmed publisher
    ..Thus, we conclude that the antigen presenting cells (APC) are not in an activated state and that constitutively activated APC are possibly not required for the progression of the disease once it has been initiated. ..
  86. Aksoy P, Meneses P. The Role of DCT in HPV16 Infection of HaCaTs. PLoS ONE. 2017;12:e0170158 pubmed publisher
    ..Dopachrome tautomerase (DCT) was identified as a cellular gene required for HPV infection in HeLa cells on a siRNA screen study...
  87. Oh T, Lee Y, Lim B, Lim J. Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression. Int J Mol Sci. 2017;18: pubmed publisher
    ..synthesis through the suppression of melanogenesis-stimulating genes such as those encoding dopachrome tautomerase (DCT) and tyrosinase in B16F10 melanoma cells...
  88. Zhang Z, Lei M, Xin H, Hu C, Yang T, Xing Y, et al. Wnt/?-catenin signaling promotes aging-associated hair graying in mice. Oncotarget. 2017;8:69316-69327 pubmed publisher
    ..Here, by using immunostaining and LacZ staining in Dct-LacZ mice, we show that ?-catenin is expressed in melanocytes during hair cycling...
  89. Lai X, Wichers H, Soler Lopez M, Dijkstra B. Structure and Function of Human Tyrosinase and Tyrosinase-related Proteins. Chemistry. 2017;: pubmed publisher
    ..biosynthesis requires three melanogenic enzymes, tyrosinase (TYR), and the tyrosinase-related proteins TYRP1 and TYRP2. The difficulty of isolating pure and homogeneous proteins from endogenous sources has hampered their study, and ..
  90. Park J, Cho H, Kim D. Poly((D,L)lactic-glycolic)acid-star glucose nanoparticles for glucose transporter and hypoglycemia-mediated tumor targeting. Int J Nanomedicine. 2017;12:7453-7467 pubmed publisher
    ..glucose (PLGA-Glc) polymer-based nanoparticles (NPs) were fabricated for tumor-targeted delivery of docetaxel (DCT)...
  91. Cheng L, Ding Y, Duan X, Wu Z. Ocular pulse amplitude in different types of glaucoma using dynamic contour tonometry: Diagnosis and follow-up of glaucoma. Exp Ther Med. 2017;14:4148-4152 pubmed publisher
    ..the ocular pulse amplitude (OPA) in patients with different types of glaucoma using dynamic contour tonometry (DCT), to evaluate ocular and systemic factors associated with the OPA and to verify whether OPA measured by DCT is an ..
  92. Yokoyama K, Yasumoto K, Suzuki H, Shibahara S. Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression. J Biol Chem. 1994;269:27080-7 pubmed
    ..Both regulatory regions contain a CANNTG motif, a well known binding site for a large family of transcription factors possessing a basic helix-loop-helix structure. ..