DCT

Summary

Gene Symbol: DCT
Description: dopachrome tautomerase
Alias: TRP-2, TYRP2, L-dopachrome tautomerase, L-dopachrome Delta-isomerase, L-dopachrome isomerase, TRP2, dopachrome delta-isomerase, dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), tyrosinase related protein-2, tyrosine-related protein 2
Species: human
Products:     DCT

Top Publications

  1. Jackson I, Chambers D, Tsukamoto K, Copeland N, Gilbert D, Jenkins N, et al. A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus. EMBO J. 1992;11:527-35 pubmed
    ..Extracts from mice homozygous for the slaty mutation have a 3-fold or more reduction in DT activity, indicating that TRP-2/DT is encoded at the slaty locus, and the missense mutation reduces but does not abolish the enzyme activity. ..
  2. Yokoyama K, Suzuki H, Yasumoto K, Tomita Y, Shibahara S. Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. Biochim Biophys Acta. 1994;1217:317-21 pubmed
    ..Human TRP-2/DOPAchrome tautomerase is composed of 519 amino acids with a molecular weight of 59,000 and has about 84% identity with the mouse counterpart. ..
  3. Alonso S, Izagirre N, Smith Zubiaga I, Gardeazabal J, Díaz Ramón J, Diaz Perez J, et al. Complex signatures of selection for the melanogenic loci TYR, TYRP1 and DCT in humans. BMC Evol Biol. 2008;8:74 pubmed publisher
    ..TYR, TYRP1 and DCT were among the five most differently expressed genes between these two groups...
  4. Bouchard B, del Marmol V, Jackson I, Cherif D, Dubertret L. Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. Eur J Biochem. 1994;219:127-34 pubmed
    ..b>TYRP2 has been mapped to the chromosomal region 13q32, thus extending a region of synteny with mouse-chromosome 14.
  5. Sturm R, O Sullivan B, Box N, Smith A, Smit S, Puttick E, et al. Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. Genomics. 1995;29:24-34 pubmed
    The structures of the human tyrosinase-related protein genes TYRP1 and TYRP2 have been determined and compared with that of the tyrosinase gene (TYR). The TYRP1 protein is encoded in 7 exons spread over 24 kb of genomic DNA...
  6. Wang R, Appella E, Kawakami Y, Kang X, Rosenberg S. Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J Exp Med. 1996;184:2207-16 pubmed
    ..Like other melamona differentiation antigens, TRP-2 was only expressed in melanoma, melanocytes, and retina, but not in other human tissues tested. ..
  7. Michard Q, Commo S, Rocchetti J, El Houari F, Alleaume A, Wakamatsu K, et al. TRP-2 expression protects HEK cells from dopamine- and hydroquinone-induced toxicity. Free Radic Biol Med. 2008;45:1002-10 pubmed publisher
    We previously reported that melanogenic enzyme TRP-2 (or DCT for DOPAchrome tautomerase) expression in WM35 melanoma cells resulted in increased intracellular GSH levels, reduction in DNA damage induced by free radicals, and decreased ..
  8. Tobin D, Quinn A, Ito S, Thody A. The presence of tyrosinase and related proteins in human epidermis and their relationship to melanin type. Pigment Cell Res. 1994;7:204-9 pubmed
    ....
  9. Koumangoye R, Delpire E. DNPEP is not the only peptidase that produces SPAK fragments in kidney. Physiol Rep. 2017;5: pubmed publisher
    ..This kinase phosphorylates and activates the apical Na-Cl cotransporter in the DCT. Western blot analysis reveals that SPAK in kidney exists as a full-length protein as well as shorter fragments ..
  10. Saenz Frances F, Sanz Pozo C, Borrego Sanz L, Jañez L, Morales Fernandez L, Martínez de la Casa J, et al. Dependence of dynamic contour and Goldmann applanation tonometries on peripheral corneal thickness. Int J Ophthalmol. 2017;10:1521-1527 pubmed publisher
    To determine the effects of peripheral corneal thickness (PCT) on dynamic contour tonometry(DCT) and Goldmann applanation tonometry (GAT).

Detail Information

Publications62

  1. Jackson I, Chambers D, Tsukamoto K, Copeland N, Gilbert D, Jenkins N, et al. A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus. EMBO J. 1992;11:527-35 pubmed
    ..Extracts from mice homozygous for the slaty mutation have a 3-fold or more reduction in DT activity, indicating that TRP-2/DT is encoded at the slaty locus, and the missense mutation reduces but does not abolish the enzyme activity. ..
  2. Yokoyama K, Suzuki H, Yasumoto K, Tomita Y, Shibahara S. Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. Biochim Biophys Acta. 1994;1217:317-21 pubmed
    ..Human TRP-2/DOPAchrome tautomerase is composed of 519 amino acids with a molecular weight of 59,000 and has about 84% identity with the mouse counterpart. ..
  3. Alonso S, Izagirre N, Smith Zubiaga I, Gardeazabal J, Díaz Ramón J, Diaz Perez J, et al. Complex signatures of selection for the melanogenic loci TYR, TYRP1 and DCT in humans. BMC Evol Biol. 2008;8:74 pubmed publisher
    ..TYR, TYRP1 and DCT were among the five most differently expressed genes between these two groups...
  4. Bouchard B, del Marmol V, Jackson I, Cherif D, Dubertret L. Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. Eur J Biochem. 1994;219:127-34 pubmed
    ..b>TYRP2 has been mapped to the chromosomal region 13q32, thus extending a region of synteny with mouse-chromosome 14.
  5. Sturm R, O Sullivan B, Box N, Smith A, Smit S, Puttick E, et al. Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. Genomics. 1995;29:24-34 pubmed
    The structures of the human tyrosinase-related protein genes TYRP1 and TYRP2 have been determined and compared with that of the tyrosinase gene (TYR). The TYRP1 protein is encoded in 7 exons spread over 24 kb of genomic DNA...
  6. Wang R, Appella E, Kawakami Y, Kang X, Rosenberg S. Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J Exp Med. 1996;184:2207-16 pubmed
    ..Like other melamona differentiation antigens, TRP-2 was only expressed in melanoma, melanocytes, and retina, but not in other human tissues tested. ..
  7. Michard Q, Commo S, Rocchetti J, El Houari F, Alleaume A, Wakamatsu K, et al. TRP-2 expression protects HEK cells from dopamine- and hydroquinone-induced toxicity. Free Radic Biol Med. 2008;45:1002-10 pubmed publisher
    We previously reported that melanogenic enzyme TRP-2 (or DCT for DOPAchrome tautomerase) expression in WM35 melanoma cells resulted in increased intracellular GSH levels, reduction in DNA damage induced by free radicals, and decreased ..
  8. Tobin D, Quinn A, Ito S, Thody A. The presence of tyrosinase and related proteins in human epidermis and their relationship to melanin type. Pigment Cell Res. 1994;7:204-9 pubmed
    ....
  9. Koumangoye R, Delpire E. DNPEP is not the only peptidase that produces SPAK fragments in kidney. Physiol Rep. 2017;5: pubmed publisher
    ..This kinase phosphorylates and activates the apical Na-Cl cotransporter in the DCT. Western blot analysis reveals that SPAK in kidney exists as a full-length protein as well as shorter fragments ..
  10. Saenz Frances F, Sanz Pozo C, Borrego Sanz L, Jañez L, Morales Fernandez L, Martínez de la Casa J, et al. Dependence of dynamic contour and Goldmann applanation tonometries on peripheral corneal thickness. Int J Ophthalmol. 2017;10:1521-1527 pubmed publisher
    To determine the effects of peripheral corneal thickness (PCT) on dynamic contour tonometry(DCT) and Goldmann applanation tonometry (GAT).
  11. Gullbrand S, Schaer T, Agarwal P, Bendigo J, Dodge G, Chen W, et al. Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model. Acta Biomater. 2017;60:201-209 pubmed publisher
    ..feasibility of a triple interpenetrating network hydrogel composed of dextran, chitosan, and teleostean (DCT) for augmentation of the degenerative NP in a preclinical goat model...
  12. Michard Q, Commo S, Belaidi J, Alleaume A, Michelet J, Daronnat E, et al. TRP-2 specifically decreases WM35 cell sensitivity to oxidative stress. Free Radic Biol Med. 2008;44:1023-31 pubmed publisher
    ..Nevertheless, these properties appeared to depend on a particular cell environment because expression of TRP-2 failed to rescue HEK epithelial cells exposed to similar treatments. ..
  13. Takeda K, Yokoyama S, Yasumoto K, Saito H, Udono T, Takahashi K, et al. OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium. Biochem Biophys Res Commun. 2003;300:908-14 pubmed
    ..These RPE cells express DOPAchrome tautomerase (DCT) that is an enzyme involved in melanin biosynthesis...
  14. Boyd Shiwarski C, Shiwarski D, Roy A, Nkashama L, Namboodiri H, Xie J, et al. Potassium-Regulated Distal Tubule WNK Bodies are Kidney-Specific WNK1 Dependent. Mol Biol Cell. 2017;: pubmed publisher
    ..In the distal convoluted tubule (DCT), potassium imbalance causes WNK signaling complexes to concentrate into large discrete foci, which we call "WNK ..
  15. Oncel B, Dinc U, Orge F, Yalvac B. Comparison of IOP measurement by ocular response analyzer, dynamic contour, Goldmann applanation, and noncontact tonometry. Eur J Ophthalmol. 2009;19:936-41 pubmed
    To assess the agreement among ocular response analyzer (ORA), dynamic contour tonometry (DCT), Goldmann applanation tonometry (GAT), and noncontact tonometry (NCT), and to determine the effects of central corneal thickness (CCT) and ..
  16. Brock S, Rendon B, Yaddanapudi K, Mitchell R. Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas. J Biol Chem. 2012;287:37917-25 pubmed publisher
    ..Combined, these studies indicate that MIF and d-DT cooperate to inhibit AMPK activation in an LKB1-independent manner. ..
  17. Sturm R, Baker E, Sutherland G. Assignment of the tyrosinase-related protein-2 gene (TYRP2) to human chromosome 13q31-q32 by fluorescence in situ hybridization: extended synteny with mouse chromosome 14. Genomics. 1994;21:293-6 pubmed
  18. Adams S, Lowes M, O Neill D, Schachterle S, Romero P, Bhardwaj N. Lack of functionally active Melan-A(26-35)-specific T cells in the blood of HLA-A2+ vitiligo patients. J Invest Dermatol. 2008;128:1977-80 pubmed publisher
    ....
  19. Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, et al. Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice. Biochem Biophys Res Commun. 2017;487:368-374 pubmed publisher
    ..leading to abnormal over-activation of the WNK-OSR1/SPAK-NCC cascade in the kidney's distal convoluted tubules (DCT). KLHL2, which is highly homologous to KLHL3, was reported to ubiquitinate and degrade WNKs in vitro...
  20. Kittikulsuth W, Friedman P, Van Hoek A, Gao Y, Kohan D. Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells. BMC Nephrol. 2017;18:292 pubmed publisher
    The distal convoluted tubule (DCT) is an important nephron site for parathyroid hormone (PTH) and calcitonin regulation of urinary divalent cation excretion...
  21. Jiao Z, Zhang Z, Hornyak T, Hozeska A, Zhang R, Wang Y, et al. Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferation. Dev Biol. 2006;296:396-408 pubmed
    DOPAchrome tautomerase (Dct) functions downstream of tyrosinase in the biosynthetic pathway of eumelanin by catalyzing the conversion of dopachrome to 5,5-dihydroxyindole-2-carboxylic acid (DHICA) in pigment cells...
  22. Liu G, Khong H, Wheeler C, Yu J, Black K, Ying H. Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target in patients with malignant glioma. J Immunother. 2003;26:301-12 pubmed
    ..The authors' studies demonstrate that TRP-2 could be a useful antigen target for monitoring or developing immunotherapeutic strategies for glioma patients. ..
  23. Bonghun Shin -, Soo Jeon -, Jeongwon Ryu -, Hyock Ju Kwon -. Application of compressive sensing to portable ultrasound elastography. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:2992-2995 pubmed publisher
    ..of various CS frameworks associated with three common model bases (Fourier transform, discrete cosine transform (DCT), and wave atom (WA)) and two reconstruction algorithms (ℓ1 minimization and block sparse Bayesian ..
  24. Virador V, Matsunaga N, Matsunaga J, Valencia J, Oldham R, Kameyama K, et al. Production of melanocyte-specific antibodies to human melanosomal proteins: expression patterns in normal human skin and in cutaneous pigmented lesions. Pigment Cell Res. 2001;14:289-97 pubmed
    ..the human melanocyte-specific markers, tyrosinase, tyrosinase-related protein (TYRP1), Dopachrome tautomerase (DCT) and Pmel17 (SILV, also known as GP100)...
  25. Pisarra P, Lupetti R, Palumbo A, Napolitano A, Prota G, Parmiani G, et al. Human melanocytes and melanomas express novel mRNA isoforms of the tyrosinase-related protein-2/DOPAchrome tautomerase gene: molecular and functional characterization. J Invest Dermatol. 2000;115:48-56 pubmed
    ..The pattern of expression of these isoforms suggest that they might play a part in the normal pathway of melanin biosynthesis. ..
  26. Bernd A, Ramirez Bosca A, Kippenberger S, Martinez Liarte J, Holzmann H, Solano F. Levels of dopachrome tautomerase in human melanocytes cultured in vitro. Melanoma Res. 1994;4:287-91 pubmed
    Several reports have been published about the level of activity and possible functions of dopachrome tautomerase (DCT) in mouse melanoma cells...
  27. Zhang Z, Lei M, Xin H, Hu C, Yang T, Xing Y, et al. Wnt/β-catenin signaling promotes aging-associated hair graying in mice. Oncotarget. 2017;8:69316-69327 pubmed publisher
    ..Here, by using immunostaining and LacZ staining in Dct-LacZ mice, we show that β-catenin is expressed in melanocytes during hair cycling...
  28. Wasserman B, Carvajal Hausdorf D, Ho K, Wong W, Wu N, Chu V, et al. High concordance of a closed-system, RT-qPCR breast cancer assay for HER2 mRNA, compared to clinically determined immunohistochemistry, fluorescence in situ hybridization, and quantitative immunofluorescence. Lab Invest. 2017;97:1521-1526 pubmed publisher
    ..25% (sensitivity=0.87; specificity=0.94; PPV=0.89; NPV=0.92) using a pre-defined delta Ct cut-off (dCt≥-1) for HER2. Concordance (OPA) between RT-qPCR and QIF was 94% (sensitivity=0.90; specificity=0.96; PPV=0...
  29. Lai X, Wichers H, Soler Lopez M, Dijkstra B. Structure and Function of Human Tyrosinase and Tyrosinase-related Proteins. Chemistry. 2017;: pubmed publisher
    ..biosynthesis requires three melanogenic enzymes, tyrosinase (TYR), and the tyrosinase-related proteins TYRP1 and TYRP2. The difficulty of isolating pure and homogeneous proteins from endogenous sources has hampered their study, and ..
  30. Oh T, Lee Y, Lim B, Lim J. Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression. Int J Mol Sci. 2017;18: pubmed publisher
    ..synthesis through the suppression of melanogenesis-stimulating genes such as those encoding dopachrome tautomerase (DCT) and tyrosinase in B16F10 melanoma cells...
  31. Park J, Cho H, Kim D. Poly((D,L)lactic-glycolic)acid-star glucose nanoparticles for glucose transporter and hypoglycemia-mediated tumor targeting. Int J Nanomedicine. 2017;12:7453-7467 pubmed publisher
    ..glucose (PLGA-Glc) polymer-based nanoparticles (NPs) were fabricated for tumor-targeted delivery of docetaxel (DCT)...
  32. Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J. Crystallization and preliminary X-ray analysis of human D-dopachrome tautomerase. J Struct Biol. 1997;120:105-8 pubmed
    ..6 A resolution using a synchrotron radiation source. Crystallization of the selenomethionyl derivative of the protein for applying the multiwavelength anomalous diffraction method was also successful. ..
  33. Cheng L, Ding Y, Duan X, Wu Z. Ocular pulse amplitude in different types of glaucoma using dynamic contour tonometry: Diagnosis and follow-up of glaucoma. Exp Ther Med. 2017;14:4148-4152 pubmed publisher
    ..the ocular pulse amplitude (OPA) in patients with different types of glaucoma using dynamic contour tonometry (DCT), to evaluate ocular and systemic factors associated with the OPA and to verify whether OPA measured by DCT is an ..
  34. Aksoy P, Meneses P. The Role of DCT in HPV16 Infection of HaCaTs. PLoS ONE. 2017;12:e0170158 pubmed publisher
    ..Dopachrome tautomerase (DCT) was identified as a cellular gene required for HPV infection in HeLa cells on a siRNA screen study...
  35. Bam M, Bagchi T. Absence of tyrosinase-related protein-2/dopachrome tautomerase transcripts in PBMCs from vitiligo patients. Scand J Immunol. 2009;69:366-73 pubmed publisher
    ..Thus, we conclude that the antigen presenting cells (APC) are not in an activated state and that constitutively activated APC are possibly not required for the progression of the disease once it has been initiated. ..
  36. Lupetti R, Pisarra P, Verrecchia A, Farina C, Nicolini G, Anichini A, et al. Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. J Exp Med. 1998;188:1005-16 pubmed
    ....
  37. Huang Y, Lee T, Chan K, Hsu F, Wu Y, Lee M. Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes. J Dermatol Sci. 2008;49:115-23 pubmed
    Melanin is the pigment responsible for skin color. Melanin synthesis occurs with the participation of the tyrosinase (TYR) family of proteins including TYR, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2(TRP2/DCT).
  38. Horie Y, Takemoto Y, Miyazaki A, Namba K, Kase S, Yoshida K, et al. Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. Mol Vis. 2006;12:1601-5 pubmed
    The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT)).
  39. Loffing J, Loffing Cueni D, Valderrabano V, Kläusli L, Hebert S, Rossier B, et al. Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am J Physiol Renal Physiol. 2001;281:F1021-7 pubmed
    ..The thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC) characterized the distal convoluted tubule (DCT)...
  40. Sendoel A, Kohler I, Fellmann C, Lowe S, Hengartner M. HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature. 2010;465:577-83 pubmed publisher
    ..Knock down of the TYR-2 homologue TRP2 (also called DCT) in human melanoma cells similarly increases apoptosis, indicating an evolutionarily conserved ..
  41. Sanz García J, Maschietto F, Campetella M, Ciofini I. Using Density Based Indexes and Wavefunction Methods for the Description of Excited States: Excited State Proton Transfer Reactions as Test Case. J Phys Chem A. 2017;: pubmed publisher
    ..to interpret photochemical reactions, in this paper we demonstrate how a recently developed density-based index (DCT), up to now used in conjunction with Time Dependent Density Functional Theory methods, can be extended to multi-..
  42. Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J. Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. Biochemistry. 1999;38:3268-79 pubmed
    ..The present structural study could be helpful for designing effective inhibitors that modulate immunoregulatory and hormone-like effects. ..
  43. Jensen B, Stubbe J, Hansen P, Andreasen D, Skøtt O. Localization of prostaglandin E(2) EP2 and EP4 receptors in the rat kidney. Am J Physiol Renal Physiol. 2001;280:F1001-9 pubmed
    ..The EP4 receptor was expressed in distal convoluted tubule (DCT) and cortical collecting duct (CCD) in preglomerular vessels, and in outer medullary vasa recta...
  44. Yokoyama K, Yasumoto K, Suzuki H, Shibahara S. Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression. J Biol Chem. 1994;269:27080-7 pubmed
    ..Both regulatory regions contain a CANNTG motif, a well known binding site for a large family of transcription factors possessing a basic helix-loop-helix structure. ..
  45. Joshi S, Tandukar B, Castaneda M, Jiang S, Diwakar G, Hertzano R, et al. Characterization of a new, inducible transgenic mouse model with GFP expression in melanocytes and their precursors. Gene Expr Patterns. 2017;27:76-84 pubmed publisher
    Melanocytes are neural crest-derived cells that are responsible for mammalian hair follicle (HF) pigmentation. The Dct-LacZ transgenic mouse is extensively used to study melanocyte biology but lacks conditionally-inducible labelling and ..
  46. Khong H, Rosenberg S. Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy. J Immunol. 2002;168:951-6 pubmed
    ....
  47. Suzuki I, Kato T, Motokawa T, Tomita Y, Nakamura E, Katagiri T. Increase of pro-opiomelanocortin mRNA prior to tyrosinase, tyrosinase-related protein 1, dopachrome tautomerase, Pmel-17/gp100, and P-protein mRNA in human skin after ultraviolet B irradiation. J Invest Dermatol. 2002;118:73-8 pubmed
    ....
  48. Sales Sanz M, Arranz Marquez E, Arruabarrena C, Teus M. Influence of LASEK on Schiøtz, Goldmann and dynamic contour Tonometry. Graefes Arch Clin Exp Ophthalmol. 2018;256:173-179 pubmed publisher
    ..with Goldmann applanation tonometry (GAT), Schiøtz indentation tonometry (ST) and dynamic contour tonometry (DCT). Prospective, observational, single-masked cohort study...
  49. Maggu J, Singh P, Majumdar A. Multi-echo reconstruction from partial K-space scans via adaptively learnt basis. Magn Reson Imaging. 2017;45:105-112 pubmed publisher
    ..has been observed in several areas of traditional compressed sensing, that instead of using fixed basis (wavelet, DCT etc.), considerably better results can be achieved by learning the basis adaptively from the data...
  50. Ohyama K, Suzuki K. Dihydrocapsiate improved age-associated impairments in mice by increasing energy expenditure. Am J Physiol Endocrinol Metab. 2017;313:E586-E597 pubmed publisher
    ..Dihydrocapsiate (DCT) is a compound that belongs to the capsinoid family...
  51. Orlow S, Zhou B, Chakraborty A, Drucker M, Pifko Hirst S, Pawelek J. High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex. J Invest Dermatol. 1994;103:196-201 pubmed
    ....
  52. Zhang Y, Liu J, Peng L, Ren L, Zhang H, Zou L, et al. Comparative transcriptome analysis of molecular mechanism underlying gray-to-red body color formation in red crucian carp (Carassius auratus, red var.). Fish Physiol Biochem. 2017;: pubmed publisher
    ..synthesis, such as the melanogenesis genes (Mitfa, Pax3a, Foxd3, Mc1r, Asip); tyrosine metabolism genes (Tyr, Dct, Tyrp1, Silva, Tat, Hpda); and pteridine metabolism genes (Gch, Xdh, Ptps, Tc)...
  53. Cassady J, Sturm R. Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA. Gene. 1994;143:295-8 pubmed
    ..Northern blot analysis reveals that TRP-2 is expressed at high levels in human melanoma cells. ..
  54. Ishizuka A, Oka M, Seki T, Shibata N, Ishizuka K. Boundary-artifact-free determination of potential distribution from differential phase contrast signals. Microscopy (Oxf). 2017;:1-9 pubmed publisher
    ..Specifically, we demonstrate that the discrete cosine transform (DCT) is the method to solve the Poisson equation, since we can use the Neumann boundary condition directly specified by ..
  55. West C, Welling P, West D, Coleman R, Cheng K, Chen C, et al. Renal and colonic potassium transporters in the pregnant rat. Am J Physiol Renal Physiol. 2017;:ajprenal.00288.2017 pubmed publisher
    ..apical ROMK abundance (by immunofluorescence) was decreased in pregnant vs virgin in the distal convoluted tubule (DCT) and connecting tubule (CNT)...
  56. Galindo Ferreiro A, Dufaileej M, Gálvez Ruiz A, Khandekar R, Schellini S. Dacryocystectomy: Indications and Results at Tertiary Eye Hospital in Central Saudi Arabia. Semin Ophthalmol. 2017;:1-4 pubmed publisher
    To report indications and success rates of dacryocystectomy (DCT) in a tertiary hospital.
  57. Chi D, Merchant R, Rand R, Conrad A, Garrison D, Turner R, et al. Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas. Am J Pathol. 1997;150:2143-52 pubmed
    ..These studies demonstrate that melanomas and primary brain tumors express common MAAs and could be exploited in patients with malignant glioma by active specific immunotherapy against these common MAAs. ..
  58. Tu D, Gao X, Wang D, Cai Y. A New Measurement of Internet Addiction Using Diagnostic Classification Models. Front Psychol. 2017;8:1768 pubmed publisher
    ..from the questionnaires for internet addiction, a diagnostic classification test for internet addiction (the DCT-IA) was developed using diagnostic classification models (DCMs), a cutting-edge psychometric theory, based on DSM-5...
  59. Slutzkey S, Moses O, Tal H, Meirowitz A, Matalon S. Direct Contact Test for Evaluating Bacterial Growth on Machined and Rough Surface Implants: An In Vitro Study. Implant Dent. 2017;: pubmed publisher
    To use a modified direct contact test (DCT) to evaluate the bacterial growth on 3 commercially available implants.
  60. Odh G, Hindemith A, Rosengren A, Rosengren E, Rorsman H. Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole. Biochem Biophys Res Commun. 1993;197:619-24 pubmed
    ..The molecular weight of D-dopachrome tautomerase monomer was approximately 12 kD and its N-terminal amino acid sequence was P-F-V-E-L-E-T-N-L-P-A-. The Km for D-dopachrome was 1.5 mM and Vmax 0.5 mmol per min and mg protein. ..
  61. Song H, Wu Z, Fei Q, Yan J, Liu Z, Zhang J, et al. [Association study of Trp2 allele polymorphism with degenerative disc disease in a Chinese Han nationality]. Zhonghua Yi Xue Za Zhi. 2010;90:148-52 pubmed
    To investigate the association between Trp2 allele polymorphism with degenerative disc disease (DDD) in a Chinese Han population. A total of 125 DDD patients (58 males and 67 females, 51.8 +/- 7...
  62. Kippenberger S, Loitsch S, Solano F, Bernd A, Kaufmann R. Quantification of tyrosinase, TRP-1, and Trp-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormones. J Invest Dermatol. 1998;110:364-7 pubmed
    ..We therefore suggest that hyperpigmentation during pregnancy or under contraceptive treatment is mediated by a direct induction of melanogenesis via sex steroids. ..