Gene Symbol: DAZ1
Description: deleted in azoospermia 1
Alias: DAZ, SPGY, deleted in azoospermia protein 1, testicular tissue protein Li 49
Species: human
Products:     DAZ1

Top Publications

  1. Reijo R, Lee T, Salo P, Alagappan R, Brown L, Rosenberg M, et al. Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat Genet. 1995;10:383-93 pubmed
    ..The region contains a single-copy gene, DAZ (Deleted in AZoospermia), which is transcribed in the adult testis and appears to encode an RNA binding protein...
  2. Saxena R, de Vries J, Repping S, Alagappan R, Skaletsky H, Brown L, et al. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. Genomics. 2000;67:256-67 pubmed
    The DAZ genes are candidate fertility factors that lie within the human Y chromosome's AZFc region, whose deletion is a common cause of spermatogenic failure...
  3. Xu E, Moore F, Pera R. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. Proc Natl Acad Sci U S A. 2001;98:7414-9 pubmed
    The Deleted in AZoospermia (DAZ) genes encode potential RNA-binding proteins that are expressed exclusively in prenatal and postnatal germ cells and are strong candidates for human fertility factors...
  4. Carty D, Miller Z, Thornton C, Pandelides Z, Kutchma M, Willett K. Multigenerational consequences of early-life cannabinoid exposure in zebrafish. Toxicol Appl Pharmacol. 2019;364:133-143 pubmed publisher
    ..The results highlight the need to consider long-term ramifications of early-life exposure to cannabinoids. ..
  5. Bansal S, Gupta N, Sankhwar S, Rajender S. Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis. PLoS ONE. 2015;10:e0127007 pubmed publisher
    ..heat shock proteins (DNAJB4, DNAJB14), testis specific genes (TCP11, TESK1, TSPYL1, ADAD1), and Y-chromosome genes (DAZ1, TSPYL1). A complex RNA population in spermatozoa consisted of coding and non-coding RNAs...
  6. Ghorbel M, Baklouti Gargouri S, Keskes R, Chakroun N, Sellami A, Fakhfakh F, et al. gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population. Gene. 2016;592:29-35 pubmed publisher
    ..the frequency of AZFc subdeletion in infertile and fertile men from Tunisia and to identify whether deletions of DAZ and CDY1 gene copies are deleterious on spermatogenesis and on semen quality...
  7. Heim A, Hartung O, Rothhämel S, Ferreira E, Jenny A, Marlow F. Oocyte polarity requires a Bucky ball-dependent feedback amplification loop. Development. 2014;141:842-54 pubmed publisher
  8. Mozdarani H, Ghoraeian P, Mozdarani S, Fallahi P, Mohseni Meybodi A. High frequency of de novo DAZ microdeletion in sperm nuclei of subfertile men: possible involvement of genome instability in idiopathic male infertility. Hum Fertil (Camb). 2018;21:137-145 pubmed publisher
    The occurrence and diagnosis of Y-chromosome microdeletions, specifically deletions of the DAZ (Deleted in Azoospermia) genes are an important issue in male infertility...
  9. Rosario R, Smith R, Adams I, Anderson R. RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary. Mol Hum Reprod. 2017;23:177-186 pubmed publisher
    ..This study was supported by the UK Medical Research Council (grant no G1100357 to R.A.A. and an intramural MRC programme grant to I.R.A.). The authors declare no competing interests. ..

More Information

Publications131 found, 100 shown here

  1. Ahmadivand S, Farahmand H, Teimoori Toolabi L, Mirvaghefi A, Eagderi S, Geerinckx T, et al. Boule gene expression underpins the meiotic arrest in spermatogenesis in male rainbow trout (Oncorhynchus mykiss) exposed to DEHP and butachlor. Gen Comp Endocrinol. 2016;225:235-241 pubmed publisher
    Boule, the ancestor of the DAZ (Deleted in AZoospermia) gene family, in most organisms is mainly involved in male meiosis...
  2. Malic S, Rai S, Redfern J, Pritchett J, Liauw C, Verran J, et al. Zeolite-embedded silver extends antimicrobial activity of dental acrylics. Colloids Surf B Biointerfaces. 2019;173:52-57 pubmed publisher
    ..Here, we report the post-synthesis introduction of silver in zeolite-loaded dental acrylic (DAZ) resins that does not influence the mechanical or aesthetic properties of the DA resins, and provides them with a ..
  3. Chen F, Demers L, Vallyathan V, Lu Y, Castranova V, Shi X. Impairment of NF-kappaB activation and modulation of gene expression by calpastatin. Am J Physiol Cell Physiol. 2000;279:C709-16 pubmed
    ..genes encoding several membrane-associated proteins or nuclear proteins and upregulated genes of collagen alpha2, DAZ, and mitochondrial capsule selenoprotein...
  4. Spice E, Whyard S, Docker M. Gene expression during ovarian differentiation in parasitic and non-parasitic lampreys: implications for fecundity and life history types. Gen Comp Endocrinol. 2014;208:116-25 pubmed publisher
    ..dehydrogenase, germ cell-less, estrogen receptor β, insulin-like growth factor 1 receptor, daz-associated protein 1, cytochrome c oxidase subunit III, Wilms' tumour suppressor protein 1, and dehydrocholesterol ..
  5. Shah S, Saini N, Ashraf S, Singh M, Manik R, Singla S, et al. Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells. Reprod Fertil Dev. 2017;29:679-693 pubmed publisher
    ..Oocyte-like structures obtained in monolayer differentiation stained positive for ZONA PELLUCIDA protein 4 and progressed through various embryo-like developmental stages in extended cultures. ..
  6. Vaszkó T, Papp J, Krausz C, Casamonti E, Geczi L, Olah E. Discrimination of Deletion and Duplication Subtypes of the Deleted in Azoospermia Gene Family in the Context of Frequent Interloci Gene Conversion. PLoS ONE. 2016;11:e0163936 pubmed publisher
    ..Besides DAZ1/DAZ2 and DAZ3/DAZ4 deletions, not yet described rearrangements such as DAZ2/DAZ4 deletion and three duplication ..
  7. Qiu C, Ma S, Chen Y, Meng Z, Wang J. Reliable Acoustic Path and Direct-Arrival Zone Spatial Gain Analysis for a Vertical Line Array. Sensors (Basel). 2018;18: pubmed publisher
    ..array locations are simulated and analyzed based on the sound propagation properties of the direct-arrival zone (DAZ) and the reliable acoustic path (RAP) using ray theory...
  8. Zhu Y, Ma M, Wan L, Zhang D, Zhao L, Wei L, et al. Analysis of DAZL SNP260 and SNP386 in infertile Chinese males using multi-analyte suspension array. Mol Med Rep. 2014;10:2949-54 pubmed publisher
    ..The method was applied to detect SNP polymorphisms in the DAZL gene; and neither the A260G nor the A386G polymorphism of DAZL appeared to be involved in male infertility in the Chinese population. ..
  9. Stefanidis K, Pergialiotis V, Christakis D, Patta J, Stefanidi D, Loutradis D. OCT-4 and DAZL expression in precancerous lesions of the human uterine cervix. J Obstet Gynaecol Res. 2015;41:763-7 pubmed publisher
    ..066). The relative expression of OCT-4 is upregulated during the early, preinvasive stages of cervical carcinogenesis. Future studies should investigate its potential as a screening marker and as a possible target of therapy. ..
  10. Sekiné K, Furusawa T, Hatakeyama M. The boule gene is essential for spermatogenesis of haploid insect male. Dev Biol. 2015;399:154-163 pubmed publisher
    boule (bol), a member of the Deleted in Azoospermia (DAZ) gene family plays an important role in meiosis (reductional maturation divisions) in a spermatogenesis-specific manner in animals by regulating translation of the downstream cell ..
  11. Gonzalez C, Dorfman V, Vitullo A. IGF1 regulation of BOULE and CDC25A transcripts via a testosterone-independent pathway in spermatogenesis of adult mice. Reprod Biol. 2015;15:48-55 pubmed publisher
    The Deleted in AZoospermia (DAZ) gene family plays an essential role in spermatogenesis and fertility in mammals. This gene family contains two autosomal genes, BOULE and DAZL (DAZ-Like), and the DAZ gene cluster in the Y chromosome...
  12. Kumari A, Yadav S, Misro M, Ahmad J, Ali S. Copy number variation and microdeletions of the Y chromosome linked genes and loci across different categories of Indian infertile males. Sci Rep. 2015;5:17780 pubmed publisher
    ..Significantly, SRY, DAZ and BPY2 genes showed copy number variation across different categories of the patients and much reduced copies of ..
  13. Krausz C, Giachini C, Xue Y, O Bryan M, Gromoll J, Rajpert De Meyts E, et al. Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background. J Med Genet. 2009;46:21-31 pubmed publisher
    ..In total, 169 men diagnosed with gr/gr deletions from six centres in Europe and one in Australia were studied. The DAZ and CDY1 copies retained, the presence or absence of duplications and the Y-chromosomal haplogroup were ..
  14. Wang Y, Ye J, Li Z, Zheng S, Ma L, Guo H, et al. [Identification of null and duplicated alleles for forensic DYS549, DYS527 and DYS459 in male infertility population]. Yi Chuan. 2014;36:786-92 pubmed publisher
    ..In this study, we determined the AZF polymorphism by STS(-/-) (sequence tagged site) and DAZ, CDY1 gene copy numbers, and screened the samples by 14 Y-STR loci to disclose the unusual genotype of Y-STR in ..
  15. Lai D, Xu M, Zhang Q, Chen Y, Li T, Wang Q, et al. Identification and characterization of epithelial cells derived from human ovarian follicular fluid. Stem Cell Res Ther. 2015;6:13 pubmed publisher
    ..The epithelial cells derived from follicular fluid are a potential stem cell source with a pluripotent/multipotent character for safe application in oogenesis and regenerative medicine. ..
  16. Levi M, Popovtzer A, Tzabari M, Mizrachi A, Savion N, Stemmer S, et al. Cetuximab intensifies cisplatin-induced testicular toxicity. Reprod Biomed Online. 2016;33:102-10 pubmed publisher
    ..In conclusion, cetuximab has only a mild effect on testicular reserve, but when added to cisplatin, it exacerbates cisplatin-induced testicular toxicity. ..
  17. Pramod R, Lee B, Kim Y, Lee H, Park Y, Ono T, et al. Isolation, Characterization, and In Vitro Culturing of Spermatogonial Stem Cells in Japanese Quail (Coturnix japonica). Stem Cells Dev. 2017;26:60-70 pubmed publisher
    ..Quail SSCs will facilitate the production of germline chimeras and transgenesis. ..
  18. Wu F, Zhou W, Han Y, Fu X, Xu Y, Hou H. Effect of Alloying Elements Gradient on Solid-State Diffusion Bonding between Aerospace Aluminum Alloys. Materials (Basel). 2018;11: pubmed publisher
    ..A diffusion affected zone (DAZ) without continuous intermetallic phases formed due to the diffusion of alloying elements across the bonding ..
  19. Duggal G, Heindryckx B, Warrier S, Taelman J, Van der Jeught M, Deforce D, et al. Exogenous supplementation of Activin A enhances germ cell differentiation of human embryonic stem cells. Mol Hum Reprod. 2015;21:410-23 pubmed publisher
    ..We propose a novel relationship between the endoderm and germ cell lineage during hESC differentiation. ..
  20. Li M, Zhu F, Li Z, Hong N, Hong Y. Dazl is a critical player for primordial germ cell formation in medaka. Sci Rep. 2016;6:28317 pubmed publisher
    The DAZ family genes boule, daz and dazl have conserved functions in primordial germ cell (PGC) migration, germ stem cell proliferation, differentiation and meiosis progression...
  21. Chen P, Wang X, Xu C, Xiao H, Zhang W, Wang X, et al. Association of polymorphisms of A260G and A386G in DAZL gene with male infertility: a meta-analysis and systemic review. Asian J Androl. 2016;18:96-101 pubmed publisher
    ..However, this correlation was only found in China with a country-specific and ethnicity-specific manner. ..
  22. Sousa Martins J, Liu X, Oke A, Arora R, Franciosi F, Viville S, et al. DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. J Cell Sci. 2016;129:1271-82 pubmed publisher
    ..Mechanistically, the number of DAZL proteins loaded onto the mRNA and the characteristics of the CPE might define the degree of cooperation between the two RBPs in activating translation and meiotic progression. ..
  23. Nailwal M, Chauhan J. In silico analysis of non-synonymous single nucleotide polymorphisms in human DAZL gene associated with male infertility. Syst Biol Reprod Med. 2017;63:248-258 pubmed publisher
  24. Leng L, Tan Y, Gong F, Hu L, Ouyang Q, Zhao Y, et al. Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency. Hum Reprod. 2015;30:737-48 pubmed publisher
    ..81222007 and 81471432), the Program for New Century Excellent Talents in University and the Fundamental Research Funds for Central Universities (No. 721500003). The authors have no competing interests to declare. Not applicable. ..
  25. Kang K, Pyo J, Ryu K, Kim S, Ha J, Choi K, et al. Oncogenic Role of BOLL in Colorectal Cancer. Dig Dis Sci. 2015;60:1663-73 pubmed publisher
    Boule-like RNA-binding protein (BOLL protein) is the progenitor of the Deleted in Azoospermia (DAZ) gene family. To date, previous studies have focused on the reproductive function of BOLL...
  26. Kleiman S, Yogev L, Lehavi O, Yavetz H, Hauser R. Distinctive pattern of expression of spermatogenic molecular markers in testes of azoospermic men with non-mosaic Klinefelter syndrome. J Assist Reprod Genet. 2016;33:807-14 pubmed publisher
    ..tubules with cells and abnormal thickness of the basement membrane) and expression of spermatogenetic markers (DAZ, RBM, BOLL, and CDY1) were evaluated and compared among those subgroups...
  27. Jung H, Song H, Yoon M. The KIT is a putative marker for differentiating spermatogonia in stallions. Anim Reprod Sci. 2015;152:39-46 pubmed publisher
    ..In conclusion, KIT appears to be expressed in differentiating spermatogonia, and may be used to identify and isolate differentiating germ cells from stallions. ..
  28. Purcell D, Chauhan S, Jimenez Stinson D, Elliott K, Tsewang T, Lee Y, et al. Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-α. Mol Endocrinol. 2015;29:1708-19 pubmed publisher
    ..Here, we have identified an E3 ubiquitin ligase, DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3), as a novel CARM1-binding protein...
  29. Li B, Ngo S, Wu W, Xu H, Xie Z, Li Q, et al. Identification and characterization of yak (Bos grunniens) b-Boule gene and its alternative splice variants. Gene. 2014;550:193-9 pubmed publisher
    ..888bp and encodes a 295-amino acid protein with a typical RNA-recognition motif (RRM) and a Deleted in Azoospermia (DAZ) repetitive sequence motif...
  30. He T, Zhang X, Deng H, Zhou W, Zhao X, Zhao H, et al. A novel Y chromosome microdeletion potentially associated with defective spermatogenesis identified by custom array comparative genome hybridization. Reprod Biomed Online. 2017;34:75-81 pubmed publisher
    ..Our study indicated that this newly identified Y chromosome deletion might be potentially associated with impaired spermatogenesis and it is worthy of further investigations in larger cohorts. ..
  31. Luan N, Sharma N, Kim S, Ha P, Hong Y, Oh S, et al. Characterization and cardiac differentiation of chicken spermatogonial stem cells. Anim Reprod Sci. 2014;151:244-55 pubmed publisher
  32. Hu X, Lu H, Cao S, Deng Y, Li Q, Wan Q, et al. Stem cells derived from human first-trimester umbilical cord have the potential to differentiate into oocyte-like cells in vitro. Int J Mol Med. 2015;35:1219-29 pubmed publisher
    ..Thus, our findings suggest that hFTUC-derived stem cells have an intrinsic ability to differentiate into OLCs, which may provide an in vitro model for the identification of factors involved in germ cell formation and differentiation. ..
  33. Otori M, Karashima T, Yamamoto M. The Caenorhabditis elegans homologue of deleted in azoospermia is involved in the sperm/oocyte switch. Mol Biol Cell. 2006;17:3147-55 pubmed
    The Deleted in Azoospermia (DAZ) gene family encodes putative translational activators that are required for meiosis and other aspects of gametogenesis in animals...
  34. Vogt P, Fernandes S. Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?. APMIS. 2003;111:115-26; discussion 126-7 pubmed
    ..23 euchromatin? We discuss also the polymorphic DAZ gene family and disclose putative origins of its molecular heterogeneity in fertile and infertile men recently ..
  35. Shafae M, Sabry J, Behiry E, Sabry H, Salim M, Fayez A. Independent of DAZL-T54A variant and AZF microdeletion in a sample of Egyptian patients with idiopathic non-obstructed azoospermia. Appl Clin Genet. 2018;11:81-87 pubmed publisher
    ..The present study observed that 15.6% had AZFc microdeletion, out of which 10% had DAZ1/2 deletion, and no T54A variant in the DAZL gene was found...
  36. Yang Y, Xiao C, A Z, Zhang S, Li X, Zhang S. DAZ1/DAZ2 cluster deletion mediated by gr/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men. Asian J Androl. 2006;8:183-7 pubmed
    ..Five (1.4%) of the normozoospermic men were found to have deletion of gr/gr-DAZ1/DAZ2. None of the men were found to have b2/b4-entire DAZ deletion...
  37. Zhang C, Wu J. Production of offspring from a germline stem cell line derived from prepubertal ovaries of germline reporter mice. Mol Hum Reprod. 2016;22:457-64 pubmed publisher
    ..none. This work was supported by National Basic Research Program of China (2013CB967401) and the National Nature Science Foundation of China (81370675, 81200472 and 81421061). The authors declare no competing interests. ..
  38. Smith R, Anderson R, Larralde O, Smith J, Gorgoni B, Richardson W, et al. Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding. Proc Natl Acad Sci U S A. 2017;114:6310-6315 pubmed publisher
    ..g., viral infection, cell stress). This mechanism adds significant insight into our knowledge of mRNA-specific translational activation and the function of the PABP-eIF4G complex in translation initiation. ..
  39. Ruggiu M, Cooke H. In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein. Gene. 2000;252:119-26 pubmed
    ..Two Y-encoded candidate spermatogenesis genes, RBMY and DAZ, have been isolated by positional cloning from infertile patients...
  40. Gianotten J, Hoffer M, de Vries J, Leschot N, Gerris J, van der Veen F. Partial DAZ deletions in a family with five infertile brothers. Fertil Steril. 2003;79 Suppl 3:1652-5 pubmed
    ..sequence family variant analysis was performed in leukocyte DNA to determine the number of deleted in azoospermia (DAZ) genes...
  41. Oikawa D, Shiota M, Tokunaga F, Wanibuchi H. Generation of Rat Monoclonal Antibodies Specific for DZIP3. Monoclon Antib Immunodiagn Immunother. 2018;37:153-157 pubmed publisher
    b>DAZ interacting zinc finger 3 (DZIP3), an RNA-binding RING-type ubiquitin ligase, has been reported to be involved in multiple physiological functions, including the regulation of chemokine- or estradiol-induced gene expression, self-..
  42. Guo K, Li C, Wang X, He D, Zheng P. Germ stem cells are active in postnatal mouse ovary under physiological conditions. Mol Hum Reprod. 2016;22:316-28 pubmed publisher
    ..Not applicable. This work was supported by the National Key Basic Research Program of China (grant number 2012CBA01300) and the National Natural Science Foundation of China to P.Z. (31571484). No competing interests are reported. ..
  43. Kee K, Angeles V, Flores M, Nguyen H, Reijo Pera R. Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. Nature. 2009;462:222-5 pubmed publisher
    ..human DAZL (deleted in azoospermia-like) functions in primordial germ-cell formation, whereas closely related genes DAZ and BOULE (also called BOLL) promote later stages of meiosis and development of haploid gametes...
  44. Kobayashi M, Tani Matsuhana S, Ohkawa Y, Sakamoto H, Inoue K. DND protein functions as a translation repressor during zebrafish embryogenesis. Biochem Biophys Res Commun. 2017;484:235-240 pubmed publisher
    ..Moreover, our data suggested that DND represses translation of nanog and dnd mRNAs, whereas an RNA-binding protein DAZ-like (DAZL) promotes dnd mRNA translation...
  45. Pathak D, Yadav S, Rawal L, Ali S. Mutational landscape of the human Y chromosome-linked genes and loci in patients with hypogonadism. J Genet. 2015;94:677-87 pubmed
    ..FISH uncovered mosaicism for SRY, AMELY,DAZ genes and DYZ1 arrays, structural rearrangement for AMELY (31%) and duplication of DAZ (57%) genes...
  46. Zhao G, Gong A, Wang Y, Zhang X, Li M, Mathy N, et al. Nuclear delivery of parasite Cdg2_FLc_0220 RNA transcript to epithelial cells during Cryptosporidium parvum infection modulates host gene transcription. Vet Parasitol. 2018;251:27-33 pubmed publisher
    ..Trans-suppression of the DAZ interacting zinc finger protein 1 like (DZIP1L) gene, the top overlapping downregulated gene in host cells ..
  47. Cheng T, Zhai K, Chang Y, Yao G, He J, Wang F, et al. CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells. Oncotarget. 2017;8:7814-7826 pubmed publisher
    ..Taken together, our results indicate that CHIR99021 combined with retinoic acid can effectively differentiate hESCs into PGCs via activating Wnt signaling pathway. ..
  48. Kim B, Rhee K. BOULE, a Deleted in Azoospermia Homolog, Is Recruited to Stress Granules in the Mouse Male Germ Cells. PLoS ONE. 2016;11:e0163015 pubmed publisher
    ..DAZL, one of DAZ (Deleted in Azoospermia) family proteins, was shown to be an essential component of SGs, which is required for SG ..
  49. Szczerba A, Jankowska A, Andrusiewicz M, Warchoł J. Localization of the DAZ gene expression in seminiferous tubules of patients with spermatogenic disorders. Folia Histochem Cytobiol. 2006;44:123-6 pubmed
    The research on the expression and mutations of DAZ and its homologues in human and other mammals suggests that protein products of these genes can mainly affect development of germinal cells...
  50. Lee H, Choi H, Lee H, Lim J, Ono T, Han J. DAZL Expression Explains Origin and Central Formation of Primordial Germ Cells in Chickens. Stem Cells Dev. 2016;25:68-79 pubmed publisher
    ..In conclusion, DAZL expression reveals formation and initial positioning of PGCs in chickens. ..
  51. Iyer H, Issigonis M, Sharma P, Extavour C, Newmark P. A premeiotic function for boule in the planarian Schmidtea mediterranea. Proc Natl Acad Sci U S A. 2016;113:E3509-18 pubmed publisher
    Mutations in Deleted in Azoospermia (DAZ), a Y chromosome gene, are an important cause of human male infertility...
  52. Khanlarkhani N, Pasbakhsh P, Mortezaee K, Naji M, Amidi F, Najafi A, et al. Effect of human recombinant granulocyte colony-stimulating factor on rat busulfan-induced testis injury. J Mol Histol. 2016;47:59-67 pubmed publisher
    ..05). Our results revealed that G-CSF application prior to busulfan insult is a promising approach in fertility maintenance. ..
  53. Wu W, Lu C, Xia Y, Shen O, Ji G, Gu A, et al. Lack of association between DAZ gene methylation patterns and spermatogenic failure. Clin Chem Lab Med. 2010;48:355-60 pubmed publisher
    ..To investigate the association between DAZ gene methylation patterns and spermatogenic failure, we performed an analysis of methylation patterns in 174 ..
  54. Lee W, Lee R, Park H, Do J, Park C, Kim J, et al. Characterization of male germ cell markers in canine testis. Anim Reprod Sci. 2017;182:1-8 pubmed publisher
    ..This study might facilitate the identification of stage-specific canine germ cell markers and cellular mechanisms of spermatogenesis. ..
  55. Yao W, Li Y, Li B, Luo H, Xu H, Pan Z, et al. Epigenetic regulation of bovine spermatogenic cell-specific gene boule. PLoS ONE. 2015;10:e0128250 pubmed publisher
    Non-primate mammals have two deleted azoospermia (DAZ) family genes, DAZL and Boule; genes in this family encode RNA-binding proteins essential for male fertility in diverse animals...
  56. Lu H, Galeano M, Ott E, Kaeslin G, Kausalya P, Kramer C, et al. Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nat Genet. 2017;49:1025-1034 pubmed publisher
    ..Here, we describe mutations in DZIP1L, which encodes DAZ interacting protein 1-like, in patients with ARPKD...
  57. Rosario R, Adams I, Anderson R. Is there a role for DAZL in human female fertility?. Mol Hum Reprod. 2016;22:377-83 pubmed publisher
    ..Here, we suggest that DAZL may be one such factor, and there is a need for greater understanding of the role of DAZL in human oogenesis and its contribution to lifelong female fertility. ..
  58. Pieri N, Souza A, Mançanares A, Roballo K, Casals J, Ambrosio C, et al. Immunolocalization of proteins in the spermatogenesis process of canine. Reprod Domest Anim. 2017;52 Suppl 2:170-176 pubmed publisher
    ..Our results demonstrate that these proteins play critical roles in the self-renewal and differentiation of SSCs and can serve as markers to identify canine spermatogonia at specific stages of development. ..
  59. Zhao S, Chen X, Deng S, Dong X, Song A, Yao J, et al. The Effects of Fungicide, Soil Fumigant, Bio-Organic Fertilizer and Their Combined Application on Chrysanthemum Fusarium Wilt Controlling, Soil Enzyme Activities and Microbial Properties. Molecules. 2016;21:526 pubmed publisher
    ..The treatments comprised the fungicide carbendazim (MBC), the soil fumigant dazomet (DAZ), the incorporation of a Paenibacillus polymyxa SQR21 (P...
  60. Morton S, Yang H, Moleleki N, Campbell D, Cohen P, Rousseau S. Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ. Biochem J. 2006;399:265-73 pubmed
    ..phosphorylated in response to LPS (lipopolysaccharide), was identified as the RNA-binding protein called DAZAP1 [DAZ (deleted in azoospermia)-associated protein 1]...
  61. Stewart J, Piligian B, Rundell S, Swarts B. A trifunctional cyclooctyne for modifying azide-labeled biomolecules with photocrosslinking and affinity tags. Chem Commun (Camb). 2015;51:17600-3 pubmed publisher
    A bicyclo[6.1.0]nonyne (BCN)-based cyclooctyne reagent bearing a photocrosslinking diazirine (DAz) group and a biotin affinity handle, BCN-DAz-Biotin, is reported...
  62. Lepretre A, Patrat C, Mitchell M, Jouannet P, Bienvenu T. No partial DAZ deletions but frequent gene conversion events on the Y chromosome of fertile men. J Assist Reprod Genet. 2005;22:141-8 pubmed
    Recently, partial DAZ deletions on the Y chromosome were identified in infertile men. To determine the clinical importance of partial DAZ deletion, we studied the number of DAZ copies in a well-defined population of 47 fertile men...
  63. Yang Y, Xiao C, Zhang S, Cheng H, Zhang S, Huang M, et al. [Important genetic etiology of infertile Chinese males: chromosome abnormality and deletion of DAZ gene copy in the AZFc region of Y chromosome]. Zhonghua Nan Ke Xue. 2005;11:494-8 pubmed
    ..6% and 8.3%; the rates of complete DAZ deletion were 7.7% and 11.2%, and the rates of DAZ1/DAZ2 deletion were 7.3% and 4.9% respectively, but no deletion was detected in the controls...
  64. Oetjens M, Shen F, Emery S, Zou Z, Kidd J. Y-Chromosome Structural Diversity in the Bonobo and Chimpanzee Lineages. Genome Biol Evol. 2016;8:2231-40 pubmed publisher
    ..and identify several lineage-specific patterns, including variable copy number of azoospermia candidates RBMY and DAZ We detect recurrent switchpoints of copy-number change along the ampliconic tracts across chimpanzee populations, ..
  65. Ferlin A, Moro E, Rossi A, Foresta C. A novel approach for the analysis of DAZ gene copy number in severely idiopathic infertile men. J Endocrinol Invest. 2002;25:RC1-3 pubmed
    The deleted-in-azoospermia (DAZ) gene family constitutes the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility, being deleted in about 10% of azoospermic and severely oligozoospermic subjects...
  66. Yang Y, Xiao C, Zhang S, Lin L, Wei W. [Idiopathic male infertility and partial copy deletion of DAZ gene family]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004;21:444-7 pubmed
    ..Deletion of both DAZ1 and DAZ2 was detected in 18 patients with azoospermia and 10 with severe oligozoospermia, and the prevalence was 9...
  67. Collier B, Gorgoni B, Loveridge C, Cooke H, Gray N. The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells. EMBO J. 2005;24:2656-66 pubmed
    ..Here we demonstrate that members of this family, including Xdazl, mouse Dazl, human DAZL, human DAZ and human BOULE, have the ability to stimulate translation and function at the level of translation initiation...
  68. Lin Y, Thi D, Kuo P, Hsu C, Huang B, Yu Y, et al. Polymorphisms associated with the DAZ genes on the human Y chromosome. Genomics. 2005;86:431-8 pubmed
    ..with increased risk for spermatogenic failure, the gr/gr deletion, removes two of the four Deleted in Azoospermia (DAZ) genes in the AZFc region on the Y-chromosome long arm...
  69. Lardone M, Parodi D, Valdevenito R, Ebensperger M, Piottante A, Madariaga M, et al. Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis. Mol Hum Reprod. 2007;13:705-12 pubmed
    ..This study investigated the expression level of AZF genes, DDX3Y (DBY), RBMY1, DAZ and TSPY in testicular tissues of 42 subjects with impaired spermatogenesis compared with 33 with normal ..
  70. Kim B, Lee W, Rhee K, Kim S, Paick J. Analysis of DAZ gene expression in a partial AZFc deletion of the human Y chromosome. Reprod Fertil Dev. 2014;26:307-15 pubmed publisher
    ..site polymerase chain reaction (PCR) and is generally believed to retain two of the four deleted in azoospermia (DAZ) genes on the Y chromosome...
  71. Li Q, Qiao D, Song N, Ding Y, Wang Z, Yang J, et al. Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. World J Urol. 2013;31:1403-9 pubmed publisher
    ..DAZ-SNV loci analysis revealed 4 DAZ copies that had 8 gr/gr-DAZ3/DAZ4 deletions and 1 gr/gr-DAZ1/DAZ2 deletion in the fertile men (8/190 vs. 1/190, p = 0.037)...
  72. Lu C, Wang Y, Zhang F, Lu F, Xu M, Qin Y, et al. DAZ duplications confer the predisposition of Y chromosome haplogroup K* to non-obstructive azoospermia in Han Chinese populations. Hum Reprod. 2013;28:2440-9 pubmed publisher
    ..of certain Y chromosome haplogroups (Y-hgs) to spermatogenic impairment? The AZFc(azoospermia factor c)/DAZ (deleted in azoospermia) duplications might underlie the susceptibility of Y-hg K* to spermatogenic impairment...
  73. Cooke H, Lee M, Kerr S, Ruggiu M. A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads. Hum Mol Genet. 1996;5:513-6 pubmed
    We have isolated a homologue of the human Y linked DAZ (deleted in azoospermia) gene from mouse. This gene, Dazla (Daz like, autosomal), is autosomal, located on chromosome 17 and apparently single copy...
  74. Saxena R, Brown L, Hawkins T, Alagappan R, Skaletsky H, Reeve M, et al. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. Nat Genet. 1996;14:292-9 pubmed
    It is widely believed that most or all Y-chromosomal genes were once shared with the X chromosome. The DAZ gene is a candidate for the human Y-chromosomal Azoospermia Factor (AZF)...
  75. Yen P, Chai N, Salido E. The human autosomal gene DAZLA: testis specificity and a candidate for male infertility. Hum Mol Genet. 1996;5:2013-7 pubmed
    The DAZ (Deleted in AZoospermia) and DAZLA (DAZ-like autosomal) genes may be determinants of male infertility. The DAZ gene on the long arm of the human Y chromosome is a strong candidate for the 'azoospermia factor' (AZF)...
  76. Tsui S, Dai T, Roettger S, Schempp W, Salido E, Yen P. Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1. Genomics. 2000;65:266-73 pubmed
    The human DAZ (deleted in azoospermia) gene family on the Y chromosome and an autosomal DAZ-like gene, DAZL1, encode RNA-binding proteins that are expressed exclusively in germ cells...
  77. Foresta C, Ferlin A, Moro E, Marin P, Rossi A, Scandellari C. [Microdeletion of chromosome Y in male infertility: role of the DAZ gene]. Ann Ital Med Int. 2001;16:82-92 pubmed
    ..Mutations more frequently involve the DAZ gene in AZFc, and could determine both azoospermia and severe oligozoospermia...
  78. Ferlin A, Bettella A, Tessari A, Salata E, Dallapiccola B, Foresta C. Analysis of the DAZ gene family in cryptorchidism and idiopathic male infertility. Fertil Steril. 2004;81:1013-8 pubmed
    To investigate whether partial deletions of the DAZ gene family on the Y chromosome are associated with cryptorchidism, similar to that found for complete AZF deletions. Prospective study. University hospital...
  79. Sin H, Koh E, Shigehara K, Sugimoto K, Maeda Y, Yoshida A, et al. Features of constitutive gr/gr deletion in a Japanese population. Hum Reprod. 2010;25:2396-403 pubmed publisher
    ..The gr/gr deletion subtypes were not distributed randomly among haplogroups; the CDY1a+ DAZ1/2 genes were deleted in 96...
  80. Sen S, Ambulkar P, Hinduja I, Zaveri K, Gokral J, Pal A, et al. Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions. J Assist Reprod Genet. 2015;32:1333-41 pubmed publisher
    ..of this study was to determine the association of AZFc subdeletions (gr/gr, b1/b3 and b2/b3) and deletion of DAZ and CDY1 gene copies with male infertility Three hundred twelve controls, 172 azoospermic and 343 oligozoospermic ..
  81. Ahmadi Rastegar D, Sharifi Tabar M, Alikhani M, Parsamatin P, Sahraneshin Samani F, Sabbaghian M, et al. Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients. J Proteome Res. 2015;14:3595-605 pubmed publisher
    ..and AZFc region genes (USP9Y, DDX3Y, XKRY, HSFY1, CYORF15A, CYORF15B, KDM5D, EIF1AY, RPS4Y2, RBMY1A1, PRY, BPY2, DAZ1, and CDY1) as well as their X chromosome homologue transcripts and a few autosomal homologues...
  82. Menke D, Mutter G, Page D. Expression of DAZ, an azoospermia factor candidate, in human spermatogonia. Am J Hum Genet. 1997;60:237-41 pubmed
  83. Friel A, Houghton J, Glennon M, Lavery R, Smith T, Nolan A, et al. A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men. Int J Androl. 2002;25:59-64 pubmed
    In this study, reverse transcription-polymerase chain reaction (RT-PCR) was optimized to analyse the presence of DAZ, RBMY1, USP9Y, protamine-2, SRY and actin messenger RNA (mRNA) in testicular cells of men suffering from idiopathic ..
  84. Moore F, Jaruzelska J, Dorfman D, Reijo Pera R. Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. Genomics. 2004;83:834-43 pubmed
    Evidence from diverse organisms, including humans, suggests that the DAZ (Deleted in Azoospermia) gene and a closely related homolog, DAZL (DAZ-like), are required early in germ cell development to maintain initial germ cell populations...
  85. Lee K, Lee S, Kim B, Chang S, Kim S, Paick J, et al. Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs. EMBO J. 2006;25:4263-70 pubmed
    ..Genetic evidence has indicated that the DAZ family genes are critical for successful male germ cell development in diverse animals as well as humans...
  86. Alimardanian L, Saliminejad K, Razi S, Ahani A. Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia. Andrologia. 2016;48:890-894 pubmed publisher
    ..We investigated partial deletion of AZFc region and DAZ copy number in a population of Iranian infertile men and normozoospermic controls...
  87. Agulnik A, Zharkikh A, Boettger Tong H, Bourgeron T, McElreavey K, Bishop C. Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations. Hum Mol Genet. 1998;7:1371-7 pubmed
    ..Two different Y-located DAZ sequences were observed in all Old World monkeys, apes and humans...
  88. Foresta C, Bettella A, Moro E, Rossato M, Merico M, Garolla A, et al. Inhibin B plasma concentrations in infertile patients with DAZ gene deletions treated with FSH. Eur J Endocrinol. 2002;146:801-6 pubmed
    The DAZ (deleted in azoospermia) gene family on the Y chromosome long arm is the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility and it is expressed only in germ cells...
  89. Moore F, Jaruzelska J, Fox M, Urano J, Firpo M, Turek P, et al. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. Proc Natl Acad Sci U S A. 2003;100:538-43 pubmed
    ..Men with deletions encompassing the Y-chromosome DAZ genes have few or no germ cells but are otherwise healthy, indicating they harbor specific defects in formation or ..
  90. Kuo P, Wang S, Lin Y, Lin Y, Teng Y, Hsu C. Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure. Fertil Steril. 2004;81:1034-40 pubmed
    To determine the expression profiles of the DAZ gene family in men with and without spermatogenic failure. Prospective case study. University-based reproductive clinics and genetics laboratory...
  91. Writzl K, Sehić A, Terzić R, Peterlin B. Copy number of DAZ genes in Slovenian and Bosnian general population. Coll Antropol. 2004;28 Suppl 2:283-9 pubmed
    Deletions of two of four DAZ (Deleted in AZoospermia) gene copies located on the Y chromosome were associated with spermatogenic failure, but the information on DAZ copy number is still very scarce...