DCD

Summary

Gene Symbol: DCD
Description: dermcidin
Alias: AIDD, DCD-1, DSEP, HCAP, PIF, dermcidin, diffusible survival/evasion peptide, preproteolysin, proteolysis inducing factor, survival promoting peptide
Species: human
Products:     DCD

Top Publications

  1. Todorov P, Deacon M, Tisdale M. Structural analysis of a tumor-produced sulfated glycoprotein capable of initiating muscle protein degradation. J Biol Chem. 1997;272:12279-88 pubmed
    ..Neither chain was cleaved into disaccharides with chondroitinase ABC, suggesting that the material is a sulfated glycoprotein. ..
  2. Lowrie A, Wigmore S, Wright D, Waddell I, Ross J. Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues. Br J Cancer. 2006;94:1663-71 pubmed
    ..peptide with homology to the unglycosylated neuronal survival peptide Y-P30 and a predicted product of the dermcidin gene, a pro-survival oncogene in breast cancer...
  3. Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S, et al. Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nat Immunol. 2001;2:1133-7 pubmed
    ..Here we describe the isolation of the gene Dermcidin, which encodes an antimicrobial peptide that has a broad spectrum of activity and no homology to other known ..
  4. Stewart G, Lowrie A, Riddick A, Fearon K, Habib F, Ross J. Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia. Prostate. 2007;67:1308-17 pubmed
    b>Dermcidin (DCD) is a candidate survival gene in breast cancer. DCD gene expression has been identified in prostate cancer cell lines and primary prostate cancer tissue...
  5. Zeggini E, Scott L, Saxena R, Voight B, Marchini J, Hu T, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40:638-45 pubmed publisher
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D. ..
  6. Landgraf P, Wahle P, Pape H, Gundelfinger E, Kreutz M. The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity. J Biol Chem. 2008;283:25036-45 pubmed publisher
    ..This identifies a new mechanism of communication between the nervous and the immune system that might directly affect the wiring of the brain during development. ..
  7. Baechle D, Flad T, Cansier A, Steffen H, Schittek B, Tolson J, et al. Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L. J Biol Chem. 2006;281:5406-15 pubmed
    ..To identify potential substrates of CatD in human eccrine sweat LL-37 and DCD-1L, two antimicrobial peptides present in sweat, were digested in vitro with purified CatD...
  8. Lee Motoyama J, Kim Motoyama H, Kim P, Nakagama H, Miyagawa K, Suzuki K. Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. Biochem Biophys Res Commun. 2007;357:828-33 pubmed
    b>Dermcidin (DCD) is a gene for an antimicrobial peptide DCD-1 in human sweat glands. It has become evident that the gene products of DCD exhibit a wide range of biological functions...
  9. Song C, Weichbrodt C, Salnikov E, Dynowski M, Forsberg B, Bechinger B, et al. Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proc Natl Acad Sci U S A. 2013;110:4586-91 pubmed publisher
    ..X-ray crystal structure as well as solid-state NMR spectroscopy, electrophysiology, and MD simulations of human dermcidin in membranes that reveal the antibiotic mechanism of this major human antimicrobial, found to suppress ..

More Information

Publications112 found, 100 shown here

  1. Todorov P, Cariuk P, McDevitt T, Coles B, Fearon K, Tisdale M. Characterization of a cancer cachectic factor. Nature. 1996;379:739-42 pubmed
    ..This suggests that cachexia in mice and humans may be produced by the same material. ..
  2. Cunningham T, Hodge L, Speicher D, Reim D, Tyler Polsz C, Levitt P, et al. Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin. J Neurosci. 1998;18:7047-60 pubmed
    ..The phosphatase activity of this molecule also suggests the potential for direct neuron survival-promoting effects. ..
  3. Cunningham T, Jing H, Wang Y, Hodge L. Calreticulin binding and other biological activities of survival peptide Y-P30 including effects of systemic treatment of rats. Exp Neurol. 2000;163:457-68 pubmed
    ..The results also suggest that some of these activities are apparent in the cerebral cortex after systemic application of this peptide. ..
  4. Cunningham T, Jing H, Akerblom I, Morgan R, Fisher T, Neveu M. Identification of the human cDNA for new survival/evasion peptide (DSEP): studies in vitro and in vivo of overexpression by neural cells. Exp Neurol. 2002;177:32-9 pubmed
    ..The peptide is called DSEP (dee-sep) for diffusible survival evasion peptide. Part of the survival advantage of DSEP overexpressors may be due to their attenuated response to ..
  5. Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti Domenici J, et al. A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A. 2003;100:10931-6 pubmed
    ..The transcript corresponding to this SAGE tag, dermcidin (DCD), encodes a secreted protein normally expressed only in the pons of the brain and sweat glands...
  6. Monitto C, Dong S, Jen J, Sidransky D. Characterization of a human homologue of proteolysis-inducing factor and its role in cancer cachexia. Clin Cancer Res. 2004;10:5862-9 pubmed
  7. Stewart G, Skipworth R, Pennington C, Lowrie A, Deans D, Edwards D, et al. Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines. Br J Cancer. 2008;99:126-32 pubmed publisher
    b>Dermcidin acts as a survival factor in a variety of cancer cell lines under hypoxia or oxidative stress...
  8. Staiger H, Machicao F, Kantartzis K, Schäfer S, Kirchhoff K, Guthoff M, et al. Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes. PLoS ONE. 2008;3:e3019 pubmed publisher
    ..rs864745, CDC123/CAMK1D rs12779790, TSPAN8/LGR5 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs10923931, DCD rs1153188, VEGFA rs9472138, and BCL11A rs10490072...
  9. Meigs J, Shrader P, Sullivan L, McAteer J, Fox C, Dupuis J, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med. 2008;359:2208-19 pubmed publisher
    ..A genotype score based on 18 risk alleles predicted new cases of diabetes in the community but provided only a slightly better prediction of risk than knowledge of common risk factors alone. ..
  10. Stewart G, Skipworth R, Ross J, Fearon K, Baracos V. The dermcidin gene in cancer: role in cachexia, carcinogenesis and tumour cell survival. Curr Opin Clin Nutr Metab Care. 2008;11:208-13 pubmed publisher
    The diverse protein products of the dermcidin gene are relevant to immunity, cancer cell progression and cancer cachexia. This article evaluates recent developments/controversies around dermcidin...
  11. Pathak S, de Souza G, Salte T, Wiker H, Asjo B. HIV induces both a down-regulation of IRAK-4 that impairs TLR signalling and an up-regulation of the antibiotic peptide dermcidin in monocytic cells. Scand J Immunol. 2009;70:264-76 pubmed publisher
    ..is essential for virtually all TLR signalling, was suppressed, whereas the precursor for the antibiotic peptide Dermcidin was up-regulated in HIV-infected cells...
  12. Ghosh R, Karmohapatra S, Bhattacharyya M, Bhattacharya R, Bhattacharya G, Sinha A. The appearance of dermcidin isoform 2, a novel platelet aggregating agent in the circulation in acute myocardial infarction that inhibits insulin synthesis and the restoration by acetyl salicylic acid of its effects. J Thromb Thrombolysis. 2011;31:13-21 pubmed publisher
    ..b>Dermcidin isoform 2 (dermcidin) was determined by enzyme linked immunosorbent assay...
  13. Grabiec K, Burchert M, Milewska M, BÅ‚aszczyk M, Grzelkowska Kowalczyk K. [Systemic and local mechanisms leading to cachexia in cancer]. Postepy Hig Med Dosw (Online). 2013;67:1397-409 pubmed publisher
    ..The main mediators of skeletal muscle wasting in cancer are proteolysis-inducing factor (PIF), proinflammatory cytokines, and angiotensin II acting through increased levels of reactive oxygen species (ROS) ..
  14. Zeng C, Hu X, He W, Wang Y, Li L, Xiong Y, et al. Hypothermic machine perfusion ameliorates inflammation during ischemia?reperfusion injury via sirtuin?1?mediated deacetylation of nuclear factor??B p65 in rat livers donated after circulatory death. Mol Med Rep. 2017;16:8649-8656 pubmed publisher
    ..perfusion (HMP) effectively reduces ischemia?reperfusion injury (IRI) in livers donated after circulatory death (DCD) when compared with cold storage (CS). However, the underlying mechanisms remain unclear...
  15. Lan H, Su Y, Liu Y, Deng C, Wang J, Chen T, et al. Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway. Life Sci. 2019;: pubmed publisher
    ..shortage of donor hearts could be alleviated with the use of the allografts from donation after circulatory death (DCD)...
  16. Huerter M, Sharma A, Zhao Y, Charles E, Kron I, Laubach V. Attenuation of Pulmonary Ischemia-Reperfusion Injury by Adenosine A2B Receptor Antagonism. Ann Thorac Surg. 2016;102:385-393 pubmed publisher
    ..A murine model of EVLP was also used to evaluate rehabilitation of donation after circulatory death (DCD) lungs. DCD lungs underwent ischemia, cold preservation, and EVLP with Steen solution with or without ATL802...
  17. Dong Z, Shi L, Ye L, Xu Z, Zhou L. [Risk factors analysis of renal replacement therapy after liver transplantation and prognosis effect of initial treatment time]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:1056-1060 pubmed publisher
    ..Clinical data of 132 recipients undergoing organ donation for cardiac death (DCD) allograft orthotopic liver transplantation admitted to Ningbo Medical Center Lihuili Hospital and Ningbo Medical ..
  18. Saat T, Susa D, Kok N, van den Engel S, Roest H, van der Laan L, et al. Inflammatory genes in rat livers from cardiac- and brain death donors. J Surg Res. 2015;198:217-27 pubmed publisher
    ..of not only donation after brain death (DBD) donors but also living donors (LD) and donation after cardiac death (DCD) donors...
  19. Ming Hua C, Bao Hua Z, Lei Y. Mechanisms of Anorexia Cancer Cachexia Syndrome and Potential Benefits of Traditional Medicine and Natural Herbs. Curr Pharm Biotechnol. 2016;17:1147-1152 pubmed
    ..which is represented by increased plasma levels of IL-1, IL-6, TNF-alpha, tumor-induced factors, such as PIF and LMF...
  20. Ye H, Wang D, Zhang C, Zhang L, Wang H, Li Z, et al. Pathological characteristics of liver allografts from donation after brain death followed by cardiac death in pigs. J Huazhong Univ Sci Technolog Med Sci. 2014;34:687-691 pubmed publisher
    ..pigs (25-30 kg) were allocated randomly into donation after brain death (DBD), donation after circulatory death (DCD) and DBCD groups. Brain death was induced by augmenting intracranial pressure...
  21. Xue S, He W, Zeng X, Tang Z, Feng S, Zhong Z, et al. Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway. Mol Med Rep. 2018;18:815-826 pubmed publisher
    ..HMP) has been demonstrated to be a more effective method for preserving livers donated after circulatory death (DCD) than cold storage (CS); however, the underlying mechanisms remain unclear...
  22. Kawasaki S, Aoki N, Kikuchi H, Nakayama H, Saito N, Shimada H, et al. Clinical and microbiological evaluation of hemodialysis-associated pneumonia (HDAP): should HDAP be included in healthcare-associated pneumonia?. J Infect Chemother. 2011;17:640-5 pubmed publisher
    Although hemodialysis-associated pneumonia (HDAP) was included among the healthcare-associated pneumonias (HCAP) in the 2005 American Thoracic Society (ATS)/Infectious Diseases Society of America (IDSA) guideline, little information ..
  23. Khan M, Mobin M, Abbas Z, Siddiqui M. Nitric oxide-induced synthesis of hydrogen sulfide alleviates osmotic stress in wheat seedlings through sustaining antioxidant enzymes, osmolyte accumulation and cysteine homeostasis. Nitric Oxide. 2017;68:91-102 pubmed publisher
    ..the activities of H2S-synthesizing enzymes l-cysteine desulfhydrase (LCD) and d-cysteine desulfhydrase (DCD) leading to enhanced level of endogenous H2S content...
  24. Cobo E, Kissoon Singh V, Moreau F, Holani R, Chadee K. MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate-Induced Colitis. Infect Immun. 2017;85: pubmed publisher
    ..Humans and mice have one cathelicidin-related antimicrobial peptide (CRAMP) each, LL-37/hCAP-18 and Cramp, respectively, with related structure and functions...
  25. Kron P, Schlegel A, Mancina L, Clavien P, Dutkowski P. Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans. J Hepatol. 2017;: pubmed publisher
    ..Protection of human donation after cardiac death (DCD) livers by a novel machine perfusion technique, hypothermic oxygenated perfusion (HOPE), was recently established...
  26. Schulze M, Weikert C, Pischon T, Bergmann M, Al Hasani H, Schleicher E, et al. Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study. Diabetes Care. 2009;32:2116-9 pubmed publisher
    ..002). Twenty SNPs did not improve discrimination beyond these characteristics (P = 0.69). Metabolic markers, but not genotyping for 20 diabetogenic SNPs, improve discrimination of incident type 2 diabetes beyond lifestyle risk factors. ..
  27. Hands B, Licari M, Piek J. A review of five tests to identify motor coordination difficulties in young adults. Res Dev Disabil. 2015;41-42:40-51 pubmed publisher
    ..with low motor competence in childhood and adolescence, such as that seen in Developmental Coordination Disorder (DCD), often persist into adulthood...
  28. Caçola P, ROMERO M, Ibana M, Chuang J. Effects of two distinct group motor skill interventions in psychological and motor skills of children with Developmental Coordination Disorder: A pilot study. Disabil Health J. 2016;9:172-8 pubmed publisher
    Children with Developmental Coordination Disorder (DCD) have an increased risk for mental health difficulties...
  29. Hosgood S, Barlow A, Dormer J, Nicholson M. The use of ex-vivo normothermic perfusion for the resuscitation and assessment of human kidneys discarded because of inadequate in situ perfusion. J Transl Med. 2015;13:329 pubmed publisher
    ..Nineteen out of 22 kidneys (86 %) were from DCD donors...
  30. Hernandez Hernandez E, Fernández Medina R, Navarro Escalante L, Nuñez J, Benavides Machado P, Carareto C. Genome-wide analysis of transposable elements in the coffee berry borer Hypothenemus hampei (Coleoptera: Curculionidae): description of novel families. Mol Genet Genomics. 2017;292:565-583 pubmed publisher
    ..CR1, Daphne, I/Nimb, Jockey, Kiri, R1, R2 and R4) clades and DNA superfamilies (Tc1-mariner, hAT, Merlin, P, PIF-Harbinger, PiggyBac and Helitron)...
  31. Dong Y, Wang W, Jiang T, Xu J, Han C, Yan S, et al. Molecular and Epidemiological Characterization of Infant Botulism in Beijing, China. Biomed Environ Sci. 2017;30:460-464 pubmed publisher
    ..Mice injected with cultures generated from the enema sample and ingested Powered infant formula (PIF) presented typical signs of botulism...
  32. D Amore A, Luketich S, Raffa G, Olia S, Menallo G, Mazzola A, et al. Heart valve scaffold fabrication: Bioinspired control of macro-scale morphology, mechanics and micro-structure. Biomaterials. 2018;150:25-37 pubmed publisher
    ..This study aimed to overcome these limitations by introducing double component deposition (DCD), an electrodeposition technique that employs multi-phase electrodes to dictate valve macro and microstructure and ..
  33. Senter Zapata M, Khan A, Subramanian T, Vachharajani N, Dageforde L, Wellen J, et al. Patient and Graft Survival: Biliary Complications after Liver Transplantation. J Am Coll Surg. 2018;226:484-494 pubmed publisher
    ..Biliary complications after LT can significantly decrease patient and graft survival rates. Careful donor and recipient selection and attention to anastomotic technique can reduce BCs and improve outcomes. ..
  34. Schleinitz D, Tonjes A, Bottcher Y, Dietrich K, Enigk B, Koriath M, et al. Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits. Horm Metab Res. 2010;42:14-22 pubmed publisher
    ..We performed an association study of 9 SNPs in or around JAZF1, CDC123/ CAMK1D, NOTCH2, BCL11A, ADAMTS9, VEGFA, DCD, THADA, and TSPAN8/ LGR5 with T2D and related quantitative traits (fasting insulin and glucose, indices derived ..
  35. Lu H, Lu L, Xu Z, Lu Y, Zhao B, Zhuang L, et al. Tauroursodeoxycholic acid and 4-phenyl butyric acid alleviate endoplasmic reticulum stress and improve prognosis of donation after cardiac death liver transplantation in rats. Hepatobiliary Pancreat Dis Int. 2014;13:586-93 pubmed
    ..reticulum (ER) stress is involved in ischemia-reperfusion injury, but its role in donation after cardiac death (DCD) liver transplantation is not clear and the effect of ER stress inhibitors, tauroursodeoxycholic acid (TUDCA) and 4-..
  36. Kim J, Song K, Park E, Kim K, Bae G, Choi G. Epidermal Phytochrome B Inhibits Hypocotyl Negative Gravitropism Non-Cell-Autonomously. Plant Cell. 2016;28:2770-2785 pubmed
    ..The Arabidopsis thaliana pif quadruple mutant (pifQ), which lacks four PHYTOCHROME-INTERACTING FACTORS (PIFs), is agravitropic in the dark...
  37. Xie Y, Liu Y, Wang H, Ma X, Wang B, Wu G, et al. Phytochrome-interacting factors directly suppress MIR156 expression to enhance shade-avoidance syndrome in Arabidopsis. Nat Commun. 2017;8:348 pubmed publisher
    ..The simulated shade induces rapid accumulation of PIF proteins, reduced expression of multiple MIR156 genes, and concomitant elevated expression of the SQUAMOSA-PROMOTER ..
  38. Khorsandi S, Salehi S, Cortés M, Vilca Melendez H, Menon K, Srinivasan P, et al. An in silico argument for mitochondrial microRNA as a determinant of primary non function in liver transplantation. Sci Rep. 2018;8:3105 pubmed publisher
    ..with the mitochondrial proteome in a clinical model of primary non function (PNF) of the donor after cardiac death (DCD) liver...
  39. Wind J, van Mook W, Dhanani S, van Heurn E. Determination of death after circulatory arrest by intensive care physicians: A survey of current practice in the Netherlands. J Crit Care. 2016;31:2-6 pubmed publisher
    Determination of death is an essential part of donation after circulatory death (DCD)...
  40. Zhu L, Xin R, Bu Q, Shen H, Dang J, Huq E. A Negative Feedback Loop between PHYTOCHROME INTERACTING FACTORs and HECATE Proteins Fine-Tunes Photomorphogenesis in Arabidopsis. Plant Cell. 2016;28:855-74 pubmed publisher
    ..HEC1 and HEC2 heterodimerize with PIF family members...
  41. Moir J, Cameron K, Di H. Potential Pasture Nitrogen Concentrations and Uptake from Autumn or Spring Applied Cow Urine and DCD under Field Conditions. Plants (Basel). 2016;5: pubmed publisher
    ..autumn and spring deposition of cow urine and the effects of fine particle suspension (FPS) dicyandiamide (DCD)...
  42. Moynihan M, Peterson K, Cantoral A, Song P, Jones A, Solano González M, et al. Dietary predictors of urinary cadmium among pregnant women and children. Sci Total Environ. 2017;575:1255-1262 pubmed publisher
    ..In pregnant women and children, unique dietary habits may contribute to DCd, and the relationship of diet to overall cadmium exposure can depend on specific factors during these transitional ..
  43. Cacola P, Getchell N, Srinivasan D, Alexandrakis G, Liu H. Cortical activity in fine-motor tasks in children with Developmental Coordination Disorder: A preliminary fNIRS study. Int J Dev Neurosci. 2018;65:83-90 pubmed publisher
    Developmental Coordination Disorder (DCD) is as a neurodevelopmental condition characterized by poor motor proficiency, which impacts academic performance and activities of daily living...
  44. Faitot F, Besch C, Battini S, Ruhland E, Onea M, Addeo P, et al. Impact of real-time metabolomics in liver transplantation: Graft evaluation and donor-recipient matching. J Hepatol. 2018;68:699-706 pubmed publisher
    ..of liver allografts especially in the novel setting of machine perfusion preservation and donor in cardiac death (DCD) grafts...
  45. Mueller M, Schoeberlein A, Zhou J, Joerger Messerli M, Oppliger B, Reinhart U, et al. PreImplantation Factor bolsters neuroprotection via modulating Protein Kinase A and Protein Kinase C signaling. Cell Death Differ. 2015;22:2078-86 pubmed publisher
    A synthetic peptide (sPIF) analogous to the mammalian embryo-derived PreImplantation Factor (PIF) enables neuroprotection in rodent models of experimental autoimmune encephalomyelitis and perinatal brain injury...
  46. Goulardins J, Rigoli D, Licari M, Piek J, Hasue R, Oosterlaan J, et al. Attention deficit hyperactivity disorder and developmental coordination disorder: Two separate disorders or do they share a common etiology. Behav Brain Res. 2015;292:484-92 pubmed publisher
    ..Developmental coordination disorder (DCD) is one of the most prevalent childhood movement disorders...
  47. Artero A, Atienza A, Correa S, López I, Faus A, Puchades F, et al. Ertapenem therapy for pneumonia requiring hospital admission in elderly people. Rev Esp Quimioter. 2016;29:8-14 pubmed
    ..7% had one or more comorbidities. Healthcare-associated pneumonia (HCAP) and aspiration pneumonia were significantly higher in the ertapenem group (66.7% vs. 24.0%, p < 0.001 and 73...
  48. Zhang Y, Mu Y, Zhou Y, Tian D, Liu J, Zhang C. NO and N2O emissions from agricultural fields in the North China Plain: Origination and mitigation. Sci Total Environ. 2016;551-552:197-204 pubmed publisher
    ..we comparably investigated the effects of ammonium, nitrate fertilizers and nitrification inhibitor dicyandiamide (DCD) addition on NO and N2O emissions from the agricultural soil in the North China Plain (NCP)...
  49. Soy J, Leivar P, González Schain N, Martín G, Diaz C, Sentandreu M, et al. Molecular convergence of clock and photosensory pathways through PIF3-TOC1 interaction and co-occupancy of target promoters. Proc Natl Acad Sci U S A. 2016;113:4870-5 pubmed publisher
    ..b>PIF protein abundance in SDs oscillates as a balance between synthesis and photoactivated-phytochrome-imposed ..
  50. Sharifi A, Hosseinzadeh Attar M, Vahedi H, Nedjat S. A randomized controlled trial on the effect of vitamin D3 on inflammation and cathelicidin gene expression in ulcerative colitis patients. Saudi J Gastroenterol. 2016;22:316-23 pubmed publisher
    ..To characterize the effects of Vitamin D on cathelicidin (hCAP/LL37) gene expression, ESR, and serum hs-CRP levels...
  51. Ding C, Tai Q, Han F, Li Y, Tian X, Tian P, et al. Predictive Score Model for Delayed Graft Function Based on Easily Available Variables before Kidney Donation after Cardiac Death. Chin Med J (Engl). 2017;130:2429-2434 pubmed publisher
    How to evaluate the quality of donation after cardiac death (DCD) kidneys has become a critical problem in kidney transplantation in China...
  52. Joseph B, Khalil M, Pandit V, Orouji Jokar T, Cheaito A, Kulvatunyou N, et al. Increasing organ donation after cardiac death in trauma patients. Am J Surg. 2015;210:468-72 pubmed publisher
    Organ donation after cardiac death (DCD) is not optimal but still remains a valuable source of organ donation in trauma donors. The aim of this study was to assess national trends in DCD from trauma patients...
  53. Karaboğa B, Uzun R, Çilli A. [Health-care associated pneumonia]. Tuberk Toraks. 2015;63:86-93 pubmed
    Health-care associated pneumonia (HCAP) is defined as pneumonia that develops in patients with a history of recent hospitalization, hemodialysis as an outpatient, residence in a nursing home, outpatient intravenous therapy and home wound ..
  54. Guo M, Yao D, Li L, Lu C, Li Y, Li J. Intestinal Conditioning After Cardiac Arrest: The Use of Normothermic Extracorporeal Membrane Oxygenation in the Non-Heart-Beating Animal Model. Artif Organs. 2016;40:738-45 pubmed publisher
    ..first group served as the live donation (LD) group, the second group served as the donation after cardiac death (DCD) group, and the remaining were further assigned into three subgroups: E1 group (1 h NECMO support), E3 group (3 h ..
  55. Messer S, Page A, Axell R, Berman M, Hernández Sánchez J, Colah S, et al. Outcome after heart transplantation from donation after circulatory-determined death donors. J Heart Lung Transplant. 2017;36:1311-1318 pubmed publisher
    ..Transplanting hearts after donation after circulatory-determined death (DCD) may be a viable additive alternative to DBD donors...
  56. Qiming C, Tingting T, Xiaomei B, Yingjian L, Fengxia L, Ligong Z, et al. Mining for sensitive and reliable species-specific primers for PCR for detection of Cronobacter sakazakii by a bioinformatics approach. J Dairy Sci. 2015;98:5091-101 pubmed publisher
    ..Cronobacter sakazakii were detected in artificially contaminated powdered infant formula (PIF) by PCR using primer sets CS21 and CS38 after 8h of enrichment. The detection limit was 5...
  57. Pedmale U, Huang S, Zander M, Cole B, Hetzel J, Ljung K, et al. Cryptochromes Interact Directly with PIFs to Control Plant Growth in Limiting Blue Light. Cell. 2016;164:233-245 pubmed publisher
    ..Our results indicate that CRYs signal by modulating PIF activity genome wide and that these factors integrate binding of different plant photoreceptors to facilitate ..
  58. Bieber E, Smits Engelsman B, Sgandurra G, Cioni G, Feys H, Guzzetta A, et al. Manual function outcome measures in children with developmental coordination disorder (DCD): Systematic review. Res Dev Disabil. 2016;55:114-31 pubmed publisher
    ..psychometric properties of manual function outcome measures for children with developmental coordination disorder (DCD) aged 3-18 years...
  59. Goglia A, Wilson M, DiGiorno D, Toettcher J. Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System. Methods Mol Biol. 2017;1636:3-20 pubmed publisher
  60. Horie H, Ito I, Konishi S, Yamamoto Y, Yamamoto Y, Uchida T, et al. Isolation of ESBL-producing Bacteria from Sputum in Community-acquired Pneumonia or Healthcare-associated Pneumonia Does Not Indicate the Need for Antibiotics with Activity against This Class. Intern Med. 2017;: pubmed publisher
    ..isolates. We identified patients with community-acquired pneumonia (CAP) or healthcare-associated pneumonia (HCAP) from whom ESBL-producing bacteria had been isolated from sputum culture and to whom antibiotic treatment had been ..
  61. Fei P, Jiang Y, Jiang Y, Yuan X, Yang T, Chen J, et al. Prevalence, Molecular Characterization, and Antibiotic Susceptibility of Cronobacter sakazakii Isolates from Powdered Infant Formula Collected from Chinese Retail Markets. Front Microbiol. 2017;8:2026 pubmed publisher
    ..pathogen that causes severe infections in neonates and infants through contaminated powdered infant formula (PIF)...
  62. Hannant P, Cassidy S, Van de Weyer R, Mooncey S. Sensory and motor differences in Autism Spectrum Conditions and developmental coordination disorder in children: A cross-syndrome study. Hum Mov Sci. 2018;58:108-118 pubmed publisher
    Recent research has shown that Developmental coordination disorder (DCD) can present with some similar symptomology as Autism Spectrum Conditions (ASC)...
  63. Tal Saban M, Ornoy A, Parush S. Success in Adults With Probable Developmental Coordination Disorder Using Structural Equation Modeling. Am J Occup Ther. 2018;72:7202205010p1-7202205010p8 pubmed publisher
    ..study was to conduct a broad in-depth examination of the relationship between developmental coordination disorder (DCD) and use of executive strategies, daily life activities, emotional state, and internal factors attributed to ..
  64. Mikhaylova M, Schumacher A, Borutzki C, Neumann J, Macharadze T, El Mousleh T, et al. Analysis of Y-P30/Dermcidin expression and properties of the Y-P30 peptide. BMC Res Notes. 2014;7:400 pubmed publisher
    The survival promoting peptide Y-P30 has a variety of neuritogenic and neuroprotective effects in vitro and in vivo...
  65. Wilmut K, Du W, Barnett A. Gait patterns in children with Developmental Coordination Disorder. Exp Brain Res. 2016;234:1747-55 pubmed publisher
    Previous research has shown that adults with Developmental Coordination Disorder (DCD) show increased variability of foot placement measures and movement of the centre of mass (CoM) while walking...
  66. Thangarajan R, Bolan N, Kunhikrishnan A, Wijesekara H, Xu Y, Tsang D, et al. The potential value of biochar in the mitigation of gaseous emission of nitrogen. Sci Total Environ. 2018;612:257-268 pubmed publisher
    ..This study examined the effect of biochar and a chemical nitrification inhibitor, dicyandiamide (DCD), on N transformation and N losses via gaseous emission of NH3 and N2O from agricultural ..
  67. Liu L, Lu L, Yue H, Huan B, Gu G, Jin H, et al. [Association between family environment and developmental coordination disorder in preschool children]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:989-993 pubmed
    To investigate the influence of family environment on developmental coordination disorder (DCD) in preschool children. Stratified random cluster sampling was used to select 1 727 children (4-6 years old)...
  68. Schlegel A, Kalisvaart M, Scalera I, Laing R, Mergental H, Mirza D, et al. The UK DCD Risk Score: A new proposal to define futility in donation-after-circulatory-death liver transplantation. J Hepatol. 2018;68:456-464 pubmed publisher
    ..and ischaemic cholangiopathy are the most feared complications following donation-after-circulatory-death (DCD) liver transplantation...
  69. Li J, Li B, Zhang Z, Wang S, Liu L. Ilizarov external fixation versus plate internal fixation in the treatment of end-stage ankle arthritis: decision analysis of clinical parameters. Sci Rep. 2017;7:16155 pubmed publisher
    ..The purpose of this study was to evaluate the effect of Ilizarov external fixation (IEF) and plate internal fixation (PIF) in the treatment of end-stage ankle arthritis on pain relieving and function improvement...
  70. Niu M, Wang Y, Wang C, Lyu J, Wang Y, Dong H, et al. ALR encoding dCMP deaminase is critical for DNA damage repair, cell cycle progression and plant development in rice. J Exp Bot. 2017;: pubmed publisher
    Deoxycytidine monophosphate deaminase (dCMP deaminase, DCD) is crucial to the production of dTTP needed for DNA replication and damage repair...
  71. Simonis Bik A, Nijpels G, van Haeften T, Houwing Duistermaat J, Boomsma D, Reiling E, et al. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. Diabetes. 2010;59:293-301 pubmed publisher
    ..All subjects were genotyped for gene variants in JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, THADA, ADAMTS9, NOTCH2/ADAMS30, DCD, VEGFA, BCL11A, HNF1B, WFS1, and MTNR1B...
  72. Blais M, Baly C, Biotteau M, Albaret J, Chaix Y, Tallet J. Lack of Motor Inhibition as a Marker of Learning Difficulties of Bimanual Coordination in Teenagers With Developmental Coordination Disorder. Dev Neuropsychol. 2017;42:207-219 pubmed publisher
    ..the learning of a new bimanual coordination in teenagers with and without Developmental Coordination Disorder (DCD). Both groups improved accuracy of the new coordination. No difference was found on stability...
  73. Xin R, Zhu L, Salome P, Mancini E, Marshall C, Harmon F, et al. SPF45-related splicing factor for phytochrome signaling promotes photomorphogenesis by regulating pre-mRNA splicing in Arabidopsis. Proc Natl Acad Sci U S A. 2017;114:E7018-E7027 pubmed publisher
    ..INTERACTING FACTORS (PIFs) transcription factor genes act downstream of SFPS, as the quadruple pif mutant pifq suppresses defects of sfps mutants...
  74. Luc J, Jackson K, Weinkauf J, Freed D, Nagendran J. Feasibility of Lung Transplantation From Donation After Circulatory Death Donors Following Portable Ex Vivo Lung Perfusion: A Pilot Study. Transplant Proc. 2017;49:1885-1892 pubmed publisher
    Donation after circulatory death (DCD) has the potential to significantly alleviate the shortage of transplantable lungs...
  75. Bonney E, Ferguson G, Smits Engelsman B. The efficacy of two activity-based interventions in adolescents with Developmental Coordination Disorder. Res Dev Disabil. 2017;71:223-236 pubmed publisher
    Adolescents with Developmental Coordination Disorder (DCD) usually experience psychomotor difficulties that affect their participation in everyday tasks and sports...
  76. Nakano T, Yoshino T, Fujimura T, Arai S, Mukuno A, Sato N, et al. Reduced expression of dermcidin, a peptide active against propionibacterium acnes, in sweat of patients with acne vulgaris. Acta Derm Venereol. 2015;95:783-6 pubmed publisher
    b>Dermcidin (DCD), an antimicrobial peptide with a broad spectrum of activity against bacteria such as Propionibacterum acnes, is expressed constitutively in sweat in the absence of stimulation due to injury or inflammation...
  77. Wang X, Liu X, Makalliwa G, Li J, Wang H, Hu Z, et al. Per os infectivity factors: a complicated and evolutionarily conserved entry machinery of baculovirus. Sci China Life Sci. 2017;60:806-815 pubmed publisher
    ..Interestingly, PIF homologs are also present in other invertebrate large DNA viruses, which is indicative that per os infection is an ..
  78. Kaths J, Paul A, Robinson L, Selzner M. Ex vivo machine perfusion for renal graft preservation. Transplant Rev (Orlando). 2018;32:1-9 pubmed publisher
    ..the donor pool are grafts recovered from extended criteria donors (ECD) and donation after circulatory death (DCD)...
  79. Xavier J, Magnat J, Sherman A, Gauthier S, Cohen D, Chaby L. A developmental and clinical perspective of rhythmic interpersonal coordination: From mimicry toward the interconnection of minds. J Physiol Paris. 2016;110:420-426 pubmed publisher
    ..Finally, to clinically illustrate our idea, we focus on developmental coordination disorder (DCD), a condition characterized not only by learning difficulties, but also childhood deficits in motor imitation...
  80. Wilmut K, Barnett A. When an object appears unexpectedly: foot placement during obstacle circumvention in children and adults with Developmental Coordination Disorder. Exp Brain Res. 2017;235:2947-2958 pubmed publisher
    ..Previous studies have demonstrated a difficulty in individuals with Developmental Coordination Disorder (DCD) in controlling stability while both stepping over and while circumventing an obstacle...
  81. Wonfor R, Natoli M, Rose M, Nash D. Effects of preimplantation factor on interleukin-6 and prostaglandin F2α and E2 in the bovine endometrium. Theriogenology. 2017;102:174-182 pubmed publisher
    Preimplantation factor (PIF) is a pregnancy specific peptide with immune modulatory properties exerted on the human endometrium...
  82. Strömberg N, Esberg A, Sheng N, Mårell L, Löfgren Burström A, Danielsson K, et al. Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2. EBioMedicine. 2017;26:38-46 pubmed publisher
    ..mutans. The high susceptibility P4a (Db, PIF, PRP12) children had more caries despite receiving extra prevention and irrespective of eating sugar or ..
  83. Heylen L, Pirenne J, Samuel U, Tieken I, Naesens M, Sprangers B, et al. The Impact of Anastomosis Time During Kidney Transplantation on Graft Loss: A Eurotransplant Cohort Study. Am J Transplant. 2017;17:724-732 pubmed publisher
    ..00, 95% CI 0.97-1.02). Kidneys from donation after circulatory death (DCD) were less tolerant of prolonged anastomosis time than kidneys from donation after brain death (p = 0...
  84. Xu Z, Liu J, Ni W, Peng Z, Guo Y, Ye W, et al. GrTEdb: the first web-based database of transposable elements in cotton (Gossypium raimondii). Database (Oxford). 2017;2017: pubmed publisher
    ..sequence similarity, including 2929 Copia-like elements, 10 368 Gypsy-like elements, 299 L1 , 12 Mutators , 435 PIF-Harbingers , 275 CACTAs and 14 Helitrons ...
  85. Schlegel A, Kalisvaart M, Muiesan P. Machine perfusion in liver transplantation: an essential treatment or just an expensive toy?. Minerva Anestesiol. 2018;84:236-245 pubmed publisher
    ..Second, we report on improvement strategies of marginal liver grafts by different machine perfusion concepts and summarize perfusion approaches with recent clinical implementation. ..
  86. Purcell C, Romijn A. Appropriateness of different pedagogical approaches to road safety education for children with Developmental Coordination Disorder (DCD). Res Dev Disabil. 2017;70:85-93 pubmed publisher
    ..Children with Developmental Coordination Disorder (DCD), a chronic disorder affecting the acquisition and execution of motor skills, may be more vulnerable at the ..
  87. He X, Ji F, Zhang Z, Tang Y, Yang L, Huang S, et al. Combined Liver-kidney Perfusion Enhances Protective Effects of Normothermic Perfusion on Livers Grafts from Donation after Cardiac Death. Liver Transpl. 2017;: pubmed publisher
    ..the combined perfusion is superior to liver perfusion alone in protecting livers from donation after cardiac death (DCD) is unclear. We aimed to test the hypothesis and explored the mechanisms...
  88. McGee A, Gardiner D, Murphy P. Determination of death in donation after circulatory death: an ethical propriety. Curr Opin Organ Transplant. 2017;: pubmed publisher
    The recently developed donation after circulatory death (DCD) heart transplant technique, pioneered by Papworth Hospital in the UK, involves the use of extracorporeal perfusion technologies to restart the donor heart in situ and thereby ..
  89. Bank S, Jana P, Maiti S, Guha S, Sinha A. Dermcidin isoform-2 induced nullification of the effect of acetyl salicylic acid in platelet aggregation in acute myocardial infarction. Sci Rep. 2014;4:5804 pubmed publisher
    ..The concentration of a stress induced protein (dermcidin isoform-2) was much higher in AMI than that in ACS...
  90. Gagnon Roy M, Jasmin E, Camden C. Social participation of teenagers and young adults with developmental co-ordination disorder and strategies that could help them: results from a scoping review. Child Care Health Dev. 2016;42:840-851 pubmed publisher
    The impact of developmental co-ordination disorder (DCD) on teenagers' and young adults' participation is not well documented...
  91. Taylor L, Buffington A, Scalea J, Fost N, Croes K, Mezrich J, et al. Harms of unsuccessful donation after circulatory death: An exploratory study. Am J Transplant. 2018;18:402-409 pubmed publisher
    While donation after circulatory death (DCD) has expanded options for organ donation, many who wish to donate are still unable to do so...
  92. Li C, Zhao Q, Zhang W, Chen M, Ju W, Wu L, et al. MicroRNA-146b-5p Identified in Porcine Liver Donation Model is Associated with Early Allograft Dysfunction in Human Liver Transplantation. Med Sci Monit. 2017;23:5876-5884 pubmed
    ..model of organ donation, including donation after brain death (DBD) group, donation after circulatory death (DCD) group, and DBCD group...